Name:___________________________________________________
Sliding Filament Theory -
The sliding filament theory explains muscle contraction based
on how muscle fibers (actin and myosin) slide against each other to generate tension in the overall muscle.
Step 1: A muscle contraction starts in the brain, where a signal is sent to the motor neuron (a). The
combination of the motor neuron and the skeletal muscle fibers make up a motor unit.
Color the motor neuron (a) yellow .
Vesicles that contain the neurotransmitter, acetylcholine. Color vesicles (b) gray
Color the triangles that represent the acetylcholine (c) orange .
Acetylcholine reaches the receptors (d) Color the receptors brown .
The gap between the neuron and muscle fiber is the synapse (e). Color this area light green .
The impulse travels down membrane, or sarcolemma. Color the sarcolemma (f) dark green .
Step 2: The impulse travels moves into the transverse tubules where it causes calcium to be released
from the sarcoplasmic reticulum.
Color the transverse tubule (g) light blue and the circles that represent calcium(h) dark blue .
The sarcoplasmic reticulum (i) is only partially pictured, color this structure pink .
Step 3: Calcium binds to the actin and causes it to change shape so that it can interact with myosin.
Color the actin myofilament (j) red.
Step 4: The change in shape allows myosin heads to form cross-bridges between the actin and myosin.
Color the myosin filament (m) yellow.
Color the cross bridges and their heads (k) purple.
Step 5: Energy from ATP is used to create a "power stroke" between the two filaments. The actin filament
slides inward and shortens, or contracts, the whole muscle.
Color the ATP orange. .
Questions:
1. The motor unit consists of muscle fibers and a _____________________________
2. What neurotransmitter is needed to initiate a muscle contraction? _________________________
3. What substance causes the actin to change shape? _______________________________
4.
5.
7.
8.
How does myosin and actin interact with each other? _________________________________
What substance provides the energy for muscle contraction? ___________________________
Where is calcium released from? ______________________________________________
What is the gap between the neuron and muscle fiber called? ___________________________
9. What are the two filaments found in muscles? _________________________________________
10. Place the steps in order:
___ Cross bridges form
___ Signal travels down the motor neuron
___ Calcium released from sarcoplasm
___ ATP creates a power stroke, shortening actin filament
___ Actin changes shape
www.biologycorner.com
www.biologycorner.com
www.biologycorner.com
www.biologycorner.com