Uploaded by ghyh20


Charleston, South Carolina
Charlotte, North Carolina
Better Life Carolinas
Age Management Wellness Center
Clinical Cases Using Exosomes
Case #1
● M.B. is a 58 year old, healthy, white male with history of hypertension and
erectile dysfunction
● Initial erectile hardness 1 out of 4. Shim score of 6
● Shockwave therapy 3 treatments given followed by P-shot with 1ml mixed
with 5 ml of Exosomes
● Follow up erectile hardness score 2.5 out of 4. Shim score of 13
Case #2
● S.B is a 48 year old, white female with history of hypothyroidism, rheumatoid
arthritis. Recent worsening of joint pain and stiffness and swelling of upper
and lower extremities
● Treated with 1cc Exosomes IV and Thymosin Alpha IV
● Results pending
Case #3
● M.S. is a 59 year old, physician in good health with a peripheral neuropathy
thought to be secondary to Levaquin therapy
● Pain in lower extremities is constant and fluctuates from 5 out of 10 to 9 out
of 10; worse with sitting
● Treated with 1ml Exosome/Thymosin Beta and BPC 157 IV followed by 1cc
Exosome IV one week later
● Results pending
Case #4
● L.O is an 89 year old fit, white male who suffered a CVA in October 2018. Only
residual deficit were fatigue and memory loss
● Energy 2 out of 10. Cognitive testing poor performance on memory sections
● Patient treated with 2mL Exosomes IV two-months after event
● Follow-up two-months after treatment; energy 7 out of 10
Anyang Wei, Fengzhi Chen, Haibo Zhang, Zhigiang Wang, Wei Ding, Qinyu Zeng, Wenbin Liu, Can Huang, and Shuhua He. PD49-04
Adipose3-derived Stem-cell Derived Exosomes Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes. Journal of
Urology; Sexual Function/Dysfunction: Basic Research & Pathophysiology 1 Apr 2018.
Hongqi Xin, Yi Li, Michael Chopp. Exosomes/miRNAs as Mediating Cell-based Therapy of Stroke.
Hongqi Xin, Yi Li, Yisheng Cui, James J Yang, Zheng Gang Zhang and Michael Chopp. Systemic administration of exosomes released
from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. Journal of Cerebral
Blood Flow & Metabolism (2013) 33, 1711-1715.
John Burke, Ravindra Kolhe, Monte Hunter, Carlos Isales, Mark Hamrick, and Sadanand Fulzele Stem Cell-Derived Exosomes: A
Potential Alternative Therapeutic Agent in Orthopaedics. Stem Cells Int. 2016; 2016: 5802529. Published online 2016 Jan 19.
Kang Lu, Hai-yin Li, Kuang Yang, Jun-long Wu, Xiao-wei Cai, Yue Zhou, and Chang-qing Li. Exosomes as potential alternatives to
stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone
marrow mesenchymal stem cells. Stem Cell Res Ther. 2017; 8: 108. Published online 2017 May 10.
MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of
cavernous nerve injury. Stem Cell Res Ther. 2018 Sep 26;9(1):246.
Shiue SJ, Rau RH, Shiue HS, Hung YW, Li ZX, Yang KD, Cheng JK. Mesenchymal stem cell exosomes as a cell-free therapy for nerve
injury-induced pain in rats. Pain. 2019 Jan;160(1):210-223.
Ye Xiong, M.D., Ph.D., Asim Mahmood and Michael Chopp. Emerging Potential of Exosomes for Treatment of Traumatic Brain
Injury. Neural Regen Res. 2017 Jan; 12(1); 19-22.
Charleston, South Carolina
Charlotte, North Carolina
Better Life Carolinas
Age Management Wellness Center
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