Mechanisms of Mutation Learning Objectives • Describe the mechanisms of mutations • Study the Hugo de Vries mutation theory Mechanisms of Mutation Learning Objectives • Describe the mechanisms of mutations • Study the Hugo de Vries mutation theory Hugo de Vries • Knew about Mendel’s work • Professor of Botany in Amsterdam • Strong proponent of ______________________________________ • Theory of __________________ • Species evolved from other species due to sudden large changes in traits • Studied Oenothera lamarckiana • Variations due to chromosomal mutations not gene mutations. Hugo de Vries • Knew about Mendel’s work • Professor of Botany in Amsterdam • Strong proponent of ______________________________________ • Theory of __________________ • Species evolved from other species due to sudden large changes in traits • Studied Oenothera lamarckiana • Variations due to chromosomal mutations not gene mutations. Types of Mutations • Chromosomal (from last term) • Gene • Point (______________________) • Silent: No effect on protein (amino acid sequence) • Missense: Change to the amino acid produced in translation • ________________: Premature STOP to translation. • Frameshift • Insertion: addition of a base • Deletion: _______________ of one base • Duplication: repeat of DNA sequence Types of Mutations • Chromosomal (from last term) • Gene • Point (______________________) • Silent: No effect on protein (amino acid sequence) • Missense: Change to the amino acid produced in translation • ________________: Premature STOP to translation. • Frameshift • Insertion: addition of a base • Deletion: _______________ of one base • Duplication: repeat of DNA sequence Some Vocabulary Mutation Chromosomal Mutation Frameshift Nonsense Evolution Mechanism Protein Sickle Cell Anemia Nondisjunction Point Gene Mutation Missense Silent DNA Amino Acid Translation Hugo de Vries Mutation Theory of Evolution Some Vocabulary Mutation Chromosomal Mutation Frameshift Nonsense Evolution Mechanism Protein Sickle Cell Anemia Nondisjunction Point Gene Mutation Missense Silent DNA Amino Acid Translation Hugo de Vries Mutation Theory of Evolution
