RATHOD KARAN D*, GHATE MANJUNATH, PARIKH PALAK
Institute of Pharmacy, Nirma University
17mph403@nirmauni.ac.in
Naturally occurring compounds are well recognized candidates for the anti-cancer curing, management and prevention.
Phytochemicals are a comprehensive field as these are usual, secured, environmental friendly, cheap, and lesser toxicity profile relative to usual anti-cancer treatment methods.
Phytochemicals are selective in their functions and acts explicitly on tumor cells without affect collateral damage. Being an intricate phenomena carcinogenesis incorporates several signaling pathways. Due to our interest in the detection of novel anticancer natural agents for combating the restrictions of cell toxicity and adverse reactions, numerous natural antineoplastic agents are significantly acknowledged e.g. curcumin, resveratrol, etoposide, vinblastine etc. Flavonoids comprises of two benzene rings attached through the straight threecarbon chain and forms an oxygenated heterocycle (C
6
-C
3
-C
6
) that is pyran ring and their large number arises from the various amalgamations of varied hydroxyl, methoxyl, and O-glycoside group substituents on the basic benzo(
ϒ
)pyrone (C
6
-C
3
-C
6
) skeleton. The capacity of flavonoids to alter the CYP1 (cytochrome P450 1) and ABC (ATP binding cassette) protein families, in carcinogenesis. Flavonoids have found to induction of programmed cell death (apoptosis) and the cellular differentiation, cell cycle apprehend, retardation of carcinogens, antiproliferation, inhibition of angiogenesis, antioxidative activity and turnaround of multidrug resistance.
Flavonoids have shown the positive response in the discrete cancer subtypes like oral, cancer, breast and thyroid cancers. The review principally sheds light on the anti-neoplastic action of flavonoids along with its derivatives through mechanisms undergone for the treatment of cancer.