EVA R. CHIN
Assistant Professor
School of Public Health
University of Maryland
College Park, MD 20740
Ph (301) 405-2478
Fax (301) 405-5578
Cell (860) 405-4336
e-mail: erchin@umd.edu
EDUCATION
1989-1993
1987-88
1985-87
1981-85
University of Waterloo
Faculty of Applied Health Sciences
Queens University
Faculty of Education
McMaster University
Adapted Human Biodynamics
Program
University of Windsor
Faculty of Human Kinetics
Ph.D.
B.Ed.
M.Sc.
Exercise Physiology
B.H.K.
SOCIETY MEMBERSHIPS
American Physiological Society
American College of Sports Medicine
OTHER PROFESSIONAL ACTIVITIES
Journal Review Panels
1999-2001
Editorial Review Board, Journal of Applied Physiology
1996-present
Reviewer, Journal of Applied Physiology
1996-present
Reviewer, Canadian Journal of Physiology and Pharmacology
1994-2000
Reviewer, Plugers Archiv
1998-present
Reviewer, Journal of Physiology
2001-present
Reviewer, American Journal of Physiology
2005-present
Reviewer, Molecular Biology of the Cell
2009-present
Reviewer, PLoS One
Grant Review Committees
1999-2000
Reviewer, Australian Research Council
2002-2006
Grant Review Committee member (Integrated Animal Biology) for Natural Science
Engineering & Research Council of Canada (NSERC)
2009-2011
Member, Vanier Canada Graduate Scholarship Selection Committee (NSERC)
2009-2012
Member, Movement and Exercise Grant Review Committee, Canadian Institutes of
Health Research (CIHR)
2013-present
Member, Vanier Graduate Scholarship Selection Committee (CIHR)
RESEARCH EXPERIENCE
September 2008 – current
University of Maryland, College Park: Assistant Professor
 Established new research lab focused on Molecular Basis of Muscle
Function.
 Research lab currently focusing on single muscle fibre contractility
and Ca2+ imaging. Model system being used to investigate
mechanisms underlying muscle dysfunction with aging, muscular
dystrophy and neurodegenerative diseases (i.e. ALS, SMA). Based
on mechanisms of the disease we are evaluating treatments (exercise,
diet and pharmacological strategies) that will attenuate these
impairments.
 Research also focusing on basic cellular and molecular mechanisms
regulating fast and slow muscle fibre-type specific gene expression
using cell culture models.
 Translational research with Dr. Andrew Goldberg, MD, VA Medical
Center Baltimore , investigating changes in human muscle
glycoproteins in diabetic subjects and reversal of glycoprotein
accumulation with exercise intervention.
 Evaluating muscle regenerative capacity using muscle-derived
satellite cells and its application to: i) muscle tissue bioengineering
for development of a small molecule screening platform and ii)
muscle repair under disease or injury conditions.
April 2006 – August 2008
Pfizer Global Research & Development (Groton labs): Associate Director
Global Project Management: Cardiovascular & Metabolic Disease
 support Research Candidate Management Teams in planning, conducting
and reviewing data from clinical trails for novel proprietary compounds in
obesity, osteoporosis and frailty
April 2004 – April 2006
Pfizer Global Research & Development (La Jolla labs): Principal Scientist
Research Pharmacology (Diabetes & Obesity)
 Lead a small group of scientists conducting in vitro and in vivo
pharmacological studies aimed at identifying small molecule and
antibody-based therapies that are efficacious at lowering blood glucose
 Focus on mechanisms for overcoming fatty acid-induced insulin
resistance in muscle, adipose and liver through targeting MAPK
signalling pathways and for increasing muscle mass by targeting
myostatin signalling
 In vitro assay development includes Cellomics nuclear translocation
assays, Meso Scale Discovery phosphoprotein assays (include multi-spot
arrays) and 3H 2-deoxyglucose uptake assays in myocytes and 3T3-L1
adipocytes
 In vivo studies include use of ob/ob, db/db and KKAy/a models of
diabetes for efficacy and biomarker outcomes
December 1999 – April 2004
Pfizer Global Research & Development (Groton labs): Senior Research
Scientist (Frailty Biology)
 Focused on identifying novel targets for drug discovery in new area of
age-related muscle wasting (sarcopenia)






Utilized micro-array and proteomics technologies, adenovirus and siRNA
approaches as well as transgenic and knockout mouse models for target
identification and validation
Developed cell-based assays for moderate throughput screens of
proprietary compounds including Cellomics-based nuclear translocation
assays
Developed in vivo models for assessing motor performance to establish
pre-clinical efficacy of clinical candidates; included use of genetically
modified mice, ob/ob, and mdx mice
Established fluorescence microscopy technique for assessing myocyte
intracellular Ca2+ levels in aged and atrophied muscle
Focused on myostatin and IGF-1 signaling pathways
Managed external grants to academics including Dr. Karyn Esser
(University of Illinois at Chicago; now at University of Kentucky), Dr.
George Ordway (University of Texas Southwestern Medical Center at
Dallas), Dr. Richard Harvey (Victor Chang Cardiac Research Institute,
Sydney Australia) and Professor David Allen (University of Sydney)
July-December 1999
University of Queensland: Lecturer
 Set up research lab to investigate the molecular basis for skeletal muscle
adaptation to exercise training.
 Established cell culture model for investigating Ca2+ -dependent pathways
of gene expression using quantitative rt-pcr
 Held three internal grants funded through the Australian Research
Council (~ $60,000 per yr)
October 1996-June 1999
University of Texas Southwestern Medical Center: Research Fellow
 Investigated the molecular basis for fibre-type specificity of gene
expression in skeletal muscle
 Developed expertise in techniques of molecular biology which can be
applied to understanding the molecular basis of muscle plasticity,
including: DNA cloning, tissue culture work, gene transfection,
generation of transgenic mice, genotyping using southern blot and PCR
screening and gene expression analysis using RT-PCR, northern blot and
western blot techniques
 Established expertise in Ca2+ -dependent pathways of regulating muscle
gene expression including use of cell-based and transgenic mouse models
August 1993-October 1996
University of Sydney, NH&MRC Research Officer
2+
 Investigated the regulation of intracellular Ca in isolated single fibres
during muscle fatigue
 Trained in techniques of micro-dissection, micro-injection and the use of
fluorescent dyes and caged compounds for single cell analysis
 Developed expertise in the role of intracellular Ca2+ in both acute and
prolonged muscle fatigue
Sept. 1989-July 1993
University of Waterloo, Ph.D. Candidate
 Modified and implemented several techniques for assessing skeletal
muscle membrane function
2+
 Co-ordinated research into sarcoplasmic reticulum Ca regulation during
muscle fatigue
September 1985September 1987
McMaster University, M.Sc. Candidate
Supervisors: Dr. J.D. MacDougall and Dr. G.J.F. Heigenhauser
 Design and completion of thesis research investigating ionic and
metabolic regulation in inactive skeletal muscle
May 1983September 1983
University of Windsor, Summer Research Assistant

Assistance with experiments investigating myosin ATPase plasticity
during compensatory hypertrophy in rat skeletal muscle
TEACHING & SUPERVISORY EXPERIENCE
January 2009 – current
January - May 2007
& January-May 2008
December 1999August 2008
University of Maryland, College Park
 Teaching courses in Exercise Physiology cluster
 Undergraduate courses (3): KNES497 Senior Thesis Research,
KNES497-0104 Adaptations of Skeletal Muscle with Disease and
Exercise Training; KNES498I Advanced Applied Physiology and
KNES498N Skeletal Muscle Physiology in Exercise and Disease
 Graduate course: KNES691 Muscular Aspects of Exercise Physiology
 Undergraduate on-line and hybrid course KNES498N and KNES498NWB Skeletal Muscle Physiology in Exercise and Disease
Connecticut College
 Adjunct Professor for Human Physiology undergraduate course.
 Course designed as a studio class with mini-lectures, lab activities, group
discussion and presentation.
 Focus is problem-based learning.
Pfizer Global Research & Development


Supervise research associates involved in developing high throughput
screening assays, cell-based signalling assays, analysis of tissues ex vivo for
signalling proteins and gene expression and in vivo drug screening
Trained and supervised undergraduate students during summer research
internships
July - December 1999 University of Queensland
 Lectured undergraduate and graduate students in exercise physiology course
 Co-ordinated undergraduate and graduate level exercise physiology laboratory
course
November 1997June 1999
UT Southwestern Medical Center


June-July 1998
Lead team project investigating the role of calcineurin in the regulation of gene
expression and hypertrophic growth in skeletal muscle
Supervised 2 full-time and 1 part-time technical staff and 1 graduate student
UT Southwestern Medical Center

August 1994 October 1995
University of Sydney


December 1992July 1993
Training and supervision of rotating medical student during summer research
experience
Casual lecturer in graduate course in Applied Physiology - Exercise Sports
Science/Sports Physiology
lecturer for topics of metabolic regulation and muscle fatigue
University of Waterloo


Lectured in undergraduate and graduate courses in exercise and muscle
physiology
Representative of Graduate Student Association on committee set up by the
University President to evaluate the use and needs of the students physical activity
complex
Academic Supervisory Experience
Graduate Students
Current:
1. Dapeng Chen (PhD)
2. Davi A.G. Mazala (PhD)
3. Alicia DeRusso (MA)
Previous:
4. Davi A.G. Mazala (MA, May 2011)
Thesis: The role of excitation-contraction coupling failure in muscle fatigue
and weakness of dystrophic mice
5. Sam A. English (MA, June 2012)
Thesis: Alterations in the myogenic capacity of satellite cells in a mouse
model of ALS
Undergraduate Students
Current:
1. Jessica Moy (Kinesiology Honor’s Program)
2. Joshua Schimmel (Kinesiology Honor’s Program)
3. David Amici (Kinesiology Honor’s Program)
4. Matthew Liu (Physiology & Neurobiology)
Previous:
1. Pai Han Cheng (Physiology & Neurobiology); currently a Research Assistant
2. Brad Antlitz (Kinesiology); currently Physiotherapy Assistant
3. Daphney Clermont (Microbiology May 2012; currently Research Associate at NIH)
Undergraduate Thesis: Evaluation of the effects of gingerol on skeletal muscle
satellite cell function in vitro
4. Spencer Bonar (BSc Physiology & Neuroscience May 2012; medical school
applicant)
5. Sumeet Gupta (BSc Neuroscience & Business May 2011; currently Medical
Student, University of Virginia)
Undergraduate Thesis: Impaired regenerative capacity of muscle satellite cells
from a mouse model of Amyotrophic Lateral Sclerosis
6. Avi Blumenthal (B.Sc. Kinesiology); MCUR student.
7. Brittany Jacobs (BSc. Kinesiology May 2010; currently PhD candidate,
University of Wisconsin, Madison)
Undergraduate Thesis: Role of Ca2+ signaling pathways in the regulation of
fast versus slow twitch muscle gene expression
8. Andrew Bauder (BSc U. Penn 2010; UG Intern Summer 2009); currently in
Medical School University of Pennsylvania
9. Cathy Saenz (B.Sc. Kinesiology 2009; M.Sc. U Connecticut; currently Ph.D.
student at U of Connecticut)
10. Shannon Brown (B.Sc. Kinesiology 2009; Currently in Veterinary Medicine,
Virginia Tech)
Thesis/Dissertation Examination Committees
2000
Thomas J. Hawke, University of Guelph
Ph.D. Dissertation: Intracellular calcium’s role in methylxanthine-induced changes in
potassium uptake in mammalian skeletal muscle
Oral and written thesis examination
2001
2005
Francois M. Viau, Laurentian University
M.Sc. Thesis: The role of Ca2+ and calcineurin in regulating the myofibrillar and
metabolic properties of individual skeletal muscle fibres
Written thesis examination
Nicole Stupka, University of Melbourne
Ph.D. Dissertation: The calcineurin signal transduction pathway in muscular
dystrophy and skeletal muscle regeneration.
Written thesis examination
2007
Joseph Eibl, Laurentian University
M.Sc. Thesis: Deciphering the calcineurin/NFAT pathway in the hypertrophy and
fiber type conversions of skeletal muscle
Oral and written thesis examination
2009
Ryan Sheppard, University of Maryland
Ph.D. Dissertation: Effects of androgen receptor polyglutamine repeat on
C2C12 cell cycle and gene expression
Thesis Committee Member; Oral and written thesis examination
2010
Mallory Marshall, University of Maryland
M.A. Thesis: The effects of diet and physical activity on telomere length and
telomere-related genes in mice bred for high voluntary wheel running
Thesis Committee Member; Oral and written thesis examination
2011
Erik Hanson, University of Maryland
Ph.D. Dissertation: Can strength training improve musculoskeletal health and
body composition in black men with prostate cancer on androgen deprivation
therapy?
Thesis Committee Member; Oral and written thesis examination
2011
Andrew T. Ludlow, University of Maryland
Ph.D. Dissertation: Telomere dynamics and regulation: Effects of chronic exercise,
acute exercise and oxidative stress
Thesis Committee Member; Oral and written thesis examination
2011
Davi A.G. Mazala
M.A. Thesis: The role of excitation-contraction coupling failure in muscle fatigue and
weakness of dystrophic mice
Thesis Committee Chair; Oral and written thesis examination
2012
Lindsay Wohlers
Ph.D. Dissertation: Reductions in estrogenic function lead to metabolic dysfunction
in adipose tissue and skeletal muscle
Thesis Committee Member; Oral and written thesis examination
2012
Sam A. English
M.A. Thesis: Alterations in the myogenic capacity of satellite cells in a mouse
model of ALS
Thesis Committee Chair; Oral and written thesis examination
2012
Michael P. Morini
M.A. Thesis: Effects of chronic exercise on global DNA methylation and
epigenetic factors in sperm and testes of mice.
Thesis Committee Member; Oral and written thesis examination
2013
Katherine Jackson
Ph.D. Dissertation: Breast cancer type 1 susceptibility protein is a critical regulator of
skeletal muscle lipid metabolism.
Thesis Committee Member; Oral and written thesis examination
2014
Lisa Guth
Ph.D. Dissertation: The effects of exercise ancestry on health-related traits in two
generations of mouse offspring
Thesis Committee Member; Oral and written thesis examination
PUBLICATIONS
Refereed Publications
1. Chin, E.R., M.I. Lindinger and G.J.F. Heigenhauser. (1991). Lactate metabolism in inactive skeletal
muscle during lactacidosis. American Journal of Physiology 261 (Regulatory Integrative Comp. Physiol.
30): R98-R105.
2. Green, H.J., M. Ball-Burnett, E.R. Chin and D. Pette. (1993). Time dependent increases in Na+/K+
ATPase content of chronically stimulated rabbit muscle. FEBS, 310(2): 129-131).
3. Green, H.J., E.R. Chin, M. Ball-Burnett and D. Ranney. (1993). Increases in human skeletal muscle Na+K+ ATPase pump concentration with short term training. American Journal of Physiology, 264 (Cell
Physiol. 33): C1538-C1541.
4. Chin, E.R. and H.J. Green. (1993). Fibre type differences in Na+ -K+ ATPase concentration of rat skeletal
muscle are related to oxidative potential. Canadian Journal of Physiology and Pharmacology, 71(8): 615618.
5. Dossett-Mercer, J., H.J. Green, E. Chin and F. Grange. (1994). Preservation of sarcoplasmic reticulum
2+
Ca sequestering function in homogenates of different fibre type composition following sprint activity.
Canadian Journal of Physiology and Pharmacology, 72: 1231-1237.
6. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer and P.J. O'Brien. (1994). Technical considerations for
2+
assessing alterations in sarcoplasmic reticulum Ca sequestration function in vitro. Molecular and Cellular
Biochemistry, 139: 41-52.
7. Dossett-Mercer, J., H.J. Green, E.R. Chin and F. Grange. (1995). Failure of short term stimulation to
2+
reduce sarcoplasmic reticulum Ca ATPase function in homogenates of rat gastrocnemius. Molecular and
Cellular Biochemistry, 146(1): 23-33.
8. Chin, E.R., H.J. Green, F. Grange, J. Dossett-Mercer and P.J. O'Brien. (1995). Effects of prolonged low
frequency stimulation on skeletal muscle sarcoplasmic reticulum. Canadian Journal of Physiology and
Pharmacology, 73: 1154-1164.
9. Chin, E.R. and H.J. Green. (1996). Effects of tissue fractionation on exercise-induced alterations in
sarcoplasmic reticulum function in rat gastrocnemius muscle. Journal of Applied Physiology, 80(3): 940948.
2+
10. Chin, E.R. and D.G. Allen. (1996). The role of elevations in intracellular [Ca ] in the development of
low frequency fatigue in mouse single muscle fibres. Journal of Physiology, 491.3: 813-824.
11. Allen, D.G., C.D. Balnave and E.R. Chin (1996). Intracellular calcium release and
[Review]. Today’s Life Sciences. Vol. 8 (9): 12-17.
muscle fatigue.
12. Chin, E.R., M.I. Lindinger, and G.J.F. Heigenhauser. (1997). Distribution of lactate and other ions in
inactive skeletal muscle: Influence of hyperkalemic lactacidosis. Canadian Journal of Physiology and
Pharmacology, 75: 1375-1386.
13. Chin, E.R., C.D. Balnave and D.G. Allen. (1997). The role of intracellular calcium and metabolites in low
frequency fatigue of mouse skeletal muscle. American Journal of Physiology. 272 (Cell Physiology 41):
C550-C559.
2+
14. Chin, E.R. and D.G. Allen. (1997). The effects of reduced muscle glycogen concentration on force, Ca
release and contractile protein function in intact mouse skeletal muscle. Journal of Physiology. 498: 587600.
15. Chin, E.R. and D.G. Allen. (1998). The contributions of pH-dependent mechanisms to fatigue at different
workloads in mammalian single muscle fibres. Journal of Physiology. 512: 831-840.
16. Chin, E.R., E.N. Olson, J.A. Richardson, Q. Yang, C. Humphries. J.M Shelton, H. Wu, W. Zhu, R.
Bassel-Duby and R.S. Williams. (1998). A calcineurin-dependent transcriptional pathway controls
skeletal muscle fiber type. Genes & Development 12: 2499-2509.
17. Garry, D.J., G.A. Ordway, J.N. Lorenz, N.B. Radford, E.R. Chin, R.W. Grange, R. Bassel-Duby and R.S.
Williams. (1998). Mice without myoglobin. Nature. 395: 905-908.
18. Ordway, G.A., P. D. Neufer, E. R. Chin, and G. N. DeMartino. (2000). Chronic contractile activity
upregulates the proteasome system in rabbit skeletal muscle. J. Appl. Physiol. 88: 1134-1141.
19. Wu, H., F.J. Naya, T.A. McKinsey, B. Mercer, J.M. Shelton, E.R. Chin, A.R. Simard, R.N. Michel, R.
Bassel-Duby, E.N. Olson and R.S. Williams. (2000). MEF2 responds to multiple calcium-regulated signals
in the control of skeletal muscle fiber type. Embo J. 19(9): 1-11.
20. Dunn, S.E., E.R. Chin & R.N. Michel. (2000). Matching of calcineurin activity to upstream effectors is
critical for skeletal muscle fiber growth. J. Cell. Biol. 151(3): 1-10.
21. Grange, R.W., A. Meeson, E.R. Chin, K.S. Lau, J.T. Stull, J.M. Shelton, R.S. Williams & D.J. Garry.
(2001). Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. Am. J.
Physiol. 281(5): C1487-C1494.
22. Chin, E.R., R.W. Grange, R.F. Viau, R.S. Bassel-Duby, R.N. Michel and R.S. Williams. (2003a).
Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein
parvalbumin. J. Physiol. 547: 649-663.
23. Chakkalakal, J.V., M.A. Stocksley, M.A. Harrison, L.M. Angus, J. Deschenes-Furry, S. St.Pierre, L.A.
Megheny, E.R. Chin, R.N. Michel and B.J. Jasmin. (2003). Expression of utrophin A mRNA correlates
with the oxidative capacity of skeletal muscle fibre types and is regulated by calcineurin. PNAS 100:
7791-7796.
24. Chakkalakal, J.V., M.A. Harrison, E.R. Chin, R.N. Michel and B.J. Jasmin. (2004). Stimulation of
calcineurin signalling attenuates the dystrophic pathology in mdx mice. Human Molecular Genetics 13(4):
379-388.
25. Chin, E.R. (2004). The role of Ca2+ and the Ca2+/calmodulin-dependent kinases in skeletal muscle
plasticity and mitochondrial biogenesis. Proceedings of the Nutrition Society. 63: 279-286.
26. Michel, R.N., S.E. Dunn and E.R. Chin. (2004). Calcineurin and muscle growth. Proceedings of the
Nutrition Society. 63: 341-349.
27. Hornberger, T.A., R. Stuppard, K.E. Conley, M. Fedele, M.L. Fiorotto, E.R. Chin and K.A. Esser.
(2004). Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide-3-kinase,
protein kinase B and growth factor independent mechanism. Biochemical Journal. 380: 795-804.
28. Hornberger, T.A., R.D. Mateja, E.R. Chin, J.L. Andrews and K.A. Esser (2005). Aging does not alter the
mechanosensitivity of the p38, p70S6k and JNK2 signaling pathways in skeletal muscle. J. Appl. Physiol.
98: 1562-1566.
29. Chin, E.R. (2005). The role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity. J. Appl.
Physiol. 99(2): 414-23.
30. Angus, L.M., J.V. Chakkalakal, A. Mejat, J.K. Eibl, G. Belanger, L.A. Megheny, E.R. Chin, L. Schaeffer,
R.N. Michel and B.J. Jasmin. (2005). Calcineurin/NFAT signaling, together with GABP and PGC-1,
drives utrophin gene expression at the neuromuscular junction. Am. J. Physiol. Cell Physiol. 289: C908C917.
31. Chakkalakal, J.V., S.A. Michel, E.R. Chin, R.N. Michel and B.J. Jasmin. (2006). Targeted inhibition of
Ca+2/calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle. Hum. Mol. Gen.
15: 1423-1435.
32. Michel, R.N., E.R. Chin, J.V. Chakkalakal, J.K. Eibl and B.J. Jasmin. (2007). Ca2+/Calmodulin-based
signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of
utrophin A and myostatin expression. Appl. Physiol. Nutr. Metab. 32: 921-929.
33. Cairns, S., E.R. Chin and J.M. Renaud. (2007). Stimulation pulse characteristics and electrode
configuration determine site of excitation in isolated mammalian skeletal muscle: Implications for fatigue.
J. Appl. Physiol. 103: 359-368.
34. Chin, E.R. (2010). Intracellular Ca2+ signaling in skeletal muscle: Decoding a complex message. Exerc.
Sport Sci. Rev. 38(2): 76-85.
35. Sheppard, R.L., E.E. Spangenburg, E.R. Chin, S.M. Roth. (2011). Androgen receptor
polyglutamine repeat length affects receptor activity and C2C12 cell development. Physiol. Gen.
43: 1135-1143.
36. Wohlers, L.M., Powers, B.L., Chin, E.R. and E.E. Spangenburg. (2013). Using a novel coculture model to dissect the role of intramuscular lipid load on skeletal muscle insulin
responsiveness under reduced estrogen conditions. Am J Physiol Endocrinol Metab. 304(11):
E1199-212.
37. Ludow, A.T., Spangenburg, E.E., Chin, E.R., Cheng, W-H and S.M. Roth. (2014). Telomeres
shorten in response to oxidative stress in mouse skeletal muscle fibers. Gerontol A Biol Sci Med
Sci. 69(7):821-30.
38. Bamman, M.M., F.W. Booth, E.R. Chin, P.D. Neufer, S. Trappe, J.T. Lightfoot, D.M. Cooper,
W.E. Kraus and M.J. Joyner. (2014). Exercise biology and medicine: innovative research to
improve global health. Mayo Clin Proc. 89(2):148-53.
39. Chin, E.R., D.A.G. Mazala, K. Bobyk and D. Chen. Perturbations in Intracellular Ca2+ Handling
in Skeletal Muscle of a Mouse Model of Amyotrophic Lateral Sclerosis. (2014) Am J Physiol
Cell Physiol. 307(11): C1031-C1038.
40. Mazala DA, Grange RW, Chin ER. (2015). The role of proteases in excitation-contraction
coupling failure in muscular dystrophy. Am J Physiol Cell Physiol. 308(1): C33-C40.
Published Abstracts/Conference presentation
1. Galea, V., E.R. Freisinger, M.I. Lindinger and G.F.J. Heigenhauser. (1987). Effects of lactacidosis
on skeletal muscle ion regulation. Medicine and Science in Sports and Exercise. Suppl. 19(2): S35.
2. Freisinger, E.R., M.I. Lindinger, V. Galea and G.J.F. Heigenhauser. (1987). Effects of lactacidosis
on resting skeletal muscle metabolism in isolated perfused rat hindlimb. Medicine and Science in
Sports and Exercise. Suppl. 19(2): S54.
3. Freisinger, E.R., M.I. Lindinger, V. Galea, J.D. MacDougall and G.J.F. Heigenhauser. (1987).
Effects of arterial lactacidosis on fat and carbohydrate metabolism in inactive skeletal muscle.
Canadian Journal of Sport Sciences. 12(3): 7P.
4. Chin, E.R., M.I. Lindinger and G.J.F. Heigenhauser. (1990). Effects of lactacidosis on ionic flux
across inactive skeletal muscle. Canadian Journal of Sport Sciences. 15(4): 7S.
5. Chin, E.R. and H.J. Green. (1991). Fibre type differences in Na+ -K+ ATPase concentration of rat
skeletal muscle are related to oxidative potential. Medicine and Science in Sports and Exercise. Suppl.
23(4): S23.
6. Chin, E.R., H.J. Green, M. Ball-Burnett and D. Ranney. (1992). Training induced changes in
sarcolemmal Na+ -K+ pump concentration in human skeletal muscle. Medicine and Science in Sports
and Exercise. Suppl. 24(5): S106.
7. Green, H.J., F. Grange, E.R. Chin, C. Goreham, D. Ranney and R.J. Xiu. (1992). Alterations in
2+
sarcoplasmic reticulum Ca ATPase activity in human skeletal muscle with prolonged exercise. The
Physiologist. 35(4): 215.
8. Chin, E.R., F. Grange, J.D. Mercer and P.J. O'Brien. (1992). Technical considerations for assessing
skeletal muscle sarcoplasmic reticulum function following exercise. The Physiologist. 35(4): 215.
9. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer, P.J. O'Brien. (1993). Functional impairment of
2+
2+
sarcoplasmic reticulum Ca -Mg ATPase in vitro is related to altered membrane yield following
prolonged running. The FASEB Journal. 7(3): A226.
10. Dossett-Mercer, H.J. Green, E.R. Chin, F. Grange and P.J. O'Brien. (1993). Lack of an effect of short
2+
2+
term stimulation on sarcoplasmic reticulum Ca uptake and Ca ATPase activity in homogenates of
rat red and white gastrocnemius. Medicine and Science in Sports and Exercise. Suppl. 25(5): S177.
11. Chin, E.R., H.J. Green, F. Grange, J.D. Mercer, P.J. O'Brien. (1993). Muscle fatigue in situ is
independent of altered sarcoplasmic reticulum function in vitro following prolonged electrical
stimulation. Medicine and Science in Sports and Exercise. Suppl. 25(5): S19
2+
12. Chin, E.R. and H.J. Green. (1994). Skeletal muscle Ca ATPase activity in heavy and light
sarcoplasmic reticulum fractions following treadmill running. Proceedings of the Australian
Physiological and Pharmacological Society. 25(1): 25P.
13. Chin, E.R., F. Grange and H.J. Green. (1994). Calcium uptake in heavy and light sarcoplasmic
reticulum of skeletal muscle following treadmill running. Proceedings of the Australian Physiological
and Pharmacological Society. 25(2): 114P.
14. Chin, E.R. and D.G. Allen. (1995). Effects of caffeine and tetanic stimulation on the force-frequency
relationship in isolated single muscle fibres. Proceedings of the Australian Physiological and
Pharmacological Society. 26(1): 27P.
15. Chin, E.R. and D.G. Allen. (1995). Raised intracellular calcium can cause subsequent failure of
calcium release in mammalian skeletal muscle. Proceedings of the Physiological Society Oxford
Meetings. 41P.
2+
16. Chin, E.R. and D.G. Allen. (1995). The role of substrate supply and Ca release in
fatigue
resistance of mouse single skeletal mouse single skeletal muscle fibres. Proceedings of the Australian
Physiological and Pharmacological Society. 26(2): 124P.
17. Chin, E.R. and D.G. Allen. (1996). Alterations in myofibrillar protein function associated with
glycogen depletion in mouse skeletal muscle. Proceedings of the Australian Physiological and
Pharmacological Society. 27(1): 59P.
2+
18. Chin, E.R. and D.G. Allen. (1996). The effects of muscle glycogen depletion on Ca release in single
skeletal muscle fibres. Medicine and Science in Sports and Exercise. Suppl. 28(5): S122.
19. Allen, D.G. and E.R. Chin. (1996). Fatigue in mouse muscle fibres at different work intensities.
Proceedings of the Australian Physiological and Pharmacological Society. 27(2).
20. Allen, D.G., E.R. Chin, and C.D. Balnave. (1996). Modulation of tetanic calcium concentrations in
skeletal muscle during and after exercise. The Physiologist. 39(5): A-62.
2+
21. Chin, E.R. and D.G. Allen. (1996). Changes in intracellular free Ca concentration
during
constant 10 Hz stimulation of mouse single skeletal muscle fibres. The Physiologist. 39(5): A-74.
22. Chin, E.R. and D.G. Allen. (1997). Effects of epinepherine-stimulated glycogenolysis on force and
Ca2+ release in mouse single skeletal muscle fibres. Medicine and Science in Sports and Exercise.
Suppl. 29(5): S272.
23. Chin, E.R. and R.S. Williams. (1998). An RT-PCR-based assay system for examining fiber-type
specific gene expression in skeletal muscle. FASEB Journal. 12(4): A472.
24. Chin, E.R., E.N. Olson, C. G. Humphries., H. Wu, R.S. Bassel-Duby and R.S. Williams. (1998).
Regulation of skeletal muscle fiber-type diversity by a calcineurin-dependent transcriptional pathway.
American Heart Association Meetings.
25. Chin, E.R., R.W. Grange, M.Maier, R.S. Bassel-Duby and R.S. Williams. (1999). Altered contractile
function in slow-twitch muscle from transgenic mice overexpressing parvalbumin. Medicine and
Science in Sports and Exercise. Vol. 31:5 Suppl.
26. Dunn, S.E., A.R. Simard, E.R. Chin and R.N. Michel. (2001). Calcineurin and its upstream activitydependent effectors signal via NFAT and MEF2 to induce skeletal muscle hypertrophy. FASEB
Journal. 15(4): A421.
27. Viau, F., E.R. Chin, R.S. Williams and R.N. Michel. (2001). Alterations in skeletal muscle gene
expression in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. FASEB Journal.
15(4): A420.
28. Chin, E.R., S.E. Dunn, R.N. Michel and R.S. Williams. (2001). Alterations in muscle phenotype in
transgenic mice overexpressing a calmodulin inhibitory peptide regulated by the troponin I slow
promoter. FASEB Journal. 15(4): A421.
29. Chakkalakal, J.V., M.A. Stocksley, J. Deschenes-Furry, E.R. Chin, M.-A. Harrison, R.N. Michel and
B. J. Jasmin. (2003). Expression of Utrophin A mRNA correlates with the metabolic efficiency of
muscle and involves calcineurin. FASEB. J. 17(5): A956.
30. Chin, E.R., F.-W. Bangerter and J.M. Renaud. (2003b). Alterations in intracellular Ca2+ transients in
single muscle fibers from old compared to young rats. FASEB J. 17(5): A1277.
31. Renaud, J.M., J.P. O’Malley and E.R. Chin. (2003). Effect of time in culture on intracellular Ca2+
levels and unloaded shortening velocity. FASEB. J. 17(5): A1275.
32. Hill, R.J., D.B. Rouillard, E.R. Chin, C. Ibebunjo, X.N. Wang, R. Layfield and J.J. Oleynek. (2004).
Age-related muscle atrophy is associated with both an increase in poly ubiquitination and expression
of the muscle-specific E3 ligase MAFbx. FASEB J. 18(4): A346.
33. Genido, J., J.F. Schaefer and E.R. Chin. (2004). Down-regulation of both fast and slow fibre-type
specific genes by myostatin and TGF. The Physiologist. 47 (4): 342.
34. Chin, E.R. and J.F. Schaefer. (2005). Inhibition of Caseine Kinase I increases nuclear NFAT in
C2C12 cells. FASEB J. 19(4): A116.
35. Petras, C.F. and E.R. Chin. (2005). Motor activity in mdx mice is increasingly impaired with age.
FASEB J. 19(4): A573.
36. Muthuri, S.K., E.R. Chin and R.N. Michel. (2007). Myostatin as a putative downstream gene target
of calcineurin signaling associated with muscle growth remodelling. FASEB J. 21: 895.14.
37. Chin, E. R. and J. F. Schaefer. (2008). Inhibition of caseine kinase I increases nuclear NFAT in
C2C12 cells. Meeting Program for the Integrative Biology of Exercise V Meeting. p. 69.
38. Chin, E.R., C. Ibebunjo and M. T McDowell. (2009). A proteomics-based approach to changes in
skeletal muscle gene expression with age-related sarcopenia. FASEB J. 2009 23:954.4.
39. Sheppard, R., E.E. Spangenburg, E.R. Chin and S.M. Roth. (2010). Androgen Receptor CAG repeat
length affects receptor activity and the development of C2C12 myoblasts. Medicine and Science in
Sports and Exercise. Suppl. 42(5): S64.
40. Mazala, D. and E.R. Chin. (2010). Effects of ex vivo denervation on intracellular Ca2+ ratios in intact
mammalian single muscle fibers. Medicine and Science in Sports and Exercise. Suppl. 42(5): S584S585.
41. Chin, E.R., D. Mazala & D. Chen. (2011). Alterations in intracellular free Ca2+ concentrations in
intact single muscle fibres from ALS mice. Experimental Biology Meeting, FASEB J. 25:1051.49.
42. Jacobs, B., D. Chen and E.R. Chin. (2011). C2C12 cell culture model for investigating Ca2+ dependence of myocyte differentiation. Experimental Biology Meeting, FASEB J.
43. Mazala,D., D. Chen & E.R. Chin. (2011). Alterations in excitation-contraction coupling in mouse
models of muscular dystrophy. Experimental Biology Meeting , FASEB J. 25:lb599.
44. Wang, Y., D. Chen, A. P. Goldberg & E.R. Chin. (2011). Screening of protein glycosylation in
human muscle tissue using lectin enrichment and mass spectrometry. ACS Mid-Atlantic Meeting.
45. Chin, E.R., D. A.G. Mazala, & D. Chen (2012). Alterations in Ca2+ regulatory proteins and Ca2+ dependent gene expression in skeletal muscle from ALS mice. Experimental Biology Meeting.
FASEB J. 26:1075.16.
46. Mazala, D.A.G., D. Chen, S.A. English, R.W. Grange & E. R. Chin. (2012) Effects of calpain
inhibition in excitation-contraction coupling properties in dystrophic muscle exposed to fatiguing
contractions. Experimental Biology Meeting. FASEB J. 26:571.3.
47. English. S., S. Gupta, D. Clermont, D. Chen, D.A.G. Mazala & E. R. Chin. (2012) Alterations in the
myogenic capacity of satellite cells in a mouse model of ALS. Experimental Biology Meeting.
FASEB J. 26:1078.28.
48. Chen, D., D.A.G. Mazala, S.A. English & E. R. Chin. (2012). The Role of ER chaperone BiP in the
pathology of ALS. Experimental Biology Meeting. FASEB J. 26:lb783
49. Zein, M.A., E.R. Chin, B.J. Jasmin & R.N. Michel. (2012). Targeted expression of the non-native
Ca2+-buffering protein parvalbumin exacerbates the dystrophic phenotype in mdx mouse slow muscle
fibers. Experimental Biology Meeting. FASEB J. 26:1086.23.
50. Mazala, D.A.G., S. Bonar & E.R. Chin. (2012) Evaluation of calcium clearance between different
mouse models for Duchenne muscular dystrophy. Muscular Dystrophy Association New Directions in
Biology and Disease of Skeletal Muscle Conference. June 17-20, 2012.
51. Chin, E.R., S.J. Prior, Y. Wang, D. Chen, A.S. Ryan, H.K. Ortmeyer, J. Blumenthal, J. Beans and
A.P. Goldberg. (2012). Aerobic Exercise Training Improves Glucose and Lipid Metabolism in T2DM
by Reducing Skeletal Muscle Glycoproteins and Increasing GLUT4, CPT1 and Lipoprotein Lipase
(LPL). Mid-Atlantic Diabetes Symposium.
52. Chen, D., S.J. Prior, Y. Wang, D. Chen, A.S. Ryan, H.K. Ortmeyer, J. Blumenthal, J. Beans, A.P.
Goldberg and E.R. Chin. (2013). Mass spectrometric characterization of protein glycosylation in
skeletal muscle of T2DM after aerobic exercise training. Experimental Biology Meeting. FASEB J.
27:lb703.
53. Mázala, D.A.G, Pratt, S.J.P., Chen, D, Molkentin, J.D., Lovering, R.M. and ER Chin. (2014). Skeletal
muscle damage and contraction-induced torque loss are attenuated in mdx/Utr-/- mice by SERCA1
overexpression. New Directions Conference Proceedings, June 2014.
54. Prior, S.J., Ortmeyer, H.K., Chin, E.R., Chen, D., Blumenthal, J.B., Goldberg, A.P. and A.S. Ryan.
(2014). Increased skeletal muscle capillarization after exercise training enhances insulin sensitivity
independent of insulin signaling and glucose transport mechanisms. ADA Meeting. June 2014.
Manuscripts In Review:
Mazala, D.A.G. and E.R. Chin. The role of calpains in excitation-contraction coupling failure and
weakness in dystrophic skeletal muscle. In Review. Am. J. Physiol. Cell.
Chen, D. and E.R. Chin. GRP78/BiP Deficiency and Endoplasmic Reticulum Stress in Skeletal Muscle of
G93A*SOD1 ALS Mice. In Review. Skeletal Muscle.
Landers-Ramos, R.Q., Sapp, R.M, Jenkins N.T., Murphy, A.E., Cancre, L., Chin, E.R., Spangenburg, E.E.
and Hagberg, J.M. Chronic endurance exercise affects paracrine action of CD31+ and
CD34+ cells on endothelial tube formation. In Review. J. Physiol.
Manuscripts Pending Submission (May-July 2014):
Chen, D., D.A.G. Mazala & E.R. Chin. 6-Gingerol improves skeletal muscle function of G93A*SOD1 ALS
mice. Targeted for J. Cell. Biochem.
Mázala, D.A.G, Pratt, S.J.P., Chen, D, Molkentin, J.D., Lovering, R.M. and ER Chin. Skeletal muscle damage
and contraction-induced torque loss are attenuated in mdx/Utr-/- mice by SERCA1 overexpression. Targeted
for Human Molecular Genetics.
Chen, D., Wang, Y. and E.R. Chin. A mass spectrometry-based method for identification and analysis of Nlinked glycoproteins in human skeletal muscle. Targeted for Molecular and Cellular Biochemistry.
English, S.A. & E.R. Chin. Alterations in the myogenic capacity of satellite cells in a mouse model of
Amyotrophic Lateral Sclerosis. Targeted for Muscle & Nerve.
English, S.A. & E.R. Chin. Defects in myocyte function in Amyotrophic Lateral Sclerosis (Review article).
Targeted for Skeletal Muscle.
Chen, D., Mazala, D.A.G. and E.R. Chin. SERCA1 overexpression attenuates disease progression in the
G93A*SOD1 mouse model of ALS. Targeted for Pflugers Archiv.
Chin,E.R. Adaptive changes in skeletal muscle from G93A*SOD1 mice: Activation of the calcineurin
transcriptional program. Targeted for Neuromuscular Disorders.
Jacobs, B.L., Chen, D. & E.R. Chin. C2C12 cell culture model for investigating Ca2+-dependence of myocyte
differentiation
Manuscripts In Preparation:
Chin, E.R. Chen, D., Wang, Y., Prior, S.J., Ryan, S.J., Ortmeyer, H.K., Blumenthal, J.Beans, J., and. A.P.
Goldberg, A.P. Characterization of protein glycosylation in skeletal muscle of Type 2 diabetics after aerobic
exercise training.
Chin, E.R., D. Chen, L. Ostrow and Y. Wang. A proteomics-based approach to identifying skeletal muscle
protein biomarkers to differentiate ALS from other neuromuscular diseases.
Genido, J. and E.R. Chin. Regulation of fast and slow fibre-type specific genes by myostatin and TGF.
2+
Chin, E.R. and D.G. Allen. Changes in intracellular free Ca concentration during constant 10 Hz stimulation
of mouse single skeletal muscle fibres.
Chin, E.R., F.-W. Bangerter and J.M. Renaud. Alterations in intracellular Ca2+ transients in single muscle
fibers from old compared to young rats.
Renaud, J.M., J.P. O’Malley and E.R. Chin. Effects of denervation on intracellular Ca2+ levels and unloaded
shortening velocity.
Theses
Ph.D.
M.Sc.
2+
Assessment of Sarcoplasmic Reticulum Ca Sequestration in Rat Gastrocnemius Muscle
Following Prolonged Activity
Advisor: Dr. H.J. Green
Completed: August 1993, University of Waterloo, Canada
Effects of Lactacidosis on Muscle Metabolism and Ionic Flux in Inactive Skeletal Muscle of
the Isolated Perfused Rat Hindlimb
Advisor: Dr. J.D. MacDougall
Completed: September 1987, McMaster University, Canada
Patents/Patent Applications:
Eva R. Chin, Jeffery Molkentin, Eric. Olson & R. Sanders Williams. 1999. A method to alter specialized
characteristics of skeletal myofibers.
Eva R. Chin, Chikwendu Ibebunjo, Philip A. Krasney, Junming Yie, Joseph Zachwieja & Larry Green. 2007.
Antibodies to myostatin. WO2006116269 A3.
Eva R. Chin & Dapeng Chen. 2013. Markers for diagnosing Amyotrophic Lateral Sclerosis.
WO2103/155365
Disclosures to UMCP:
LS-2011-111: E.R. Chin, Method for Early Diagnosis of ALS I
LS-2012-046: E.R. Chin & D. Chen, Method for Early Diagnosis of ALS II
LS-2012-109: E.R. Chin, Small molecule therapeutic for the treatment of NMD
LS-2013-134: E.R. Chin, A method for differential diagnosis of ALS and for monitoring disease progression
LS-2013-XXX: J. Hagberg, R. Landers-Ramos, E.R. Chin, E.E. Spangenburg, Novel CD31 and CD34 Stem
Cell Secreteome Proteins Affecting Angiogenesis
INVITED PRESENTATIONS
Invited Seminar Presentations
“Intracellular calcium signalling in striated muscle: Decoding a complex message.” University of Ottawa,
Department of Cellular and Molecular Medicine, Graduate Seminar Series. August 17, 2000.
“Intracellular calcium signalling in striated muscle: Decoding a complex message.” Boston University,
Department of Health Sciences, Graduate Seminar Series. Boston, MA. June 22, 2001.
“Regulation of skeletal muscle gene expression by intracellular calcium signalling.” The Children’s Hospital
at Westmead, Sydney, Australia. August, 28, 2001.
“The role of calcium signalling in skeletal muscle gene expression.” University of Illinois at Chicago, College
of Applied Health Sciences, Graduate Seminar Series. Chicago, IL. October 26, 2001.
“The role of Calcium-dependent signals in skeletal muscle hypertrophy and fibre type adaptations.”
University of California-Irvine, Department of Orthopaedics Seminar Series. Irvine, CA. December 1, 2004.
“The role of Calcium-dependent signals in skeletal muscle hypertrophy and fibre type adaptations.”
Concordia University, Department of Exercise Sciences, Montreal, QC, Canada. February 10, 2006.
“Understanding Ca2+ signaling pathways in skeletal muscle: Could this lead to an exercise pill?” University
of Dundee, Molecular Physiology Group, Dundee, Scotland, UK. July 18, 2007.
“The exercise signal: Decoding a complex message to regulate muscle phenotype.” Children’s National
Medical Center Research Seminars, Washington, DC. June 15, 2009.
“Understanding Ca2+ signaling pathways in skeletal muscle: Could this lead to an exercise pill?” VA Medical
Center, Baltimore, MD. October 22, 2009.
“The role of intracellular Ca2+ in skeletal muscle contraction, damage and muscle disease”. Safety
Pharmacology group, FDA, Silver Spring, MD. November 18, 2010.
“Development of a high throughput bioengineered skeletal muscle array”. BioEngineering, The University of
Maryland, College Park, MD. May 2012.
“Cellular defects in skeletal muscle in ALS: Is the muscle talking back to the nerve?” Seminar presentation
given to Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State
University, Blacksburg, VA, November 2012.
“Cellular defects in skeletal muscle in ALS: Is the muscle talking back to the nerve?” Seminar presentation
given to the School of Physiotherapy and Rehabilitative Sciences, University of Maryland, Baltimore MD,
December 2012.
Invited Conference Presentations
“The role of calcium-dependent transcriptional pathways for regulating skeletal muscle diversity.” Princess
Diana Lecture and Symposium, The Victor Chang Cardiac Research Institute, Sydney, Australia. November
1, 1999
“Calcineurin signalling of gene expression in skeletal muscle.” Gordon Conference on Excitation-contraction
coupling, New London, NH. June 12, 2003
“Role of Calcium and calmodulin kinases in fibre type and mitochondrial biogenesis.” International
Biochemistry of Exercise Meetings, Maastricht, The Netherlands. July 15, 2003.
“Calcineurin and Muscle Growth.” International Biochemistry of Exercise Meetings, Maastricht, The
Netherlands. July 16, 2003.
“Calcium signalling in skeletal muscle: Decoding a complex message.” Howard J. Green Symposium, The
University of Waterloo, Ontario Canada. September 24, 2004.
“The boomerang approach to science: Research across the world and back.” International Union of
Physiological Societies, San Diego, CA. April 3, 2005.
“Ca2+ /Calmodulin-based signaling in the regulation of the muscle fiber phenotype.” International
Biochemistry of Exercise Meeting, Seoul, Korea. October 20, 2006.
“Functional roles of SR, myoplasmic and extracellular calcium in determining force generation.” APS/ACSM
Integrative Biology of exercise Meeting, Hilton Head, SC. September 2008.
“The exercise mimetic: The promise and challenge of replacing exercise with a pill.” ACSM Annual Meeting,
Baltimore, MD June 4, 2010.
“Biomarker identification easing up target and drug discovery”. Orphan Drug Meeting, Washington DC, April
2013.
“The valuable role of exercise scientists to bring treatments to clinical trials”. ACSM Translational Group
Symposium, American College of Sports Medicine Annual Meeting, Indianapolis IN, May 2013.
Symposia Chair:
2004 APS/ACSM Integrative Biology of Exercise Meeting, Austin, TX. “Striated Muscle Hypertrophy:
Factors Controlling Cell Enlargement and Phenotype Transformations”.
2008 APS/ACSM Integrative Biology of Exercise Meeting, Hilton Head, SC. “Signaling Mechanisms
Regulating Metabolic and Transcription Processes in Skeletal Muscle”.
2010 Experimental Biology Meeting, Anaheim, CA. “To Exercise or Not to Exercise: Can we replace physical
activity with a pill?”. Symposium Organizer & Co-Chair.
2011 American College of Sports Medicine Annual Meeting, Denver CO. ACSM Translational Group
Symposium: NCATS: The New Face of NIH Support for Translational Research and its Impact on Exercise
Science. Symposium Co-Organizer & Chair.