Mark C. Siracusa,
May
Curriculum Vitae: MARK C. SIRACUSA, PhD
Work address:
Rutgers New Jersey Medical School
Department of Medicine
Center for Immunity and Inflammation
185 South Orange Ave.
MSB, F-613
Newark, NJ 07103
USA
T. 973.972.1265
E. mark.siracusa@rutgers.edu
Home address:
Princeton, NJ 08540
USA
ACADEMIC POSITIONS
RUTGERS NEW JERSEY MEDICAL SCHOOL
Newark, NJ
Department of Medicine, Center for Immunity and Inflammation • A s s i s t a n t P r o f e s s o r
( t e n u r e - t r a c k ) , C h a n c e l l o r S c h o l a r • May 2014 – present
EDUCATION
JOHNS HOPKINS UNIVERSITY • BLOOMBERG SCHOOL OF PUBLIC HEALTH
Baltimore, MD
W. Harry Feinstone Department of Molecular Microbiology & Immunology,
Doctor of Philosophy • Sept. 2003 - Sept. 2008
MERRIMACK COLLEGE
North Andover, MA
Bachelor of Science Degree, Biochemistry (Honors)• Sept. 1996 - May 2000
RESEARCH EXPERIENCE
POSTDOCTORAL FELLOW
Mentor, David Artis
University of Pennsylvania, Perelman School of Medicine
Department of Microbiology, Institute for Immunology
Philadelphia, PA • Oct. 2008 – present
DOCTORAL THESIS
Mentor, Alan Scott
Johns Hopkins University, Bloomberg School of Public Health
W. Harry Feinstone Department of Molecular Microbiology & Immunology
Baltimore, MD • Aug. 2003 – Sept. 2008
Dissertation: Hookworm Infection Permanently Alters the Pulmonary Environment of Its Host: The Role of
the Alternatively Activated Alveolar Macrophage
SENIOR LABORATORY TECHNICIAN
Dana-Farber Cancer Institute, Harvard Medical School
Boston, MA • June 2000 – Aug. 2003
• Folded HLA restricted peptides
• Provided tetramers for clinical trials
Mark C. Siracusa,
May
• Processed clinical samples
BIOCHEMICAL UNDERGRADUATE RESEARCH
Merrimack College, Research Program
North Andover, MA • May 1999 – June • One of four honor students chosen to participate
• Established and performed unprecedented protocols
TEACHING EXPERIENCE
LECTURER
Rutgers New Jersey Medical School
Courses:
• Advanced Concepts in Infection, Immunity and Inflammation (2014 – present)
An advanced level course that explores the link between infectious and inflammatory disease states.
Lectures provide students with a better understanding of how dysregulated immune responses can
promote chromic inflammation. I present the ‘Innate Immunity” lecture.
LECTURER
University of Pennsylvania, School of Veterinary Medicine
Department of Parasitology
Courses:
• VPTH604 Immunology (2013 – present)
An introductory course in Immunology for students of veterinary medicine. The course is designed to
provide students with a working knowledge of the cellular and molecular mechanisms through which
the immune system regulates the development of inflammation. Lectures are clinically oriented and
provide students with a better understanding of how the immune system can regulate both health and
disease. I present the ‘Mucosal Immunology’ lecture.
• CAMB 549 Parasites and Parasitism (2010 – present)
An advanced level course in parasitology that is offered to students in Cell and Molecular Biology
(CAMB). The course is designed to provide a detailed discussion of the biology of parasitism,
including the evolution of parasites and their adaptations to parasitic life. There is a major focus on
parasites of medical importance and significant discussion of the pathogenesis associated with these
infections. I present the ‘Innate Immunity to Helminth Parasites’ lecture.
• CAMB 696 Microbiology, Virology, and Parasitology (2010 – present)
A new discussion-based class offered to senior level CAMB students from the
Microbiology/Virology/Parasitology (MVP) track. The purpose of this course is to discuss recent
papers in parasitology research. Each week, a guest faculty member chooses a recent paper that is
presented and discussed by the students.
TEACHING ASSISTANT
Johns Hopkins University, Bloomberg School of Public Health
W. Harry Feinstone Department of Molecular Microbiology & Immunology
Courses:
• 260.611
• 260.612
• 260.801
• 260.802
• 260.631
• 260.635
Principles of Immunology I (2004 – 2008)
Principles of Immunology II (2004 – 2008)
Topics in Immunology I (2004 – 2008)
Topics in Immunology II (2004 – 2008)
Immunology, Infection and Disease (2008)
Biology of Parasitism (2006)
Responsibilities:
• Prepared and presented lectures
Mark C. Siracusa,
May
• Designed and graded exam questions
• Led class presentations, discussions and review sessions
• Tutored students on lecture content and current literature
LABORATORY MENTORING
University of Pennsylvania, Perelman School of Medicine
Department of Microbiology, Institute for Immunology
Students: Steven A. Saenz, PhD candidate
Thesis title: The functional biology of IL-25
David A. Hill, MD/PhD candidate
Thesis title: Microbial regulation of allergic inflammation
Responsibilities:
• Assisted with development of thesis objectives
• Established and optimized experimental procedures
• Assisted with data organization and presentation
Johns Hopkins University, Bloomberg School of Public Health
W. Harry Feinstone Department of Molecular Microbiology & Immunology
Students:
Cornelius D. Jamison, Sc.M. candidate, displaced Hurricane Katrina Tulane School of Public Health
student
Thesis title: The innate pulmonary immune response during malaria infection
Sarah Coffman, Sc.M. candidate
Thesis title: Coinfection and immunity in the lung: Helminth modulation of the immune response to
gram-negative bacteria
Responsibilities:
• Designed experiments and established thesis topics and objectives
• Established experimental efficacy and optimized procedures
• Organized data, presentations and thesis
PUBLICATIONS
PEER-REVIEWED JOURNAL ARTICLES
• Siracusa MC, Hill DA, Ruymann KR, Tait Wojno ED, Artis D, and Spergel JM.
Omalizumab therapy is associated with reduced circulating basophil populations in asthmatic children.
Allergy. 2014 [Epub ahead of print]. PMID 24611974
• Noti M, Kim BS, Siracusa MC, Rak GD, Kubo M, Moghaddam AE, Sattentau QA, Comeau MR,
Spergel JM, and Artis D.
Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic
stromal lymphopoietin-basophil axis.
Journal of Allergy and Clinical Immunology. 2014 Feb 19 [Epub ahead of print]. PMID: 245604412
• Siracusa MC, Saenz SA, Tait Wojno ED, Kim BS, Osborne LC, Ziegler C, Benitez AJ, Ruymann KR,
Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, and Artis D.
TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation.
Immunity. 2013 Dec 12, 39(6):1158-70. (PMID 24332033) .
• Saenz SA, Siracusa MC, Monticelli LA, Ziegler CGK, Wherry EJ, Goldrath AW, Bhandoola A, and
Mark C. Siracusa,
May
Artis D.
IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multi-potent progenitor
type 2 (MPPtype2) cells.
Journal of Experimental Medicine. 2013 Aug 26; 210(9): 1823-37. (PMID 23960191)
• Noti M, Tait Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR,
Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, MenardKatcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal
Malefyt R, Sleiman PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, and Artis D.
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.
Nature Medicine. 2013 Aug; 19(8); 1005-13. (PMID: 23872715)
• Kim BS, Siracusa MC, Saenz SA, Noti M, Monticelli LA, Sonnenberg GF, Hepworth MR, Van
Voorhees AS, Comeau MR, and Artis D.
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.
Science Translational Medicine. 2013 Jan 30; 5(170):170ra16. (PMID: 23363980) • Giacomin PR , Siracusa MC, Walsh KP, Grencis RK, Kubo M, Comeau MR, and Artis D.
Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal
helminth infection.
Journal of Immunology. 2012 Nov 1; 189(9):4371-8. (PMID: 23024277)
• Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, LaRosa DF, Renner
ED, Orange JS, Bushman FD, and Artis D.
Commensal bacterial-derived signals limit innate immune mechanisms of allergen-induced TH2 cell
development.
Nature Medicine. 2012 Mar 25; 18(4):538-46. (PMID: 22447074)
• Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel
LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegel SF, Comeau MR, and Artis
D.
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Nature. 2011 Aug 14; 477(7363):229-33. (PMID: 21841801)
• Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban Jr. JF, Tocker JE, Budelsky AL, Kleinschek
MA, Kastelein RA, Kambayashi T, Bhandoola A, and Artis D.
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses.
Nature. 2010 Nov; 31(11):407-13. (PMID: 20200520)
• Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y,
Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, and Artis D.
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent
immunity.
Nature Immunology. 2009 Jul; 10(7):697-705. (PMID: 19465906)
• Siracusa MC, Reece JJ, Urban Jr. JF, and Scott AL.
Dynamics of Alveolar Macrophage Activation in Response to Helminth Infection.
Journal of Leukocyte Biology. 2008 Dec; 84(6):1422-33. (PMID: 18719016)
• Reece JJ, Siracusa MC, Southard TL, Brayton CF, Urban Jr. JF, and Scott AL.
Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung.
Infection and Immunity. 2008 Aug; 76(8):3511-24. (PMID: 18505812)
• Siracusa MC, Overstreet MG, Housseau F, Scott AL, and Klein SL.
17β-Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells.
Mark C. Siracusa,
May
The Journal of Immunology. 2008 Feb 1; 180(3):1423-1431. (PMID: 18209037)
• Berg M, Gambhira R, Siracusa MC, Hoiczyk E, Roden R, and Ketner G.
HPV16 L1 capsid protein expressed from viable adenovirus recombinants elicit
neutralizing antibody in mice.
Vaccine. 2007 Apr 30; 25(17):3501-10. (PMID: 16914239)
• Reece JJ, Siracusa MC, and Scott AL.
Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar
Macrophages.
Infection and Immunity. 2006 Sept; 74(9):4970-81. (PMID: 16926388)
• Foote LC, Cifuni JM, Siracusa MC, Monteforte GM, McCole JL, D’Orazio CC, Hastings WD, and
Rothstein TL.
Interleukin-4 produces a breakdown of tolerance in vivo with autoantibody formation and tissue damage. Autoimmunity. 2004 Dec; 37(8):569-77. (PMID: 15763919)
REVIEW JOURNALS
• Siracusa MC, Kim BS, and Artis D.
Basophils and allergic inflammation.
Journal of Allergy and Clinical Immunology. 2013 Oct; 132(4):789-801. (PMID: 24075190)
• Siracusa MC, Tait Wojno ED, and Artis D.
Functional heterogeneity in the basophil cell lineage.
Advances in Immunology. 2012; 115:141-59. (PMID: 22608258)
• Siracusa MC, Comeau MR, and Artis D.
New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation.
Annals of the NY Academy of Sciences. 2011 Jan; 1217:166-77. (PMID: 21276006)
• Siracusa MC and Artis D.
Basophil Functions During Type 2 Inflammation: Initiators, Regulators and Effectors.
The Open Allergy Journal. 2010; 3:46-51.
• Siracusa MC, Perrigoue JG, Comeau MR, and Artis D.
New paradigms in basophil development, regulation and function.
Immunology and Cell Biology. 2010 Mar-Apr; 88(3):275-84. (PMID: 20125116)
INVITED BOOK CHAPTERS
• Siracusa MC and Artis D.
Basophils, mast cells and eosinophils.
Principles in Immunology. (Eds. Smith PD, MacDonald TT, Blumber RS). London: Garland Science.
2012.
PRESENTATIONS
• Siracusa MC, Tait Wojno ED, Osborne LC, Saenz SA, Kim BS, Benitez AJ, Ruymann KR, Farber DL,
Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR and Artis D. TSLPmediated extramedullary hematopoiesis promotes allergic inflammation. May 2014 • The American
Association of Immunologists Annual Meeting. (selected oral presentation)
• Siracusa MC, Tait Wojno ED, Osborne LC, Saenz SA, Kim BS, Benitez AJ, Ruymann KR, Farber DL,
Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR and Artis D. TSLPmediated extramedullary hematopoiesis promotes allergic inflammation. Oct. 2013 • Cytokines 2013:
Mark C. Siracusa,
May
From Molecular Mechanisms to Human Disease.
• Siracusa MC, Tait Wojno ED, Osborne LC, Saenz SA, Kim BS, Benitez AJ, Ruymann KR, Farber DL,
Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR and Artis D. mediated extramedullary hematopoiesis promotes allergic inflammation. May 2013 • The American
Association of Immunologists Annual Meeting. (selected oral presentation)
• Siracusa MC, Tait Wojno ED, Osborne LC, Saenz SA, Kim BS, Benitez AJ, Ruymann KR, Farber DL,
Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR and Artis D. TSLPmediated extramedullary hematopoiesis promotes immunity to helminth parasites. April 2013 • Annual
Woods Hole Immunoparasitology Meeting. (selected oral presentation)
• Siracusa MC, Saenz SA, Headley MB, Ziegler SF, and Artis D.
TSLP-elicits IL-3-independent basophil hematopoiesis and type 2 inflammation. July 2011 • International
Congress of Mucosal Immunology. (selected oral presentation)
• Siracusa MC, Saenz SA, Headley MB, Ziegler SF, and Artis, D.
Epithelial cell-derived TSLP influences granulocyte development and function in the periphery. June
2010 • Keystone Symposia-Innate Immunity Mechanisms Linking with Adaptive Immunity.
• Siracusa MC, Craig JM, Urban Jr. JF, Pearce EJ, Artis D, and Scott AL.
STAT6-independent alternative activation of the pulmonary environment in response to helminth
infection. March 2010 • Annual Woods Hole Immunoparasitology Meeting. (selected oral presentation)
• Siracusa MC, Craig JM, Urban Jr. JF, Pearce EJ, Artis D, and Scott AL.
STAT6-independent alternative activation of the pulmonary environment in response to helminth
infection. July 2009 • The American Association of Immunologists Annual Meeting. (selected oral
presentation)
• Siracusa MC, Overstreet MG, Scott AL, and Klein SL.
int
Estrogens augment the number and activity of CD11c+CD49b+NK1.1 cells in vivo. May 2007 • The
American Association of Immunologists Annual Meeting.
• Siracusa MC, Reece JJ, and Scott AL.
Helminth Infection Induces a Persistent Changes in Lung DC Populations. December 2005 • American
Association of Tropical Medicine and Hygiene Annual Meeting.
• Siracusa MC, Reece JJ, and Scott AL.
Helminth Infection Induces a Pulmonary Environment that Dampens Allergen-Induced Hyperreactivity.
December 2005 • American Association of Tropical Medicine and Hygiene Annual Meeting. (selected
oral presentation)
AWARDS
• AAI Trainee Abstract Award (2014)
• Rutgers Biomedical and Health Sciences (RBHS) Chancellor Scholar (2014)
• K22 Career Transition Award (2014)
• AAI Trainee Abstract Award (2013)
• Ruth L. Kirschstein National Service Award (2010)
• Institutional T32 Training Grant AI007417 (2006)
• Golden Apple Teaching Assistant Nominee (2005)
• The Hegner, Cort Root Honorary Fellowship (2004)
• Sigma Xi Research Society Induction (2000)
Mark C. Siracusa,
May
RESEARCH SUPPORT
• Current
NIH K22 Career Transition Award
Interrogating innate immunity to helminth parasites
awarded 1/9/2014
• Past
NIH F32 fellowship
Dissecting innate immunity to Helminth parasites
3/5/2010 - 3/4/2013
Hegner-Cort-Root Fellowship
NIH T32 training grant AI007417
2004
2006-2008
12 calendar
$151,947