(2002 ZCGJYGB) 'K 'CGI ,141 LZM
F B G V Z F
SYKZG\
QJZSG FRGH\ KVSG\ ,FRGH\ KPZGD
,FKZB QC QZT ,NYRZV F[P
FVKI ,KCZTPF NKNDFG FVKI HGIP ,\KNNM \GBKZC K\GZK[ ,QGKRMJF ,JZGVVZ FBGVZN FJNGYVF ,FIV[PF \BGVZN 'IPF ,\K\ZGSPG FPKN[P FBGVZN 'IKF
KM BXPR ,E[F QJZS \GNGIC FERYC TXGC[ ZIB ZYIPC
ZYKTC ,FPKN[PF FBGVZF OGI\C GTKK\SF OK[RFP 62%
,OKRKPJKGG OKNZRKP 49.6%) BVZP KIPXCG OKNZRKPC ,OKRKPJKGGC
.|4~ (YGZK F\ 17.3%-G BVZP KIPX 24.6%
[GN[C OKNVGJP CZYC NBZ[KC FRGZIBN FTXGC[ FZKYSC
OKYGNF OKNVGJPFP 51.2% KM BXPR ,FKDGNGYRGBN \GBVZKP
OGI\P OKRG[ OKTXPBC GTKK\SF GNB \GBVZKPC QJZSF \NIPC
10%-C FBXPR OKRKPJKG-FDP N[ FNKJRFG ,FPKN[PF FBGVZF
.|5~ OKZIB FRGH\ KVSG\ \NKJR FRKGX BN .OKNVGJPFP
Z\GKG Z\GK \NCGYPG FXGVR \MVGF FRGH\ KVSG\ \MKZX
OKZXG\ ,OKNZRKP ,OKRKPJKG OKNNGM FRGH\F KVSG\ .KCZTPF ONGTC
-K\CG \IYZP-K\CN OGKM SRMRF NM .OKZIB OKZK[M\G OKKIPX
.GNB OKZK[M\C OKSGPTF OKVEPFP ONT\FN NGMK GRKB TCJ
OKZMPRF OKRG[ FRGH\ KVSG\ 20,000-P FNTPN OKPKKY C"FZBC
.O[ZKP BNN
GH FRKEPC FRGH\ KVSG\ N[ \GZKMPF GTKDF 1998 \R[C
50%=35% KM BKF FMZTFFG ,ZNGE EZBKNKP 14-M N[ Y\T OGMSN
NBZ[KC .|7,6~ FRGH\ KVSG\ OKMZGX C"FZBC FKKSGNMGBF NNMP
,FRGH\ KVSG\ N[ FMKZXF ZGTK[ NT OKYKGEP OKRG\R GPSZGV BN
QF \IYZPF-K\C \G\[ZP KP[Z BN QVGBC GNCY\F[ \GMZTF LB
ZG[KBC .OKRG[ FRGH\ KVSG\ OKMZGX FKKSGNMGBFP LZTN 20% KM
KVSG\M GB QGHPM OKRKGXP OF \GKG[ZF KEK-NT GNB OKZXGPN Q\KRF
\GRGM\ GNB OKZK[M\N SIKKN Z[VBP GRKB FH ZG[KB ONGB .FRGH\
FRGH\ KVSG\N NGEDF [GYKCF OZGD OKZYPF \KCZPC .KGVKZ N[
OKZXG\N \GKBGVZ \GKZGF \SIKKPF ,\CIZR FNGPT\ \XVFN GNB
KV-NT GIMGF BN GB GYECR BN O\GNKTKG O\GIKJC ,O\GMKB[
OKZXGPFP YNIN OK\TN .|8~ OKZMGPG OKZEDGP OKKBGVZ OKEEP
\KGG\C OKRKGXP ORKB[ OKNKTZ OKZPGI UBG KBGGN-KVSG\ OKVSGP
FRKB \KGG\F KCD-NT \RKGXPF FNGM\F[ GB |10,9~ FNGM\F
\BH OT .|12,11~ NKTVF ZPGIF N[ \YKGEPF FNGM\F \B \VY[P
\GKZIB N[ \PKGSP FEKP OKBZP OKRZXKFP YNI KM ,QKKXN [K
\GMKB \ZYCN OKZXG\F \B KBPXT QVGBC OZKCTFC \KZGCKX
LMC QKB ONGB .(
) \KREVY
.ZXGPF N[ G\GMKBN Z[BC ZG[KB
GMP ± Good Manufacturing Practice
N N MC \C I Z R F M B K F F RG H\ F K V S G\ \M K Z X Z [B M
QJZSF \NIPC OKYGNF OKCZ OKNVGJP[ BNV QKB ,FKKSGNMGBF
GNB FRGH\ KVSG\ \MKZX N[ FVYKFG ,GNB OKTXPBC OD OKZHTR
FKKSGNMGBF NNMC Z[BP Z\GK \CIZR OK\TN BKF QJZS KNGIC
.|7 ,6 ,4=1~
893
N[ CZ ZVSP FNTP FRGH\ KVSG\ N[ \CIZR FM FMKZX
OKKY OBF .QJZS KNGI KEK-NT GNB OKVSG\ \MKZXN TDGRC \GNB[
KVSG\G FRGH\ KPZGD N[ \GIKJCCG \GNKTKC LPG\F YXGP TEKP
OKVSG\ \MKZXN \GTP[P \TEGR OBF ?QJZS KNGIC NGVKJM FRGH\
Z K X Y \
QJ Z SF
K NGIP
\K XIP
, O K KR M E T
O K ZY I P
K B X P KP
KV - N T
OGI\C ZYKTC ,ONGVKJC OKVSGR OKTXPB CN[KPC OKRKRGTP
OKIKM[F OKTXPBF EIB OF FRGH\ KVSG\ .FPKN[PF FBGVZF
NC GY P F
N G V KJ N
FPN[FM
QJ Z SF
K NG I
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.FNIPC
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KCDN
\GCZ
F NK J R F
\GNB[
LZ E
KFPG
F N TP
,GNB
GNB
FRGH\
OKZXG\
N[
KVSG\
\NKJR
O\GIKJCG
O\GNKTK
KVSG\ CN[KP KCDN \GNB[ \GNTGP FH ZPBPC .FPKB\PF
\GKGET
\BCF
LG\
,QJZSF
KNGIC
NGVKJF
OT
GNB
FRGH\
.YGZK F\G OKRDGZJSBGJKV NT \GKRG[BZ \GKTEP
.FH B[GRC KTEP TEKP BKCFN BKF GH FZKYSC FZJPF
G\GTXPBC Q\KR OK\TN ONGB ,ON[GP GRKB FH TEKP ORPGB
ZYKTC ,QJZSF \NIPC OKYGNF OKNVGJPN NM[GP WGTKK \\N
FRGH\ KVSG\ CN[N OK[YCPG FNKTV \GRKKRT\F OKTKCPF GNB
ZV[N NGMK FHM[ NM[GP WGTKK .O\NIPC USGR KNGVKJ KTXPBM
-K\NC FTV[F TGRPNG ,BSKD-EIP G\GNKTKG NGVKJF \GMKB \B
,OKB\P GRKB[ KNGVKJ CN[KP \GCYTC OZDKFN FNGNTF FKGXZ
ZGVK[N SKSC \GGFN NGMK FH WGTKK ,LMP FZ\K .BSKD-LEKBP
.FNGI-BVGZ \ZG[Y\F
QJZSG FRGH\ KVSG\ ,FRGH\ KPZGD
T
KNGIP ZMKR YNI ,OKKRMET OKZYIPC GNCY\F[ OKRG\R KV-N
NGVKJN NKCYPC \GVSGR NGVKJ \GKGZ[VB OK[VIP QJZSF
OKTXPBC \GHMZ\P \GVSGRF NGVKJF \GKGZ[VB .|5=1~ NCGYPF
OKNNGM GNB OKTXPB .'FPKN[P FBGVZ' OTF KVC KGZYF OGI\FP
OKKTEP OKRG\R NT OKSSGCP ORKB O\KCZP[ ,OKRG[ OKNGVKJ QGGDP
KBPXT QVGBC \K[TR GNB NGVKJ KTXPBC \GTKK\SFF .OKYXGP
.OKRG[ OKNVJPG OKBVGZ KEK-NT GB OPXT OKNVGJPF KEK-NT
.GNB OKPKN[P OKNGVKJP ECMR YNI FGGFP FRGH\ KVSG\ \NKJR
QJZSC OKYGNF OKNVGJP GC GNNMRG C"FZBC TXGC[ ZYIPC
) \[MZMF
FRGH\ KVSG\ GNJR 55%-M[ BXPR ,(
TXGPPC OKZK[M\ 2.6 LZX NVGJP NM .OKNZRKPG OKRKPJKG GNNM[
KM ZC\SF ,E[F QJZSC ZCTC GNI[ OK[R N[ FZKYSC .|1~
FZKYSC .|2~ OKRG[ FRGH\ KVSG\ Q\NIP LNFPC GNJR QFP 80.9%
FZKBPP FNIPC GYN[ \GNVGJPFP 56% KM FNT |3~ \ZIB
,FPKN[PF FBGVZF OGI\P OKTXPBC GTKK\SF QKPF-KMZEC
.FRGH\ KVSG\ GMZX 20% OMG\PG
colon cancer
nutritional supplements; dietary supplements; cancer; complementary medicine; alternative medicine; intergrative medicine.
Key words:
(2002 ZCGJYGB) 'K 'CGI ,141 LZM
-\NKEI ZIBN OK[RC OKRDGZJSBGJKVF \GPZ KMZT \YKECC
\GMGPR GNB OKZPGI \GPZ KM ZZC\F ,E[F QJZSC \GYGNF IZGB
ZYIPC .|19~ IZGB-\NKEI ZIBN \GBKZC OK[R \PGTN ZMKR QVGBC
-JSBGJKV N[ FFGCD FMKZX KM ,ODEGF |20~ FKNZJSGBC TXGC[
.E[F QJZSC \GYNN QGMKSF \B K\GTP[P QVGBC F\KIVF OKRDGZ
N[ \GKCZ\ GIYNR OFC[ |21~ OKK\ECTP OKZYIPC ,LMN USGRC
N[ \CMTP FTV[F FPDEGF ,OEB ZGYPP E[ QJZS KB\
.20%=18% N[ ZGTK[C QJZSF KB\ \GCZ\F NT OKRDGZJSBGJKVF
QJZSC OKYGNF OKZCDN Z[YFC OD GBXPR OKPGE OKBXPKP
OKK\BKSB OKZCD KM ,FNT \GKDGNGKPEKVB \GKGETP ;\KRGPZTF
OKZCD \PGTN \KRGPZTF QJZS N[ Z\GK FMGPR \GIKM[C OKYGN
,\GKDGNGKPEKVBF \GKVX\F ECNP ONGB .|22~ CZTPF \GRKEPP
-BGJKV \MKZXC NY QGZ\K ODEGP OKK\GCZT\F OKZYIP ZVSPC
OKNGIC NGVKJN GB \KRGPZTF QJZS N[ TRP \ZJPN OKRDGZJS
\K\GTP[P FEKZK F\VXKR OKZCMT NT OKZYIPC .GH \GZKBPPC
\ZK\T FRGH\C GRGHKR OKZCMTF[M \KRGPZTF QJZS \TVGFC
-JSBGJKV \VSG\ KM ,BXPR |24~ KRKNY ZYIPC .OKRDGZJSBGJKV
QJZS KNGI N[ FXGCYN (Q\[V KTZH) OKRRDKN DGSP OKRDGZ
KB\ N[ \GCZ\FF OGXPKXN FPZD ,IG\KRN FR\PF \TC \KRGPZTF
KB\ N[ (
) \RMG\PF KB\F \GGPF \ZCDFNG QJZSF
.\B[F
apoptosis
[K OKRDGZJSBGJKV \VSG\N[ LMN \GKGET \GPKKY ,FPGEC
.(
) \[MZMF QJZSC OKNGI NT FCKJKP FTV[F
[K OKRGCNVGHKBN FVK[IN KM BXPR ,|25~ FECTPC TXGC[ ZYIPC
GZCT[ KTP \PYKZ N[ N\KVB KB\ \GCZ\F NT \CMTP FTV[F
OKB\C \RMG\P KB\ \GGPN KGZKD OT ,(
) FZP\F
.GNB
colon cancer
transformation
FTV[FN \GKGET \GPKKY ,\G\B[F NT FTV[F ECNP
ONGB .FPGRBNP KNGIC NGVKJM OKRDGZJSBGJKV N[ FCKJKPF
OFN GYZHGF[ |26~ OKZCMTC ZYIPN \GSIKK\PG \GJTGP \GKGETF
OKZCMTC \GZGZDF \GIKM[ KM ,BXPR FH ZYIPC .FPGRBNP KB\
\K\GTP[P FMGPR F\KKF OKRDGZJSBGJKV-\ZK\T FRGH\ GNCKY[
.FZYCF \XGCYC FPDEGF[ GHP
-BGJKV \MKZXC OKMPG\F OKHPZ NT \GTKCXP GNB \GKGET
KRGKR[ TRPCG FKKSGNMGBF NNMC FNIPF N[ KRG[BZ TRPC GNB
?E[F QJZSN OKKNGDS OKRD \GB[GRF OK[RC QGDM ,QGMKS \GXGCYC
,FKDZGZKM) QJZSC EIF NGVKJF CN[C FRGH\ KVSG\ Q\P OBF
FPNIFF KKGMKS \B ZV[N KG[T (FKVZ\GKEZ GB FKDGNGYRGB
KRG[KN[ TRPN Z[YFC FTV[F OKVSG\N \TEGR OBF ?NGVKJFG
OBF ?FNIPF \GR[KFN QGMKSF \RJYF O[N QJZSF \NIP N[
Q G D M , N G V KJ F K T X P B \ G N K T K \ B O K Z V [ P F R G H \ F KV S G \
,LGP\N OGYP [K OBF ?G\GB OKRKJYP GB ,\GRZYFG FKVZ\GPKM
FNTP NVGJPF[M FRGH\ KVSG\ \MKZXP ONT\FN GB EDR\FN
-QKC \GCGD\N OZGD GRKBG NKTZ GRKB[ USG\C NGVKJN \GZ[VB
?\GK\VGZ\
SYKZG\
QFN[ FRCKPC \GPGEF \GCGMZ\ OF GNB OKZPGI . |16 ~
QF ,F[NI \KRDGZJSB \GNKTV GNB \GCGMZ\N .NGKEZJSBN
(Q\[V KTZHC ZYKTC) OKRRDKN \GNNGMG KIPX ZGYPP \GYVGP
.(FKGSC OKBXPR ZYKTC) QKHEKBEG QKJSKRD QGDM ,OKRGCNVGHKBG
QVGBC OKRDGZJSBGJKVC FZK[T FRGH\F \GK\BKSB OK[R CZYC
ONGTC OK[R \PGTN (OGKC OKRGCNVGHKB D"P 200-M) K\GTP[P
D"P 10=5-M) OKRDGZJSBGJKVC EGBP FNE Q\RGH\[ ,KCZTPF
ZGTK[ KM ,ODEGF \GKDGNGKPEKVB \GKVX\C .(OGKC OKRGCNVGHKB
10=4 KV LGPR \GK\BKSB OK[R CZYC OIZFG E[F QJZSP F\GP\F
\GIV QVKC E[F QJZS ,QM-NT-Z\K .|17~ \GKBYKZPB OK[R \PGTN
FNIP N[ Z\GK FMGPR \GIKM[C QKKVB\PG NNM LZEC ZKBPP
.FKNDRBG FYKZPB-QGVXC OK[RN FBGG[FC \GZGZD \IN[PF
FYKZPB-QGVXN \GZDFP \GKRVK OK[R[M KM ,FECGTF \RKKRTP
\MNGFG FNED ,OKRDGZJSBGJKVC FNE FRGH\N Q\RGH\ \B \GR[PG
OK[RC \IGGEPF FPZN FGG\[P BKF[ ET ,E[F QJZS \GIKM[
.|18~ \GKBYKZPBF
F B G V Z F
\GNB[ \KCZPN \GCG[\F ,\KBGVZF \GZVSF \ZKYS LG\P
\GKRKNY \GJNIFN YVSP FRTP \GR\GR QRKBG \GZGZC QRKB GNB
\GECGT NT \MP\SPF FBGVZ N[ KIMGRF QEKTC ZYKTC ,\GSSCGP
)
ZDBPC ,\BHC QKGXPF \GZPN .(
L[PFC GZMHGK) OKKRKNY OKHPZ OKPKKY ZK[TF \KBGVZF \GZVSF
FJNIFC NGYK[ \GGFN OKPKGSP OKZYPC OKKG[T[ ,(ZPBPF
.EKIKF NVGJPF N[ \KRKNYF
evidence based medicine
,\GKTEP \GECGTG OKZYIP NT SSC\FN QGXZF \GZPN ONGB
OD FRGH\ KVSG\ \MKZXN \TEGRF \GTP[PF \B QGICN KGBZ
FJKN[N KTXPB GH FMKZXC OKBGZF OKNVGJPF N[ O\GBZ \EGYRP
-\GMKB \B ZV[N O\RGPBN KG[T[ USGR KTXPBG O\GBKZC NT
.|13~ OFKKI
OKNVGJPFP ZMKR YNI[ FECGTF BGF GH FKDGSC CG[I JCKF
KVSG\ \MKZX NT FJNIFC NVJPF BVGZF \B OKV\[P ORKB
B[GRC JTGP TEKP OKBVGZN KM OKRKPBP O\KCZP .|14,3~ FRGH\
O\KCZP .GNB OKVSG\ \MKZX NT WTKKN OKRKRGTP ORKB[ GB FH
OKRG[F FRGH\F KVSG\ NT Z\GK EGPNN OKBVGZFP OKVXP
FXT \NCYN OFKNB \GRVN GNMGK[ LM ,O\NIPN OKPKB\PF
OKVSGB ,FH FGGYP FNGTV-UG\K[N ET .|13~ FNGTV-UG\K[G
,OKZMPP \GXT :\GZGYP ZVSPP [YGCPF TEKPF \B OKNVGJPF
OKRG\KT ,OKRGIZK ,\KTGXYP FRKB[ \GZVS ,FIV[P-KCGZYG OKRM[
TCJF KZGEPG TCJF \GKGRIC OKZMGP KEK-NT Q\KRF TEKPG ,OKKPGK
.|15~ OKKI-QMSP UBG QPKFP GRKB FH TEKP OK\TN .\IYZPF-K\CC
LM ,ZYGCPF TEKPFG OKRG\RF UGSKBN LZGXF FNGT LM LG\P
KCDN NM[GP WGTKK GN \\NG NVGJPF OT FNGTV U\[N Q\KR[
\GGFN NGMK FHM[ NM[GP WGTKK .ZIB GB FH FRGH\ USG\ \NKJR
TRPC NVGJPF \PXTF LG\ ,FNGI-BVGZ \ZG[Y\F ZGVK[N SKSC
QJY YNI QGICN FSRR FH ZPBP \ZDSPC .QJZSF \NIPC NGVKJG
KR[C EYP\R .FH B[GRC \PKKYF FVRTF \KBGVZF \GZVSF LG\P
O\GB OKMZGXF ,OKNVGJPF KEK-NT CIZR QVGBC OKMZXRF OKVSG\
FBGVZC OKRG[ OKNVJP \XNPF \GCYTC GB KBPXT QVGBC
YZ BNB ,B[GRC TGEKF NM \B UKYFN GR\RGGMC QKB .FPKN[PF
.FKVZDGKNCKCN O\GRVFNG OKBZGYF QKKRT \B ZZGTN
OKRDGZJSBGJKV
Z[YFC ZYKTC ,OKRDGZJSBGJKVC FCZ \GRKKRT\F \PKKY FRGZIBN
\ZMHGP UB \GZGYPFP YNICG ,IZGB-\NKEI NKDC OK[RC NGVKJN
QJZSF \NIP \B TGRPN FZJPC GNB \GCGMZ\ \MKZXN \GSIKK\F
894
(2002 ZCGJYGB) 'K 'CGI ,141 LZM
F B G V Z F
SYKZG\
(CGZKYC) QGHPC OKRDGZJSBGJKV \NGM\
:1
F N C J
D"P 15 { (Y"PS 200 SGM) FKGS CNI
D"P 15 { (FKGS IPY 'D 15) FKGS ZK[M\
D"P 15 { (\KVM) OKRGIJ Q\[V KTZH
D"P 10 { ('D 50) \TNE KRKTZD
D"P 15 { ('D 50) GVGJ
.
.
.
.
OKKDGNGKPEKVB OKZYIPP QF FH F\ NT \GKTEPF \GKGETF ZYKT
.OKKI-KNTC NT OKZYIPPG
F\N[ LM NT \GHPZP OKKDGNGKPEKVBF OKZYIPF \GBXG\
OKZYIP N[ CZ ZVSPCG ,|33~ QJZS-\GEDGR \GRGM\ [K YGZKF
\GYNN QGMKSF \B \KIVP F\F KM BXPR OKKI-KNTCC GTXGC[
IKM[FG ,OKEKBGRGCNV N[ CZ ZVSP KGXP YGZKF F\C .QJZSC
GNB OKZPGI .(
)
-F BGF OFKRKCP
OYNIG ,QJZS-\EDGR \GNKTV OFN OKSIKKPF [KG ,QGXPKI-KEDGR OF
.\KJGKCKJRB \GNKTV KNTCG \YNE-KEDGR OF GNB OKZPGI N[
, E [ F Q J Z S E DR Z Y KT C B K F Q J Z S F \ E DG R \ G N K T VF
\GNIPG FCKYF ,\GBKZF ,ZGTF ,CNCNF ,\[MZMF ,\KRGPZTF
F Z[ P
-F KM BXPR OKZYIP ZVSPC .\GVSGR \GZKBPP
QM-GPM .OKRKY\F OKB\F NT TKV[K[ KNCP ,\RMG\P KB\ \GGP
O\GGF\FN KRGKIF OKHRB { FHBRKYGZGB CMTP FH ZPGI[ BXPR
OKB\ N[ O\GCZ\FN FCG[IF ,SKHRDGKDRB QMG ,QJZS KB\ N[
.|34,29~ OKKRJZS
OKZYGIF OKSIKK\P |35~ FRGZIBN GPSZGV[ OKZYIP KR[C
,K\ECTPF ,QG[BZF ZYIPC .E[F QJZS NT YGZKF F\F \TV[FN
\GIKM[ F\KKF YGZK F\C OKZ[TGP OKP G\[[ OKZCMTC KM BXPR
\K\GTP[P FMGPR QFN[ \GZKBPPF \DZEG QNEGD ,E[F \G\B[
OKZCMTC \G\B[F ,QM-NT-Z\K .ECNC OKP G\[[ OKZCMT \PGTN
GKFG Z\GK ZIGBP CN[C GI\V\F YGZK F\C OKCZGTP OKP G\[[
.QKKVGBC \GPKNB \GIV
GYECR ,QVKC CGZKYC OKR[ Z[T L[PR[ |36~ KRKNY ZYIPC
F\IVF FPDEGF ZYIPC .E[C \B[F \\KZMN IG\KR GZCT[ OK[R
GMZX[ OK[RC IG\KRF ZIBN E[C \GZKBPPF \GR[KF \GIKM[C
F\KKF \B[F \GR[KF ZGTK[ \\IVF .OGKC YGZK F\ \GSGM 3 NTP
.FNIPF N[ K\NI\F CN[C OK[RC YZ \PKKY
,\GZK[K \GKGET QRKB YGZK F\ \MKZXC \GMPG\F \GKGETF
NT TGEK BN[ ZIBP .OKKDGNGKPEKVB OKZYIPP ZYKTC \GTCGRG
J Z V Y G Z K F \ \M K Z X \G C Y T C \ GK \ G T P [P K BG GN - \ GT V [F
F\ \MKZXN \VZGD \GEDR\FC LZGX QKB ,FRK[C \GNY \GTZVFN
.ONGVKJ LNFPC FH KTXPB CN[N OKRKRGTPF OKNVGJP CZYC YGZK
OKNJGRF OKNVGJPC YGZK F\ \MKZXC \GZKFH \[ZER ,\BH OT
,QKEPGY GB QKZKVSB GPM ,F[KZYF QGRDRP NT \GTKV[PF \GVGZ\
NT ZGSBN [K FPGE FCKSP .Q\GNKTV \B ZKCDFN G\KKJR CYT
GB \GKJRD F[KZY \GKTCC OKYGNF OKNVGJPN YGZK F\ \MKZX
WNPGP ,LMP FZ\K .IG\KR ZGCTN OKEPGTF OKNVGJPC QMG ,\G[MZR
BN[ ZIBP ,YGZK F\ \MKZXP TRPKFN \GYKRKP GB \GZF OK[RN
.|29~ FH FY[P N[ G\GIKJC KCDN IGGJ-KMGZB OKZYIP GTXGC
N[ TRPC GB NGVKJC YGZKF F\F CGNK[N OGYP [K QMB OB
YGZK F\ CN[N OGYP [K OB FNB[F FNGT ,OKRG[F QJZSF KDGS
GB FKVZ\GPKMF \GNKTK \B ZV[K FH NGVKJ OBF ?FKVZ\GPKMC
epigallocatechin gallate EGCG
EGCG
895
.
ZGTK[ \\IVFNG \KRGPZTFG E[F QJZS \TKRPN FRGH\C OKRDGZJS
\MKZXC \GZKFHN OKRTGJF [K ONGB .GNB \GNIPP F\GP\F
\GCZ\F NT |27~ OKIGGKE N[ OXPGXP ZVSP CYT ,GNB \GCGMZ\
L[PC Q\RGH\C FKGSF \MKZX \B GNTF[ OK[RC E[F N\KVB KB\
.OKKTGC[
N[ Z[YFC |28 ~ FRGZIBN OSZGV[ FZKYS ZPBPC
\GBXG\ QMG FH K\KKTC B[GR ZMHGP ,E[F QJZSG OKRDGZJSBGJKV
-GE FTV[F [K OKRDGZJSBGJKVN[ LM NT \GTKCXPF OKZYIP
) \KCN[
\GPZC OKR\KRF OKRDGZJSBGJKV .(
QJNGY OGKYC \KR\GPF OKB\ \GCZ\FN OKPZGD \GKDGNGKSKV
NGKEZJSB OT CN[KPC FH QGRKPC OKRDGZJSBGJKV Q\P .QDGZJSB
.OKB\F \GCZ\F N[ NY K\GZI\ CGMKTN OZGD \GKDGNGKSKV \GPZC
\GPZFP LZTN 10 KV) \GKDGNGYPZBV \GPZC ,QM-NT-Z\K
N[ K\GTP[P CGMKTN OKRDGZJSBGJKV OKPZGD (\GKDGNGKSKVF
QM-GPM .QDGZJSBF QJNGY OGKYN Z[Y BNN ,\KB\F \GCZ\FF
QVKSYGPJ N[ CN[KP KM ,|28~ ZPBP G\GBC ZMHGP
K\GZI\ CGMKTN OGZDN KG[T (QKJSKRD ZYKTC) OKRDGZJSBGJKVG
.OKB\F \GCZ\F NT QVKSYGPJF N[ \CMTPF FTV[FF \TKRPNG
OZGD QKJSKRD N[ EGBP OKFGCD OKRGRKP Q\P FH CXPC OD ,\BH OT
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