QING-LI WU
Department of Plant Biology and Pathology
Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901
E-Mail: qlwu@aesop.rutgers.edu
Telephone: 848-932-6238
Fax: (732) 932-9441
EDUCATION:
1994-1997 Ph.D. in natural products chemistry and chemotaxonomy, Peking
Union Medical College and Chinese Academy of Medical Sciences, China, 1997
1991- 1994 M.S. in pharmacognosy, Peking Union Medical College and Chinese
Academy of Medical Sciences, Beijing, China, 1994
1985 - 1989 B.S. in pharmacy, Anhui College of Traditional Chinese Medicine,
Hefei, China, 1989
PROFESSIONAL EXPERIENCE:
2005-present, Assistant Research Professor, New Use Agriculture & Natural
Plant Products Program and Department of Plant Biology and Pathology,
Rutgers University
2001-2005, Research Associate, Department of Plant Sciences, Rutgers
University.
1999-2001, Postdoctoral Fellow in Department of Psychiatry, Harvard Medical
School.
1997-1999, Assistant professor, Institute of Medicinal Plant Development, Peking
Union Medical College and Chinese Academy of Medical Sciences, China
MAJOR AREA OF EXPERTISE:
My area of expertise is in plant-based medicines and nutraceuticals, with
specialization in natural product chemistry including bioactive compound
isolation, structure determination, analytical method development and validation
(HPLC & LC/MS), bio-directed fractionation, standardization and quality control of
botanicals, and plant genetic resources and plant taxonomy. With specialization
in polyphenols chemistry and the PK study, my research focuses on the
application and chemistry of natural compounds in traditional medicine and
expands to nutrition and food sciences related to public health in the
treatment/prevention of age-related diseases.
AWARDS AND HONORs:
2010-current: Editorial board member of American Journal of Analytical
Chemistry.
2009-Research Team Award from Rutgers, SEBS and the NJAES for or the
Research Team Award in the SEBS for the Research Project: Partnership for
Sustainable Economic Growth in Africa Through Natural Plant Products
(PFID/NP). Team Member.
2005-current: Visiting professor of Key Laboratory, Institute of Medicinal Plant
Development (IMPLAD), Chinese Academy of Medical Sciences.
State Administration of Traditional Chinese Medicine (SATCM), Awarded Silver
Prize for Master‘s Thesis: Species Systematization and Quality Evaluation of
Common used Traditional Chinese Drugs (12/1995).
AFFILIATION
Sino-American Pharmaceutical Professionals Association (SAPA)
American Chemical Society (ACS)
TEACHING AND TRAINING RESPONSIBILITY
Graduate Involvement:
Member, Graduate Faculty in Medicinal Chemistry, School of Pharmacy, Rutgers
Current Graduate Students at Rutgers in this academic year
MS Students:
2011-current Adolfo Pertuz, MS candidate, Plant Biology and Pathology, SEBS
2011-current Kelsey Gustafson, MS candidate, Medicinal Chemistry, School of
Pharmacy
2012-current Daniel Giurleod, MS Candidate, Medicinal Chemisty, School of
Pharmacy
PhD Students:
2010-current Derek Hawkins, Ph. D. candidate, Medicinal Chemistry, School of
Pharmacy
2011-current Thomas Villani, Ph.D. candidate, Medicinal Chemisty, School of
Pharmacy
Member of Graduate Students Committee and/or Co-Advisor Those Received
Their Degrees:
2010. Yanping Xu, MS., Medicinal Chemistry, School of Pharmacy, Completion,
December, 2010.
Thesis: Identification of Polyphenols and Quantification of Anthocyanidins
in Grapes and Grape-derived Products.
2009. Cara Welch, Ph.D., Medicinal Chemistry, School of Pharmacy, Completion,
December, 2009.
Dissertation: Chemistry and Pharmacology of Kinkéliba (Combretum
micranthum), a West African Medicinal Plant.
2008. Diandian Shen, Ph.D., Medicinal Chemistry, School of Pharmacy,
Completion, August, 2008.
Dissertation: Development of anti-inflammatory agents from the aromatic
plants, Origanum spp. and Mentha spp., and analytical methods on the
quality control of bioactive phenolic compounds.
2008. Julia Coppin, MS., Medicinal Chemistry, School of Pharmacy, Completion,
April, 2008.
Thesis: Nutritional And Medicinal Values Of Moringa oleifera Leaves From
Sub-Saharan Africa: Ghana, Rwanda, Senegal And Zambia.
Provided training and service to other undergraduate and graduate students,
visiting scientists and post doctoral researchers in natural products chemistry. A
selected list of recent undergraduate students follow from 2011 (average
mentoring 2 undergraduates in hands-on research each year)
2012: Mark Sterlin, undergraduate student, SEBS
2012: Lisa Giordan, undergraduate student, SEBS
2011: Tham Peng Wai, undergraduate student, chemistry and Biochemistry
2011: Jasminder Singh, undergraduate student, chemistry and Biochemistry
2011: Fenxiao Liu, undergraduate student, chemistry and Biochemistry
Current Teaching Activity in Undergraduate Education:
Medicinal Plants, Plant Science 11:776:312, Fall Semester since 2005 to current.
Instructors: J.E. Simon and Q.L. Wu. Wu has about 40% responsibility for this
course. 3 Credits, upper division undergraduate course.
Plants and Human Health, Senior level undergraduate colloquia: Plant Science
11:015:408. Spring Semester since 2006 to current. Instructors: J.E. Simon and
Q.L. Wu. Wu has about 60% responsibility for this course. 3 Credits, upper
division undergraduate colloquia.
Plants Biology and Pathology, Spring Semester, with contributing lab practicum
for B.R. Huang, undergraduate course. Wu assists in the training of
undergraduate students in using HPLC, and natural products chemistry,
extraction, analysis and botanical standardization.
Plant Physiology, Spring Semester, with contributing lab practicum for Y Xu,
Ramapo College, undergraduate course. Wu assists in the training of
undergraduate students in using HPLC, and natural products chemistry.
Guest Lecturer, Wu has provided guest lectures in Plant Science’s EthnoBotany
and in MedChem, Herbal Medicines and Nutraceuticals which is a senior and MS
level course in MedChem and School of Pharmacy largely for pharmacy
students.
GRANTS
Federal Competitive Grants:
Current:
2012-2015. Alternative Utilization of Roselle Hibiscus as Small Farm and Niche
Market Crop. USDA/NIFA-2012-38821-20092. Total Budget of Rutgers part:
$50,000. Our role from Rutgers is in the phytochemical profiling, search for new
bioactives and natural products and some value added product development. Wu
as the Co-PI in Rutgers provides the leadership on chemistry investigation.
2012-2017. People, Rules and Organizations Supporting the Protection of
Ecosystem Resources (PROSPER) Program in support of the USAID-Liberia.
Wu serves as investigator. Total budget: $21.5 millions and Rutgers part is: $1.1
million). Rutgers will undertake work in Liberia for ARD, Inc. In particular, Rutgers
will collaborate with PROSPER partners ACDI/VOCA, Action for Greater Harvest
(AGRHA) and Agribusiness in Sustainable Natural African Plant Products
(ASNAPP) to conduct livelihood activities related to non-timber forest products;
and to support the development of educational curriculum and capacity building
in the forestry sector of Liberia. Wu’s role will be to lead the natural products
analyses and lab quality control procedures to aid in the commercialization
efforts overseas of Liberian medicinals, spices and botanicals.
2012-2013. A New Capacity to Advance Aquaculture Through Growout
Technology, Natural Product Development, and Science-based Management of
Coastal Restoration Efforts. USDA. Wu and Simon involved as leading the
chemical characterization of the algae and marine organisms. Most of funds are
earmarked for needed equipment for the production, processing of marine algae.
$97,000.
2012-2015. Sustainable African Indigenous Vegetable (AIV) Production and
Market-Chain Development for Improved Health and Nutrition and Income
Generation by Smallholder Farmers in Kenya, Tanzania and Zambia. HortCRSP
from USAID-Washington. Wu serves as an investigator, leading work on
nutritional composition and phytochemical analysis of the AIVs for health and
nutrition. $979,856.
2011-2014. Sustainable African Indigenous Vegetable Production and MarketChain Development for Improved Health and Nutrition and Income Generation by
Smallholder Farmers in Kenya, Tanzania and Zambia. USAID. 10/01/201109/29/2014. $980,000 (Purdue prime lead, Rutgers co-leading this initiative).
USAID-International Horticultural CRSP initiative (from UC-Davis).
Our research seeks to support and strengthen the African Indigenous Vegetables
(AIVs) industry using a market-first approach to overcoming constraints along the
value chain leading to improved production practices, supply, postharvest
handling, distribution and consumer acceptability of AIVs in Kenya, Tanzania and
Zambia. Key ingredients are development of a strong public: private sector
partnership that ensures activities support needs of consumers and markets and
involve germplasm evaluation, development of sustainable production and seed
production/saving techniques, improved market access and building capacity of
stakeholders through outreach programs at all levels of the AIV value chain. This
project will both characterize nutritional attributes of AIVs as well as create
awareness of health and nutritional benefits of AIVs through household and
market surveys and educational programs about nutrition. We will bridge
information gaps through research and promotional activities cooperating with
private sector, farmer groups, government, research and NGO communities to
build confidence in AIV production and enhancement of farmer adoption of AIV
systems. Our activities will build capacity of African universities and institutions
involved in research and training of extension personnel who serve the farm
community. Improved AIVs will provide nutritional complements to diets. The
approach is tailored to local dietary needs and promotes biodiversity and sound
environmental management in production while providing affordable edible foods
that can be grown and consumed locally or processed. Activities will result in
improved income generation, new microenterprises across the value chain,
improved availability of nutritious AIVs for consumption and overall improved
quality of life. Wu, Q-L. (Co-PI).
2011-2012. Inventory and rapid throughput screening of indigenous utilized plant
species for development of new natural products Indigenous Natural Products.
MCA-Namibia Innovation Fund. Total funding: $230,000. Wu, QL. Investigator.
Project Period: 03/15/2011-03/14/2012.
The proposed action aims at surveying and inventorying the utilized indigenous
Namibian flora for the purpose of identifying potentially new uses as ingredients
for indigenous Namibian natural products in foods, flavours, health, nutrition,
cosmetic products for local sustainable economic development. Plant species
identified as suitable for consideration in terms of use will be further investigated
and subjected to Screens-to-Nature (STN) technology whereby we introduce 11
portable, field-deployable pharmacological screens, with all training associated in
its use into Namibia for screening in-country. Screens-to-Nature, guided by the
“Reversing the Flow” principle brings simple pharmacological screens to
developing countries. This approach does not remove any natural resources from
partnering countries. Instead, it trains and equips local scientists, students,
communities, others locally with innovative, cost-effective, and portable
nutraceutical, nutritional and drug-discovery tools. Further evaluation criteria
include chemical profiling, regional and international market assessments,
sustainability (wild-crafting vs. cultivation) and feasibility of creating a product
development value chain benefitting Namibia PPOs. This work will lead to a
shortlist of 10-20 candidate species for product development using a sciencebased market strategies and public: private sector partnerships.
2007-2012. Complementary and Alternative Medicine (CERC) for Alzheimer’s
disease With an Emphasis on grape derived polyphenol. National Institute of
Health (NIH). Prime Award No. 1 PO1 AT004511-01. 09/30/07-09/29/2012.
As a key team member in the Bioanalytical and Bioavailability Core of this
national research program led by the New York Mt. Sinai Medical Center, in
concert with Purdue University, and the Albert Einstein School of Medicine,
Rutgers provides the leadership in: (1) characterizing and screening the raw
materials used in this CERC project, for the polyphenols in the grape samples
(grape fruit, grape seed, grape extracts, grape juice, grape fractions); (2) provide
assistance to Purdue in chemical analysis of the grape metabolites in human
plasma; and (3) archiving and authentication of the raw materials from grape and
wine and providing quality control oversight and guidelines for the botanical
products. (WU, QL serves as co-PI at Rutgers). Rutgers research as
subcontract with Purdue University from Mt. Sinai. $372,625.
2011-2012. Standardize and Develop a Sickle Cell Disease Drug for Phase II
Clinical Trials. National Institute of Health (NIH). NIH-SBIR grant collaborated
with Cosimid Inc. Project Period: 09/01/2011-8/30/2012. To support the clinic
study of COS-130 (phase II), the NUANPP at Rutgers University has the leading
role in (1) developing a chemical fingerprint of the original botanical materials
using LC/MS, (2) elucidating the anti-sickling compound(s) to use as markers of
activity, (3) to develop quality control program for standardization of COS-103,
and (4) in growing authenticated plant material which provides the main
ingredients of COS-103 under controlled conditions. (WU, QL serves as co-PI at
Rutgers). $57,777.
Finished
2008-2011. Chin, K.L. High Value Specialty and Ethnic Medicinal Crops for the
Fresh and Processing Produce and Nutraceutical Industries. USDA SCRI grant
to Southern University. Cooperators: Wu (co-PI) at Rutgers have subcontract for
the chemistry work within this project. $137,500.00. As the co-PI in this project,
Wu provided leadership in plant sampling and chemical analysis and the
development of analytical protocols for foliar (leaf) and floral (calyx)
phytochemical analyses.
2005-2011. National Botanical Center for Age-Related Diseases (with Purdue
University and University of Alabama as the lead institutions). NIH-OD-00-04.
Project Period: 04/15/2005-9/30/2011. Research focus was on botanical
authentication, chemical analyses and natural product characterization and
standardization for botanicals and extracts used in the research cores of this
national botanical center. Our Rutgers unit led the Botanical and Educational
core of this center. We identify new and alternative plant sources for specific
polyphenols, characterize new anti-inflammatory and provide the leadership in
the botanical authentication using botanical taxonomic, molecular and chemical
approaches, and technical support and advice on products, plant species, and
botanical standardization. Simon, J.E. (PI) and Wu, Q-L. (Co-PI).
2009. Wu, Q.L. (PI) and Simon, J.E. (Co-PI) et al. Pilot grant of $25,000.00 from
NIH sponsored Pennington Botanical Center: Phytochemical Investigation on the
African Herbal Tea Kinkéliba (Combretum micranthum) with Focus on its Impact
on Metabolic Disorders.
2006-2009. Team member in Partnership in Food Industry Development for
Natural Products (PFID/NP), a 5-year global USAID-sponsored research and
development program where core and satellite countries were all in sub-Sahara
Africa. Wu’s leadership is in development of standards and chemical
characteriziation of new and traditional African medicinal plant products (Griffonia,
Voacanga, Kombo); flavorings, spices and herbal teas (Grains of Paradise,
hibiscus, paprika and chilis) anti-malarials (Artemisia annua) and nutritional
dietary supplements to improve human nutrition (Moringa). Wu leads the
analytical core of this team. The impact of the griffonia and vocanga work on
establishing standards were used by the government of Ghana in the
establishment of their national standards and currently it is our understanding
that a request has been made by Ghana to turn these into ISO standards.
2005.-2007. Moudgil, K (PI). Modulation of Autoimmunity by Green tea
Polyphenols. National Institute of Health SBIR Phase II Grant to University of
Maryland. Cooperators: Simon, J.E. (PI) and Q.L. Wu (co-PI) at Rutgers have
subcontract for the chemistry and botanical standardization work within this
project. Subcontract between Univ. of Maryland and Rutgers. $82,516.00.
2002. Wu, Q.L. and Simon, J.E. et al. Pilot grant of $10,000.00 from NIH
sponsored Purdue-UAB Botanical Center for purchasing laboratory equipment.
2001-2005. Botanical Center and Age-Related Diseases founded by NIH (OD00-004, Amount: $8 million, Period: 01/01/00-12/31/05). The Center focused the
diverse basic research and educational strengths on characterization the active
ingredients in botanical with the emphasis on polyphenolics and determine their
efficiency in reducing risk of age-related diseases including osteoporosis, cancer,
cardiovascular disease, and neurodegeneration. As a member of Botanical Core,
my responsibilities were to provide the leadership in plant identification, plant
sample sourcing and processing, and providing quality control and method
development for biological ingredients in the plant samples used in the Botanical
Center. (Wu as co-PI in Rutgers).
2006. USAID and Foundation grants to support research in anti-malarials
(Artemisia annua) and nutritional dietary supplements to improve human nutrition
(Moringa oliefera).
External Industry and/or NGO Grants:
2010. Noventis Company. Provided leadership in obtaining a donation of an
excellent LC/MS system including a Triple Quadrupole MicroMass Ultima,
Waters HPLC and operation software, approximately value of $500,000.00 and
led to install the instrument in 2010. (Wu served as PI and core contact that led
to the procurement of this instrument)
2003-current. As a service for fee, test the authenticity and botanical quality of a
wide range of botanicals and herbals from raw plant material through finished
product including assisting in the quality control (QC) research and service for
Herbalist and Alchemist, Inc., Clinton, N.J. $18,000. (Wu serves as PI and Simon
serves as co-PI).
2008, Xechem, Inc. Support of Natural Products Chemistry and Product
Standardization. $35,000. (J.E. Simon and Q.L. Wu)
2008. Sleepy Hollow Farms. Provided leadership in quality control in goldenseal
for alkaloids. $1,450. 00. (Wu and Simon, co-PIs)
2008. A.M. Todd Company. Provided leadership in quality control for 5-HTP
products. $1,000.00. (Wu and Simon, co-PIs)
2008. Response Products. Participated to developed processing method for
Enrichment of CMO from Kombo Butter. $17,000.00. (Simon and Wu, co-PIs)
2008. Wenbin Den’s Lab, Department of Cell Biology and Human Anatomy, UC
Davis. Provided leadership in collaboration on quality control on natural products
for biological study and obtain donation of various supplies of value $6,000.00.
2007, Xechem, Inc. Participated to obtain donation of various laboratory
instruments of value $210,450.00.
2007, Response Products, Inc. Provided leadership in method development for
enriching CMO from kombo butter, $25,000.00
2007. Herbalist and Alchemist, Inc. Provided leadership in quality control (QC)
research and service, $18,000.
2007, Provid, Inc. Provided leadership in chemical analysis based upon
utilization of the HPLC/UV/MS System, $5,000.00.
2006. Herbalist and Alchemist, Inc. Provided leadership in quality control (QC)
research and service, $18,000.
2006. Covance Company. Provided leadership in obtaining a donation of an
excellent TRIPLE QUAD MS instrument, approximately value of $400,000 and
led to install the instrument.
2004. New Jersey Soy Council. Participated to help analysis of soy isoflavones in
different soy varieties collected from New Jersey farm, $3,500.
2004-2005. Sleepy Hollow Farms. USDA-SBIR Phase II. Provided leadership in
quality control in goldenseal for alkaloids. $25,000.
Internal Rutgers Support:
2011-2012. Developing a natural products nutraceutical industry using algae, sea
kelp and marine organims. Funded by the Marine Institute and the New Jersey
Agricultural Expertiment Station. Valued at $55,000/year including funds for
graduate research assistanship plus $10,000 for supplies. Wu serves as the PI.
PROFESSIONAL ACTIVITIES AND SERVICES
2011-current: Editorial board member of Pharmaceutical Crops.
2010-current: Editorial board member of American Journal of Analytical
Chemistry.
2010-current: Editorial board member of Journal of Analytical Methods in
Chemistry.
Reviewer for: J. Chromatogrphy A; J. Chromatogrphy B; J. Agric. Food Chem.;
Talanta; Journal of Pharmaceutical and Biomedical Analysis; Rapid
Communication on Mass Spectmetry; Natural Products Communications. J.
Separation Sciences.
PUBLICATION LIST
Published Scientific Journal Articles (*=graduate student involvement):
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2012. Ho, L., M. G. Ferruzzi, E.M. Janle, J.Wang, B. Gong, T.Y. Chen, J.
Lobo, B. Cooper, Q. L. Wu, S.T. Talcott, S.S. Percival, J.E. Simon and
G.M. Pasinetti Identification of brain-targeted bioactive dietary Quercetin-3O-Glucuronide as a novel intervention for Alzheimer’s Disease. FASEB. J.
(accepted and in press).
Yanping Xu*, James. E. Simon, Mario G. Ferruzzi, Lap Ho, Guilio M.
Passinetti, and Qingli Wu (2012), Quantification of anthocyanidins in the
grapes and grape juice products with acid assisted hydrolysis using LC/MS.
Journal of Functional Food. 4: 710-717.
Yanping Xu*, James. E. Simon, Cara Welch*, JoLynne D. Wightman, Mario
G. Ferruzzi, Lap Ho, Guilio M. Passinetti, and Qingli Wu (2011), Survey of
Poplyphenol Constituents in the Grapes and Grape derived Products, Journal
of Agricultural and Food chemistry. 59 (19):10586–10593.
Qing-Li Wu, Yong-Hong Yang and James E. Simon (2011). Chemical
profiling and quantification of isoflavones in kudzu by LC/UV/MS. American
J. Anal. Chem., 2 (6): 665-674.
Diandian Shen*, Min-Hsiung Pan, Qing-Li Wu, Chung-Heon Park, H.
Rodolfo Juliani, Chi-Tang Ho, and James E. Simon (2011). A Rapid
LC/MS/MS Method for the Analysis of Nonvolatile Antiinflammatory Agents
from Mentha spp. Journal of Food Science 76 (6):900-908.
Shen*, D., Q.L. Wu, W.J. Sciarappa and J.E. Simon (2011).
Chromatographic fingerprints and quantitative analysis of isoflavones in
Tofu-type soybeans. J. Food Chemistry.130 (4):1003-1009.
Andrej Jedinak, Shailesh Dudhgaonkar, Qing-li Wu, Jim Simon and Daniel
Sliva (2011). Anti-inflammatory activity of edible oyster mushroom is
mediated through the inhibition of NF-kB and AP-1 signaling. BMC Nutrition
Journal 10, 52-61
Shen* D, Pan MH, Wu QL, Park CH, Juliani HR, Ho CT, Simon JE. (2010)
LC-MS method for the simultaneous quantitation of the anti-inflammatory
constituents in oregano (Origanum species). J Agric Food Chem.
23;58(12):7119-25.
9. Jonathan G Mun, Michael D Grannan, Pamela J Lachcik, Randy B Rogers,
Gad G Yousef, Mary H Grace, Elsa M Janle, Qing Li Wu, James E Simon,
Connie M Weaver and Mary Ann Lila (2010). Tracking deposition of a 14Cradiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone.
Experimental Biology and Medicine. 235 (10), 1224-1235.
10. Vingtdeux, V., H. Zhao, P. Chandakkar, Q.L. Wu, J. E. Simon, E. M. Janle,
J. Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud (2010). MPK
signaling activation by resveratrol modulates amyloid-beta peptide
metabolism. The Journal of Biological chemistry, 19;285(12) 9100-13.
11. Li L, Tu YH, Xu LJ, Ma P, Peng Y. Wu QL and Xiao PG. (2009):
Detemination of polyphenols and antioxidant activities of Ehretia thyrsiflora.
Natural Products Research and Development, 21, 360.
12. Mario G. Ferruzzi, Jessica K. Lobo, Elsa Janle, Bruce Cooper, James E.
Simon, Qing-Li Wu, Cara Welch, Lap Ho, Connie Weaver and Giulio M.
Pasinetti (2009). Bioavailability of catechins and gallic acid from grape seed
extract is improved by repeated dosing in rats. Journal of Alzheimer
Disease 18:113.
13. H. Rodolfo Juliani, Cara R. Welch*, Qing-Li Wu, Babou Diouf, Diatta
Malainy, James E. Simon (2008). Chemistry and quality of hibiscus
(Hibiscus sabdariffa) for developing the natural product industry in Senegal,
Journal of Food Science 74: S113.
14. Min-Hui Li,Jian-Min Chen, Yong Peng, Qingli Wu, Pei-Gen Xiao (2008).
Investigation of Danshen and related medicinal plants in China. Journal of
Ethnopharmacology 120:419
15. H.R. Kim, R. Rajaiah, Q.L. Wu, S.R. Satpute, J.E. Simon, B.M. Berman and
K.D. Moudgil (2008). Modulation of autoimmune arthritis by polyphenols of
green tea (Camellia sinensis) involves the suppression of pro-inflammatory
IL-17 and the induction of immunoregulatory IL-10 cytokine response.
Journal of Nutrition, 138(11):2111-2116.
16. Cara Welch*, Qing-Li Wu and James E. Simon (2007). Recent Advances
on Anthocyanin Analysis and Characterization. Current Analytical
Chemistry, 4: 75-101. (Wu was invited as senior author).
17. Cheng, K.W., Q.L. Wu, J.E. Simon, F. Chen and M. Wang (2007). Inhibitory
Effect of Fruit Extract on the Formation of Heterocyclic Amines. J.
Agricultural and Food Chemistry, 55(25):10359-65.
18. Qing-Li Wu, Yong-Hong Yang and James E. Simon (2007). Determination
of Proanthocyanidins in Areca Nuts by High-performance Liquid
Chromatography Combined with Mass Spectrometry, Chemistry and
Biodiversity, 4, 2817.
19. Wang, M., K.W. Cheng, Qing-Li Wu and J.E. Simon (2007). Quantification
of nepatalactones in catnip (Nepeta cateria L.) by HPLC coupled with
ultraviolet and mass spectrometric detection. Phytochemical Analysis. 18
(2): 157-160.
20. Diandian Shen*, Qing-Li Wu, Ming-Fu Wang, Yong-Hong Yang, Edmond
Lavoie J. and James E. Simon (2006), Quantification of the Predominant
Catechins in Leaves of Acacia Catechu by LC/ESI-MS. Journal of Food and
Agricultural Chemistry, 54: 3219-3224.
21. Zhongze Ma, Qing-Li Wu, David Y. W. Lee, Micheal Tracy and Scott E.
Lukas. (2005): Determination of puerarin in human plasma by high
performance liquid chromatography. Journal of chromatography B, 823:
108-114.
22. Mingfu Wang, ChungHeon Park, Qing-Li Wu, and James E. Simon. (2005):
Analysis of Artemisin in Artemisia annua L. by LC-MS with selected Ion
monitoring. Journal of Food and Agricultural Chemistry, 53: 7010-7013.
23. Qing-Li Wu, Mingfu Wang and James E. Simon. (2005): Liquid
chromatographic/mass spectrometric determination of proanthocyanidins in
fresh grape and grape products. Rapid Communications in Mass
Spectrometry, 19: 2062-2068.
24. Qing-Li Wu, Mingfu Wang and James E. Simon. (2004): Analytical methods
to determine phytoestrogenic compounds. Journal of chromatography B,
812: 325-355 (Wu was invited as senior author).
25. Qing-Li Wu, Mingfu Wang, William J. Sciarappa and James E. Simon.
(2004): LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu
soybeans. Journal of Agricultural and Food Chemistry, 52: 2763-2769.
26. Qing-Li Wu, Mingfu Wang and James E. Simon. (2003): Determination of
isoflavones in red clover and related species by high-performance liquid
chromatography combined with ultraviolet and mass spectrometric
detection. Journal of chromatography A, 1016: 195-209.
27. Mingfu Wang, Yaakov Tadmor, Qing-Li Wu, Chee-Kok Chin, Stephen A.
Garrison and James E. Simon (2003). Quantification of protodioscin and
rutin in asparagus shoots by LC/MS and HPLC Methods, Journal of
Agricultural and Food Chemistry, 51: 6132-6136.
28. Qing-Li Wu, Mingfu Wang and James E. Simon. (2003): Determination of
Proanthacyanidins in Grape Products by Liquid Chromatography/Mass
Spectrometric Detection under Low Collision Energy, Analytical Chemistry,
75: 2440-2444.
29. David E. Zaurov, James E. Simon, Chungheon Park, Wudeneh Letchamo,
Qing-Li Wu, Ming-Fu Wang, Igor V. Belolipov and Ishenbay Sodombekov.
(2002): Medicinal plants from central and western Asia, Korean J. Medicinal
Crop Sci. 10: 277-283.
30. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999): Flavonoid
Glycosides from Thalictrum przewalskii. Journal of Asian Natural Products
Research, 1: 301-306.
31. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999):
Constituents from from Thalictrum smithii. Zhong Cao Yao, 30 (5): 321-323.
32. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999): New
Triterpene Glycosides from Thalictrum smithii. Chinese Chemical Letters,
10 (6): 485-486.
33. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1998): New
Flavonoid Glycosides from Thalictrum przewalskii. Chinese Chemical
Letters, 10 (4): 295-296.
34. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-Shan Yang and Pei-gen Xiao.
Constituents of Hyperricum, (1998): Phytotherapy Research, 12, S164-S168.
35. Qing-Li Wu, Sheng-ping Wang, Jun-Shan Yang and Pei-gen Xiao.
Flavonoids from Hyperricum henry, (1998): Natural Products Research and
Development, 10 (4): 15-18.
36. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-shan Yang and Pei-gen Xiao.
(1998): Xanthones from Hyperricum japonicum and H. henryi.
Phytochemistry, 49(5): 1395-1402.
37. Qing-Li Wu, Sheng-ping Wang, Yong-hong Liao, Li-jun Du, Jun-shan Yang
and Pei-gen Xiao. (1998): New Phloroglucinol Glycosides from Hypericum
japonicum. Chinese Chemical Letters, 9 (5): 469-470.
38. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-Shan Yang and Pei-gen
Xiao. (1998): Chromone Glycosides and Flavonols from Hypericum
japonicum Thunb. exe Murray. Phytochemistry, 49(5), 1417-1420.
39. Qing-Li Wu, Yong-Hong Liao, Sheng-ping Wang, Li-Wei Wang, Yu-Xiu
Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1997): New
Prenylatedflavonol from Hypericum japonicum. Chinese Chemical Letters,
8(4): 317-318.
40. Qing-Li Wu, Sheng-ping Wang, Guang-zhong Tu, Jun-Shan Yang and YuXiu Feng. (1997): Alkaloids from Piper puberulum. Phytochemistry, 44(4):
727-730.
41. Qing-Li Wu, Yong-Hong Liao, Sheng-Ping Wang, Li-Wei Wang, Yu-Xiu
Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1997): New
Chromone Glycosides from Hypericum japonicum. Chinese Chemical
Letters, 8(1): 41-42.
42. Qing-Li Wu, Yong-Hong Liao, Sheng-Ping Wang, Li-Wei Wang, Yu-Xiu
Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1996): Novel
Pyrones from Hypericum japonicum. Chinese Chemical Letters, 7(11):
1011-1012.
43. Qing-Li Wu, Sheng-Ping Wang, Jun-Shan Yang and Yu-Xiu Feng.
Chemical Study on Piper (Piperaceae). (1998): Natural Products Research
and Development, (Review). 10(2): 84-89.
44. Qing-Li Wu, Sheng-ping Wang, Jun-Shan Yang and Pei-Gen Xiao. (1998):
Pharmacological Study on Hypericum (Clusiaceae). Zhong Cao Yao, (a
review). 29, supplement 135-137.
45. Qing-Li Wu, Sheng-Ping Wang, Yong-Hong Liao, Li-Wei Wang, Yu-Xiu
Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1996): New
Constituents from Hypericum japonicum. Chinese Chemical Letters, 7(12):
1095-1096.
46. Qing-Li Wu, Jun-Shan Yang and Yu-Xiu Feng. (1994): Two New Alkaloids
from Piper puberulum. Chinese Chemical Letters, 5 (3): 203-206.
47. Qing-Li Wu and Yu-Xiu Feng. (1994): Comparative Study on Constituents
of Essential Oil from Traditional Chinese Drugs Haifenteng Attributed to
Piper. Natural Products Research and Development, 6 (3): 9-16.
48. Qing-Li Wu and Yu-Xiu Feng. Lignans from Piper Genus (Piperaceae) and
their Bioactivity. 1994. World Notes on Plant Medicine. (Review). 9 (2): 5156
49. Zhu-hua Wu, Chuan-Fu Cheng and Qing-Li Wu. (1991): Pharmacognostic
study of “Xin-Yi” (Magnolia) in Anhui. China Journal of Chinese Materia
Medica. 16: 13-17.
Scientific Papers- Submitted to Journals and under formal review or under
internal review prior to submission (copies of papers available and asterisks
indicate *graduate student):
50. 2012. Nichols, D.B., K.R. Gurukumar, B. Amartya, Q.L. Wu, J.C. Lee, N.
Sakamoto, J.E. Simon and N. Kaushik-Basu. Anti-Hepatitis C Virus NS5B
Polymerase Activity of Hibiscus Calyces Extract. (submitted and under
review)
51. 2012. Welch, C., E. Bassenne, I. Raskin, J.E. Simon and Q.L. Wu.
Kinkeliba: (Combretum microcanthum): Phytochemical composition,
bioguided separation and antidiabetic activity. J. Agriculure and Food
Chemistry (submitted and under review).
52. 2012. Coppin, J.P., Y. Xu, H. Chen, H.R. Juliani, Q.L. Wu and J.E. Simon.
Determination of Flavonoids in Moringa oleifera by LC/MS (ready for
submission).
53. 2012. Coppin, J.P., Y. Xu, H. Chen, H.R. Juliani, Q.L. Wu and J.E. Simon.
Determination of Polyphenols and Lipid Soluble Vitamins in
Moringa
oleifera (ready for submission).
Patents:
54. 2012. Neerja Kaushik-Basu, Qing-Li Wu and James E. Simon.
IDENTIFICATION OF NATURAL PLANT EXTRACTS HARBORING ANTIHEPATITIS C VIRUS NS5B POLYMERASE ACTIVITY. Total 26 pages.
Office of Corporate Liaison and Technology Transfer, Attorney Docket
Number: RWJ 11-120. Provisional patent filed by UMDNJ in concert with
OTC, Rutgers University, New Brunswick.
55. 2009. Wu, Qing-Li, Wenbin Deng and James E. Simon. Office of Corporate
Liaison and Technology Transfer, Rutgers University Docket Number. 09041 Uses of African Plant Extract and Derived Compounds as Novel
Neuroprotective Agents. 37 pages. Provisional patent filed by Rutgers OTC,
Rutgers University, New Brunswick.
56. 2010. Wu, Qing-Li, Cara Welch and James E. Simon. Office of Corporate
Liaison and Technology Transfer, Attorney Docket Number:
70439.00459/RU10-087. Novel Type Alkaloids as anti-diabetic Agents and
Their Preparation from African Herb Tea. Provisional patent filed by
Rutgers OTC, Rutgers University, New Brunswick.
57. 2010. Shen, Diandian, Wu, Qing-Li and James E. Simon. Office of
Corporate Liaison and Technology Transfer, Attorney Docket Number:
70439.00461/09-038. OREGANO AND MINT ANTI-INFLAMMATORY
COMPOSITIONS AND METHODS CROSS REFERENCE TO RELATED
APPLICATIONS. Provisional patent being filed by Rutgers OTC, Rutgers
University, New Brunswick.
Scientific Reviews and Original Papers published in Scientific Books and
Proceedings as Chapters:
58. 2012. Tom Villani, H. Rodolfo Juliani, James E. Simon, Qingli Wu. Hibiscus
sabdariffa: Phytochemistry, Quality Control and Health Properties. In 2012,
Juliani H.R., J.E. Simon and C.T. Ho (eds). African
American Chemical Society ACS Symposium
Washington, D.C. USA (accepted).
59. 2012. Kelsey Gustafson, Qing-Li Wu, and James
angolensis: Bioactive Compounds and Medicinal
Natural Plant Products.
Series, ACS Press,
E. Simon. Pycnanthus
Applications. In 2012,
Juliani H.R., J.E. Simon and C.T. Ho (eds). African Natural Plant Products.
American Chemical Society ACS Symposium Series, ACS Press,
Washington, D.C. USA (accepted).
60. 2009. Swami Nathan, Prema Tripathy, Qingli Wu and Faith C. Belanger.
Nicosan: A Phytomedicinal Treament for Sickle Cell Disease. In 2009, Juliani
H.R., J.E. Simon and C.T. Ho (eds). African Natural Plant Products: New
Discoveries and Challenges in Chemistry and Quality. American Chemical
Society ACS Symposium Series of Herbs, ACS Press, Washington, D.C.
USA. pp 263-276.
61. 2009. Kwan Su Kim, H. Rodolfo Juliani, Michael Bucuk, Dan Acquaye, Julie
Asante-Dartey, Qingli Wu, and James E Simon. Quality Control and 5-HTP
(5-Hydroxy-L-tryptophan) Analysis of Griffonia (Griffonia simplicifolia (DC.)
Baill.) Seed Accessions Collected in Ghana. In 2009, Juliani H.R., J.E.
Simon and C.T. Ho (eds). African Natural Plant Products: New Discoveries
and Challenges in Chemistry and Quality. American Chemical Society ACS
Symposium Series of Herbs, ACS Press, Washington, D.C. USA. pp 381-
390.
62. 2008. Liang Zhou, Qing-Li Wu, James E. Simon, Chun-Yu Liu, Jun-Shan
Yang, Yong-Hong Lia. Phytochemistry and Quality Control of Black Cohosh,
other Medicinal Cimicifuga species and Their Derived Products, pp. 59-99.
In: 2008. Ho, C.T., J.E. Simon, F. Shahidi and Y. Shao (eds). Dietary
Supplements. American Chemical Society Symposium Series 987. American
Chemical Society, Washington, D.C. USA. Pp. 59-99
63. 2007. William J. Sciarappa, Laura K. Hunsberger, Diandian Shen, Qing-Li
Wu, Jim Simon, and Brian Hulme. Evaluation of Edamame Cultivars in New
Jersey and MArryland, New Crops and New Uses, Editor by J. Janick and A
Whipkey, Published by ASHS Pres. Pp.223-227.
64. 2007. Chung-Heon Park, Pirre Tannous, H. Rodolfo Juliani, Qing-Li Wu,
William J. Sciarappa, Rick Van Vranken, Peter Nitzsche, Dennis Dalponte,
and Jim Simon. Catnip as Source of Essential Oils, New Crops and New
Uses, Editor by J. Janick and A Whipkey, Published by ASHS Pres. Pp. 311315.
65. 2006. Mingfu Wang, Chia-pei Liang, Qing-Li Wu, James E. Simon and ChiTang Ho. Instrumental Analysis of Popular Botanical Products in the US
MArket, ACS Symposium Series of Herbs: Challenges in Chemistry and
Biology, Editor by Mingfu Wang, Shengming Sang, Chi-Tang Ho, Published
by ACS. pp. 39-54.
66. 2005. Mingfu Wang, Yi Jin, Qing-Li Wu, James E. Simon and Chi-Tang Ho.
Chemistry, Pharmacology and quality control of selected popular oriental
herbs in the US market in Asian Functional Foods, CRC Press, 2005.
67. 2003. Qing-Li Wu, Mingfu Wang, James E. Simon Shi-Chun Yu, Pei-Gen
Xiao and Chi-Tang Ho. Studies on the chemical Constituents of Loquat
Leaves (Eriobotrya japonica), ACS Symposium Series of Oriental Herbs,
Editor by Chi-Tang Ho, Published by ACS. pp. 292-306.
68. 2002. Qing-Li Wu and Yu-Xiu Feng. Haifengteng (Kiper kadsura) in Species
Systematization and Quality Evaluation of Commonly used Chinese
Traditional Drugs, Volume IV, People Health Press, Beijing, China. Pp. 455522
69. 2002. Mingfu Wang, Qing-Li Wu, Yaakov Tadmor, James E. Simon,
Sengmin Sang and Chi-Tang Ho. Schisandra chinensis: Chemistry and
Analysis, ACS Symposium Series of Oriental Herbs, Editor by Chi-Tang Ho,
Published by ACS. pp. 234-245.
Presentation on National and International Conferences and Invited Oral
Presentation:
70. 2012. Tom Villani, Qingli Wu and James E. Simon. Preliminary Survey of
Bioactive Natural Products from Algae Species Cultured at NJAIC Relevant to
Human Health and Nutrition. Open House in New Jersey Aquaculture
Innovation CenterAt Rutgers University. 3920 BAYSHORE AVENUE. North
Cape May, New Jersey 08204, September 27, 2012.
71. Kelsey Gustafson, Daniel Giurleo, Chi-Tang Ho, Wenbin Dang, Min-Hsiung
Pan, Qingli Wu, James E. Simon. ANTIOXIDANT, ANTI-INFLAMMATORY
AND NEUROPROTECTIVE ACTIVITIES OF PLASTOQUINONES FROM
THE SEED FAT OF PYCNANTHUS ANGOLENSIS. 2012 International
Congress on Natural Products Research. New York, New York, USA 10017.
July 28-August 1, 2012.
72. Daniel Giurleo, Kelsey Gustafson, Jafar Chaudry, Jasminder Singh, Thomas
Villani, Albert Ayeni, Tom Orton, Ed Dager, Robert Pyne, Chung Park, Qingli
Wu, James Simon. Chemical diversity of Capsinoids and Polyphenols in
Capsicum spp. 245th ACS National Meeting & Exposition, Philadelphia,
Pennsylvania, August 19-23, 2012.
73. Villani, T., A. Pertuz, R. Fatto, J.E. Simon and Q.L. Wu. CHEMICAL
SURVEY OF COMMERCIAL GRAPE SEED DERIVED PRODUCTS. 245th
ACS National Meeting & Exposition, Philadelphia, Pennsylvania, August 1923, 2012.
74. Tom Villani, Tham Peng Wei, Qingli Wu and James E. Simon. Analysis of
Polyphenols in Green and Purple Basil. Flavor, Fragrances & Perception
Symposium .Rutgers, Busch Campus, Piscataway, NJ 08854, April 23, 2012.
75. Kelsey Gustafson, Daniel Giurleo, Chi-Tang Ho, Wenbin Dang, Qingli Wu,
James E. Simon. Novel substituted fatty acids from the seed fat of
Pycnanthus angolensis with antioxidant and anti-inflammatory properties.
Flavor, Fragrances & Perception Symposium .Rutgers, Busch Campus,
Piscataway, NJ 08854, April 23, 2012.
76. 2011. Tom Villani, Kelsey Gustafson, Mario G. Ferruzzi, Elsa Janle, Lap Ho,
Giulio M. Pasinetti, Qingli Wu, James E. Simon. Determination of
polyphenols in grape derived superfood and characterization of the newly
collected GSE samples by LC/UV/MS. Presented at the 4th Annual Meeting
Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New
York, NY, October 6-7, 2011.
77. 2011. Lap Ho, Mario G. Ferruzzi, Elsa Janle, TY Chen, Cooper B, Talcott S,
James E. Simon, Qingli Wu, Wang J, Giulio M. Pasinetti, Development of
brain-targeting grape derived polyphenolics for Alzheimer’s disease
prevention and therapy. 5th International Conferences on Polyphenols and
Health, Barcelona, Spain, October 17-20, 2011.
78. Tzu-Ying Chen, Jessica K. Lobo, Connie Weaver, James E. Simon, Qingli
Wu, Stephen Talcott, Giulio M. Pasinetti, Lap Ho, Mario G. Ferruzzi & Elsa
M. Janle, Bioavailability and Brain Distribution of Anthocyanin and
Quercetin Metabolites from Grape Juice and Wine, Experimental biology,
Washington DC, April 9-13, 2011.
79. Yangping Xu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti,
Qing-Li Wu and James E. Simon. Identification of Anthocyanidins in grape
derived products by HPLC/UV/MSD. Presented at the 3rd Annual Meeting
Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. The
Samuel Roberts Noble Foundation, Ardmore, OK, September 15-17, 2010.
80. Julia Coppin, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti,
Qing-Li Wu and James E. Simon. Polyphenol Stability in Grape Seed
Extract and Consistency in Grape Juice using LC/UV/MS Profiling.
Presented at the 3rd Annual Meeting Symposium of the CERC NIH Grant,
Mount Sinai School of Medicine. The Samuel Roberts Noble Foundation,
Ardmore, OK, September 15-17, 2010.
81. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,
Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Alice Cheng,
Connie M. Weaver, Susan S. Percival, Giulio Maria Pasinetti. Development
of brain-targeting grape-derived polyphenolics for Alzheimer’s disease
st
prevention and therapy. Invited oral presentation in 1 Annual Conference
of the American Council for Medicinally Active Plants (ACMAP), Brunswick,
NJ. July 20-23, 2010.
82. Qingli Wu. Using natural products chemistry for QC and botanical
st
standardization. Invited oral presentation in 1 Annual Conference of the
American Council for Medicinally Active Plants (ACMAP), New Brunswick,
NJ. July 20-23, 2010.
83. Jim Simon, Rodolfo Juliani, Chung H. Park, Christian A. Wyenandt, Julia
Coppin and Qingli Wu. Breeding for active principles in aromatic plants and
st
herbs. 1 Annual Conference of the American Council for Medicinally Active
Plants (ACMAP), New Brunswick, NJ. July 20-23, 2010.
84. Christopher R Racine, Molly E Seidler, Dustin L Moore, Robert T Harris,
Qingli Wu, James E Simon, Kit L Chin, Gerald R Hankins. Anti-tumor
properties and effects on vascular smooth muscle cell proliferation and
st
migration of extracts of Hibiscus sabdariffa accessions. 1
Annual
Conference of the American Council for Medicinally Active Plants (ACMAP),
New Brunswick, NJ. July 20-23, 2010.
85. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,
Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Connie M. Weaver,
Susan S. Percival, Giulio Maria Pasinetti. Bioavailability of grape –derived
polyphenolics and implication in Alzheimer’s disease prevention and
therapy. Experimental and Biology Meeting, Anaheim, CA. April 24-28,
2010.
86. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,
Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Alice Cheng,
Connie M. Weaver, Susan S. Percival, Giulio Maria Pasinetti. Development
of brain-targeting grape-derived polyphenolics for Alzheimer’s disease
prevention and therapy. Society for neuroscience Meeting. San Diego, CA.
November 13-17, 2010.
87. P. Marambaud, V. Vingtdeux,Giliberto L, H. Zhao, P. Chandakkar, Q. Wu,
J. E. Simon, E. M. Janle, J. Lobo, M. G. Ferruzzi and P. Davies, Resverptrol
lowers amyloid-beta accumulation and deposition in vivo by controlling
AMPK signaling. Presented at the International Conference on Alzhemer’s
Disease. Thessaloniki, Macedonia, Greece, March 10-13, 2010.
88. Qing-Li Wu. Plant and Human Heath-Case Studies on Polyphenol. Invited
oral presentation at Anhui College of TCM, Hefei, China. October 5, 2009.
89. J.K. Lobo, M.G. Ferruzzi, E.M. Janle, N. Whittaker, B.R. Cooper, C.M. Wea
ver, J.E. Simon, Q. Wu, C. Welch, L. Ho, G.M. Pasinetti. Bioavailability of
gallic acid and catechins from neuroprotective grape seed extract is
improved by repeated dosing in rats. Presented at the 2nd Annual Meeting
Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New
York, NY, September 28-29, 2009.
90. Qing-Li Wu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti and
James E. Simon. Chemical Profiling of Polyphenols in Grape Wine and
Grape Juice using LC/UV/MSD. Presented at the 2nd Annual Meeting
Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New
York, NY, September 28-29, 2009.
91. V. Vingtdeux, H. Zhao, P. Chandakkar, Q. Wu, J. E. Simon, E. M. Janle, J.
Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud. AMPK signaling
activation by resveratrol controls Abeta accumulation in vivo. Presented at
the 2nd Annual Meeting Symposium of the CERC NIH Grant, Mount Sinai
School of Medicine. New York, NY, September 28-29, 2009.
92. V. Vingtdeux, H. Zhao, P. Chandakkar, Q. Wu, J. E. Simon, E. M. Janle, J.
Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud. Resverptrol Controls
of Abeta levels, amyloid deposition, and activation of AMP-activated protein
kinase. Presented at the 2nd Annual Meeting Symposium of the CERC NIH
Grant, Mount Sinai School of Medicine. New York, NY, September 28-29,
2009.
93. J.K. Lobo, M.G. Ferruzzi, E.M. Janle, N. Whittaker, B.R. Cooper, C.M. Wea
ver, J.E. Simon, Q. Wu, C. Welch, L. Ho, G.M. Pasinetti. Bioavailability of
gallic acid and catechins from neuroprotective grape seed extract is
improved by repeated dosing in rats. Presented at Experimental Biology.
New Orleans, LA. 2009.
94. Cara R. Welch, Qing-Li Wu, Slavko Komarnytsky, Ilya Raskin and James E.
Simon. IDENTIFICATION OF THE BIOACTIVE CONSTITUENTS OF
SENEGAL’S BUSH TEA, KINKELIBA (COMBRETUM MICRANTHUM). The
50th Anniversary Meeting of the American Society of Pharmacognosy
(ASP). June 27, 2009. Honolulu, Hawaii, USA.
95. Qing-Li Wu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti and
James E. Simon. Chemical Profiling of Polyphenols in Grape Wine and
Grape Juice using LC/UV/MSD. The 50th Anniversary Meeting of the
American Society of Pharmacognosy (ASP). June 27, 2009. Honolulu,
Hawaii, USA.
96. Shen, D., Wu, Q. L. , Park, C. H. , Juliani, H. R. , Pan, M.H., Ho, C.T.,
Simon, J.E. .Investigation of Anti-inflammatory Compounds in Origanum
spp. 236th ACS National Meeting & Exposition. Philadelphia, PA, USA,
August 17-21, 2008.
97. Welch, C.R., Wu Q.L., Pan, M.H., Ho, C.T., Simon, J.E. Complete
Investigation into Kinkéliba (Combretum micranthum) for Bioactive
compounds. 236th ACS National Meeting & Exposition. Philadelphia, PA,
USA, August 17-21, 2008.
98. Xu, Y.P., Wu Q.L., Pan, M.H., Ho, C.T., Simon, J.E. Phytochemical
Screening and Bioactive Properties of the Medicinal Plant Eyebright,
Euphrasia officinalis. 236th ACS National Meeting & Exposition.
Philadelphia, PA, USA, August 17-21, 2008. 236th ACS National Meeting &
Exposition. Philadelphia, PA, USA, August 17-21, 2008.
99. Coppin, J.P., Xu, Y.P., Chen, H., Juliani, J., Wu Q.L., Simon, J.E.
Determination of flavonoids in Moringa Oleifera by LC/UV/MSD. 236th ACS
National Meeting & Exposition. Philadelphia, PA, USA, August 17-21, 2008.
236th ACS National Meeting & Exposition. Philadelphia, PA, USA, August
17-21, 2008.
100. Qing-Li Wu and James E. Simon. Development of Valuable
Natural Products and Botanicals-Case Studies on Polyphenol. Invited oral
presentation at Tea Research Institute, Chinese Academy of Agricultural
Sciences, Hangzhou, China. July 15, 2008.
101. Qing-Li Wu and James E. Simon. The Status of Dietary Supplements, The
Regulatory Environment and Phytomedicine Research in the USA. Invited
oral presentation at School of Pharmacy, Jiaotong University, Shanghai,
China. July 14, 2008.
102. Qing-Li Wu and James E. Simon. The Regulatory Environment, the Status
of Dietary Supplements and Phytomedicines in the USA and Europe.
Invited oral presentation at Institute of Medicinal Plant Development, Peking
Union Medical College and Chinese Academy of Medical Sciences, Beijing,
China. June 26, 2008.
103. Qing-Li Wu and James E. Simon. Medicinal Plants of Africa. Invited oral
presentation at Institute of Medicinal Plant Development, Peking Union
Medical College and Chinese Academy of Medical Sciences, Beijing,
China. June 26, 2008.
104. Cara Welch, Qingli Wu, James E. Simon. Antioxidant Capacity and Antiinflammatory Activity of Kinkeliba Polyphenols. Presented at the 8th Meeting
of the Purdue/Alabama National Botanical Center. Birmingham, AL, March
2, 2008.
105. Yanping Xu, Qingli Wu, James E. Simon. Phytochemical investigation and
Biactive Study on Eyebright (Euphrasia officinalis). Presented at the 8th
Meeting of the Purdue/Alabama National Botanical Center. Birmingham,
AL, March 2, 2008.
106. Diandian Shen, QingLi Wu, Chung-Heon Park, Rodolfo Juliani and James
E. Simon. Development of Anti-inflammatory Agents from the Non-volatile
Component of Oregano. Presented at the 8th Meeting of the
Purdue/Alabama National Botanical Center. Birmingham, AL, March 2,
2008.
107. Simon, J.E., Q.L. Wu, R. Juliani, D. Acquaye, E. Jefthas. CHEMDRAWN
XII. Stellenbosch University, Stellenbosch, South Africa. Dec. 03-07, 2007.
The Role of Chemistry in Sustainable Agriculture and Human Wellbeing in
Africa. Invited presentation on: Role of Chemistry and Natural Products to
Improve Health and Nutrition in Africa.
108. Simon, J.E., Qing-Li Wu, Rodolfo Juliani. Future Role for Horticulture in
Medicinal and Aromatic Plants. Keynote Speaker for the International
Symposium on Medicinal and Nutraceutical Plants, Macon, Georgia. March
20, 2007.
109. Qing-Li Wu, and Jim Simon (2007), Chemical Analysis of Eyebright Using
LC/UV/MS. Presented at the 7th Meeting of the Purdue/Alabama National
Botanical Center. West Lafayette, IN, February 23, 2007.
110. Cara Welch, Qing-Li Wu, Rodolfo Juliani and Jim Simon (2007)
Polyphenols from Hibiscus: A New Promising Source of Anthocyanins.
Presented at the 7th Meeting of the Purdue/Alabama National Botanical
Center. West Lafayette, IN, February 23, 2007.
111. Simon, J.E., Q.L. Wu, R. Juliani, D. Acquaye, E. Jefthas. CHEMDRAWN
XII. 2007. Stellenbosch University, Stellenbosch, South Africa. Dec. 03-07,
2007. The Role of Chemistry in Sustainable Agriculture and Human
Wellbeing in Africa. Invited presentation on: Role of Chemistry and Natural
Products to Improve Health and Nutrition in Africa.
112. 2007. Simon, J.E., Qing-Li Wu, Rodolfo Juliani. Future Role for Horticulture
in Medicinal and Aromatic Plants. Keynote Speaker for the International
Symposium on Medicinal and Nutraceutical Plants, Macon, Georgia. March
20, 2007.
113. Simon, J.E., R. Juliani, M. Wang and Q.L. Wu. Botanicals for Energy in
Beverages: Long Distance Learning sponsored by IFT. Feb, 2007.
114. Simon, J.E. R. Juliani, Q. L. Wu and R. Govindasmay. Natural Products for
Health and Nutrition: Research Studies with Artemisia, Moringa and
Kombo. Inivted seminar, Departments of Food Science and Chemistry,
University of Ghana, East Legon, Accra, Ghana. February, 2007.
115. William J. Sciarappa, Laura K. Hunsberger , Diandian Shen, Qing-Li Wu,
Chung Park, Brian Hulme and Jim Simon. EVALUATION OF EDAMAME
VARIETIES IN THE MID-ATLANTIC. 2006 AAIC Annual Meeting and 6th
New Crops Symposium, San Diego, CA, October 14-18, 2006
116. J.E. Simon, C. Park, Q.L. Wu, M. Diatta, B. Diouf, B. Wilde, J. AsanteDartey, D. Acquaye, C. Quansah, R. Akromah, C. Giblain, G. Gbewonyo,
J. Ferreira, P. Melillo de Magalhães, D. Shen, N. Hitimani, A. Daka, H.
Malumo, J. Goliath, P. Langenhoven, R. Juliani and R. Govindasamy.
ARTEMISIA ANNUA: PRODUCTION IN SUB-SAHARAN AFRICA. 2006
AAIC Annual Meeting and 6th New Crops Symposium, San Diego, CA,
October 14-18, 2006.
117. James E. Simon, Chung Park, Qing-Li Wu, Pierre Tannous, William J.
Sciarappa, Mingfu Wang, Rick W. Van Vranken , Peter Nitzsche and Rodolfo
Juliani. CATMINT (NEPETA SPP.): AS A SOURCE OF ESSENTIAL OILS.
2006 AAIC Annual Meeting and 6th New Crops Symposium, San Diego, CA,
October 14-18, 2006.
118. Qing-Li Wu and James E. Simon. Development of valuable natural products
and botanicals-Case study of kudzu. Invited oral presentation on The 9th
International Congress on Ethnopharmacology. Nanning, China, August 2226, 2006.
119. Qing-Li Wu, Yong-hong Yang and James E. Simon. Chemical profiling and
quantification of isoflavone phytoestrogens in kudzu using LC/UV/MSD. 54th
ASMS Conference on Mass Spectrometry. Seattle, WA, may 28-June 1,
2006.
120. Qing-Li Wu, Yong-hong Yang and James E. Simon. Plant Sourcing of
Isoflavone Enriched Kudzu Species (Pueraria spp.). Presented at the 6th
Meeting of the Purdue/Alabama National Botanical Center. Birmingham,
AL, March 3, 2006.
121. Diandian Shen, Qing-Li Wu and Jim Simon. Determination of the
Predominant Catechins in Acacia catechu by LC/MS. Presented at the 6th
Meeting of the Purdue/Alabama National Botanical Center. Birmingham, AL,
March 3, 2006.
122. Diandian Shen, Qing-Li Wu and Jim Simon. An Analytical Survey of
Isoflavones in Tofu-type Soybeans Cultivated in North America. Presented at
the 6th Meeting of the Purdue/Alabama National Botanical Center.
Birmingham, AL, March 3, 2006.
123. Qing-Li Wu and James E. Simon. Development of Natural Products and
Botanicals for Health and medicine. Invited presentation at School of
Chinese Medicine, Hong Kong Babtist University, Kowloon, HK. December
1, 2005.
124. Qing-Li Wu and James E. Simon. Modern Analytical Methodologies in
Natural Products Chemistry, Case study on Phytoestrogens. Invited
presentation at Institute of Medicinal Plant Development, Peking Union
Medical College and Chinese Academy of Medical Sciences, Beijing, China.
December, 2005.
125. Qing-Li Wu and James E. Simon. Modern Analytical Methodologies in
Natural Products Chemistry, Purdue University-University of Alabama
Botanical Center for Age Related Diseases, 2005 Workshop: Botanical
Standardization of Medicinal Plants, Cook College, New Brunswick, NJ.
October 20- 21, 2005.
126. Jim Simon, Qing-Li Wu, Mingfu Wang and Rodolfo Juliani. The World of
Nutraceuticals- and Background of the New Use Agriculture & Natural Plant
Products Program, Purdue University-University of Alabama Botanical
Center for Age Related Diseases, 2005 Workshop: Botanical Standardization
of Medicinal Plants, Cook College, New Brunswick, NJ. October 20- 21,
2005.
127. Jim Simon and Qing-Li Wu. Traceability and Botanical Standardization:
Challenges and Approaches, Purdue University-University of Alabama
Botanical Center for Age Related Diseases, 2005 Workshop: Botanical
Standardization of Medicinal Plants, Cook College, New Brunswick, NJ.
October 20- 21, 2005.
128. Qing-Li Wu and James E. Simon. Development of Valuable Natural
Products and Botanicals. Presented at Institute of Medicinal Plant
Development, Peking Union Medical College and Chinese Academy of
Medical Sciences, Beijing, China. August 24, 2005.
129. James E. Simon, Qing-Li Wu, Mingfu Wang and Rodolfo Juliani. Research,
Discovery and Application of Natural Products for Health and Medicine.
Gordon Conference, NH, July 10, 2005.
130. Qing-Li Wu, Yong-Hong Yang, MingFu Wang and James E. Simon.
Determination of isoflavones in kudzu by LC/UV/MSD. Presented at the 5th
Meeting of the Purdue/Alabama National Botanical Center. February 25-26,
2005.
131. Simon, J.E., Q.L. Wu, M. Wang and R. Juliani. Research, Discovery and
Application of Natural Products for Health and Medicine. Invited openning
speaker in Plant Chemistry and EthnoBotany, Plant Metabolic Engineering.
Gordon Conference, Tilton, New Hampshire, July 10, 2005.
132. Simon, J.E., R. Govindasamy, R. Juliani, D. Acquaye, E. Jefthas, N.
Hitimana, J. Goliath, P. Langenhoven, A.E. Daka, M. Diatta, J.AstanteDartey, D.Alipoe, Q.L. Wu and C. Quansah. Sustainable Development:
Natural Products and Medicinal Plants Sector Using a Science and MarketDriven Approach to Strengthen Demand. Building New Partnerships in the
Global Food Chain. Experiences from North Africa, the Near East and Asia.
A USAID and Univ. of Illinois Post-IAMA Workshop, June 29-30, 2005.
Chicago, Ill. Simon also served as a co-Moderator with Scott Christiansen,
USAID for the natural products session. (a special symposia paper has
been requested for all presenters for publication).
133. Simon, J.E., E. Jefthas, D. Acquaye, R. Juliani, H. Moharram, P.
Langenhoven, P. Tannous & M. Wang, Q.L Wu, E. Renaud, B. Neimark, D.
Alipoe, K. Chin, J. Dartey-Asante, C. Quansah, M. Diatta, N. Hitimana and
A. Daka. Natural Products: From Bush to Processed Product: Natural
Products and Medicinal Plants Sector Developing the Market for Natural
Products Using a Sustainable Approach. A Model for International
Development. Invited presentation for the session on Sustainable
Development. Trading morsels, Growing Hunger, Decimating Nature:
Linking Food and Trade Development and the Environment. Princeton
Institute for International and Regional Studies, Princeton University,
Princeton, New Jersey, February 24-26, 2005. (all invited papers now
invited to submit a special symposia paper on the ASNAPP model for J.
Food, People, Culture and Society).
134. Simon, J.E., R. Juliani, Q.L. Wu and M. Wang. Processing Technologies
and Packaging Systems – From the Simple to Complex. Making Quality
Matter Workshop, ASNAPP, Accra, Ghana, June, 2005.
135. Simon, J.E., C.h. Park, Q.L. Wu and M. Wang. The anti-malarial Artemisia
annua: From Botany and Biology, through Chemistry and Pharmacology to
Production, Processing and Post-harvest handling. Making Quality Matter
Workshop, ASNAPP, Accra, Ghana, June, 2005.
137. Simon, J.E., M. Wang, R. Juliani, Q.L. Wu, H. Moharram and M. Rafi.
Research, Discovery and Application of Natural Products for Health and
Medicine. Campinas, Brazil, 2004.
138. Simon, J.E., M. Wang and Q-L. Wu. New Trends in the Research, Discovery
and Application of Natural Products for Health and Medicine. Prestented at
the Laboratorio de Fitofármacos. Hospital de Especialidades Centro Médico
Nacional Siglo XXI, IMSS. April 28, 2004, Mexico City, Mexico.
139. Simon, J.E., M. Wang, Q-L. Wu, R. Juliani, H. Moharram and P. Tannous.
Quality Control Issues Facing Botanicals and Dietary Supplements.
Prestented at the Laboratorio de Fitofármacos. Hospital de Especialidades
Centro Médico Nacional Siglo XXI, IMSS. April 28, 2004, Mexico City,
Mexico.
140. Simon, J.E., H. Moharram, M. Wang, Q.L. Wu, P. Tannous, and R. Juliani.
Strategies for Commercializing Plants Targeted for Natural Products. April
01, 2004. Dupont Chemical Science and Engineering Division. Dupont
Central Research and Development Experiment Station, Wilmington,
Delaware (industry invitation).
143. 2004. Simon, J.E., M. Wang, Q.-L. Wu, C.K. Chin, S. Garrison, B. Sciarappa,
P. Nitzsche, T.C. Lee, W. Kline and R. VanVranken. New Products from
Asparagus, Artichokes, Edamame Soy and Herbs Presentation for the
Annual Meeting of the New Jersey Vegetable Growers, New Jersey Farm
Bureau. Atlantic City, NJ. January 12, 2004.
144. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of
proanthocyanidins in fresh grape and grape products. Presented at the 4th
Meeting of the Purdue/Alabama National Botanical Center. February 25-26,
2004.
145. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of
proanthocyanidins
in
areca
nuts
by
high-performance
liquid
chromatography combined with electrospray ionization ion trap mass
spectrometry. Presented at the 4th Meeting of the Purdue/Alabama National
Botanical Center. February 25-26, 2004.
146. Qing-Li Wu, MingFu Wang and James E. Simon. Determination of
Isoflavones in Red Clover and Related Species by LC/UV/ESI-MS, American
Chemical Society Annual Meetings, New York, NY, Sept. 8-11, 2003 (invited
oral presentation).
147. Qing-Li Wu, M. Wang, J. Kapteyn, R. Juliani, and J.E. Simon. Quality Control
in Botanicals & Herbal Drugs and Issues Facing Botanicals Used in the
Natural Products/Nutraceuticals Industry. Invited Lecture and Workshop.
Sept 25-26, 2003, Purdue University, West Lafayette, IN.
148. William J. Sciarappa, Peter Nitzsche, Qing-Li Wu, Ming-Fu Wang, Jim Simon
and Tung-Ching Lee, Phytochemistry and Horticultural properties of 16
Edamame Soybean Varieties. Annual Meeting of the American Society for
Horticultural Science, Providence, Rhode Island. October 06, 2003.
149. MingFu Wang, Rodolfo Juliani, Qing-Li Wu and James E. Simon. Analysis of
flavonoids and rosmarinic acid contents in different varieties of mint by HPLC
and LC-MS Methods. American Chemical Society Annual Meetings, New
York, NY, Sept. 8-11, 2003 (invited oral presentation).
150. Ming-Fu Wang, Qing-Li Wu, Jerimy Kapteyn, Rodolfo Juliani and J.E.Simon.
Health Promoting Components in Asparagus, Artichokes and Other Foods.
Foods for Health: A Look To the Future. For Health Care Professionals,
Nurses, Dieticians and Health Care and Extension Specialists. Rutgers
University, New Brunswick, NJ. September 10, 2003.
151. Qing-Li Wu, Ming-Fu Wang, James E. Simon. Determination of Isoflavones
in Red Clover and Related Species by LC/UV/MSD. Presented at the 3rd
Meeting of the Purdue/Alabama National Botanical Center. February 25-26,
2003.
152. Zhong-zhe Ma, David Y. W. Lee, Qing-Li Wu, SE Lukas, Determination of
Puerarin in Human Plasma and Urine. American Chemical Society Annual
Meetings, New York, NY, Sept. 8-11, 2003.
153. Qing-Li Wu, Ming-Fu Wang, James E. Simon. LC/UV/ESI-MS Analysis of
Isoflavones in Immature Fresh Soy Seeds. Presented at the 3rd Meeting of
the Purdue/Alabama National Botanical Center. February 25-26, 2003.
154. Qing-Li Wu, Mingfu Wang, and James E. Simon, The Botanical Core,
Method Development, and Determination of Isoflavones by LC/MSD.
Presented as a distance-learning seminar to the Botanical Center Seminar
Series, Purdue/Alabama/Rutgers. November 14, 2002.
155. Qing-Li Wu, Ming-Fu Wang, Rodolfo Juliani, Adolfina Koroch, Jeremy
Kapteyn, ChungHeon Park, David Rotter, Cicero Dechamps, Insong Han,
Kobi Tadmor, Erica Renaud, Kathleen Shimomura and James E. Simon:
New Use Agriculture and Natural Plant Products Program. 43rd Annual
Meeting of the American Society of Pharmacognosy and 3 rd Monroe Wall
Symposium, New Brunswick, NJ. July 27-31, 2002.
156. Qing-Li Wu, Ming-Fu Wang and James E. Simon. Determination of
Proanthocynidins in grape products by LC/MSD. 43rd Annual Meeting of the
American Society of Pharmacognosy and 3rd Monroe Wall Symposium,
New Brunswick, NJ. July 27-31, 2002.
157. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of
proanthocyanidins in grape products by LC/MSD. Presented at the 2nd
Meeting of the Purdue/Alabama National Botanical Center. February 25-26,
2002.
158. Qing-Li Wu, Mingfu Wang, and James E. Simon. The Botanical Core and
Quantitative Determination of Monoproanthocyanidins and Estimation of
Oligoproanthacyanidins in Grape Products by LC/MSD. Presented as a
distance-learning seminar to the Botanical Center Seminar Series,
Purdue/Alabama/Rutgers. December 20, 2001.
159. Qing-Li Wu, Ming-Fu Wang, Rodolfo Juliani, Adolfina Koroch, Jeremy
Kapteyn, Wudeneh Letchamo and James E. Simon. (2001): New Use
Agriculture and Natural Plant Products Program. 5th National Symosium
New Crops and New Uses: Strenght in Diversity, Altlanta, Georgia. Nov. 1012. 2001.
160. David Zaurov, James E. Simon, Qing-Li Wu and Ming-Fu Wang. Medicinal
Plant from Central and Western Asia. 5th National Symosium New Crops
and New Uses: Strenght in Diversity, Altlanta, Georgia. Nov. 10-12. 2001.
161. Qing-Li Wu, J.E. Simon, R. Juliani, A. Koroch, J. Kapteyn, K. Shawe, K.
Shimomura, and C.Santerre. Botanical Center and Age-Related Diseases.
Core B. Botanical and Educational Outreach. Presented at the 1st Meeting
of the Purdue/Alabama National Botanical Center. February 25-26, 2001.
162. J. L. Neumeyer, J. Bergman, N. S. Kula, Qing-Li Wu, G. Leclerc, P. Nguyen
and R. J. R. J. Baldessarini. Characterization of Novel D1 Partial-Agonists
for the Treatment of Psychostimulant Addiction. 2000 Annual Meeting of
Society for Neuroscience, P2153, 809.2, New Orleans, LA. November 4,
2000.
163. Qing-Li Wu, Yu-xiu Feng, Shao-mei Shun and yu-Mei Shong, (1994):
Pharmcognostic Study on Piper Species. The 3rd International Congress on
Ethnopharmcology, Beijing, China, Sept. 6, 1994, C-28.