PRODUCT DATA SHEET
Recombinant Human ER (ER alpha)
Catalog Number: 90039
Description: This product is the N-terminal region of estrogen receptor. ER is a ligand-activated transcription factor
composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein
localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its
receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone.
Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis
PRODUCT SPECIFICATIONS
Product Details: Purified human recombinant ER (ER
alpha) protein (amino acids 2-181, 180 a.a.) produced in
human cells. (Accession NP_000116.2; UniProt P03372)
Purity: >95% pure by SDS-PAGE
Source: Human cell line
Formulation: Lyophilized from 0.2µm filtered solution in
0.3X PBS with 10% Trehalose (carrier-free).
Endotoxin: <0.1EU per g protein by LAL method
Predicted Molecular Weight: 19.4 kDa
Tag: StrepII at N
Cell Culture Medium: Chemically-defined, serum- and
animal-product-free culture medium
Reconstitution: Centrifuge the vial prior to opening.
Reconstitute in PBS to a concentration of 0.1 mg/ml.
Stability & Storage: 12 months at -20°C as supplied; 1
month at 4°C after reconstitution. Avoid freeze/thaw
cycles.
Sequence: TMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGG
FPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKE
SDS-PAGE of 2 g purified recombinant ER (ER alpha).
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
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