Rheumatoid - Inflammatory Diseases Markers Tests

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Rheumatoid - Inflammatory Diseases Markers Tests
- Pipeline Review, 2015
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Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Review, 2015
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October 1, 2015
114
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R7B894CBE73EN
Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Review, 2015
Summary
GlobalData's Medical Devices sector report, “Rheumatoid - Inflammatory Diseases Markers Tests Pipeline Review, 2015' provides an overview of Rheumatoid - Inflammatory Diseases Markers Tests
currently in pipeline stage.
The report provides comprehensive information on the pipeline products with comparative analysis of the
products at various stages of development. The report reviews major players involved in the pipeline
product development. It also provides information about clinical trials in progress, which includes trial
phase, trial status, trial start and end dates, and, the number of trials for the key Rheumatoid - Inflammatory
Diseases Markers Tests pipeline products.
This report is prepared using data sourced from in-house databases, secondary and primary research by
GlobalData's team of industry experts.
Note: Certain sections in the report may be removed or altered based on the availability and relevance of
data in relation to the equipment type.
Scope
Extensive coverage of the Rheumatoid - Inflammatory Diseases Markers Tests under development
The report reviews details of major pipeline products which includes, product description, licensing
and collaboration details and other developmental activities
The report reviews the major players involved in the development of Rheumatoid - Inflammatory
Diseases Markers Tests and list all their pipeline projects
The coverage of pipeline products based on various stages of development ranging from Early
Development to Approved / Issued stage
The report provides key clinical trial data of ongoing trials specific to pipeline products
Recent developments in the segment / industry
Reasons to buy
The report enables you to
Formulate significant competitor information, analysis, and insights to improve R&D strategies
Identify emerging players with potentially strong product portfolio and create effective
counter-strategies to gain competitive advantage
Identify and understand important and diverse types of Rheumatoid - Inflammatory Diseases
Markers Tests under development
Develop market-entry and market expansion strategies
Plan mergers and acquisitions effectively by identifying major players with the most promising
pipeline
Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Review, 2015
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In-depth analysis of the product’s current stage of development, territory and estimated launch date
Table of Content
1 TABLE OF CONTENTS
LIST OF TABLES
LIST OF FIGURES
2 INTRODUCTION
2.1 Rheumatoid - Inflammatory Diseases Markers Tests Overview
3 PRODUCTS UNDER DEVELOPMENT
3.1 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Stage of Development
3.2 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Segment
3.3 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Territory
3.4 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Regulatory Path
3.5 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Estimated Approval Date
4 RHEUMATOID - INFLAMMATORY DISEASES MARKERS TESTS - PIPELINE PRODUCTS UNDER
DEVELOPMENT BY COMPANIES
4.1 Rheumatoid - Inflammatory Diseases Markers Tests Companies - Pipeline Products by Stage of
Development
4.2 Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Stage of Development
5 RHEUMATOID - INFLAMMATORY DISEASES MARKERS TESTS COMPANIES AND PRODUCT
OVERVIEW
5.1 Abcodia Ltd. Company Overview
5.1.1 Abcodia Ltd. Pipeline Products & Ongoing Clinical Trials Overview
5.2 Albert-Ludwigs-Universitat Freiburg Company Overview
5.2.1 Albert-Ludwigs-Universitat Freiburg Pipeline Products & Ongoing Clinical Trials Overview
5.3 Analyticon Biotechnologies AG Company Overview
5.3.1 Analyticon Biotechnologies AG Pipeline Products & Ongoing Clinical Trials Overview
5.4 AnaMar AB Company Overview
5.4.1 AnaMar AB Pipeline Products & Ongoing Clinical Trials Overview
5.5 Bayerische Patentallianz GmbH Company Overview
5.5.1 Bayerische Patentallianz GmbH Pipeline Products & Ongoing Clinical Trials Overview
5.6 Beckman Coulter, Inc. Company Overview
5.6.1 Beckman Coulter, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.7 BioSIMS Company Overview
5.7.1 BioSIMS Pipeline Products & Ongoing Clinical Trials Overview
5.8 CD Diagnostics, Inc. Company Overview
5.8.1 CD Diagnostics, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.9 Chronix Biomedical, Inc. Company Overview
5.9.1 Chronix Biomedical, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.10 Consejo Superior de Investigaciones Cientificas Company Overview
5.10.1 Consejo Superior de Investigaciones Cientificas Pipeline Products & Ongoing Clinical Trials
Overview
5.11 Crescendo Bioscience, Inc. Company Overview
5.11.1 Crescendo Bioscience, Inc. Pipeline Products & Ongoing Clinical Trials Overview
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5.12 DIESSE Diagnostica Senese S.p.A. Company Overview
5.12.1 DIESSE Diagnostica Senese S.p.A. Pipeline Products & Ongoing Clinical Trials Overview
5.13 DSX Therapeutics Company Overview
5.13.1 DSX Therapeutics Pipeline Products & Ongoing Clinical Trials Overview
5.14 Fundacio Clinic per a la Recerca Biomedica Company Overview
5.14.1 Fundacio Clinic per a la Recerca Biomedica Pipeline Products & Ongoing Clinical Trials Overview
5.15 Genalyte, Inc. Company Overview
5.15.1 Genalyte, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.16 GeneNews Limited Company Overview
5.16.1 GeneNews Limited Pipeline Products & Ongoing Clinical Trials Overview
5.17 Ghent University Company Overview
5.17.1 Ghent University Pipeline Products & Ongoing Clinical Trials Overview
5.18 Ignyta, Inc. Company Overview
5.18.1 Ignyta, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.19 Institut National de la Sante et de la Recherche Medicale Company Overview
5.19.1 Institut National de la Sante et de la Recherche Medicale Pipeline Products & Ongoing Clinical
Trials Overview
5.20 KineMed, Inc. Company Overview
5.20.1 KineMed, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.21 Louisville Bioscience, Inc. Company Overview
5.21.1 Louisville Bioscience, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.22 Myriad Genetics, Inc. Company Overview
5.22.1 Myriad Genetics, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.23 Proplex Technologies, Llc Company Overview
5.23.1 Proplex Technologies, Llc Pipeline Products & Ongoing Clinical Trials Overview
5.24 Protagen AG Company Overview
5.24.1 Protagen AG Pipeline Products & Ongoing Clinical Trials Overview
5.25 Selventa Company Overview
5.25.1 Selventa Pipeline Products & Ongoing Clinical Trials Overview
5.26 Siemens Healthcare Diagnostics Inc. Company Overview
5.26.1 Siemens Healthcare Diagnostics Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.27 Singulex, Inc. Company Overview
5.27.1 Singulex, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.28 SomaLogic, Inc. Company Overview
5.28.1 SomaLogic, Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.29 SQI Diagnostics Inc. Company Overview
5.29.1 SQI Diagnostics Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.30 The Binding Site Group Ltd. Company Overview
5.30.1 The Binding Site Group Ltd. Pipeline Products & Ongoing Clinical Trials Overview
5.31 The Johns Hopkins University Company Overview
5.31.1 The Johns Hopkins University Pipeline Products & Ongoing Clinical Trials Overview
5.32 Thermo Fisher Scientific Inc. Company Overview
5.32.1 Thermo Fisher Scientific Inc. Pipeline Products & Ongoing Clinical Trials Overview
5.33 Toscana Biomarkers Srl Company Overview
5.33.1 Toscana Biomarkers Srl Pipeline Products & Ongoing Clinical Trials Overview
5.34 University of Aberdeen Company Overview
5.34.1 University of Aberdeen Pipeline Products & Ongoing Clinical Trials Overview
5.35 University of Manchester Company Overview
5.35.1 University of Manchester Pipeline Products & Ongoing Clinical Trials Overview
5.36 University of Missouri Company Overview
5.36.1 University of Missouri Pipeline Products & Ongoing Clinical Trials Overview
5.37 University of Oxford Company Overview
5.37.1 University of Oxford Pipeline Products & Ongoing Clinical Trials Overview
5.38 University of Rochester Company Overview
5.38.1 University of Rochester Pipeline Products & Ongoing Clinical Trials Overview
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5.39 University of Warwick Company Overview
5.39.1 University of Warwick Pipeline Products & Ongoing Clinical Trials Overview
5.40 University Rovira i Virgili Company Overview
5.40.1 University Rovira i Virgili Pipeline Products & Ongoing Clinical Trials Overview
6 RHEUMATOID - INFLAMMATORY DISEASES MARKERS TESTS- RECENT DEVELOPMENTS
7 APPENDIX
7.1 Methodology
7.2 About GlobalData
7.3 Contact Us
7.4 Disclaimer 114
LIST OF TABLES
Table 1: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Stage of Development
Table 2: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Segment
Table 3: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Territory
Table 4: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Regulatory Path
Table 5: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Estimated Approval
Date
Table 6: Rheumatoid - Inflammatory Diseases Markers Tests Companies - Pipeline Products by Stage of
Development
Table 7: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Stage of Development
Table 8: Abcodia Ltd. Pipeline Products & Ongoing Clinical Trials Overview
Table 9: Molecular Biomarker - Rheumatoid Arthritis - Product Status
Table 10: Molecular Biomarker - Rheumatoid Arthritis - Product Description
Table 11: Albert-Ludwigs-Universitat Freiburg Pipeline Products & Ongoing Clinical Trials Overview
Table 12: Diagnostic Kit - Rheumatoid Arthritis - Product Status
Table 13: Diagnostic Kit - Rheumatoid Arthritis - Product Description
Table 14: Analyticon Biotechnologies AG Pipeline Products & Ongoing Clinical Trials Overview
Table 15: Turbitex ASL - Product Status
Table 16: Turbitex ASL - Product Description
Table 17: AnaMar AB Pipeline Products & Ongoing Clinical Trials Overview
Table 18: NeoSix Biomarker Assay - Product Status
Table 19: NeoSix Biomarker Assay - Product Description
Table 20: Bayerische Patentallianz GmbH Pipeline Products & Ongoing Clinical Trials Overview
Table 21: Prognostic Test - Rheumatoid Arthritis - Product Status
Table 22: Prognostic Test - Rheumatoid Arthritis - Product Description
Table 23: Beckman Coulter, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 24: AU480 Clinical System - anti-CCP Assay - Product Status
Table 25: AU480 Clinical System - anti-CCP Assay - Product Description
Table 26: AU5810 Clinical System - anti-CCP Assay - Product Status
Table 27: AU5810 Clinical System - anti-CCP Assay - Product Description
Table 28: AU5820 Clinical System - anti-CCP Assay - Product Status
Table 29: AU5820 Clinical System - anti-CCP Assay - Product Description
Table 30: AU5830 Clinical System - anti-CCP Assay - Product Status
Table 31: AU5830 Clinical System - anti-CCP Assay - Product Description
Table 32: AU5840 Clinical System - anti-CCP Assay - Product Status
Table 33: AU5840 Clinical System - anti-CCP Assay - Product Description
Table 34: AU680 Clinical System - anti-CCP Assay - Product Status
Table 35: AU680 Clinical System - anti-CCP Assay - Product Description
Table 36: UniCel DxC 600 Synchron Access - anti-CCP Assay - Product Status
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Table 37: UniCel DxC 600 Synchron Access - anti-CCP Assay - Product Description
Table 38: UniCel DxC 600i Synchron Access - anti-CCP Assay - Product Status
Table 39: UniCel DxC 600i Synchron Access - anti-CCP Assay - Product Description
Table 40: UniCel DxC 660i Synchron Access - anti-CCP Assay - Product Status
Table 41: UniCel DxC 660i Synchron Access - anti-CCP Assay - Product Description
Table 42: UniCel DxC 680i Synchron Access Clinical System - anti-CCP Assay - Product Status
Table 43: UniCel DxC 680i Synchron Access Clinical System - anti-CCP Assay - Product Description
Table 44: UniCel DxC 800 Synchron Access Clinical System - anti-CCP Assay - Product Status
Table 45: UniCel DxC 800 Synchron Access Clinical System - anti-CCP Assay - Product Description
Table 46: UniCel DxC 860i Synchron Access Clinical System - anti-CCP Assay - Product Status
Table 47: UniCel DxC 860i Synchron Access Clinical System - anti-CCP Assay - Product Description
Table 48: UniCel DxC 880i Synchron Access Clinical System - anti-CCP Assay - Product Status
Table 49: UniCel DxC 880i Synchron Access Clinical System - anti-CCP Assay - Product Description
Table 50: BioSIMS Pipeline Products & Ongoing Clinical Trials Overview
Table 51: DigiPLEX Analyzer - Rheumatology Assay - Product Status
Table 52: DigiPLEX Analyzer - Rheumatology Assay - Product Description
Table 53: CD Diagnostics, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 54: Cygnasure Diagnostic Immunoassay - Rheumatoid Arthritis - Product Status
Table 55: Cygnasure Diagnostic Immunoassay - Rheumatoid Arthritis - Product Description
Table 56: Chronix Biomedical, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 57: Companion Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 58: Companion Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 59: Consejo Superior de Investigaciones Cientificas Pipeline Products & Ongoing Clinical Trials
Overview
Table 60: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 61: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 62: Crescendo Bioscience, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 63: Vectra DA - Product Status
Table 64: Vectra DA - Product Description
Table 65: DIESSE Diagnostica Senese S.p.A. Pipeline Products & Ongoing Clinical Trials Overview
Table 66: Screening Kit - Rheumatologic Markers - Product Status
Table 67: Screening Kit - Rheumatologic Markers - Product Description
Table 68: DSX Therapeutics Pipeline Products & Ongoing Clinical Trials Overview
Table 69: Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 70: Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 71: Fundacio Clinic per a la Recerca Biomedica Pipeline Products & Ongoing Clinical Trials
Overview
Table 72: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 73: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 74: Early Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 75: Early Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 76: Genalyte, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 77: Maverick Rheumatoid Arthritis Multiplex Assay Kit - Product Status
Table 78: Maverick Rheumatoid Arthritis Multiplex Assay Kit - Product Description
Table 79: GeneNews Limited Pipeline Products & Ongoing Clinical Trials Overview
Table 80: Biomarker Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 81: Biomarker Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 82: Ghent University Pipeline Products & Ongoing Clinical Trials Overview
Table 83: Biomarker Test - Spondyloarthropathy - Product Status
Table 84: Biomarker Test - Spondyloarthropathy - Product Description
Table 85: Ignyta, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 86: CLIA Waived Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 87: CLIA Waived Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 88: TrailblazeDx Test - Rheumatoid Arthritis - Product Status
Table 89: TrailblazeDx Test - Rheumatoid Arthritis - Product Description
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Table 90: TrailblazeTx Test - Rheumatoid Arthritis - Product Status
Table 91: TrailblazeTx Test - Rheumatoid Arthritis - Product Description
Table 92: Institut National de la Sante et de la Recherche Medicale Pipeline Products & Ongoing Clinical
Trials Overview
Table 93: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 94: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 95: GPI Biomarker Assay - Arthritis - Product Status
Table 96: GPI Biomarker Assay - Arthritis - Product Description
Table 97: KineMed, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 98: Diagnostic Assay - Collagen Synthesis - Product Status
Table 99: Diagnostic Assay - Collagen Synthesis - Product Description
Table 100: Louisville Bioscience, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 101: Rheumatoid Arthritis pT Autoimmune Test - Product Status
Table 102: Rheumatoid Arthritis pT Autoimmune Test - Product Description
Table 103: Myriad Genetics, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 104: Psoriatic Arthritis - Product Status
Table 105: Psoriatic Arthritis - Product Description
Table 106: Proplex Technologies, Llc Pipeline Products & Ongoing Clinical Trials Overview
Table 107: Biomarker Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 108: Biomarker Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 109: Protagen AG Pipeline Products & Ongoing Clinical Trials Overview
Table 110: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 111: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 112: Selventa Pipeline Products & Ongoing Clinical Trials Overview
Table 113: Biomarker Panel - Rheumatoid Arthritis - Product Status
Table 114: Biomarker Panel - Rheumatoid Arthritis - Product Description
Table 115: Siemens Healthcare Diagnostics Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 116: ADVIA Centaur CP Immunoassay System - Anti-CCP Assay - Product Status
Table 117: ADVIA Centaur CP Immunoassay System - Anti-CCP Assay - Product Description
Table 118: ADVIA Centaur XP Immunoassay System - Anti-CCP Assay - Product Status
Table 119: ADVIA Centaur XP Immunoassay System - Anti-CCP Assay - Product Description
Table 120: ADVIA Centaur XPT Immunoassay System - Anti-CCP Assay - Product Status
Table 121: ADVIA Centaur XPT Immunoassay System - Anti-CCP Assay - Product Description
Table 122: Singulex, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 123: Erenna System - Rheumatoid Arthritis - Product Status
Table 124: Erenna System - Rheumatoid Arthritis - Product Description
Table 125: SomaLogic, Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 126: Somalogic Diagnostic Test - Rheumatoid Arthritis - Product Status
Table 127: Somalogic Diagnostic Test - Rheumatoid Arthritis - Product Description
Table 128: SQI Diagnostics Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 129: IgX PLEX Rheumatoid Arthritis Panel With Expanded Markers - Product Status
Table 130: IgX PLEX Rheumatoid Arthritis Panel With Expanded Markers - Product Description
Table 131: The Binding Site Group Ltd. Pipeline Products & Ongoing Clinical Trials Overview
Table 132: SPAplus - Rheumatoid Factor Assay - Product Status
Table 133: SPAplus - Rheumatoid Factor Assay - Product Description
Table 134: The Johns Hopkins University Pipeline Products & Ongoing Clinical Trials Overview
Table 135: Anti-PAD4 Based Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 136: Anti-PAD4 Based Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 137: Biomarker Assay - Rheumatoid Arthritis - Product Status
Table 138: Biomarker Assay - Rheumatoid Arthritis - Product Description
Table 139: Thermo Fisher Scientific Inc. Pipeline Products & Ongoing Clinical Trials Overview
Table 140: Phadia 2500 Laboratory System - CCP Test - Product Status
Table 141: Phadia 2500 Laboratory System - CCP Test - Product Description
Table 142: Phadia 5000 Laboratory System - CCP Test - Product Status
Table 143: Phadia 5000 Laboratory System - CCP Test - Product Description
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Table 144: Toscana Biomarkers Srl Pipeline Products & Ongoing Clinical Trials Overview
Table 145: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 146: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 147: University of Aberdeen Pipeline Products & Ongoing Clinical Trials Overview
Table 148: Diagnostic Assay - Rheumatoid Arthritis - Product Status
Table 149: Diagnostic Assay - Rheumatoid Arthritis - Product Description
Table 150: University of Manchester Pipeline Products & Ongoing Clinical Trials Overview
Table 151: Molecular Pathology Test - Rheumatoid Arthritis - Product Status
Table 152: Molecular Pathology Test - Rheumatoid Arthritis - Product Description
Table 153: University of Missouri Pipeline Products & Ongoing Clinical Trials Overview
Table 154: Biomarker Test - Arthritis - Product Status
Table 155: Biomarker Test - Arthritis - Product Description
Table 156: University of Oxford Pipeline Products & Ongoing Clinical Trials Overview
Table 157: Biomarker Based Assay - Rheumatoid Arthritis - Product Status
Table 158: Biomarker Based Assay - Rheumatoid Arthritis - Product Description
Table 159: University of Rochester Pipeline Products & Ongoing Clinical Trials Overview
Table 160: PBMC-Based Companion Diagnostic Test - Product Status
Table 161: PBMC-Based Companion Diagnostic Test - Product Description
Table 162: University of Warwick Pipeline Products & Ongoing Clinical Trials Overview
Table 163: Diagnostic Test - Arthritis - Product Status
Table 164: Diagnostic Test - Arthritis - Product Description
Table 165: University Rovira i Virgili Pipeline Products & Ongoing Clinical Trials Overview
Table 166: CD-Medics Test - RA - Product Status
Table 167: CD-Medics Test - RA - Product Description
Table 168: Glossary 112
LIST OF FIGURES
Figure 1: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Stage of Development
Figure 2: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Segment
Figure 3: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Territory
Figure 4: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Regulatory Path
Figure 5: Rheumatoid - Inflammatory Diseases Markers Tests - Pipeline Products by Estimated Approval
Date
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