Prof.
Eric Thiaudiere,
PhD
Born
1963, French
Personal Address
32 avenue des 2-ponts, F33600 Pessac, France
Laboratory Address : Magnetic Resonance Center, UMR5536, Case 93, CNRS-University Bordeaux-2,
146 rue Leo Saignat, F-33076 Bordeaux CEDEX
E-mail / Phone
thiaudiere@rmsb.u-bordeaux2.fr / +33 5 57 57 10 18
Current Position
France
University Professor in Biophysics, University Bordeaux Segalen, Bordeaux,
Recent
Positions
___________________________________________________________________________________
1992-2011
1991-1992 :
Assistant-Professor in Biophysics, University Bordeaux Segalen, France
Post-Doctoral research in EPFL Lausanne (Institute of Pysical-Chemistry #2)
Education
________________________________________________________________________________________
1987-1990
1986-1987
1983-1985
1981-1983
PhD in Physical Chemistry, University Bordeaux-1, France
M.Sc. ("DEA") in Physical Chemistry, University Bordeaux-1, France
B.Sc. and M.Sc. in Biochemistry, University Bordeaux-2, France
Higher education in Biological and Medical Analyses
Teaching
_________________________________________________________________________________________
Molecular Biophysics optical spectroscopy , NMR, application to structural biochemistry
Bio-imaging
MRI
Biochemistry
practical course in enzymology
Research
1986-1992
peptides
1992 -
______________________________________________________________________________________
Molecular Biophysics : Structure-Function relationships of membrane-bound
NMR of biological systems : spectroscopy of perfused organs and intact animal
and human
muscle, MRI method developments : fast 3D imaging, MR
angiography, cardiac MRI, in vivo Dynamic Nuclear Polarization
Peer-reviewed articles
Patent
69, h-index : 15 (Web-Of-Knowledge)
S. Miraux, E. Thiaudiere, P. Canioni and J. Franconi. "Description of a new MRI contrast based
on the use of chemical shift contrast agents." Patent WO2004062498 (2004).
List of Publications
1. J. Thevenot , H. de Oliveira, O. Sandre L. Pourtau, E. Andrés, S. Miraux, E. Thiaudière, E. Berra, S.
Lecommandoux. Multifunctional polymersomes for cancer theranostics. J Control Release.Nov
28;172(1):e44-5 (2013) .
2. G. Gouspillou, I. Bourdel-Marchasson, R. Rouland, G. Calmettes, M. Biran, V. Deschodt-Arsac, S.
Miraux, E. Thiaudiere, P. Pasdois, D. Detaille, J.M. Franconi, M. Babot, V. Trézéguet, L. Arsac, P.
Diolez. Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell. Aug 6. [Epub
ahead of print] (2013).
3. L. Pourtau, H. Oliveira, J. Thevenot, Y. Wan, A.R. Brisson, O. Sandre, S. Miraux, E. Thiaudiere, S.
Lecommandoux. Antibody-Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of
Bone Metastases using High Resolution MRI. Adv Healthc Mater. Apr 19. [Epub ahead of print] (2013).
4. E. Parzy, V. Bouchaud, P. Massot, P. Voisin, N. Koonjoo, D. Moncelet, J.M. Franconi, E. Thiaudiere,
and P. Mellet, Overhauser-enhanced MRI of elastase activity from in vitro human neutrophil
degranulation.PLoS One. 8(2): p. e57946 (2013).
5. H. Cochet, W. Lefrancois, M. Montaudon, F. Laurent, L. Pourtau, S. Miraux, E. Parzy, J.M. Franconi,
and E. Thiaudiere, Comprehensive phenotyping of salt-induced hypertensive heart disease in living
mice using cardiac magnetic resonance.Eur Radiol. 23(2): p. 332-8 (2013).
6. P. Massot, E. Parzy, L. Pourtau, P. Mellet, G. Madelin, S. Marque, J.M. Franconi, and E. Thiaudiere, In
vivo high-resolution 3D overhauser-enhanced MRI in mice at 0.2 T.Contrast Media Mol Imaging. 7(1):
p. 45-50 (2012).
7. L.M. Arsac, K. Nouette-Gaulain, S. Miraux, V. Deschodt-Arsac, R. Rossignol, E. Thiaudiere, and P.
Diolez, Acute and chronic effects of bupivacaine on muscle energetics during contraction in vivo: a
modular metabolic control analysis.Biochem J. 444(2): p. 315-21 (2012).
8. C. Sanson, O. Diou, J. Thevenot, E. Ibarboure, A. Soum, A. Brulet, S. Miraux, E. Thiaudiere, S. Tan, A.
Brisson, V. Dupuis, O. Sandre, and S. Lecommandoux, Doxorubicin Loaded Magnetic Polymersomes:
Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy.ACS Nano. 5(2): p. 1122-1140
(2011).
9. E.J. Ribot, S. Miraux, J.P. Konsman, V. Bouchaud, L. Pourtau, M.H. Delville, J.M. Franconi, E.
Thiaudiere, and P.J. Voisin, In vivo MR tracking of therapeutic microglia to a human glioma
model.NMR Biomed. 24(10): p. 1361-8 (2011).
10. W. Lefrancois, E. Thiaudiere, W. Ben Hassen, S. Sanchez, J.M. Franconi, and S. Miraux, Fast wholebody magnetic resonance angiography in mice.Magn Reson Med. 66(1): p. 32-9 (2011).
11. W. Lefrancois, S. Miraux, G. Calmettes, L. Pourtau, J.M. Franconi, P. Diolez, and E. Thiaudiere, A fast
black-blood sequence for four-dimensional cardiac manganese-enhanced MRI in mouse.NMR Biomed.
24(3): p. 291-8 (2011).
12. E.D. de La Roque, E. Thiaudiere, T. Ducret, R. Marthan, J.M. Franconi, C. Guibert, and E. Parzy,
Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiographytriggered three-dimensional time-resolved MR angiography.NMR Biomed. 24(3): p. 225-30 (2011).
13. E. Bled, W.B. Hassen, L. Pourtau, P. Mellet, T. Lanz, D. Schuler, P. Voisin, J.M. Franconi, E.
Thiaudiere, and S. Miraux, Real-time 3D MRI of contrast agents in whole living mice.Contrast Media
Mol Imaging (E-pub ahead of print). 6(4): p. 275-81 (2011).
14. V. Deschodt-Arsac, G. Calmettes, G. Gouspillou, R. Rouland, E. Thiaudiere, S. Miraux, J.M. Franconi,
and P. Diolez, System analysis of the effect of various drugs on cardiac contraction energetics.Biochem
Soc Trans. 38(5): p. 1319-21 (2010).
15. A. Dechamps, P. Diolez, E. Thiaudiere, A. Tulon, C. Onifade, T. Vuong, C. Helmer, and I. BourdelMarchasson, Effects of exercise programs to prevent decline in health-related quality of life in highly
deconditioned institutionalized elderly persons: a randomized controlled trial.Arch Intern Med. 170(2):
p. 162-9 (2010).
16. H. Cochet, M. Montaudon, F. Laurent, G. Calmettes, J.M. Franconi, S. Miraux, E. Thiaudiere, and E.
Parzy, In vivo MR angiography and velocity measurement in mice coronary arteries at 9.4 T: assessment
of coronary flow velocity reserve.Radiology. 254(2): p. 441-8 (2010).
17. G. Calmettes, V. Deschodt-Arsac, G. Gouspillou, S. Miraux, B. Muller, J.M. Franconi, E. Thiaudiere,
and P. Diolez, Improved energy supply regulation in chronic hypoxic mouse counteracts hypoxiainduced altered cardiac energetics.PLoS One. 5(2): p. e9306 (2010).
18. E.J. Ribot, S. Miraux, M.H. Delville, V. Bouchaud, S. Lacomme, E. Gontier, A.K. Bouzier-Sore, J.M.
Franconi, E. Thiaudiere, and P. Voisin, Study of the MR relaxation of microglia cells labeled with GdDTPA-bearing nanoparticles.Contrast Media Mol Imaging. 4(3): p. 109-17 (2009).
19. E. Parzy, S. Miraux, J.M. Franconi, and E. Thiaudiere, In vivo quantification of blood velocity in
mouse carotid and pulmonary arteries by ECG-triggered 3D time-resolved magnetic resonance
angiography.NMR Biomed. 22(5): p. 532-7 (2009).
20. S. Miraux, G. Calmettes, P. Massot, W. Lefrancois, E. Parzy, B. Muller, L.M. Arsac, V. Deschodt-Arsac,
J.M. Franconi, P. Diolez, and E. Thiaudiere, 4D retrospective black blood trueFISP imaging of mouse
heart.Magn Reson Med. 62(5): p. 1099-105 (2009).
21. P. Mellet, P. Massot, G. Madelin, S.R.A. Marque, E. Harte, J.M. Franconi, and E. Thiaudiere, New
Concepts in Molecular Imaging: Non-Invasive MRI Spotting of Proteolysis Using an Overhauser Effect
Switch. PLoS ONE. 4(4): p. e5244 (2009).
22. L. Malaval, L. Monfoulet, T. Fabre, L. Pothuaud, R. Bareille, S. Miraux, E. Thiaudiere, G. Raffard, J.M.
Franconi, M.H. Lafage-Proust, J.E. Aubin, L. Vico, and J. Amedee, Absence of bone sialoprotein (BSP)
impairs cortical defect repair in mouse long bone.Bone 45(5):853-61 (2009).
23. C. Beuste, S. Miraux, V.J. Deschodt-Arsac, E. Thiaudiere, J.M. Franconi, P. Diolez, and L.M. Arsac,
Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal
muscle in vivo.Biochem J. 420(1): p. 67-72 (2009).
24. E.J. Ribot, E. Thiaudiere, R. Roulland, P. Brugieres, A. Rahmouni, P. Voisin, J.M. Franconi, and S.
Miraux, Application of MRI phase-difference mapping to assessment of vascular concentrations of BMS
agent in mice.Contrast Media Mol Imaging. 3(2): p. 53-60 (2008).
25. S. Miraux, P. Massot, E.J. Ribot, J.M. Franconi, and E. Thiaudiere, 3D TrueFISP imaging of mouse
brain at 4.7T and 9.4T.J Magn Reson Imaging. 28(2): p. 497-503 (2008).
26. G. Calmettes, V. Deschodt-Arsac, E. Thiaudiere, B. Muller, and P. Diolez, Modular control analysis
(MoCA) of the effects of chronic hypoxia on mouse heart.Am J Physiol Regul Integr Comp Physiol,
(2008).
27. L.M. Arsac, C. Beuste, S. Miraux, V. Deschodt-Arsac, E. Thiaudiere, J.M. Franconi, and P.H. Diolez, In
vivo modular control analysis of energy metabolism in contracting skeletal muscle.Biochem J. 414(3): p.
391-7 (2008).
28. P. Voisin, E.J. Ribot, S. Miraux, A.K. Bouzier-Sore, J.F. Lahitte, V. Bouchaud, S. Mornet, E.
Thiaudiere, J.M. Franconi, L. Raison, C. Labrugere, and M.H. Delville, Use of lanthanide-grafted
inorganic nanoparticles as effective contrast agents for cellular uptake imaging.Bioconjug Chem. 18(4):
p. 1053-63 (2007).
29. E. Parzy, Y. Fromes, E. Thiaudiere, and P.G. Carlier, Refinement of cardiac NMR imaging in awake
hamsters: proof of feasibility and characterization of cardiomyopathy.NMR Biomed. 20(6): p. 615-23
(2007).
30. P. Diolez, V. Deschodt-Arsac, G. Raffard, C. Simon, P.D. Santos, E. Thiaudiere, L. Arsac, and J.M.
Franconi, Modular regulation analysis of heart contraction: application to in situ demonstration of a
direct mitochondrial activation by calcium in beating heart.Am J Physiol Regul Integr Comp Physiol.
293(1): p. R13-9 (2007).
31. I. Bourdel-Marchasson, M. Biran, P. Dehail, T. Traissac, F. Muller, J. Jenn, G. Raffard, J.M. Franconi,
and E. Thiaudiere, Muscle phosphocreatine post-exercise recovery rate is related to functional
evaluation in hospitalized and community-living older people.J Nutr Health Aging. 11(3): p. 215-21
(2007).
32. V. Aguilar, S. Alliouachene, A. Sotiropoulos, A. Sobering, Y. Athea, F. Djouadi, S. Miraux, E.
Thiaudiere, M. Foretz, B. Viollet, P. Diolez, J. Bastin, P. Benit, P. Rustin, D. Carling, M. Sandri, R.
Ventura-Clapier, and M. Pende, S6 kinase deletion suppresses muscle growth adaptations to nutrient
availability by activating AMP kinase.Cell Metab. 5(6): p. 476-87 (2007).
33. S. Miraux, J.M. Franconi, and E. Thiaudiere, Blood velocity assessment using 3D bright-blood timeresolved magnetic resonance angiography.Magn Reson Med. 56(3): p. 469-73 (2006).
34. G. Madelin, D. Grucker, J.M. Franconi, and E. Thiaudiere, Magnetic resonance imaging of acoustic
streaming: absorption coefficient and acoustic field shape estimation.Ultrasonics. 44(3): p. 272-8
(2006).
35. M. Lederlin, E. Thiaudiere, F. Laurent, J.M. Franconi, and E. Parzy, In vivo MR imaging of pulmonary
arteries of normal and experimental emboli in small animals.J Magn Reson Imaging. 24(6): p. 1298-302
(2006).
36. S. Miraux, G. Raffard, L. Pothuaud, L. de Taillac, J. Amédée, P. Canioni, E. Thiaudiere, and J.M.
Franconi, NMR Microscopy with a High-Resolution Liquid-State Spectroscopy Probe.Concepts in
Magnetic Resonance Part B (Magnetic Resonance Engineering). 25B: p. 12-17 (2005).
37. G. Madelin, B. Hosten, C. Biateau, C. Mougenot, J.M. Franconi, and E. Thiaudiere, Comparison of
laser interferometry and radiation force method of measuring ultrasonic power.Ultrasonics. 43: p. 76974 (2005).
38. Klinkosz, C.J. Lewa, G. Madelin, and E. Thiaudiere, A theoretical approach to local attenuation
measurements of shear waves by MRE. Preliminary experimental results.Central European Journal of
Physics. 3: p. 420-432 (2005).
39. S. Miraux, E. Thiaudiere, P. Canioni, and J.M. Franconi, Magnetization recovery for signal
enhancement: a fast imaging DEFT-based technique. J. Magn. Reson.166: p. 28-34 (2004).
40. S. Miraux, S. Serres, E. Thiaudiere, P. Canioni, M. Merle, and J. Franconi, Gadolinium-enhanced
small-animal TOF magnetic resonance angiography.MAGMA. 17: p. 348-52 (2004).
41. S. Miraux, S. Lemiere, R. Pineau, M. Pluderi, P. Canioni, J.M. Franconi, E. Thaudiere, L. Bello, A.
Bikfalvi, and P. Auguste, Inhibition of FGF Receptor Activity in Glioma Implanted into the Mouse Brain
using the Tetracyclin-Regulated Expression System.Angiogenesis. 7: p. 105-113 (2004).
42. L.M. Arsac, E. Thiaudiere, P. Diolez, and L. Gerville-Reache, Parameter estimation in modeling
phosphocreatine recovery in human skeletal muscle.Eur. J. Appl. Physiol.91: p. 419-424 (2004).
43. G. Madelin, N. Baril, C.J. Lewa, J.M. Franconi, P. Canioni, E. Thiaudiere, and J.D. de Certaines,
Detection of acoustic waves by NMR using a radiofrequency field gradient.J. Magn. Reson.16: p. 108111 (2003).
44. R.J. Yquel, L.M. Arsac, E. Thiaudiere, P. Canioni, and G. Manier, Effect of creatine supplementation on
phosphocreatine resynthesis, inorganic phosphate accumulation and pH during intermittent maximal
exercise.J Sports Sci. 20(5): p. 427-37. (2002).
45. E. Couplan, C. Gelly, M. Goubern, C. Fleury, B. Quesson, M. Silberberg, E. Thiaudiere, P. Mateo, M.
Lonchampt, N. Levens, C. de Montrion, S. Ortmann, M.D. Gonzalez-Barroso, A.M. Cassard-Doulcier,
D. Ricquier, X. Bigard, P. Diolez, and B. F., High level of UCP1 expression in muscle of transgenic mice
selectively affects muscles at rest and decreases their IIb fiber content. J. Biol. Chem.45: p. 43079-88
(2002).
46. N. Baril, C.J. Lewa, J.D. de Certaines, P. Canioni, J.M. Franconi, and E. Thiaudiere, MR detection of
mechanical vibrations using a radiofrequency field gradient.J. Magn. Reson.154: p. 22-27 (2002).
47. J.C. Talbot, E. Thiaudiere, M. Vincent, J. Gallay, O. Siffert, and J. Dufourcq, Dynamics and orientation
of amphipathic peptides in solution and bound to membranes : a steady-state and time-resolved
fluorescence study of staphylococcal d-toxin and its synthetic analogues. Eur. Biophys. J.30: p. 147-161
(2001).
48. C.J. Lewa, N. Baril, J.M. Franconi, J.D. De Certaines, P. P. Canioni, and E. Thiaudiere, Detection of
mechanical vibration by Magnetic Resonance; Elasto-Magnetic Resonance Spectroscopy
(EMRS).Acousto-Optics Appl. SPIE. 4514: p. 201-210 (2001).
49. J.F. Chateil, . Biran, E.Thiaudiere, . Canioni, and . Merle, of [1-13C]glucose and [2-13C]acetate on the
hypoxic rat brain. . Int. 38: p. 399-407 (2001).
50. I. Bourdel-Marchasson, P.-A. Joseph, P. Dehail, M. Biran, P. Faux, M. Rainfray, J.-P. Emeriau, P.
Canioni, and E. Thiaudiere, Functional and matabolic changes in calf muscle occuring during
nutritional repletion in malnourished elderly patients.Am. J. Clin. Nutr.73: p. 821-826 (2001).
51. G. Vidal, E. Thiaudiere, P. Canioni, and J.L. Gallis, Aminomethylphosphonate and 2aminoethylphosphonate as 31P-NMR pH markers for extracellular and cytosolic spaces in the isolated
perfused rat liver.NMR Biomed.13: p. 289-296 (2000).
52. M.C. Delmas-Beauvieux, N. Leducq, E. Thiaudiere, P. Diolez, H. Gin, P. Canioni, and J.L. Gallis,
Liposomes as fatty acids carriers in isolated rat liver: effect on energy metabolism and on isolated
mitochondria activity.MAGMA. 10: p. 43-51 (2000).
53. A.K. Bouzier, E. Thiaudiere, M. Biran, R. Rouland, P. Canioni, and M. Merle, The metabolism of [313C]Lactate in the rat brain is specific of a pyruvate carboxylase-deprived compartment.J.
Neurochem.75: p. 480-486 (2000).
54. N. Baril, E. Thiaudiere, B. Quesson, C. Delalande, P. Canioni, and J.M. Franconi, Single coil surface
imaging using a radio-frequency field gradient.J. Magn. Reson.146: p. 223-227 (2000).
55. V. Dousset, C. Delalande, L. Ballarino, B. Quesson, D. Seilhan, M. Coussemacq, E. Thiaudiere, B.
Brochet, P. Canioni, and J.M. Caille, In vivo macrophage activity imaging in the central nervous system
detected by magnetic resonance.Magn Reson Med. 41(2): p. 329-33 (1999).
56. M.C. Delmas-Beauvieux, B. Quesson, E. Thiaudiere, J.L. Gallis, P. Canioni, and H. Gin, 13C nuclear
magnetic resonance study of glycogen resynthesis in muscle after glycogen-depleting exercise in healthy
men receiving an infusion of lipid emulsion.Diabetes. 48(2): p. 327-33 (1999).
57. J.F. Chateil, B. Quesson, M. Brun, E. Thiaudiere, J. Sarlangue, C. Delalande, C. Billeaud, P. Canioni,
and F. Diard, Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a
preliminary report.Pediatr Radiol. 29(3): p. 199-205 (1999).
58. B. Quesson, E. Thiaudiere, C. Delalande, J.F. Chateil, C.T.W. Moonen, and P. Canioni, Magnetization
transfer imaging of rat brain under non-steady-state conditions. Contrast prediction using a binary spinbath model and a super-lorentzian lineshape.J Magn Reson. 130(2): p. 321-8 (1998).
59. B. Quesson, E. Thiaudiere, C. Delalande, V. Dousset, J.F. Chateil, and P. Canioni, Magnetization
transfer imaging in vivo of the rat brain at 4.7 T: interpretation using a binary spin-bath model with a
superLorentzian lineshape.Magn Reson Med. 38(6): p. 974-80 (1997).
60. B. Quesson, A.K. Bouzier, E. Thiaudiere, C. Delalande, M. Merle, and P. Canioni, Magnetization
transfer fast imaging of implanted glioma in the rat brain at 4.7 T: interpretation using a binary spin-bath
model.J Magn Reson Imaging. 7(6): p. 1076-83 (1997).
61. S. Dufour, E. Thiaudiere, G. Vidal, J.L. Gallis, N. Rousse, and P. Canioni, Temperature dependence of
NMR relaxation times of nucleoside triphosphates and inorganic phosphate in the isolated perfused rat
liver. Effect on Pi compartmentation.J Magn Reson B. 113(2): p. 125-35 (1996).
62. I. Bourdel-Marchasson, M. Biran, E. Thiaudiere, C. Delalande, A. Decamps, G. Manciet, and P.
Canioni, 31P magnetic resonance spectroscopy of human liver in elderly patients: changes according to
nutritional status and inflammatory state.Metabolism. 45(9): p. 1059-61 (1996).
63. E. Thiaudiere, M. Biran, C. Delalande, B. Bouligand, and P. Canioni, In vivocarbon-13 chemical shift
imaging of the human liver. Magnetic Resonance Materials Physics Biol. Med.2: p. 425-428 (1994).
64. E. Thiaudiere, M. Soekarjo, E. Kuchinka, A. Kuhn, and H. Vogel, Structural characterization of
membrane insertion of M13 Procoat, P13 Coat and Pf3 Coat Proteins. Biochemistry. 32(45): p. 1218712196 (1993).
65. E. Thiaudiere, J.L. Gallis, S. Dufour, N. Rousse, and P. Canioni, Compartmentation of inorganic
phosphate in perfused rat liver. Can cytosol be distinguished from mitochondria by 31P NMR? FEBS
Lett. 330(2): p. 231-5 (1993).
66. J. Dufourcq, E.J. Dufourc, J.C. Maillet, I. Cornut, and E. Thiaudiere, Peptide-induced changes in
structure, dynamic and barrier properties of liposomes and membranes. Phosphorus, Sulfur, Silicon. 77:
p. 113-116 (1993).
67. E. Thiaudiere, O. Siffert, J.C. Talbot, J. Bolard, J.E. Alouf, and J. Dufourcq, The amphiphilic alphahelix concept. Consequences on the structure of staphylococcal delta-toxin in solution and bound to
lipids.Eur J Biochem. 195(1): p. 203-13 (1991).
68. E. Perez-Paya, E. Thiaudiere, C. Abad, and J. Dufourcq, Selective labelling of melittin with a
fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase.FEBS Lett. 278(1): p. 51-4
(1991).
69. J.E. Alouf, J. Dufourcq, O. Siffert, E. Thiaudiere, and C. Geoffroy, Interaction of staphylococcal deltatoxin and synthetic analogues with erythrocytes and phospholipid vesicles. Biological and physical
properties of the amphipathic peptides.Eur J Biochem. 183(2): p. 381-90 (1989).