GRADUATE STUDENT RESEARCH INTERESTS
Liu, Tuoen
My
research
interest
focuses
on
cancer
biology
specifically
in
the
field
of
drug
resistant
and
hematological
malignancies.
My
dissertation
research
is
titled
as
“investigations
into
the
multiple
role
of
HSPa8
gene/HSC70
in
regulation
of
cancer
cellular
phenotype”.
I
am
studying
the
role
of
HSPa8
gene
which
codes
for
the
heat
shock
cognate
70
(HSC70)
protein.
HSPa8/HSC70
may
play
a
role
in
regulating
the
cross
resistance
of
multiple
anti‐cancer
drugs,
Methotrexate
(MTX)
and
Cisplatin
(DDP)
in
the
L1210
murine
leukemia
cell
lines.
This
may
be
a
novel
mechanism
for
drug
resistance
in
chemotherapy
of
neoplastic
diseases.
The
methods
and
technologies
used
in
my
current
research
include
MTT,
Western
Blotting,
TUNEL
Assay,
RT‐PCR,
Gene
Clone,
MTX
agarose
binding
assay.
Pandit,
Meghana:
I
am
currently
working
in
Dr.John
Eley's
laboratory
and
am
mainly
interested
in
drug
delivery
and
drug
transport.The
projects
that
I
am
working
on
are:
1)
Co‐culture
of
endothelial
cells
and
astrocytes
as
an
in
vitro
model
of
the
blood‐brain
barrier.
2)
Preparation
and
evaluation
of
polymeric
nanoparticles
containing
Insulin‐Like
Growth
Factor‐II(IGF‐II).
3)
Transport
of
IGF‐II
nanoparticles
and
conventional
anti‐cancer
drugs
across
the
prepared
in
vitro
model
of
the
blood‐brain
barrier.
Larkin, John: Investigates the role of sex steroids and fertility parameters in brain-mediated
stress responses induced by intracerebroventricular alcohol.
Li, Yu: Determining the function of catecholamines in HPA responses to alcohol.
Veerubhotla, Ram Sunil:
I am doing my master's degree in pharmaceutics and research interests are in development of
drug formulations, particle characterization, dissolution testing,thermogravimetric analysis
(TGA),and biopharmaceutical analysis.I am currently working on three projects.
1.Development of oral drug delivery system for delivery of plasmid in rainbow trout fish.
2.preparing suppositories loaded with hydrocodone suppositories.
3.Preparation of solid lipid nanoparticles as a drug delivery system to reduce the side effects of
conventional anticancer drugs.
Bhardwaj,
Vikas:
Currently
I
am
working
on
elucidating
the
mechanisms
involved
in
pancreatic
cancer
resistance
and
use
of
natural
compounds
for
reversing
it.
Chatterji,
Tanushree:
My
research
deals
with
studying
the
metabolic
adaption
for
survival
occurring
in
the
glial
cancer
cells
and
the
shift
between
the
metabolic
pathways
for
energy
production
in
a
glial
cancer
cell.
I
am
also
looking
into
the
differences
in
the
astrocytoma
and
the
neuroblastoma
cells
metabolically
with
the
help
of
various
glycolytic
inhibitors.
Vishwasrao,
Hemant:
I
am
working
on
development
of
nanoparticulate
drug
delivery
systems
for
sustained
and
control
release
with
special
emphasis
on
combination
therapy.
regards,
Jandhyam,
Sirisha:
Nanotoxicology
and
Nanopharmacology
of
metallic
oxide
nanoparticles.
Dukhande,
Vikas:
We
are
looking
at
the
mechanism
of
neuronal
death
due
to
glutathione
depletion‐induced
oxidative
stress.
This
is
implicated
in
Parkinson's
disease,
Alzheimer's
disease
and
stroke.
Gangavarapu,
Kalyan:
My
research
focuses
on
investigating
signaling
mechanisms
responsible
for
dexamethasone
resistance
in
7TD1
cells,
a
mouse
multiple
myeloma
model
system.
Sehdev,
Vikas:
Our
primary
research
interest
is
to
determine
the
molecular
mechanisms
underlying
the
anticancer
properties
of
isoflavones.
We
are
probing
the
effect
of
isoflavones
on
growth
promoting,
survival
and
invasive
signal
transduction
pathways
in
HER‐2
positive
breast
cancer
cells.
Our
research
indicates
that
isoflavones
are
a
unique
group
of
natural
compounds
which
can
target
signaling
pathways
regulating
growth,
survival
and
invasion
of
HER‐2
positive
breast
cancer
cells.
Rizvi,
Nisha:
We
are
involved
in
the
area
of
molecular
and
metabolic
mechanisms
underlying
neurodegeneration.
Our
studies
include
elucidation
of
mechanisms
related
to
inflammatory
processes
occurring
in
neurodegenerative
conditions
like
Alzheimer’s
disease,
Parkinson’s
disease
and
Amyotropic
lateral
sclerosis
(ALS).
We
are
looking
at
a
nuclear
receptor
PPARγ
as
a
potential
target
for
combating
inflammation
and
neuronal
cell
death
by
using
the
glitazones
currently
being
used
as
therapy
for
Type
II
Diabetes
mellitus.
Recently
Graduated
Students
Vrushali
Arvind
Agharkar:
In
vitro
cellular
toxicity
of
carbon
nanotubes"
Ashwini
Saini:
My
research
interest
is
the
characteristaion
of
methotrexate
binding
protein
in
a
mouse
leukemia
L1210
cell
line
and
investigating
its
role
in
methotrexate
resistance.
Gangavarapu,
Kalyan:
My
research
focuses
on
investigating
signaling
mechanisms
responsible
for
dexamethasone
resistance
in
7TD1
cells,
a
mouse
multiple
myeloma
model
system.