Innovation in Biologics
Automating the process workflow
for greater productivity
• NEW TripleTOF® 6600 System
• NEW SWATH™ Acquisition 2.0
• NEW BioPharmaView™ Software
AB SCIEX has turned its pharmaceutical expertise and
It all starts here
application insight into a leadership biologics solution
Introducing the AB SCIEX TripleTOF® 6600 System
for the future – that you can have today.
The TripleTOF® 6600 delivers the exceptional performance
and resolution required to meet the most demanding
challenges in biologics:
From development and concurrent bioanalysis through
production, greater automation now reduces complexity
and lets you confidently analyze more data at
a deeper level, faster than before.
• U
p to 5 orders of linear dynamic range
Demonstrate intact molecular weight of protein
theraputics, from development to process optimization
• E
xtended Q1 mass range for ions up to 2250 m/z
Provides excellent peptide profiling and signatures
• S
uperior mass resolution, mass accuracy and stability
At < 2 ppm RMS, consistently captures more low density
ions for deeper knowledge
Finding the perfect balance
The right combination is just as important when
building a biologics solution as it is when discovering
a breakthrough biotherapeutic.
BioPharmaView™
Software
SWATH™
Acquisition 2.0
Software
TripleTOF® 6600 System
Enhanced automation with BioPharmaView
Nothing hides from SWATH
™
Setting a new standard for biologics data processing
Manual methods are simply unable
to keep up with the complexity of
processing bulk data for large
molecules: enhanced data accuracy,
integration and report generation are absolute
requirements in biologics.
BioPharmaView™ Software offers a powerful
new solution for automating core workflows. It
incorporates exceptional investigative capabilities,
enables faster method development and provides
excellent change control monitoring.
™
See more, much more clearly on the TripleTOF® 6600
AB SCIEX TripleTOF® Systems with
BioPharmaView™ Software deliver
accurate assay information for protein
sequencing, alkylation and digest.
The TripleTOF® 6600 with SWATH™ 2.0
captures every detectable peptide in a
single injection. You’re assured of catching
the smallest contaminant for sensitive
quantitation. Whether you’re performing intact mass
analysis or host cell protein analysis, SWATH™ enables you
to obtain higher quality data with greater confidence.
SWATH™ 2.0 with variable windows lets you see low
abundance peptides that you might miss otherwise,
offering excellent specificity and reproducibility for a
better understanding of the biotherapeutic.
utomate core workflows for intact protein
A
and peptide analysis
• Detect and quantitate variations
• Flag out-of-specification conditions for follow-up
• Initiate batch processing and report generation
In addition, the results from every run can be digitally
archived and re-examined at will to meet quality and
regulatory requirements as needed.
BioPharmaView™ automates intact mass analysis
and peptide mapping, and offers customizable
The TripleTOF® 6600 with SWATH 2.0 delivers a dynamic range up to 5 orders,
Assay Information
capturing valuable low abundance isoforms other methods miss.
report generation.
Mass Accuracy for Both High and Low Abundant Species
Characterize Standard
Bivalirudin Metabolite
C55H77N9O19
Intensity- 3e2
Mass accuracy – 2.6 ppm
30,000 FWHM
3.5e6
Batch Process
3.0e6
*584.7756 (2)
585.2756 (2)
300
Review Results
Generate Report
Intensity
2.5e6
2.0e6
Intensity
250
200
1.0e6
0.5e6
0.0e6
*727.3369 (3)
150
Bivalirudin�C98H137N24O33
Intensity-3.6e6
Mass accuracy – 1.5 ppm
37,000 FWHM
100
50
0
1.5e6
*1090.5018 (2)
1091.0062 (2)
570
575
580
585
590
Mass/Charge, Da
Mass Accuracy
High Resolution
Wide Dynamic Range
At Fast Acquisition Rates
200
300
595
1091.5036 (2)
727.6716 (3)
600
728.0053 (3)
1092.0045 (2)
734.9980 (3)
400
500
600
700
Mass/Charge, Da
*734.6634 (3)
800
1101.9926 (2)
900
1000
1100
1200
Your success is our success
We take it personally
As an AB SCIEX customer you have access to a world-class customer support organization.
Wherever you are, we’re there with you as a trusted partner to answer questions, provide
solutions, and maximize lab productivity.
Our customer support organization has access to the latest product updates, software
revisions, methods and repair procedures to make sure that you stay on top of your game.
When you have questions, we have answers.
Learn more about our support options at www.absciex.com/customersupport, or locate
your local account representative at www.absciex.com/contactus
See our entire suite of solutions for Biologics research at www.absciex.com/biologics
For Research Use Only. Not for use in diagnostic procedures.
© 2014 AB SCIEX. The trademarks mentioned herein are the property of
AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used
under license.
10280114-01 RUO-MKT-07-1484-A 06/2014
Headquarters
500 Old Connecticut Path
Framingham, MA 01701 USA
Phone 508-383-7700
www.absciex.com
International Sales
For our office locations please call the division
headquarters or refer to our website at
www.absciex.com/offices