Technical Information – Quickstart
EUDRAGIT® RL 30 D/RS 30 D
Sustained-release with talc as anti-tacking agent
Formulation
The following formulation is calculated for a standard quantity of 1 kg spray suspension. The quantity for film coating of your substrate depends on
the application and surface area of the substrate. Please contact us if you need assistance to calculate your individual formulation.
Quantity based on
dry polymer [%]
Quantity to be
weighed [g]
Function
Ingredient
Polymer
EUDRAGIT® RL 30 D (1 part)
Dry substance [g]
Polymer
EUDRAGIT® RS 30 D (9 parts)
Plasticizer
Triethyl citrate
20.0
23.5
23.5
Anti-tacking
Talc
50.0
58.8
58.8
Diluent
Water
39.3
11.8
352.9
105.9
525.5
Total
1000.0
200.0
Excipient suspension
Talc and triethyl citrate are homogenized in water using a homogenizer
(e.g. Ultra Turrax) for 10 minutes.
Talc
Triethyl citrate
55
0
50
Antifoam
agent*
Water
10
45
40
35
5
15
30
20
25
* If necessary, add a small quantity of an
antifoam agent (e.g. simethicone emulsion)
Spray suspension
Pour the excipient suspension slowly into
the EUDRAGIT® dispersion while stirring
gently with a conventional stirrer.
Pass the spray suspension through a
0.5 mm sieve.
Excipient
suspension
EUDRAGIT® dispersion
Spray suspension
(should be stirred continuously)
Coating parameters:
The tables below give examples of process parameters for film coating. Please do not hesitate to contact us if you need
assistance to find the right parameters for your specific equipment, batch size, and substrate combination.
EUDRAGIT® RL 30 D/RS 30 D on particles (1 kg) in Glatt GPCG 1.1, top spray
Equipment setup
Nozzle bore
mm
1.2
Distance nozzle/product
cm
10
Internal silicone tube diameter
mm
2
Atomizing air pressure
bar
2.0
Filter rattling time
s
5
Filter rattling interval
s
45
Drying air volume
m³/h
45 –90
Drying air capacity
m³/min/kg
0.75 –1.5
Inlet air temperature
°C
35 –50
Exhaust air temperature
°C
25 –30
Product temperature
°C
25 –30
Spray rate
g/min/kg
8 –12
Inlet air temperature
°C
20 –55
Drying air capacity
m3/min/kg
1.2 –1.7
Exhaust air temperature
°C
30 –50
Product temperature
°C
45 –50
Exhaust air humidity
% r.h.
10 –15
Water spray rate
ml/kg
240
Spraying time
min
30
Process parameter setup
Process data
In process curing
® = registered trademark EUDRAGIT is a registered trademark of Evonik Röhm GmbH, Darmstadt, Germany.
Evonik Industries AG
Kirschenallee, 64293 Darmstadt, Germany
eudragit@evonik.com www.eudragit.com www.eudragit.com/e-lab www.evonik.com
Dec 2011, V 3.0
This information and all further technical advice is based on our present knowledge and experience. However, it implies no liability or other legal responsibility on our part, also with regard to existing third party intellectual property rights, especially patent rights. In particular, no warranty, whether express or
implied, or guarantee of product properties in the legal sense is intended or implied. We reserve the right to make any changes according to technological
progress or further developments. The customer is not released from the obligation to conduct careful inspection and testing of incoming goods.
Performance of the product described herein should be verified by testing, which should be carried out only by qualified experts in the sole responsibility
of a customer. Reference to trade names used by other companies is neither a recommendation, nor does it imply that similar products could not be used.