Chapter 3 Anatomy for Nutrition’s Sake 2010 Cengage-Wadsworth Introduction to the Human Body • The body is composed of millions of cells. • Each cell is a selfcontained living entity. • The body cells need: Energy (or fuel) Oxygen Water Nutrients • Cells: the smallest units in which independent life can exist. All living things are single cells or organisms made of cells. 2010 Cengage-Wadsworth Introduction to the Human Body A typical cell 2010 Cengage-Wadsworth A membrane encloses each cell’s contents. A separate inner membrane encloses the cell’s nucleus. These fingerlike projections are typical of cells that absorb nutrients in the intestines. Inside the nucleus, the Genetic material, DNA, contains the genes. The genes control the inheritance of the cell’s characteristics and its dayto-day workings. The DNA is faithfully copied each time the cell duplicates itself. On these membranes, instructions from the genes are translated into proteins that perform functions in the body. Many other structures are present. This is a mitochondrion, a structure that takes in nutrients and releases energy from them. Fig. 3-1, p. 76 Introduction to the Human Body • Cells are organized into tissues designed to perform specialized tasks. Some of these tasks include the formation of muscles and organs. • Several organs work cooperatively to form a body system. The digestive system consists of organs and tissues working together to supply energy, water, and essential nutrients to every body cell. 2010 Cengage-Wadsworth Digestive System • Hypothalamus: The hypothalamus monitors the body’s conditions & sends signals to the brain’s thinking portion, the cortex, which decides on actions. Detects fuel deprivation Generates nerve impulses that signal hunger to the conscious part of the brain 2010 Cengage-Wadsworth Cortex Hypothalamus Spinal cord Fig. 3-2, p. 77 Digestive System • The gastrointestinal (GI) tract supplies the body with a constant supply of water and nutrients by controlling: Passage of food through GI tract Secretion of digestive juices and enzymes Digestion of food Absorption of water and nutrients Circulating blood through digestive system to distribute absorbed substances 2010 Cengage-Wadsworth Digestive System •Each part of the digestive tract has specific functions such as: Basic passage of food Temporary storage unit Digest food Absorb food The digestive system 2010 Cengage-Wadsworth 2010 Cengage-Wadsworth Salivary glands Esophagus Stomach Liver Mouth Tongue Airway to lungs Gallbladder Pancreas Pancreatic duct Pyloric sphincter Bile duct Colon (large intestine) Small intestine Appendix Rectum Anus Fig. 3-3a, p. 78 2010 Cengage-Wadsworth The Mouth • Digestive process begins in the mouth through mechanical digestion (physically breaking down foods). Breaks down indigestible membranes and uncovers nutrient-rich portion of foods. Exposes surface area of food to digestive enzymes. Contains salivary glands which secrete digestive enzymes and help to moisten food and make it easier to swallow. 2010 Cengage-Wadsworth Oropharyngeal stage of swallowing 2010 Cengage-Wadsworth Nasal passages Hard palate Soft palate Uvula Pharynx Epiglottis Esophagus Bolus Trachea Tongue Glottis at entrance of larynx Fig. 3-6a, p. 81 Swallowing center inhibits respiratory center in brain stem Elevation of uvula prevents food from entering nasal passages Position of tongue prevents food from re-entering mouth Epiglottis is pressed down over closed glottis as auxiliary mechanism to prevent food from entering airways Tight apposition of vocal folds across glottis prevents food from entering respiratory airways (viewed from above) Fig. 3-6b, p. 81 The Mouth • When food is chewed the mixture of food particles and saliva is called a bolus. • The bolus moves from the mouth to the esophagus through swallowing. The first part of swallowing which moves food toward the pharynx is voluntary. After food reaches the pharynx, swallowing is considered to be involuntary and cannot be stopped. The trachea (windpipe) closes and the pharynx propels the bolus toward the esophagus. 2010 Cengage-Wadsworth The Esophagus • No digestion takes place in the esophagus. • Food passes from the mouth to the stomach and travels through the esophagus. • Sphincters open and close to allow the bolus to pass. Sphincter: a circular band of muscle fibers that constrict a passage or close a natural opening in the body. • Peristalsis: Longitudinal and circular muscle layers of the esophagus rhythmically push the bolus down the esophagus. 2010 Cengage-Wadsworth The Stomach • Three jobs of the stomach: Stores food until it can be processed. Forms chyme: the semi-liquid blend of food and gastric secretions that forms in the stomach during digestion. Controls movement of chyme into the small intestine at a rate suitable for digestion and absorption by the small intestine. • An empty stomach holds about 3 tablespoons but can stretch to about one liter for holding food and drinks. 2010 Cengage-Wadsworth The Stomach •Food passes through the gastroesophageal sphincter to enter the stomach. •Peristalsis causes the stomach to churn, mixing the food with hydrochloric acid (HCL) and gastric secretions to form chyme. •The pyloric sphincter controls the emptying of the stomach. Anatomy of the stomach 2010 Cengage-Wadsworth Esophagus Gastroesophageal sphincter Pyloric sphincter Smooth muscle Stomach folds Duodenum Fig. 3-7, p. 83 The Stomach Mixing of stomach contents and emptying of the stomach 2010 Cengage-Wadsworth Stomach Esophagus 1 Gastroesophageal sphincter Pyloric sphincter Duodenum 4 3 2 Movement of chyme Peristaltic contraction Gastric emptying Direction of movement of peristaltic contraction 6 5 Peristaltic contraction Gastric mixing Fig. 3-8, p. 84 The Stomach • The stomach empties in about four hours. Liquids pass the quickest. Solids stay until mixed with stomach secretions. Carbohydrate passes more quickly than protein. Fat takes the longest to digest. • The rate of emptying is controlled by the central nervous system (CNS) and hormonal mechanisms. 2010 Cengage-Wadsworth Digestive Tract Secretions 2010 Cengage-Wadsworth The Small Intestine • The small intestine is about 20 feet in length. • It is smaller in diameter than the large intestine, thus the name “small” intestine. • It finishes the job of digestion and absorption of nutrients. 2010 Cengage-Wadsworth The Small Intestine • Chyme must touch the walls to make contact with secretions and be absorbed at the proper places. • Peristalsis moves chyme through the small intestine. Stimulated by fiber Slowed by fat • The ileocecal valve controls the flow of contents going into the large intestine. 2010 Cengage-Wadsworth The Small Intestine • The small intestine works to break down food and nutrients to their smallest absorbable components. • This breakdown is complex, requiring many chemical reactions: Hormonal messages tell the gallbladder to send its emulsifier, bile. Hormones send messages to the pancreas to release the neutralizer, bicarbonate. Pancreatic and intestinal enzymes act to break bonds of larger nutrients. 2010 Cengage-Wadsworth The Small Intestine Bile: a compound made from cholesterol by the liver, stored in the gallbladder, and secreted into the small intestine. It emulsifies lipids to ready them for enzymatic digestion. Emulsifier: a compound with both water-soluble and fat-soluble portions that can attract lipids into water to form an emulsion. 2010 Cengage-Wadsworth The Small Intestine • After breakdown, these nutrient components are able to cross through the absorptive cells lining the small intestine and enter the blood and lymph supply. • These cells are selective and efficient as they absorb enough nutrients to nourish all the body’s other cells. 2010 Cengage-Wadsworth The Small Intestine • The intestinal tract lining contains an enormous absorbing surface. Villi: fingerlike projections of the sheet of cells that line the GI tract; the villi make the surface area much greater than it would otherwise be. Microvilli: tiny hairlike projections on each cell of the intestinal tract lining that can trap nutrient particles and translocate them into the cells. 2010 Cengage-Wadsworth Details of the lining of the small intestine 2010 Cengage-Wadsworth Stomach Small intestine Folds with villi on them A villus Capillaries The wall of the small intestine Is wrinkled into thousands of folds and is carpeted with villi. This photograph shows part of a human intestinal cell with microvilli. Lymphatic vessel Muscle layers beneath folds Between the villi tubular glands secrete enzyme-containing intestinal juice. Artery Vein Lymphatic vessel Microvilli Three cells of a villus. Each cell is covered with microvilli. Fig. 3-9, p. 87 The Small Intestine • Simple sugars and water-soluble vitamins are absorbed high in the small intestine because they require no special handling. • Nutrients released more slowly are absorbed further down. • When the mixture reaches the large intestine, water, fiber, and dissolved minerals are all that is left. • The lymphatic system and circulatory systems take over the job of transporting nutrients. 2010 Cengage-Wadsworth The Large Intestine • The large intestine is about 1.5 meters long and is larger in diameter than the small intestine. • No digestive enzymes are secreted because chemical digestion is complete. Anatomy of the large intestine 2010 Cengage-Wadsworth Transverse colon Descending colon Ascending colon Ileocecal valve Cecum Appendix Rectum Internal anal sphincter (smooth muscle) Sigmoid colon External anal sphincter (skeletal muscle) Anal canal Fig. 3-10, p. 88 The Large Intestine • Naturally occurring bacteria reside in the large intestine and are responsible for: Digestion of some fiber and leftover carbohydrate. Synthesis of absorbable vitamin K. • Primary functions of the large intestine: Absorb dissolved minerals and water. Eliminate waste products. 2010 Cengage-Wadsworth The Large Intestine • Final waste products are mixed with mucus to form fecal matter. • Fecal material normally consists of: water, undigested fiber, bilirubin, bacteria, small amounts of salt. • Peristalsis is slower and occurs less frequently. • When the rectum fills with feces, the defecation reflex expels the waste products. 2010 Cengage-Wadsworth Accessory Organs of Digestion •Organs outside the digestive tract contribute digestive juices through a common bile duct into the small intestine. •The organs are: Liver Gallbladder Pancreas Accessory organs of digestion 2010 Cengage-Wadsworth Bile duct from liver Stomach Duodenum Hormones (insulin, glucagon) Blood Duct cells secrete Acinar cells aqueous sodium secrete digestive bicarbonate solutionenzymes Exocrine portion of pancreas (Acinar and duct cells) Endocrine portion of pancreas (Islets of Langerhans) The glandular portions of the pancreas are grossly exaggerated. Fig. 3-11, p. 89 The Liver • The liver determines the metabolic fate of every nutrient we digest and absorb. • The liver performs a wide variety of functions which are essential for life. • The liver produces bile which helps to emulsify fat and improve the efficiency of fat digestion. 2010 Cengage-Wadsworth The Gallbladder • The gallbladder is a sack attached to the liver where bile is stored and concentrated. • Bile empties from the gallbladder into the common bile duct. • When chyme with fatty contents enters the small intestine, a hormone stimulates the gallbladder to contract and empty bile into the small intestine. 2010 Cengage-Wadsworth The Pancreas • The Pancreas has both endocrine and exocrine functions. Endocrine: a term to describe a gland secreting or a hormone being secreted into the blood. Exocrine: a secretion that is expelled through a duct into a body cavity or onto the surface of the skin. 2010 Cengage-Wadsworth The Pancreas • Endocrine functions include: Secretion of the hormones insulin and glucagon which regulate blood glucose levels. • Exocrine functions include: Secretion of digestive enzymes which act on carbohydrates, proteins, fats and bicarbonate. These are secreted into the duodenum. 2010 Cengage-Wadsworth Metabolism Breaking Down Nutrients for Energy: • Nutrients are absorbed from the digestive system into the blood where they converge from capillaries, into veins and then into a single large vein. • This vein carries nutrients to the liver where they break up into a vast capillary network. 2010 Cengage-Wadsworth Metabolism • Liver cells process the nutrients: Converts carbohydrate into glucose. Stores excess glucose as glycogen or fat. Reassembles fats and packages them for transport or storage. Alters amino acids as needed to make protein or other amino acids. 2010 Cengage-Wadsworth Metabolism • Nutrients leaving the digestive tract by way of lymph as chylomicrons circulate through the body. Cells can withdraw fats. Some find their way into the blood and circulate through to the liver. 2010 Cengage-Wadsworth Metabolism • New products of liver metabolism are released into the bloodstream and circulate to other cells of the body. These products are: Glucose Fat packaged with protein (lipoprotein) Amino acids 2010 Cengage-Wadsworth Metabolism • Surplus fat can be removed by the cells and made ready for storage. The human body has infinite storage capacity. • Liver glycogen provides a reserve supply of glucose. The body can draw from this reserve during intervals when glucose is not ingested and absorbed. This supply lasts about 3 to 6 hours. 2010 Cengage-Wadsworth Metabolism • The storage systems for glucose and fat ensure that the cells will not go without energy nutrients except under extreme conditions. • Other storage systems include: Protein held in an available pool. Liver and fat cells store many vitamins. Bones provide reserves of calcium and sodium. 2010 Cengage-Wadsworth Metabolism • The breaking down of body compounds is known as catabolism. • When the body needs energy, it breaks down any or all of the four basic units: Glucose Fatty acids Glycerol Amino acids 2010 Cengage-Wadsworth Metabolism • When the body does not require energy, end products of digestion are used to build body compounds in a process called anabolism. • Catabolism and anabolism are examples of energy metabolism. 2010 Cengage-Wadsworth Functional Food Pyramid 2010 Cengage-Wadsworth