Student name:……………………………………… Registration no……………………………….. Section no.:……………….
Faculty of Pharmacy
Computer aided drug design
Lecturer: Dr. Bilal Al-Jaidi
Student name:
Philadelphia University
Department of Pharmaceutical
Sciences
0511531
First semester 2014/2015
Second examination
Registration no.:
Question-1:
Succinate esters is a common prodrug for alcoholic compounds, explain that and describe the the
advantages for this prodrug?
Question-2
Progabide is an epinephrine prodrug; explain the way of activation and the benefits behind
preparing this prodrug?
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Question-3
Complete the following sentences:
1. Define tripartate prodrug:…………………………………………………………………………………………………
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2. Ki : ………………………………………………………………………………………………………………………………………….
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3. Catalytic amino acids:…………………………………………………………………………………………………
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4. Inhibition of destroying (deactivating enzyme is an example of drug synergism, explain that
(give an example)
Question-4
What are the main effects of intermolecular H-bond if formed in the chemical structure of drugs?
Give an example.
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Question-5
What are the main differences between receptor agonist and antagonists?
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Question-6
COMT is a regiospecific and reaction specific enzyme, explain that by drawing suitable structures:
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