Annual Report 2009
The Medical Statistics Group
Health Services Research Section
School of Health and Related Research
(ScHARR)
University of Sheffield
Regent Court
30 Regent Street
Sheffield
S1 4DA
Tel 0114 2220839
FAX 0114 2220749
www.shef.ac.uk/scharr/sections/hsr/statistics
Preface
The Medical Statistics Group (MSG) is located within the Health Services Research
(HSR) Section of the School of Health and Related Research (ScHARR) at the
University of Sheffield and works closely with the Medical School, the National
Institute for Health Research (NIHR) Research Design Service for Yorkshire and
Humber (previously the Trent Research Development and Support Unit (RDSU) and
the Clinical Trials Research Unit (CTRU).
The MSG aims to:
1. Develop new statistical methodology relevant to medical and health services
research;
2. Help ScHARR achieve a high rating at the Research Excellence Framework
(REF) (the successor to the Research Assessment Exercise ) by providing high
quality advice on research proposals and using modern statistical methods in the
analysis and display of data;
3. Provide direct input to medical and health services research projects through
collaborative research and consulting;
4. Develop and deliver statistics modules for undergraduate and postgraduate degree
schemes within ScHARR; the Faculty of Medicine, Dentistry and Health and the
University of Sheffield;
5. Train medical and health services professionals in the theory and application of
appropriate statistical methods in their own research;
6. Train the next generation of medical statisticians (through the newly introduced
MSc in Statistics with Medical Applications).
The Group operates in three main areas of research, teaching and consultancy.
MSG Annual Report 2009
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Highlights of 2009
Dawn Teare and Richard Jacques joined us in January 2009, followed by Munyaradzi
Dimairo and Neil Shephard in September and October respectively.
We have a strong list of peer reviewed publications with 21 joint-authored papers in
2009 (23 in 2008) and a further 6 non-refereed papers, letters or reviews and 3 books.
We also have a strong list of successful grant collaborations worth approximately £18
million.
In 2009 the Medical Statistics Group worked on new grant applications, to various
funders, from outline stage to full application. This resulted in 9 new research grants
with a value of approximately £4.9 million (£9M in 2008 which included the RDS
contract of £5M)).
After many years of negotiation, the MSc in Statistics with Medical Applications
commenced in October 2009 coordinated by Mike Campbell. This is part of the MSc
in Probability and Statistics run through the Maths Department
Members of the MSG are heavily involved with the teaching activities of ScHARR
and the wider Faculty of Medicine. This year saw the introduction of the MSc in
Clinical Research, for whom Dawn Teare delivered the Medical Statistics option.
Stephen Walters was promoted to a personal chair in August 2009 and Steven Julious
to Reader. Jenny Freeman has been appointed to the Council of the Royal Statistical
Society. Steven Julious has been appointed to Appraisal Committee D of NICE. Mike
Campbell has been appointed to the NIHR HSR Commissioning Board.
Steven Julious and Jenny Freeman were on study leave for the second semester in
2009. Georgina Jones has been on study/maternity leave for all of 2009.
Congratulations to Mike Bradburn and Tracey Young on the birth on Matthew and to
Stephen and Marion Walters on the birth of Alice!
MJC January 2010
MSG Annual Report 2009
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The Medical Statistics Group
Mike Bradburn (MB)
Statistician (CTRU)1
Mike Campbell (MJC)
Professor of Medical Statistics
Munyaradzi Dimairo (MD)
Research Associate (CTRU)
Jenny Freeman (JF)
Senior Lecturer in Medical Statistics
Richard Jacques (RJ)
Research Associate
Georgina Jones (GL)
Senior Lecturer in Social Sciences
Steven Julious (SAJ)
Reader in Medical Statistics
Neil Shephard (NS)
Research Associate (CTRU)
M. Dawn Teare (MDT)
Lecturer in Genetic Epidemiology
Stephen Walters (SJW)
Professor of Medical Statistics and Clinical Trials
1
Clinical Trials Research Unit
Members of ScHARR with an Interest in Statistics
Jon Nichol (JPN)
Professor of HSR
MCRU
Alicia O’Cathain (AOC)
Professor of HSR
MCRU
John Stevens
Deputy Director, CHEBS
HEDS
Tracey Young (TY)
Lecturer
HEDS
Mark Strong (MS)
Clinical Lecturer
Public Health
Patrick Fitzgerald (PF)
Research Fellow
HEDS
Dave Saxon (DS)
Research Associate
Mental Health
MSG Annual Report 2009
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Teaching 2009 by the Medical Statistics Group
Undergraduate
Statistics to MBChB (JF, SAJ, SJW, RJ, Mark Strong)
Undergraduate/Postgraduate
Statistics for the Medical and Health Sciences (HAR6036) (SAJ, SJW, JF, MB MJC,
RJ)
Postgraduate
An Introduction to Statistics and Critical Appraisal (HAR6035) (MJC, JF, SJW. SAJ,
TY, RJ, MDT)
MSc Medical Statistics: Statistical Methods in Epidemiology (MJC, JVF, MDT)
MSc Medical Statistics: Further Clinical Trials (SAJ, MJC, JS, MB)
MPH An Introduction to Research Methods (HAR6030) (MJC, JVF)
MSc Genetic Epidemiology (MDT, MJC)
MPH (HSR) Promoting evidence based health care (MJC)
MSc Health and Social Care (distance learning) (including RTP and MSc in
Psychological Research Students (MB)
Specialist Registrars short course (MJC,JF)
MSc Renal Medicine (JF)
PhD graduates
Chirk Jeng Ng (full time): supervised by Nigel Mathers and MJC (submitted)
Xiaoyan Xue (full-time): supervised by Penella Woll and MDT (graduation July
2010)
Adriana Ismail ’Quality of Life in children with thalassaemia in Malaysia.’
(supervised by MJC) (graduation July 2010)
Ongoing PhD Students
Mubashir Arain (full time): supervised by Jon Nicholl & MJC
Elton Chanakira (full-time): supervised by Liddy Goyder (Public Health), JVF &
Alicia O’Cathain
Nicola Clibbens (part-time university staff candidate): supervised by Wendy Baird
(Public Health) & SJW
Khadija Rerhou (part-time university staff candidate): supervised by MJC and SJW
Olivier Wong (external): supervised by Nigel Mathers, MJC& JVF
Feng Lui (part-time): supervised by SAJ& SJW
Joseph Akanuwe: supervised by Liddy Goyder & SAJ
Sally Hartnell: supervised by Liddy Goyder & SAJ
Mamdooh Alonazi (full-time): supervised by Allan Hutchinson JVF & Rachel O’Hara
Victoria Brennan (full time): supervised by GLJ, SC Radley, Dixon S
Kay Bowen (full time): supervised by GLJ, DOC Anumba
Rosalind Haddrill (part-time): supervised by Jones GL, Anumba DOC Mitchell C
Nick Latimer (full time): supervised by Ron Akehurst, MJC, & TY (on maternity
leave)
Sarah Hargreaves (full time): supervised by Mark Hawley and MJC
Jennifer Lai (full time): supervised by SAJ, JVF & Suzanne Mason
Paul Mahoney (part-time) supervised by SAJ and MJC
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Alireza Dastgheib (joint location, full-time) supervised by MDT and Alison Gartland.
MD
Li Wei Water (Supervised by GLJ, TC Li)
MPH Student Dissertations 2009
Mubashir Arain: ‘Components of a standard Pilot study: A review of Feasibility
studies’. MJC
Samuel Lassa ‘An epidemiological evaluation of scabies in the United Kingdom’.:
MJC
Safia Bano ‘A literature review evaluate to what extent authors of clinical trials are
using the correct policy of intention to treat analysis’.: MJC
PhD Internal Examining
SJW
John Freeman , Simon Palfreyman, Heather Brown
External examining
MJC
PhD St George’s, University of London,
PhD University of Oslo.
External adviser: MSc Medical Statistics. University of Hong Kong
JF
MSc Statistical Epidemiology University of Leeds ,
Postgraduate Medical Statistics (various courses) University of Central Lancashire
MDT
PhD, King’s College, University of London.
SJW
MSc Public Health & Health Services Research. University of Newcastle
External Courses
Cluster Randomised Trials : afternoon course MSc Med Stats (Leicester) (MJC)
Cluster Randomised Trials. One day Erasmus Winter Course, Rotterdam (MJC)
Data Display. One day course RSS Conference Edinburgh (JVF)
Data Display. Two day course, Barcelona (JVF)
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2-day PSI Training Course on Patient reported outcomes in Clinical Trials and
Health-care evaluation: a practical guide to analysis and interpretation (SJW)
Evidence for Genetic Effects (in Introduction to Genetic Epidemiology). One lecture
(of four) comprising a one day course RSS Conference Edinburgh (MDT)
Genetics and Quantitative Traits ( in Introduction to Genetic Epidemiology). Half day
contribution to one week course. European Society of Human Genetics, Paris. (MDT)
Statistical component for module ‘Design and analysis in experimental research’
lectures and tutorials (10 contact hours) for MSc in Molecular Medicine, School of
Medicine (MDT)
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Medical Statistics Group peer-reviewed publications 2009
A. Pendse, A. Nisar, S. Z. Shah, A. Bhosale, JV Freeman, I. Chakrabarti. Surface
replacement trapeziometacarpal joint arthroplasty – early results. The Journal of Hand
Surgery (2009) 0: 0: 1–10
J Otasowie, J Freeman, R Duffy, C Hollis. Antipsychotic prescribing practice among
child psychiatrists and community paediatricians. Psychiatric Bulletin (2009), 33, 08 24000/1^4. doi: 10.1192/pb.bp.108.024000.
D. Sell, A. John, A. Harding-Bell, T. Sweeney, F. Hegarty, J. Freeman. Cleft Audit
Protocol for Speech (CAPS-A): a comprehensive training package for speech
analysis',International Journal of Language & Communication Disorders (2009). 44:
4: 529-548. URL: http://dx.doi.org/10.1080/13682820802196815
J Nicholl, J Turner, T Young, J Freeman, E Chanakira, S Dixon, M Santarelli, T
Ohn, S Cross, S Mason. The long term health and healthcare outcomes of accidental
(The HALO Study). Final Report. March 2009. DoH Policy Research Programme
Debono M, Ghobadi C, Rostami-Hodjegan A, Huatan H, Campbell MJ, NewellPrice J, Darzy K, Merke DP, Arlt W, Ross RJ. (2009)Modified-release hydrocortisone
to provide circadian cortisol profiles. The Journal of Clinical Endocrinology &
Metabolism. Doi:10.1210/jc-2008-2380.
Senn S and Julious SA. Assessing the repeatability of response in clinical trials.
Statistics in Medicine 2009 28:3189-3209
Parker SG, Oliver P, Pennington M, Bond J, Jagger C, Julious SA, et al.
Rehabilitation of older patients: day hospital compared with rehabilitation at home. A
randomised controlled trial. Health Technol Assess 2009; DOI: 10.3310/hta13000
Houghton S, Saxon D, Bradburn M, Ricketts T, Hardy G. The effectiveness of
routinely delivered cognitive behavioural therapy for obsessive compulsive disorder:
a benchmarking study. British Journal of Clinical Psychology In press. Electronic
pre-print at http://bpsoc.publisher.ingentaconnect.com/content/bpsoc/bjcp/pre-prints
Maheswaran R, Pearson T, Hoysal N, Campbell MJ (2009) Evaluation of the
impact of a health forecast alert service on admissions for chronic obstructive
pulmonary disease in Bradford and Airedale Journal of Public Health 2009; doi:
10.1093 /pubmed/fdp068
Nancarrow S, Moran A, Freeman J, Enderby P, Dixon S, Parker S, Bradburn M.
Looking inside the black box of community rehabilitation and intermediate care teams
in the United Kingdom: an audit of service and staffing configuration. Quality in
Primary Care. 2009; 17(5): 323-333.
Al-Azemi M., Jones G., Sirkeci F., Walters S., Houdmont M., Ledger W. Immediate
and delayed add-back hormonal replacement therapy during ultra long GnRH agonist
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treatment of chronic cyclical pelvic pain.
Gynaecology 2009;116(12): 1646-1656.
British Journal of Obstetrics and
Absolom K., Eiser C., Michel G., Walters S.J., Hancock B.W., Coleman R.E.,
Snowden J.A., Greenfield, D.M. Follow-up care for cancer survivors: views of the
younger adult. British Journal of Cancer 2009; 101(4 ): 561-567.
Greenfield D.M., Absolom K., Eiser C., Walters S.J., Michel G., Hancock B.W.,
Snowden J.A., Coleman R.E. Follow-up care for cancer survivors: the views of
clinicians. British Journal of Cancer 2009; 101(4): 568-574.
Peters J., Parry G.D., Van Cleemput P., Moore J., Cooper C.L., Walters S.J. Health
and use of health services: a comparison between Gypsies and Travellers and other
ethnic groups. Ethnicity & Health 2009; 14(4): 359-377.
Morrell C.J., Warner R., Slade P., Dixon S., Walters S., Paley G., Brugha T.
Psychological Interventions for Postnatal depression: Cluster Randomised Trial and
Economic Evaluation (The PoNDER Trial). Health Technology Assessment, 2009;
13(30):1–176.
Walters S.J. Consultants’ forum: should post hoc sample size calculations be done?
Pharmaceutical Statistics 2009; 8(2): 163-169.
Naylor P.B., Cowie H.A., Walters S.J., Talamelli L., and Dawkins J. Impact of a
mental health teaching programme on adolescents. British Journal of Psychiatry 2009;
194: 365-370.
Farndon L.J., Barnes A., Littlewood K., Harle J., Beecroft C., Burnside J., Wheeler
T., Morris S., and Walters S.J. Clinical audit of core podiatry treatment in the NHS.
Journal of Foot and Ankle Research 2009, 2:7 doi:10.1186/1757-1146-2-7
Morrell C.J., Slade P, Warner R., Paley G., Dixon S., Walters S.J., Nicholl J.P.,
Brugha T., Barkham M., Parry G. Nicoll J.P. Clinical effectiveness of health visitor
training in psychologically informed approaches for depression in postnatal women:
pragmatic cluster randomised trial in primary care. British Medical Journal 2009; 338:
1-12.
Read R.C., Teare M.D., Pridmore A.C., Naylor S.C., Timms J.M., Kaczmarski E.B.,
Borrow R., Wilson A.G. The tumor necrosis factor polymorphism TNF (-308) is
associated with susceptibility to meningococcal sepsis, but not with lethality. Critical
Care Medicine 2009 37 (4): 1237-1243.
Xue XY Teare MD, Holen I, Zhu YM, Woll PJ.(2009) Optimizing the yield and
utility of circulating cell-free DNA from plasma and serum. Clinica Chimica Acta
2009, 404: 100-104.
MSG Annual Report 2009
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Books
Campbell MJ and Swinscow TDV Statistics at Square One. 11th ed Oxford; BMJ
Books Blackwell Publishing 2009
Walters S.J. Quality of life outcomes in clinical trials and health care evaluation: a
practical guide to analysis and interpretation. Chichester: Wiley 2009.
Julious SA. Sample Sizes for Clinical Trials. Chapman and Hall, 2009
Book Chapters
Walters S.J. What is a Cox Model? 2nd edition. Hayward Medical Communications,
2009.
Freeman J.V. Confidence Intervals. 2000 word essay for the Encyclopedia of
Medical Decision Making; Ed: Michael Kattan. Sage publishing. 2009
Book Reviews
Campbell MJ Hayes RJ and Moulton Cluster Randomised Trials Chapman and
Hall/CRC press. Biometrics, 65, 1307-8, 2009
Letters
Campbell MJ. (2009) Resting heart rate as predictor, what about absolute risks? BMJ,
338: b1197.
Journal Articles & Reports
J Freeman, T Young. Correlation coefficient: association between two continuous
variables. Scope. June 2009
J Thompson, H Cocker, R Coleman, B Colwell, J Freeman, K Holmes, M Reed.
CA93- Breast cancer aftercare; Preparing patients for discharge from routine hospital
follow-up (PREP). Draft Report. June 2009. Weston Park Hospital Cancer Appeal.
Invited Conference Talks and Seminars
MJC
Sample size calculations: Past, present and future’ University of Southampton Public
Health, April
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Workshop on ‘Adaptive designs’ with SA Julious. Randomised Controlled Trials in
Public Health and Health Services Research. One day conference hosted by Sheffield
CTRU with the Society for Social Medicine April
A statistician on a NICE Appraisal Committee: a personal view. University of
Southampton, Statistics Dept, Dec.
Royal Statistical Society Conference Edinburgh September
Patient decision aids: communicating risk to patients to aid decisions
Societé Francais de Data and Statistique (SFDS)
Organizing Committee Biopharmacy Conference Paris, September
JVF
J Freeman, J Crossley, F Hamilton, M Segwagwe, C Kok Shun. The application of
problem-based learning to statistics education: a case study. International Statistics
Institute 57, Durban South Africa, August 2009,
J Freeman, J Crossley, F Hamilton, M Segwagwe, C Kok Shun. What statistics do
doctors feel they need to know. Annual meeting for teachers of Medical Statistics,
Leeds, July 2009
J Freeman. How (not) to Display Data. PSI data display study day, Dec 2009
SAJ
Julious SA. Using meta analyses to help design prospective clinical trials. EFSPI
Scientific meeting on meta analysis. Basel, 2009
O’Kelly M, Julious S, Pyke S, Day S, Todd S, Seldrup J, Matcham J, Davies J.
Making available information from studies sponsored by the pharmaceutical industry:
some current practices. PSI Conference, Brighton, 2009
Pyke S, Julious S, Day S, O’Kelly M, Todd S, Davies J, Matcham J. The potential
for bias in reporting of industry sponsored clinical trials. PSI Conference, Brighton,
2009
Matcham J, Julious S, Pyke S, O’Kelly M, Todd S, Davies J, Seldrup J and Day S.
Proposed best practice for statisticians in the reporting of industry sponsored clinical
trials in medical journals. PSI Conference, Brighton, 2009
SJW
Statistical methods for Patient Reported Outcome Measure validation and adaptation.
Takeda GRD, London, October 2009.
MSG Annual Report 2009
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Therapist effects in randomised controlled trials – What to do about them. Health
Services Research Seminar Programme. ScHARR, Sheffield, January 2009.
GLJ
‘Quality of life in endometriosis’ Endometriosis UK conference (Sheffield, January
2009)
Contributed talks and posters
Talks
Terry Brugha T., Morrell C.J., Slade P., Walters S., Dixon S., Prevention of postnatal
depression: cost-effectiveness of health visitor training; results from a cluster
randomised controlled trial in primary care. 9th Workshop on Costs and Assessment
in Psychiatry - Quality and Outcomes in Mental Health Policy and Economics,
Venice, Italy, March 2009.
Posters
Greenfield D.M., Ross R.J., Walters S.J., Hancock B.W., Coleman R.E., Snowden
J.A., Ledger W.L. Inhibin B and AMH are NOT predictors of serum testosterone in
young men after cancer. Society for Endocrinology BES 2009, Harrogate, UK, March
2009.
Internal Positions
Mike Campbell. University Court, Course Director MSc Statistics with Medical
Applications, ScHARR Promotions panel committee
Steven Julious Chair of the CTRU, University Senate
Stephen Walters
Course Director MPH (Health Services Research); University
Senate; University of Sheffield’s Staff Promotion Panels (for Grades 1 to 6); University
of Sheffield’s Appeals Committee of Senate and Discipline Committee; Senate
representative on the University of Sheffield Faculty Promotion Panels, for Grades 8 &
9.
Jenny Freeman University Court, Faculty Student Review committee, Maths and
Statistics Help centre (MASH) steering committee & Management group. Examinations
officer for ScHARR. Course director for MSc in Medical and Health Sciences.
M. Dawn Teare. Quality and Progression Officer – ScHARR PGR Committee. HSR
representative ScHARR REF Task Group.
MSG Annual Report 2009
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External Positions
Mike Campbell is a member of Appraisal Committee C for the National Institute for
Health and Clinical Excellence. He continues on the Education Committee of the
International Society for Clinical Biostatistics (ISCB). He is a member of the NIHR
Programme Grants Committee and the NIHR HSR Commissioning Board. Mike is a
member of Data Monitoring and Ethics Committees for the FACS trial (University of
Nottingham), SHIFT trial (University of Leeds), the ZiPP trial (University of
Edinburgh) and the osteoporosis in men trial (Novartis).
Georgina Jones continues to be on the Executive Board for the national charity PCOS
UK. She is on the Editorial Board for the journal of Health and Quality of Life
Outcomes. She is an expert member of the South Sheffield Ethics Committee.
Stephen Walters is a member of and Secretary to Royal Statistical Society Medical
Section Committee. He is also a judge for Royal Statistical Society Manchester
Student Project Prize and a member of the conference organising committee for RSS
2009. Stephen is a member of the Public Health Interventions Advisory Committee
(PHIAC) of the National Institute for Health and Clinical Excellence. He is also a
member of the Editorial Board for the journal of Health and Quality of Life Outcomes
and a member of the International Advisory Board for the journal of Quality of Life
Research.
Steven Julious is a member of the Editorial Advisory Board for the journals
Pharmaceutical Statistics and Statistical Methods in Medical Research. Steven is
guest editor for a special issue of Statistics Methods in Medical Research on drug
development. Steven member of Appraisal Committee C for the National Institute for
Health and Clinical Excellence. Steven is also on the DMCs of two trials the
MUSTARDD trial and the SABRE trial.
Jenny Freeman is a member of the Royal Statistical Society Council, the Medical
Statistics committee and is chair of the Royal Statistical Society local group. She is a
member of the Trial Steering Committee for the VENUS IV trial for the treatment of
leg ulcers (University of York) and is a member of the Scientific Review Panel for the
Sheffield Health and Social Care Consortium. She is on the editorial board for
Nephron: Clinical Practice.
Refereeing
Both Mike Campbell and Stephen Walters are reviewers for the BMJ, whilst Jenny
Freeman is a statistical referee for the BJGP, the Journal of Health and Social Care
and the Statistics Education Research Journal. Stephen has acted as a referee for the
following: Quality of Life Research; Statistics in Medicine; Pharmaceutical Statistics;
Health and Quality of Life Outcomes; International Journal of Surgery; Medical
Research Council (MRC) Clinician Scientist Fellowship Scheme and the NHS R & D
MSG Annual Report 2009
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Health Technology Assessment (HTA) Programme; NIHR Programme Grants Scheme.
GLJ is a reviewer for the academic journals, Family Practice, British Journal of
Obstetrics & Gynaecology, European Journal of Obstetrics & Gynaecology, Journal
of Clinical Epidemiology & Public Health, Health & Quality of Life Outcomes,
Quality of Life Research, International Journal of Clinical Practice and Social Science
& Medicine. Steven Julious is a reviewer for many journals including Pharmaceutical
Statistics, Statistics in Medicine and Statistical Methods in Medical Research and is a
reviewer for the HTA, MRC and the RfPB programs.
Clinical Trials Research Unit
The Medical Statistic Group plays a key role in the success of the CTRU enabling it
to grow from just one person (Steven Julious) to over 20 today. Mike Bradburn,
Munyaradzi Dimairo and Neil Shephard are whole time in the CTRU and Steven
Julious is 20%. However the whole group contributes to the CTRU through input to
grant applications and in an advisory capacity.
MSG Annual Report 2009
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Research Awards and Grants (new and ongoing)
New
NIHR PAINTED- Evaluation and development of triage methods used to select
patients with suspected pandemic influenza for hospital admission. Goodacre S (PI),
Nicholl J, Campbell MJ, Strong M, Challen K, Walter D, Bently A, Wilson R. £181K
HTA- REPOSE (Relative Effectiveness of Pumps Over MDI and Structured
Education) Trial Heller S, Cooper C, Waugh N, Taylor C, Thompson G, Barnard K,
Campbell M, Rogers H, Bradburn M, Dixon S, Smithson W, Thekkapat S, Green F,
Clark M, Abraham P, Evans M, Amiel S, Lawton J, Hammond P, Ward C, Brennan
A, Duennas A, about £1.5M
NIHR Research for Patient Benefit. Evaluating cost effectiveness of computer
therapy compared with usual stimulation for people with long standing aphasia: a
pilot study. (PI) Palmer, R, Co-applicant Julious S. £250,000, .
NIHR-HTA – TABUL The role of ultrasound compared to biopsy of temporal
arteries in the diagnosis and treatment of giant cell arteritis. Luqmani R,(PI)
Bradburn M, Hutchings A, Wailoo A, Dasgupta B, Salmon J, Wakefield R, McNally
R, Hamilton W, McDonald B, Wolfe K. £1.4m
NIHR HTA Head Injury Transportation Straight to Neurosurgery (HITS-NS):
feasibility study. Fiona Lecky, University of Manchester (PI) J Freeman coapplicant. £748,889
SHIRE Pharmaceutical collaboration Assessing the impact of a child with ADHD on
the health and well-being of their families. S Walters, J Brazier, S Dixon, C Cooper.
Approx £400K
NIHR - Bone Metabolism Unit Trials. Eastell R(PI) , Cooper C, M Bradburn ,
Chater T. Approx £140K
NIHR Research for Patient Benefit (RfPB) - Pilot work for a RCT of a brief
psychological intervention for non-epileptic seizures (NEST). M Reuber (PI), S
Howlett, G Lawton, A House, S Kemp, RJ Brown, M Bradburn £200K
NIHR Research for Patient Benefit (RfPB) PB-PG-0808-17148 The AHEAD
Study: Managing anticoagulated patients who suffer head injury. S Mason PI Coapps_D Teare, Goodacre, Holmes, Stevenson, Ramlakhan. £230K over 2 years
Ongoing
SDO Enhancing the effectiveness of interprofessional working: costs and
outcomes.Enderby P (PI), Nancarrow S, Moran A, Smith A, Ellis L, Parker S,
Campbell MJ, Akehurst R. £335,135
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UniPath M Campbell (PI), R Eastell .Unipath. Statistician to analyse data on
osteoporosis. £153,361 over 2 years
Research for Patient Benefit. Evaluating cost effectiveness of computer therapy
compared with usual stimulation for people with long standing aphasia: a pilot study.
Palmer R, Julious S, Enderby P, Cooper C, Dixon S, Marshall M and Mortley J. (PBPG-1207-14097), 2008, £250,000
NHS Health Technology Assessment Programme. Infrastructure support for
Clinical Trials Research Unit. Cooper C (PI) and Julious S. £600,000 (for 3 years to
be reviewed and annually re-awarded depending on performance targets for the Clinical
Trials Research Unit), 2008
Yorkshire and Humber Research Design Services (YHRDS) £5,000,000 Steven
Walters, Co-applicant, 60 Months 2008-2013, Funding body: NHS National Institute
forHealth Research PI R. Akehurst
NHS NIHR Research for Patient Benefit (RfPB) programme Stephen Walters
Extension of mammographic breast screening to the over 70s: Assessment of efficacy,
practicality and patient preferences £228,299 2007-2010 PI: Lynda Wyld
NHS NIHR HTA Clinical Trials Stephen Walters co-applicant. A randomised
controlled trial and cost-effectiveness evaluation of "booster" interventions to sustain
increases in physical activity in middle-aged adults in deprived urban neighbourhoods
£1,200,000 Co-applicant 48 Months 2008-2012 PI: Elizabeth Goyder
NHS NIHR Research for Patient Benefit (RfPB) programme Stephen Walters Coapplicant, The long term effectiveness of 40% salicylic acid plasters on corns an RCT
£250,000 2008-2011 PI: Wesley Vernon
NHS NIHR Research for Patient Benefit Mike Bradburn Co-applicant Randomised
controlled trial of a brief psychological intervention for non-epileptic seizures
(NEST2) £185,814 26 Months 2009-2011 P I: Marcus Reuber
MS Society JV Freeman.co-applicant Computerised cognitive behavioural therapy
for treatment of depression in people with MS: pre-clinical trial exploratory study PI
Cindy Cooper. Total £213k.
NHS HTA SA Julious.co-applicant Randomised Assessment of Treatment using
Panel Assay of Cardiac markers (RATPAC) (PI S Goodacre). £716,500
Diabetes UK JV Freeman. Kids In Control OF Food: A multi-centre, cluster
randomised controlled trial comparing structured education (the KICk-OFF course)
with standard care in 11-16 year olds with Type 1 Diabetes (T1DM) on intensive
insulin therapy. (PI: K Price) £1,427,000.
National Osteoporosis Society JV Freeman. Genetic and architectural associations in
children who do or do not fracture (PI: Prof N Bishop). £126,191.
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NHS HTA 3Mg MJ Campbell Co-applicant A trial of nebulised versus injected
magnesium for acute asthma attacks (3Mg) (PI SGoodacre) Total £1,110,333 3 yrs
Funding Body
NIHR Programme Grant MJ Campbell co-applicant. Improving management of Type
1 diabetes in the UK: the DAFNE programme as a research test-bed (PI S Heller )
Total £1,983,000 over 3 years Funding body
HTA Research for Patient Benefit MJ Campbell co-applicant .The development and
evaluation of the effectiveness of a patient decision aid (PtDA) to improve decision
quality and health outcome in type 2 diabetic patients making treatment choices (PI N
Mathers), Total £250,000 over 2 year Funding Body
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