應用於慢性傷口之穿戴式監測系統
Development of a Wearable Monitoring
System for Chronic Wounds
Presenter：Wei-Siang Ciou
Adviser：Yi-Chun Du
Date：2015/12/13
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Outline
 Introduction
 Motivation and Purpose
 Literature Review
 Material and Methods
 Future Works
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Introduction
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Wound Classification
 Acute wounds：
 Injury to the skin that occurs suddenly
 Heals at a predictable and expected rate
 Chronic wounds：
 Not heals at a predictable and expected rate
 More than two weeks are considered
chronic
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Process of Wound Healing
Coagulation
Remodeling
Wound
Inflammation
Proliferation
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Causes of Chronic Wounds
 Systemic disease of human：
 Diabetes mellitus
 Weakened immune system
 Blood coagulation system disorder
 Local factors of human ：
 Malnutrition
 Elderly and pressure
 A sustained inflammatory state caused by infection
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Symptoms of Chronic Wounds
 Erythema
 Warmth around the wound
 Pain or tenderness
 Purulent or increased wound exudate
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Evaluation of
Wound Healing Process
 Diagnose with nursing staff
 Regularly to replace gauze and check the
wound healing
 Image pre-processing
 Segmentation and texture analysis together
with visual expert's evaluation
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
A major Healthcare Problem
In Taiwan, about 60,000 people die per year because of
wound infection and its complications
6.5 million people in the US suffer from a chronic
wound
Costing the United States billions of dollars a year
Global expenditures amount to $13 to $15 billion
annually
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Motivation and Purpose
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Clinical Issue Improvement
Reduce the risk of infection
Saving treatment time
Reduce health care costs
A monitoring system to assess wound
healing situations
生醫系統整合實驗室 Integrated Biomedical System Laboratory
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Literature review
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Moist Wound Healing
 Dr. George Winter(1971)
Moist wound healing
Dry wound healing
Slow
Big
High
Difficult
Rates of healing
Wound tension
Scar formation
Wound Assessmen
Fast
Small
Low
Easy
Jones, M. L. (2015). A short history of the development of wound care dressings. British
Journal of Healthcare Assistants, 9(10).
生醫系統整合實驗室 Integrated Biomedical System Laboratory
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Temperature of the Wound
 The ideal wound temperature
 Identified as body temperature (33~37 degrees)
Dini, V., et al. "Correlation Between Wound Temperature Obtained With an Infrared Camera and
Clinical Wound Bed Score in Venous Leg Ulcers."Wounds: a compendium of clinical research
and practice 27.10 (2015): 274-278.
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Sensors for Detection of pH
• The natural pH of the skin
is typically between pH 4 and
pH 6 that impedes bacterial
proliferation.
• An injury creates a cutaneous
wound, it is normally regulated
at pH 7.4, can encourage bacterial
growth and thereby promote
infection.
McLister, A., Phair, J., Cundell, J., & Davis, J. (2014). Electrochemical approaches to the
development of smart bandages: A mini-review.Electrochemistry Communications, 40, 96-99.15
生醫系統整合實驗室 Integrated Biomedical System Laboratory
Advanced Wound Dressings
 Dry dressing：Sticking、Difficult to observe
 Foam Dressings： Difficult to fixed、Dry
 Hydrogel： Easily detached if the wound
exudate large amount
Can not Monitoring
吳伏坡. (2014). 高階傷口敷料市場分析: 濕性傷口敷料. 暨南
大學經營管理碩士在職專班學位論文, 1-60.
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Negative Pressure Wound Treatment
Wound Pad：
Deainage accessories
Drape：
Occlusive patch
Wound derssing：
PU foam
Negative Pressure Wound
Therapy equipment
Webster, J., Scuffham, P., Stankiewicz, M., & Chaboyer, W. P. (2014). Negative pressure
wound therapy for skin grafts and surgical wounds healing by primary intention. The Cochrane
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Library.
生醫系統整合實驗室 Integrated Biomedical System Laboratory
Devon Medical in USA
Not be stitched
NPWT
Wound stitching
http://www.li-orange.com.tw/
生醫系統整合實驗室 Integrated Biomedical System Laboratory
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Material and Methods
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Wound Care System Integrated
Exterior
Function 1. Measurement the parameters of the wounds
2. User interfaces
3. Integrated the database system information
Technical
1.Humidity Sensor
2.RTD - PT100
3.BlueTooth 4.0
4.TI - MSP430
5.ZigBee Mesh
6.Capacitive pressure sensor
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
System Architectures
Filter
Rectifier
Mapping
Circuit
Temperature
/Humidity/
PH Value
Detection
Isolation
Amplifier
Amplifier
Decoding
Circuit
Conduction
Isolation
Protection
Current Limit
Protection
Circuit
Sensing The
Voltage
Source
User
Interface
Processor
ZigBee
Digital
Converter
Alarm
Unit
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Humidity Sensor
Characteristics
Sensing methods
IBS_Lab
Electrodes
Sensitivity
Flexible printed
circuit
< 0.1ml
Sensing Material
Liquid
Alarm
Sound and Light
Material
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Mapping Circuit
Mapping Circuit
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Architecture of Humidity Sensor(1)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Architecture of Humidity Sensor(2)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Blood Leakage Detection Device
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Temperature Sensor
 Resistance Temperature Detector
 Extremely small in size
 Wide detection range
 High accuracy
 Low prices
R=Ro(1+αT)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Architecture of
Humidity & Temperature Sensor
Humidity sensing area
Temperature sensing area
Waterproof layer
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Wearable Monitoring System
 BM-S02
 Low power consumption
 Tiny size
 Long transmission distance
 Strong anti-interference ability
 Rechargeable Battery Module
 Reusable
 Replace adapter
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Development of Interface
• Microsoft Visual Studio 2013 C # language
• Through Windows Development Kit Window Forms
• Visual programming environment
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Database System
 MySQL
 Open source code
 High efficiency
 Free Software
Database System
 Data table
Personal
Information
Wound
Status
Heart Rate
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Mobile Application(1)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Mobile Application(2)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Mobile Application(3)
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生醫系統整合實驗室 Integrated Biomedical System Laboratory
Future Works
 Temperature and humidity sensing patch test
 Experiment design
 Integration of the physiological parameters
 Health insurance card for the system login
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Thank you for your attention!
http://faculty.stust.edu.tw/~terrydu/
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