Principal Investigator/Program Director (Last, First, Middle):
Kagan, Harris
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Petra Schmalbrock, Ph.D.
Associate Professor
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
B.S.
M.S.
Ph.D.
1975
1977
1982
Westfalische Wilhelms Univ. Munster, Germany
Westfalische Wilhelms Univ. Munster, Germany
Westfalische Wilhelms Univ. Munster, Germany
FIELD OF STUDY
Physics
Physics
Physics
Please refer to the application instructions in order to complete sections A, B, and C of the Biographical
Sketch.
A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List
any honors. Include present membership on any Federal Government public advisory committee.
Professional Positions
1983-84
1985-85
1985-87
1987
1987-88
1988-90
1990-1995
1995-2001
2001-present
Postdoctoral Research Associate, Dept. of Physics, The Ohio State University.
Lecturer, Dept. of Physics, The Ohio State University.
Research Associate, Dept. of Radiology, The Ohio State University.
Instructor, Pulse Sequence Programming, The General Electric Company.
Research Scientist, Dept. of Radiology, The Ohio State University
Consultant, The General Electric Company.
Research Scientist, Dept. of Radiology, The Ohio State University
Assistant Professor, Dept. of Radiology, The Ohio State University
Associate Professor, Dept. of Radiology, The Ohio State University
B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in
preparation.
Partial Listing of 66
1- Schmalbrock P, J Pruski L Sun, A Rao JW Monroe, Phased Array RF Coils for High-Resolution Imaging of the Inner Ear and the Brain
Stem, Journal of Computer Assisted Tomography 19, 8-14, 1995
2- Oehler M, P Schmalbrock, DW Chakeres S Kurucay, Artifacts Related to Magnetic Susceptibility Differences Between Bone and Air
on High Resolution MRI of the Temporal Bone, AJNR 16, May 1995
3- Schmalbrock P, Challenges for in vivo High Resolution MRI, International Journal of Neuroradiology, 2, 45-68, 1996
4- Ying K, BD Clymer, P Schmalbrock, Adaptive Filtering Processing for Magnetic Resonance Images, JMRI 6, 367-377, 1996
5- Schmalbrock P, DW Chakeres, PM Williams, T Dailiana, MC Oehler, DB Welling, L Roth, Submillimeter Resolution MRI of the
Endolymphatic Sac in Healthy Subjects and Patients with Meniere's Disease, AJNR 17, 1707-1716, 1996
6- Yagel R, D Stredney, GJ Wiet, P Schmalbrock, L Rosenberg, DJ Sessanna Y Kurzion, "Building a virtual environment for endoscopic
sinus surgery simulation", Comput & Graphics 20, 813-823, 1996
7- DB Welling, MW Clarkson, BA Miles, P Schmalbrock, PW Williams, DW Chakeres, MC Oehler, Sub-Millimeter MRI of the
Temporal Bone in Meniere's Disease, Laryngoscope 106, 1359-1364, 1996
8- Fishbein MH, Gardener KG, Potter CJ, Schmalbrock P, Smith M, Introduction of fast MR imaging in the assessment of hepatic
steatosis, Magn. Reson. Imag. 15, 287-293, 1997
9- Dailiana T, DW Chakeres, P Schmalbrock, High Resolution MRI of the Parotid Gland, AJNR 18, 165-172, 1997
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Principal Investigator/Program Director (Last, First, Middle):
Kagan, Harris
10-Kurucay S, Schmalbrock P, Chakeres DW, Keller PJ, A Segment Interleaved Motion Compensated Acquisition in the Steady State
Technique for High Resolution Imaging of the Inner Ear, JMRI 7,1060-1068, 1997
11-Stone J, Chakeres D Schmalbrock P, MR imaging of hearing loss, MRI clinics of North America 1998
12-Hines JV, Ammar GM, Schmalbrock P, Paramagnetic oligonucleotides: Contrast agents for MRI with proton relaxation
enhancement effect, Bioconjugate Chem. 10, 155-158, 1999
13-Schmalbrock P, Chakeres DW, Monroe JW, Saraswat A, Miles BA, Welling DB, Measurement of internal auditory canal tumor
volumes with contrast enhanced T1-weighted and steady state T2-weighted gradient echo imaging, AJNR 20, 1207-1213, 1999
14-Massick DD, DB Welling, EE Dodson, HN Nagaraja, P Schmalbrock, DW Chakeres, Tumor growth and audiometric changes in
vestibular schwannomas managed conservatively, Laryngoscope 110, 1843-1849, 2000
15-Schmalbrock P, Comparison of 3D spin Echo and Gradient Echo Sequences for high resolution Temporal Bone Imaging, JMRI
12, 814-825, 2000
16-Levy CE, Nichols DS, Schmalbrock P, Keller P, Chakeres DW, Constraint induced movement therapy for post-acute stroke upper
limb hemiplagia restores function and induces plasticity as seen on fMRI, Am J Phys Med Rehabil.2001 Jan;80(1):4-12
17-Schmalbrock P, Hines JV, Ammar GM, Lee SM, Kwok EWC, Characterization of Single Layer Cell Cultures at 1.5T:A
Feasibility Study, T1 measurements in cell cultures: A new tool for characterizing contrast agents at 1.5T , J MAGN RESON
IMAGING 14: (5) 636-648 NOV 2001
18-James D, Clymer BD, Schmalbrock P, Texture detection of simulated microcalcification susceptibility effects in magnetic
resonance imaging of breasts J MAGN RESON IMAGING 13: (6) 876-881 JUN 2001
19-Wiet GJ, Stredney D, Sessanna D, Bryan JA, Welling DB, Schmalbrock P, Virtual temporal bone dissection: An interactive
surgical simulator OTOLARYNG HEAD NECK 127: (1) 79-83 JUL 2002
20-Christoforidis GA, Grecula JC, Newton HB, Kangarlu A, Abduljalil AM, Schmalbrock P, Chakeres DW, Visualization of
microvascularity within glioblastoma multiforme utilizing 8 Tesla high- resolution MRI, AJNR 23: (9) 1553-1556 OCT 2002
21-Algaze A, Roberts C, Leguire LE, Schmalbrock P, Rogers GL. Functional Magnetic Resonance Imaging as a Tool for
Investigating Amblyopia in the Human Visual Cortex: A Pilot Study, J AAPOS 6: (5) 300-308 OCT 2002
22-Truong T, Clymer BD, Chakeres DW, Schmalbrock P, Three-dimensional Numerical Simulations of Susceptibility-Induced
Magnetic Field Inhomogeneities in the Human Head, MRI MRI 20 (10), 759-770, 2002
23-Roychowdhury S, Peng RQ, Baiocchi RA, Bhatt D, Vourganti S, Grecula J, Gupta N, Eisenbeis CF, Nuovo GJ, Yang WL,
Schmalbrock P, Ferketich A, Moeschberger M, Porcu P, Barth RF, Caligiuri MA, Experimental treatment of Epstein-Barr virusassociated primary central nervous system lymphoma, CANCER RESEARCH 63 (5): 965-971, 2003
24-Abduljalil AM, Schmalbrock P, Novak V, Chakeres DW, Enhanced grey and white matter contrast of phase susceptibility
weighted images at ultra high field MRI, JMRI 18 (3):284-290, 2003
25-Dashner RA, Chakeres DW, Kangarlu A, Schmalbrock P, DePhilip RM, MRI Visualization of the Brain’s microvasculature: A
comparison of live and postmortem studies at 8Tesla, AJNR 24:1881-1884, 2003
26-Chakeres DW, Whitaker CD, Dashner R, Scharre DW, Beversdorf DQ, RayChaudhury A, Schmalbrock P, High-Resolution 8
Tesla Imaging of the Formalin-Fixed Normal Human Hippocampus, Clinical Anatomy 2005; 18:88-91.
27-Christoforidis GA, Kangarlu A, Abduljalil AM, Schmalbrock P, Chaudhury A, Yates A, Chakeres DW, Susceptibility-based
Imaging of Glioblastoma microvascularity at 8T: Correlation of MR Imaging and postmortem pathology, AJNR 25: 756-760, 2004
28-Ibinson J, Small RH, Schmalbrock P, Clark D, Functional MRI studies of Pain: Results of a pilot study using a whole brain fMRI
technique, Anesthesiology 101: 960-969, 2004
29-Ilangovan G, Bratasz A, Li HQ, Schmalbrock P, Zweier JL, Kuppusamy P, In vivo measurement and imaging of tumor
oxygenation using coembedded paramagnetic particulates, Magn Reson Med 52 : 650-657, 2004
30-Chakeres DW, Whitaker CD, Dashner R, Scharre DW, Beversdorf DQ, RayChaudhury A, Schmalbrock P, High-Resolution 8
Tesla Imaging of the Formalin-Fixed Normal Human Hippocampus, Clinical Anatomy 18 (2): 88-91 MAR 2005
31-Ibrahim TS, Mitchell C, Schmalbrock P, Lee R, Chakeres DW, Electromagnetic perspective on the operation of RF coils at 1.511.7 Tesla, Magn. Reson. Med 54 (3): 683-690 SEP 2005
32-Truong TK, Chakeres DW, Schmalbrock P, Effects of Static and Radiofrequency Magnetic Field Inhomogeneity in Ultra-High
Field Magnetic Resonance Imaging, Magn Reson Imag 24, 103-112, 2006
33-Wiet GJ, Schmalbrock P, Powell K, et al., Use of ultra-high-resolution data for temporal bone dissection simulation,
Otolaryngology-Head And Neck Surgery 133 : 911-915 DEC 2005
34-Truong TK, Chakeres DW, Scharre DW, Beversdorf DQ, Schmalbrock P, Blipped Multi Gradient Echo Slice Excitation Profile
Imaging (bmGESEPI) for Fast and Accurate T2* Measurements with Bo Inhomogeneity Compensation, MRM 55: 1390-1395
35-Tivarus ME, J. Ibinson, A. Hillier, P. Schmalbrock, D. Q. Beversdorf, An fMRI study of semantic priming: modulation of brain
activity by varying semantic distances, Cognitive and Behavioral Neurology (in print)
36-Chang L, Abraham J, Lorenz M, Rock J, Akhmametyeva E, Mihai G, Schmalbrock P, Chaudhury A, Lopez R, Yamate J, John M,
Wickert H, Neff B, Dodson E, Welling D, Growth of Benign and Malignant Schwannoma Xenografts in Severe Combined
Immunodeficiency Mice, Laryngoscope 116: Oct 2006 (in print)
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Principal Investigator/Program Director (Last, First, Middle):
Kagan, Harris
Recent Peer Reviewed Abstracts
Schmalbrock P, Vogt K, Koch R, Sammet S, Duraj J, Knopp M, Comparison of Language Task fMRI at 3T and 7T, RSNA 2006
Schmalbrock P, Chakeres D, Kinson H, Heverhagen J, Duraj J, Knopp M, Sammet S, Koch R, Abduljalil A, Simultaneous BrightBlood/Black-Blood Cerebral MR Angiography at 7T, RSNA 2006
Schmalbrock P, Chakeres D, Abduljalil A, Wassenaar P, Thompson M, Knopp M, T2-weighted High Resolution 3D Imaging of the
Substantia Nigra at 7T, RSNA 2006
Schmalbrock P, Sammet S, Abduljalil A, Heverhagen J, Thompson M, Knopp M, et al Depiction of Inner Ear Anatomy at 7 Tesla,
RSNA 2006
C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and
non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly
indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant) in the research project. Do
not list award amounts or percent effort in projects.
ACTIVE
“Biomedical Imaging and Biomedical Structural, Functional and Molecular Imaging”
Biomedical Research Technology Transfer Fund ODOD AGMT TECH 03-051
Enterprise and Wright Center for Innovation in Biomedical Imaging
PI: Michael V. Knopp, M.D., Ph.D. Co-I: P Schmalbrock, PhD
07/10/03-01/10/07
30% Effort
“Biomedical Imaging and Biomedical Structural, Functional and Molecular Imaging”
7/1/2006-6/30/2009
BRTT- Continuation ( State of Ohio): PI Knopp MV, Co-I: Schmalbrock P et al
30% Effort
An enterprise of three partners, The Ohio State University, Case Western Reserve University, and Ohio-based Philips Medical
Systems, to leapfrog biomedical imaging as a key enabling technology in the State of Ohio for biomedical research and medical care.
“Validation and Dissemination of a Virtual Temporal Dissection Simulation”
12/1/03-11/30/08
NIH-NIDCD BRG (R01)
5% Effort
PI: G Wiet, Co-I: Stredney, Schmalbrock Welling, Powell et al
In this grant image processing tools for real time volume visualization of multi-resolution multi-modality data (CT and MRI) of the
temporal bone will be developed and used to design a virtual temporal dissection simulation. No overlap.
“Lung Cancer Prevention Program”
Biomedical Research Technology Transfer Fund ODOD
PI: Michael V. Knopp, M.D., Ph.D. Co-I: P Schmalbrock, PhD
07/10/03-01/10/07
10% Effort
“Dietary Fat, Obesity & Hepatic Insulin Resistance”
OARDC,
PI: Belury, Co-I: Wick, Kniss, Schmalbrock
This grant is to measure body fat composition in rat to assess dietary fat, no overlap
3/2005-2/2007
Consultant
PENDING
“Bone Strength Model from Clinical Resolution Imaging”
PI: Clymer, Co-I: Bertone, Schmalbrock, Stredney, Schmalbrock, Dapine, Litsky
“Development of a Digital Repository for Human Temporal Bone Research”
NIH: PI: Wiet, Co-I: Caluyurek, Kun, Saltz, Strednety, Schmalbrock
“Mega Wright Center of Innovation Imaging Consortium”
PI Knopp MV, Co-I: Schmalbrock P et al
“fMRI of Infantile Nystagmus”
NIH: PI: Fogt, Co-I Leguire, Kashou, Schmalbrock
“Neuronal plasticity at remote sites causes neuropathic pain after SCI”
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Principal Investigator/Program Director (Last, First, Middle):
Kagan, Harris
NIH: PI: Detloff, Co-I: Schmalbrock, Basso
PLANNED
“Magnetic Virus-like Particles for tumor targeting: Properties and MRI relaxation”
NIH, PI: P Schmalbrock, Co-I: Chalmers, Betenbaugh M Knopp
"Noradrenergicc system, stress, fMRI, cognition and Autism"
NIH, PI: Beversdorf, Co-I: Schmalbrock et al
COMPLETED DURING THE LAST 3 YEARS
“Motor Map Placiticity in Constraint Therapy for Stroke”
10/2002-9/2005
NIH 1R01HD/NS40984 –01A1 - Consortium with Wake Forest University
15% effort
PI: D Good OSU-PI: D Nichols, Co-I: P Schmalbrock, Y Mohammad
In this multi-center study sroke patients undergoing constraint physical therapy are evaluated using fMRI and TMS to better
understand the mechanisms of the healing process. There is no overlap.
“Ultra high resolution human MRI of gliomas”
NIH R21 CA092846-01A1
PI: G Christoferidis, Co-I: et al P Schmalbrock
8/2002-8/2004
5% effort
“Paramagnetic Oligonucleotides for Breast Cancer Imaging”
Consortium with Ohio University – DOD
OSU PI: P Schmalbrock, Ohio University PI: J Hines
7/1/99-10/10/03
5% effort
“Ohio Cellular and Molecular Imaging Consortium”
Ohio Board of Regents – Consortium with Case Western University
OSU-PI: P Schmalbrock
6/2002
$500,000
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