XIULU RUAN, M.D.
World Record Holder for achieving most medical
board/subspecialty board certifications in USA
Diplomate, American Board of Pain Medicine (DABPM)
Diplomate, American Board of Addiction Medicine (DABAM)
Diplomate, American Board of Electrodiagnostic Medicine(DABEM)
Diplomate, American Board of Interventional Pain Physicians (DABIPP)
Diplomate, American Board of Independent Medical Examiners(DABIME)
Diplomate, American Board of Physical Medicine & Rehabilitation (DABPMR)
Diplomate, Subspecialty Board Certification of Pain Medicine, American Board of
Physical Medicine & Rehabilitation AND American Board of Anesthesiology
Diplomate, Subspecialty Board Certification of Neuromuscular Medicine, American Board of
Physical Medicine & Rehabilitation AND American Board of Psychiatry and Neurology
Diplomate, American Board of Forensic Medicine (DABFM)
Fellow, Interventional Pain Practice (FIPP), World Institute of Pain
Fellowship Trained in Interventional Pain Medicine
Physicians' Pain Specialists of Alabama, P.C.
4682 Airport Blvd. Mobile, AL36608
Ph: 251-406-8989 Fax: 251-342-4910
email: xiuluruan@yahoo.com
Education:
M.D., Shandong Medical University, Jinan, Shandong Province, P.R. China, 9/19827/1988
MS., Natural Sciences, Louisiana State University, Baton Rouge, LA, USA, 9/19908/1993
Cardiology Fellowship: Shandong Academy of Medical Sciences, Jinan, China,
8/1988-8/1990
Medical Internship: Dept of Medicine, Worcester Medical Center, Worcester,
MASS, USA, 7/1998-6/1999
PM&R Residency: Dept of PM&R, Medical College of Wisconsin Affiliated
Hospitals, Milwaukee, WI, USA 7/1999-6/2002
Pain Management Fellowship: Center for Interventional Pain Management,
Dept. of Anesthesiology, Univ. of Michigan Health System
Health System, Ann Arbor, MI, 7/2002-7/2003
Clinical Experience in USA:
8/2003-Now: Pain Management Specialist at the Physicians' Pain Specialists of
Alabama, PC, 2001 Springhill Ave. Mobile, AL36607 USA Tel:251-478-4900
7/2002-7/2003: Clinical Pain Management Fellow in Center for Interventional Pain
Management, Dept. of Anesthesiology, Univ. of Michigan Health System, Ann
Arbor, MI48104, USA
7/1999-6/2002: Resident Physician at Dept. of Physical Medicine & Rehabilitation,
Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI53226, USA
7/1998-6/1999: Medical Internship at Dept. of Medicine, St. Vincent Hospital
(currently, Worcester Medical Center), Worcester, MASS 01608, USA
National & State Organizational/Societal Roles:
Immediate-Past President, Alabama State Chapter of American Society of
Interventional Pain Physicians (ALASIPP)
Immediate-Past President, Alabama State Chapter of American Society of Addiction
Medicine (ALSAM)
Founder and Executive Director, International Institute of Pain & Rehabilitation
(IIPR)
Former Director -at-Large, American Society of Interventional Pain Physicians
(ASIPP)
Board Certification:
1. American Board of Physical Medicine & Rehabilitation
2. American Board of Pain Medicine
3. American Board of Electrodiagnostic Medicine
4. American Board of Interventional Pain Physicians
5. American Board of Addiction Medicine
6. American Board of Independent Medical Examiners
7. American Board of Forensic Medicine
8. Subspecialty of Pain Medicine, American Board of Physical Medicine &
Rehabilitation AND American Board of Anesthesiology
9. Subspecialty of Neuromuscular Medicine, American Board of Physical Medicine
& Rehabilitation AND American Board of Psychiatry and Neurology
Fellow, Interventional Pain Practice (FIPP), World Institute of Pain
Academic/Advisory Appointments
Adjunct Clinical Associate Professor
Department of Anesthesiology
LSUHSC School of Medicine
Date of Appointment: Aug. 1, 2012 to present
Editor in Chief, Journal of Pain & Relief
Date of Appointment: May 2012 to present
Former Editorial Consultant, Pain Physician (Official Journal of the
American Society of Interventional Pain Physicians)
Date of Appointment: January 2007 to present
Editorial Board Member, Current Drug Abuse Reviews
Date of Appointment: April 2012 to present
Editorial Board Member, Analgesia & Resuscitation: Current Research
Date of Appointment: Aug. 2012 to present
Peer Reviewer, Pain Medicine (Official Journal of American Academy of Pain
Medicine)
Peer Reviewer, Expert Opinion on Pharmacotherapy
Peer Reviewer, Archives of Physical Medicine & Rehabilitation
Peer Reviewer, Postgraduate Medicine
Peer Reviewer, Current Drug Discovery Technologies
Peer Reviewer, Journal of Cancer Research & Experimental Oncology
Peer Reviewer, Journal of Pharmacy & Pharmacology
Peer Reviewer, Therapeutic Advances in Drug Safety
Peer Reviewer, American Journal of Hospice and Palliative Medicine
Peer Reviewer, Journal of Clinical Pharmacology
Licensure:
Alabama: Current
Michigan: Current
Florida: Current
Mississippi: Current
Publications:
Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived
Eicosanoids K. Node, Y.Huo, X. Ruan, B. Yang, M. Spiecker, K. Ley, D.C.
Zeldin, J.K. Liao; Science; Vol. 285, Aug. 20, 1999 pp.1276-1279
Activation of Guanine Nucleotide-binding Proteins and Induction of Endothelial
Tissue-type Plasminogen Activator Gene Transcription by Alcohol
A. Miyamoto, SX Yang, U Laufs, X. Ruan and JK Liao
The Journal of Biological Chemistry; Vol. 274, No. 17, April 1999;
pp. 12055-12060
Activation of Gs Mediates Induction of Tissue-Type Plasminogen Activiator Gene
Transcription by Epoxyeicosatrienoic Acids
K. Node, X. Ruan, J.W. Dai, S.X. Yang, D.C. Zeldin, J.K. Liao
The Journal of Biological Chemistry; Vol. 276, No. 19, May 2001;
pp.15983-15989
Edema Associated with Intrathecal Opioid Usage
X. Ruan, MD
Workers Comp Rx Press. Newsletter. Vol. 2, Issue 4, Oct. 1, 2006, pp. 2
Drug-related Side Effects of Long-Term Intrathecal Morphine
Therapy: A Focused Review
X. Ruan, MD
Pain Physician; Vol. 10, No. 2, March 2007; pp. 357-366
Opioid-induced Hyperalgesia
X. Ruan, MD
Workers Comp Rx Press. Newsletter. April 1, 2007. pp. 1-2
Priapism----A Rare Complication Following Continuous Epidural
Morphine and Bupivacaine Infusion
X. Ruan, MD, J.P. Couch, MD, R. Shah, MD, H. Liu, MS,
F. Wang, MD, S. Chiravuri, MD
Pain Physician; Vol. 10, Nov. 5, September 2007; pp. 707-711
Combinational Pharmacotherapy in Acute Pain Management
X. Ruan, MD
Workers Comp Rx Press Newsletter
Vol. 3, Issue 4, Oct. 1, 2007; pp 3
Acute Pain Management in Patient on Intrathecal Opioid Infusion for Chronic Pain
X. Ruan, MD
Pain Physician; Vol. 10, No. 6, November 2007; pp.780-781
Case Report: Persistent Hiccup Associated With Intrathecal Morphine Infusion
Pump Therapy
X. Ruan, MD, J.P. Couch, MD, R. Shah, MD, F. Wang, MD and H.Liu, MS
American Journal of Physical Medicine & Rehabilitation; December 2007
86(12):1019-1022
Severe Peripheral Edema During Continuous Epidural Morphine Infusion Trial
in a Opioid Tolerant Patient with Failed Back Surgery Syndrome
X. Ruan, MD, R. Tadia, MD, J. P. Couch, MD, & S. Chiravuri, MD
Pain Physician; Vol. 11, No. 3, May/June 2008 pp 363-67
Edema Caused by Continuous Epidural Hydromorphone Infusion: A Case Report
And the Review of the Literature
X. Ruan, MD, R.Tadia, MD, H. Liu, MS, J.P.Couch, MD and J.K. Lee, MD, PhD
Journal of Opioid Management; Vol. 4, No. 4, July/August 2008 pp 255-59
A Paradoxical, Novel Approach: Combining Minute Naloxone with Morphine
Intrathecal Infusion
X. Ruan, MD
Journal of Opioid Management; Vol. 4, No. 5, September/October 2008 pp 267
Recurrent Cellulitis Associated with long-term Intrathecal opioid
Infusion Therapy—Case Report
X. Ruan, MD, H. Liu, MS, J.P. Couch, MD, F. Wang, MD and
S. Chiravuri, MD
Pain Medicine 2010 Jun;11(6):972-76
Respiratory Failure-----Following Delayed Intrathecal Morphine
Pump Refill, A Valuable, but Costly Lesson
X. Ruan, MD, J.P. Couch, MD, R. Shah, MD, H. Liu, MS, F. Wang, MD and
S. Chiravuri, MD
Pain Physician 2010 Jul;13(4):337-41
Acute Opioid Withdrawal Following Consumption of Crushed Embeda (Morphine
Extended-Release with Sequestered Naltrexone )--Case report and the focused
Review of the literature.
X. Ruan, MD, T. Chen, MD, Ph.D, J.P. Couch, MD, and S. Chiravuri, MD
Journal of Opioid Management 2010 Jul-Aug;6(4):300-303
Truly a critical review: root cause analysis of paraplegia following transforaminal
Epidural steroid injections: “unsafe” triangle
X. Ruan, MD & S. Chiravuri, MD
Pain Physician 2011 Jan.;14(1):E82-3
Methylnaltrexone: Treatment for opioid-induced constipation: not convinced yet.
H. Liu & X. Ruan, MD
American Journal of Hospice and Palliative Care 2011 March 30. (Epub
Ahead of print)
Urine drug testing in chronic pain.
PJ. Christo, L. Manchikanti, X. Ruan, M. Bottros, H. Hansen, DR. Solanki,
AE. Jordan, J. Colson
Pain Physician. 2011 Mar-Apr:14(2):123-43
Editorial: Sustained-release morphine sulfate with sequestered naltrexone for
moderate to severe pain: a novel opioid analgesic formulation & beyond
X. Ruan, MD
Expert Opinion on Pharmacotherapy 2011 May;12(7):999-1001Epub 2011Apr 7
Current concepts in the management of opioid-induced constipation: A perfect
review with an imperfect concept.
X. Ruan, MD
Journal of Opioid Management 2011 May/June Vol. 7, No. 3 pp 167
Unique low-dose intrathecal opioid trial, still in need of a feasibility check.
X. Ruan, MD & J.P. Couch, MD
Pain Physician. 2011 Sept-Oct.;14(5):E462-3
Feasibility study of rapid opioid rotation and titration: Is it truly feasible or
Paradoxical?
X. Ruan, MD
Pain Physician. 2011 Nov;14(6):571
Editorial: Opioid equianalgesic conversion: How equally analgesic are they?
X. Ruan, MD
Forum of Pain & Rehabilitation. 2012. No. 1:1
Electronic Medical Records: Are we going forwards or backwards?---A perspective
from a private pain practice.
X. Ruan, MD
Pain Physician. 2012 Jan.-Feb.;15(1):99-100
Editorial: Postoperative pain control in patients already on intraspinal drug delivery
for chronic pain: A revisit of the still ignored dilemma.
X. Ruan, MD
Journal of Pain & Relief 2012, Vol. 1, Issue 1;1:1
Successful treatment of intractable low back and pelvic pain caused by advanced
Prostate cancer with intrathecal clonidine and baclofen infusion
H. Liu, MS, H. Chen, MS, X. Ruan, MD
Journal of Pain & Relief 2012, Vol. 1, Issue 3, 1:105
Applaud the novel intrathecal baclofen trialing method: Time to raise the bar!
X. Ruan, MD, & T. Chen, MD, PhD.
Pain Physician 2012 Mar;15(2):E151-E152
Effectiveness of therapeutic lumbar transforaminal epidural steroid injections in
managing lumbar spinal pain.
Maqnchikanti L, RM Buenaventura, KN Manchikanti KN, X. Ruan, S. Gupta,
HS Smith, PJ Christo, SP Ward
Pain Physician. 2012 May-Jun;15(3):E199-245
Commentary: Peripheral edema due to neuraxial opioid infusion: still an
underrecognized predicament
X. Ruan, MD
Agalgesia & Resuscitation: Current Research 2012, 1:1
Letter to the editor: Reexamine the study on abuse potential of Remoxy R : What was
missing?
X. Ruan, MD
Pain Medicine 2013. Jan:14(1):159-60
Novel epidural baclofen infusion trial for intractable spasticity with long-term
Follow-up observation and a focused review of the literature
X. Ruan, MD, T. Chen, MD, G. W.Bumgarner, PhD, J. Hamilton, A. Peavy,
S. Harville, MS, S. Noland, MS, & S. Chiravuri, MD
Journal of Pain & Relief 2013. 2:121
A Five-Star Doctor? Online Rating of Physicians by Patients in an Internet Driven
World: An Editorial
L. Ma, MD, PhD, A.D. Kaye, MD, PhD, M. Bean, MSN, N. Vo, MEd, & X. Ruan,
MD
Pain Physician 2015 Jan-Feb;18(1):E15-E18.
Letter to the Editor: Is There a Paradox Between Opioid-Prescribing by Physicians
and Negative On-Line Ratings by Patients?
X. Ruan, MD, L. Ma, MD, PhD, N. Vo, MEd, & S. Chiravuri, MD
Journal of Opioid Management 2015 Mar-Apr;11(2):108-12
Editorial: The Predicament of the Undertreatment of Chronic Pain and the
Prescription Opioid Epidemic
X. Ruan, MD & S. Chiravuri, MD
Analgesia & Resuscitation: Current Research 2015;4:1
Intractable pruritus during outpatient epidural hydromorphone infusion:
A case report and a focused review of the literature
X. Ruan, MD, L. Ma, MD, PhD, J. P. Couch, MD, T. Chen, MD, PhD,
& G. Bumgarner, PhD
Journal of Opioid Management 2015 March-April:11(2):184-90
Editorial: Clinical Practice Guidelines: the More, the Better?
X. Ruan, MD, L. Ma, MD, PhD, N. Vo, MEd, & S. Chiravuri, MD
North American Journal of Medicine and Sciences 2015;8(2)
Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the
United States: Lessons Learned From OxyContin
X. Ruan, MD, S. Chiravuri, MD, A.D. Kaye, MD, PhD
JAMA Psychiatry 2015 Aug;72(8):849-50
Prescription opioid duration of action and the risk of unintentional overdose among
patients receiving opioid therapy.
X. Ruan, MD, J. Wu, MD, A.D. Kaye, MD, PhD
JAMA Internal Medicine 2015 Sep;175(9):1582-3
Comment on: Patient-Reported Reasons for Emergency Department Visits in the
Urban Medicaid Population.
X. Ruan, MD, A.D. Kaye, MD, PhD.
American Journal of Medical Quality 2015 Sep-Oct;30(5):496.
The Land of the Free.
X. Ruan, MD, J.J. Luo, MD, PhD, A.D. Kaye, MD, PhD
Lancet Psychiatry Vo. 2, Number 7, P588–589, July 2015
Abuse-deterrent formulations: transitioning the pharmaceutical market to improve
public health and safety.
X. Ruan, MD, A.D.Kaye, MD, PhD.
Therapeutic Advances in Drug Safety 2015 Oct;6(5):196-7.
Editorial: The Debate on Urine Drug Testing in Pain and Addiction Management:
Coverage or Non-Coverage?
X. Ruan, MD, A.D.Kaye, MD, PhD,
Journal of Pain & Relief 2015, 4:188
Efficacy of an Acute Pain Titration Protocol Driven by Patient Response to a Simple
Query: Do You Want More Pain Medication?
X. Ruan, MD, A.D.Kaye, MD, PhD
Annals of Emergency Medicine 2015 Dec;66(6):687-8.
Editorial: Off-Label Prescribing, justified or not?
X. Ruan, MD, A.D.Kaye, MD, PhD
American Journal of Medical Quality 2015 Aug 6
Consumption of and satisfaction with health care among opioid users with chronic
non-malignant pain
X. Ruan, MD, A.D.Kaye, MD, PhD
acta anaesthesiologica scandinavica 2015 Aug 18.
Emergency department utilization and subsequent prescription drug overdose death
X. Ruan, A.D. Kaye, MD, PhD
Annals of Epidemiololgy 2015 Nov;25(11):879-80.
The role of participationn sampling and statistical analysis in medical research.
N. Vo, PhD, X. Ruan, MD, A.D. Kaye, MD, PhD
European Journal of Applied Physiology 2015 Sept. 16.
Patient Satisfaction and Short-Term Outcome in Elective Cranial Neurosurgery.
X. Ruan, MD, K. Bydalek, PhD, A.D. Kaye, MD, PhD
Neurosurgery. 2015 Oct. 6
Time to Onset of Sustained Postoperative Pain Relief (SuPPR) Evaluation of a New
Systems-Level Metric for Acute Pain Management
X. Ruan, MD, S. Chiravuri, MD
Clinical Journal of Pain Sept. 28, 2015
Subacute Pain and Persistent Post-Surgical Pain Following Orthopedic Surgery
X. Ruan, MD, S. Chiravuri, MD
Clinical Journal of Pain Oct. 31, 2015
Measuring the Quality of Care for Patients with Traumatic Brain Injury
X. Ruan, MD, A.D. Kaye, MD, PhD
JAMA Surgery 2015 Nov. 18
Saliva versus Plasma for Pharmacokinetic and Pharmacodynamic Studies of
Fentanyl in Patients with Cancer
X. Ruan, MD
Clinical Therapeutics 2015 Nov. 24 Pii: S0149 2918(15)01218
Chronic Opioid Therapy After Lumbar Fusion Surgery for Degenerative Disc
Disease in Workers' Compensation Patients
X. Ruan, MD, A.D. Kaye, MD, PhD
Clinical Journal of Pain 2015 Nov. 26 (Epub)
Emergency Visits for Prescription Opioid Overdose
X. Ruan, MD, A.D. Kaye, MD, PhD
Clinical Journal of Pain 2015 Nov. 26 (Epub)
Nocebo Effect of Informed Consent in Interventional Procedures.
X. Ruan, MD, A.D. Kaye, MD, PhD
Clinical Journal of Pain 2015 Dec. 2 (Epub ahead of print)
Efficiency of an Acute Pain Titration Protocol Driven by Patient Response to a
Simple Query: Do You Want More Pain Medication?
X. Ruan, MD, A.D. Kaye, MD, PhD
Annals of Emergency Medicine 2015 Dec;66(6):687-8
Validity of enriched enrollment, randomized withdrawal trials.
X. Ruan, MD, A.D. Kaye, MD, PhD
Pain. 2016 Jan;157(1):280
Extended-release but Not Immeiate-Release and Subcutaneous Antagonizes the
Loperamide -induced Delay of the Whole-Gut Transit Time in Healthy Subjects
X. Ruan, MD, K. Bydalek, PhD
Journal of Clinical Pharmacology. 2016 Feb;56(2):246-7
Is It Truly the Answer? Personalized Oxycodone Dosing Based on Pharmacogenetic
Testing and the Corresponding Pharmacokinetics.
X. Ruan, MD, L. Ma, MD, PhD, G. Bumgarner, PhD
Pain Medicine 2016 Jan. 11 (Epub ahead of Print)
Deliberate Self-harm Following Bariatric Surgery
X. Ruan, MD, K. Bydalek, PhD, S. Chiravuri, MD
JAMA Surgery. 2016 Jan. 6:1 (Epub ahead of print)
Membership:
The American Society of Interventional Pain Physician (ASIPP)
American Academy of Pain Medicine (AAPM)
American Pain Society (APS)
American Academy of Physical Medicine & Rehabilitation (AAPMR)
American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM)
American Society of Addiction Medicine (ASAM)
Medical Association of the State of Alabama (MASA)
Medical Society of Mobile County (MSMC)
International Institute of Pain & Rehabilitation