1) List the energy sources available to muscle to support exercise. Rank these sources in order of the rate at which they are used to generate ATP.
2) What mechanism regulates the mix of anaerobic and aerobic contributions to exercise?
(The answer may be found in the text.)
3) What is meant by calorie homeostasis?
4) Describe a mechanism for the development of insulin insensitivity and the development of type II diabetes.
5) What is metabolic syndrome?
6) Alcohol metabolism inhibits gluconeogenesis, fatty acid oxidation, and the Krebs cycle. How does it do this?
7) What effect would alcohol metabolism have on glycolysis? Your book says that alcohol consumption can lead to lactic acidosis. Please comments on whether this seems reasonable? What is the normal cause of lactic acidosis?
8) Explain Lipinski’s rules. What is the molecular basis for these rules?
9) How is a partition coefficient determined?
10) What is meant by IC
50
and EC
50
?
11) Explain the two basic approaches to drug discovery.
12) What specific, desirable properties should a compound have to be a good drug?
13) What are the most common pathways for xenobiotic metabolism. Please be specific.
14) What is meant by a metabolic junction? Outline the most important metabolic junctions and diagram how they are related to functional metabolism.
We may not get to these problems for the quiz, but you should certainly think about them for the final…
15) How would you use random combinatorial peptide libraries to select for a peptide with affinity to a specific receptor?
16) Draw the mechanism for cytochrome p450 oxidation.

17) Look up the structures of morphine and codeine. What is the difference between them? What general class of molecules does codeine fall into that morphine does not?
Why is codeine much less potent than morphine? What happens to codeine in the body?
How is morphine metabolized? (Some of these answers are in the book, and some you will have to look up on your own, or figure out!!!!!)
18) Describe the general process used for screening compound libraries to find lead compounds. What is usually done with these lead compounds?