وزارة التعليم العالي جامعة المجمعة كلية العلوم الطبية التطبيقية قسم علوم المختبرات الطبية Ministry of Higher Education Majmaah University College of Applied Medical Sciences Department of Medical Laboratory Lecture 8 Name of Instructor: Dr. Mosaab Omar Location: Majmaah male campus MCQ: Please find the proper answer of the following: 1) Fungi that cause systemic mycoses are: a. Histoplasma capsulatum b. Blastomyces dermatidis c. Paracoccidiodes brasiliensis d. Both A amd C e. All of them 2- Which of the following regardin Coccidioides immitis is true……….. a. is a dimorphic fungus that exists as a mold in soil and as a spherule in tissue b. is a monomorphic fungus that exists as a mold in soil c. is a Monomorphic fungus that exists as a mold in in tissue d. None of them 3- Which of the following regardin Coccidioides immitis is true …………… a- Most people who are infected by C. immitis develop a Humoral immunity. b- Most people who are infected by C. immitis develop a cell-mediated (delayed hypersensitivity) c- No immune response is noticed d- All of them 4- The following statements complies with : Infection of the lungs is often asymptomatic and is evident only by a positive skin test and the presence of antibodies. Some infected persons have influenza like illness with fever and cough. 1 About. 50% have changes in the lungs (infiltrates, adenopathy, or effusions) as seen on chest x-ray. a- Epidemiology of Coccidioide b- Clinical Findings of Coccidioide c- Diagnosis of Coccidioide d- Treatment of Coccidioide 5- Which of the following regarding Paracoccidioides is true …………… a. Unable to ferment sugars, but do assimilate different sugars, inositol and produce urease. b. P. brasiliensis is a dimorphic fungus that exists as a mold in soil and as a yeast in tissue. c. The yeast is thick walled with multiple buds, in contrast to B. dermatidis, which has a single bud d. Both B and C 5- The following regarding Paracoccidioides complies with: The spores are inhaled, and early lesions occur in the lungs. Asymptomatic infection is common. Alternatively oral mucous membrane lesions, lymph node enlargement, and sometimes dissemination to many organs develop. a. Diagnosis of Paracoccidioides b. Treatment of Paracoccidioides c. Epidemiology of Paracoccidioides d. Transmission & Epidemiology of Paracoccidioides 7- Laboratory Diagnosis of Paracoccidioides can be achieved by.……………….. a. In pus or tissues, yeast cells with multiple buds are seen microscopically. b. A specimen cultured for 2-4 weeks may grow typical organisms. c. Skin tests are rarely helpful. d. Serologic testing shows that when significant antibody titers (by immunodiffusion or complement fixation) are found, active disease is present 2 e. All of them 8- The Drug of choice in Treatment of Blastomycosis is ……………….. a. Amphotericin B b. itraconazole c. sulfas or azoles a. Both A and B 9- Diagnosis of cryptococcosis can done by…………………. a. Cutaneous lesions: biopsy with fungal stains and cultures b. Blood: fungal culture, cryptococcal serology, cryptococcal antigen testing and molecular biological assays. c. Cerebrospinal fluid: India ink smear, fungal culture, cryptococcal antigen testing and molecular biological assays. d. Urine and sputum: cultures, even if renal or pulmonary disease is not clinically evident. 3