Step 1
Large cell calcifying Sertoli cell tumor of the testis.
Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a
rare sex cord-stromal tumor that is usually benign. We report on
two cases of LCCSCT of the testis and review the current literature
of this recently described rare subtype of Sertoli cell tumor. A case
of 26-years old Saudi adult presented with painless left testicular
mass and a four and a half year-old Saudi boy presented with left
testicular swelling and precocious puberty. Microscopic
examination of both tumors revealed similar features and shows
clusters or cords of large, non-mitotic, sertoli cells with abundant
eosinophilic cytoplasm and extensive foci of calcification tumor
cells. Both tumors expressed cytokeratin and vimentin and weak
expression for inhibin. Ki-67 and p53 protein are negative.
Ultrastructural examination indicated features common to steroidproducing cells. The first patient treated by tumorectomy and the
second by transinguinal radical orchidectomy. Both patients are in
a good health after a follow-up period of 3 and 1 year respectively
with no evidence of recurrence or metastasis. These reports appear
to be the first Saudi cases of LCCSCT.
PMID: 16270775 [PubMed - indexed for MEDLINE]
Ann Saudi Med.
25
5
2005 Sep-Oct
436-7
‫عنوان الوثيقة‬
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Step 2
Jaudah
Al-Maghrabi
Department of Pathology, King Abdulaziz University Hospital, PO Box 80215,
Jeddah 21589, Saudi Arabia
jalmaghrabi@hotmail.com
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