Body Systems DR NILOFER A R A S S I S TA N T P R O F E S S O R I N O B G FA C U LT Y O F M E D I C I N E . Respiratory System The respiratory system is composed of various structures and organs ensuring that the body is able to maintain its internal environment through the exchange of air between the lungs and the atmosphere. Respiratory System In order to survive the body needs a constant supply of oxygen, which it obtains from the air. The body also needs to dispose of carbon dioxide, made as a waste product from the process of cell metabolism. respiratory system The ingestion of oxygen and the discarding of carbon dioxide occurs through the process of respiration or breathing. The function of the respiratory system is to supply oxygen and to remove carbon dioxide from cells. Oxygen is needed by cells to produce heat and energy. In using oxygen, the cells produce carbon dioxide as waste. respiratory system Inhaled air is moistened and warmed as it passes through the upper respiratory tract - the nose, the pharynx and the larynx. The clean air passes on through the lower respiratory tract - the trachea and lungs where the exchange of gases takes place. respiratory system Structure The respiratory system is comprised of the: Upper respiratory system: nose mouth Larynx Lower respiratory system: pharynx trachea bronchus lungs. respiratory system Summary: The main organ of the respiratory system is the lungs. Our lungs breathe in oxygen and breathe out carbon dioxide. This exchange of gases is vital to life. respiratory system Breathing depends on the diaphragm, a sheet of muscle slung beneath the lungs inside the ribcage. Common problems of the respiratory system include asthma, bronchitis, emphysema, hay-fever, influenza, laryngitis and pneumonia. respiratory system Asthma – wheezing and breathlessness caused by a narrowing of the airways Bronchitis – inflammation of the lung’s mucous lining Emphysema – disease of the alveoli Hay-fever – an allergic reaction to pollen, dust or other irritants Influenza – caused by viruses Laryngitis – inflammation of the vocal cords (larynx) Pneumonia – inflammation of the lung. Cardiovascular system The Heart The heart is a muscular pumping organ located medial to the lungs along the body’s midline in the thoracic region. The bottom tip of the heart, known as its apex, is turned to the left, so that about 2/3 of the heart is located on the body’s left side with the other 1/3 on right. The top of the heart, known as the heart’s base, connects to the great blood vessels of the body: the aorta, vena cava, pulmonary trunk, and pulmonary veins. Cardiovascular system Circulatory Loops There are 2 primary circulatory loops in the human body: the pulmonary circulation loop the systemic circulation loop. Other loops: Coronary Circulation Hepatic Portal Circulation Cardiovascular system Pulmonary circulation transports deoxygenated blood from the right side of the heart to the lungs, where the blood picks up oxygen and returns to the left side of the heart. The pumping chambers of the heart that support the pulmonary circulation loop are the right atrium and right ventricle. Cardiovascular system Systemic circulation carries highly oxygenated blood from the left side of the heart to all of the tissues of the body (with the exception of the heart and lungs). Systemic circulation removes wastes from body tissues and returns deoxygenated blood to the right side of the heart. The left atrium and left ventricle of the heart are the pumping chambers for the systemic circulation loop. Cardiovascular system Blood Vessels : 1- Arteries and Arterioles 2- Capillaries: Capillaries are the smallest and thinnest of the blood vessels in the body and also the most common. 3- Veins and Venules: Veins are the large return vessels of the body and act as the blood return counterparts of arteries. Cardiovascular system Blood The average human body contains about 4 to 5 liters of blood. As a liquid connective tissue, it transports many substances through the body and helps to maintain homeostasis of nutrients, wastes, and gases. Blood is made up of red blood cells, white blood cells, platelets, and liquid plasma. Cardiovascular system 1)Red Blood Cells 2) White Blood Cells a-granular leukocytes--neutrophils, eosinophils, and basophils 2- a granular leukocytes--lymphocytes and monocytes 3) Platelets 4) Plasma---water, proteins Cardiovascular system Cardiovascular System Physiology: The cardiovascular system has three major functions: transportation of materials, protection from pathogens, and regulation of the body’s homeostasis. Cardiovascular system Transportation: The cardiovascular system transports blood to almost all of the body’s tissues. The blood delivers essential nutrients and oxygen and removes wastes and carbon dioxide to be processed or removed from the body. Hormones are transported throughout the body via the blood’s liquid plasma. Cardiovascular system Protection: The cardiovascular system protects the body through its white blood cells. White blood cells clean up cellular debris and fight pathogens that have entered the body. Platelets and red blood cells form scabs to seal wounds and prevent pathogens from entering the body and liquids from leaking out. Blood also carries antibodies that provide specific immunity to pathogens that the body has previously been exposed to or has been vaccinated against. Cardiovascular system Regulation: The cardiovascular system is instrumental in the body’s ability to maintain homeostatic control of several internal conditions. Blood vessels help maintain a stable body temperature by controlling the blood flow to the surface of the skin. Blood vessels near the skin’s surface open during times of overheating to allow hot blood to dump its heat into the body’s surroundings. In the case of hypothermia, these blood vessels constrict to keep blood flowing only to vital organs in the body’s core. Blood also helps balance the body’s pH due to the presence of bicarbonate ions, which act as a buffer solution. Finally, the albumins in blood plasma help to balance the osmotic concentration of the body’s cells by maintaining an isotonic environment. Skeletal System The skeletal system in an adult body is made up of 206 individual bones. These bones are arranged into two major divisions: the axial skeleton the appendicular skeleton. Skeletal System The axial skeleton runs along the body’s midline axis and is made up of 80 bones in the following regions: Skull Hyoid Auditory ossicles Ribs Sternum Vertebral column Skeletal System The appendicular skeleton is made up of 126 bones in the folowing regions: Upper limbs Lower limbs Pelvic girdle Pectoral (shoulder) girdle Skeletal System Skeletal System Physiology Support and Protection: The skeletal system’s primary function is to form a solid framework that supports and protects the body's organs and anchors the skeletal muscles. The bones of the axial skeleton act as a hard shell to protect the internal organs—such as the brain and the heart—from damage caused by external forces. The bones of the appendicular skeleton provide support and flexibility at the joints and anchor the muscles that move the limbs. Skeletal System Movement The bones of the skeletal system act as attachment points for the skeletal muscles of the body. Almost every skeletal muscle works by pulling two or more bones either closer together or further apart. Joints act as pivot points for the movement of the bones. The regions of each bone where muscles attach to the bone grow larger and stronger to support the additional force of the muscle. In addition, the overall mass and thickness of a bone increase when it is under a lot of stress from lifting weights or supporting body weight. Skeletal System Hematopoiesis Red bone marrow produces red and white blood cells in a process known as hematopoiesis. Red bone marrow is found in the hollow space inside of bones known as the medullary cavity. Children tend to have more red bone marrow compared to their body size than adults do, due to their body’s constant growth and development. The amount of red bone marrow drops off at the end of puberty, replaced by yellow bone marrow. Skeletal System Storage The skeletal system stores many different types of essential substances to facilitate growth and repair of the body. The skeletal system’s cell matrix acts as our calcium bank by storing and releasing calcium ions into the blood as needed. Proper levels of calcium ions in the blood are essential to the proper function of the nervous and muscular systems. Bone cells also release osteocalcin, a hormone that helps regulate blood sugar and fat deposition. The yellow bone marrow inside of our hollow long bones is used to store energy in the form of lipids. Finally, red bone marrow stores some iron in the form of the molecule ferritin and uses this iron to form hemoglobin in red blood cells.