AbstractID: 8545 Title: Mechanical evaluation of a CT/linac therapy system The purpose of this study was to characterize the mechanical accuracy and precision of a new CT/linac therapy system. The layout of this system is such that after the patient is positioned for treatment under the linac, the couch can be rotated through 180 degrees for CT scanning. Translations in the vertical or transverse directions may be needed for alignment with the CT scanner aperture. The entire CT gantry then moves on rails across the patient to acquire an image set. Ultimately, this CT image set will be used to determine, and correct for, the patient’s position and anatomy relative to that of the treatment planning image set. Five mechanical sources of variation in the relationship between the radiotherapy isocenter and CT isocenter were identified and investigated: couch position at the linac side after a rotation, couch position at the CT side after a rotation, couch position as given by the digital readouts, effect of couch flexibility, and reported CT coordinates. With the exception of couch flexibility, all were found to have standard deviations of 0.5mm or less. The couch was found to flex vertically by more than 1mm, but the difference in flex between the linac side and CT side was found to be less than 1mm. Alignment protocols can be compared by quadrature addition of the appropriate variations. The results will be used in the development of reliable and effective localization and treatment protocols.