Universidade Nacional da Irlanda em Galway -- Ciência sem Fronteiras PhD Project Template Use one form per project Please complete & submit to international@nuigalway.ie as soon as possible, and by 27/11/2012 In your email, begin the subject line with [SWB] (be sure to use square brackets) to ensure that your email is filed correctly. Emails will be automatically filed PI name & contact details: Dr Karen Doyle School: Medicine Has project been agreed with head (or nominee) of proposed registration school? Research Centre / group affiliation: Neuroscience Cluster, NUI Galway Research group / centre website: http://www.nuigalway.ie/physiology/karen_doyle.html PI website / link to CV: http://www.nuigalway.ie/our-research/people/medicine/karendoyle/ Brief summary of PI research / research group / centre activity (2 or 3 lines max): If you are already involved in relevant scholarly activities relating to Brazil, please mention them here. Cell stress and neuroprotection. Broadly, my interest lies in understanding the pathological changes in the brain underpinning the development of neurological and psychiatric disorders, and investigating ways to convey neuroprotection, which may help to prevent or treat these diseases. Title & brief description of PhD project (suitable for publication on web): Investigation of the involvement of polyamines in the pathophysiology of stroke Stroke is the third highest cause of mortality and the greatest cause of disablement in the Western World. At present, there is a marked lack of effective treatments to reduce the extent of brain damage once a stroke is in evolution. Polyamines are widely distributed in brain tissue, and it is possible that they may play a role in the pathophysiology of stroke, perhaps through modulation of NMDA receptor activation and subsequently, cell death. It is the aim of this project to clarify the involvement of the polyamines in the pathophysiology of stroke and to explore their therapeutic potential. Universidade Nacional da Irlanda em Galway -- Ciência sem Fronteiras Unique selling points of PhD project in NUI Galway: NUI Galway projects should emphasise features that are not typically available in Brazil – specific equipment, multi-disciplinarity, aspects of structured programme, links with industry, placements, links with other research groups etc. The student researcher will become part of the vibrant Neuroscience community in NUI, Galway and his/her career development will benefit from the stimulating multidisciplinary research environment. State of the art facilities and equipment are avialable to facilitate Neuroscience research in NUI, Galway. The student will enroll in a structured PhD programme in the College of Medicine, Nursing and Health Sciences, NUI Galway, which will enable them to gain credit for attending courses of added benefit to their development as a researcher. The breadth of experience the student will gain will equip them to develop as an independent researcher. Name & contact details for project queries, if different from PI named above: Please indicate the graduates of which disciplines that should apply: Anatomy, Biochemistry, Physiology, Pharmacology, Medicine, Pharmacy Ciência sem Fronteiras / Science Without Borders Priority Area: Please indicate the specific programme priority area under which the proposed PhD project fits- choose only one (tick box): Engineering and other technological areas Pure and Natural Sciences (e.g. mathematics, physics, chemistry) Health and Biomedical Sciences x Information and Communication Technologies (ICTs) Aerospace Pharmaceuticals Oil, Gas and Coal Renewable Energy Minerals Biotechnology Nanotechnology and New Materials Technology of prevention and remediation of natural disasters Biodiversity and Bioprospection Marine Sciences Creative Industry New technologies in constructive engineering Please indicate which of the following applies to this project (referring to Science Without Borders arrangements): Universidade Nacional da Irlanda em Galway -- Ciência sem Fronteiras Suitable only as a Full PhD (Y/N): _ __Y__ Available to candidates seeking a Sandwich PhD arrangement (Y/N): __Y___ Suitable for either/Don’t know: __Y___