AbstractID: 6886 Title: Comparison of Leaf Sequencing Algorithms Against the Efficient Frontier of Monitor Unit and Segment Usage Different algorithms have been devised to create the sequence of leaf positions (or segments) that will generate a desired intensity map with static field IMRT. The goal has been to use fewer monitor units and segments in order to reduce machine leakage and treatment time. None of the published methods minimizes the number of segments for a given number of monitor units. This study investigates the excess number of monitor units and segments produced by competing leaf sequencing algorithms. Tests were performed using random maps to remove selection bias and permit any available algorithm to be evaluated. Tests of three algorithms are reported here. One, credited to Bortfeld, minimizes monitor units. The other two, called areal and reducing, aim to decrease segment number at the price of an increased number of monitor units. An integer program was used to find the minimum number of segments needed to complete a sequence with the minimum number of monitor units. By allowing bidirectional leaf movement, the number of segments can be reduced >140% from the unidirectional sequence provided by the Bortfeld algorithm without requiring more monitor units. The bidirectional sequences of the areal and reducing algorithms exceed the minimum number of monitor units by >24%, yet still use >35% more segments than needed by sequences expending the minimum number of monitor units found by the integer program. The shortfall of any future algorithm can be measured by comparing solutions using against the optima found by the integer program.