AbstractID: 9428 Title: Practical Quality Assurance of the Automatic Positioning System on the Leksell Gamma Knife We present a practical scheme for commissioning and routine quality assurance (QA) of the Leksell Gamma Knife automatic positioning system (APS) using an economical, novel radiographic-film phantom. The phantom is CT and Leksell-frame compatible. QA procedures involve imaging, planning and treatment with the APS, allowing assessment of cumulative and relative positioning uncertainties for these functions. The QA phantom consists of two light-tight polystyrene plastic cassettes (designed to hold radiographic film) mounted on a Lucite plate, mated to a Leksell positioning head frame. Initially, a treatment plan is designed (based on a CT scan of the phantom and frame) to irradiate select, individual points in the film planes. Multiple points are identified from the CT scan. Irradiation is then planned and conducted via two distinct shots on each point. The two shots per irradiation point vary in collimator size and one of the following parameters: gamma angle, different docking position (using APS extenders) and/or APS versus trunnion mode. Variations in the center of each shot on the same interest point on a film plane represent a precision margin associated with the underlying parameter that was varied. Accuracy is determined from distance measurements of three pins, which puncture and fix film in the phantom, to the center of the irradiation points. Absolute errors in positioning were found to be ≤ 0.5 mm, while the precision measured for the APS was ≤ 0.3 mm.