NASA HUMAN RESEARCH PROGRAM INVESTIGATORS’ WORKSHOP February 3-5, 2010, Houston, Texas STEERING COMMITTEE
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NASA HUMAN RESEARCH PROGRAM INVESTIGATORS’ WORKSHOP February 3-5, 2010, Houston, Texas STEERING COMMITTEE Maneesh Arya, Ph.D. Barbara J. Corbin Craig E. Kundrot, Ph.D. Jeffrey P. Sutton, M.D., Ph.D. John B. Charles, Ph.D. Dennis J. Grounds Adrian D. LeBlanc, Ph.D. David A. Watson, Ph.D. LOGISTICS COMMITTEE Terri Jones, Workshop Coordinator Dana Nelson Gail Pacetti Kellie Rogers Dagmar Morgan Kay Nute Lori Pedersen SESSION CHAIRS Behavioral Health and Performance Behavioral Medicine Team, Sleep David Dinges, Ph.D., Lauren Leveton, Ph.D. George Brainard, Ph.D., Camille Shea, Ph.D. Education and Outreach Charles Lloyd, Pharm.D., William Thomson, Ph.D. Exploration Medical Capability David Baumann, Babs Soller, Ph.D., Sharmila Watkins, M.D. Human Health and Countermeasures Bone Cardiovascular Extravehicular Activity (EVA) Immunology Muscle Thomas Lang, Ph.D., Jean Sibonga, Ph.D. Steven Platts, Ph.D. Michael L. Gernhardt, Ph.D. Brian Crucian, Ph.D. Lori Ploutz-Snyder, Ph.D., Jeffrey Ryder, Ph.D. Scott Smith, Ph.D., Sara Zwart, Ph.D. Jacob Bloomberg, Ph.D., Charles Oman, Ph.D. Nutrition Sensorimotor Space Human Factors and Habitability Space Human Factors Engineering Advanced Food Technology/Advanced Environmental Health Janis Connolly, M.Arch., Mary Kaiser, Ph.D. Michele Perchonok, Ph.D., Mark Ott, Ph.D. Space Radiation Cancer CNS, Degenerative, and Acute Risks Jerry Shay, Ph.D., Honglu Wu, Ph.D. Janice Huff, Ph.D., Ann Kennedy, Ph.D. 1 Table of Contents Title Page ..............................................................................................................1 Table of Contents ..................................................................................................2 Program Synopsis .................................................................................................3 Plenary and Breakout Session Room Assignments ..............................................6 Wednesday Plenary Sessions...............................................................................7 Student Poster Exhibition and Competition ...........................................................8 Thursday Plenary Sessions...................................................................................9 Thursday Science Discipline Session I Behavioral Health and Performance I B-Med ..........................................12 Education Outreach..................................................................................13 Exploration Medical Capability I................................................................16 Human Health and Countermeasures Integrated Plenary ........................17 Immunology ..............................................................................................18 Muscle ......................................................................................................19 Nutrition ....................................................................................................20 Space Human Factors and Habitability I ..................................................21 Space Radiation I Cancer........................................................................22 Thursday Science Discipline Session II Behavioral Health and Performance II Team, Sleep................................23 Bone .........................................................................................................24 Cardiovascular..........................................................................................25 Exploration Medical Capability II...............................................................26 Extravehicular Activity ..............................................................................27 Sensorimotor ............................................................................................28 Space Human Factors and Habitability II .................................................29 Space Radiation II CNS, Degenerative, Acute Risks...............................30 Thursday Poster Session Behavioral Health and Performance.........................................................31 Exploration Medical Capability..................................................................31 Human Health and Countermeasures ......................................................32 NSBRI Postdoctoral Fellows.....................................................................32 Space Human Factors and Habitability ....................................................34 Space Radiation .......................................................................................34 Friday New Talent Showcase..............................................................................37 Author Index........................................................................................................38 National Aeronautics and Space Administration Lyndon B. Johnson Space Center Houston, Texas 77058 Universities Space Research Association Division of Space Life Sciences 3600 Bay Area Boulevard Houston, Texas 77058 USRA DSLS operates under Cooperative Agreement NNJ06HG25A with the National Aeronautics and Space Administration 2 PROGRAM SYNOPSIS Tuesday, February 2, 2010 4:00-8:00 Early Registration 4:00-8:00 Galleria Foyer Poster Set-up West Alabama and Chevy Chase Wednesday, February 3, 2010 7:30 Registration Galleria Foyer 8:00 Welcome, Greeting, Workshop Overview and HRP Update (D. Grounds, B. Neumann, J. Sutton, J. Charles) Galleria I and II 9:00 Special Human Research Program Needs for 2010: Flight Mission Opportunities (J. Charles, C. Sams) Galleria I and II 10:00 Break Galleria Foyer Student Poster Exhibition Galleria Foyer 10:30 Laurence R. Young Award (L. Young) Galleria I and II 10:40 Human Research-Relevant Aspects of the Augustine Report and Subsequent Administration Decisions (L. Chiao) Galleria I and II 11:00 Update on Human Research Program Processes: Risk Board – How to Present a New Risk (B. Corbin, M. Ott) Galleria I and II 11:30 Lunch Plaza Ballroom 1:00 Bridging the Great Divide: Transitioning Work from Research to Operations (D. Watson, L. Chiao, D. Larson, J.D. Polk, K. Johnson-Throop, B. Soller) Galleria I and II 3:00 Break Galleria Foyer 3:30 Human Research Program Roadmap Update and Data Accessibility (E. Bauer, K. Johnson-Throop, C. Sams) Galleria I and II 4:00 Non-Human Research in HRP: Strategy and Schedule (J. Smith, R. Globus, V. Caiozzo, D. Berkowitz, J. Meck) Galleria I and II 5:00 Recaps and Wrap-ups: Q&A Session with Day’s Presenters Galleria I and II 3 5:30 Wednesday Plenary Sessions Adjourn Galleria I and II 5:30 Student Poster Judging Galleria Foyer 5:30 Animal Research Workshop Panel (J. Meck, R. Globus, J. Smith, D. Berkowitz, V. Caiozzo) Galleria I and II 7:30 Animal Research Workshop Adjourns Galleria I and II Thursday, February 4, 2010 7:30 Registration Galleria Foyer Student Poster Exhibition Galleria Foyer 8:00 Habitability Design for Science (J. Connolly, C. Conlee, L. Toups, N. Currie) Galleria I and II 9:00 The Ground-to-Space Pathway: Behavioral Health and Performance Element’s Optimal Utilization Strategy for Space Analogs (L. Leveton, K. Keeton, C. Otto, M. Reagan, D. Dinges, L. Barger, O. Angerer) Galleria I and II 10:10 Break Galleria Foyer 10:30 NSBRI Pioneer Award (J. Sutton) Galleria I and II 10:40 Non-Microgravity Provocations to Crew During Spaceflight (L. Leveton, S. Johnston, E. Kerstman, W. Sipes, M. Perchonok, C. Allen, V. Wotring) Galleria I and II 11:40 Lunch Plaza Ballroom 1:00 Discipline-Specific Session I All Rooms 3:15 Break Galleria Foyer 3:45 Discipline-Specific Session II All Rooms 6:00 Poster Session West Alabama, Chevy Chase 8:00 Poster Session Adjourns and Poster Removal Friday, February 5, 2010 8:00 New Talent Showcase (S. Kozlowski, E. Salas, K. Duda, M. Cooper, W. 4 Galleria I and II Wallace, J. Dziegielewski, C. Westby) 10:00 Break Galleria Foyer 10:30 USRA Young Investigator Award (A. LeBlanc) Galleria I and II 10:40 Student Poster Recognition (D. Watson) Galleria I and II 10:50 New Talent Showcase (J. Ritter, A. Weaver) Galleria I and II 11:45 Closing Remarks (D. Grounds, J. Charles) Galleria I and II 12:00 Adjourn (Boxed lunches to go) Galleria Foyer 5 NASA Human Research Program Investigators’ Workshop February 3 - 5, 2010 Plenary and Breakout Session* Room Assignments Wednesday, February 3, 2010 Galleria I/II Galleria III Bellaire Plaza Post Oak Sage Tanglewood Westchester Bellaire Plaza Post Oak Sage Tanglewood Westchester Plenary Sessions 8:00 - Noon Plenary Sessions 1:00 – 5:30 Animal Research Workshop 5:30 – 7:30 Thursday, February 4, 2010 Galleria I/II Galleria III Plenary Sessions 8:00 - Noon HHC Integrated Plenary 1:00-2:00 Muscle 2:00 – 3:30 Bone 3:45 – 5:45 Education Outreach 1:00 – 3:15 SHFH I SHFE 1:00 – 3:15 Nutrition 2:00 – 3:30 SR I - Cancer 1:00 – 3:15 BHP I B-Med 1:00 – 3:15 Immunology 2:00 – 3:30 ExMC I 1:00 – 3:15 Sensorimotor 3:45 – 5:45 SHFH II AVT/AEH 3:45 – 5:45 Cardio 3:45 – 5:45 SR II - CNS, Degenerative, Acute Risks 3:45 – 5:45 BHP II Team, Sleep 3:45 – 5:45 EVA 3:45 -5:45 ExMC II 3:45 -5:45 Friday, February 5, 2010 Galleria I/II Galleria III Bellaire Plaza Post Oak New Talent Plenary 8:00 - Noon *Breakout Session Acronyms: BHP Behavioral Health and Performance B-Med Behavioral Medicine ExMC Exploration Medical Capability HHC Human Health and Countermeasures EVA Extravehicular Activity SHFH Space Human Factors and Habitability SHFE Space Human Factors Engineering AVT Advanced Food Technology AEH Advanced Environmental Health SR Space Radiation 6 Sage Tanglewood Westchester WEDNESDAY PLENARY SESSIONS Wednesday, February 3, 2010 8:00 a.m. – 5:30 p.m. Galleria Ballroom I and II 8:00 Dennis Grounds, Benjamin Neumann, Jeffrey P. Sutton, M.D., Ph.D., John Charles, Ph.D. Welcome, Greeting from Exploration Systems Mission Directorate, Workshop Overview, and Human Research Program Update 9:00 John Charles, Ph.D., Clarence Sams, Ph.D. Special Human Research Program Needs for 2010: Flight Mission Opportunities 10:00 Break (Galleria Foyer) 10:30 Laurence R. Young, Sc.D. 2010 Laurence R. Young Space Biomedical Research Award 10:40 Leroy Chiao, Ph.D. Human Research-Relevant Aspects of the Augustine Report and Subsequent Administration Decisions 11:00 Barbara Corbin, Mark Ott, Ph.D. Update on Human Research Program Processes: Risk Board – How to Present a New Risk 11:30 Lunch (Plaza Ballroom) 1:30 Panel: Bridging the Great Divide: Transitioning Work from Research to Operations Introductions and Overview David Watson, Ph.D., Panel Chair, NSBRI Operational Countermeasure: A User Perspective Leroy Chiao, Ph.D., Chair, NSBRI User Panel, Former Astronaut Research to Operations Outside NASA Dale Larson, Ph.D., Director of Biomedical Engineering, Draper Labs Implementation of Research into Medical Practice J.D. Polk, M.D., Kathy Johnson-Throop, Ph.D., Johnson Space Center Hardware Development Challenges and Successes Babs Soller, Ph.D., University of Massachusetts 3:00 Break (Galleria Foyer) 3:30 Panel: Human Research Program Roadmap Update and Data Accessibility Elizabeth Bauer, Kathy Johnson-Throop, Ph.D., Clarence Sams, Ph.D. 4:00 Panel: Non-Human Research in HRP: Strategy and Schedule Introduction: Jeffrey D. Smith, Ph.D., Ames Research Center Animal Research for Space flight: Integrated Physiology and Experimental Approaches Ruth Globus, Ph.D., Ames Research Center For Every Inaction There Is a Reaction: Newton’s Fourth Law and Muscle Plasticity Vincent Caiozzo, Ph.D., University of California Irvine Translational Science in Space Biology: What We Can Learn From Animal Models Dan Berkowitz, Ph.D., Johns Hopkins Medicine 7 Concluding Comments Janice Meck, Ph.D., Johnson Space Center 5:00 Recaps and Wrap-Ups: Q&A Session with the Day’s Presenters 5:30 Wednesday Plenary Sessions Adjourn 5:30 Student Poster Judging 5:30 Animal Research Workshop Panel Janice Meck, Ph.D., Ruth Globus, Ph.D., Jeffrey Smith, Ph.D., Dan Berkowitz, Ph.D., Vince Caiozzo Ph.D. Questions and Answers from the Plenary Session Comments by Human Health and Countermeasures Discipline Leads Open Discussion of Key Questions 7:30 Animal Research Workshop Adjourns STUDENT POSTER EXHIBITION AND COMPETITION Wednesday and Thursday, February 3 and 4, 2010 8:00 a.m. – 5:30 p.m. Galleria Foyer Response of Staphylococcus aureus to a Spaceflight Analogue Sarah Castro, University of Texas Medical Branch Weight Bearing in Simulated 1/6th and 1/3rd Gravity Does Not Prevent Cancellous Bone Loss Brandon Macias, Texas A&M University Molecular and Histopathological Changes in Mouse Intestinal Tissue after Proton Exposure Ashley Purgason, University of Texas Medical Branch Defining the Job of an Astronaut Via a Creative Job Analysis Technique Cristina Rubino, University of Houston Osteocytes Mechanosensing in NASA Rotating Wall Bioreactor Jordan Spatz, Massachusetts Institute of Technology Alendronate Inhibits Bone Formation Response to Simulated Resistance Training During Disuse Joshua Swift, Texas A&M University The Dendro[C60]fullerene DF-1 Provides Potent Radioprotection Against The Biological Effects Of Ionizing Radiation In Mammalian Cells Corey Theriot, NASA Postdoctoral Fellow/ NASA Johnson Space Center/ Oak Ridge Associated Universities Team Performance during Long-duration Assignment: A Conceptual Framework Sallie Weaver, University of Central Florida 8 THURSDAY PLENARY SESSIONS Thursday, February 4, 2010 8:00 a.m. – 11:40 a.m. Galleria Ballroom I and II 8:00 Panel: Habitability Design for Science Introduction Janis Connolly, Space Human Factors Engineering Project Manager, Johnson Space Center Living and Conducting Science in Space Nancy Currie, Ph.D., Chief Engineer, NASA Engineering and Safety Center, Johnson Space Center, Former Astronaut Design for Science Carl Conlee, Habitability Design Center, Johnson Space Center Lunar Surface Systems Design and Science Larry Toups, Constellation Lunar Surface Systems Project, Johnson Space Center Discussion & Questions 9:00 Panel: The Ground-to-Space Pathway: Behavioral Health and Performance Element’s Optimal Utilization Strategy for Space Analogs Panel Overview Lauren Leveton, Ph.D., BHP Element Manager, Johnson Space Center Analog Assessment Tool: Kathryn Keeton, Ph.D., Wyle Life Sciences Antarctica as an Analog for a Mars Mission Christian Otto, M.D., University of Ottawa NEEMO: Using an Undersea Space Analog for Mission Risk Reduction Marc Reagan, Mission Operations, Johnson Space Center A Critical Role for Analogs in the Development of the PVT Self Test for Fatigue Management in Space David Dinges, Ph.D., University of Pennsylvania School of Medicine Validating Countermeasures in Operational Analogs Laura Barger, Ph.D., Brigham and Women’s Hospital Brief Report on an International Workshop on Human Behavior and Performance in Analogues and Simulations Oliver Angerer, Ph.D., Human Exploration Science Coordinator, ESA/ESTEC 10:10 Break (Galleria Foyer) 10:30 Jeffrey P. Sutton, M.D., Ph.D. NSBRI Pioneer Award 10:40 Panel: Non-Microgravity Provocations to Crew During Spaceflight Panel Overview Lauren Leveton, Ph.D., BHP Element Manager, Johnson Space Center Operational Stressors: Slam Shifting, Sleep Meds, Training, and Workload Stressors Smith Johnston, M.D., Flight Surgeon, Johnson Space Center Skin Rashes on Space Flights Eric Kerstman, M.D., MPH, Advanced Projects Clinical Systems Physicians, University of Texas Medical Branch/Wyle An Operational Perspective on Spaceflight Behavioral Stressors Walter Sipes, Ph.D., Aerospace Psychologist, Johnson Space Center 9 There Is More to Food Than Just Nutrition: The Effect of Food Quality on the Crew’s Psychological WellBeing Michele Perchonok, Ph.D., Project Manager, Advanced Food Technology, Johnson Space Center Acoustic Environments and Noise Control in Spacecraft Vehicles Christopher Allen, Ph.D., Johnson Space Center Pharmacological Issues for Astronauts Virginia Wotring, Ph.D., USRA Division of Space Life Sciences 11:40 Lunch (Plaza Ballroom) 10 THURSDAY AFTERNOON AND EVENING SESSIONS Thursday, February 4, 2010 1:00 p.m. – 8:00 p.m. All Rooms 1:00 - 3:15 p.m. Discipline-Specific Session I (Galleria I / II, Galleria III, Bellaire, Plaza, Post Oak, Sage, Tanglewood, Westchester) 3:15 Break (Galleria Foyer) 3:45 - 5:45 p.m. Discipline-Specific Session II (Galleria I / II, Galleria III, Bellaire, Plaza, Post Oak, Sage, Tanglewood, Westchester) 6:00 - 8:00 p.m. Poster Session (West Alabama, Chevy Chase) 8:00 Poster Removal 11 Thursday, February 4, 2010 BEHAVIORAL HEALTH AND PERFORMANCE I -- B-MED 1:00 p.m. – 3:15 p.m. Sage Room Chairs: David Dinges, Ph.D. Lauren Leveton, Ph.D. *Presenter 1:00 Leveton L.* Behavioral Health and Performance Overview 1:15 Stuster J.* Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals 1:30 Dinges D. F.* Metaxas D. Banks S. Goel N. Ecker A. Basner M. Overview of NSBRI Neurobehavioral and Psychosocial Projects Involving Detection and Mitigation Stress, Fatigue and Conflict in Space [Abstract #1085] 2:00 Strangman G. E.* Zhang Q. Supelana C. S. Zeffiro T. A. Objective Detection, Evaluation and Countermeasures for In-flight Depression [Abstract #1110] 2:15 Rose R. D.* Buckey J. C. Jr. Craske M. G. Cartreine J. A. SMART-OP: Stress Management and Resilience Training for Optimal Performance On Long Duration Missions [Abstract #1100] 2:30 Cartreine J. A. Hegel M. T. Locke S. E. Buckey J. C.* Self-administered Treatment of Depression via Interactive Media: A Pilot Study [Abstract #1121] 2:45 Discussion 12 Thursday, February 4, 2010 EDUCATION OUTREACH SCIENCE EDUCATION, THE ENDLESS FRONTIER 1:00 p.m. – 3:15 p.m. Galleria Ballroom III Chairs: Charles Lloyd, Pharm.D. William Thomson, Ph.D. SESSION THEME: Advancing STEM Education Across the Educational Continuum: Telling the Story of Human Challenges of Space Exploration. Over the past 15 years, teams of NASA and NSBRI educators have engaged in Science, Technology, Engineering, and Mathematics (STEM) education outreach to communicate the significance and excitement of space life sciences to local, national and international audiences. These teams have translated and disseminated knowledge gained through biomedical advances achieved by NASA and NSBRI scientists via a wide range of educational programs and activities targeting teachers, students and practitioners across the educational continuum, as well as the general public. Multiple strategies have been applied to encourage and engage learners, always with the goal of producing the next generation of space life scientists. These approaches include professional development, curriculum development, graduate training programs, postdoctoral fellowships, online graduate resources, summer research internships, web-based K-16 resources, informal space-life sciences education for the general public, and international education outreach. This year’s Human Research Program Education and Outreach (E&O) plenary session will showcase an Education Programs and Products Fair informs participants of our E&O programs. NASA and NSBRI-funded E&O efforts are dedicated to utilize human research program knowledge and information to develop and implement new educational content for teachers and students, in both formal and informal educational environments; engage learners of all ages; and capitalize upon the benefits of different social media to promote distribution of the materials to educators, students and the general public. Attendees will view and use materials and activities created for classrooms, and learn new approaches for communicating NASA’s contributions to STEM education. Sample products will be freely available. Exhibits will include 1) primary school content in inquiry-based science curricula and materials for formal and informal science environments, 2) secondary educational content and programs, 3) summer experiences for students, 4) graduate and postgraduate education programs in bioastronautics and space life sciences, 5) science education activities and ISS, and 6) outreach to the general public. 1:00 1:15 Lloyd C. Thomson W. Session Overview and Update on the NASA Human Research Program Education and Outreach (HRPEO) and NSBRI Current Activities Lloyd C. Thomson W. Introductory statements on each table-top station and display and begin the session Judith Hayes, Deputy Chief, NASA Human Adaptation and Countermeasures Division; Gabe Rieger, SLSSI Coordinator Space Life Sciences Summer Institute The Space Life Sciences Summer Science is open to all interns and fellows participating in life science activities at JSC, GRC and, in 2010, ARC. Each student is assigned a mentor within the NASA biomedical laboratories and participates in ongoing research. To enhance their NASA experience, the Institute offers lectures and tours throughout the summer to expose the students to various aspects of human space flight. The faculty includes: astronauts, scientists, engineers, flight surgeons, flight directors, and NASA administrators. In addition to the lecture series, the Institute provides behind-the-scene tours of the Neutral Buoyancy Laboratory, Mission Control Center, Shuttle and Space Station training mock-ups as well as a hands-on demonstration of the Advance Crew Escape Spacesuit. This unique opportunity provides students a broader perspective of how their work fits in to the overall NASA Vision for Exploration. 13 William Paloski, Ph.D.; Charles Layne, Ph.D.; & Mark Clarke, Ph.D., Department of Human Health & Performance, University of Houston Masters Program in HLS Elective graduate education in space life sciences. The University of Houston, Department of Human Health & Performance station will focus on a) their new MS in Human Space Exploration Sciences, and b) their joint work with the JSC labs on a Space Life Sciences PhD option within the existing programs, and c) the distance learning and immersive environment techniques that they have been developing for the past few years. They will present a poster, handouts, and computer-supported content demonstrations. They will also discuss the potential utility of these items for use in K-16 STEM classes. Jennifer Beccera, HRPEO Bilingual Educator; Nubia Carvajal, HRPEO Bilingual Educator; Jaqueline M. Cortez, HRPEO Primary Education Lead NASA HRPEO Primary School Programs Fit Explorer - Living Bones, Strong Bones – Maintaining healthy bones is as important to astronauts during their space mission as it is to all on Earth. In this activity, participants will have the opportunity to conduct an experiment that illustrates the importance of healthy bones. 21st Century Explorer - Cleaning Water - The astronauts onboard the International Space Station (ISS) join those of us on Earth in the recycling effort. They recycle their water, including the moisture they exhale, sweat, and the water they use to shower and shave. These wastewaters are purified and then used as drinking water. In this activity, participants will create and test a water filtering system. Martha Grigsby, HRPEO Secondary Educator; Natalee Lloyd, HRPEO Secondary Educator; Frank Hughes, VP for Training and Education, Tietronix Software; Monica Trevathan, HRPEO Secondary Education Lead HRPEO High School STEM: Real World Applications Feature #1) Use Google Earth to experience the change in velocity and altitude of the Space Shuttle during the ascent phase. Discover Math & Science @ Work (High School Advanced Placement project) and Exploring Space Through Math (High School Mathematics Applications project) and learn how HRPEO uses real NASA applications in Science and Math to inspire and educate students. Feature #2) So, you think you know about the Apollo Program? Test your knowledge of the Apollo Era and discover HRPEO’s special series for High School Advanced Placement courses in US History and Human Geography called “Celebrating Apollo.” William Thomson, Ph.D., NSBRI Education Program Lead; Ron McNeel, DrPH, Project Director for NSBRI’s Graduate and Post-Graduate Programs; Kristen Boucher, NSBRI Summer Internship Coordinator NSBRI Engaging Learners at All Levels in Space-Life Education Through development of curriculum materials, workshops for teachers, web-based educational products, graduate and post-doctoral training in space life sciences and bioastronautics, and summer internship programs, the NSBRI’s education team translates and transfers knowledge from NSBRI science and technology teams to learners across the education continuum. Greg Vogt, Ed.D., Mission Education Lead; Deanne Erdmann, M.S., Managing Editor of BioEd Online Butterflies In Space 2010 In an Internet-based educational project that excited students and teachers around the world, four Painted Lady butterflies completed their life cycle on the International Space Station. Students and teachers across the nation grew similar organisms in their classrooms and designed and conducted their own science investigations in this NSBRI-supported investigation. Approximately 3,000 teachers registered their classes (170,000 students) to participate. A national student science poster competition is underway. 14 Tacey Baker, Space Life Sciences Directorate, Space Life Sciences Academy Integration Facilitator Space Life Sciences Academy and Partnership with Tufts University STOMP Program A new strategic effort exists within the directorate aimed at fostering and developing technical and leadership skills of Space Life Sciences personnel at all NASA centers, and educating NASA and non-NASA personnel in space life sciences and human health and performance disciplines. Initial efforts of the Space Life Sciences Academy include creating a centralized collection of Space Life Sciences training, curriculum and educational opportunities available either within the directorate or through partnering universities. Participation in the Academy is open to internal programs, academic institutions, and industry. The Academy will be populated by civil servants, contractors, university staff, scientists from other centers, and industrial scientists. Curriculum of the Academy will address all areas of space life sciences, selected topics in habitat and environment, career development, and outreach to the community. An outreach effort currently in formulation is with Tufts University to implement their STOMP as a pilot at JSC. STOMP is Student Teacher Outreach Mentorship Program and the goal is to incorporate Space Life Sciences content into the STOMP interactive approach to deliver space exploration themed educational content to elementary students. Traci Knight, HRPEO Outreach Lead; Melissa Saffold, HRP Project Lead, John Frassanito & Associates; Jack Mulvaney, Interface Designer, John Frassanito & Associates HRPEO Outreach Efforts for the Human Research Program & ESMD Communications Expanding the use of social media with animation, video and audio casting, and websites. At the display the team will provide people with an update on what is currently happening with the new External HRP website, the presentation content that has been prepared for the Human Research Program and future plans. 3:15 Lloyd C. Thomson W. Session Summary and Closure 15 Thursday, February 4, 2010 EXPLORATION MEDICAL CAPABILITY I 1:00 p.m. – 3:15 p.m. Westchester Room Chairs: David Baumann Babs Soller, Ph.D. 1:00 Crum L. A.* Bailey M. R. Carter S. J. Shah A. Sapozhnikov O. A. Teichman J. Smart Therapeutic Ultrasound for Mission-Critical Medical Care [Abstract #1043] 1:15 Soller B. R.* Ellerby G. Zou F. Scott P. Jin C. Lee S. M. C. Coates J. Biosensors for EVA: Improved Instrumentation for Ground-Based Studies [Abstract #1048] 1:30 Atchison D.* Fung P. Whalen R. Bergner D. Biomedical Sensors for EVA and IVA [Abstract #1030] 1:45 Tai Y-C.* Ho C-M. In-Flight Blood Analysis Technology for Astronaut Health Monitoring [Abstract #1018] 2:00 Bae C. Bishara A. Yin Z. Chan E. Y.* Universal In-Flight Health Diagnostic Technology: rHEALTH Sensor and Nanostrips [Abstract #1118] 2:15 Krihak M.* Fung P. Whalen R. Bergner D. Lander/Outpost Inflight Lab Analysis – ARC [Abstract #1019] 2:30 Qin Y-X.* Cheng J. Ferreri S. Xia Y. Serra-Hsu F. Lin W. Rubin C. Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing [Abstract #1046] 2:45 Dulchavsky S. A.* Amponsah D. Knuth T. Sargsyan A. E. Hamilton D. R. Ebert D. Ultrasound Fracture Diagnosis in Space [Abstract #1014] 3:00 Discussion 16 Matsumoto Y. Thursday, February 4, 2010 HUMAN HEALTH AND COUNTERMEASURES INTEGRATED PLENARY 1:00 p.m. – 2:00 p.m. Galleria Ballroom I and II Chairs: Jan Meck, Ph.D. Lauren Merkle, Ph.D. 1:00 Meck J.V.* Session Introduction 1:05 Bloomberg J. J.* Arzeno N. Buxton R. E. Feiveson A. H. Kofman I. Lawrence E. L. Lee S. M. C. Mulavara A. P. Peters B. T. Platts S. H. Ploutz-Snyder L. L. Reschke M. F. Ryder J. Spiering B. A. Stenger M. B. Wood S. J. Defining the Physiological Factors That Contribute to Postflight Changes in Functional Performance [Abstract #1054] 1:20 Ploutz-Snyder L. L.* Integrated Resistance and Aerobic Training Study (iRATS) [Abstract #1108] 1:30 Macias B. R. Swift J. M. Lima F. Greene E. S. Allen M. R. Bloomfield S. A.* Weight Bearing in Simulated 1/16th and 1/3rd Gravity Does Not Prevent Cancellous Bone Loss [Abstract #1145] 1:40 Lang T. F.* Streeper T. S. Cavanagh P. R. Saeed I. H. Carpenter R. D. Frassetto L. A. Lee S. M. C. Spiering B. A. Grodsinsky C. M. Funk J. Hanson A. M. Bloomberg J. J. Mulavara A. P. Sibonga J.D. An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions [Abstract #1076] 1:50 Meck J.V.* Closing Comments 17 Thursday, February 4, 2010 IMMUNOLOGY 2:00 p.m. – 3:30 p.m. Tanglewood Room Chair: Brian Crucian, Ph.D. 2:00 Crucian B.* Introduction 2:10 Crucian B.* Chouker A. Stowe R. Mehta S. Salam A. Feuerecker M. Quiriarte H. Pierson D. Sams C.* CHOICE - Directed Study: Consequences of longterm-Confinement and Hypobaric HypOxia on Immunity in the Antarctic Concordia Environment [Abstract #1150] 2:30 Nickerson C. Ott C.M.* Evaluation of Host-pathogen Interactions During Exposure to Microgravity Analogues 2:50 Crucian B.* Mehta S. Stowe R. Uchakin P. Quiriarte H. Pierson D. Sams C. Validation of Procedures for Monitoring Crewmember Immune Functions [Abstract #1151] 3:10 Crucian B.* Closing Comments 18 Thursday, February 4, 2010 MUSCLE 2:00 p.m. – 3:30 p.m. Galleria Ballroom I and II Chairs: Lori Ploutz-Snyder, Ph.D. Jeffrey Ryder, Ph.D. 2:00 English K. Mamerow M. Sheffield-Moore M. Paddon-Jones D.* A Low-Volume Nutritional Countermeasure to Maintain Muscle Mass and Function During Space Exploration [Abstract #1101] 2:15 Adams G. R.* Caiozzo V. J. Baldwin K. M. Tesch P. Owerkowicz T. Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device [Abstract #1117] 2:30 Mulavara A. P.* Fiedler M. Kofman I. Fisher E. Wood S. Serrador J. Peters B. Cohen H. Reschke M. F. Bloomberg J. J. Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long Duration Spaceflight [Abstract #1036] 2:45 Levine B.* Bungo M.W. The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles, and Bones 3:00 Moore A. D.* Evetts S. N. Feiveson A. H. Lee S. M. C. McCleary F. A. Platts S. H. Maximum Oxygen Uptake during and after Long-Duration Space Flight [Abstract #1148] 19 Thursday, February 4, 2010 NUTRITION 2:00 p.m. – 3:30 p.m. Plaza Ballroom Chairs: Scott M. Smith, Ph.D. Sara Zwart, Ph.D. 2:00 Zwart S. R.* Locke J. Pierson D. Mehta S. Bourbeau Y. Parsons H. Smith S. M. Vitamin D: Findings from Antarctic, Bed Rest, Houston, and ISS [Abstract #1056] 2:30 Smith S. M.* Zwart S. R. Heer M. Ericson K. Coburn S. P. Nutritional Status Assessment (SMO 016E) [Abstract #1057] 20 Booth S. L. Jones J. A. Lupton J. Thursday, February 4, 2010 SPACE HUMAN FACTORS AND HABITABILITY I – Space Human Factors Engineering 1:00 – 3:15 p.m. Bellaire Room Chairs: Janis Connolly, M. Arch. Mary Kaiser, Ph.D. Working Group Discussion The community will discuss the proposed revision of the risk and gap structure. 21 Thursday, February 4, 2010 SPACE RADIATION I -- CANCER 1:00 p.m. – 3:15 p.m. Post Oak Room Chairs: Jerry Shay, Ph.D. Honglu Wu, Ph.D. 1:00 Minna J. D.* Ding L. Park S. Yang C. R. Girard L. Xie Y. Xie X. J. Peyton M. Gao B. Delgado O. Richardson J. Asaithamby A. Larsen J. Sullivan J. Das A. Gazdar A. Burma S. Chen D. Story M. Shay J. W. Molecular and Biologic Responses of Human Bronchial Epithelial Cells and Mouse Models of Lung Cancer to HZE Particle and High and Low Dose g-Radiation [Abstract #1104] 1:25 Costes S. V.* Groesser T. Mukhopadhyay R. Yaswen P. Kronenberg A. Rydberg B. BarcellosHoff M. H. NSCOR Transition: From Mechanisms of HZE Damage and Repair in Human Epithelial Cells to the Contribution of Non-targeted Effects in HZE Cancer Risk [Abstract #1144] 1:50 Bailey S. M.* Telomeres and Double-Strand Breaks - making "ends" meet [Abstract #1082] 2:15 Ianzini F* Napoli E. Kosmacek E. A. Mackey M. A. Role of High-LET Radiation-Induced Mitotic Catastrophe in Mutagenesis: Implication for Carcinogenesis. [Abstract #1033] 2:40 Discussion 22 Thursday, February 4, 2010 BEHAVIORAL HEALTH & PERFORMANCE II -- TEAM, SLEEP 3:45 p.m. – 5:45 p.m. Sage Room Chairs: George Brainard, Ph.D. Camille Shea, Ph.D. 3:45 Shea C. Session Overview 3:50 Brainard G. C.* Klerman E. B. Overview of NSBRI Human Factors and Performance Team Projects [Abstract #1059] 4:20 Brady J. V.* Hursh S. R. Roma P. G. Emurian H. H. Gasior E. D. Brinson Z. S. Hienz R. D. Psychosocial Performance Factors in Simulated Space-Dwelling Groups: Status Report [Abstract #1022] 4:30 Keeton K. E.* The Team Risk in the Behavioral Health & Performance Element: Where We've Been and Where We're Going [Abstract #1075] 4:40 Kanas N.* Saylor S. Harris M. Neylan T. Boyd J. Weiss D. S. Baskin P. Cook C. Marmar C. Effects of High vs. Low Autonomy on Space Crewmember Performance (Autonomy) [Abstract #1042] 4:50 Johnston S.* Dinges D. Barger L. Czeisler C. Leveton L. Mollicone D. Baskin P. Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects: Results of the Pilot Study 5:10 Locke J.* Leveton L. Keeton K. Whitmire A. Patterson H. Faulk J. Survey of On-Orbit Sleep Quality: Short Duration Flyers 5:20 Barger L. K.* Brainard G. C. Evans E. E. Fiedler E. Gilliland K. Sipes W. Sullivan J. P. Vincent A. Lockley S. W. Sleep, Circadian Rhythms and Performance of Ground Controllers During the Phoenix Mars Lander Mission [Abstract #1086] 5:30 Discussion 23 Thursday, February 4, 2010 BONE 3:45 p.m. – 5:45 p.m. Galleria I and II Ballroom Chairs: Thomas Lang, Ph.D. Jean Sibonga, Ph.D. 3:45 Amin S. Achenbach S. J. Atkinson E. J. Spector E. Hartnett H. Sibonga J.* Epidemiologic Analyses of Bone Loss in Microgravity [Abstract #1074] 3:55 Gupta S.* Vijayaraghavan S. Uzer G. Tuthill A. Judex S. Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure [Abstract #1113] 4:05 Shirazi-Fard Y. Kupke J. S. Lucas M. W. Greene E. S. Swift J. M. Bloomfield S. A. Hogan H. A.* Comparison of Hindlimb Unloaded Rat Bone Loss and Recovery with ISS Crew Members [Abstract #1114] 4:15 LeBlanc A.* Matsumoto T. Jones J. Shapiro J. Lang T. Smith S. M. Shackelford L. Sibonga J. Evans H. Spector E. Nakamura T. Kohri K. Ohshima H. Bisphosphonate as a Countermeasure to Space Flight-Induced Bone Loss [Abstract #1094] 4:25 Smith S. M.* Zwart S. R. Shackelford L. Heer M. Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism during Spaceflight and Recovery (Pro K) [Abstract #1091] 4:35 Morgan J. L.* Gordon G. Skulan J. Anbar A. Development of a Fast Throughput Method using MC-ICP-MS to Measure Ca Isotopes as a Marker of Bone Mineral Balance [Abstract #1147] 4:45 Bruno J. G.* Carrillo M. P. Phillips T. Edge A. K. Zuniga M. A. Hanson D. Bohmann J. Handheld FRET-Aptamer Sensor for Bone Markers [Abstract #1028] 4:55 Clarke M.* Monitoring of Bone Loss Markers in Human Sweat: A Non-invasive, Time Efficient Means of Monitoring Bone Resorption Markers Under Micro and Partial Gravity Loading Conditions 5:05 Hanson A. M.* Gilkey K. Perusek G.P. Grodsinsky C.M. Thorndike D. Kutnick G. Weaver A.S. Lang T.F. Rice A.J. Cavanagh P.R. Monitoring Bone Health by Daily Load Stimulus during Lunar Missions [Abstract #1080] 5:15 Discussion 24 Thursday, February 4, 2010 CARDIOVASCULAR 3:45 p.m. – 5:45 p.m. Plaza Ballroom Chair: Steven Platts, Ph.D. 3:45 Platts S.* Science Research Plan Review 3:55 Platts S.* Evaluate Alternative Pressure Garments 4:10 Bungo M.W. Levine B.* Integrated Cardiovascular Flight Study: An Update 4:20 Kucik D.* Effect of High Energy Particle Irradiation on Adhesiveness of Vascular Endothelium and Its Consequences for Atherosclerosis 4:35 Berkowitz D.* Radiation, Endothelial Cell Senescence, Accelerated Aging, and Atherosclerosis 4:50 Platts S.* Integrated Research Plan Revisions/Discussion 25 Thursday, February 4, 2010 EXPLORATION MEDICAL CAPABILITY II 3:45 p.m. – 5:45 p.m. Westchester Room Chairs: David Baumann Sharmila Watkins, M.D. 3:45 Dulchavsky S. A.* Sargsyan A. E. Ebert D. Hamilton D. Garcia K. Ultrasound Catalog for Autonomous Medical Care [Abstract #1015] 4:00 Dulchavsky S. A.* Sargsyan A. E. Hamilton D. R. Ebert D. Garcia K. Bracelet Investigation Grant [Abstract #1016] 4:15 Duncan J. M. Bogomolov V. Alferova I. Dulchavsky S. Ebert D.* Garcia K. Hamilton D. Martin D. Matveev V. Sargsyan A. Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and “Braslet-M” Occlusion Cuffs [Abstract #1071] 4:30 Kerstman E. Minard C. Saile L. Freire de Carvalho M. Myers J. Walton M. Butler D.* Iyengar S. Johnson-Throop K. The Integrated Medical Model – A Risk Assessment and Decision Support Tool for Space Flight Medical Systems [Abstract #1041] 4:45 Myers J. G., Jr.* Lewandowski B. E. Brooker J. E. Gilkey K. M. Griffin D. W. Hursh S. R. Mallis M. M. Caldwell J. L. Miller I. Probabilistic Modeling of Specific Medical Events for the Integrated Medical Model [Abstract #1025] 5:00 McQuillen J. B.* McKay T. L. Brown D. F. Zoldak J. T. Griffin D. W. The IntraVenous Fluid Generation Experiment (IV-Gen) [Abstract #1093] 5:15 Weaver A. S.* McQuillen J. B. Stroh J. R. Zoldak J. T. Griffin D. W. Medical Injection System for EVA Contingency [Abstract #1090] 5:30 Iyengar M.S.* Advanced Integrated Clinical Systems – Guided Medical Procedure System 26 Thursday, February 4, 2010 EXTRAVEHICULAR ACTIVITY 3:45 p.m. – 5:45 p.m. Tanglewood Room Chair: Michael L. Gernhardt, Ph.D. 3:45 Gernhardt M.L.* Exploration Analog and Lunar Surface Systems: Status and Future Directions 4:05 Newman D.* Suit Trauma Countermeasures Garment 4:25 Soller B. R.* Ellerby G. Zou F. Scott P. Jin C. Lee S. M. C. Coates J. Biosensors for EVA: Improved Instrumentation for Ground-Based Studies [Abstract #1048] 4:40 Norcross J.* Chappell S. Testing Methodology Lessons Learned from EVA Suit Tests Using POGO and C-9 Analogs 4:55 Q&A, Discussion of Forward Research Needs 27 Thursday, February 4, 2010 SENSORIMOTOR 3:45 p.m. – 5:45 p.m. Galleria Ballroom III Chairs: Jacob Bloomberg, Ph.D. Charles Oman, Ph.D. 3:45 Wood S. J.* Clarke A H. Rupert A. H. Harm D. L. Clément G. R. ZAG-Otolith: Modification of Otolith-Ocular Reflexes, Motion Perception and Manual Control During Variable Radius Centrifugation Following Space Flight [Abstract #1044] 3:55 Moore S. T.* Dilda V. MacDougall H. G. Assessment of operator proficiency following long-duration spaceflight [Abstract #1098] 4:05 Moore S. T.* Dilda V. Curthoys I. S. MacDougall H. G. Galvanic vestibular stimulation (GVS) as an analog of post-flight sensorimotor dysfunction [Abstract #1097] 4:15 Bloomberg J. J.* Peters B. T. Mulavara A. P. Brady R. Batson C. Cohen H. S. Sensorimotor Adaptability Training Improves Motor and Dual-Task Performance [Abstract #1052] 4:25 Oman C. M. Liu A.M.* Advanced Displays for Efficient Training and Operation of Robotic Systems 4:35 Young L. R.* Duda K. R. Clark T. K. Stimpson A. J. Oman C. M. Sensorimotor Interaction with Vehicle Displays and Controls to Enhance Human-Machine Cooperation During Precision Lunar Landing [Abstract #1136] 4:45 Small R. L. Wilkens C.* Modeling and Mitigating Spatial Disorientation in Low g Environments 4:55 Mulavara A.* Fiedler M. Kofman I. Fisher E. Wood S.J. Serrador J. Peters B. Cohen H. Reschke M. Bloomberg J. Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long Duration Spaceflight [Abstract #1036] 5:05 Stone L.S.* Robust Human-System Interface Design for Spaceflight-Induced Environments 5:15 Li R.* Skopljak B. He S. Yilmaz A. Jiang J. Banks M. Oman C. Reducing Spatial Disorientation Risks in Manned Missions [Abstract #1140] 28 Thursday, February 4, 2010 SPACE HUMAN FACTORS AND HABITABILITY II – ADVANCED FOOD TECHNOLOGY (AFT)/ ADVANCED ENVIRONMENTAL HEALTH (AEH) 3:45 – 5:45 p.m. Bellaire Room Chairs: Michele Perchonok, Ph.D. C. Mark Ott, Ph.D. Working Group Discussions AFT: The community will discuss updates to the Advanced Food Technology Project. AEH: The community will discuss advances in lunar dust research. 29 Thursday, February 4, 2010 SPACE RADIATION II -- CNS, DEGENERATIVE, AND ACUTE RISKS 3:45 p.m. – 5:45 p.m. Post Oak Room Chairs: Ann Kennedy, Ph.D. Janice Huff, Ph.D. 3:45 Cucinotta F. A.* Chappell L. J. Kim M.-H. Y. Space Radiation Heart Disease Risk Estimates for Lunar and Mars Missions [Abstract #1141] 4:10 Nelson G. A. * Chang P. Favre C. Fike J. R. Komarova N. Limoli C. Mao X. W. Obenaus A. Raber J. Spigelman I. Soltesz I. Song S. K. Stampanoni M. Vlkolinsky R. Wodarz D. NSCOR Transition: From Progressive Alterations of CNS Structure & Function are Caused by Charged Particle Radiation to Charged Particle Radiation & Resultant Oxidative Stress Elicit Deleterious Functional Changes in the CNS [Abstract #1111] 4:35 Kennedy A. R.* Weissman D. King G. Miller A. Freund G. Wagner E. McDonough J. Cengel K. Center of Acute Radiation Research: Acute Radiation Biological Effects Resulting from Exposure to Galactic Cosmic Rays and Protons from Solar Particle Events [Abstract #1066] 5:00 Trani D. Datta K. Doiron K. Fornace A. J., Jr.* Space Radiation and Intestinal Tumorigenesis Risk Assessment [Abstract #1047] 5:25 Discussion 30 Thursday, February 4, 2010 POSTER SESSION 6:00 p.m. – 8:00 p.m. Chevy Chase Room 6:00 – 7:00 – I 7:00 – 8:00 -- II Behavioral Health and Performance Posters Ahmad A.* Hale K. Carpenter A. Kokini C. Jones D. CogGauge: A Cognitive Assessment Tool [I - Poster BHP-1, Abstract #1020] Czeisler C. A.* Anderson C. Chang A-M. Cain S. W. Ronda J. M. Duffy J. F. Evaluation of Photic Countermeasures for Circadian Entrainment of Neurobehavioral Performance and SleepWake Regulation Before and During Spaceflight [II - Poster BHP-2, Abstract #1072] Hienz R. D.* Davis C. M. Weed M. R. Roma P. G. Guida P. M. Gooden V. L. Brady J. V. Detecting the Effects of Space Radiation on Neurobehavioral Function [I - Poster BHP-3, Abstract #1021] Dean D. A. II St. Hilaire M. A. Phillips A. J. K. Sriram K. Wang W. Klerman E. B.* Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space [II - Poster BHP-4, Abstract #1053] Lathan C. E.* Clément G. R. Skinner A. D. Mental Representation of Spatial Cues (3D-Space) [I - Poster BHP-5, Abstract #1115] Van Reen E. Lockley S. W.* Characteristics of Light Exposure Necessary for Development of Optimal Countermeasures to Facilitate Circadian Adaptation and Enhance Alertness and Cognitive Performance in Space [II - Poster BHP-6, Abstract #1088] Marquez J. M.* McCurdy M. A Scheduling and Planning Tool in NEEMO 14 – A Simulated Space Environment [I - Poster BHP-7] Mollicone D. J.* Mott C. G. Dinges D. F. Individualized Fatigue Meter for Facilitating Crew Performance in Space [II - Poster BHP-8, Abstract #1109] Oman C. M.* Liu A M. Evans E. Natapoff A. Czeisler C. A. Barger L. K. Lockley S. W. Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations [I - Poster BHP-9, Abstract #1096] Otto C. A.* Long Duration Space Flight Causing Brain Changes Associated with Depression and Post Traumatic Stress Disorder [II - Poster BHP-10, Abstract #1146] Palinkas L. A. Keeton K. E. Shea C.* Leveton L. B. Psychosocial Characteristics of Optimum Performance in Isolated and Confined Environments (ICE) [I - Poster BHP-11, Abstract #1067] Exploration Medical Capability Posters Beck G. Crossin J. Gaynor M.* Moulton S. Myung D. Integration of iRevive with the Lightweight Trauma Module [II - Poster ExMC-1, Abstract #1058] Fitts M. A.* Johnson-Throop K. A. Ph.D Havelka J. Thomas D. Life Sciences Data Archive (LSDA) in the Post-Shuttle Era [I - Poster ExMC-2, Abstract #1087] 31 Mourad P. D.* Kliot M. Illian P. R. Automated Transcranial Doppler in support of NASA's Medical Needs [II - Poster, ExMC-3, Abstract #1017] McMonigal K. A.* Pietrzyk R. A. Sams C. F. Johnson M. A. NASA Biological Specimen Repository [I - Poster ExMC-4, Abstract #1026] Olson S. L.* Medical Oxygen Fire Safety [II - Poster ExMC-5, Abstract #1068] Rood A. T.* Moore J. M. Dashevsky D. Davis S. Ryan E. J. Muller M. Glickman E. L. Sparks K. E. Lunar Health Monitor-A Wearable System to Monitor Astronaut Health Status [I -Poster ExMC-6, Abstract #1062] Human Health and Countermeasures Posters Bateman T. A.* Bandstra E. R. Willey J. S. Judex S. Vazquez M. E. Nelson G. A. 50 cGy of Simulated Galactic Cosmic Rays Degrades both Cortical and Trabecular Bone in Mice [II - Poster HHC-1, Abstract #1124] Macias B. R. Swift J. M. Lima F. Greene E .S. Allen M. R. Bloomfield S. A.* Weight Bearing in Simulated 1/6th and 1/3rd Gravity Does Not Prevent Cancellous Bone Loss [I - Poster HHC-2, Abstract #1145] Cavanagh P. R.* Rice A. J. Novotny S. Hanson A. M. Gopalakrishnan R. Kuklis M. Davis B. L. Genc K. O. Englehaupt R. K. Rizk R. Y. Ilaslan H. Licata A. Exercise as a Countermeasure to Bone Demineralization During 12-Week of Bedrest [II - Poster HHC-3, Abstract #1092] Ellman R.* Sibonga J. D. Bouxsein M. L. Data Mining Activity for Bone Discipline: Calculating a Factor of Risk for Hip Fracture in Long-Duration Astronauts [I - Poster HHC-4, Abstract #1122] Androjna C. McCabe N. P. Midura R. J.* Extent, Causes and Countermeasures of Impaired Fracture Healing in Hypogravity [II - Poster HHC-5, Abstract #1123] Mehta S. K.* Cohrs R. J. Gilden D. H. Tyring S. K. Castro V. A. Ott C. M. Pierson D. L. Latent Virus Reactivation: From Space to Earth [I - Poster HHC-6, Abstract #1125] Johnson A. W.* Hoffman J. A. Newman D. J. Mazarico E. M. Zuber M. T. An Integrated EVA Mission Planner and Support Tool for Future Planetary Exploration [II- Poster HHC-7, Abstract #1084] NSBRI Postdoctoral Fellows’ Posters Kubota T.* Long R. K. Elalieh H. Z. Bikle D. D. Interaction between IGF-1 and Integrin Signaling in the Response of Bone to Mechanical Load [II - Poster NSBRI1, Abstract #1133] Olabisi R. M.* Lazard Z. W. Olmsted-Davis E. A. Davis A. R. West J. L. The Effect of Nacre on Murine Osteoblasts in Culture [I - Poster NSBRI-2, Abstract #1131] 32 Pandorf C. E.* Haddad F. Baldwin K. M. Molecular Mechanisms that Impact Transcription of Myosin Genes in Skeletal Muscle in Response to Unloading [II - Poster NSBRI-3, Abstract #1127] Sa R. C.* Darquenne C. Prisk G. K. Variability in flow distribution within the lung and its effects on deposition and clearance of inhaled particles in normal and reduced gravity [I - Poster NSBRI-4, Abstract #1130] Phillips A. J. K.* Physiologically-based modeling of sleep-wake scheduling and the effects of pharmaceuticals [II - Poster NSBRI-5, Abstract #1137] Songer J. E.* Eatock R. A. Frequency Characteristics of the Mammalian Saccular Epithelium [I - Poster NSBRI-6, Abstract #1135] Souza R. B.* Feeley B. Kadel N. Li X. Link T. Majumdar S. The Influence of Unloading on Knee Cartilage Composition: Initial experiences and preliminary data [II - Poster NSBRI-7, Abstract #1149] Trani D.* Datta K. Tyburski J. Moon B. H. Fornace A. Acute and late intestinal effects induced by exposure to HZE and high-energy protons beyond Low Earth Orbit (LEO): Mouse model approaches [I - Poster NSBRI-8,l Abstract #1138] Willey J.* Radiation Effects on Bone Tissue and Cells in Reduced Gravity [II - Poster NSBRI-9, Abstract #1139] Carleton S.* Therapeutic Strategies in a Mouse Model of Osteogenesis Imperfecta (OI): Targeting the "Muscle-Bone Unit" [I Poster NSBRI-10] 33 Thursday, February 4, 2010 POSTER SESSION 6:00 p.m. – 8:00 p.m. West Alabama Room 6:00 – 7:00 – I 7:00 – 8:00 -- II Space Human Factors and Habitability Posters Chu S. R. Allen C. S.* Spacecraft Internal Acoustic Environment Modeling [I - Poster SHFH-1, Abstract #1070] Barshi I.* Byrne V. Arsintescu L. Connell E. Human Factors in Training – Space Flight Resource Management Training [II - Poster SHFH-2, Abstract #1024] Byrne V.* Barshi I. Arsintescu L. Connell E. Human Factors in Training - Space Medical Proficiency Training [I - Poster SHFH-3, Abstract #1023] Holubec K. V.* Tillman B. W. Connolly J. H. Spaceflight Human System Standards [II - Poster SHFH-4, Abstract #1119] Catauro P. M.* Design of a Nutrition Delivery System for Use in Suited Contingency Survival Operations [I - Poster SHFH-5, Abstract #1078] Adelstein B. D. Beutter B. R. Kaiser M. K.* McCann R. S. Stone L. S. Root P. J. Holden K. L. Combined Whole-Body Vibration Plus G-Loading Influences on Visual Performance and Operator Ratings [II - Poster SHFH-6, Abstract #1112] Holden K. L.* McCann R. S. Thompson S. G. Kaiser M. K. Sandor A. Adelstein B. D. Beutter B. R. Stone L. S. Godfroy M. Information Presentation [I - Poster SHFH-7, Abstract #1063] Begault D. R. Wenzel E. M. Oziomek T. V.* Catauro P. M. Bulk Overwrap Packaging System [II - Poster SHFH-8, Abstract #1079] Thompson S.* Holden K. Ebert D. Root P. Adelstein B. Jones J. Short Duration Bioastronautics Investigation 1904: Human Factors Assessment of Vibration Effects on Visual Performance During Launch [I - Poster SHFH-9, Abstract #1060] Space Radiation Posters Asaithamby A.* Hu B. Chen D. J. Cellular Responses to DNA Damages Induced by High Energy and High-Z Particles Irradiation [II -Poster SR-1, Abstract #1073] de Toledo S. M. Buonanno M. Autsavapromporn N. Li M. Gonon G. Zhang J. Shim G. Azzam E. I.* The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space Radiation [I - Poster SR-2, Abstract #1069] Aypar U. Morgan W. F. Baulch J. E.* Epigenetic Alterations In Clones Exhibiting Radiation Induced Genomic Instability [II-Poster SR-3, Abstract #1120] 34 Bennett P. V.* Abele W. A. Stisova V. Sutherland B. M. Survival and Transformation to Anchorage Independence of Primary Human Neonatal Foreskin Fibroblasts to Low Dose and Low Dose Rate Exposures of Simulated Solar Particle Event Protons [I -Poster SR-4, Abstract #1061] Berkowitz D.* Ionizing Radiation and Its Effects on Cardiovascular Function in the Context of Space Flight [II - Poster SR-5] Chang P. Y. Bjornstad K. A. Rosen C. J. Jalbert L. E. Blakely E. A.* Particle Radiation-Induced Alteration in the Expression of Extracellular Matrix Molecules in Lens [I - Poster SR-6, Abstract #1126] Britten R. A.* Johnson A. J. Davis L. K. Parris B. Lonart G. Green-Mitchell S. Chabriol O. Sanford L. Singletary S. J. Drake R. R. Spatial Memory and Attentional Set Shifting are Significantly Impaired Following Exposure to 20 cGy Hze particles. [II - Poster SR-7, Abstract #1107] Chang P. Y.* Bakke J. Wang A. Impact of sequential proton and iron ions exposure in vivo. [I - Poster SR-8, Abstract #1116] Chen B. P.* DeCarolis N. A. Ahn F. Petrik D. Malhotra S. LeBlanc J. Carlton A. Melvin N. Eisch A. J. Impact of 56Fe Particle Irradiation on Adult Neural Stem Cells In Vivo [II - Poster SR-9, Abstract #1039] Loucas B. D. Eberle R. L. Cornforth M. N.* Structural Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate [I - Poster SR-10, Abstract #1083] Rosi S. Ferguson R. Fishman K. Levy W. Raber J. Obenaus A. Fike J. R.* Trauma Induced Alterations in Cognition and Expression of the Behaviorally-Induced Immediate Early Gene Arc Are Reduced by a Previous Exposure to 56Fe [II - Poster SR-11, Abstract #1037] Hada M.* Cucinotta F. A. Wu H. Distribution of chromosome breakpoints in human epithelial cells exposed to low- and high-LET radiation [I - Poster SR-12, Abstract #1106] Kronenberg A.* Dan C. Sandfort K. Turker M. Evidence for genomic instability in normal mouse epithelium exposed to charged particle radiation in situ [II - Poster SR-13, Abstract #1132] Lumpkins S. B.* Yang H. Magpayo N. Held K. D. Space Radiation-Induced Bystander Signaling between Mixed Cultures of Human Fibroblasts and Keratinocytes and Development of 3D Model [I - Poster SR-14, Abstract #1045] Rabin B. M.* Joseph J. A. Shukitt-Hale B. Carrihill-Knoll K. Age as a Factor Influencing Cognitive Impairment Following Exposure to HZE Particles [II - Poster SR-15, Abstract #1031] Rithidech K.* Reungpatthanaphong P. Honikel L. Golightly M. Anderson C. W. Dose-rate Effects of Protons on the Induction of Genomic Instability In Vivo [I - Poster SR-16, Abstract #1051] Yamamoto M. L.* Reliene R. Hacke K. Hafer K. Westbrook A. Bral M. Kelly O. Trouiller B. Schiestl R. H. Effects of Space Radiation on Genetic Instability, Neuromotor Function, Carcinogenesis and Longevity in Ataxia Telangiectasia Deficient Mice [II - Poster SR-17, Abstract #1077] 35 Eskiocak U. Kim S. B. Roig A. I. Kitten E. Batten K. Conelius C. ZouY. S. Wright W. E. Shay J. W.* CDDO-Me Protects Against Heavy Ion-Induced Transformation of Human Colonic Epithelial Cells [I - Poster SR-18, Abstract #1103] Templin T. Paul S. Amundosn S. Smilenov L.* miRNA profiling of radiation response: A systems biology approach to understanding regulation of proton and heavy ion dose effects [II - Poster SR-19, Abstract #1095] Tseng B. P.* Tran K. Lan M. L. Acharya M. M. Cho-Lim J. Limoli C. L. Low dose and dose rate effects of proton irradiation on stem and precursor cells [I - Poster SR-20, Abstract #1038] Zafar F. Seidler S. B. Kronenberg A. Schild D. Wiese C.* Homologous Recombination Contributes to the Repair of DNA Double-Strand Breaks Induced by High-Energy Iron Ions [II - Poster SR-21, Abstract #1105] 36 FRIDAY PLENARY SESSION Friday, February 5, 2010 NEW TALENT SHOWCASE 8:00 a.m. – Noon Galleria Ballroom I and II 8:00 Kozlowski S. W. J.* DeShon R. P. Schmitt N. Biswas S. Hough L. Locke J. P. Developing, Maintaining, and Restoring Team Cohesion [Abstract #1102] 8:15 Salas E.* Smith-Jentsch K. A. Fiore S. Optimizing Crew Performance in Long Duration Space Exploration: Best Practices for Team Training and Cohesion Measurement [Abstract #1040] 8:30 Duda K. R.* Hainley C. J. Jr. Wen H. Y. Oman C. M. Human-Automation Interactions and Performance Analysis of Lunar Lander Supervisory Control [Abstract #1049] 8:45 Cooper M. R.* Effect of Processing and Subsequent Storage on Nutrition [Abstract #1055] 9:00 Wallace W. T.* Taylor L. A. Jeevarajan A. S. Understanding the Reactivity of Lunar Dust for Future Lunar Missions [Abstract #1050] 9:15 Dziegielewski J.* Valerie N. C. K. Hosing A. S. Casarez E. V. Jr. Parsons S. J. Larner J. M. Effects of Prolonged Exposure to Space Radiation on Carcinogenesis and Neuroendocrine Differentiation in Human Prostate Cells [Abstract #1029] 9:30 Westby C. M.* Phillips T. R. Stenger M. B. Platts S. H. Vascular Differences Between Men and Women at 6 degree Head Down Bed Rest [Abstract #1089] 10:00 Break (Galleria Foyer) 10:30 Adrian D. LeBlanc, Ph.D. USRA Young Investigator Award 10:40 David A. Watson, Ph.D. Student Poster Recognition 10:50 Ritter J. A.* LeVan M. D. Edwards P. Knox J. C. Development of Pressure Swing Adsorption Technology for Spaceflight Oxygen Concentrators [Abstract #1099] 11:05 McKay T. M. Weaver A. S.* Nelson E. S. Reusable Point-of-Care Diagnostic Technology Development [Abstract #1027] 11:20 Dennis Grounds, John B. Charles, Ph.D. Closing Remarks 12:00 Adjourn (Boxed lunches to go – Galleria Foyer) 37 Author Index Abele W. A. 35 Acharya M. M. 36 Achenbach S. J. 24 Adams G. R. 19 Adelstein B. D. 34, 34 Ahmad A. 31 Ahn F. 35 Alferova I. 26 Allen C. S. 34 Allen M. R. 17, 32 Amin S. 24 Amponsah D. 16 Amundson S. 36 Anbar A. 24 Anderson C. 31 Anderson C. W. 35 Androjna C. 32 Arsintescu L. 34 Arzeno N. 17 Asaithamby A. 22, 34 Atchison D. 16 Atkinson E. J. 24 Autsavapromporn N. 34 Aypar U. 34 Azzam E. I. 34 Bae C. 16 Bailey M. R. 16 Bailey S. M. 22 Bakke J. 35 Baldwin K. M. 19, 33 Bandstra E. R. 32 Banks M. 28 Banks S. 12 Barcellos-Hoff M. H. 22 Barger L. K. 23, 31 Barshi I. 34 Baskin P. 23 Basner M. 12 Bateman T. A. 32 Batson C. 28 Batten K. 36 Baulch J. E. 34 Beck G. 31 Begault D. R. 34 Bennett P. V. 35 Bergner D. 16 Berkowitz D. 25, 35 Beutter B. R. 34 Bikle D. D. 32 Bishara A. 16 Biswas S. 37 Bjornstad K. A. 35 Blakely E. A. 35 Bloomberg J. J. 17, 19, 28 Bloomfield S. A. 17, 24, 32 Bogomolov V. 26 Bohmann J. 24 Booth S. L. 20 Bourbeau Y. 20 Bouxsein M. L. 32 Boyd J. 23 Brady J. V. 23, 31 Brady R. 28 Brainard G. C. 23 Bral M. 35 Brinson Z. S. 23 Britten R. A. 35 Brooker J. E. 26 Brown D. F. 26 Bruno J. G. 24 Buckey J. C. Jr. 12 Bungo M. W. 19, 25 Buonanno M. 34 Burma S. 22 Butler D. 26 Buxton R. E. 17 Byrne V. 34 Cain S. W. 31 Caiozzo V. J. 19 Caldwell J. L. 26 Carlton A. 35 Carleton S. 33 Carpenter A. 31 Carpenter R. D. 17 Carrihill-Knoll K. 35 Carrillo M. P. 24 Carter S. J. 16 Cartreine J. A. 12 Casarez E. V. Jr. 37 Castro S. 8 Castro V. A. 32 Catauro P. M. 34 Cavanagh P. R. 17, 24, 32 Cengel K. 30 Chabriol O. 35 Chan E. Y. 16 Chang A-M. 31 Chang P. Y. 30, 35 Chappell L. J. 30 Chappell S. 27 Chen B. P. 35 Chen D. J. 22, 34 Cheng J. 16 Cho-Lim J. 36 Chouker A. 18 Chu S. R. 34 Clark T. K. 28 Clarke A H. 28 Clarke M. 24 Clément G. R. 28, 31 Coates J. 16, 27 Coburn S. P. 20 Cohen H. S. 28 Cohrs R. J. 32 Conelius C. 36 Connell E. 34 Connolly J. H. 34 38 Cook C. 23 Cooper M. R. 37 Cornforth M. N. 35 Costes S. V. 22 Craske M. G. 12 Crossin J. 31 Crucian B. 18 Crum L. A. 16 Cucinotta F. A. 30, 35 Curthoys I. S. 28 Czeisler C. A. 31 Dan C. 35 Darquenne C. 33 Das A. 22 Dashevsky D. 32 Datta K. 30, 33 Davis A. R. 32 Davis B. L. 32 Davis C. M. 31 Davis L. K. 35 Davis S. 32 de Toledo S. M. 34 Dean D. A. II 31 DeCarolis N. A. 35 Delgado O. 22 DeShon R. P. 37 Dilda V. 28 Ding L. 22 Dinges D. F. 12, 31 Doiron K. 30 Drake R. R. 35 Duda K. R. 28, 37 Duffy J. F. 31 Dulchavsky S. A. 16, 26 Duncan J. M. 26 Dziegielewski J. 37 Eatock R. A. 33 Eberle R. L. 35 Ebert D. 16, 26, 34 Ecker A. 12 Edge A. K. 24 Edwards P. 37 Eisch A. J. 35 Elalieh H. Z. 32 Ellerby G. 16, 27 Ellman R. 32 Emurian H. H. 23 Englehaupt R. K. 32 English K. 19 Ericson K. 20 Eskiocak U. 36 Evans E. E. 23, 31 Evans H. 24 Evetts S. N. 19 Faulk J. 23 Favre C. 30 Feeley B. 33 Feiveson A. H. 17, 19 Ferguson R. 35 Ferreri S. 16 Feuerecker M. 18 Fiedler E. 23 Fiedler M. 19, 28 Fike J. R. 30, 35 Fiore S. 37 Fisher E. 19, 28 Fishman K. 35 Fitts M. A. 31 Fornace A. J. Jr. 30, 33 Frassetto L. A. 17 Freire de Carvalho M. 26 Freund G. 30 Fung P. 16 Funk J. 17 Held K. D. 35 Hienz R. D. 23, 31 Ho C-M. 16 Hoffman J. A. 32 Hogan H. A. 24 Holden K. L. 34 Holubec K. V. 34 Honikel L. 35 Hosing A. S. 37 Hough L. 37 Hu B. 34 Hursh S. R. 23, 26 Gao B. 22 Garcia K. 26 Garcia K. 26 Gasior E. D. 23 Gaynor M. 31 Gazdar A. 22 Genc K. O. 32 Gernhardt M. L. 27 Gilden D. H. 32 Gilkey K. M. 24, 26 Gilliland K. 23 Girard L. 22 Glickman E. L. 32 Godfroy M. 34 Goel N. 12 Golightly M. 35 Gonon G. 34 Gooden V. L. 31 Gopalakrishnan R. 32 Gordon G. 24 Greene E. S. 17, 24, 32 Green-Mitchell S. 35 Griffin D. W. 26 Grodsinsky C. M. 17, 24 Groesser T. 22 Guida P. M. 31 Gupta S. 24 Jalbert L. E. 35 Jeevarajan A. S. 37 Jiang J. 28 Jin C. 16, 27 Johnson A. J. 35 Johnson A. W. 32 Johnson M. A. 32 Johnson-Throop K. A. 26, 31 Johnston S. 23 Jones J. A. 20, 24, 34 Joseph J. A. 35 Judex S. 24, 32 Hacke K. 35 Hada M. 35 Haddad F. 33 Hafer K. 35 Hainley C. J. Jr. 37 Hale K. 31 Hamilton D. 16, 26 Hanson A. M. 17, 24, 32 Hanson D. 24 Harm D. L. 28 Harris M. 23 Hartnett H. 24 Havelka J. 31 He S. 28 Heer M. 20, 24 Hegel M. T. 12 Ianzini F. 22 Ilaslan H. 32 Illian P. R. 32 Iyengar S. 26 Kadel N. 33 Kaiser M. K. 34 Kanas N. 23 Kasdan H. L. 16 Keeton K. E. 23, 31 Kelly O. 35 Kennedy A. R. 30 Kerstman E. 26 Kim M.-H. Y. 30 Kim S. B. 36 King G. 30 Kitten E. 36 Klerman E. B. 23, 31 Kliot M. 32 Knox J. C. 37 Knuth T. 16 Kofman I. 17, 19, 28 Kohri K. 24 Kokini C. 31 Komarova N. 30 Kosmacek E. A. 22 Kozlowski S. W. J. 37 Krihak M. 16 Kronenberg A. 22, 35-36 Kubota T. 32 Kucik D. 25 Kuklis M. 32 Kupke J. S. 24 Kutnick G. 24 Lan M. L. 36 39 Lang T. F. 17, 24 Larner J. M. 37 Larsen J. 22 Lathan C. E. 31 Lawrence E. L. 17 Lazard Z. W. 32 LeBlanc A. 24 LeBlanc J. 35 Lee S. M. C. 16, 17, 19, 27 LeVan M. D. 37 Leveton L. B. 12, 23, 31 Levine B. 19, 25 Levy W. 35 Lewandowski B. E. 26 Li M. 34 Li R. 28 Li X. 33 Licata A. 32 Lima F. 17, 32 Limoli C. L. 30, 36 Lin W. 16 Link T. 33 Liu A M. 28, 31 Lloyd C. 13 Locke J. P. 20, 23, 37 Locke S. E. 12 Lockley S. W. 23, 31 Lonart G. 35 Long R. K. 32 Loucas B. D. 35 Lucas M. W. 24 Lumpkins S. B. 35 Lupton J. 20 MacDougall H. G. 28 Macias B. R. 8, 17, 32 Mackey M. A. 22 Magpayo N. 35 Majumdar S. 33 Malhotra S. 35 Mallis M. M. 26 Mamerow M. 19 Mao X. W. 30 Marmar C. 23 Marquez J. M. 31 Martin D. 26 Matsumoto T. 24 Matsumoto Y. 16 Matveev V. 26 Mazarico E. M. 32 McCabe N. P. 32 McCann R. S. 34 McCleary F. A. 19 McCurdy M. 31 McDonough J. 30 McKay T. L. 26 McKay T. M. 37 McMonigal K. A. 32 McQuillen J. B. 26 Mehta S. K. 18, 20, 32 Melvin N. 35 Metaxas D. 12 Midura R. J. 32 Miller A. 30 Miller I. 26 Minard C. 26 Minna J. D. 22 Mollicone D. J. 23, 31 Moon B. H. 33 Moore A. D. 19 Moore J. M. 32 Moore S. T. 28 Morgan J. L. 24 Morgan W. F. 34 Mott C. G. 31 Moulton S. 31 Mourad P. D. 32 Mukhopadhyay R. 22 Mulavara A. P. 17, 19, 28 Muller M. 32 Myers J. 26 Myers J. G. Jr, 26 Myung D. 31 Nakamura T. 24 Napoli E. 22 Natapoff A. 31 Nelson E. S. 37 Nelson G. A. 30, 32 Newman D. J. 27, 32 Neylan T. 23 Nickerson C. 18 Norcross J. 27 Novotny S. 32 Obenaus A. 30, 35 Ohshima H. 24 Olabisi R. M. 32 Olmsted-Davis E. A. 32 Olson S. L. 32 Oman C. M. 28, 31, 37 Ott C. M. 18, 32 Otto C. A. 31 Owerkowicz T. 19 Oziomek T. V. 34 Paddon-Jones D. 19 Palinkas L. A. 31 Pandorf C. E. 33 Park S. 22 Parris B. 35 Parsons H. 20 Parsons S. J. 37 Patterson H. 23 Paul S. 36 Perusek G. P. 24 Peters B. 19 Peters B. T. 17, 28 Petrik D. 35 Peyton M. 22 Phillips A. J. K. 31, 33 Phillips T. R. 24, 37 Pierson D. L. 18, 20, 32 Pietrzyk R. A. 32 Platts S. H. 17, 19, 25, 37 Ploutz-Snyder L. L. 17 Prisk G. K. 33 Purgason A. 8 Qin Y-X. 16 Quiriarte H. 18 Raber J. 30, 35 Rabin B. M. 35 Reliene R. 35 Reschke M. F. 17, 19, 28 Reungpatthanaphong P. 35 Rice A. J. 24, 32 Richardson J. 22 Rithidech K. 35 Ritter J. A. 37 Rizk R. Y. 32 Roig A. I. 36 Roma P. G. 23, 31 Ronda J. M. 31 Rood A. T. 32 Root P. J. 34 Rose R. D. 12 Rosen C. J. 35 Rosi S. 35 Rubin C. 16 Rubino C. 8 Rupert A. H. 28 Ryan E. J. 32 Rydberg B. 22 Ryder J. 17 Sa R. C. 33 Saeed I. H. MD 17 Saile L. 26 Salam A. 18 Salas E. 37 Sams C. 18, 32 Sandfort K. 35 Sandor A. 34 Sanford L. 35 Sapozhnikov O. A. 16 Sargsyan A. E. 16, 26 Saylor S. 23 Schiestl R. H. 35 Schild D. 36 Schmitt N. 37 Scott P. 16, 27 Seidler S. B. 36 Serrador J. 19, 28 Serra-Hsu F. 16 Shackelford L. 24 Shah A. 16 Shapiro J. 24 Shay J. W. 22, 36 Shea C. 23, 31 Sheffield-Moore M. 19 Shim G. 34 Shirazi-Fard Y. 24 Shukitt-Hale B. 35 Sibonga J. D. 17, 24, 32 40 Singletary S. J. 35 Sipes W. 23 Skinner A. D. 31 Skopljak B. 28 Skulan J. 24 Small R. L. 28 Smilenov L. 36 Smith S. M. 20, 24 Smith-Jentsch K. A. 37 Soller B. R. 16 Soltesz I. 30 Song S. K. 30 Songer J. E. 33 Souza R. B. 33 Sparks K. E. 32 Spatz J. 8 Spector E. 24 Spiering B. A. 17 Spiering B. A. 17 Spigelman I. 30 Sriram K. 31 St. Hilaire M. A. 31 Stampanoni M. 30 Stenger M. B. 17, 37 Stimpson A. J. 28 Stisova V. 35 Stone L. S. 28, 34 Story M. 22 Stowe R. 18 Strangman G. E. 12 Streeper T. S. 17 Stroh J. R. 26 Stuster J. 12 Sullivan J. 22 Sullivan J. P. 23 Supelana C. S. 12 Sutherland B. M. 35 Swift J. M. 8, 17, 24, 32 Tai Y-C. 16 Taylor L. A. 37 Teichman J. 16 Templin T. 36 Tesch P. 19 Theriot C. 8 Thomas D. 31 Thompson S. G. 34 Thomson W. 13 Thorndike D. 24 Tillman B. W. 34 Tran K. 36 Trani D. 30, 33 Trouiller B. 35 Tseng B. P. 36 Turker M. 35 Tuthill A. 24 Tyburski J. 33 Tyring S. K. 32 Uchakin P. 18 Uzer G. 24 Valerie N. C. K. 37 Van Reen E. 31 Vazquez M. E. 32 Vijayaraghavan S. 24 Vincent A. 23 Vlkolinsky R. 30 Wagner E. 30 Wallace W. T. 37 Walton M. 26 Wang A. 35 Wang W. 31 Weaver A. S. 24, 26, 37 Weaver S. 8 Weed M. R. 31 Weiss D. S. 23 Weissman D. 30 Wen H. Y. 37 Wenzel E. M. 34 West J. L. 32 Westbrook A. 35 Westby C. M. 37 Whalen R. 16 Whitmire A. 23 Wiese C. 36 Wilkens C. 28 Willey J. 33 Willey J. S. 32 Wodarz D. 30 Wood S. J. 17, 19, 28 Wright W. E. 36 Wu H. 35 Xia Y. 16 Xie X. J. 22 Xie Y. 22 Yamamoto M. L. 35 Yang C. R. 22 Yang H. 35 Yaswen P. 22 Yilmaz A. 28 Yin Z. 16 Young L. R. 28 Zafar F. 36 Zeffiro T. A. 12 Zhang J. 34 Zhang Q. 12 Zoldak J. T. 26 Zou F. 16, 27 Zou Y. S. 36 Zuniga M. A. 24 Zuber M. T. 32 Zwart S. R. 20, 24 41 NOTES 42 NOTES 43 NOTES 44
