Publications (excluding abstracts)
Original Research Articles
1. DeJersey, J. D., Lahue, R. S., and Martin, R. B. Arch. Biochem. Biophys. 205 536-542 (1980).
Terbium luminescence as a probe of the calcium binding site of trypsin and α-chymostrypsin.
2. Lahue, R. S., and Schachman, H. K. J. Biol. Chem. 259 13906-13913 (1984).
The influence of quaternary structure on the active site of an oligomeric enzyme, catalytic
subunit of aspartate transcarbamoylase.
3. Lahue, R. S., and Schachman, H. K. J. Biol. Chem. 261 3079-3084 (1986).
Communication between polypeptide chains in aspartate transcarbamoylase: conformational
changes at the active sites of unliganded chains resulting from ligand binding to other chains.
4. Lahue, R. S., Su, S-s., and Modrich, P. Proc. Natl. Acad. Sci. 84 1482-1486 (1987).
Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction.
5. Lahue, R. S., Su, S-s., Welsh, K. W., and Modrich, P. UCLA Symp. Mol. Cell. Biol. 125-134
(1987). Analysis of methyl-directed mismatch repair in vitro.
6. Su, S-S., Lahue, R. S., Au, K. G., and Modrich, P. J. Biol. Chem. 263 6829-6835 (1988).
Mispair specificity of methyl-directed mismatch correction in vitro.
7. Lahue, R. S., Au, K. G., and Modrich, P. Science (Research Article) 245 160-164 (1989).
DNA mismatch correction in a defined system.
8. Miret, J. J., Milla, M., and Lahue, R. S. J. Biol. Chem. 268 3507-3513 (1993).
Characterization of a DNA mismatch binding activity from yeast.
9. Cooper, D. L., Lahue, R. S., and Modrich, P. J. Biol. Chem. 268 11823-11829 (1993). Methyldirected mismatch repair is bidirectional.
10. Selva, E. M., New, L., Crouse, G. F., and Lahue, R. S. Genetics 139 1175-1188 (1995)
Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces
cerevisiae.
11. Miret, J. J., Parker, B. O. and Lahue, R. S. Nucleic Acids Research 24 721-729 (1996).
Recognition of DNA insertion/deletion mismatches by an activity in S. cerevisiae.
12. Alani, E., Sokolsky, T., Studamire, B., Miret, J. J. and Lahue, R S. Mol. Cell. Biol.
17 2436-2447 (1997). Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP
hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.
13. Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S. Mol. Cell. Biol. 17 3382-3387 (1997).
Instability of CAG and CTG trinucleotide repeats in Saccharomyces cerevisiae.
14. Selva, E. M., Maderazo, A. B., and Lahue, R. S. Mol. Gen. Genet. 257 71-82 (1997)
Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous
recombination in Saccharomyces cerevisiae.
15. Miret, J. J., Pessoa-Brandao, L., and Lahue, R. S. Proc. Natl. Acad. Sci. 95 12438-12443
(1998). Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide
repeats in Saccharomyces cerevisiae.
16. Corrette-Bennett, S. E., Parker, B. O., Mohlman, N. L., and Lahue, R. S. J. Biol. Chem. 274
17605-17611 (1999). Correction of large mispaired DNA loops by extracts of
Saccharomyces cerevisiae.
17. Spiro, C., Pelletier, R., Rolfsmeier, M. L., Dixon, M. J., Lahue, R. S., Gupta, G., Park, M. S.,
Chen, X., Mariappan, S. V. S., and McMurray, C. T. Mol. Cell 4 1079-1085 (1999).
Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats.
18. Rolfsmeier, M. L., and Lahue, R. S. Mol. Cell. Biol. 20 173-180 (2000). Stabilizing effects of
interruptions on trinucleotide repeat expansions in Saccharomyces cerevisiae.
19. Rolfsmeier, M. L., Dixon, M. J., and Lahue, R. S. Mol. Cell 6 1501-1507 (2000). Mismatch
repair blocks expansions of interrupted trinucleotide repeats in yeast.
20. Rolfsmeier, M. L., Dixon, M. J., Pessoa-Brandao, L., Pelletier, R., Miret, J. J. and Lahue, R. S.
Genetics 157 1569-1579 (2001). Cis-elements regulating trinucleotide repeat instability in
Saccharomyces cerevisiae.
21. Corrette-Bennett, S. E., Mohlman, N. L., Rosado, Z., Miret, J. J., Hess, P. M., Parker, B. O., and
Lahue, R. S. Nucleic Acids Research 29:4134-4143 (2001). Efficient repair of large DNA
loops in Saccharomyces cerevisiae.
22. Dixon, M. J. and Lahue, R. S. DNA Repair 1:765-773 (2002). Examining the potential role of
DNA polymerases η and ζ in triplet repeat instability in yeast.
23. Bhattacharyya, S., Rolfsmeier, M. L., Dixon, M. J., Wagoner, K. and Lahue, R. S. Genetics.
162:579-589 (2002). Identification of RTG2 as a modifier gene for CTG•CAG repeat
instability in Saccharomyces cerevisiae.
24. Pelletier, R., Krasilnikova, M. M., Samadashwily, G. M., Lahue, R., and Mirkin, S. M. Mol.
Cell. Biol. 23 1349-1357 (2003). Replication and expansion of trinucleotide repeats in
yeast.
25. Dixon, M. J. and Lahue, R. S. Nucleic Acids Res. 32:1289-1297 (2004). DNA elements
important for CAG•CTG repeat thresholds in Saccharomyces cerevisiae.
26. Bhattacharyya, S. and Lahue, R. S. Mol. Cell. Biol. 24 7324-7330 (2004). Yeast Srs2 DNA
helicase selectively blocks expansions of trinucleotide repeats.
27. Corrette-Bennett, S. E., Borgeson, C., Sommer, D., Burgers, P. M. J., and Lahue, R. S. Nucleic
Acids Res. 32:6268-6275 (2004). DNA Polymerase δ, RFC, and PCNA are required for
repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.
28. Bhattacharyya, S. and Lahue, R. S. J. Biol. Chem. 280 33311-33317 (2005).
Srs2 helicase of Saccharomyces cerevisiae selectively unwinds triplet repeat DNA.
29. Pelletier, R., Farrell, B. T., Miret, J. J., and Lahue, R. S. Nucleic Acids Res. 33 5667-5676
(2005). Mechanistic features of CAG•CTG repeat contractions in cultured cells revealed by a
novel genetic assay.
30. Farrell, B.T. and Lahue, R.S. Nucleic Acids Res. 34 4495-4505 (2006).
CAG•CTG repeat instability in cultured human astrocytes
31. Collins, N.S, Bhattacharyya, S. and Lahue, R. S. DNA Repair 6 38-44 (2007).
Rev1 enhances CAG•CTG repeat stability in Saccharomyces cerevisiae
32. Daee, D.L., Mertz, T. and Lahue, R. S. Molecular and Cellular Biology 27 102-110
(2007). Post-replication repair inhibits CAG•CTG repeat expansions in
Saccharomyces cerevisiae
33. Claassen, D. A. and Lahue, R. S. Human Molecular Genetics 16 3088-3096 (2007).
Expansions of CAG·CTG repeats in immortalized human astrocytes
34. Razidlo, D. F. and Lahue, R. S. DNA Repair 7 633-640 (2008).
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
35. Dhar, A. and Lahue, R. S. Nucleic Acids Research 36 3366-3373 (2008).
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces
cerevisiae
36. Sommer, D., Stith, C. M., Burgers, P. M. J. and Lahue, R. S. Nucleic Acids
Res. 36 4699-4707 (2008). Partial reconstitution of DNA large loop repair
with purified proteins from Saccharomyces cerevisiae
37. Erlich, R. L., Fry, R. C., Begley, T. J., Daee, D. L., Lahue, R. S., and Samson, L. D. PLoS
ONE 3 e3717 (2008). Anc1, a protein associated with multiple transcription
complexes, is involved in postreplication repair pathway in S. cerevisiae.
38. Gellon, L., Razidlo, D. F., Gleeson, O., Verra, L., Schulz, D, Lahue, R. S., and Freudenreich,
C. H. PLoS Genetics 7(2): e1001298. doi:10.1371/journal.pgen.1001298 (2011).
New functions of Ctf18-RFC in preserving genome stability outside its role in sister
chromatid cohesion.
39. Debacker, K., Frizzell, A., Gleeson, O., Kirkham-McCarthy, L., Mertz, T., and Lahue, R.S.
PLoS Biology 10(2): e1001257. doi:10.1371/journal.pbio.1001257 (2012). Histone
deacetylase complexes promote trinucleotide repeat expansions.
Associated commentary: Choi, C.Q. PLoS Biology 10(2): e1001270.
doi:10.1371/journal.pbio.1001270 (2012). Enzyme inhibitor may offer dual protection
against brain disease
40. Gannon, A-M. M, Frizzell, A., Healy, E., and Lahue, R.S. Nucleic Acids Res. 40 10324-10333
(2012). MutSβ and histone deacetylase complexes promote expansions of trinucleotide
repeats in human cells
41. Stevens, J.R., Lahue, E.E., Li, G-M., and Lahue, R.S. Cell Research 23 565-572 (2013).
Trinucleotide repeat expansions catalyzed by human cell-free extracts
42. Concannon, C. and Lahue, R.S. Nucleic Acids Res. 41 6098-6108 (2013). The 26S proteasome
drives trinucleotide repeat expansions.
43. Concannon, C. and Lahue, R.S. DNA Repair 13 42-49 (2014). Nucleotide excision repair and
the 26S proteasome function together to promote trinucleotide repeat expansions.
44. Frizzell, A., Nguyen, J.H.G., Petalcorin, M.I.R., Turner, K.D., Boulton, S.J., Freudenreich, C.H.
and Lahue, R.S. Cell Reports 6 827-835 (2014). RTEL1 inhibits trinucleotide repeat
expansions and fragility.
Solicited Reviews and Commentaries
45. Lahue, R. S., and Modrich, P. Mutation Research 207 37-43 (1988). Methyl-directed
mismatch correction in vitro.
46. Modrich, P., and Lahue, R. S. Annu. Rev. Biochemistry 65 101-133 (1996). Mismatch repair in
replication fidelity, genetic recombination and cancer biology.
47. Lahue, R. S. and Slater, D. L. Frontiers in Bioscience. 8 s553-565 (2003). DNA repair and
trinucleotide repeat instability.
48. Lahue, R. S. ChemTracts - Biochemistry and Molecular Biology. 17:677-681 (2004).
DNA mismatch repair and trinucleotide repeat instability: the expansion connection.
49. Lahue, R. S., and Frizzell, A. Epigenetics. 7:806-10 (2012). Histone deacetylase complexes as
caretakers of genome stability
Methods Papers
50. Corrette-Bennett, S. E., and Lahue, R. S. Methods Mol. Biol. 113 121-132 (1999). Mismatch
repair assay
51. Bhattacharyya, S., Dixon, M. D., and Lahue, R. S. Methods Mol. Biol. 277 29-45 (2004).
Genetic assays for triplet repeat instability in yeast.