AbstractID: 10077 Title: Clinical experience and recent developments in the SBRT of lung cancer Image-guided hypofractionated external beam radiotherapy, often referred to as stereotactic body radiation therapy (SBRT) has become the standard of care for small inoperable lung lesions in the past few years. The excellent success of this technique has spawned trials comparing outcomes of SBRT to surgery. At MDACC we have been performing SBRT treatments for inoperable lung lesions for the past 5 years, first using an in-room CT-on-rails system and then using a Varian OBI unit with CBCT. Patients are planned using 4DCT or breath-hold CT and treated either free breathing or during a breath-hold. All patients are planned on Pinnacle using CT-based heterogeneity corrections. We do not use IMRT but do allow EDW. This presentation will discuss the imaging, planning, and treatment techniques for SBRT using both the CT-on-rails and CBCT-based setup as well as compare free breathing vs. breath hold treatment techniques. Learning Objective: 1) To understand how SBRT is different from conventionally fractionated radiation therapy. 2) To understand the challenges in treating thoracic tumors with SBRT. 3) To understand the strengths and weakness of different in-room setup techniques. 4) To understand the strengths and weakness of different respiratory management techniques. The author of this presentation receives finical support through sponsored research agreements with Philips and Accuray. The author’s institution receives financial support through a master research agreement from Varian. Equipment from all of these vendors will be mentioned in this presentation.