Unit D: Genetic Processes Chapter 5: Patterns of Inheritance - Gregor Mendel used pea plant crosses to follow the transmission of one or two traits at a time. Given what we know about chromosomes now, we know the genes for the traits he studied were carried on different chromosomes, and each gene had two alleles. Specific Expectations: D1.1: analyze, on the basis of research, some of the social and ethical implications of research in genetics and genomics. (5.3) D2.3: use the Punnett square method to solve basic genetic problems involving monohybrid crosses, incomplete dominance, co-dominance, dihybrid crosses, and sex-linked genes. (5.2, 5.3) D2.4: investigate, through laboratory inquiry or computer simulation, monohybrid and dihybrid crosses, and use Punnett square method and probability rules to analyze the qualitative and quantitative data and determine the parent genotype. (5.2, 5.3) D3.2: explain the concepts of DNA genes, chromosomes, alleles, mitosis, and meiosis, and how they account for the transmission of hereditary characteristics according to Mendelian laws of inheritance. (5.1, 5.2, 5.3) D3.3: explain the concepts of genotype, phenotype, dominance, co-dominance, recessiveness, and sex linkage according to Mendelian laws of inheritance. (5.1, 5.2, 5.3) D3.4: describe some genetic disorders caused by chromosomal abnormalities or other genetic mutations in terms of chromosomes affected, physical effects, and treatments. (5.3) 5.1: Understanding Inheritance pg. 202 - 207 Key Terms: trait, true breeding, cross, P generation, F1 generation, monohybrid cross, F2 generation, dominant, recessive, law of segregation, genotype, phenotype, homozygous, and heterozygous. Early Ideas About Inheritance Developing a Theory of Inheritance: Gregor Mendel’s Experiments Mendel’s Pea Plant The Results of Mendel’s True-Breeding Crosses The Results of Mendel’s F1 Crosses The Law of Segregation 1–6 pg. 205 1 – 12 pg. 207 Activity 5.1: Tasting is Genetic 1–3 pg. 206 Study Guide: Self Assessment 1 – 13 SG. 68 – 69 Mendel’s Crosses and the Law of Segregation (5.1) 1–3 SG. 70 – 71 One-Trait (Monohybrid) Crosses and test Crosses (5.1, 5.2) 1–3 SG. 72 – 73 Learning Check: Genotype and Phenotype Review Questions: 5.2: Studying Genetic Crosses pg. 208 - 218 Key Terms: Punnett square, test cross, dihybrid cross, law of independent assortment, and chromosome theory of inheritance. Analyzing Genetic Crosses: Punnett Squares A Punnett Square Analysis of Mendel’s Experiments Test Crosses: Determining the Genotype of a Parent That Has a Dominant Phenotype Working with Punnett Squares Practice Problems: 1 – 10 pg. 212 7 – 12 pg. 212 Learning Check: The Inheritance of Two Traits: Dihybrid Crosses Developing the Law of Independent Assortment A Punnett Square Can Model Mendel’s Results 13 – 16 pg. 215 Practice Problems: 11 – 20 pg. 216 Learning Check: The Chromosome Theory on Inheritance Sutton Links Mendel’s Work to Chromosome Segregation Review Questions: 1 – 12 pg. 218 Inquiry Inv. 5 – A: Monohybrid Crosses in Brassica rapa pg. 228 – 229 Thought Lab 5 – B: Corn Genetics pg. 230 Thought Lab 5 – C: Dihybrid Crosses pg. 231 Study Guide: The Law of Independent Assortment (5.2) 1–2 SG. 74 -75 5.3: Following Patterns of Inheritance in Humans pg. 219 - 227 Key Terms: pedigree, autosomal inheritance, autosomal dominant, autosomal recessive, genetic counselor, and gene therapy. Pedigree Autosomal Inheritance Autosomal Dominant Inheritance Huntington Disease, an Autosomal Dominant Disorder Autosomal Recessive Inheritance Cystic Fibrosis, an Autosomal Recessive Disorder Learning Check: 17 – 22 pg. 223 Genetic Tests Genetic Testing for Cystic Fibrosis and Huntington Disease Genetic Counseling Decisions About Genetic Testing Gene Therapy: A Cure for Genetic Disorders? The Future of Gene Therapy Review Questions: Activity 5.2: Creating a Pedigree 1 – 13 pg. 227 1–3 pg. 223 Study Guide: Using Pedigrees to Track Autosomal Recessive Disorders (5.3) 1 – 3 Autosomal Dominant Genetic Disorders (5.3) 1–2 SG. 76 – 77 SG. 78 Genetic Testing And Gene Therapy 1 – 3 SG. 79 – 80 Bringing It All Together SG. 81 Practice Test 1 – 13 SG. 82 – 83