M. S. RAMAIAH INSTITUTE OF TECHNOLOGY
BANGALORE
(Autonomous Institute, Affiliated to VTU)
SYLLABUS
(For the Academic year 2015 – 2016)
VII & VIII Semestre B.E.
BIOTECHNOLOGY
About the Institution:
M. S. Ramaiah Institute of Technology (MSRIT) was started in 1962 by the late Dr. M.S. Ramaiah,
our Founder Chairman who was a renowned visionary, philanthropist, and a pioneer in creating
several landmark infrastructure projects in India. Noticing the shortage of talented engineering
professionals required to build a modern India, Dr. M.S. Ramaiah envisioned MSRIT as an institute of
excellence imparting quality and affordable education. Part of Gokula Education Foundation, MSRIT
has grown over the years with significant contributions from various professionals in different
capacities, ably led by Dr. M.S. Ramaiah himself, whose personal commitment has seen the institution
through its formative years. Today, MSRIT stands tall as one of India’s finest names in Engineering
Education and has produced around 35,000 engineering professionals who occupy responsible
positions across the globe.
About the Department:
Established in 2002 the department offers a four year B.E. Biotechnology Program with an intake of
60 students and a two years PG Program, M.Tech in Biotechnology with an intake of 18 students. The
department is also a recognized Research Centre by VTU, Belgaum, offering M.Sc (Engg.) by
research and Ph.D programs. The Department has excellent infrastructure and state of the art
laboratories. All the class rooms in the department are spacious, well furnished and equipped with
LCD projectors. The department library houses ample number of books which is over and above the
central library facility. The department has 15 faculty members, 10 of them are Ph.D holders and the
rest are M.Tech/M.Pharma. Many of the faculty members have post doctoral experience in premier
institutions in India and Abroad. The faculty members have competence in core areas of
biotechnology viz. food and agricultural biotechnology, health and medical biotechnology &
environmental biotechnology and bioprocess engineering. The department research is focused towards
these core areas and funded by national and state funding agencies like DST, AICTE, VGST, VTU
and RGUHS
ORGANIZATION CHART
Dr. NVR Naidu
Principal
Dr. T.V. Suresh Kumar
Registrar (Academics)
Sri. Ramesh Naik
Registrar (Administration)
FACULTY
Designation
Faculty Name
Qualification
Specialization
Dr. Channarayappa
MSc (Agri), Ph.D.(India),
Ph.D. (USA), PDF
(USA), PGDBA
Professor &
Head
Biotechnology,
Molecular biology
interdisciplinary approach,
Agriculture
Dr. Bindu S
MSc, Ph.D., PDF (USA)
Associate
Professor
Food Biotechnology
Toxicology
Dr. Chandraprabha MN
MSc (Engg.), Ph.D.
(Engg.)
Associate
Professor
Biochemical Engineering
Environmental BT
Dr. Dhamodhar P
M.Sc, M.Phil., Ph.D.
Associate
Professor
Immunotechnology
Biochemistry
Dr. Ahalya N
MSc, M.Phil, Ph.D., PDF
Associate
Professor
Microbiology
Environmental Biotechnology
Mr. Lokesh KN
M. Pharm (Ph.D.)
Assistant
Professor
Pharmaceutical Biotechnology
Dr. Sharath R
MSc, Ph.D.,
Assistant
Professor
Plant & Animal BT
Phytochemistry & Pharmacology
Dr. Ravi Kumar YS
MSc, Ph.D., PDF
Assistant
Professor
Cancer Biology
Virology
Dr. Prabha M
MSc, Ph.D., PDF
Assistant
Professor
Medical biotechnology and
rDNA Technology
Dr. Sravanti V
M.Sc., Ph.D.
Assistant
Professor
Genomics & Proteomics,
Structural Biology
Mr. Samrat K
M. Tech
Assistant
Professor
Nano-Biotechnology,
Microbial Biotechnology
Mr. Gokulakrishna M
M. Tech
Assistant
Professor
Bio process Engineering
Mrs. Bhavya SG
M. Tech
Assistant
Professor
Enzyme Technology
Downstream processing
Mr. T P Krishna Murthy
M. Tech
Assistant
Professor
Bioinformatics, Biochemical and
Bioprocess Engineering
Dr. Pradeepa K
M.Sc., Ph.D.
Assistant
Professor
Plant biotechnology,
Pharmacognosy
Vision of the Institute is:
To Evolve into an autonomous institution of international standing for imparting quality
technical education”
Mission of the institute is:
“MSRIT shall deliver global quality technical education by nurturing a conducive learning
environment for a better tomorrow through continuous improvement and customization”
Vision of the Department is:
“To be a leading Biotechnology Engineering department that imparts quality technical
education with strong research component, to develop solutions in the field of food, health
and environment”.
Mission of the Department is:
“To provide quality technical education in a conducive learning environment to produce
professionals, researchers with a zeal for lifelong learning and a commitment to society”.
Process of deriving the vision and mission of the department
Process of Deriving the PEOs of the programme
Inputs from stakeholders
Inputs from stakeholders
Programme Educational Objectives (PEOs) of the program
PEO 1: To impart strong foundation in mathematics, basic and engineering sciences contributing to
Biotechnology.
PEO 2: To produce graduates who can pursue higher education and research in biotechnology and
allied fields.
PEO 3: To produce graduates with an ability to design, develop and implement research projects and
apply to solve problems related to areas of biotechnology.
PEO 4: To provide opportunities to students to work in multidisciplinary teams with professional
ethics, good communication, leadership skills and commitment to society.
PROGRAMME OUTCOMES
By the time of graduation a Biotechnology graduate will have ability to:
a. Apply concepts of mathematics, basic and engineering sciences.
b. Design, conduct experiments and interpret the results.
c. Design processes and program in the areas of bioprocess engineering.
d. Identify, formulate and solve problems in the field of biotechnology.
e. Use modern techniques, skills and engineering tools.
f. Exhibit interpersonal skills to function in multi-disciplinary teams and setups.
g. Become responsible citizen by understanding professional and ethical responsibilities.
h. Have effective professional communication with peers and community through preparation of
technical reports and presentations.
i. Acquire broad-based education and multidisciplinary approach in a global and societal context
j. Recognize technological changes and engage in lifelong learning.
k. Apply engineering and managerial skills in multidisciplinary teams to handle projects.
PROGRAM EDUCATIONAL OUTCOME (PEO) ASSESSMENT
The matrix given below describes assessment of PEO defined above against the outcome ak as
described by ABET (Appendix I)
Correlation between PEOs and POs
Program Outcomes
a b c d e f g h i
X X X
X
No
PEOs
j
1 To impart strong foundation in mathematics, basic
and engineering sciences contributing to
Biotechnology.
2 To produce graduates who can pursue higher X X X X X X
education and research in biotechnology and allied
fields.
3 To produce graduates with an ability to design, X X X X X X X
X X
develop and implement research projects and
apply to solve problems related to areas of
biotechnology.
4 To provide opportunities to students to work in
X
X X X X X
multidisciplinary teams with professional ethics,
good communication, leadership skills and
commitment to society.
K
X
X
X
X
Curriculum breakdown structure:
The curriculum of Biotechnology Engineering programme is so structured to include all the courses
that together satisfy the requirements of the programme specific criteria prescribed by the various
reputed universities/institutions, those offering Biotechnology course for the Baccalaureate level of
Biotechnology Engineering programme. The Course code, Course title, the number of contact hours
and the number of credits for each course are given in the following table. The courses are grouped in
line with the major components of the curriculum namely: (i) Mathematics and Basic sciences, (ii)
Basic Engineering courses, (iii) Humanities and Social Sciences, (iv) Professional core courses, (v)
Electives and (vi) industry exposure/project.
Breakup of Credits for BE Degree Curriculum. (I to VIII Semester)
Sem
I
II
III
IV
V
VI
VII
VIII
Total
HSS BS
ES
06
20
24
03
06
15
12
04
36
09
33
PSC
Professional
Electives
Other
Electives
Project / Seminar/
Internship
Total
Credits
50
14
13
21
18
18
84
03
06
03
03
15
03
03
14
14
Course Component
Humanities and Social Sciences
Basic Sciences (Mathematics, Physics, Chemistry)
Engineering Sciences (Materials, Workshop, Drawing, Computers)
Professional Subject Core
Professional Electives, relevant to the chosen specialization branch
Elective Subjects, from other technical and / or emerging subject Areas
Project Work, Seminar and / or Internship in industry or elsewhere
26
26
24
24
24
26
200
Abbreviation
HSS
BS
ES
PSC
Prof. Elective
Other Elective
Project/Seminar
Credits %
7.5
18.0
16.5
42.0
7.5
1.5
7.0
Different stakeholders and their interactions contributed for establishment of outcome based
education.
Institute Vision and Mission
Feedback
Faculty
Programme Educational
Objectives
Student
Programme Outcomes
Alumni
Employer/Industr
y
Department Vision and
Mission
Graduate Attributes
Statutory bodies such
as UGC, AICTE, VTU
Professional bodies
such as IBE & ASABE
Also GATE
Board of Studies for the Term 2015-2016
1. Head of the Department concerned (Chairman, BOS)
2. At least four faculty members at different levels covering different specializations nominated by the
Academic Council
3. Special invitees:
1) Two experts in the subject from outside the college
2) One expert from outside the college, nominated by the Vice Chancellor
3) Two representative from industry/corporate sector allied area relating to placement
nominated by the Academic Council
4) One postgraduate meritorious alumnus to be nominated by the Principal
Sl.
No.
1
Name
Members of Board of Studies for the year 2015-16
Institution & Address
Dr. Channarayappa
2
Dr. Shivaprakash MK
3
Dr. B S Gowrishankar
4
Dr. Nagendra HG
5
Dr. Venkata Ranganna
6
Dr. Manjunath Ramarao
7
Dr. Bindu S
8
Dr. Chandra Prabha MN
9
Dr. P Dhamodhar
10
Dr. Sharath R
Prof. & Head, Dept. of Biotechnology,
MSRIT, Bangalore. Mob: 9449425111
Professor and Head, Department of
Microbiology, University of Agricultural
Sciences, GKVK Campus, Bengaluru 560065
Mob: 9845838359
Prof. & Head , Dept. of Biotechnology, SIT,
Tumkur, Mob: 9844461940
Professor and Head of Biotechnology, Sir M
Visvesvaraya Institute of Technology,
Krishnadevaraya Nagar, Hunsamarnahalli, via
Yelahanka, Bangalore-562157
Mob: 9916303565
Lead Scientist, M/s. Connexious Life Sciences
Pvt. Ltd.,Bangalore-78,Mob: 9844117742
Email: marikunte@yahoo.com
Group Director and Head, Biocon-BristolMyers Squibb India Ltd. Biocon-Park, IV
Phase Bommasandra, Bangalore-560099
Mob: 9845238679 email:
Associate Professor, Dept. of Biotechnology,
MSRIT, Bangalore. Mob: 9448704641
Associate Professor,Dept. of Biotechnology,
MSRIT, Bangalore, Mob: 9845785174
Associate Professor,Dept. of Biotechnology,
MSRIT, Bangalore, Mob: 9880341651
Asst. Professor,Dept. of Biotechnology,
MSRIT, Bangalore, Mob: 9845884959
Chairman /
Member
Chairman
Member
(Other Institutions)
Member
(Other Institutions)
Member
(VTU Nominee)
Member
(Industry)
Member
(Industry)
Member
Alumnus Member
Member
Member
SCHEME OF TEACHING FOR THE ACADEMIC YEAR 2015 – 2016
Sl.
No
1
2
3
4
5
6
7
8
9
Sl.
No
1
2
3
4
5
6
7
8
9
Subject
Code
BTMAT301
BT302
BT303
BT304
BT305
BT306
BT307L
BT308L
BT309L
Subject
Code
BTMAT401
BT402
BT403
BT404
BT405
BT406
BT407L
BT408L
BT409L
*L – Lecture,
Subject Title
Numerical & Mathematical Biology
Unit Operations
Bioprocess Principles & Calculations
Biochemistry
Microbiology
Cell Biology & Genetics
Unit Operations Lab
Biochemistry Lab
Microbiology Lab
Total
Subject Title
Biostatistics & Biomodeling
Heat & Mass Transfer
Bioanalytical Techniques
Biochemical Thermodynamics
Molecular Biology
Human Physiology
Heat & Mass Transfer Lab
Bioanalytical Techniques Lab
Molecular Biology Lab
Total
T – Tutorial,
P- Practicals
III SEMESTER
Teaching
Dept.
L
Mathematics
4
BT
3
BT
3
BT
4
BT
4
BT
3
BT
0
BT
0
BT
0
21
IV SEMESTER
Teaching
Dept.
L
Mathematics
4
BT
3
BT
4
BT
3
BT
3
BT
3
BT
0
BT
0
BT
0
20
T
0
0
1
0
0
1
0
0
0
2
T
0
1
0
1
1
0
0
0
0
3
Credits*
P
0
0
0
0
0
0
1
1
1
3
Total
4
3
4
4
4
4
1
1
1
26
Credits*
P
0
0
0
0
0
0
1
1
1
3
Total
4
4
4
4
4
3
1
1
1
26
Contact hours
Classification
4
3
5
4
4
5
2
2
2
31
BS
PSC
PSC
BS
BS
PSC
PSC
PSC
PSC
Contact hours
Classification
4
5
4
5
5
3
2
2
2
32
BS
PSC
ES
ES
PSC
PSC
PSC
PSC
PSC
Sl.
No.
1
2
3
4
5
6
7
8
9
Sl.
No.
1
2
3
4
5
6
7
8
9
Subject Code
BT501
BT502
BT503
BT504
BT505
BTPE
BT506L
BT507L
BT508L
Immunology
Agricultural Biotechnology
Bioinformatics
Structural Biology
Genetic Engineering
Elective – A
Immunology Lab
Bioinformatics Lab
Genetic Engineering Lab
Total
Subject Code
BT601
BT602
BT603
BT604
BTPE
BTPE
BT605L
BT606L
BT607L
*L – Lecture,
Subject
Subject
Enzyme Technology
Upstream Process Technology
Bio-reaction Engineering
Genomics and Proteomics
Elective - B
Elective – C
Enzyme Technology Lab
Upstream Process Technology Lab
Bio-reaction Engineering
Total
T – Tutorial,
P- Practicals
V SEMESTER
Teaching
Dept.
L
BT
3
BT
3
BT
3
BT
3
BT
3
BT/ChE/CSE
3
BT
0
BT
0
BT
0
18
T
0
0
1
1
1
0
0
0
0
3
Credits*
P
0
0
0
0
0
0
1
1
1
3
VI SEMESTER
Teaching
Credits*
Dept.
L
T
P
BT
3
1
0
BT
3
0
0
BT
3
1
0
BT
4
0
0
BT
3
0
0
BT
3
0
0
BT
0
0
1
BT
0
0
1
BT
0
0
1
19
2
3
Total
3
3
4
4
4
3
1
1
1
24
Total
4
3
4
4
3
3
1
1
1
24
Contact Hours
Classification
3
3
5
5
5
3
2
2
2
30
PSC
PSC
PSC
PSC
PSC
PSE
PSC
PSC
PSC
Contact
Hours
5
3
5
4
3
3
2
2
2
29
Classification
PSC
PSC
PSC
PSC
PSE
PSE
PSC
PSC
PSC
Electives - A
Sl.
No.
1
2
3
Subject
Code
BTPE01
BTPE02
BTPE03
Subject
Programming in JAVA & C++
Environmental Biotechnology
Transport Phenomena
Teaching
Dept.
BT/CSE
BT
BT/ChE
1
2
3
BTPE04
BTPE05
BTPE06
Microbial Biotechnology
Animal Biotechnology
Biomaterials
BT
BT
BT
1
BTPE07
BT
2
3
BTPE08
BTPE09
Advance programming using
CAD & MAT Lab
Food Biotechnology
Research Methodology
*L – Lecture,
T – Tutorial,
P- Practicals
BT
BT
L
3
3
3
T
0
0
0
Electives – B
3
3
3
Electives – C
3
3
3
Credits*
P
0
0
0
Total
3
3
3
Contact
hours
3
3
3
Classification
PSE
PSE
PSE
0
0
0
0
0
0
3
3
3
3
3
3
PSE
PSE
PSE
0
0
3
3
PSE
0
0
0
0
3
3
3
3
PSE
PSE
Sl. No.
1
2
Subject
Code
BT701
BT702
3
4
5
6
7
8
BT703
BT704
BT705
BTPE
BT706L
BT707L
Sl. No.
Subject
Code
1
2
3
1
BTPE10
BTPE11
BTPE12
BTOE01
*L – Lecture,
Subject
Bioprocess Control & Automation
Downstream Process Technology &
Bioseparation Techniques
Pharmaceutical Biotechnology
Bioprocess Equipment Design
IPR
Elective – D
Bioprocess Control & Automation Lab
Downstream Process Technology Lab
Total
Subject
Forensic Science
Tissue Engineering
Medical Biotechnology
Principles of food processing &
preservation
T – Tutorial,
P- Practicals
VII SEMESTER
Teaching
Dept.
L
BT
3
BT
3
BT
BT
BT
BT
BT
BT
Credits*
T
P
Total
1
0
4
1
0
4
4
0
0
3
1
0
3
0
0
3
0
0
0
0
1
0
0
1
19
3
2
ELECTIVES
Teaching
Credits*
Dept.
L
T
P
Elective – D
BT
3
0
0
BT
3
0
0
BT
3
0
0
Other Institutional Electives (OIE)
BT
3
0
0
Contact
hours
5
5
Classification
PSC
PSC
4
4
3
3
1
1
24
4
5
3
3
2
2
29
PSC
PSC
HSS
PSE
PSC
PSC
Classification
Total
Contact
hours
3
3
3
3
3
3
PSE
PSE
PSE
3
3
OIE
VIII SEMESTER
Sl.
No.
1
Subject
Code
BT801
Subject
Bioethics and Biosafety
2
BT802
Plant design, Economics and Entrepreneurship
3
OIE
4
5
BT804
BTPE
Other institutional elective
Project work
Elective -E
Teaching
Dept.
BT
L
3
Credits*
T
P
0
0
BT
3
0
Other
Depts.
BT
BT
3
0
3
12
Total
Contact hours
Classification
Total
3
3
HSS
0
3
3
HSS
0
0
3
3
OIE
0
0
0
14
0
14
14
3
26
28
3
40
PW
PSE
0
0
0
0
0
0
3
3
3
3
3
3
PSE
PSE
PSE
ELECTIVE-E
1
2
3
BTPE13 Drug Design and Development
BTPE14 Nano Biotechnology
BTPE15 Operations Research & Management
*L – Lecture,
T – Tutorial,
P- Practicals
BT
BT
BT
3
3
3
Sub Code
Credits
BIOPROCESS CONTROL AND AUTOMATION
: BT 701
CIE
: 50 Marks
: 3:1:0
SEE
: 50 Marks
Prerequisite: Bioreaction Engineering
Course Coordinators: Mr. Gokulakrishnan & Dr Chandraprabha MN
Course Objectives: this course will provide:
1. To study the biochemical instrumentation and estimation techniques of process parameters.
2. To study the process dynamics of first order, second order and first order system in series
3. To study the integration of individual components into a closed loop control system and the
effects of components and variables on the controller response.
4. To study the concept of stability of control systems and factors affecting them.
Course content:
UNIT-1
Introduction: Monitoring and control of bioreactors, Biochemical Reactor Instrumentation, physical,
chemical and bio-chemical parameters, Introduction to flow, pressure, temperature, pH, foam, DO,
redox and level measurements, sensors for medium and gases. Online and offline measurements of
cells, substrates and products, Process modeling, state and parameter estimation techniques for
biochemical process.
UNIT-2
Systems and Process Dynamics: Process characteristics, I order system-examples, mercury in glass
thermometer, level, mixing. Linearisation, I order system in series, interacting and non-interacting
systems. Second order system with under damping, derivation of transfer function for various systems,
dead time, response of I and II order over damped and under damped systems, to step, ramp, impulse
(pulses) and sinusoidal changes. Numericals
UNIT-3
Controllers and Final Control Elements: Controllers-discontinuous and continuous, two position
control, proportional, derivative, integral control; proportional Reset (integral) (P+I); proportional
+rate (derivative (P+D); proportional+reset+rate controller (PID), actuators, positioners, valve body,
valve plugs, Valve characteristics, final control elements. Transfer functions for controllers and final
control element, numerical.
UNIT-4
Transient Response of Closed Loop Systems: Block diagram reduction, block diagram & Transfer
functions for servo and regulator problems. Transient response of I and II order processes for set point
changes and load changes with proportional, PI, PD and PID controllers, numericals.
UNIT-5
Stability of Closed Loop Control Systems Concepts of stability, stability criteria, Routh test for
stability, Root-locus method, Bode plots and stability criteria, tuning of controllers, numericals.
Text Books:
1. Donald R. Coughanowr (2013) Process Systems Analysis and Control, Mcgraw-Hill, 3rd ed.,
2. Pauline MD (2009) Bioprocess engineering principles, Reed Elsevier India.
Reference Books:
1. Bailey and Ollis (2010) Biochemical engineering fundamentals. McGraw Hill (2nd Ed)
1
2. Shuler and Kargi (2002) Bioprocess engineering, 2nd ed., Prentice Hall.
3. Tarun K Ghosh (ed.) (1984) Biotechnology and bioprocess engineering: Proceedings, VII
international biotechnology symposium. Delhi.
4. Wankat PC (2005) Rate controlled separations, 1st ed., Springer.
5. George Stephanopoulous (2009) Chemical process control 1st ed., Prentice Hall of India.
Indirect
Assessment
Methods
CIE
Assignment
Surprise
Test/ Quiz
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where
Max
whom
(Frequency in marks
the course)
Thrice(Average
Internal
of the best two
assessment
30
will be
tests
computed)
End of course
survey
Students
Contributing
to Course
Outcomes
Blue books
1,2,3&4
Assignment
reports
Blue
books/Quiz
answer
sheets
Once
10
Once
10
End of course
(Answering 5
of 10
questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
---
Students
Standard
examination
Evidence
collected
1&4
2,3&4
Course Outcome: On completion of this course student will have improved ability:1: Determine the parameters to be measured and controlled in the bioreactor.
2: Predict the response of first order, second order and first order system in series for various input
change
3: Analyze the different control actions involved in the bioreactor.
4: Evaluate the transient response of first and second order systems for load change and to predict the
stability of the system.
Mapping of course outcome with program outcome
Course Outcomes
a
b
X
c
X
X
X
X
X
X
X
CO1
CO2
CO3
CO4
Program Outcomes
d
e
f
g
h
X
i
X
X
X
j
k
2
DOWNSTREAM PROCESS TECHNOLOGY & BIOSEPARATION
TECHNIQUES
Sub Code
: BT 702
CIE
: 50 Marks
Credits
: 3:1:0
SEE
: 50 Marks
Prerequisite: Unit operations & Bioanalytical Techniques
Course Coordinators: Mr. Samrat K & Dr. Ahalya N
Objectives of the course: The course will provide:
1. Introduction to downstream processing, its scope and its applications in product isolation,
characterization and purification on large scale, economics of downstream processing.
2. Physiochemical basis of Bioseparation for macromolecules like DNA, Proteins, etc of
commercial interest.
3. Role of important unit operations like centrifugation, filtration, precipitation/ extraction,
downstream prospective.
4. Final product formulation and finishing operations through crystallization and drying techniques.
Course Content:
UNIT-1
Role of downstream processing in biotechnology: Role and importance of downstream processing
in biotechnological processes. Problems and requirements of bioproduct purification. Economics and
downstream processing in Biotechnology. Cost cutting strategies, characteristics of biological
mixtures, process design criteria for various classes of bioproducts (high volume, low value products
and low volume, high value products), physicochemical basis of bio separation processes.
UNIT-2
Primary separation and recovery process: Cell disruption methods for intracellular products,
removal of insolubles, biomass (and particulate debris) separation techniques; flocculation and
sedimentation, centrifugation and filtration methods.
UNIT-3
Enrichment operations: Precipitation methods with salts, organic solvents, and polymers, extractive
separations. Aqueous two-phase extraction, supercritical extraction; In situ product removal/integrated
bio processing.
UNIT-4
Membrane science and technology: Use of membrane diffusion as a tool for separating and
characterizing naturally occurring polymers; solute polarization and cake formation in membrane ultra
filtration – causes, consequences and control techniques; enzyme processing using ultra filtration
membranes; separation by solvent membranes; ultra filtration and reverse osmosis.
UNIT-5
Final product formulation and finishing operations: Hybrid Separation Techniques (Membrane
chromatography, Electrochromatography, etc). Crystallization – Principles, Nucleation, Crystal
Growth – Kinetics, crystallization of proteins. Drying and lyophilization in final product formulation.
Text Books:
1. Scopes R.K (1993) Protein Purification, IRL Press.
2. Upadhyay, Upadhyay, and Nath (2003) Biophysical Chemistry Principles and techniques,
Himalaya Publishing House.
3. Sivasankar B (2005) Bioseparations: Principles and Techniques, Eastern Economy Edition.
3
Reference Books:
1. Wankat PC (1990) Rate controlled separations Elsevier
2. Belter PA and Cussier E (1985) Bioseparations, Wiley
3. Product Recovery in Bioprocess Technology - BIOTOL Series, VCH, 1990
4. Asenjo J and Dekker M(1993) Separation processes in Biotechnology
5. Okotore RO (2002) Basic Separation Techniques in Biochemistry, New age publishing Co.
6. Robert K. Scopes (ed.) (2004) Protein purification principles and practice, Springer International
7. Simon Roe (2006) Protein purification Techniques (2nd Edn) Oxford University Press.
Assessment and Evaluation vis-à-vis Course Outcomes:
Indirect
Assessment
Methods
CIE
To
whom
When/ Where Max
(Frequency in marks
the course)
Thrice(Average
of the best two
30
will be
computed)
Internal
assessment
tests
Assignment
Surprise
Test/ quiz
SEE
Direct
Assessment
Methods
What
End of course
survey
Students
Contributing
to Course
Outcomes
Blue books
1,2,3&4
Once
10
Assignment
reports
4&5
Once
10
Quiz answers
2,3&4
End of course
(Answering 5
of 10
questions)
100
Answer scripts
1,2,3&4
End of course
-
Questionnaire
---
Students
Standard
examination
Evidence
collected
Course Outcome: On completion of this course student will have improved ability to:
1: Apply downstream processing economics for product development.
2: Identify appropriate unit operations based on nature of biomolecules or complex bioprocess
parameters.
3: Apply appropriate unit operation for isolation, purification and characterization of bioproduct.
4: Evaluate different unit operations for product crystallization and Drying.
Mapping of course outcome with program outcomes
Course
Outcomes
1
2
3
4
a
b
c
X
X
X
X
X
X
d
X
X
X
X
Program Outcome
e
f
g
h
i
j
k
X
X
X
X
4
Sub Code
Credit
PHARMACEUTICAL BIOTECHNOLOGY
: BT 703
CIE
: 4:0:0
SEE
: 50 Marks
: 50 Marks
Prerequisite: Nil
Course Coordinators: Mr. Lokesh K N and Dr. Dhamodhar
Objectives of the course: The course will provide:
1. Introduction Pharmaceutical biotechnology it scope. Drug development process of protein of
peptide based therapeutics & and some important aspects of drug discovery and important
regulatory affairs.
2. In depth information about protein or peptide based therapeutics in immune therapy, different
Hemopoeitic conditions, cancer etc.
3. Exploring the novel area of biopharmaceutical like controlled drug delivery systems/ Novel
drug delivery.
1. Essential information regarding formulation of biopharmaceutical in order to enhance their self
life/ Pharmacodynamics/ pharmacokinetic properties.
Course Content:
UNIT-1
Introduction to Pharmaceutical Biotechnology: scope, Development of drugs and pharmaceutical
industry-organic therapeutic agent’s uses and economics, regulatory bodies, introduction to drugs and
cosmetics act, overview and important schedule C and C1, schedule M, Schedule Y.
UNIT-2
Pharmacokinetics
and
Pharmacodynamics:
Introduction to
pharmacokinetics
and
pharmacodynamics, Drug metabolism- half-life of drugs, physico chemical principles,
Biotransformation/pharmacokinetic studies, elimination and distribution of protein therapeutics,
pharmacodynamics principles.
UNIT-3
Recent Advances in Pharmaceutical Biotechnology: Introduction to nutraceuticals, edible vaccines,
Introduction to Health Bioinformatics, pharmacogenomics. Commercially available important
diagnostic kits, diagnostic kits for detection of blood sugar, HIV, Malaria etc, recent advances in
diagnostic kits.
UNIT-4
Manufacturing Principles: Manufacturing facilities, Clean room concept introduction to recombinant
DNA technology and production of important therapeutic biopharmaceutical like haemopoietic growth
factors (interleukins, erythropoietin’s), therapeutic hormones (insulin, human growth factor) and blood
products.
UNIT-5
Formulations of Biopharmaceutical, Analysis and Control: Manufacturing facilities, excipients
used in parental formulations, shelf life of protein based pharmaceuticals, delivery of protein ( rate
controlled, target specific, site specific, soluble carrier system etc) Analytical methods for the tests for
various drugs and pharmaceuticals, different packaging techniques, quality control.
Textbooks:
1. Industrial Pharmaceutical Biotechnology by Heinrich Klefenz, Wiley-VCH edition.,1995
2. Gary Walsh (1998) Biopharmaceuticals: Biochemistry and Biotechnology.
5
Reference Books:
1. Gregory Bock, Dalia Cohen, Jamie Goode, Novartis and J. Craig Venter (2001) From Genome
to Therapy: Integrating New Technologies with Drug Development - No. 229.
2. Susanna Wu-Pong, Yongyut Rojanasakul, and Joseph Robinson (2006) Biopharmaceutical
Drug Design and Development.
1. Herbert A Kirst, Wu-Kuang Yeh, Milton J (2001) Enzyme technologies for pharmaceutical
and biotechnological applications.
Assessment and Evaluation vis-à-vis Course Outcomes:
Indirect
Assessment
Methods
CIE
To
whom
When/ Where
(Frequency in
the course)
Max
marks
Evidence
collected
Contributing to
Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3&4
assignment
once
10
Assignment
reports
2,3&4
Once
10
Quiz answers
1,2,3
End of course
(Answering 5
of 10
questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
Surprise
quiz
SEE
Direct Assessment Methods
What
Students
Standard
examination
End of course
survey
Students
Course Outcome: On completion of this course student will have improved ability:1: Correlate the importance of Pharmacy with other basic science for development of novel therapeutics and
diagnostics.
2: Assess pharmacokinetic and Pharmacodynamic profile of new drug candidates.
3: Apply GMP / GLP guidelines in development or processing of Biopharmaceuticals.
4: Competent to serve in Pharmaceutical Industry/clinical research organization (CRO).
Mapping of course outcome with program outcomes
Program Outcome
Course Outcomes a
b
c
D
e
f
g
h
1
x
x
x
2
x
x
x
x
3
x
x
x
4
x
i
x
j
x
k
x
6
Sub Code
Credit
BIOPROCESS EQUIPMENT DESIGN
: BT 704
CIE : 50 Marks
: 3:1:0
SEE : 50 Marks
Prerequisite: Unit operations & Heat and Mass transfer
Course Coordinators: Mr. Samrat K & Dr. Chandraprabha MN
Course Objectives
1. To study the basics of equipment design concepts and piping design.
2. To study the various aspects involved in pressure vessel and auxiliary components required for
vessel design.
3. To study the Design and analysis of bioreactors.
4. To study the Design aspects of heat and mass transfer equipments.
Course Content:
UNIT-1
Introduction to principles of designing and flow sheet preparation: Nature of design, design
factors, degrees of freedom, design variables, optimization, nature of process equipment, general
design procedure, basic considerations in design, standards, codes, and their significance, equipment
classification and their selection, design pressure, design temperature, design stress, design loads,
review of fabrication techniques, economics and environmental considerations in design procedure.
Piping design. Materials of construction. Sketching techniques, Equipment symbols, Process Flow
sheets. Safety considerations in design.
UNIT-2
Pressure vessel design: Design of unfired pressure vessels: Types of pressure vessels, codes and
standards for pressure vessels (IS: 2825; 1969) Proportioning of pressure vessels, selection of L/D
ratio, optimum proportions of vessels Complete Design as per IS: 2825; 1969 involving shells:
cylindrical, spherical. Vessel Component Design: Study, Selection and design of various heads,
Opening/ nozzles, and manholes. Gasket, flange and bolt design. Design of Vessel support.
UNIT-3
Design of Bioreactors: Overview of bioreactors, basic design equation for bioreactors. Functional
design- Based on the type of bioreactor (batch reactor MFR) and cell growth kinetics and performance
equation, determination the volume of the reactor, according to H/D ratio determine height and
diameter. Mechanical design- Thickness of the shell (cylindrical, spherical), thickness of top & bottom
cover, flange calculations – width and thickness of gasket, number of bolts, bolts circle diameter and
bolt diameter. Agitator design- diameter of agitator, height of agitator, type of blade and power
required (power rating) to run the agitator.
UNIT-4
Design of Heat Exchangers: Introduction to heat exchanger, Functional design – Energy balance
equation, log mean temperature difference (co-current, counter counter), Heat transfer coefficients
(inside, outside & overall), area, length, number of tubes, tube sheet diameter, pitch type, diameter of
tube sheet (STHE).Pressure drop calculations.
UNIT-5
Design of Distillation column and evaporators: Introduction, reflux considerations, total reflux,
minimum reflux, optimum reflux ratio, feed point location, McCabe-Thiele method – procedure,
Distillation column design, Plate contactors-Bubble Cap, sieve plate, Valve plates, Diameter of
column. Design of Evaporator – Single effect, Numerical problems.
7
Textbooks:
1. Coulson JM, Richardson JF and Sinnott RK (2006) ‘Chemical Engineering Vol. 6 - Design,
Pergamon Press.
2. Brownell LE and Young EH (2009) Process Equipment Design - Vessel Design, John Wiley
and Sons, Inc.
3. Tapobrata Panda., Bioreactors: Analysis and Design, 1st Edition, Tata McGraw Hill Education
Private Limited, New Delhi, 2011.
4. S Thakore, B Bhatt., Introduction to Process Engineering And Design Paperback , McGraw
Hill Education (India) Private Limited 2007.
Reference Books:
1. Ludwig EE (2010) Applied Process Design for Chemical and Petrochemical Plants, Vol. 1 and
2, 3rd Ed., Elsevier India.
2. Walas SM (1995) Chemical process equipment: selection and design ButterworthHeinemann.
3. Indian standards Institution, Code for unfired pressure vessels, IS – 2825.
4. Bhattacharya BC (2012) Introduction to chemical equipment design, 1st ed., CBS Publications.
5. Joshi MV (2003) Process Equipment Design 3rd ed., Macmillan India.
Contributing
to Course
Outcomes
Blue books
1,2,3&4
Assignment
Once
10
Assignment
reports
2&3
CIE
Evidence
collected
Students
Surprise
Test/
Tutorial Test
Once
10
Blue Books
2&3
SEE
Indirect
Assessmen
t Methods
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where Max
whom (Frequency in marks
the course)
Thrice(Average
Internal
of the best two
assessment
30
will be
tests
computed)
Standard
examination
End of course
(Answering 5
of 10
questions)
100
Answer scripts
1,2,3&4
End of course
-
Question-naire
---
End of course
survey
Students
Course Outcome: On completion of this course students will have improved ability to:
1: Analyze the design concepts.
2: Design the pressure vessel and its auxiliary units as per standard.
3: Analyze the various parameters for bioreactor design.
4: Design various heat and mass transfer equipments.
Mapping of course outcome with program outcomes:
Program Outcome
Course
Outcomes
a
b
c
d
e
f
g
h
i
j
k
1
X
X
2
X
X
X
3
X
X
X
4
X
X
X
8
INTELLECTUAL PROPERTY RIGHTS
Sub Code: BT705
CIE : 50 Marks
Credits : 3:0:0
SEE : 50 Marks
Prerequisite:
Course Coordinators:
Course Objectives: The objectives of this course are:
1. To study the importance of IP in the research and development and differentiate between the
various categories of IP protection
2. To study the conceptual and legal framework, and procedural requirements relating to
trademarks and copyrights.
3. To develop among students awareness about the patent law in India and spell out the
procedural mechanism involved in obtaining a patent besides licensing of patents and
compulsory licensing.
4. To discuss the patenting of living organisms
Course Content:
UNIT-I
Introduction to IPR: History of IPR. Need of IP. Globalization, International organization for IP
control: GATT, WTO, WIPO & TRIPS. IPR in Research and Development.
Introduction to different forms of IPR: Copyrights, Trademarks, Industrial designs, patents,
Geographical Indications, Traditional Knowledge, Plant varieties, Trade Secrets.
UNIT-II
Trade Marks: Nature, Essentials, Protection, Trademarks, Service marks and Laws. Procedure for
trade mark registration, Case Studies on Trademarks: Related to Biotechnology and allied industries.
Copy Right: Characteristics and Requirements; Copyright law in India Subject matter of copyright
Neighboring rights, Procedure for copyright registration, Ownership; Infringement of Copyright. Case
Studies on Copyrights: Related to Biotechnology and allied industries.
UNIT-III
Patents: patent as an intellectual property, Brief history of patents-Indian and global scenario,
Principles underlying Patent law. Patentable Subject Matter, Patent is a Negative Right, infringement
of patents, patent life cycle, Beneficiaries of Patents patent granting authority, literature scanning for
possibility of IP rights, decision to go for IP protection or not, and consideration of choice of IP
protection, disclosure, inventors interview, Process and Product Patents. Ideas: Generation and review
of ideas, documenting ideas,
UNIT-IV
Patent application procedure & drafting
Patent Drafting: Filing requirements. Patent application Indian and global scenario, types of patent and
patent application application, Patents and Patent search, invention record, public disclosure,
Processing of Patent application, Patent Drafting, Patent Examination Patent Co-operation
Treaty Patent attorney and Agent. patent prosecution, patent Revocation. Cost of getting and
maintaining patents – in India, US and other countries, role of patent agents and attorneys, possibility
of IPR as a career. Case studies Related to Biotechnology and allied industries.
UNIT-V
Origins of patent law in biotechnology, Bio-piracy: case study, Diamond versus Anand Chakra borty
etc. Patenting biotech products. Complex issues, moral issues, current patent practice and necessity of
clear guidelines in biotechnology patent law, examples, National Biodiversity protection initiatives;
9
Convention on Biological Diversity; International Treaty on Plant Genetic Resources for Food and
Agriculture;
Commercial Potential of Biotech Inventions Patenting Biotechnological inventions. Microorganisms,
Plant Varieties Protection and Protection of Traditional Knowledge
Text Books:
1. Acharya NK (2007) Text book on Intellectual Property Rights, Asia Law house, 4th edn.
2. Deborah E Bouchoux,(2005) Intellectual Property Rights, Delmar Cengage learning
3. Patent Fundamentals for Scientists and Engineers, Thomas T Gordon and Arthur S Cookfair, CRC
Press (1995).
Reference Books:
1. Wadehhra BL (2002) Intellectual Property Law Handbook, Universal Law Publishing Co. Ltd.
2. Prabuddha Ganguli (2001) Intellectual Property Rights, TMH Publishing Co. Ltd.,
3. Manish Arora (2007) Guide to Patents Law, Universal Law Publishing, 4th Ed.
4. Singh K (2000) Intellectual Property Rights on Biotechnology. BCIL, New Delhi.
5. Intellectual Property Laws (Bare Act with short comments), Professional Book Publishers, 2007
6. Channarayappa (2006) Molecular Biotechnology: Principles and Practices University Press,
India. Worldwide publishing: CRC Press.
7. Anonymous (2006) The Patents Act, 1970 (Bare Act with Comments) as amended by Patents
(Amendment) Rules 2006 w.e.f. 5-5-2006, Commercial law Publishers (India) Pvt. Ltd..
8. Anonymous (2006) Course materials of “Advanced Training Programme on Management of
Intellectual Property Rights In Biotechnology for Small and Medium Sized Enterprises’
conducted by WIPO and BCIL in Bangalore during 5-7.
Ass
ess
me
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
30
Blue books
1,2,3&4
Twice( Average of
the two will be
computed)
10
Assignment
reports
1,2,3&4
Once
05
Case
solutions
1,2,3&4
Surprise quiz
Once
05
Quiz
answers
1,2,3&4
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
1,2,3&4
Class-room
open book
assignment
Case analysis
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
When/ Where
To
What
(Frequency in the
whom
course)
Internal
Thrice(Average of
assessment
the best two will
tests
be computed)
End of course
survey
Students
Students
10
Course Outcomes: At the end of this course, students should be able to:
1. Identify the different types of IP and scope of protection, and discuss the role of the international
intellectual property rights system
2. Distinguish the key differences between trade mark and copy right and conversant with the
procedures used to protect copyright and trademark.
3. Apply the procedure involved in drafting patent application and identify activities that constitute
patent infringement and discuss the remedies available to the patent owner
4. Discuss the crucial role of IP in biotechnological organizations for the purpose of product and
technology development
Mapping of course outcome with program outcomes
Course outcome
1
2
3
4
a
b
c
d
Program Outcome
e
f
g
h
X
X
X
X
X
X
X
X
X
X
i
X
j
X
X
k
X
X
X
11
Sub Code
Credits
FORENSIC SCIENCE
: BTPE10
CIE : 50 Marks
: 3:0:0
SEE : 50 Marks
Prerequisite: Biochemistry
Course Coordinators: Dr. Sharath, R. and Mr. Samrat K
Course Objectives:
1. To know the importance, scope and Different laboratory services in of forensic Science.
2. Understand the concept criminalistics, investigation procedure and evidence collection.
3. To know the different areas and their duties and importance of digital photography and ethics.
4. Understand the necessary theoretical and practical background in all the primary areas of
criminalistics for a career in forensic science.
Course Content:
UNIT-I
INTRODUCTION: Introduction, Definition and Scope, History and Development of Forensic
science, basic Principles of Forensic Science. Organization of crime Laboratory services, services
provided by full service crime laboratories, Physical Science unit, Biological Unit, Firearms Unit,
Documentation Examination Unit- Function and Duties Performed by each unit and lab.
UNIT-2
FORENSIC CRIMINALISTICS in forensic science, The Crime Scene investigation- Making and
recording observations (including sketches with measurements and digital photographs), Chain of
Custody, Locard Exchange principle, Evidences and Collection techniques, Firearms, Trace evidence
and contact evidence- targeting potential traces, recovery of trace material assessment of significanceHair, fiber and Paint. Marks and impressions, Drug of abuse. Ploygraphy.
UNIT-III
FORENSIC BIOLOGY: Forensic Pathology: Rigor mortis, Lovor mortis, Algor mortis. Forensic
Anthropology, Forensic Toxicology- Alcohol & it relationship to human anatomy & metabolism,
Testing for drugs and poisons using pH. TLC, immunoassay, & chemical tests, Forensic Entomology,
Forensic Psychiatry, Forensic Odontology, Forensics Engineering, forensic serology, Wild Life
forensic, DNA Analysis, Dactyloscopy, Finger prints: history, fundamental principle of Fingerprints,
Classification and patterns, AFIS, Mrthod of Detecting fingerprint.
UNIT-IV
FORENSIC DIGITAL IMAGING: Introduction, Digital cameras and forensic imaging, image
acquisition technique. Methods and applications, Authenticity, image processing. Technical
investigation on image storage media. Digital image processing- sharpening, contrast, blur soomthing,
digital videos and scanners, presenting pictures in courtroom, internet crime. Forgery and
stegnography, Voice analysis. Detecting compression and forgeries and Maintaining Records, Hand
Writing analysis. Computerized facial reconstruction.
UNIT-V
FORENSIC ETHICS: Introduction and importance of Professional ethics in Forensic Science,
organizational forensic Science ethics, Code of ethics in Forensic Science Practice. Standard for Good
Forensic practice. Ethical problems in ethical forensic sciences. Ethical Dilemmas
Text Books:
1. Jay Siegal, Geoffrey Knuper, Pekku Saukko (2000): Enyclopedia of Forensic Sciences, Threevolume SET1-3, Elsvier book publication.
12
2. Max M. Houck (2007): Forensic Science: Modern methods of solving problems, Praeger West
Port London,
3. Ayn Embar-Seddon, Allan D. Pals (2009): Forensic Science, Salem Press, Inc. Paradena,
California
4. Jami J. St Clair (2002): Crime Laboratory Management- Academic Press.
Reference Books:
1. Richard Saperstein(2001): Criminalistics: An Introduction to Forensic Science –Prentice Hall,.2
2. David Ellen (2003): The Scientific Examination of Documents Methods and Techniques-, Taylor
and Francis.
Indirect
Assessmen
t Methods
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3 &4
Class-room
open book
assignment
Twice( Average
of the two will
be computed)
10
Assignment
reports
1,2,3 &4
Once
05
Case
solutions
1,2,3 &4
Surprise
quiz
Once
05
Quiz
answers
1,2,3 &4
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3 &4
End of course
-
Questionnaire
1,2,3 &4
Case
analysis
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To whom When/ Where
(Frequency in
the course)
End of course
survey
Students
Students
Course Outcomes: on completion of this course students will
1: Apply the principles of instruction to generate competent, credible forensic scientists.
2: Influence the development of forensic science end-to-end service delivery policies in relation to
scientific quality.
3: Evaluate the professional codes of ethics outlined by various professional forensic science
organizations.
4: Formulate a complete and logical plan for data analysis in forensic science research
Mapping of course outcome with program outcomes
Program Outcome
Course outcome
a
b
c
d
e
f
g
h
1
X
X
X
2
X
X
X
3
X
X
X
4
X
X
i
j
k
X
X
X
13
Sub Code
Credits
TISSUE ENGINEERING
: BTPE11
CIE
: 50 Marks
: 3:0:0
SEE
: 50 Marks
Prerequisite: Cell biology
Course Coordinators: Dr. Prabha M
Course Objectives: The course will provide knowledge on:
1. The study of development, properties and characterization of the cell.
2. The adhesion properties and functions of ECM Molecules in applications of tissue engineering.
3. The mechanism of drug delivery and Biomaterials Polymeric scaffolds maintain differentiated
function of the cell.
4. Clinical & Regulatory Aspects of Engineered Tissues of different cell types.
Course Content:
UNIT-I
Cell and Tissue Biology: Introduction to cell – biology and biochemistry. Tissue development and
organization. Stem cells (embryonic), Stem cells (adult). Introduction to cell adhesion, Adhesion
Receptors in Tissue Structures, Cell Adhesion to Biomaterials, Measurement of Cell Adhesion, Effect
of Biomaterial on Physiological Behavior. Introduction to cell migration, Characteristics of
Mammalian Cell Migration, Regulation of Cell Movement, Cell Migration Assays, Mathematical
Models for Cell Migration and Tissue Growth.
UNIT-II
Extracellular Matrix: Introduction, ECM and Functional Integration of Implanted Materials,
Basement Membranes and Focal Adhesions, Focal Adhesions as Signaling Complexes, ECM and
Skeletal Tissues, Sources of ECM for Tissue Engineering Applications, Properties of ECM , Mining
the ECM for Functional Motifs, Summary of Functions of ECM Molecules, Polymeric Materials and
their Surface Modification, Formation of Gradient Structures, Delivery of Growth Factors.
UNIT-III
Biomaterials & Drug Delivery Systems: Introduction to synthetic polymers, Biodegradable materials
vs permanent materials, Natural biopolymers and hydrogels, Mechanical properties of biomaterials,
Surface modification and characterization of polymers, Immune response to biomaterials, In vitro
assessment/biocompatibility/protein adsorption. Polymeric scaffolds for tissue engineering
applications. Drug delivery, Mechanisms of Drug Delivery, Protein-Drug Properties, Drug Delivery in
Tissue Engineering, Introduction to growth factors, Polymer scaffold delivery systems, Polymer
hydrogel delivery systems, Polymer microsphere technology.
UNIT-IV
Tissue Engineering Bioreactors - Design and Fabrication: Introduction, Most common Bioreactors
in Tissue Engineering, Cell Seeding in Bioreactors, Bioreactor Applications in Functional Tissues,
Design Considerations, Challenges in Bioreactor\ Technologies. Tissue Biomechanics, Scaffold
design and fabrication, Natural Polymers for Scaffold Fabrication, Synthetic Polymers for Scaffold
Fabrication, Scaffold Design Properties.
UNIT-V
Clinical & Regulatory Aspects of Engineered Tissues: Tissue Engineering of Skin, Bone Tissue
Engineering, Cartilage Tissue Engineering, Neuronal, Tissue Engineering, Cardiovascular Tissue
Engineering, Musculoskeletal Tissue Engineering, (tendon/ligament/muscle), Adipose Tissue
Engineering. Introduction, FDA Regulation, Regulation of Pharmaceutical / Medical Human Tissue
Products in Europe, Regulation of Pharmaceutical / Medical Human Tissue Products in Japan, Other
considerations Relevant to Engineered Tissues.
14
Text Books:
1 John P. Fisher, AG Mikos & Joseph D. Bronzino (2007) Tissue Engineering CRC Press.
2. Anthony Atala & P Lanza (2006) Methods of Tissue Engineering, Academic Press Elsevier
3. Drioli, Taylor & Francis (2005), Biocatalytic Membrane Reactor
Reference Books:
1. Channarayappa (2010) Cell Biology: Universities Press (India) Pvt Ltd.
2. Patrick CW, Mikos AG, McIntire LV (1998) Frontiers in Tissue Engineering, Pergamon Press.
3. Bernhard O Palsson, Sangeeta N Bhatia (2003) Tissue Engineering, Pearson Prentice Hall.
Max
marks
Evidence
collected
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
Class-room
open book
assignment
Twice( Average
of the two will
be computed)
10
Assignment
reports
Surprise quiz
Once
10
Quiz
answers
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
End of course
-
Questionnaire
Contributing
to Course
Outcomes
Indirect
Assessment
Methods
SEE
CIE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To whom When/ Where
(Frequency in
the course)
End of course
survey
Students
Students
Course Outcome: On completion of this course student will have improved ability:1: Identify and differentiate between various stages of tissue development & stem cells
2: Analyze the mechanism and organization of ECM and its functions
3: Apply knowledge of drug delivery mechanism & protein drug interactions
4: Integrate the knowledge of clinical and regulatory aspects on different engineered tissues in
pharmaceutical and medical human tissue products.
Mapping of course objectives with program outcomes
Course objective
1
2
3
4
a
X
X
X
X
b
X
X
c
d
X
X
X
X
Program Outcome
E
f
g
X
X
X
X
X
X
X
X
H
i
j
x
k
X
X
15
MEDICAL BIOTECHNOLOGY
Sub Code : BTPE12
CIE : 50 Marks
Credits : 3:0:0
SEE : 50 Marks
Prerequisite: Biochemistry
Course Coordinators: DR. Prabha M and Mr. Lokesh K N
Objectives of the course: The course will provide knowledge on:
1. The study the diseases causing from microbes and its detection, production of vaccines and
its types.
2. The scope and importance of ESC, Hemopoeitic Stem Cells and its Disorders.
3. The types of diagnosis and its significance in medical Biotechnology.
4. The current applications of biotechnology in Medicine for gene therapy to demonstrate high
standards for treatment of cancer, genetic and other diseases.
Course Content:
UNIT-I
Introduction & Stem Cells in Health Care: Introduction to Medial Biotechnology, scope and
applications, List of disease causing microbes and detection. Mammalian embryonic stem cells –
Definition, formation and properties of embryonic stem cells. Formation of differentiated cells from
stem cells. Differentiated progeny, epidermal stem cells in basal layer, differentiating epidermal cells,
synthesis of differentiating epidermal stem cells- a subset of basal cells, basal cell proliferation,
secretory cells in the epidermis.
UNIT-II
Hemopoietic Stem Cell Disorder: Classification and manifestations of Hemopoeitic stem cell
disorders, a plastic Hemopoietic stem cell disorders, clinical applications of colony stems,
complications of germ therapy, replacement therapy and bone marrow transplantation, immunological
principles, preservation and clinical use of blood and blood components.
UNIT-III
Vaccine Technology: Definition, history, classification of vaccines, preparation and standardization
of vaccines, cancer vaccine, birth control vaccines, AIDS vaccine, Pneumococcal vaccine, measles
vaccines, Future development and scope of vaccines.
UNIT-IV
Diagnostics: PCR bases diagnosis, Southern blot-based diagnosis DNA sequencing of representative
clones to detect mutation(s), PCR-SSCP to detect SNP analysis for known SNPs, PAGE:
Immunodiagnostics, DNA fingerprinting.
UNIT-V
Gene Therapy: General introduction, potential target diseases for gene therapy, gene transfer
methods, and their applications, clinical studies, pharmaceutical production and regulation.
Text Books:
1. Daan Crommelin, Robert D sindelar (1998) Pharmaceutical Biotechnology an Introduction for
pharmacists and pharmaceutical scientists, 2nd edition.
2. Willam irving, Time Boswell, Dlawar (1995) Instant notes, Medical Microbiology.
3. Sambamurthy (1994) Text book of Pharmaceutical Biotechnology, 3rd edn.
Reference Books:
1. Judit Pongracz, Mary Keen (2009) Medical Biotechnology, A Churchill Livingstone
publication.
2. Albert Sasson, (2006) Medical Biotechnology, Brookings Institution Press.
16
Indirect
Assessment
Methods
CIE
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To whom When/ Where
(Frequency in
the course)
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3&4
Class-room
open book
assignment
Once
10
Assignment
reports
1,2,3&4
Surprise quiz
Once
10
Quiz
answers
1,2,3&4
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
assessment
methods
End of course
survey
Students
Students
Course Outcome: On completion of this course student will have improved ability:1. To detect the disease causing microbes for diagnosis, production of vaccines in prevention and
treatment of diseases.
2. To understand the benefits and scope of Embryonic stem cells, Hemopoietic stem cells for
therapeutics and transplantation.
3. To apply the techniques such as PCR, Southern blot, PAGE, DNA finger printing for analysis
and diagnosis.
4. To analyze the gene transfer methods and pharmaceutical production for application of gene
therapy and treatment.
Mapping of course outcome with program outcomes
Program Outcome
Course
a
b
c
d
e
f
g
H
outcome
1
X
X
2
X
X
X
3
X
X
4
X
X
i
j
k
X
X
X
X
17
PRINCIPLES OF FOOD PROCESSING & PRESERVATION
Sub Code : BTOE01
Credits : 3:0:0
CIE : 50 Marks
SEE : 50 Marks
Prerequisite: None
Course Coordinator: Dr Bindu S
Objectives of the course:
1) This open elective course introduces the students of all branches of Engineering to the quality
attributes of food & factors affecting quality deterioration.
2) Students are introduced to the objectives & principles of food processing as relevant in the
food industry.
3) Provides an understanding of the principle, application, advantages & disadvantages of
conventional methods of food preservation like low temperature, high temperature,
dehydration etc.
4) Equips the students with knowledge on some of the restricted methods of food preservation
like membrane based separation & irradiation: its potential applications & safety issues.
Course Content:
UNIT-I
Basic consideration: Aim and objectives of preservation and processing of foods, characteristics of
food components, primary sources of microorganisms found in foods, deterioration of food quality,
causes of quality deterioration and spoilage of perishable foods, spoilage in canned foods
UNIT-II
Low temperature Preservation of foods: Chilling temperatures: Considerations relating to storage
of foods at chilling temperatures, low temperature applications in food preservation, controlled and
modified atmosphere storage of foods.
Freezing temperature: Preparation of foods for freezing, freezing process, slow and fast freezing of
foods and its consequences, storage stability of frozen foods, effect of freezing on microorganisms.
UNIT-III
High temperature preservation of foods: Basic concepts in thermal destruction of microorganismsD, Z, F, values, Heat resistance and thermophilisms in micro-organisms. Cooking, blanching,
pasteurization and sterilization of foods. Assessing adequacy of thermal processing of foods, general
process of canning of foods.
UNIT- IV
Preservation by Dehydration: Principles, technological aspects and applications of drying and
dehydration of foods. Principles, technological aspects and applications of evaporative concentration
processes, freeze concentration and membrane processes for food concentrations.
UNIT-V
Other techniques in preservation: Principles, technological aspects and applications of sugar and
salt, anti-microbial agents, non-ionizing and ionizing radiations in preservations of foods, Fermented
foods.
Text Books:
1. Norman N. Potter and Joseph H. Hotchkiss (2006) Food Science, 5th edition, CBS publishers and
Distributors
2. B. Sivasankar (2005) Food processing and preservation, Eastern economy edition, Prentice-Hall of
India Pvt. Ltd.
3. James M Jay (2005) Modern food microbiology, 4th edition, CBS publishers and Distributors.
18
Reference Books:
1. Shakuntala N. Manay and M. Shadaksharamurthy (2008) Foods: Facts and Principles, 3rd edition,
New Age International
2. Rick Parker (2001) Introduction to Food Science, 3rd edition, Cengage learning
3. Subbulakshmi G and Shobha A. Udupi (2006) Food Processing and Preservation, 1st edition, New
Age International
4. John M DeMan (1999) Principles of Food Chemistry, 3rd Edition, Springer – Verlag
Indirect
Assessment
Methods
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3&4
Assignment
Once
10
Assignment
reports
1&2
Once
10
Mini Project
Reports
3&4
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3 &4
End of course
-
Questionnaire
1,2,3 &4
Students
Mini Project
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where
whom
(Frequency in
the course)
Standard
examination
End of course
survey
Students
Outcome of the course:
1. List & identify the factors responsible for food spoilage including a description of the different
types of spoilages.
2. Compare and contrast the different low temperature food preservation methods & discuss their
principles.
3. Compare and contrast the different low temperature food preservation methods & discuss their
principles.
4. Discuss the applications of dehydration, membrane based separation & irradiation as methods of
food preservation.
19
BIOPROCESS CONTROL AND AUTOMATION LAB
Sub code
Credits
: BT 706L
: 0:0:1
CIE
SEE
: 50 Marks
: 50 Marks
Prerequisite: Bioprocess control & Automation
Course Coordinators: Mr.Gokulakrishnan M & Mr. Samrat K
Course Objectives:
1. To study the basic control methodologies.
2. To study the response of first order systems for different input changes.
3. To study the response of first order system in series for different input changes.
4. To study the transducer characteristics.
Course Content:
LABORATORY
List of EXPERIMENTS
1. Characteristics of Transducers (Temperature, Pressure, Flow)
2. Dynamics of First order –Thermometer- system for step input
3. Dynamics of First order -Liquid level system - for step input
4. Dynamics of first order systems -Liquid level- for impulse input
5. Dynamics of first order systems-thermometer- for pulse input
6. Dynamics of second order system ( Manometer)
7. Non-interacting systems
8. Interacting systems
9. Control of temperature in a bioprocess.
10. Control of pH in a bioprocess.
11. Control of Pressure in a bioprocess.
12. Control of Flow rates in a bioprocess.
13. Control of level
14. Study of Valve characteristics
Note: Any 12 experiments must be performed
Reference Books:
1. Bailey and Ollis (2010) Biochemical engineering fundamentals. McGraw Hill (2nd Ed)
2. George Stephanopoulous (2009) Chemical process control 1st ed., Prentice Hall of India.
20
Indirect
Assessment
Methods
CIE
SEE
Direct Assessment
Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/
Max
whom
Where
marks
(Frequency
in the
course)
Internal
assessment
tests
Evidence
collected
Contributing
to Course
Outcomes
Once
30
Blue books
1,2,3&4
Continuous
10
Attendance
1,2,3&4
Record
Continuous
10
Record
1,2,3&4
Standard
examination
End of
course
50
Answer scripts
1,2,3&4
End of
course
-
Questionnaire
----
Lab
Assessment
End of course
survey
Students
Students
Course Outcomes: On completion of this course student will have improved ability:1: Determine the control parameters
2: Predict the response of first order systems
3: Predict the response of first order system in series
4: Evaluate the transducer characteristics
Mapping of course outcome with program outcomes
Course
Outcomes
1
2
3
4
a
b
c
d
X
X
X
X
X
X
X
X
X
X
X
X
e
f
g
h
i
j
k
X
X
21
DOWNSTREAM PROCESS TECHNOLOGY & BIOSEPARATION
TECHNIQUES
Sub Code
: BT 707L
CIE
: 50 Marks
Credits
: 0:0:1
SEE
: 50 Marks
Prerequisite: Unit operations & Bioanalytical techniques
Course Coordinators: Mr. K N Lokesh and Mr. Samrat K
Course Objectives:
1. To impart the knowledge of working principles of the bioseparation and purification process
2. Practical knowledge of different methods of product isolation techniques.
3. Practical knowledge of product characterization/ estimation methods
Course Content:
LABORATORY
LIST OF EXPERIMENTS
1. Cell disruption techniques.
2. Solid-liquid separation methods: Sedimentation
3. Solid-liquid separation methods: Centrifugation, Filtration,
4. Product enrichment operations: Precipitation – (NH4)2 SO4 fractionation of a protein.
5. Product enrichment operations: Two – phase aqueous extraction.
6. Protein enrichment by altering the dielectric constant
7. Methods for Cell biomass estimation (Packed cell volume (PCV), Dry weight & wet weight of
biomass)
8. Separation of Amino acids / Carbohydrates by TLC.
9. SDS polyacrylamide gel electrophoreSsis
10.
DNA separation by Agarose Gel Electrophoresis
11.
Estimation of % of ethanol from fermented broth.
12.
Estimation of Citric acid from fermented broth.
13.
Separation of proteins by molecular sieving.
14.
Analysis of biomolecules by HPLC / GC.
Note: Any 12 experiments must be performed
Reference Books:
1. Upadhyay, Upadhyay, and Nath (2003) Biophysical Chemistry Principles and techniques,
Himalaya Publishing House.
2. Sivasankar B (2005) Bioseparations: Principles and Techniques, Eastern Economy Edition.
3. Okotore RO (2002) Basic Separation Techniques in Biochemistry, New age publishing Co.
22
Indirect
Assessm
ent
Methods
CIE
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/
Max
whom
Where
marks
(Frequency
in the
course)
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Once
30
Blue books
1,2,3&4
Lab
Assesment
Continuous
10
Attendance
1,2,3&4
Record
Continuous
10
Record
1,2,3&4
Standard
examination
End of
course
50
Answer
scripts
1,2,3&4
End of
course
-
Questionnaire
End of course
survey
Students
Students
Course Outcomes:
1: Choose appropriate unit operations for isolation and purification of biomolecules.
2: Identify appropriate qualitative and quantitative analysis methods depending upon the chemical
nature of analyte.
3: Enhance product output by selection of appropriate method of enrichment operation.
4: Enhance product quality by appropriate method of purification operation
Mapping of course outcome with program outcomes
Program Outcome
Course Outcomes
a
b
c
d
e
f
g
h
1
X
X
2
X
X
X
3
X
X
X
4
X
X
X
X
i
j
k
X
X
23
BIOETHICS & BIOSAFETY
Sub Code : BT801
Credits : 3:0:0
CIE : 50 Marks
SEE : 50 Marks
Prerequisite: None
Course Coordinator: Dr Bindu S
Course Objectives:
1. This course intends to instill awareness in Biotechnology (BT) undergraduates about sensitive
& ethical issues connected to BT.
2. Introduces them to the concept of Biosafety & its significance along with international as well
as national biosafety regulations as applied to transgenic research.
3. Case studies on transgenics & the ethical issues that crop up during the development of these
BT products.
4. Highlights the potential dangers of compromise on biosafety through case studies.
Course Content:
UNIT-I
Introducction to Bioethics and Biosaftey: Needs and definition of Bioethics, Ethical issues in
biotechnology. Application of bioethics, the expanding scope of ethics from biomedical practice to
biotechnology. Social and ethical issues in Biotechnology, Introduction to Biosaftey, needs and
definition of biosaftey, application and levels of biosaftey. Hazards related to Biosafety at work place,
development of biotech products. Examples and case studies.
UNIT-II
Ethical Issues: Ethical issues in genetically modified organisms (foods and crops); bioethics in
biodiversity and resource management. Animal cloning and human cloning and their ethical aspects.
Testing of drugs on human volunteers, organ transplantation and ethical issues; Xenotransplantion
and its ethical and social issues. Human Genome project.
UNIT-III
Biosafety regulations in transgenic research: National and international guidelines on rDNA
protocols. MOEF guidelines evolution, Good laboratory practice, Good manufacturing practice and
FDA regulations Pharmacopia standards Regulations for recombinant DNA research and
manufacturing process Public perception. National Institute of health (NIH) guideline, guidelines for
research in transgenic organisms. Experiments with microorganisms. Canadian Council on Animal
Care (CCAC) Guidelines on Transgenic Animals
UNIT-IV
Case studies in transgenic research: Case studies of GEAC approved projects. Drafting of
application to IBSC and procedure. BT cotton, golden Rice, genetic manipulation and ethical
considerations. Genetic studies in ethnic races. Recombinant DNA Advisory Committee Advisory
Committee (RDAC)
UNIT-V
Bioethics and biosafety in biotechnology: Ethical issues related to biotech products, Challenges to
Indian Biotech Industries and research institutes, Biological weapons CARTAGENA protocol
highlights. Examples of Monarch butterfly, HIV vaccine, Starlink maize.
Text Books:
1. Traynor PL (2000) Biosafety Management, Virginia polytechnic Institute Publication.
2. Sateesh M.K (2008) Bioethics & Biosafety, IK Publishers.
24
Reference Books:
1. Sassaon A. (1988) Biotechnologies and development. UNESCO Publications.
2. Sasson A. (1993) Biotechnologies in developing countries present and future, UNESCO
Publishers.
3. Rao MB (2003), WTO and International Trade, Vikas Publishing House Pvt. Ltd.
4. Erbisch F H and Maredia K M (2003), Intellectual Property Rights in Agricultural Biotechnology,
Orient Longman Ltd.
5. Cartagena Protocol on Biosafety, January 2000.
6. Dano MR (1994) Biological Warfare in the 21st century, by, Brassies London.
7. Safety Considerations for Biotechnology (1992 and latest publications), OECD Paris.
Indirect
Assessme
nt
Methods
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3&4
Assignment
Once
10
Assignment
reports
1&2
Once
10
Mini
Project
reports
3&4
End of course
(Answering 5
of 10
questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
1,2,3&4
Mini Project
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where
whom
(Frequency in
the course)
Students
Standard
examination
End of course
survey
Students
Course Outcomes:
1: List & interpret the social, legal & ethical issues connected with BT.
2: Recognize biosafety as relevant to Biotechnology & apply this knowledge in maintenance of
biosafety in research lab, field & industry.
3: Analyze & interpret biosafety regulations & their relevant applications in BT.
4: Identify the potential dangers in Biotechnology due to compromise on biosafety & apply
precautionary measures to avoid /overcome it.
Mapping of course outcome with program outcomes
Course
Outcomes
1
2
3
4
a
b
c
d
X
X
X
X
X
X
Program Outcome
e
f
g
h
X
X
X
X
X
X
X
i
j
k
25
PLANT DESIGN, ECONOMICS AND ENTREPRENEURSHIP
Sub Code
: BT802
CIE
: 50 Marks
Credits
: 4:0:0
SEE
: 50 Marks
Prerequisite: Process Equipment Design
Course Coordinators: Mrs. Bhavya S G & Dr. Chandraprabha M N
Objectives of the course: The course will provide:
1. To theoretically design of a project from conception to implementation including preliminary
feasibility study,
2. To prepare process flow diagram, process design, preconstruction cost estimate, equipment
sizing (design), selection of materials of construction and analysis of the project.
3. Ability to analyze the fundamentals of engineering economics and profitability analysis.
4. To analyze the principles of entrepreneurship with real time case studies.
Course Content:
UNIT- I
Process Design Development & General Design Considerations: Process design and development,
flow diagrams, marketability of the product, availability of technology, raw materials, equipment
design-specification and manufacturing/procurement, human resources, land and utilities, site
characteristics, waste disposal, government regulations and other legal restrictions, community factors
and other factors affecting investment and production costs.. Depreciation & interest and investment
cost: Time value of Money, Types of Interests, Nominal and effective interest rates, Continuous
interest, annuities, Perpetuities, Depreciation, Types of depreciation, Methods for estimating
depreciation. Numericals.
UNIT- II
Cost Estimation: Capital Investments: Fixed capital investments including land, building, equipment
and utilities, installation costs, working capital investment. Cost indius. Manufacturing costs: Direct
production costs (including raw materials, human resources, maintenance and repair, operating
supplies, power and other utilities, royalties, etc.,), fixed charges, Plant Overhead cost: Administration,
safety and other auxiliary services, payroll overhead, warehouse and storage facilities. Numericals.
UNIT- III
Profitability, Alternative Investments and Replacements: Profitability, basis for evaluating project
profitability, Methods for profitability evaluation, Alternative investments, Replacement analysis:
Replacement models, Break-Even analysis: Meaning and importance of Break-even point, Break-even
chart and analysis. Industrial process plant design case studies (scenarios): citric acid production plant,
food processing plant, soap production plant etc. Numericals.
UNIT- IV
Entrepreneurship: Meaning and importance, concepts of entrepreneurship, characteristics of
successful entrepreneurs, classification of entrepreneurs, myths of entrepreneurship, evolution of
entrepreneurship, development of entrepreneurship, stages in entrepreneurial process, role of
entrepreneurs in the economic development , entrepreneurship development in India, barriers for
entrepreneurship, profiles of successful entrepreneurs. Identification of business opportunities, market,
technical, financial and social feasibility studies.
Preparation Report: meaning of the project, project identification, project selection, project report,
need and significance of report, formulation and guidance by Planning Commission for project Report,
network analysis, errors of project report, project appraisal.
26
UNIT- V
Small scale Industries: Definition, characteristics, need, rationale objectives, scope for SSIs. Role of
SSI in economic development, advantages of SSI, Steps to start SSI, Govt. policies and support for
SSI (during 5 year plans), Impact of liberalization, globalization of SSI, Effect of WTO/GATT, IPR
and small Business enterprises, supporting agencies of Govt. for SSI – nature of support, objectives,
types of help, Brief definitions and description of ancillary and tiny industry. IPR and small business
enterprises.
Institutions supporting SSIs and SBEs – central and state level institutions
Women entrepreneurs: definition, environment, challenges, for women entrepreneurs, strategies for
development of women entrepreneurs self help groups, Institutions and women’s organization
supporting women entrepreneurs, profiles of successful women entrepreneurs.
Text Books:
1. Peters and Timmerhaus (1989) Plant Design and Economics for Chemical Engineers, 4th edn.,
McGraw Hill.
2. Rudd and Watson (1987) Strategy of Process Engineering, Wiley.
3. Poornima M C (2006) Entrepreneurship Development and Small Business Enterprises”, Pearson
education.
Reference Books:
1. Vasanth Desai (2007) Dynamics of Entrepreneurial Development & Management”, Himalaya
Publishing House.
2. Khanka SS (2004) Entrepreneurship Development, S Chand & Co.
3. Thomas W. Zimmer, Norman M. Scarborough.(2007), Essentials of Entrepreneurship and small
Business Management
Indirect
Assessmen
t Methods
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment
tests
Thrice(Average
of the best two
will be
computed)
30
Blue books
1,2,3&4
Class-room
open book
assignment
Twice( Average
of the two will
be computed)
10
Assignment
reports
2,3&4
Once
05
Case
solutions
3&4
Surprise
quiz
Once
05
Quiz
answers
3&4
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
----
Case
analysis
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where
whom
(Frequency in
the course)
End of course
survey
Students
Students
27
Outcome: Student learning outcomes will be: Upon successful completion of this course, the
students will be able to:
1: Acquire knowledge in the design of a chemical plant.
2: Conduct preliminary feasibility study of the plant design assigned.
3: Estimate the cost analysis involved in the design of a chemical plant.
4: Develop entrepreneurs with substantial knowledge in engineering concepts.
Mapping of course outcome with program outcomes
Program Outcome
Course
a
b
c
d
e
f
g
h
outcome
1
X
X
2
X
X
X
3
X
X
X
X
4
X
X
X
i
X
X
j
k
X
X
28
PROJECT WORK
Sub Code
Credits
: BT804
: 0:0:14
CIE
Project
50 marks
50 Marks
Prerequisite:
Course Coordinators: Project co-coordinator(s) / project work supervisor(s)
Course objectives:
1.Learn to define and design research project(s) in their area of interest
2.Provide a platform to students to interact with faculty, peer, scientists /industrialist to develop
projects.
3.Improve technical and professional skills
4.Learn to apply biotechnology concepts to real time projects.
Assessment and Evaluation vis-à-vis Course Outcomes:
When/ Where
(Frequency in
the course)
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Once
30
Oral
presentation
1,2,3&4
Punctuality
Throughout the
course
5
Attendance and
conduct during
project work
3
Project Work
report
Once
10
Project report
1,2,3&4
Middle of the
course
-
Feedback forms
To
whom
t
Asse
ssm
ent
Case analysis /
Literature survey
and presentation
skills
CIE
Direct Assessment
Methods
What
Students
Students feedback
Students
Course Outcome: On completion of this course student will have improved ability:1: Able to analyze complex data and draw scientific inferences or conclusion
2: Able to apply ethical, biosafety or socio-environmental concepts in their research work and at
professional career
3: To evaluate managerial and team work or independent work skills, which can pave way for
entrepreneurship
4: Able to apply research methodology for strategic formulation of research design.
Mapping of course outcome with program outcomes
Course outcome
1
2
3
4
a
X
X
X
b
X
X
X
c
d
X
X
Program Outcome
e
f
g
X
X
X
X
h
X
X
X
i
X
X
j
k
X
X
X
X
X
X
29
Sub Code
Credits
DRUG DESIGN AND DEVELOPMENT
: BTPE13
CIE
: 3:0:0
SEE
: 50 Marks
: 50 Marks
Prerequisite: Bioinformatics and Pharmaceutical Biotechnology
Course Coordinators: Krishna Murthy T P & Dr. Ravi Kumar
Course Objectives:
1. To give broad overview over classes of medicinal drugs and to understand the mechanism of
their action on molecular targets.
2. To illustrate the steps involved in the modern drug discovery process.
3. To know the concepts of Insilco drug design and molecular docking.
4. To apply the principles drug design in development of potential drug molecules for various
diseases.
Course Content:
UNIT-I
Introduction to Drug Discovery and Development:
History of drug discovery, design and development-Introduction to drugs, their action and discovery:
some desirable properties of leads and analogues, sources of leads and drugs, drugs from natural
sources, methods and routes of administration: the pharmaceutical phase-drug action: The
pharmacokinetic phase (ADME) and The pharmacodynamic phase-Classification of drugs- Drug
structure and solubility- Omics technologies and Bioinformatics in and drug discovery and
development.
UNIT: II
Molecular Drug Targets:
Enzymes as drug targets: Introduction to Enzymes, Structure, types, mode of action, regulation,
kinetics, inhibitors- Receptors as Drug Targets: Receptors, similarities and differences from enzymes,
receptor classification, types of ligands-Oligonucleotides as Drug Targets-Miscellaneous drug targets.
UNIT: III
The Modern Drug Discovery Process:
Traditional Medicine - Steps involved in Modern drug discovery- Finding a lead: Choosing a disease,
choosing a drug target, identifying a bioassay, finding a lead compound- Optimizing target interactionoptimizing access to the target-Getting the drug to market: Preclinical and clinical trials, patenting and
regulatory affairs , chemical and process development. Small molecule pharmaceutical drugs, large
molecule biopharmaceutical Drugs- Personalized Medicine.
UNIT-IV
Molecular Modeling and Insilico Drug Design:
Computer aided lead design-Determining Target Structure: Literature, X-Ray Crystallography, NMR
Spectroscopy, Molecular Modelling- Complementarity between a Target and Drug: Intermolecular
Forces, molecular shape, drug pharmacophore- Lingand Based drug design-Structure Based drug
design- Fragment Based Drug Design- Computer aided drug design- Molecular Docking procedures:
softwares for molecular docking, steps in molecular docking. Quantitative structure–activity
relationship (QSAR).
UNIT-V
Case Studies:
Antibacterial agents -Antiviral drugs used against DNA RNA viruses - Anti Cancer agents- Anti
Ulcer agents- Zinc enzymes as drug tagets: Carbonic anhydrase inhibitors and activators- Glycogen
synthase kinase inhibitors-Cyclooxygenase pathway and NSAID inhibitors.
30
Text Books:
1. Erland Stevens. Medicinal Chemistry: The Modern Drug Discovery Process. Prentice Hall; 1st
edition, 2012.
2. Graham L. Patrick. An Introduction to Medicinal Chemistry, 5th Edition, Oxford University
Press, USA. 2013.
3. Gareth Thomas. Medicinal Chemistry: An Introduction, Wiley-Blackwell, 2nd Edition
edition, 2007.
Reference Books:
1. Rick Ng , Drugs: From Discovery to Approval, Wiley-Blackwell; 3rd Edition, 2015
2. H. John Smith. Smith and Williams' introduction to the principles of drug design and action.
4th edition, CRC Press, 2006.
3. Povl Krogsgaard-Larsen, Kristian Strømgaard, Ulf Madsen. Textbook of Drug Design and
Discovery, 4th edition, CRC Press, 2010.
CIE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
What
To
When/ Where
whom
(Frequency in
the course)
Thrice(Average
Internal
of the best two
assessment tests
will be
computed)
Assignment
Indirect
Assessmen
t Methods
SEE
Surprise Test/
Quiz/ Mini
Project
Evidence
collected
Contributing
to Course
Outcomes
30
Blue books
1,2,3&4
Students
Assignment/
reports
Blue
books/Quiz
answers
Once
10
Once
10
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3&4
-
Feedback
forms
1,2,3&4 &
Delivery of
the course
Students
Standard
examination
Students feedback
Max
marks
End of course
1,2,3&4
1,2,3&4
Course Outcome:
1. Have knowledge on various types of drugs and their action respective molecular target.
2. To evaluate the principles of modern drug discovery and design.
3. To describe the various aspects Molecular modeling and Insilco drug design.
4. Integrate the knowledge acquired in drug discovery in development of potential drugs for
various diseases.
Mapping of course outcome with program outcomes
Course Outcomes
1
2
3
4
a
b
X
X
c
X
X
d
X
X
X
X
Program Outcome
e
f
g
X
X
X
h
i
j
k
X
X
31
Sub Code
Credits
NANO-BIOTECHNOLOGY
: BTPE14
CIE
: 3:0:0
SEE
: 50 Marks
: 50 Mark
Prerequisite:
Course Coordinator: Dr. Bindu S
Course Objectives: The course will
1. Provide an overview of the fundamental concepts of nanotechnology
2. Develop an understanding of bionano materials
3. Familiarize students with applications in the area of Biotechnology especially in health and
medical Biotechnology.
4. Provide an understanding of microfluidics & its relevance to nanotechnology
Course Content
UNIT-I
Introduction: A Brief History of the Super Small; Definition of Nano biotechnology. Discussions on
nanofabrication, Bottom-Up versus Top-Down, Nanolithography, Microelectronic fabrication,
Structure-property relationships in materials, biomolecule-surface interactions, Fabrication in Hard
Materials, Silicon and glass materials, Hydrogels/PDMS/other polymers and base materials for nanoand microfabricated devices, Valuing Nanobiotechnology.
UNIT-II
Nano Materials and their Characterization: Buckyballs, Nanotubes, Nanobiotechnology, materials
characterization techniques, scanning tunneling and atomic force microscopy, DNA microarrays,
quantum dots, and hybrid biological/inorganic devices. Scanning tunneling microscopy and Atomic
force microscopy. Nanobiomaterials: Function and application of DNA based nanostructures.
UNIT-III
Nanodiagnostics: Diagnostics and Sensors, Rapid Ex-Vivo Diagnostics, Nanosensors as Diagnostics,
Nanotherapeutics. Nanofabricated devices to separate and interrogate DNA, Interrogation of immune
and neuronal cell activities through micro-and nanotechnology based tools and devices.
UNIT-IV
Drug Discovery and Drug Delivery: Drug Discovery Using Nanocrystals, Drug Discovery Using
Resonance Light Scattering (RLS) technology, Benefits of Nano-Imaging Agents, Drug Delivery
using Nanobiosensors, Drug Delivery Applications, Bioavailability, Sustained and targeted release,
Nanorobots, Benefits of Nano-Drug Delivery, Drug Delivery, Health Risks, and Challenges,
Targeting, Drug Delivery Revenues, use of micro-needles and Nanoparticles for highly controlled
drug delivery.
UNIT-V
Microfluids: Laminar flow, Hagen – Pouiselle equation, basic fluid ideas, Special considerations of
flow in small channels, mixing, microvalves & micropumps, Approaches toward combining living
cells, microfluids and ‘the body’ on a chip, Chemotaxis, Case studies in Microfluidic devices.
BioMEMS: Introduction and Overview, Biosignal Transduction Mechanisms: Electromagnetic
Transducers Mechanical Transducers, Chemical Transducers, Optical Transducers –Sensig and
Actuating mechanisms (for all types). Ultimate Limits of Fabrication and Measurement, Recent
Developments in BioMEMS.
Text Books:
1. Stephen Lee and Lynn M Savage (1998) Biological molecules in Nanotechnology
32
2. Rosenthal, Sandra J and Wright, David W (2005) Nanobiotechnology Protocols, Humana Press.
Reference Books:
1. Richard Booker and Earl Boysen (2005) Nanotechnology, Wiely dreamtech edition
2. Chapman & Hall (2002) Nanobiotechnology – Basic Science & Emerging Technologies ,CRC
3. Gregory Timp (1998) Nanotechnology, (Ed) Spring.
4. Nanotechnology(2002)by Mark Ratner and Daniel Ratner
5. Ratner (2005) Pearson Education
6. Transducers and instrtumentation, D.V.S Murthy (2008), Prentice Hall of India
7. Principles of Applied Biomedical Instrumentation(1989), Ed. 3., Geddes (L.A) & Baker (L.E)
8. Biochip Technology, Jing Chung & Larry J. Kricka Harwood academic publishers, 2001
Ass
ess
me
CIE
Max
marks
Evidence
collected
Contributing
to Course
Outcomes
Internal
assessment tests
Thrice(Average
of the best two
will be computed)
30
Blue books
1,2,3&4
Assignment
Once
10
Assignment
reports
1&2
Mini Project
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
When/ Where
To
(Frequency in
What
whom
the course)
Standard
examination
End of course survey
Mini
Project
reports
Students
Students
Once
10
3&4
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
1,2,3&4
End of course
-
Questionnaire
1,2,3&4
Course Outcomes: on completion of this course student will have the ability to:1: Apply the fundamental concepts of nanotechnology in biotechnology.
2: Identify appropriate methods to synthesize and characterize nano materials.
3: Apply nanotechnology in diagnostics and therapeutics.
4: Improve drug discovery and delivery methods by applying microfluidics, nanorobotics and nano
biosensors.
Mapping of course outcome with program outcomes
Program Outcome
Course Outcomes
a
b
c
d
e
f
g
h
1
X
2
X
X
X
X
3
X
X
X
X
4
X
X
X
i
j
k
33
OPERATION RESEARCH & MANAGEMENT
Sub Code : BTPE15
CIE : 50 Marks
Credits : 3:0:0
SEE : 50 Marks
Prerequisite: Engineering mathematics
Course Coordinators: Mr. Samrat K.
Objectives of the course:
1. Understand the major capabilities and limitations of deterministic operations research modelling as
applied to problems in industry or government.
2. Be able to recognize, formulate and, using prepared computer packages, solve allocation models of
static or dynamic type.
3. Understand the reasons why the applicable algorithms work, and the effects on the computed
solutions of variations in the data or in the assumptions underlying the models.
4. Be able to communicate the results of the modelling process to users who are not operations
research specialists.
Course Content:
UNIT-I
Introduction: Operations research model, solving the operation research model, Queuing and
simulation models, Art of modelling, Phases of operation research study.
Linear Programming: Two variable L-P model, Graphical linear programming solution, Analysis of
selected linear programming models.
UNIT-II
The Simplex Method: Linear Programming solution space, Graphical to algebraic solution. The
simplex method. Artificial starting solution, Special cases in simplex method applications.
UNIT-III
Transportation Model and Iotas Variants: Definition of transportation model. Non-traditional
transportation models, Transportation algorithms, assignment model.
UNIT-IV
Network Models: Network definitions, Minimal spanning tree algorithm, CPM and PERT.
UNIT-V
Introduction to engineering management: Engineering and Management, Historical Development
of Engineering Management.
Functions of Technology Management: Planning and Forecasting, Decision Making, Organizing,
Motivating and Leading Technical People, Controlling.
Managing Projects: Project Planning and Acquisition, Project Organization, Leadership and Control.
Text Books:
1. Hamdy H Taha (2002): Operation Research – An Introduction, 7e, Person Education/PHI2. Babcock & Morse (2004): Managing Engineering and Technology, Person Education,
Reference Books:
1. Hellriegel, Jackson, Slocum (2003) Management – A competency based approach, Thomson South
Western,
2. Koontz Weir rich (1988) Management, McGraw Hill,
3. Wayne L Winston (2003) Operations Research – Applications and Algorithms, Thomson Learning
34
Ass
ess
me
CIE
Max
marks
Evidence
collected
Internal
assessment
tests
Thrice(Average of
the best two will
be computed)
Blue books
Class-room
open book
assignment
Twice( Average of
the two will be
computed)
Assignment
reports
Once
Case
solutions
Surprise quiz
Once
Quiz
answers
Standard
examination
End of course
(Answering 5 of
10 questions)
100
Answer
scripts
End of course
-
Questionnaire
Case analysis
SEE
Direct Assessment Methods
Assessment and Evaluation vis-à-vis Course Outcomes:
When/ Where
To
What
(Frequency in the
whom
course)
End of course
survey
Students
Students
Contributing
to Course
Outcomes
Course Outcome:
1: To demonstrate the skill of applying basic techniques to solve the proposed model
2: To apply mathematical software to solve the linear programming and integer programming models.
3: To build and solve Transportation Models and Assignment Models
4: To design new simple models, like: CPM, PERT to improve decision making processes
Mapping of course outcomes with program outcomes
Course outcome
1
2
3
4
a
X
X
X
b
X
X
X
c
d
Program Outcome
e
f
g
X
h
i
X
j
k
X
X
X
X
X
X
35