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O'Callaghan, J.P. and Holtzman, S.G.: Quantification of the analgesic activity of narcotic
antagonists by a modified hot-plate procedure. J. Pharmacol. Exp. Ther. l92: 497-505,
l975.
O'Callaghan, J.P. and Holtzman, S.G.: Prenatal administration of morphine to the rat:
Tolerance to the analgesic effect of morphine in the offspring. J. Pharmacol. Exp. Ther.
l97: 533-544, l976.
O'Callaghan, J.P. and Holtzman, S.G.: Prenatal Administration of levorphanol or
dextrorphan to the rat: Analgesic effect of morphine in the offspring. J. Pharmacol. Exp.
Ther. 200: 255-262, l977.
O'Callaghan, J.P., Williams, N. and Clouet, D.H.: The effect of morphine on the
endogenous phosphorylation of synaptic plasma membrane proteins of rat striatum. J.
Pharmacol. Exp. Ther. 208: 96-l05, l979.
O'Callaghan, J.P., Chess, Q., McKimmey, C., and Clouet, D.H.: The Effects of opiates
on the levels of cyclic 3'5'- guanosine monophosphate in discrete areas of the rat central
nervous system. J. Pharmacol. Exp. Ther. 2l0: 36l-367, l979.
O'Callaghan, J.P., Juskevich, J.C. and Lovenberg, W.: Stimulation of synaptic membrane
phosphorylation by a calcium and calmodulin independent heat stable cytosol factor.
Biochem. Biophys. Res. Comm. 95: 82-89, l980.
Kuhn, D.M., O'Callaghan, J.P. and Lovenberg, W.: The role of calmodulin in the
activation of tryptophan hydroxylase by phosphorylating conditions. Ann. N.Y. Acad.
Sci. 356: 399, 1980.
O'Callaghan, J.P., Dunn, L.A. and Lovenberg, W.: Calmodulin-mediated
phosphorylation of synaptosomal cytosolic proteins. Annals. N.Y. Acad. Sci. 356: 4l742l, l980.
Kuhn, D.M., O'Callaghan, J.P., Juskevich, J. and Lovenberg, W.: Activation of brain
tryptophan hydroxylase by ATP- Mg++: Dependence on calmodulin. Proc. Natl. Acad.
Sci. USA 77: 4688-469l, l980.
O'Callaghan, J.P., Dunn, L.A. and Lovenberg, W.: Calcium-regulated phosphorylation in
synaptosomal cytosol: Dependence on calmodulin. Proc. Natl. Acad. Sci. USA. 77: 58l258l6, l980.
O'Callaghan, J.P., Juskevich, J.C. and Lovenberg, W.: The effects of morphine on
calcium-regulated phosphorylation of synaptosomal cytosolic proteins from rat striatum.
J. Pharmacol. Exp. Ther. 220: 696-702, l982.
O'Callaghan, J.P., Miller, D.B. and Reiter, L.W.: Acute postnatal exposure to triethyltin
in the rat: Effects on specific protein composition of subcellular fractions from
developing and adult brain. J. Pharmacol. Exp. Ther. 224: 466-472, 1983.
Patton, S.E., O'Callaghan, J.P., Miller, D.B. and Abou-Donia, M.B.: The effect of oral
administration of tri-o-cresyl phosphate on in vitro phosphorylation of membrane and
cytosolic proteins from chicken brain. J. Neurochem. 41: 897-901, 1983.
O'Callaghan, J.P. and Miller, D.B.: Nervous-system specific proteins as biochemical
indicators of neurotoxicity. Trends in Pharmacological Sciences. 4: 388-390, 1983.
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O'Callaghan, J.P., Lavin, K.L., Chess, Q. and Clouet, D.H.: A method for dissection of
discrete regions of rat brain following microwave irradiation. Brain Res. Bull. 11: 31-42,
1983.
Cook, L.L., Heath, S.M. and O'Callaghan, J.P.: Distribution of tin in brain subcellular
fractions following the administration of trimethyltin and triethyltin to the rat. Toxicol.
Appl. Pharmacol. 73: 564-568, 1984.
O'Callaghan, J.P. and Miller, D.B.: Neuron-specific phosphoproteins as biochemical
indicators of neurotoxicity: effects of acute administration of trimethyltin to the adult rat.
J. Pharmacol. Exp. Ther. 231: 736-743, 1984.
Miller, D.B. and O'Callaghan, J.P.: Biochemical, functional and morphological
indicators of neurotoxicity: effects of acute administration of trimethyltin to the
developing rat. J. Pharmacol. Exp. Ther. 231: 744-751, 1984.
Patton, S.E., Lapadula, D.M., O'Callaghan, J.P., Miller, D.B. and Abou-Donia, M.B.:
Changes in in vitro brain and spinal cord protein phosphorylation after a single oral
administration of tri-o-cresyl phosphate to hens. J. Neurochem. 45: 1567-1577, 1985.
O'Callaghan, J.P. and Miller, D.B.: Cerebellar hypoplasia in the Gunn rat is associated
with quantitative changes in neurotypic and gliotypic proteins. J. Pharmacol. Exp. Ther.
234: 522-533, 1985.
O'Callaghan, J.P. and Miller, D.B.: Diethyldithiocarbamate increases distribution of
cadmium to brain but prevents cadmium-induced neurotoxicity. Brain Res. 370: 354-358,
1986.
Brock, T.O. and O'Callaghan, J.P.: Quantitative changes in the synaptic vesicle proteins,
synapsin I and p38, and the astrocyte specific protein, GFAP, are associated with
chemical-induced injury to the rat central nervous system. J. Neurosci. 7: 931- 942,
1987.
Miller, D.B., Blackman, C.F. and O'Callaghan, J.P.: An increase in glial fibrillary acidic
protein follows brain hyperthermia in rats. Brain Res. 415: 371-374, 1987.
O'Callaghan, J.P.: Cell-specific proteins as indicators of metal neurotoxicity. Fundam.
Appl. Toxicol. 9: 613-615, 1987.
O'Callaghan, J.P. and Miller, D.B.: Acute exposure of the neonatal rat to triethyltin
results in persistent changes in neurotypic and gliotypic proteins. J. Pharmacol. Exp.
Ther. 244: 368-378, 1988.
Balaban, C.D., O'Callaghan, J.P. and Billingsley, M.L.: Trimethyl-tin-induced neuronal
damage in the rat brain: Comparative studies using silver degeneration stains,
immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins.
Neuroscience 26: 337-361, 1988.
O'Callaghan, J.P. and Miller, D.B.: Acute exposure of the neonatal rat to tributyltin
results in decreases in biochemical indicators of synaptogenesis and myelinogenesis. J.
Pharmacol. Exp. Ther. 246: 394-402, 1988.
Reinhard, J.F., Jr., Miller, D.B. and O'Callaghan, J.P.: The neurotoxin MPTP (1-methyl4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases
dopamine levels of the mouse striatum: Evidence for glial response to injury. Neurosci.
Lett. 95: 246-251, 1988.
O'Callaghan, J.P., Niedzwiecki, D.M. and Means, J.C.: Variations in the neurotoxic
potency of trimethyltin. Brain Res. Bull. 22: 637-642, 1989.
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O'Callaghan, J.P., Brinton, R.E. and McEwen, B.S.: Glucocorticoids regulate the
concentration of glial fibrillary acidic protein throughout the brain. Brain Res. 494: 159161, 1989.
Wainfan, E., Dizik, M. and O'Callaghan, J.P.: Prolonged survival of female AKR mice
fed diets supplemented with methionine and choline. Carcinogenesis 11: 361-363, 1990.
O'Callaghan, J.P., Miller, D.B. and Reinhard, J.F., Jr.: Characterization of the origins of
astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl1,2,3,6-tetrahydro-pyridine. Brain Res. 521: 73-80, 1990.
O'Callaghan, J.P., Miller, D.B. and Reinhard, J.F., Jr.: MPTP-induced damage of striatal
dopaminergic fibers attenuates subsequent astrocyte response to MPTP. Neurosci.
Lett. 117: 228-233, 1990.
Burdette, L.J. and O'Callaghan, J.P.: Ca2+/calmodulin-dependent protein
phosphorylation is not altered by amygdaloid kindling. Brain Res. Bull. 26: 455-459,
1991.
O'Callaghan, J.P. and Miller, D.B.: The concentration of glial fibrillary acidic protein
increases with age in the mouse and rat brain. Neurobiol. Aging 12: 171-174, 1991.
Gordon, C.J., Watkinson, W.P., O'Callaghan, J.P. and Miller, D.B.: Effects of 3,4methylenedioxymethamphetamine on autonomic thermo-regulatory responses of the rat.
Pharmacol. Biochem. Behav. 38: 339-344, 1991.
Frankfurt, M., O'Callaghan, J. and Beaudet, A.: 5,7-Dihydroxytryp-tamine injections
increase glial fibrillary acidic protein in the hypothalamus of adult rats. Brain Res. 549:
138-140, 1991.
Miller, D.B., Reinhard, J.F., Jr., Daniels, A.J. and O'Callaghan, J.P.:
Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) and of in vitro 1-methyl-4-phenylpyridinium (MPP+).
J. Neurochem. 57: 541-549, 1991.
O'Callaghan, J.P., Brinton, R.E. and McEwen, B.S.: Glucocorticoids regulate the
synthesis of glial fibrillary acidic protein in intact and adrenalectomized rats but do not
affect its expression following brain injury. J. Neurochem. 57: 860-869, 1991.
O'Callaghan, J.P.: Quantification of glial fibrillary acidic protein: Comparison of slotimmunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13: 275281, 1991.
Reinhard, J.F., Jr. and O'Callaghan, J.P.: Measurement of tyrosine hydroxylase
apoenzyme protein by enzyme-linked immunosorbent assay (ELISA): Effects of 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase
activity and content. Anal. Biochem. 196: 296-301, 1991.
Haykal-Coates, N., O'Callaghan, J.P., Reinhard, J.F., Jr. and Jensen, K.F.: Parygyline
and gamma butyrolactone enhance tyrosine hydroxylase immunostaining of nigrostriatal
axons. Brain Res. 556: 353-357, 1991.
O'Callaghan, J.P.: Assessment of neurotoxicity: Use of glial fibrillary acidic protein as a
biomarker. Biomed. Environ. Sci. 4: 197-206, 1991.
Miller, D.B., Luebke, R.W., Reinhard, J.F., Jr. and O'Callaghan, J.P.: The neurotoxicant
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) alters immune function when
given in combination with diethyldithiocarbamate (DDC). Ann. NY Acad. Sci. 648: 309311, 1992.
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Sparber, S.B., O'Callaghan, J.P. and Berra, B.: Ganglioside treatment partially
counteracts neurotoxic effects of trimethyltin but may itself cause neurotoxicity in rats:
Experimental results and a critical review. Neurotoxicology 13: 679-700, 1992.
Genter, M.B., Llorens, J., O'Callaghan, J.P., Peele, D.B., Morgan, K.T. and Crofton,
K.M.: Olfactory toxicity of β,β'-iminodipropionitrile (IDPN) in the rat. J. Pharmacol.
Exp. Ther. 263: 1432-1439, 1992.
O'Callaghan, J.P. and Seidler, F.J.: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyrine (MPTP)induced astrogliosis does not require activation of ornithine decarboxylase. Neurosci.
Lett. 148: 105-108, 1992.
Goodlett, C.R., Leo, J.T., O'Callaghan, J.P., Mahoney, J.C. and West, J.R.: Transient
cortical astrogliosis induced by alcohol exposure during the neonatal brain growth spurt
in rats. Dev. Brain Res. 72: 85-97, 1993.
Llorens, J., Crofton, K.M. and O'Callaghan, J.P.: Administration of 3,3'iminodipropionitrile to the rat results in region-dependent damage to the CNS at levels
above the brain stem. J. Pharmacol. Exp. Ther. 265: 1492-1498, 1993.
Day, J.R., Laping, N.J., Brown, S.A., Lampert-Etchells, M., Brown, S.A., O'Callaghan,
J.P., McNeill, T.H. and Finch, C.E.: Gonadal steroids regulate the expression of GFAP
in the adult male rat hippocampus. Neuroscience 55: 435-443, 1993.
Miller, D.B. and O'Callaghan, J.P.: The interactions of MK-801 with the amphetamine
analogues- d-methamphetamine, d-3,4-methylene-dioxymethamphetamine or dfenfluramine: neural damage and neural protection. Ann. N.Y. Acad. Sci. 679: 321-324,
1993.
O'Callaghan, J.P.: A potential role for altered protein phosphorylation in the mediation
of developmental neurotoxicity. Neurotoxicology 15: 29-40, 1994.
Deamer, N.J., O'Callaghan, J.P. and Genter, M.B.: Olfactory toxicity resulting from
dermal application of 2,6-dichlorobenzo-nitrile (dichlobenil) in the C57Bl mouse.
Neurotoxicology 15: 287-293, 1994.
Goldey, E.S., O'Callaghan, J.P. Stanton, M.E., Barone, S. and Crofton, K.M.:
Developmental neurotoxicity: Evaluation of testing procedures with
methylazoxymethanol and methylmercury. Fund. Appl. Toxicol. 23: 447-464, 1994.
McMillian, M.K., Thai, L., Hong, J.-S., O'Callaghan, J.P., and Pennypacker, K.R.: Brain
injury in a dish: a model for reactive gliosis. Trends in Neuroscience 17: 138-142, 1994.
O'Callaghan, J.P. and Miller, D.B.: Neurotoxicity profiles of substituted amphetamines
in the C57/Bl6J mouse. J. Pharmacol. Exp. Ther. 270: 741-751, 1994.
Miller, D.B. and O'Callaghan, J.P.: Environment-, drug- and stress- induced alterations
in body temperature affect the neurotoxicity of substituted amphetamines in the C57/Bl6J
mouse. J. Pharmacol. Exp. Ther. 270: 752-760, 1994.
Laping, N.J., Teter, B., Anderson, C.P., Osterburg, H.H., O'Callaghan, J.P., Johnson, S.A.
and Finch, C.E.: Age-related increases in glial fibrillary acidic protein do not show
proportionate changes in transcription rates or DNA methylation in cerebral cortex and
hippocampus of male rats. J. Neurosci. Res. 39:710-717, 1994.
Rozovsky, I., Laping, N.J., Krohn, K., Teter, B., O'Callaghan, J.P. and Finch, C.E.:
Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat
astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron
interactions. Endocrinol. 136: 2066-2073, 1995.
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Martin, P.M. and O'Callaghan, J.P.: A direct comparison of GFAP
immunocytochemistry and GFAP concentration in various regions of ethanol-fixed rat
and mouse brain. J. Neurosci. Methods 58: 181-192, 1995.
Fix, A.S., Wrightman, K.A. and O'Callaghan, J.P.: Reactive gliosis induced by MK-801
in the rat posterior cingulate/retrosplenial cortex: GFAP evaluation by sandwich ELISA
and Immunocytochemistry. Neurotoxicology 16: 229-238, 1995.
Gordon, C.J. and O'Callaghan, J.P.: Trimethyltin-induced neuropathy in the rat:
interaction with thermoregulation. Neurotoxicology 16: 319-326, 1995.
Johnson, K.B., Moy, S.S. Knapp, D.J., Criswell, H.E., O'Callaghan, J.P., Mueller, R.A.,
Breese, G.R.: NMDA antagonists MK-801 and CGS-19755 dissociate behavioral and
striatal c-fos sensitization to a D1-dopamine agonist in neonatal 6-hydroxydopaminelesioned rats. J. Pharmacol. Exp. Ther. (submitted).
Guilarte, T.R., Kuhlmann, A.C., O'Callaghan, J.P. and Miceli, R.C.: Enhanced
expression of peripheral benzodiazepine receptors in trimethylin-exposed rat brain: A
biomarker of neurotoxicity. Neurotoxicology 16: 441-450, 1995.
McCann, M.J., O'Callaghan, J.P., Martin, P.M., Bertram, T. and Streit, W.J.: Differential
activation of microglia and astrocytes following trimethyl-tin-induced neurodegeneration.
Neuroscience 72: 273-281,1996.
Appel, N.M., Rappoport, S.I. and O’Callaghan, J.P.: Sequelae of parenteral domoic acid
administration in rats: comparison of effects on different anatomical markers in brain.
Synapse 25: 350-358, 1997.
Appel, N.M., Rappoport, S.I., O’Callaghan, J.P., Bell, J.M. and Freed, L.M.: Sequelae of
parenteral domoic acid administration in rats: comparison of effects on different
metabolic markers in brain. Brain Res. 754: 55-64, 1997.
O’Callaghan, J.P. and Miller, D.B. RE: Brain serotonin neurotoxicity and primary
pulmonary hypertension from fenfluramine and dexfenfluramine. JAMA 278: 2141,
1997.
Yokel, R.A. and O’Callaghan, J.P.: An aluminum-induced increase in GFAP is
attenuated by some chelators. Neurotoxicology and Teratology 20: 55-60, 1998.
Day, J.R., Frank, A.T., O’Callaghan, J.P. Jones, B.C. and Anderson, J.E: The effect of
age and testosterone on the expression of GFAP in the rat cerebellum. Exp. Neurol. 151:
343-346, 1998.
Buxbaum, J.D., Thinakaran, G., Koliatsos, V., O’Callaghan, J.P., Slunt, H.H., Price, D.L.
and Sisodia, S.S.: Alzheimer amyloid protein precursor in the rat hippocampus:
Transport and processing through the perforant path. J. Neurosci. 18: 9629-9637, 1998.
Dugar, A., Patanow, C., O’Callaghan, J.P. and Lakoski, J.M.: Immunohistochemical
localization and quantification of GFAP and SNAP-25 in the aging hippocampus
following administration of 5,7-dihydroxytryptamine. Neuroscience 85: 123-133, 1998.
Miller, D.B., Ali, S.F., O’Callaghan, J.P., and Laws, S.C.: The impact of gender and
estrogen on striatal dopaminergic neurotoxicity. Ann. NY Acad. Sci. 844: 153-165,
1998.
O’Callaghan, J.P., Martin, P.M. and Mass, M.J.: The MAP kinase cascade is activated
prior to the induction of gliosis in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) model of dopaminergic neurotoxicity. Ann. NY Acad. Sci. 844: 40-49, 1998.
O’Callaghan, J.P.: Astrocytes: Key players in mediation or modulation of neurotoxic
responses? Neurotoxicol. 19: 35-36, 1998.
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Fienberg, A.A., Hiroi, N., Mermelstein, P.G., Song, W.-J., Snyder, G.L. Nishi, A.,
Cheramy, A., O’Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N.,
Cooper, D.C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.J., Hyman, S.E., Surmeier,
D.J., Girault, J.-A., Nestler, E.J. and Greengard, P.: DARPP-32, regulator of the efficacy
of dopaminergic neurotransmission. Science (Wash., D.C.) 281:838-842, 1998.
Day, J.R., Frank, A.T., O’Callaghan, J.P. and DeHart, B.W.: The effects of microgravity
and bone morphogenetic protein II on GFAP in rat brain. J. Appl. Physiol. 85: 716-722,
1998.
Schmidt, G.R., Hossner, K.L., Yemm, R.S., Gould, B.H. and O’Callaghan, J.P.: An
enzyme-linked immunosorbant assay (ELISA) for glial fibrillary acidic protein (GFAP)
as an indicator of the presence of brain or spinal cord in meat. J. Food Protect. 62: 394397, 1999.
O’Callaghan, J.P., Imai, H., Miller, D.B. and Minter, A.: Quantitative immunoblots of
proteins resolved from tissue homogenates: underestimation of specific protein
concentration and of treatment effects. Anal. Biochem. 274: 18-26, 1999.
Mani, S.K., Fienberg, A.A., O’Callaghan, J.P., Snyder, G.L., Allen, P.B., Mitchell, A.J.,
Bibb, J., Greengard, P. and O’Malley, B.W.: The neuronal phosphoprotein DARPP-32 is
required for dopamine and progesterone-facilitated sexual behavior in female rodents.
Science (Wash., D.C.) 287: 1053-1056, 2000.
Kalia, M., O’Callaghan, J.P. and Miller, D.B.: Comparative study of fluoxetine,
sibutramine, sertraline and dexfenfluramine on the morphology of serotonergic nerve
terminals using serotonin immunohistochemistry. Brain Res. 858: 92-105, 2000.
Pennypacker, K.R., Yang, X., Gordon, M..N., Benkovic, S., Miller, D. and O’Callaghan,
J.P.: Long-term induction of FRA-2 after methamphetamine-,
methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and
trimethyltin-induced brain injury. Neuroscience 101:913-919, 2000.
Lam, H.R., Ladefoged, O., Østergard, G., and O’Callaghan, J.P.: Inhalation exposure to
white spirit causes region-dependent alterations in the levels of glial fibrillary acidic
protein. Neurotox. Teratol. 22:725-731, 2000.
Pennypacker, K.R., Eidizedeh, S., Kassed, C.A., O’Callaghan, J.P., Sanberg, R., and
Willing, A.E.: Expression of FRA-2 in rat hippocampus after middle cerebral arterial
occlusion. Neurosci. Let. 289:1-4, 2000.
Pennypacker, K.R., Kassed, C.A., Eidizadeh, S. and O’Callaghan, J.P.: Prolonged
induction of transcription factors in brain injury. Acta Neurobiologiae Experimentalis 60:
515-530, 2000.
Bibb, J.A., Nishi, A., O’Callaghan, J.P., Snyder, G. Horiuchi, A., Lan, M., Ule, J.,
Pelech, S.L., Meijer, L., Saito, T., Hisanaga, S., Czernik, A.J., Nairn, A.C. and
Greengard, P.: Phosphorylation of protein phosphatase inhibitor-1 by CDK5. J. Biol.
Chem. 276:14490-14497, 2001.
Ross, G.W., Sharp, D.S., O’Callaghan, J.P., Petrovitch, H., Miller, D.B., Nelson, J.,
Launer, L.J. and White, L.R.: Glial fibrillary acidic protein levels at death in the
neocortex of elderly Japanese-American men with Alzheimer’s disease. Acta Neurol.
Scand. 107:318-323, 2003.
Johnson, E.A., O’Callaghan, J.P. and Miller, D.B.: Chronic treatment with
supraphysiological levels of corticosterone enhances d-MDMA-induced dopaminergic
neurotoxicity in the C57Bl/6J female mouse. Brain Res. 933: 130-138, 2002.
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Johnson, E.A., Shvedova, A.A., Kisin, E., O’Callaghan, J.P., Kommineni, C., Miller,
D.B.: d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and
hepatotoxicity. Brain Res. 933: 150-163, 2002.
Little, A.R. and O’Callaghan, J.P.:Astrogliosis in the adult and developing CNS: Is there
a role for cytokines? Neurotoxicology 22: 607-618, 2001.
Bowyer, J.F., Holson, R.R., Miller, D.B. and O’Callaghan, J.P.: Phenobarbital and
dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms
that are independent of thermoregulation. Brain Res. 919: 179-183, 2001.
Schmidt, G.R., Yemm, R.S., Childs, K.D., O’Callaghan, J.P. and Hossner, K.L.: The
presence of central nervous system tissue on beef carcasses and in comminuted beef.
J. Food Protection 64: 2047-2052, 2001.
Sriram, K., Benkovic, S.A., Miller, D.B. and O’Callaghan, J.P.: Leptin-deficient (ob/ob)
condition exacerbates toxicant-induced neurodegeneration. Neuroscience 115: 13351346, 2002.
Gordon, M.N., Holcomb, L.A., Jantzen, P., DiCarlo, G., Wilcock, D., Boyett, K.W.,
Connor, K., Melanchrino, J., O’Callaghan, J.P. and Morgan, D.: Time course of the
development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.
Exp. Neurol. 173: 183-195, 2002.
Little, A.R., Benkovic, S.A., Miller, D.B. and O’Callaghan, J.P.: Chemically-induced
neuronal damage and gliosis: Enhanced expression of the proinflammatory cytokine,
MCP-1, without a corresponding increase in proinflammatory cytokines. Neuroscience
115: 307-320, 2002.
Sriram, K., Matheson, J.M., Benkovic, S.A., Miller, D.B., Luster, M.I. and O’Callaghan,
J.P.: Mice deficient in the TNF-α receptors are protected against dopaminergic
neurotoxicty: implications for Parkinson’s disease. FASEB J. 16: 1474-1476, 2002
Rozovsky, I., Hoving, S., Anderson, C.P., O’Callaghan, J. and Finch, C.E.: Equine
estrogens induce apolipoprotein E and GFAP in mice glial cultures. Neurosci. Lett. 323:
191-194, 2002.
Miller, D.B. and O’Callaghan, J.P.: Elevated environmental temperature and
methamphetamine neurotoxicity. Environmental Research 92: 48-53, 2003.
MacPhail, R.C., O'Callaghan, J.P. and Cohn, J.: Acquisition, steady-state performance
and the effects of trimethyltin on the operant behavior and hippocamapl GFAP of LongEvans and Fischer-344 rats. Neurotoxicol. Teratol. 25: 481-490, 2003.
Luellen, B.A., Miller, D.B., Chisnell, A.C., Murphy, D.L., O’Callaghan, J.P. and
Andrews, A.M.: Neuronal and Astroglial Responses to the Serotonin and
Norepinephrine Neurotoxin: 2’-NH2-MPTP. J. Pharmacol. Exp. Ther. 307: 923-931,
2003.
Bowyer, J.F., Harris, A.J., Delongchamp, R.R., Jakab, R., Miller, D.B., Little, A.R. and
O’Callaghan, J.P.: Selective changes in gene expression in cortical regions sensitive to
amphetamine during the neurodegenerative process. Neurotoxicology 25: 555-572, 2004.
Johnson, E.A., O’Callaghan, J.P. and Miller, D.B.: Brain concentrations of d-MDMA are
increased after stress. Psychopharmacology 173: 278-286, 2004.
Benkovic, S.A., O’Callaghan, J.P. and Miller, D.B.: Sensitive indicators of injury reveal
hippocampal damage in C57BL/6J mice treated with kainic acid in the absence of tonicclonic seizures. Brain Res. 1024: 59-76, 2004.
Sriram, K., Benkovic, S.A., Hebert, M.A., Miller, D.B. and O’Callaghan, J.P.:
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Activation of the gp130-JAK/STAT3 pathway in astrocytes precedes the induction of
GFAP in the MPTP model of dopaminergic neurodegeneration: Key signaling pathway
for astrogliosis? J.Biol. Chem. 279: 19936-19947, 2004.
O’Callaghan, J.P. and Sriram, K.: Focused microwave irradiation of the brain preserves
in vivo protein phosphorylation: Comparison with other methods of sacrifice and analysis
of multiple phosphoproteins. J. Neurosci. Methods 135: 159-168, 2004
De Groot, D., Pelgrim, M., Pakkenberg, B., Kaufmann, W., Bos-Kuijpers, M.,
O’Callaghan, J., Lammers, J., Waalkens-Berendsen. I., Waanders, M.M. and Gundersen,
H.-J.: Regulatory developmental neurotoxicity testing: a model study focusing on
conventional neuropathology endpoints and other perspectives. Environmental Toxicol.
and Pharmacol. 19: 745-755, 2005.
Kashon, M.L., Ross, G.W., O’Callaghan, J.P., Miller, D.B., Petrovich, H., Burchfiel,
C.M., Sharp, D.S. and White, L.R.: Associations of cortical astrogliosis with cognitive
performance and dementia status. J. Alzheimer’s Disease 6: 595-604, 2004.
Reed, M.D., Blair, L.F., Burling, K., Daly, I., Gigliotti, A.P., Gudi, R., Mercieca, M.D.
McDonald, J.D., Naas D.J., O’Callaghan, J.P., Seilkip, S.K., Ronsko, N.L., Wagner, V.O.
and Kraska, R.C.: Health effects of subchronic exposure to diesel-water emulsion
emission. Inhal. Toxicol. 17: 851-870, 2005.
Toscano, C.D., O’Callaghan, J.P. and Guilarte, T.R.: Extracellular regulated kinase ½ and
calcium/calmodulin dependent protein kinase II are differentially regulated in the
hippocampus of Pb2+-exposed rats. Brain Res. 1044: 51-58, 2005.
Sriram, K., Matheson, J.M., Benkovic, S.A., Miller, D.B., Luster, M.I. and O’Callaghan,
J.P. : Microglial activation and MPTP-induced neurotoxicity: Region-specific role for
TNF-α. FASEB J. 20: 670-682, 2006.
O’Callaghan, J.P. and Sriram, K.: GFAP and Other Glial Proteins as Biomarkers of
Neurotoxicity. Expert Opinion in Drug Safety 4: 433-442, 2005.
Groot, D.M.G., Hartgring, S., van de Horst, L., Moerkens, M., Otto, M., Bos-Kuijpers,
M.H.M., Kaufmann, W.S.H., Lammers, J.H.C.M., O’Callaghan, J.P., WaalkensBerendsen, I.D.H., Pakkenberg, B., Gundersen, H.J.G.: Two- and 3-D assessment of
neuropathology in rat brain after prenatal exposure to methylazoxymethanol, a model for
developmental neurotoxicity. Rep. Toxicol. 20: 417-432, 2005.
Parkin, M.C., O’Callaghan, J.P., Bole, D.G., Ueda, T. and Kennedy, R.T.: Sample
dependent effects on the neuropeptidome in rat brain tissue preparations detected by
capillary LC-MS. Analyt. Chem. 77: 6331-6338, 2005.
Wei, H., Dean, S.L., Parkin, M.C., Nolkrantz, K., O’Callaghan, J.P. and Kennedy, R.T.:
Microscale sample deposition onto hydrophobic target plates for trace level detection of
neuropeptides in brain tissue by MALDI-MS. J. Mass Spectroscopy 40: 1338-1346,
2005.
Benkovic, S.A., O’Callaghan, J.P. and Miller, D.B.: Regional neuropathology following
kainic acid intoxication in adult and aged C57Bl/6J mice. Brain Res. 1070: 215-231,
2006.
Sriram, K., Miller, D.B and O’Callaghan, J.P.: Minocyline attenuates microglial
activation but fails to mitigate striatal dopaminergic neurotoxicity: Role of TNF-α. J.
Neurochem. 96: 706-719, 2006.
Bowyer, J.F., Pogge, AR., Delonchamp, R.R., O’Callaghan, J.P., Patel, K.M., Vrana,
K.E. and Freeman, W.M.: A threshold neurotoxic exposure to amphetamine inhibits the
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expression of genes in the parietal cortex that are involved in synaptic plasticity.
Neuroscience 100: 428-436, 2007.
Little, A.R. and O’Callaghan, J.P.: CCL2 and its receptors are negatively regulated by
corticosterone in the rat brain. Neurosci. Lett. 399: 162-166, 2006.
Schulte, P., Ostry, A., Blanciforti, L.A., Cutlip, R., Krajnak, K., Luster, M., Munson, A.,
O’Callaghan, J., Parks, C., Simeonova, P., Wagner, G. and Miller, D.: Work, Obesity,
and Occupational Safety and Health. Am J. Public Health 97: 428-436, 2007.
Antonini, J.M., O’Callaghan, J.P. and Miller, D.B.: Development of an animal model to
study the potential neurotoxic effects associated with welding fume inhalation.
Neurotoxicology 27: 745-751, 2006.
Miller, D.B. and O’Callaghan, J.P.: The pharmacology of wakefulness. Metabolism 55:
S13-S19, 2006.
Damiani, C.L. and O’Callaghan, J.P.: Recapitulation of cell signaling events associated
with astrogliosis using the brain slice preparation. J. Neurochem. 100: 720-726, 2007.
Zinnanti, W.J., Lazovic, J., Housman, C., Towfighi, J., LaNoue, K., O’Callaghan, J.P.,
Woontner, M., Goodman, S.I., Connor, J.R. and Cheng, K.C.: Mechanism of agedependent susceptibility and novel treatment strategy in glutaric acidemia type I. J. Clin
Investigation. 117: 3258-3270, 2007.
Hubbs, A.F., Benkovic, S.A., Miller, D.B., Battelli, L.A., Schwegler-Berry, D. and Ma,
Q.Vacuolar Leukoencephalopathy with Widespread Astrogliosis in Mice Lacking
Transcription Factor Nrf2. Am. J. Pathol. 170: 2068-2076, 2007.
Benkovic, S.A., O’Callaghan, J.P. and Miller, D.B.: Exercise provides neuroprotection
without altering seizure susceptibility following kainic acid intoxication in C57Bl6/J
mice. J. Neurosci. (submitted).
Wei, H., Nolkrantz, K., Parkin, M.C., Chisolm, C.N., O’Callaghan, J.P. and Kennedy,
R.T.: Indentification and quantification of neuropeptides in brain tissue by capillary
liquid chromatography coupled off-line to MALDI-TOF and MALDI-TOF/TOF-MS.
Anal. Chem. 78: 4342-4351, 2006.
Reed, M.D., Blair, L.F., Burling, K., Daly, I., Gigliotti, A.P., Gudi, R., Mercieca, M.D.,
McDonald, J.D., O’Callaghan, J.P., Seilkop, S.K., Ronskoh, N.L., Wagner, V.O., Kraska,
R.C.: Health effects of subchronic exposure to diesel-water-methanol emulsion
emission.Toxicol. Ind. Health 22: 65-85, 2006.
Sriram, K. and O’Callaghan, J.P.: Divergent roles for tumor necrosis factor-α in the
brain. J. Neuroimmun. Pharm. 2: 140-153, 2007.
El-Fawal, H.A.N. and O’Callaghan, J.P.: Autoantibodies to neurotypic and gliotypic
proteins as biomarkers of neurotoxicity: assessment of trimethyltin (TMT).
Neurotoxicology 29: 109-115, 2008.
Scharf, M.T., Mackiewicz, Miroslaw, Naidoo, N., O’Callaghan, J.P. and Pack, A.I.:
AMP-activated protein kinase phosphorylation in brain is dependent on method of
sacrifice and tissue preparation. J. Neurochem. 105: 833-841, 2008.
Fox, D.A., Subbarao, V.K., Hamilton, W.R., Johnson, J.E. and O’Callaghan, J.P.: Lowlevel human equivalent gestational lead exposure produces supernormal scotopic
electroretinograms, increased retinal neurogenesis and decreased retinal dopamine
utilization in rats. Environ. Health Perspect. 116: 618-625, 2008.
Nishi A, Kuroiwa M, Miller D, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N,
Fukuda T, Heintz N, Greengard P, Snyder GL.Distinct roles of PDE4 and PDE10A in the
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regulation of cAMP/PKA signaling in the striatum. J Neurosci. 28: 10460-10471, 2008.
Meyer DA, Richer E, Benkovic S, Kansy JW, Hale C, Moy L, Kim Y, O'Callaghan JP,
Tsai L, Greengard P, Nairn AC, Cowan CW, Miller D, Antich P, Bibb JA.Striatal
dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and
dendritic morphology. PNAS 105: 18561-18566, 2008.
Wharton, S.B., O’Callaghan, J.P., Savva, G.M., Nicoll, J.A.R., Matthews, F., Simpson,
J.E., Forster, G., Shaw, P.J., Brayne, C. and Ince P.G.: Population variation in GFAP
levels in brain aging: Relationship to Alzheimer-type pathology and dementia. Dementia
and Geriatric Disorders 27: 465-473, 2009.
Magiatis, P., Polychronopoulos, P., Skaltsounis, A-L., Lozach, O., Meijer, L., Miller
D.B., and O’Callaghan, J.P.: Indirubins affect striatal monoamines and block striatal
damage in MPTP and kainite models of neurotoxicity. Neurotoxicology and Teratology
32: 212-219, 2010.
Benkovic, S.A., O’Callaghan, J.P. and Miller, D.B.: Protracted exposure to
supraphysiological levels of corticosterone does not cause neuronal loss or damage and
protects against kainic acid-induced neurotoxicity in the hippocampus of C57Bl/6J mice.
Neurotoxicology 30: 965-976, 2009.
Antonini, J.M., Sriram, K., Benkovic, S.A., Roberts, J.R., Stone, S., Chen, B.T.,
Schwegler-Berry, J, Jefferson, A.M., Billig, B.K., Felton, C.M., Ma, F., Hammer, M.
Frazer, D.G., James P. O’Callaghan, Diane B. Miller: Mild Steel Welding Fume Causes
Manganese accumulation and subtle neuroinflammatory changes but not overt neuronal
damage in discrete brain regions of rats after short-term inhalation exposure.
Neurotoxicology 30: 915-925, 2009.
Zhu, H., O’Brien, J., O’Callaghan, J.P., Miller, D.B., Zhang, Q., Rana, M., Tsui, T.,
Hendrick, J.P., Wennogle, L.P. and Snyder, G.L: Exposure to the nerve agent
diisopropyl-phosphorofluoridate (DFP) in vivo elicits site-specific and regionallyrestriced changes in protein phosphorylation in mouse brain. Brain Res. 1342: 11-23,
2010.
DiNapoli, V.A., Benkovic, S., Li, X., Kelly, K.A., Miller, D.B., Rosen, C.L., Huber, J.D.
and O’Callaghan, J.P.: Age exaggerates proinflammatory cytokine signaling and
truncates STAT3 signaling following ischemic stroke in the rat. Neuroscience 170: 633644, 2010.
Peng, Y, Zhang, Q., Snyder, G., Zhu, H., Yao, W., Tomesch, J., Papke, R.L.,
O’Callaghan, J.P., Welsh, W.J. and Wennogle, L.: Discovery of Novel Alpha7 Nicotinic
Receptor Antagonists. Bioorg. Med. Chem. Lett.20:4825-30, 2010.
O’Callaghan, J.P. and Miller, D.B.: Spinal glia and chronic pain. Metabolism 59, Supp. 1:
S21-S26, 2010
Little, A.R., Miller, D.B., Li, S., Kashon, M.L. and O’Callaghan, J.P.: Trimethyltininduced neurotoxicity: gene expression pathway analysis, q-rt-PCR and immunoblotting
reveal early effects associated with hippocampal damage and gliosis. Neurotoxicol.
Teratol. 34: 72-82, 2012.
Wichitnithad, W., O’Callaghan, J.P., Miller, D.B., Train, B.C. and Callery, P.S.: Timedependent slowly reversible inhibition of monamine oxidase A by N-substituted 1,2,3,6tetrhydropyridines. Bioorg.Med. Chem. 19: 482-4892, 2011.
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Xiao, L., O’Callaghan, J.P. and O’Donnell, J.M.: Effects of repeated treatment with
phosphodiesterase-4 inhibitors on cyclic AMP signaling, hippocampal neurogenesis, and
behavior in the forced-swim test. J. Pharmacol. Exp. Ther. 338: 641-647, 2011.
Fox, D.A., Hamilton, W.R., Johnson, J.E., Xiao, W., Chaney, S., Mukherjee, S., Miller,
D.B. and O’Callaghan, J.P.: Gestational lead exposure selectively decreases retinal
dopamine amacrine cells and dopamine content in adult mice. Toxicol. Appl. Pharmacol.
256: 258-267, 2011.
Torres-Altoro, M.I., Mathur, B.N., Drerup, J.M., Thomas, R., Lovinger, D., O’Callaghan,
J.P. and Bibb, J.A.: Organophosphates dysregulate dopamine signaling, glutamatergic
neurotransmission, and induce neuronal injury markers in striatum. J. Neurochem. 119:
303-313, 2011.
Mochel, F., Durant, B., Meng, X., O’Callaghan, J., Yu, H., Brouillet, E., Wheeler, V.C.,
Humbert, S., Schiffmann, R. and Durr, A.: Early alterations of brain cellular energy
homeostasis in Huntington disease models. J. Biol. Chem. 287: 1361-1370,
2012.
Ross, G.W., Duda, J.E., Abbott, R.D., Pellizzari, E., Petrovitch, H., Miller, D.B.,
O’Callaghan, J.P., Tanner, C.M., Noorigian, J.V., Masaki, K., Launer, L. and White,
L.R.: Relationship of Brain Organochlorine Levels with Lewy Pathology:
the Honolulu-Asia Aging Study. Movement Disorders 27: 1418-1424, 2012.
Kelly, K.A., Bowyer, J.F., Miller, D.B. and O’Callaghan, J.P.: Chronic exposure to
corticosterone enhances the neuroinflammatory and neurotoxic responses to
methamphetamine. J. Neurochem. 122: 995-1009, 2012.
Miller, D.B. and O’Callaghan, J.P. Personalized medicine in the diagnosis and treatment
of major depressive disorder-opportunities and pitfalls. Metabolism 62: S34-S39, 2013.
Jones, B.C., Miller, D.B., O’Callaghan, J.P., L. Lu., Unger, E.L., Alam, G., Williams,
R.W.: Systems analysis of genetic variation in MPTP neurotoxicity in mice.
Neurotoxicology 37: 26-34, 2013.
O’Callaghan, J.P., Kelly, K.A., Van Gilder, R.L., Sofroniew , M.V. and Miller, D.B.:
Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of
neurotoxicity PLoS ONE 9(7): e102003. doi:10.1371/journal.pone.0102003, 2014.
Robson, M., Turner, R., O’Callaghan, J.P. and Matsumoto, R.: SN79, a sigma receptor
antagonist, attenuates methamphetamine-induced astrogliosis through a blockade
of OSMR/gp130 signaling and STAT3 phosphorylation. Experimental Neurology 254:
180-89, 2014.
Snyder, G.L., Vanover, K.E., Zhu, H., Miller, D.B., O'Callaghan, J.P., Tomesch, J.,
Peng, L., Zhang, Q., Krishnan, V., Hendrick, J.P., Nestler, E.J., Davis, R., Wenogle, L.P.,
and Mates, S.: Unique functional profile of ITI-007, a modulator of serotonin, dopamine
and glutamate neurotransmission. Psychopharmacology (in press).
Matsumoto, R.R., Seminerio, M.J., Turner, R.C., Robson, M.J., Miller, D.B. and
O’Callaghan, J.P.: Methamphetamine-induced toxicity: an updated review on issues
relate to hyperthermia. Pharmacol. Ther. (in press).
O’Callaghan, J.P., Daughtrey, W.C., Clark, C.R., Schreiner, C.A. and White, R.: Health
Assessment of Gasoline and Fuel Oxygenate Vapors: Neurotoxicity Evaluation.
Regulatory Toxicol. Pharmacol. 70: S35-S42, 2014.
Gray, T.M., Steup, D., Roberts, L.G., O’Callaghan, J.P., Hoffman, G., Schreiner, C. and
Clark, C.R.: Health Assessment of Gasoline and Fuel Oxygenate Vapors: Reproductive
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Toxicity Assessment. Regulatory Toxicol Pharmacol. (in press).
Jones, B.C., O’Callaghan, J.P., Lu, L., Williams, R.W., Alama, G., Miller, D.B. Genetic
Correlational Analysis Reveals no Association between MPP+ and the Severity of
Striatal Dopaminergic Damage Following MPTP Treatment in BXD mouse strains.
Neurotoxicol. Teratol. 45: 91-92, 2014.
Panos, J.J., O’Callaghan, J.P., Miller, D.B. and Ferguson, S.A.: Effects of developmental
methylphenidate (MPH) treatment on monoamine neurochemistry of male and female
rats. Neurotoxicology 45: 70-74, 2014.
Miller, D.B. and O’Callaghan, J.P.: Biomarkers of Parkinson’s disease (PD): where we
are and where we are going. Metabolism 64: S40-6, 2015.
Elliott, A.S., Huber, J.D., O’Callaghan, J.P., Rosen, C.L. and Miller, D.B.: A review of
sleep deprivation studies evaluating the brain transcriptome. SpringerPlus 3: 728, 2014.
O’Callaghan, J.P., Kelly, K.A., Locker, A.R., Miller, D.B. and Lasley, S.M.:
Corticosterone Primes the Neuroinflammatory Response to DFP in Mice: Potential
Animal Model of Gulf War Illness J. Neurochem. 2015 Mar 5. doi: 10.1111/jnc.13088.
Roberts R., Aschner M., Calligaro D., Guilarte T.R., Hanig J.P., T Herr D., Hudzik, T.J.,
Jeromin, A., Kallman M.J., Liachenko S., Lynch J.J. III, Miller D.B., Moser V.C.,
O’Callaghan J., Slikker W. Jr., Paule, M.G. Translational Biomarkers of Neurotoxicity:
the Way Forward? Tox Sci. (in house review)
White, R.F., Steele, L., O’Callaghan, J.P., Sullivan, K., Barlow, C., Binns, J.H., Bloom,
F.E., Bunker, J.A., Crawford, F., Golomb, B.A., Graves, J.C., Hardie, A., Klimas, N,
Knox, M, Meggs, W., Melling, J., Ondra, S.L., Philbert, M.A., Grashow, R.: Gulf War
illness and other health problems in veterans of the 1990-1991 Gulf War: Effects of
exposures to neurotoxicants. Cortex (submitted).
Book Chapters, Conference Proceedings and Commentaries:
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Clouet, D.H., O'Callaghan, J.P. and Williams, N.: The effects of opiates on calciumstimulated phosphorylation of synaptic membrane proteins in intact synaptosomes from
rat striatum. In: Characteristics and Function of Opioids, eds: Van Ree and Terenius,
Elsevier/North Holland Biomedical Press, l978, pp 35l-352.
Clouet, D.H., O'Callaghan, J.P., and Williams, N: The effects of opiates on endogenous
phosphorylation of proteins in the synaptic plasma membranes of rat striatum. In:
Progress in Clinical and Biological Research, Vol. 27, Membrane Mechanisms of Drugs
of Abuse, eds: Sharp and Abood, Alan R. Liss, Inc., New York, l979, pp l0l-l2l.
Clouet, D.H. and O'Callaghan, J.P.: The role of protein kinases in opiate actions in brain.
In: Advances in Biochemical Psychopharmacology, Vol. 20, Neurochemical
Mechanisms of Opiate and Endorphins, eds: Loh and Ross, Raven Press, New York,
l979, pp. 281-300.
Billingsley, M.L., O'Callaghan, J.P. and Balaban, C.D. Pharmacologic and immunologic
approaches to the problems of posttraumatic glial proliferation following CNS damage.
In: Glial-Neuronal Communication in Development and Regeneration, NATO ASI Series
H, Cell Biology, Vol. II, Eds. H.H. Althaus and W. Seifert, Springer-Verlag, New York,
pp. 607-628, 1987.
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O'Callaghan, J.P.: Neurotypic and gliotypic proteins as biochemical markers of
neurotoxicity. Neurotoxicology and Teratology 10: 445-452, 1988.
O'Callaghan, J.P. and Miller, D.B.: Assessment of chemically-induced alterations in brain
development using assays of neuron- and glia-localized proteins. Neurotoxicology 10:
393-406, 1989.
McEwen, B.S., Brinton, R.E., Chao, H.M., Coirini, H., Gannon, M.N., Gould, E.,
O'Callaghan, J.P., Spencer, R., Sakai, R., Woolley, C.: The Hippocampus: A site for
modulatory interactions between steroid hormones, neurotransmitters and neuropeptides.
In: Neuroendocrine Perspectives, Volume VIII, Eugene E. Mueller & R. M. MacLeod,
Eds., pp. 93-131, Springer-Verlag, New York, 1990.
O'Callaghan, J.P.: The Use of Glial Fibrillary Acidic Protein in First Tier Assessments of
Neurotoxicity. J. Amer. Coll. Toxicol. 10: 719-726, 1991.
O'Callaghan, J.P.: Neurotypic and gliotypic proteins as biochemical indicators of
neurotoxicity. In: Neurotoxicology, M.B. Abou-Donia, ed., pp. 61-78, CRC Press, Boca
Raton, 1992.
O'Callaghan, J.P.: Assessment of neurotoxicity using assays of neuron- and glialocalized proteins: Chronology and Critique. In: Target Organ Toxicology Series:
Neurotoxicology, Hugh Tilson and Clifford Mitchell, Eds., Raven Press, Ltd., New York,
pp. 83-100, 1992.
O'Callaghan, J.P. and Jensen, K.F.: Enhanced expression of glial fibrillary acidic protein
and the cupric silver degeneration reaction can be used as sensitive and early indicators of
neurotoxicity. Neurotoxicol. 13: 113-122, 1992.
Breese, G.R., Criswell, H.E., Duncan, G.E., Johnson, K.B., Simson, P.E., Mueller, R.A.,
Jensen, K.F. and O'Callaghan, J.P.: Investigations of adaptive changes associated with
lesioning dopaminergic neurons with 6-hydroxydopamine. In: Progress in Parkinson's
Disease Research-2, F. Hefti and W.J. Weiner, Eds., Futura Publishing Co., Inc., Mount
Kisco, NY, pp. 259-274, 1992.
O'Callaghan, J.P. and Miller, D.B.: Quantification of reactive gliosis as an approach to
neurotoxicity assessment. In: Assessing Neurotoxicity of Drugs of Abuse. Erinoff, L.,
Ed., National Institute on Drug Abuse Monograph 136, pp. 188-212, Washington, D.C.,
U.S. Government Printing Office, 1993.
Jensen, K.F., Olin, J.K., Haykal-Coates, N., O'Callaghan, J.P., Miller, D.B. and de
Olmos, J.: Mapping toxicant-induced nervous system damage with a cupric silver stain.
A quantitative analysis of neural degeneration induced by 3,4-methylenedioxymethamphetamine (MDMA). In: Assessing Neurotoxicity of Drugs of Abuse. Erinoff, L., Ed.,
National Institute on Drug Abuse Monograph 136, pp 133-154, Washington, D.C., U.S.
Government Printing Office, 1993.
O'Callaghan, J.P.: Quantitative features of reactive gliosis following toxicant-induced
damage of the CNS. Ann. NY Acad. Sci. 679: 195-210, 1993.
Billingsley, M.L. and O'Callaghan, J.P.: Molecular Neurotoxicology. In: Principles of
Neurotoxicology. Chang, L.W. Ed., Marcel Dekker, Inc., New York, pp 551-562, 1994.
Breese, G.R., Criswell, H.E., Johnson, K.B., O'Callaghan, J.P., Duncan, G.E., Jensen,
K.F., Simson, P.E. and Mueller, R.A.: Neonatal destruction of dopaminergic neurons.
Neurotoxicology 15: 149-160, 1994.
O'Callaghan, J.P.: Biochemical analysis of glial fibrillary acidic protein as a quantitative
approach to neurotoxicity assessment: advantages, disadvantages and application to the
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assessment of NMDA receptor antagonist-induced neurotoxicity. Pyschopharmacol.
Bull. 30: 549-554, 1994.
O’Callaghan, J.P.: MDMA Neurotoxicity: Commentary on article by Ricaurte and
colleagues. Bull.of the Multidisciplinary Assoc. for Psychedelic Studies 6: 13, 1995.
O'Callaghan, J.P., Jensen, K.F. and Miller, D.B.: Quantitative aspects of drug and
toxicant-induced astrogliosis. Neurochem. Int. 26: 115-124, 1995.
Ali, S.F. and O'Callaghan, J.P.: Preface: Cellullar and Molecular Mechanisms of Drugs
of Abuse. Cocaine and Methamphetamine. Mol. Neurobiol. 11: vii, 1995.
Miller, D.B. and O'Callaghan, J.P.: The role of temperature, stress, and other factors in
the neurotoxicity of the substituted amphetamines: 3,4methylenedioxymethamphetamine and fenfluramine. Mol. Neurobiol. 11: 177-192,
1995.
Martin, P.M. and O'Callaghan, J.P.: Biochemical immunohistology. In: Central Nervous
System Trauma: Research Techniques, S.T. Ohnishi and T. Ohnishi, eds., CRC Press,
Boca Raton, FL, pp. 509-516, 1995.
Miller, D.B., Bartke, A. and O'Callaghan, J.P.: Increased glial fibrillary acidic protein
(GFAP) levels in the brains of transgenic mice expressing the bovine growth hormone
(bGH) gene. Experimental Gerontology 30: 383-400, 1995.
Martin, P.M. and O'Callaghan, J.P.: Gene expression in astrocytes after neural injury.
In: The Role of Glia in Neurotoxicity, M. Aschner and H.K. Kimmelberg, Eds. CRC
Press, Boca Raton, FL,pp. 285-310, 1996.
Miller, D.B. and O’Callaghan, J.P.: Neurotoxicity of d-amphetamine in the C57BL/6J
and CD-1 mouse: Interactions with stress and the adrenal system. Ann. New York Acad.
Sci. 801: 148-167, 1996.
O’Callaghan, J.P., Rogers, T.S., Rodman, L.E. and Page, J.G.: Acute and chronic
administration of ibogaine to the rat results in astrogliosis that is not confined to the
cerebellar vermis. Ann. NY Acad. Sci. 801:205-216, 1996.
O’Callaghan, J.P.: Reactive gliosis as an indicator of neurotoxicity. In: Obesity
Management and Redux™, S. Nicolaïdis, ed. Academic Press, London, pp. 43-47, 1997.
da Cruz e Silva, E.F. and O’Callaghan, J.P.: Phosphoprotein phosphatases as potential
mediators of neurotoxicity. In: Comprehensive Toxicology, Vol. 11, Nervous System and
Behavioral Toxicology, Sipes, G., McQueen, C.A and Gandolfi, A.J., eds. Elsevier
Science, London, 1997, pp 181-200.
Miller, D.B. and O’Callaghan, J.P.: Stress and adrenal system interactions with the
neurotoxicity of d-amphetamine in the female C57BL/6J mouse. Arquivos de Medicina
12: 123-129, 1998.
O’Callaghan, J.P.: Defining Neurotoxicity: Lessons from MDMA In: Ecstasy: The
Complete Guide. A Comprehensive Look at the Risks and Benefits of MDMA. Inner
Traditions, Rochester, VT , pp. 205-215, 2002.
O’Callaghan, J.P., Miller, D.B. and Pennypacker, K.R.: Chronic dopaminergic signaling
in the basal ganglia: A damage perspective on kinases and fos-related antigens. J.
Addiction Biol. 5: 369-376, 2000.
Miller, D.B., O’Callaghan, J.P. and Johnson, E. A.: Prior exposure to a behaviorally
sensitizing regimen of d-methamphetamine does not alter the striatal dopaminergic
damage induced by a neurotoxic regimen. Addiction Biol. 5: 361-367, 2000.
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Rowland, A.S., Umbach, D.M., O’Callaghan, J.P., Miller, D.B. and Dunnick, J.K.: Public
Health and Toxicological Issues Concerning Stimulant Treatment of ADHD. In:
Attention Deficit Hyperactivity Disorder: State of the Science•Best Practices. Peter M.
Jensen & James R. Cooper, eds., Civic Research Institute, Inc., Kingston, NJ 2002, pp.
10-1 – 10-16.
Little, A.R., Jr. and O’Callaghan, J.P.: The astrocyte response to neural injury: a review
and reconsideration of key features. In: Site-Selective Neurotoxicity. David Lester,
William Slikker &Philip Lazarovici, eds. Taylor and Francis Publishers, London, 2002,
pp. 233-265.
Miller, D.B., O’Callaghan, J.P. and Ali, S.F.: Age as a susceptibility factor in the striatal
dopaminergic neurotoxicity observed in the mouse following substituted amphetamine
exposure. Ann. NY Acad. Sci. 914: 194-207, 2000.
Hebert, M.A. and O’Callaghan, J.P.: Protein phosphorylation cascades associated with
methamphetamine-induced glial activation. Ann. NY Acad. Sci. 914: 238-262, 2000.
O’Callaghan, J.P. and Miller, D.B.: Neurotoxic effects of substituted amphetamines in
rats and mice: Challenges to the current dogma. In: Handbook of Neurotoxicity, Vol. 2,
E. J. Massaro, ed., Humana Press, Totowa, NJ, pp. 269-301, 2002.
O’Callaghan, J.P.: Measurement of glial fibrillary acidic protein. In: Current Protocols in
Toxicology. L.G. Costa, Ed., John Wiley & Sons, New York, pp. 12.81.1-12.8.12, 2002.
Tiffany-Castiglioni, E., Guerri, C., Aschner, M., Matsushima, G.K., O’Callaghan, J.P.
and Streit, W.J.: Roles of glia in developmental neurotoxicity: Session VI summary and
research needs. Neurotoxicology 22: 567-573, 2001.
Miller, D.B. and O’Callaghan, J.P.: Neuroendocrine aspects of the response to stress.
Metabolism 51: 5-10, 2002.
O’Callaghan, J.P.: Neurotoxic Esterase: Not so Toxic? Nature Genetics 33: 437-438,
2003.
Miller, D.B. and O’Callaghan, J.P.: Aging and stress: Implications for hipppocampal
structure and function. Metabolism 52: 17-21, 2003.
Sriram, K. and O’Callaghan, J.P.: Signaling mechanisms underling toxicant-induced
gliosis. In: The Role of Glia in Neurotoxicity”, Second Edition, Michael Aschner and
Lucio G. Costa, eds, CRC Press, Boca Raton, FL, pp. 141-171, 2005.
Bowyer, J.F., Harris, A., Jakab, R., Delongchamp, R., Miller, D. and O’Callaghan, J.:
cDNA array analysis of the changes in gene expression specifically produced by
neurotoxic doses of amphetamine: Not quite mission impossible. In: Emerging
Technologies in Neurotoxicology: Session III Summary and Research Needs. G. Jean
Harry, Ed., Neurotoxicology 25: 503-506, 2004.
Miller, D.B. and O’Callaghan, J.P.: Depression, Cytokines and Glial Function.
Metabolism 54: 33-88, 2005.
Miller, D.B. and O’Callaghan, J.P.: Aging, Stress and the Hippocampus. Aging Res.
Rev. 4: 123-140, 2005.
Berman, J.W., Carson, M.J., Chang, L., Cox, B.M., Fox, H.S., Gonzalez,
R.G., Hanson, G.R., Hauser, K.F., Ho, W.-A., Hong, J.-S., Major, E.O., Marago, W.F.,
Maslia, E., McArthur, J.C., Miller, D.B., Nath, A., O’Callaghan, J.P., Persidky, Y.,
Power, C., Roger, J.J., Royal, W.: NeurAIDS, Drug Abuse, and Inflammation: Building
Collaborative Research Activities. J. Neuroimmune Pharm. 1: 351-399, 2006.
Miller, D.B. and O’Callaghan, J.P.: Do Early Life Insults Contribute to the Development
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of the Late Life Diseases of Parkinson’s and Alzheimer’s? Metabolism 57: S44-49,
2008.
O’Callaghan, J.P., Sriram, K., and Miller, D.B.: Defining “Neuroinflammation”: Lessons
from MPTP- and Methamphetamine-Induced Neurotoxicity. Annal. NY Acad. Sci.
1139: 318-330, 2008.
Binns, J.H., Barlow, C., Bloom, F.E., Clauw, D.J., Golomb, B.A., Graves, J.C., Hardie,
A., Knox, M.L., Meggs, W.J., Nettlemen, M. D., O’Callaghan, J.P., Smithson, S., Steele,
L., White, R.F.: Gulf War Illness and the Health of Gulf War Veterans: Scientific
Findings and Recommendations. Research Advisory Committee on Gulf War Vetereans’
Illnesses. Gov. Printing Office, November 2008.
Da Cruz e Silva, E.F. and O’Callaghan, J.P.: Protein phosphatase 1 as a potential
mediator of aluminum neurotoxicity. In: Comprehensive Toxicology, Vol. 13, Martin
Philbert, ed. Elsevier, 2010.
Zhang, D., Hu, X., Li, Q., O’Callaghan, J.P. and Hong, J.-S.: Astrogliosis in CNS
pathologies: Is there a role for microglia. Molecular Neurobiol. 41: 232-241, 2010.
Turner, R.C., Lucke-Wold, B., Miller, D.B., O’Callaghan, J.P., Rosen, C.L. and Huber,
J.D. Neuropoietic cytokines and neural injury: alterations in JAK2/STAT3 signaling
associated with aging. In: “Neurological Disorders-New Research”, C.E. Thomas and
J.R. Moore, Eds., Nova Science Publishers, Hauppauge NY, pp 27-48, 2012.
Binns, J.H., Bloom, F.E., Bunker, J.A., Crawford, F., Golomb, B.A., Graves, J.C.,
Klimas, N., O’Callaghan, J.P., Ondra, S.L., Philbert, M.A., Steele, L., White, R.F.: Gulf
War Illness and the Health of Gulf War Veterans: Research Update and
Recommendations, 2009-2013. Gov. Printing Office, 2014
Internet highlights:
Global Medical Discovery: STAT3 PLOSone paper highlight:
https://globalmedicaldiscovery.com/key-scientific-articles/early-activation-stat3-regulatesreactive-astrogliosis-induced-diverse-forms-neurotoxicity/
Congressionally Directed Medical Research Program Gulf War Illness grant highlight:
http://cdmrp.army.mil/gwirp/research_highlights/14Lasley_OCallaghan_highlight.shtml
Corrigendum:
J. Neurosci. Methods 43: 231, 1992.
Letter to the Editor:
Goldey, E.S., O’Callaghan, J.P., Stanton, M.E. and Crofton, K.M. Re: Dose as central variable in
toxicology. Fund. App. Toxicol. 24: 290, 1995.
Centers for Disease Control and Prevention-NIOSH Reports:
NIOSH Alert: Hazardous Drugs-update April, 2010-2011
Veterans Administration:
Gulf War Research Strategic Plan (Draft)- December, 2011
U.S. Environmental Protection Agency Reports:
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Proposed Preregulatory Investigation: Paints and Allied Products. Chemical Control
Division, Office of Toxic Substances, OPTS, 1981.
An evaluation of nervous-system specific proteins as biochemical indicators of
neurotoxicity. New Funding Initiative for Office of Pesticides and Toxic Substances,
1983.
Nervous-system-specific proteins as biochemical indicators of neurotoxicity. Major
ORD Accomplishment Report, Office of Research and Development, 1985.
Draft Report on Biomarker Research in Neurotoxicology. Office of Health Research,
ORD, 1987.
Use of monoclonal antibodies in neurotoxicological research. Administrator Initiative
Item, 1987.
Draft Guideline: Use of Assays of GFAP in the Assessment of Developmental
Neurotoxicity. OPTS, 1988.
Draft Guideline: Use of Assays of GFAP in Neurotoxicity Risk Assessment. OPTS,
1989.
Major Milestone, Superfund Research: Report on Characterization of Novel Nervous
System Specific Proteins, 1989.
Progress Report: NIDA/EPA Interagency Agreement RA-ND-89-4, "Interdisciplinary
Assessment of the Neurotoxic Effects of MDMA, MPTP, Cocaine and THC" (10/89).
Deliverable # 3121: Potential Biomarkers for Neurotoxic Effects. Office of Health
Research, ORD (8/90).
Contributor: ORD Health Biomarkers Program; Research Strategy Document. Office of
Research and Development EPA/600/9-91/009, April 1991.
Progress Report: NIDA/EPA Interagency Agreement 1-Y01 DA 30063, "Neurotoxicity
of Ibogaine" (12/93).