Introduction A headache of some type occurs in approximately 90% of the population each year. It is most unusual to encounter a person who denies having a headache of some type during their entire life. Headache is the presenting complaint of 2– 4 % of patients seeking care in emergency room or in the office of a primary care physician. When including the indirect cost of time lost from not being fully productive at work, travel for unnecessary imaging studies, emergency room visits, etc, migraine is estimated to be a thirty billion dollar illness in the USA. With proper medical care most patients with headache can be helped. Most treatments for the primary headache disorders are not “evidence based” but have been learned from past clinical experience. For example there has never been a double blind study proving that aspirin or acetaminophen improve a simple tension-type headache. The following a is a series of short reviews of various aspects of headache designed to compliment the lectures and clinical teaching that medical students and residents might have had in the past. Like information that is spoken during a lecture, there will be no references to printed material. Further information can be obtained by searching the internet. If necessary these short notes will be updated from time to time as new information develops. John S. Warner, M.D. Professor, Emeritus Department of Neurology Vanderbilt University School of Medicine Nashville, Tennessee