3rd Annual Meeting
Predict-IV
Profiling the toxicity of new drugs: a non animal-based approach integrating
toxico-dynamics and biokinetics
(Grant agreement No. 202222)
May 26th – 27th 2011
Hotel Maritim Antonine & Spa, Mellieha Bay, Malta
AGENDA
26.05.2011
In response to a request from Dr. Janet Mifsud from the Department of Clinical Pharmacology and
Therapeutics, University of Malta, the Project Steering Committee agreed to open the Young Scientist
Session (Talks and Posters) to interested Maltese researchers in this field.
9:00
Welcome address and general project presentation by Wolfgang Dekant
Young Scientist Session (Talks)
10:10 – 10:25
Alice Limonciel: Identification of lactate as a sub-lethal injury marker and its application
for repeat dose testing
Lydia Aschauer: Identification of transcriptomic alterations in renal epithelial monolayer
formation and their functional implications
Anja Wilmes: Long term Cyclosporin A increases transepithelial electrical resistance in
renal proximal tubule monolayers: a possible role of claudin rearrangement
Germaine Truisi: Primary hepatocytes – a model for early toxicity and drug metabolism
screening
Eliane Alexandre: First Year results with Human Hepatocytes
10:25 – 10:50
Coffee break
09:10 – 09:25
09:25 – 09:40
09:40 – 09:55
09:55 – 10:10
10:50 – 11:05
11:05 – 11:20
11:20 – 11:35
11:35 – 11:50
11:50 – 12:05
12:05 – 12:30
Anaelle da Costa: In vitro blood-brain barrier model adapted to repeated dose
toxicological screening
Jessica Broeders: In Vitro Kinetics of Chlorpromazine after Repeated Exposure in
Different Cell Systems
Olga Schmal: Monitoring of ciclosporin A kinetics in kidney and liver cells in vitro
David Germano: High Content Imaging Approach in Rat Hepatocytes Long Term
Culture to Predict Drug-Induced Liver Toxicity
Silke Ruzek: Quantitative Proteomic Profiling using µHPLC-MS/MS for Toxicity
Prediction in Human Organ Model Systems
Poster Session
Presentation of work-package results
12:30 – 12:45
WP 1
Compound selection and generation of in vivo and in vitro database
Involved: P1, P7, P18, P20
Responsible: P1, Wolfgang Dekant and Christof Burek
12:45 – 13:00
SDRS
Data received, data available, data missing (Arno Lukas?)
13:00 – 14:00
Lunch Break
14:00 – 14:10
WP 2
14:10 – 14:30
WP 2.1
14:30 – 14:50
WP2.3
14:50 – 15:10
WP 2.2
15:10– 15:20
WP 2.5
15:20–15:40
WP 2.4
15:40 – 16:00
WP 3
16:00 – 16:20
Coffee Break
16:20 – 16:40
WP 4.1
16:40 – 17:00
WP 4.2
17:00 – 17:20
WP 5
17:20 – 17:30
WP 6
17:30 – 18:00
19:30
Human and animal in vitro cellular models for the prediction of organ
specific adverse effects of therapeutic compounds
Involved: P3, P2, P6, P8, P9, P10, P11, P16, P17, P19, P20
Responsible: P3, Walter Pfaller and Paul Jennings
Long-term human models for hepatotoxicity
Involved: P2, P9, P10
Responsible: P2, Phil Hewitt
In vitro models for CNS toxicity testing
Involved: P6, P16, P17, P19, P20
Responsible: P6, Anna Price
Human based cellular systems for nephrotoxicity testing
Involved: P3, P8, P11
Responsible: P3, Walter Pfaller and Paul Jennings
Bioactivation co-culture models for toxicity testing
Involved: P2, P3, P6, P10, P11, P16, P17
Responsible: P3, Walter Pfaller, Paul Jennings and P2, Phil Hewitt
Long-term human models for non target organ specific toxicity
Involved: P3, P8, P11
Responsible: P11, Martin Leonard
Non animal-based models for in vitro kinetics and human kinetic
prediction
Involved: P4, P1, P5, P9, P12
Responsible: P4, Emanuela Testai
“omics” profiling methods
Involved: P2, P6, P1, P3, P7, P14, P21
Responsible: P2, Phil Hewitt and P6, Claude Guillou
High-content image analysis of toxic effects and identification of
toxicity pathways in human cell models
Involved: P8, P2, P3, P9, P10
Responsible: P8, Armin Wolf
An integrated modelling approach for in vitro - in vivo extrapolations
Involved Partners: P5, P6, P7, P13, P18
Responsible: P5, Frederic Yves Bois
Monitoring European efforts, building blocks, and industry
input/needs
Involved: P2, P6
Responsible: P2, Stefan O. Mueller
Open discussion
Administrative matters (e.g. appointment of a publication review board)
Dinner (not covered from project costs)
27.05.2011
9:00 – 9:45
Cyclosporin Data presentation – A catalyst for analysis / interpretation / combining
different data types
Phil Hewitt, Paul Jennings, Christof Burek
Future work
9:45 – 9:50
9:50 – 10:20
10:20 – 10:50
Short overview about WP-specific sessions
WP 5
Specific problems, needs from other WPs and partners, expected
output and time-lines
Frederic Yves Bois
WP 4
Specific problems, needs from other WPs and partners, expected
output and time-lines
Phil Hewitt and Armin Wolf
10:50 – 11:10
Coffee break
11:10 – 11:40
WP 3
11:40 – 12:30
WP 2
12:30 – 13:30
Lunch
13:30 – 14:30
14:30 –
Mini Break-out sessions (if needed)
Outcome / General discussion
15:00 – 15:20
Coffee break
16:00
Proposed end of meeting
Specific problems, needs from other WPs and partners, expected
output and time-lines
Emanuela Testai and Christof Burek
Specific problems, needs from other WPs and partners, expected
output and time-lines
Paul Jennings, Anna Price and Phil Hewitt