Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons, and Emergency Department Visits in Kentucky, 2000‐2012 January, 2014 Prepared by Svetla Slavova, PhD Terry L. Bunn, PhD Joshua W. Lambert, MS Released by Kentucky Injury Preven on and Research Center (KIPRC) 333 Waller Avenue, Suite 242 Lexington, Kentucky 40504 For more informa on contact Svetla Slavova E‐mail: ssslav2@email.uky.edu Table of Contents: Executive summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 2000‐2012. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Drug overdose hospitalizations, 2000‐2012. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12 Drug overdose emergency department visits, 2008‐2012. . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Medicaid recipient opiate overdose hospitalizations and emergency department visits. . . 27 Opioid‐related disease condition hospitalizations, 2000‐2012. . . . . . . . . . . . . . . . . . . . . . . . .32 Neonatal abstinence syndrome hospitalizations, 2000‐2012. . . . . . . . . . . . . . . . . . . . . . . . . .37 Appendix A. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Conclusions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 About this report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 1 Execu ve Summary 1. The total number of Kentucky resident drug overdose deaths leveled off from 2011 to 2012 (1,022 deaths in 2011 and 1,031 deaths in 2012). 2. The Kentucky resident age‐adjusted drug overdose mortality rate decreased from 24.2 in 2011 to 23.9 in 2012 (1.2% decrease). 3. Pharmaceu cal opioids remained the primary cause of Kentucky resident drug overdose deaths in 2012; pharmaceu cal opioids accounted for 471 drug overdose deaths. 4. Heroin contributed to 129 Kentucky resident drug overdose deaths in 2012, a 207% increase from the 42 heroin‐involved deaths recorded in 2011. 5. Benzodiazepines contributed to 362 Kentucky resident overdose deaths in 2012, decreasing 16% from 2011. 6. Kentucky age‐adjusted drug overdose hospitaliza on rates decreased 2.4% from 2011 to 2012, from 146.6 hospitaliza ons/100,000 popula on in 2011 to 143.1 in 2012. 7. Intent to self‐harm was the primary reason for 2012 Kentucky resident inpa ent hospitaliza ons, simi‐ lar to years 2000‐2011. 8. Benzodiazepines were the primary drugs involved in Kentucky resident inpa ent hospitaliza ons in 2012 decreasing 11% to 1,686 hospitaliza ons in 2012. 9. Pharmaceu cal opioids were the second leading drug type involved in drug overdose related hospitali‐ za ons in 2012, decreasing 8% from 1,610 hospitaliza ons in 2011 to 1,483 in 2012. 10. Total charges for drug overdose hospitaliza ons rose 7% from $121.1 million in 2011 to $129.3 million in 2012. 11. The primary expected payer source for Kentucky resident drug overdose inpa ent hospitaliza ons was Medicare followed by Medicaid for 2011 and 2012; Medicare was billed $41.3 million and Medicaid was billed $34.1 million in 2012. 12. Casey, Carroll, Nicholas, Powell, and Johnson coun es had the highest Kentucky resident drug over‐ dose emergency department (ED) visit rates, 2008‐2012. 2 Execu ve Summary (cont’d) 13. Kentucky resident drug overdose ED visit numbers and rates leveled off in 2012 from 6,496 visits and an age‐adjusted rate of 153.1 visits/100,000 popula on in 2011 to 6,492 visits and an age‐adjusted rate of 153.0 in 2012. 14. Kentucky resident drug overdose ED visit charges increased 5% from $14.6 million in 2011 to $15.3 mil‐ lion in 2012. 15. Self‐pays were the primary payer billed for drug overdose ED admissions in 2012 at $5 million; Medi‐ caid was billed $4.2 million and commercial insurance was billed $3.6 million. 16. Benzodiazepines were the primary drugs involved in Kentucky drug overdose ED visits in 2012 with 856 visits; pharmaceu cal opioid involvement decreased 6% to 721 visits in 2012. 17. Heroin involvement in drug overdose related ED visits increased 197% from 266 ED visits in 2011 to 789 visits in 2012. 18. Medicaid recipient total drug overdose ED charges totaled $740,000 in 2012, a 27% increase from a total of $584,000 charged in 2011. 19. Medicaid recipient total drug overdose inpa ent hospitaliza on charges totaled $11 million in 2012, approximately the same as in 2011. 20. Kentucky resident opioid‐related disease condi on hospitaliza on charges totaled $167 million in 2012; Medicaid was billed for $55 million. 21. There were 824 Kentucky resident neonatal abs nence syndrome hospitaliza ons. Associated charges amounted to $40 million; Medicaid was charged $35 million. 22. Of the 9,713 pharmaceu cal opioid or heroin related hospitaliza ons in 2012, viral hepa s was co‐ diagnosed for 1,653 (17%) of them with associated charges of $37 million. 23. There were 1,192 hospitaliza ons involving opioid drug dependence and viral hepa increase over the 976 hospitaliza ons in 2011. 3 s in 2012, a 22% Drug Overdose Deaths 2000‐2012 4 Kentucky Resident Drug Overdose Deaths, 2000‐2012 1200 1000 Total Number 800 711 673 747 746 2008 2009 996 1,022 1,031 2010 2011 2012 621 600 551 525 2003 2004 435 400 339 246 200 0 2000 2001 2002 2005 2006 2007 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. Kentucky Resident Age‐Adjusted Drug Overdose Mortality Rates, 2000‐2012 Mortality Rate (# Deaths /100,000 Population) 30 25 23.3 24.2 23.9 2010 2011 2012 20 16.9 14.8 15 13.4 17.4 17.3 2008 2009 15.8 12.7 10.6 10 8.3 6.1 5 0 2000 2001 2002 2003 2004 2005 2006 2007 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. 5 Kentucky Resident Drug Overdose Deaths by Gender, 2000‐2012 622 613 614 700 287 409 382 409 444 303 238 268 220 203 Male Female 158 132 161 206 228 300 200 322 276 322 400 84 Total Number 400 435 443 500 459 600 100 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. Kentucky Resident Age‐Adjusted Drug Overdose Mortality Rates by Gender, 2000‐2012 18.5 19.1 17.6 13.1 13.8 Female 11.0 12.4 10.4 29.2 28.9 21.6 21.3 20.6 19.4 15.7 Male 7.6 6.4 8.0 10.2 10.8 15 9.7 13.7 15.8 20 5 21.5 25 4.0 Mortality Rate (# Deaths/100,000 Population) 30 10 29.3 35 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. 6 874 912 1000 900 911 Kentucky Resident Drug Overdose Deaths by Intent, 2000‐2012 800 612 620 546 590 533 265 400 300 Self Harm 355 500 Unintentional 443 472 600 204 Total Number 700 Undetermined 62 58 50 59 55 67 56 78 60 67 67 60 65 54 47 41 46 34 45 33 48 26 9 33 100 59 20 200 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. 20.8 20.9 20.1 25 14.2 14.5 12.8 12.7 Unintentional 10.7 11.5 15 14.0 20 8.7 Self Harm Undetermined 5.0 6.5 10 1.4 1.3 1.1 1.4 1.3 1.5 1.3 1.8 1.4 1.6 1.6 1.4 1.5 1.3 1.1 1.0 1.1 0.8 1.1 0.8 1.4 0.5 1.2 0.6 5 0.8 0.2 Crude Mortality Rate (# Deaths/100,000 Population) Kentucky Resident Crude Drug Overdose Mortality Rates by Intent, 2000‐2012 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. 7 8 Opiates/opioids Heroin Pharmaceutical Opioids Methadone Cocaine Other and unspecified narcotics Drugs not elsewhere classified or unspecified Nonopioid analgesics Antiepileptic, sedative‐hypnotic, anti‐ Parkinsonism, antidepressant, and other psychotropic drugs, not elsewhere classified. Benzodiazepines Narcotics and psychodysleptics not elsewhere classified 149 0 149 73 30 22 222 173 193 1 192 116 27 23 284 218 229 188 T40(.0‐.4) T40.1 T40.0, T40(.2‐.4) T40.3 T40.5 T40.6 T50.9 T50.9 Only 29 45 T42.4 T36‐T38.9, T40(.0‐.9), T41, T44, T45(.0‐.4), T45(.6‐.9), T46‐T50.8 25 87 16 87 190 0 190 118 32 26 284 205 231 31 23 78 239 0 239 136 53 28 327 233 300 41 28 84 248 1 247 126 48 15 274 222 296 23 33 51 243 0 243 106 36 14 281 221 282 33 27 64 265 4 262 89 36 17 279 232 299 54 36 93 285 14 271 53 15 22 273 215 312 84 9 98 480 34 449 96 31 30 606 289 522 279 7 307 568 42 538 95 25 79 793 307 656 430 7 467 569 129 471 76 50 89 796 299 677 362 8 405 Year 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 T39 T42, T43 Kentucky Resident Drug Overdose Deaths by Contributing Drugs Contributing Drug ICD‐10 code 9 Occurrences of Specific Drugs among the Contributing Causes for Kentucky Resident Drug Overdose Deaths, 2011‐2012 15 24 Hydromorphone 20 16 Tramadol 34 Fentanyl Clonazepam Cocaine 25 54 2012 50 54 2011 50 64 Diazepam Morphine 52 78 66 66 Oxymorphone 90 76 Methadone Heroin 92 129 42 173 Hydrocodone 203 188 Oxycodone 257 205 Alprazolam 0 50 100 150 Total Number 200 276 250 300 Produced by the Kentucky Injury Prevention and Research Center, November 2013. Data source: Kentucky Vital Statistics electronic death certificate file. Data for 2009‐2012 are provisional and subject to change. 10 11 Drug Overdose Hospitaliza ons 2000‐2012 12 Kentucky Resident Drug Overdose Hospitalizations, 2000‐2012 7,000 6,000 4,963 5,000 Total Number 4,024 4,312 4,531 4,626 4,524 2002 2003 2004 2005 5,244 5,320 2007 2008 5,626 5,749 2009 2010 6,422 6,296 2011 2012 4,000 3,372 3,000 2,000 1,000 0 2000 2001 2006 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Age‐Adjusted Rate (# hospitalizations/ 100,000 population) 160 Kentucky Resident Age‐Adjusted Drug Overdose Hospitalization Rates, 2000‐2012 146.6 140 117.6 120 98.4 100 105.1 110 111.6 2002 2003 2004 123.3 124 2007 2008 129.7 132.1 2009 2010 143.1 108.1 82.6 80 60 40 20 0 2000 2001 2005 2006 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 13 1,933 2003 2004 2005 2,619 2,688 2,410 3,290 2,336 3,147 2,173 3,100 2,836 2,144 1,909 2,127 2,591 2,678 1,853 1,724 1,581 2,000 1,500 2,588 2,443 1,989 2,500 1,383 Total Number 3,000 2,717 3,500 3,339 4,000 3,677 3,734 Kentucky Resident Drug Overdose Hospitalizations by Gender, 2000‐2012 Male Female 1,000 500 0 2000 2001 2002 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 163.6 167.3 121.8 125.6 113.7 150 148.9 110.8 104.1 121.5 131.8 102.7 2004 103.3 2003 94.8 127.2 123.1 94.4 80 91.9 100 79.6 95 120 86.5 116.7 140 128.8 160 143.2 143.3 180 69.7 Hospitalization Rate (#hospitalizations/ 100,000 population) Kentucky Resident Age‐Adjusted Drug Overdose Hospitalization Rates by Gender, 2000‐2012 Male Female 60 40 20 0 2000 2001 2002 2005 2006 2007 2008 2009 2010 2011 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 14 2012 2,642 2,221 2,252 1,018 445 1,014 441 409 2,530 333 407 719 823 1,691 726 1,497 665 558 1,404 610 549 1,955 1,999 2,497 2,566 2,521 2,398 2,186 1,271 560 569 542 525 1,080 1,147 2,281 2,254 486 523 536 561 957 987 500 751 1,000 509 660 1,738 1,500 404 477 Total Number 2,000 2,027 2,500 2,346 3,000 2,708 Kentucky Resident Drug Overdose Hospitalizations by Intent, 2000‐2012 0 2,000 2,001 2,002 2,003 2,004 Unintentional 2,005 2,006 Self Harm 2,007 Undetermined 2,008 2,009 2,010 2,011 2,012 No Ecode 45.0 50.7 51.5 60.3 62.0 58.2 57.9 59.8 23.2 23.2 10.2 16.7 18.9 10.1 9.3 10.0 9.4 7.8 16.9 39.4 15.6 13.1 35.2 14.5 13.0 13.0 12.6 30.4 13.5 13.7 27.7 26.2 12.4 16.0 11.9 12.9 10.0 11.8 13.1 13.7 23.4 24.3 30.0 33.3 40.0 20.0 59.2 56.8 42.9 50.0 46.3 49.8 60.0 52.3 55.4 55.1 70.0 56.6 Kentucky Resident Drug Overdose Hospitalization Rates by Intent , 2000‐2012 18.5 Hospitalization Rate (# hospitalizations/100,000 population) Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 0.0 2000 2001 2002 Unintentional 2003 2004 Self/Harm 2005 2006 2007 Undetermined 2008 2009 2010 2011 No Ecode Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 15 2012 16 Other Unspecified Anticoagulants Psychostimulants Benzodiazepines Antidepressants Cocaine Methadone Pharmaceutical Opioids Heroin Opiates/opioids 4‐Aminophenol Nonopioid analgesics DRUG ICD‐ 9‐CM Codes For ICD‐9‐CM codes see Appendix A Kentucky Resident Drug Overdose Related Hospitalizations Drug Type 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 118 67 509 10 112 147 577 16 591 404 714 73 184 658 21 677 414 723 75 206 718 14 731 430 740 81 163 717 11 728 438 731 85 215 921 41 957 562 830 587 875 608 906 546 826 587 880 496 793 39 62 48 62 170 93 226 72 201 81 190 104 189 213 194 217 168 961 1,030 1,201 1,254 1,610 1,483 30 988 1,065 1,259 1,298 1,668 1,637 571 877 67 93 74 93 90 96 110 107 90 106 90 102 106 94 110 84 125 111 135 112 80 203 77 180 1,755 1,972 2,190 2,198 2,231 2,212 2,489 2,546 2,769 2,845 3,009 3,369 3,410 87 63 793 1,120 1,181 1,181 1,245 1,196 1,386 1,511 1,561 1,661 1,645 1,885 1,686 1,781 2,275 2,389 2,487 2,529 2,461 2,667 2,849 2,973 3,032 3,044 3,479 3,250 90 31 332 8 519 379 351 339 644 590 3,372 4,024 4,312 4,531 4,626 4,524 4,963 5,244 5,320 5,626 5,749 6,422 6,296 2000 Year Total Charges for Drug Overdose Hospitalizations, 2000‐2012 $140.0 $129.3 $121.1 $120.0 $100.0 Dollars (in millions) $87.8 $93.0 $77.4 $80.0 $69.3 $61.3 $60.0 $43.8 $40.0 $48.2 $50.6 $33.7 $21.1 $26.2 $20.0 $0.0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Drug Overdose Hospitalizations by Total Length of Stay, 2000‐2012 25,000 21,594 21,344 20,000 17,802 17,832 19,004 18,664 15,839 Total Days of Hospital Stay 15,000 13,768 15,061 14,635 14,285 12,367 10,385 10,000 5,000 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 17 Kentucky Resident Drug Overdose Hospitalizations by Expected Payer, 2000‐2012 2,000 1,800 1,600 Total Number 1,400 1,200 1,000 800 600 400 200 0 2000 2001 2002 2003 Commercial 2004 2005 Medicaid 2006 Medicare 2007 2008 Other 2009 2010 2011 2012 Self Pay or Charity Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Kentucky Resident Total Drug Overdose Hospitalization Charges by Expected Payer, 2000‐2012 $45 $40 $35 Dollars (in millions) $30 $25 $20 $15 $10 $5 $0 2000 2001 2002 2003 Commercial 2004 2005 Medicaid 2006 Medicare 2007 Other 2008 2009 2010 2011 Self Pay or Charity Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 18 2012 19 Drug Overdose Emergency Department Visits 2008‐2012 20 Kentucky Resident Drug Overdose Emergency Department Visits, 2008‐2012 7,000 6,000 5,917 5,778 2009 2010 6,496 6,492 2011 2012 5,414 Total Number 5,000 4,000 3,000 2,000 1,000 0 2008 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Age‐adjusted rate (# ED visits/ 100,000 population) Kentucky Resident Age‐Adjusted Drug Overdose Emergency Department Visit Rates, 2008‐2012 170 150 130 139.5 136.5 2009 2010 129.4 153.1 153.0 2011 2012 110 90 70 50 30 10 ‐10 2008 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 21 Kentucky Resident Drug Overdose Emergency Department Visits by Gender, 2008‐2012 3,479 3,024 3,017 3,120 2,658 2,659 2,362 Total Number 3,000 2,500 3,258 3,052 3,500 3,468 4,000 2,000 Male 1,500 Female 1,000 500 0 2008 2009 2010 2011 2012 Kentucky Resident Age‐Adjusted Drug Overdose Emergency Department Visit Rates by Gender, 2008‐2012 120 163.1 142.6 142.4 147 125.7 125.9 140 145 160 153.3 180 163.2 200 113.5 Age‐adjusted rate (# ED visits/100,000 population) Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 100 Male 80 Female 60 40 20 0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 22 Kentucky Resident Drug Overdose Emergency Department Visits by Intent, 2008‐2012 3,157 1,092 490 596 599 900 690 869 634 766 1,500 1,000 1,547 1,084 1,642 1,742 1,715 1,646 2,608 2,289 Total Number 3,000 2,000 2,629 3,500 2,500 3,354 4,000 500 0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Unintentional Self Harm Undetermined No Ecode 72.3 24.9 35.3 24.7 11.2 13.7 13.7 20.6 16.0 14.8 20 17.9 30 20.1 40 37.7 37.8 40.4 40.0 50 60.5 70 60.6 80 60 76.6 90 53.4 Crude rate (# ED visits/100,000 population) Kentucky Resident Crude Drug Overdose Emergency Department Visit Rates by Intent, 2008‐2012 10 0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Unintentional Self Harm 23 Undetermined No Ecode Kentucky Resident Total Drug Overdose Emergency Department Visit Charges, 2008‐2012 $18 $16 $15.3 $14.6 $14 Dollars (in millions) $12.0 $11.4 $12 $9.4 $10 $8 $6 $4 $2 $0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. $5.0 $6 Kentucky Resident Total Drug Overdose Emergency Department Visit Charges by Expected Payer, 2008‐2012 $1.8 $2.3 $2.5 $3.6 $4.2 $4.3 $3.8 $3.7 $0.3 $0.3 $0.2 $0.3 $3.1 $3.2 $1.7 $0.3 $1 $3.3 $2.9 $3.4 $1.9 $2 $1.5 $3 $2.9 $2.8 Dollars (in millions) $4 $3.6 $5 $0 2008 2009 Commercial 2010 Medicaid Medicare 2011 Other 2012 Self Pay or Charity Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 24 Kentucky Resident Drug Overdose Related ED Visits 2008 5,414 2009 5,917 Year 2010 5,778 Nonopioid analgesics, Antipyretics, and Antirheumatics 805 831 776 764 737 4‐Aminophenol derivatives 428 462 418 420 379 590 725 816 73 142 211 266 789 518 585 614 769 721 54 48 52 43 58 42 37 45 67 88 2,033 2,179 2,075 804 907 866 939 856 133 143 140 199 172 65 104 88 57 54 3,195 3,500 3,455 For ICD‐9‐CM codes see Appendix A DRUG Involved Opiates/opioids Heroin Pharmaceutical Opioids Methadone Cocaine Antidepressants, barbiturates and other antiepileptics, sedative‐ hypnotics, and psychotropic drugs not elsewhere classified Benzodiazepines Psychostimulants with abuse potential including methamphetamine, MDMA (Ecstasy) Anticoagulants Other specified and unspecified drugs 2011 2012 6,496 6,492 1,026 1,488 2,320 2,200 3,864 3,651 Kentucky Resident Drug Overdose Emergency Department Visits by Drugs Involved, 2008‐2012 518 721 789 856 614 585 700 ‐100 2008 Benzodiazepine 2009 2010 Pharmaceutical Opioids 88 45 67 211 37 42 142 300 100 266 500 73 Total Number 939 769 804 900 866 907 1,100 2011 Heroin 2012 Cocaine Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 25 26 Medicaid Recipient Opiate Overdose Hospitaliza ons and Emergency Department Visits 27 Medicaid Recipient Opiate Overdose Hospitalizations by Gender, 2000‐2012 280 350 2004 148 128 2007 Female 102 128 188 55 2003 90 80 51 2002 Male 153 139 2006 90 83 52 2001 70 75 80 41 2000 100 112 121 150 137 200 50 198 250 32 42 Total Number 254 300 0 2005 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Medicaid Recipient Opiate Overdose Hospitalizations by Intent, 2000‐2012 191 250 173 101 110 92 104 61 73 64 87 83 96 74 63 24 15 12 15 25 20 45 29 19 17 76 77 61 59 72 47 49 64 59 36 46 45 23 17 17 38 46 33 16 13 49 43 100 50 136 138 150 18 28 15 13 Total Number 200 0 2,000 2,001 2,002 2,003 Unintentional 2,004 2,005 Self Harm 2,006 2,007 Undetermined 2,008 2,009 2,010 2,011 No Ecode Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 28 2,012 Medicaid Recipient Total Opiate Overdose Inpatient Hospitalization Charges, 2008‐2012 $12 $11.4 $11.1 $10 $8 Dollars (in millions) Total Charges $6.7 Operating Room Charges Other Charges $6 Oncology Charges $5.6 Pharmacy Charges Radiology Charges Room & Board Charges Labor & Delivery Charges $4.1 Anesthesia Charges $4 Ancillary Charges $2 $0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 29 Medicaid Recipient Opiate Overdose Emergency Department Visits by Gender, 2008‐2012 146 160 101 77 89 94 100 63 71 80 60 Male 53 Total Number 120 108 114 140 Female 40 20 0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Medicaid Recipient Opiate Overdose Emergency Department Visits by Intent, 2008‐2012 136 160 140 101 120 12 27 35 40 55 56 71 73 52 38 36 8 7 7 20 7 40 33 60 68 80 54 Total Number 100 0 2008 2009 Unintentional 2010 Self Harm Undetermined 2011 2012 No Ecode Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 30 Medicaid Recipient Opiate Overdose Total Emergency Department Charges, 2008‐2012 $900 $800 $740 $700 $584 Dollars (in thousands) $600 $472 $500 $405 $400 $306 $300 $200 $100 $0 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 31 Opioid‐Related Disease Condi on Hospitaliza ons 2000‐2012 32 Kentucky Resident Opioid‐Related Disease Condition Hospitalizations, 2000‐2012 9,000 8,465 7,891 8,000 7,389 6,909 7,000 6,400 Total Number 6,000 5,464 5,725 4,677 5,000 4,385 4,000 3,142 3,357 3,860 3,000 2,209 2,000 1,000 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Note: 6.7% of all opioid‐related disease condi on hospitaliza ons listed also an ICD‐9‐CM code for drug overdose 2008 5,757 5,572 5,220 4,578 4,356 2007 2010 2011 2,005 1,850 2006 1,771 2005 1,661 890 2004 1,358 828 2003 1,193 787 2002 1,158 2,707 658 2001 2,000 1,124 3,564 2,673 481 2000 3,000 1,000 3,083 4,000 3,795 5,000 361 Total Number 6,000 6,147 7,000 6,491 Kentucky Resident Opioid‐Related Disease Condition Hospitalizations by Condition Type, 2000‐2012 0 Nondependent opioid abuse 2009 Opioid type drug dependence Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Note: 0.3% of all opioid‐related disease condi on hospitaliza ons listed both condi on types 33 2012 4,610 Kentucky Resident Opioid‐Related Disease Condition Hospitalizations by Gender, 2000‐2012 1,216 993 2,000 1,500 2001 2002 3,855 3,711 3,678 3,231 3,168 2,890 2,835 2,770 2,694 2,241 2,144 1,793 1,564 2,500 2,013 1,847 3,000 2,355 2,322 3,500 1,718 1,424 Total Number 4,000 3,430 3,479 4,500 3,803 4,088 5,000 Male Female 1,000 500 0 2000 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Kentucky Resident Opioid‐Related Disease Condition Hospitalization Charges, 2000‐2012 $180.0 $166.6 $160.0 $144.1 Dollars (in millions) $140.0 $122.1 $120.0 $104.0 $100.0 $84.5 $80.0 $62.1 $60.0 $48.6 $40.0 $21.6 $20.0 $66.1 $27.7 $34.7 2002 2003 $41.6 $13.9 $0.0 2000 2001 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 34 Kentucky Resident Opioid‐Related Disease Condition Hospitalization Charges by Expected Payer, 2000‐2012 $45.9 $2.9 2012 $39.6 $55.4 $22.8 $41.4 $1.2 2011 $31.3 $49.3 $20.8 $37.3 $2.0 2010 $23.7 $41.4 $17.7 $30.3 $1.4 2009 $21.7 $36.9 $13.8 $20.5 $17.0 $17.3 $2.7 2008 $15.0 $13.2 $6.3 2007 $22.7 $8.8 $6.9 2006 $12.7 $12.8 $10.3 $10.0 $8.2 $9.8 $5.6 2005 $8.7 $5.5 $7.8 $5.2 2004 $27.0 $19.4 $15.0 Self Pay or Charity $14.4 Other Medicare $6.0 $3.5 $6.8 $10.8 $7.5 2003 $3.8 $2.2 $5.2 2002 Medicaid Commercial $8.3 $8.3 $3.3 $2.3 $4.2 $6.7 $5.2 $1.2 $1.0 $2.5 $5.0 $4.1 2001 2000 $0.0 $10.0 $20.0 $30.0 $40.0 $50.0 $60.0 Dollars (in millions) Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 35 $70.0 Kentucky Resident Hospitalizations Involving Opioid Drug Overdose or an Opioid‐Related Disease Condition AND Viral Hepatitis, 2000‐2012 2012 144 2011 2004 65 43 2003 59 34 35 20 2001 29 20 2000 24 8 0 277 89 33 2002 Year 394 113 56 2005 435 108 45 2006 545 135 53 2007 633 157 85 2008 702 208 85 2009 976 293 114 2010 1,192 378 210 Opioid type drug dependence & Viral hepatitis 203 Nondependent opioid abuse & Viral hepatitis 138 Drug overdoses due to the effect of opiates and related narcotics &Viral hepatitis 118 72 200 400 600 800 1,000 1,200 Total Number Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky Outpatient Services Database, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 36 Neonatal Abs nence Syndrome Hospitaliza ons 2000‐2012 37 Kentucky Resident Neonatal Abstinence Syndrome Hospitalizations, 2000‐2012 900 824 800 678 700 Total Number 600 485 500 435 400 329 275 300 227 200 100 28 62 93 128 2002 2003 166 175 0 2000 2001 2004 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. Kentucky Resident Neonatal Abstinence Syndrome Hospitalization Charges, 2000‐2012 $45.0 $40.2 $40.0 $36.0 $35.0 Dollars (in millions) $30.0 $23.8 $25.0 $25.0 $20.0 $15.0 $15.0 $10.0 $7.5 $5.0 $0.2 $1.5 $1.3 $2.4 $3.2 2001 2002 2003 2004 $4.0 $5.2 $0.0 2000 2005 2006 2007 2008 2009 2010 2011 2012 Produced by the Kentucky Injury Prevention and Research Center, January 2014. Data source: Kentucky inpatient hospitalization discharge data, Office of Health Policy. Data for 2010‐2012 are provisional and subject to change. 38 Kentucky Resident Neonatal Abstinence Syndrome Hospitalizations by Expected Payer, 2000‐2012 Self‐Pay or Commercial Medicaid Other Charity 2000 5 20 <5 <5 2001 16 41 <5 <5 2002 11 67 8 7 2003 21 99 <5 <5 2004 14 139 <5 9 2005 12 147 7 9 Year 2006 11 202 9 5 2007 23 224 16 12 2008 37 270 18 <5 2009 38 355 40 <5 2010 42 402 35 6 2011 90 526 55 7 2012 59 694 54 17 Note: Counts less than 5 were suppressed by state data management policy. Kentucky Resident Neonatal Abstinence Syndrome Hospitalization Charges by Expected Payer, 2000‐2012 Self‐Pay or Commercial Medicaid Other Total Charity 2000 $75,463 $155,642 $4,318 $1,074 $235,423 2001 $989,491 $464,827 $11,180 $20,927 $1,465,498 2002 $181,443 $932,251 $24,374 $113,947 $1,138,068 2003 $685,212 $1,597,333 $9,166 $145,842 $2,291,710 2004 $262,538 $2,731,983 $50,125 $189,625 $3,044,646 2005 $471,640 $3,201,153 $46,089 $276,770 $3,718,883 2006 $161,693 $4,802,755 $138,686 $134,258 $5,103,135 Year 2007 $697,463 $6,001,220 $414,598 $355,295 $7,113,281 2008 $2,700,471 $11,503,166 $685,389 $96,154 $14,889,026 2009 $3,142,217 $19,266,407 $1,198,435 $227,639 $23,607,058 2010 $2,156,244 $21,052,317 $1,231,209 $580,403 $24,439,769 2011 $6,360,864 $28,130,564 $1,267,251 $232,167 $35,758,679 2012 $3,287,661 $34,876,300 $1,606,756 $476,472 $39,770,716 39 APPENDIX A ICD‐9‐CM codes for acute poisonings due to the effects of drugs (drug overdoses) ICD‐9‐CM codes Type of Poison DRUG E850‐E585, E950(.0‐.5), E962.0, E980(.0‐.5), 960‐979 E850(.3‐.8), 965(.1‐.8) ‐Nonopioid analgesics, Antipyretics, and Antirheumatics ‐‐4‐Aminophenol derivatives E850.4, 965.4 ‐Opiates/opioids E850(.0‐.2), 965.0 ‐‐Heroin E850.0, 965.01 ‐‐Pharmaceutical Opioids E850(.1‐.2), 965(.00,.02‐.09) ‐‐‐Methadone E850.1,965.02 ‐Cocaine E854.3, E855.2, 968.5, 970.81 E851‐E853, E854(.0‐.2,.8), E855.0, E950(.1‐.3), E980(.1‐.3), 966, 967, 969, 970(.0,.1,.89) ‐Antidepressants, barbiturates and other antiepileptics, sedative‐hypnotics, and psychotropic drugs not elsewhere classified ‐‐Benzodiazepines E853.2, 969.4 ‐‐Psychostimulants with abuse potential including methamphetamine, MDMA (Ecstasy) E854.2, 969.7 ‐Anticoagulants 964.2 ‐Other specified and unspecified drugs E850(.9), E855(.1,.3‐.9), E856‐E858, E950(.0,.4,.5), E962.0, E980(.0,.4,.5), 960‐963, 964(.0,.1,.3‐.9), 965.9, 968(.0‐.4,.6‐.9), 970(.9),971‐979, For more informa on, please refer to: Consensus Recommenda ons for Na onal and State Poisoning Surveillance, Safe States, April 2012. 40 Conclusions The combina on of mul ple preven on approaches such as mandatory enrollment and use of the Kentucky All Schedule Prescrip on Electronic Repor ng system by prescribers and dispensers, physician ownership of pain clinics, prescriber guidelines for pain treatment, and increased law enforcement resulted in substan al decreases in Kentucky resident prescrip on drug overdose deaths, inpa ent hospitaliza ons, and ED admissions from 2011 to 2012. With that said, pharmaceu cal opioids remained the primary drugs involved in drug overdose deaths; benzodiazepines were the primary drugs involved in drug overdose‐related inpa ent hospitaliza‐ ons and ED visits. Pharmaceu cal opioid involvement decreased 12% for drug overdose deaths, 8% for in‐ pa ent hospitaliza ons, and 6% for ED visits from 2011‐2012. Correspondingly, benzodiazepine involve‐ ment decreased 16% for drug overdose deaths, 11% for inpa ent hospitaliza ons, and 9% for ED visits from 2011‐2012. Raising awareness of the dangers of mixing benzodiazepines with opioids should be an empha‐ sis of physician con nuing educa on for relaying to opioid pa ents during medical consulta ons. While the contribu on of prescrip on opioids and benzodiazepines to drug overdoses decreased from 2011 to 2012, there was a precipitous increase in heroin involvement in drug overdose deaths, inpa‐ ent hospitaliza ons, and ED visits over the same me period. Heroin involvement increased 207% for drug overdose deaths, 174% for inpa ent hospitaliza ons, and 197% for ED visits. Opioid‐related hospitaliza ons and ED visits are costly in more than only financial erms. Disease condi ons already present or those caused by opiate addic on such as viral hepa s also exert an enormous societal as well as financial toll on the commonwealth’s popula on. Increased law enforcement, adjudica on, legisla on, and heroin abuse treat‐ ment should be a major priority for Kentucky to reduce heroin‐related deaths, and hospitaliza ons. Total inpa ent hospitaliza on charges for drug overdoses rose 7% in 2012 to $129.3 million. Like‐ wise, drug overdose ED charges rose 5% to $15.3 million in 2012. The primary expected payers for drug overdose related inpa ent hospitaliza ons were Medicare ($41.3 million) and Medicaid ($34.1 million). Self ‐pays were the largest expected payer for drug overdose ED visits ($5 million) followed by Medicaid ($4.2 million). Medicaid recipient opiate overdose ED charges increased 27% in 2012 to $740,000. Inpa ent hospi‐ taliza ons of Medicaid recipients for opiate overdoses leveled off in 2012 at $11 million. Elevated Medicaid charges illustrate the need for naloxone (an opiate an dote) reimbursement by Medicaid so that Medicaid recipients are not charged for its purchase. Intranasal administra on of naloxone during an opiate overdose has been credited with saving countless lives. A mul pronged strategy to reduce substance abuse in the Commonwealth of Kentucky involves the basic elements of the public health model that includes comprehensive surveillance and tracking of drug overdoses, iden fica on of the risk factors that result in drug overdoses, development of interven ons to prevent drug overdoses, and the widespread adop on of substance abuse preven on interven ons. In ad‐ di on, increased con nuing educa on of physicians on drug abuse and treatment, increased law enforce‐ ment, increased adjudica on, and increased substance abuse treatment facili es are necessary to decrease the extraordinary toll of substance abuse on Kentucky ci zens who are addicted. 41 About This Report This report presents drug overdose morbidity and mortality data for Kentucky residents, using mul ple data sources: ‐ Kentucky Death Cer ficate Files, Kentucky Office of Vital Sta s cs, 2000‐2012 (data captured as of October 21, 2013). The 2009‐2012 files are provisional and subject to change. ‐ Kentucky Inpa ent Hospitaliza on (IH) Discharge Files, Cabinet for Health and Family Services, Office of Health Policy, 2000‐2012 (data for 2010‐2012 are provisional and subject to change). ‐ Kentucky Emergency Department (ED) Discharge Files, Cabinet for Health and Family Services, Office of Health Policy, 2008‐2012 (data for 2010‐2012 are provisional and subject to change). Drug overdose mortality and morbidity case selec on was based on opera onal defini ons of acute drug poisoning (also called “drug overdose”) by the Injury Surveillance Workgroup on Poisoning (ISW7) in their Consensus RecommendaƟons for NaƟonal and State Poisoning Surveillance, The Safe States Alliance, Atlanta, GA, April 2012.1 Drug Overdose Deaths: Each death cer ficate contains one underlying cause of death and mul ple contribu ng causes of death. The underlying cause of death is defined as the reason that ini ated the chain of events leading di‐ rectly to death. The underlying and contribu ng causes of death are coded according to the Interna onal Classifica on of Diseases, 10th revision (ICD‐10) [www.who.int/classifica ons/icd10/]. Defini on: Drug overdose deaths were iden fied as deaths with an underlying cause of death in the follow‐ ing range: X40‐X44(accidental/uninten onal drug poisoning), X60‐X64(suicide by drug poisoning), X85 (homicide by drug poisoning), and Y10‐Y14 (drug poisoning with undetermined intent). The types of drugs contribu ng to drug overdose deaths were iden fied using ICD‐10 codes T36‐ T50.9 listed in any of the mul ple causes of death fields. Contribu ng drugs were reported in standardized categories, following the ISW7 Poisoning Matrix for ICD‐10 Coded Mortality Data.1 Drug Overdose Hospitaliza ons and ED Visits : IH and ED data were coded according to the Interna onal Classifica on of Disease, 9th revision, Clini‐ cal Modifica on (ICD‐9‐CM, www.icd9cm.chrisendres.com). The ICD‐9‐CM system describes an injury using diagnosis codes and E‐codes. The Kentucky IH and ED data systems include up to 25 diagnosis code fields per case. The first diagnosis code is called the principal diagnosis code. The principal diagnosis for a hospitalized pa ent is the main reason for the pa ent’s hospital stay and is based on the clinical findings during the pa‐ ent’s stay. For ED data, the primary diagnosis code is the diagnosis established to be the main reason for the visit to the emergency department. Other condi ons/diagnoses that exist at the me of the IH/ED visit and affect the diagnosis, treatment, or length of stay in the health facility, are also coded in the remaining 24 diagnosis code fields in the IH/ED datasets and are called secondary diagnoses. Injury diagnoses should be supplemented (when circumstances of the injury are known) with addi onal codes called E‐codes. E‐codes are separated into three groups: external‐cause‐of‐injury codes, place‐of‐injury codes, and ac vity codes. 42 The external‐cause‐of‐injury code describes the external cause (in this case, poisoning) and the in‐ tent of injury. Based on the external‐cause‐of‐injury code, a drug poisoning can be classified by intent as accidental (uninten onal, E850‐E858), inten onal (self‐harm, E950.0‐E950.5; or assault, E962.0), or unde‐ termined (E980.0‐E980.5 when based on insufficient documenta on in the medical chart to determine whether the drug overdose was accidental or inten onal). Some injury records in the IH or ED datasets, however, are not supplemented with E‐codes at all. We treat such records as a separate category and refer to them as “missing intent” or “no E‐code”. IH and ED electronic records may contain up to three designat‐ ed E‐code fields. On average, more than 90 percent of the Kentucky HD and ED cases with poisoning diag‐ noses are supplemented with valid external‐cause‐of‐injury codes. Defini on: A hospitaliza on or emergency department visit was considered a drug overdose if 1) any of the ICD‐9‐CM codes in the range 960‐979 were listed in any diagnosis (principal or secondary) fields; or 2) any of the ICD‐9‐CM codes in the range E850‐E858, E950.0‐E950.5, E962.0, or E980.0‐E980.5 were listed in the E‐code fields. This Injury Surveillance Workgroup on Poisoning1 defini on is a broader defini on than the defini‐ on used in the 2012 report2 on drug overdose morbidity and mortality in Kentucky. Therefore, if compar‐ ing the morbidity sec ons in the current and in the 2012 report, one will no ce about a 30% increase in the reported cases of drug overdose hospitaliza ons or ED visits. The 2012 report was based on defini ons de‐ rived from the external‐cause‐of‐injury matrix and didn’t capture encounters of care where the principal diagnosis was not a drug overdose but the secondary diagnosis was drug overdose. A study on drug over‐ dose ED visits in the U.S. suggested that mild or moderate drug overdoses were likely to have the drug poisoning as their primary diagnosis but severe drug poisoning cases were likely to have a cri cal illness as the primary diagnosis.3 Severe drug overdoses can result in acute respiratory, heart, or renal failure that may be listed as principal diagnoses with a drug overdose listed as the secondary diagnosis. As the state enacts policies and plans for adequate substance abuse treatment resources, the most comprehensive defi‐ ni on to track and enumerate total drug overdose hospitaliza ons and ED visits was used to provide a more accurate picture of the magnitude of substance abuse and misuse, the specific drugs involved, and the specific popula ons at higher risk for drug overdoses. Only records for KY residents treated in Kentucky acute care hospitals or Kentucky emergency de‐ partments are included in this report. Data for Kentucky residents treated in neighboring states were not available and not included in this report. Therefore, the presented counts and rates likely underes mate the full extent of drug overdoses in Kentucky. Reported frequencies reflect the number of visits/ hospitaliza ons since follow‐up visits and readmissions for one and the same drug overdose could not be iden fied. Age‐adjusted morbidity and mortality rates were based on 2000 U.S. standard popula on data. For each of the three data sets, the number of cases classified as assault was low (48 ED visits from 2008 – 2012, 35 hospitaliza ons from 2000 –2012 and seven fatali es from 2000 –2012) and were not included in the figures or discussed in this report. A sec on on mental disorder hospitaliza ons involving opiates/opioids was included in the report in order to describe disease condi ons induced by opium, heroin, and/or opioid analgesics. The case selec on followed the ISW71 framework and included hospitaliza ons related to opioid type dependence, drug de‐ pendence on combina ons of opioid type drugs with any other, or nondependent opioid abuse, iden fied by any of the following ICD‐9‐CM codes in any of the diagnosis fields: 304 (.00‐.02, .70‐.72), 305 (.50‐.52). 43 In the hospital discharge dataset, drug overdoses due to the effect of opiates and related narco cs were iden fied as records with any of the ICD‐9‐CM code 965(.00‐.09) in any of the diagnosis fields. Viral hepa s cases we iden fied by ICD‐9‐CM code 070 in any of the diagnosis fields. Neonatal Abs nence Syndrome (NAS) is a drug withdrawal syndrome in a newborn that is caused by the mother’s drug abuse during pregnancy. Hospitaliza ons involving drug withdrawal syndrome in a new‐ born are iden fied by the ICD‐9‐CM code 779.5 listed in any of the diagnosis fields. A sec on on NAS hospi‐ taliza ons was added to this report to describe another aspect and burden of drug abuse and addic on in the Commonwealth. References: 1. Consensus Recommenda ons for Na onal and State Poisoning Surveillance, The Safe States Alliance, At‐ lanta, GA, April 2012. 2. Bunn TL, Slavova S, Drug Overdose Morbidity and Mortality in Kentucky, 2000‐2010, KIPRC, 2012. 3. Xiang Y, Zhao W, Xiang H, Smith GA. ED Visits for Drug‐related Poisoning in the United States, 2007. Am J Emerg Med. 2012 Feb: 30(2):293‐301. 44