UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
DISODIUM HYDROGEN PHOSPHATE
Table of Contents
Valid for:
2 years from approval
Page
1. Chemical Product
2. Composition and Information on Ingredients
3. Hazards Identification
4. First Aid Measures
5. Fire and Explosion Data
6. Accidental Release Measures
7. Handling and Storage
8. Exposure Controls/ Personal Protection
9. Physical and Chemical Properties
10. Stability and Reactivity Data
11. Toxicological Information
12. Ecological Information
13. Disposal Considerations
14. References
15. Appendices
16. Revision History
Page 1 of 9 Ref. No.
MSDS /PD/17_01
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UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Chemical Product
1.
Product Name: Disodium hydrogen phosphate
Chemical name: Phosphoric Acid, disodium salt, dodecahydrate
Synonyms: Sodium monohydrogen phosphate dodecahydrate; Monosodium Phosphate
dodecahyddrate; Disodium hydrogen orthophosphate dodecahydrate; Disodium hydrogen
phosphate dodecahydrate; Disodium
monohydrogen phosphate dodecahydrate
Chemical Formula: Na2HPO4.12H2O
2.
Composition and Information on Ingredients
Composition: Disodium hydrogen phosphate 100% by weight
Toxicological Data on Ingredients: Not applicable
3.
Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant,
permeator), eye contact (irritant), ingestion and inhalation.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: N/A
MUTAGENIC EFFECTS: N/A
TERATOGENIC EFFECTS: N/A
DEVELOPMENTAL TOXICITY: N/A. Repeated or prolonged exposure is not known to aggravate
medical condition.
Page 2 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
4.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
First Aid Measures
General measures: N/A
Skin contact: Wash with soap and water and cover the irritated skin with an emollient. Get
medical attention if irritation develops. Cold water may be used.
Serious skin contact: N/A
Eye contact: Check for and remove any contact lenses. In case of contact, immediately flush
eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical
attention if irritation occurs.
Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never
give anything by mouth to an unconscious person. If large quantities of this material are
swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or
waistband.
Serious indigestion: N/A
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention.
Serious inhalation: N/A
Page 3 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
5.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Fire and Explosion Data
Flammability of the Product: Non-flammable
Auto-Ignition Temperature: Not applicable
Flash points: Not applicable
Flammable limits: Not applicable
Products of Combustion: N/A
Fire Hazards in Presence of Various Substances: Not applicable Explosion Hazards in Presence of Various Substances:
− Risks of explosion of the product in presence of mechanical impact: N/A
− Risks of explosion of the product in presence of static discharge: N/A
Fire fighting media and Instructions: Not applicable
Special Remarks on Fire Hazards: N/A
Special Remarks on Explosion Hazards: N/A
Page 4 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
6.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Accidental Release Measures
NB: Wear appropriate protective equipment/clothing including gloves before removing
any spills.
Small spill: Use appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and dispose of
according to local and regional authority requirements.
Large spill: If the product is in its solid form: Use a shovel to put the material into a
convenient waste disposal container. If the product is in its liquid form: Absorb with an inert
material and put the spilled material in an appropriate waste disposal. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the sanitary
system.
7.
Handling and Storage
Precautions: Do not breathe dust. Keep away from incompatibles such as oxidizing agents,
acids, alkalis
Storage: Keep container tightly closed in a cool, well-ventilated area
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: N/A
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering
controls to keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below
the exposure limit.
Personal Protection: Safety glasses, gloves, lab coat, dust respirator, making sure to use an
approved/certified respirator or equivalent.
Page 5 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
9.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Physical and Chemical Properties
Physical state and appearance: White solid. (Crystals solid. Granular solid. Translucent
solid.)
Odour: Odourless
Taste: N/A
Molecular Weight: 358.2 g/mole
pH (1% solution/water): 9.5 [Basic.]
Boiling Point: N/A
Melting Point: 34°C (93.2°F) - 35 °C
Critical Temperature: N/A
Specific Gravity (Water = 1): 1.5
Vapour Pressure (mmHg): Not applicable
Vapour Density: N/A
Volatility: N/A
Odour Threshold: N/A
Water/Oil Distribution Coefficient: N/A
Ionicity (in Water): N/A
Dispersion Properties: See solubility in water
Solubility: Easily soluble in cold water, hot water. Soluble in 3 parts water. Solubility in
water: 87.4 g/100 ml water @ 34 oC Insoluble in alcohol.
Stability and Reactivity Data
10.
Stability: The product is stable
Corrosivity: Non-corrosive in presence of glass
Instability temperature: N/A
Conditions of Instability: Incompatible materials
Incompatibles: Reactive with oxidizing agents, acids, alkalis. Loses 12 H2O @ 100 deg. C.
Loses 5 moles of water on exposure to air at ordinary temperature. Incompatible with
magnesium, alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol, strong
mineral acids, strong organic acids.
Polymerization: Will not occur
Page 6 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
11.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Toxicological Information
Toxicity to animals: LD50: N/A. LC50: N/A. Lethal Dose/Conc 50% Kill: LD50 [Mouse] Route: Intraperitoneal; Dose: 430 mg/kg
Effects on humans:
Acute potential health effects:
− Skin: Causes mild skin irritation. May cause dermatitis.
− Eyes: Causes mild eye irritation.
− Ingestion: May cause irritation of the digestive tract and may cause purging. It is
slowly absorbed. Expected to be a low ingestion hazard for usual industrial handling.
Ingestion of large doses may affect behaviour/central nervous system (tetany).
However, if a significant amount of phosphate is absorbed, hypophosphataemia will
occur. Severe hypophosphataemia may result in hypocalcemia and tetany.
Cardiovascular, respiratory, neurologic, and musculoskeletal effects may occur
secondary to hypernatraemia, hypophosphataemia, and hypocalcaemia.
− Inhalation: May cause respiratory tract and mucous membrane irritation. Low hazard
for usual industrial handling.
Chronic potential health effects:
− Skin: High and repeated exposure may cause dermatitis
MUTAGENIC EFFECTS: N/A
TERATOGENIC EFFECTS: N/A
DEVELOPMENTAL TOXICITY: N/A
Other information: Slightly hazardous in case of skin contact (irritant, permeator), ingestion
and inhalation.
12.
Ecological Information
Ecotoxicity: N/A Page 7 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
13.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Disposal Considerations
Waste Disposal: Waste must be disposed of in accordance with local environmental control
regulations.
14.
References
− Sciencelab.com. Material Safety Data Sheet; Disodium hydrogen phosphate, MSDS
[Online]
2005
[cited
2012
Oct
31].
Available
from:
URL:
http://www.sciencelab.com/msds.php?msdsId=9925027
− Ch.ntu.edu.tw. Material Safety Data Sheet; Disodium hydrogen phosphate, MSDS
[Online]
2012
[cited
2012
Oct
31].
Available
from:
URL:
http://www.ch.ntu.edu.tw/~genchem99/msds/exp9/Na2HPO4.pdf
− Cleartech.ca. Material Safety Data Sheet; Disodium hydrogen phosphate, MSDS
[Online]
2012
[cited
2012
Oct
31].
Available
from:
URL:
http://www.cleartech.ca/msds/disodiumphos.pdf
15.
Appendices
N/A Page 8 of 9 UNIVERSITY OF MALTA
FACULTY OF MEDICINE & SURGERY
PHARMACY DEPARTMENT
MATERIAL SAFETY
DATA SHEET
16.
DISODIUM HYDROGEN PHOSPHATE
Ref. No.
MSDS /PD/17_01
Valid for:
2 years from approval
Revision History
Version Number Amendments/ Reasons for change
01
Initial Release
Page 9 of 9