Course Catalogue Year 2009-2010
8/18/2010
THIRD YEAR
INTAKE 2008
ACADEMIC YEAR 2010/11
62
Course Catalogue Year 2009-2010
UNITCODE:
PHR 3106*
8/18/2010
UNIT TITLE:
PHARMACY PRACTICE III
TYPE
Lectures, seminars, practicals and tutorials, placement
NUMBER OF ECTS CREDITS: 12
LEARNING OBJECTIVES
To provide students with examples of knowledge required to practice disease management.
To reinforce amongst students an awareness that they are to become members of a
prestigious profession and to develop further within them a professional attitude, a sense of
responsibility and a comprehensive knowledge of the requirements for an efficient and
accurate pharmaceutical service. Opportunities are given for the students to interact with
patients, to assess and identify a problem and to give advice to patients.
Practical experience in community pharmacy and in practical settings of pharmacy.
CONTENT
Designing and Recommending a Pharmacist’s Care Plan
Pharmacist Prescribing
Quality Standards in pharmacy practice
Cardiovascular Disorders:
Testing for Cardiovascular Disorders, Hypertension, Hyperlipidemia, Congestive Heart
Failure, Ischaemic Heart Disease, Thrombosis
Dispensing Drugs acting on the Autonomic Nervous System:
Cholinergic Drugs & Cholinergic Blocking agents
Adrenergic and Adrenergic Blocking agents
Skin Disorders:
Allergy and drug-induced skin disease
Acne and Psoriasis
Histamine and Antihistamine drugs
Dementia and Alzheimer’s Disease
Psychiatric Disorders:
Schizophrenia, Mood disorders, Anxiety disorders, Sleep disorders, Obesity and Eating
disorders
Obstetrics, Gynaecology and Genito-urinary Disorders:
Hormone Replacement Therapy, Menstrual disorders, Contraception and infertility
problems, Drugs for genito-urinary disorders
Infectious diseases:
HIV, Hepatitis
Medication Errors
Pharmacy Practice Research: Observational Methods, Surveys, Questionnaire construction
Qualitative research, Secondary data analysis, Data preparation, Statistical methods,
Practical experience in a community pharmacy and practical attachment
Participation at the yearly symposium.
ASSESSMENT
Assessment is aimed to evaluate students’ knowledge and understanding of topics that form
the core of knowledge required for effective professional practice.
Written test (Duration of 2 hours) 95%
14 compulsory short questions (5 marks each)
3 questions (10 marks each)
No marks will be allocated to partially correct answers.
Held at the end of the second semester.
Log Book 5%. The marks obtained from all practical sessions presented will be
considered for the assessment. +
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Course Catalogue Year 2009-2010
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RESULT
Percentage mark and grade
LECTURERS/DEMONSTRATORS
Lilian M. Azzopardi (Co-ordinator)
Michael Calleja
Conrad Buttigieg Scicluna
Louise Azzopardi
Anthony Serracino Inglott
Daniel Calleja
Clifton Curmi
Alison Anastasi
GENERAL BIBLIOGRAPHY FOR PHARMACY PRACTICE MODULE
Azzopardi L (ed). Lecture notes in pharmacy practice. 2009. London: Pharmaceutical
Press
The British National Formulary. Pharmaceutical Press: London. latest edn.
Medical Dictionary
Martindale, W. The Extra Pharmacopoeia,. Pharmaceutical Press: UK
ASHP. Medication Teaching Manual: The Guide to Patient Information. Bethesda:
ASHP. latest edn
British Medical Association and Royal Pharmaceutical Society of Great Britain. British
National Formulary. London, recent edn.
Monthly Index of Medical Specialties (MIMS) Haymarket Medical Ltd: London
(latest edn)
Royal Pharmaceutical Society of Great Britain. Medicines, ethics and practice - a guide
for pharmacists. RPSGB: London. latest ed.
Code of Ethics, Pharmacy Board, Malta.
ABPI: Data Sheet Compendium, Walker G. Datapharm Publication: UK (latest ed.)
READING LIST
Randall MD, Neil KE. Disease management: A Guide to Clinical Pharmacology.
2009. London: Pharmaceutical Press.
Walker, R, Whittlesea C. Clinical pharmacy and therapeutics. 2007. Edinburgh: Churchill
Livingstone.
Greene, RJ, Harris, N. Pathology and therapeutics for pharmacists. A Basis for Clinical
Pharmacy Practice. 2008. London: Pharmaceutical Press.
Wright J, Gray A. Clinical Pharmacy Pocket companion. 2006 London: Pharmaceutical
Press.
Shankie S. Hypertension in focus. 2001.London: Pharmaceutical Press.
Cipolle, RJ, Strand, LM, Morley PC. Pharmaceutical care practice. 1998. USA: McGrawHill.
Azzopardi, L. Validation instruments for community pharmacy: Pharmaceutical care for
the third millennium. 2000. Birminghamton, USA: Pharmaceutical Products Press.
McKay, AB, Hepler, CD, Knapp, DA. How to evaluate progressive pharmaceutical
services. 1987. Bethesda: ASHP.
Brown, TR. ed. Handbook of institutional pharmacy practice. 1992.
Bethesda: ASHP.
Sexton J, Nickless G, Green C. Pharmaceutical care made easy: Essentials of Medicines
Management in the Individual Patient. 2006. London: Pharmaceutical Press.
Taylor D. Schizophrenia in Focus. 2006. London: Pharmaceutical Press.
Koda-Kimble M.A, Young LY, Kradjan WA. Handbook of Applied Therapeutics. 2006.
USA: Lippincott Williams & Wilkins
+ Refer to Guidelines for Community Pharmacy Practice
* Pre-requisites: PHR 1101 and PHR 2103.
64
Course Catalogue Year 2009-2010
UNITCODE:
PHR 3108
8/18/2010
PHARMACOTHERAPEUTICS
UNIT TITLE:
TYPE
Lectures, practicals and seminars
NUMBER OF ECTS CREDITS: 4
LEARNING OBJECTIVES
To provide information on the aetiology, clinical signs and symptoms, investigations and
principles of treatment of diseases important to pharmacists in their development of a
patient-oriented practice. Particular emphasis is given to the selection of appropriate drug
treatment regimens, a balance of benefits to risks for patients under treatment and patient
monitoring. Problem solving is carried out using case studies.
To enable the student to extract relevant information from clinical case notes and to identify
and discuss pharmaceutical care issues.
CONTENT
Clinical investigations:
Renal function tests, liver function tests, blood tests
Serum electrolytes, acid base balance, cardiac enzymes, electrocardiograms
Therapeutic principles of selected disease states:
Respiratory disorders: asthma, chronic obstructive airways disease
Cardiovascular disorders: hypertension, angina, myocardial infarction, cardiac failure,
atrial fibrillation, stroke
GI disorders: peptic ulceration, Crohn’s disease, ulcerative colitis
Clinical case studies on the ward:
Understanding case notes, medical terminology, medical abbreviations, patient profiling,
case presentation format
Familiarization with clinical case notes of a selected patient and compilation of patient
profile
Interaction with multidisciplinary health care team and patients during ward round
Oral presentation of clinical case study
ASSESSMENT
Written test of 2 hours:
Case presentation
80%
20%
RESULT
Percentage mark and grade
LECTURERS/DEMONSTRATORS
Lilian M. Azzopardi (Co-ordinator)
Marise Gauci
Aaron Camilleri
Simone Caruana
Ian Mifsud
Angelo Psaila
Anthony Serracino Inglott
Lilian Wismayer
Kristen Buhagiar
Roberta Messina
Emma Manduca
Elaine Vella
READING LIST
Walker R, Whittlesea C. Clinical pharmacy and therapeutics. 2007. Edinburgh :
Churchill Livingstone
Greene RJ, Harris N. Pathology and therapeutics for pharmacists. 2008. London :
Pharmaceutical Press.
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Course Catalogue Year 2009-2010
8/18/2010
Young LY, Koda-Kimble MA. Handbook of applied therapeutics. Lippincott Williams &
Wilkins.
Dodds L. Drugs in use. 2003. London: The Pharmaceutical Press.
Koda-Kimble M.A, Young LY, Kradjan WA. Handbook of Applied Therapeutics. 2006.
USA: Lippincott Williams & Wilkins
66
Course Catalogue Year 2009-2010
UNIIT CODE:
PHR 3115*
8/18/2010
PHARMACY PRACTICE
PROJECT II
UNIT TITLE:
TYPE
Project
NUMBER OF ECTS CREDITS: 6
LEARNING OBJECTIVES
This unit introduces the student to research methodology, applying the knowledge from
previous units with special reference to planning, selection of data and following a protocol
CONTENT
Protocol feasibility, discussion and approval
Starting of field work
ASSESSMENT
Protocol
Poster presentation
Participation at project presentations
50%
30%
20%
RESULT
Percentage mark and grade
LECTURERS
Anthony Serracino Inglott (Co-ordinator)
Lilian M. Azzopardi
Claire Shoemake
Maurice Zarb Adami
READING LIST
Stuart MC. The complete guide to medical writing. 2007 London: Pharmaceutical Press.
Frankfort-Nachmias C., Nachmias D. ed. Research Methods in the Social Sciences.
London: Edward Arnold. 1992.
Pink, A. The Survey Kit. Thousand Oaks: Sage Publications. 1995.
Knapp, T.R. Qantitative Nursing Research, Thousand Oaks: Sage Publications. 1995.
Patton, M.Q. Qualitative evaluation and research methods. Thousand Oaks: Sage
Publications. 1990.
Smith F. Research methods in pharmacy practice. 2002. London: Pharmaceutical
Press.
Jones DS. Pharmaceutical statistics. 2002. London: Pharmaceutical Press.
Smith F. J. Conducting your Pharmacy Practice Research Project. 2005. London:
Pharmaceutical Press.
Smith F, Francis SA, Schafheutle E. International Research in Health Care. 2008.
London: Pharmaceutical Press.
Durham TA, Turner JR. Introduction to Statistics in Pharmaceutical Clinical Trials. 2008.
London: Pharmaceutical Press.
* Pre-requisite: PHR 2018.
67
Course Catalogue Year 2009-2010
UNITCODE:
PHR 3205*
8/18/2010
UNIT TITLE:
PHARMACEUTICAL ANALYSIS
AND MEDICINAL CHEMISTRY II
TYPE
Lectures and seminars
NUMBER OF ECTS CREDITS: 6
LEARNING OBJECTIVES
To review legislative aspects behind the running of analytical laboratories.
To introduce further principles applied to drug design in various drug classes.
CONTENT
This Unit will deal with the Medicinal Chemistry (including the Structure – Activity
relationships (SAR) of:
Tricyclic and related psychotherapeutic drugs; atypical antipsychotics; pro-drug approach to
depot antipsychotics.
Monoamine Oxidase Inhibitors (MAOIs) and reversible MAOIs; Selective Serotonin reuptake
inhibitors (SSRIs) and other antidepressants.
Benzodiazepines and the first benzodiazepine competitive antagonist. Buspirone, zolpidem.
Antibacterial drugs including tetracyclines, aminoglycosides, macrolides, sulphonamides,
quinolones
Drugs acting on the cardiovascular system
Drugs acting on the endocrine system
Steroids including cutaneous applications
Practical Aspects of in-silico drug danger
ASSESSMENT
Written test of 3 hours:
Assignment:
95%
5%
RESULT
Percentage mark and grade
LECTURERS
Claire Shoemake (Co-ordinator)
Mary Ann Sant-Fournier
READING LIST
WILLIG SH. Good Manufacturing Practices for Pharmaceuticals - a plan for total quality
control, 3rd edn. Stoker, ed. Marcel Dekker Inc., Switzerland, ISBN 0-8247-8594-0
BRYANT R. The Pharmaceutical Quality Control Handbook, 1989. Aster Publications
Corp., USA
GOLDBERGER F. Pharmaceutical Manufacturing, Quality Management in the
Industry. The Pharmaceutical Press, London
Publications of the Pharmaceutical Inspection Convention (PIC). EFTA, Switzerland
Publications of the Commission of the European Communities. Luxembourg
AKERS MJ. Parenteral Quality Control: Sterility, Pyrogen, Particulate and Package
Integrity Testing. Marcel Dekker Inc., New York, ISBN 0-8247-9088-X
BECKETT AH, STENLAKE JB. Practical Pharmaceutical Chemistry, Part I & II, 4th
edn. Humanities Press International, Inc., ISBN 0-485-11323-6
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Course Catalogue Year 2009-2010
8/18/2010
11th edn. The Pharmaceutical Press 1979, ISBN 0-85369-129-0
LEMKE TL. Review of organic Functional Groups: Introduction to Medicinal Organic
Chemistry, 3rd edn. Williams & Wilkins 1991, ISBN 0-8121-1428-0
FOYE WO. Principles of Medicinal Chemistry, 3rd edn. Williams & Wilkins 1988,
ISBN 0-8121-1098-6
SMITH HJ AND WILLIAMS H. Eds. Introduction to the Principles of Drug Design,
Wright PSG Boston, 1983.
ADRIEN ALBERT, Selective Toxicity:
The Physico-chemical basis of Therapy
6th Edn Chapman & Hall (1979) ISBN 0-412-1555650-4
SOUIDIJN W. The Role of Medicinal Chemistry in Drug Research, Pharmaceutische
Weekblad, Scientific Edition 1991; 13(4): 161-6
Burger’s Medicinal Chemistry & Drug Discovery Part I-III, 3rd edn., Wolff ed. John
Wiley and Sons, ISBN 0-471-57556-9
* Pre-requisites: PHR 2203 and PHR 2026.
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Course Catalogue Year 2009-2010
UNIT CODE:
PHR 3307*
8/18/2010
UNIT TITLE:
PHARMACEUTICAL
FORMULATIONS
TYPE
Lectures and practicals
NUMBER OF ECTS CREDITS: 4
LEARNING OBJECTIVES
To expose the student to the various aspects which have to be considered when formulating
preparations for use as medicines, how these aspects of formulation are influenced by the
proposed route of administration, as well as how these same aspects effect the therapeutic
profile of the drugs in use.
To expose the student to the hands on application of principles of pharmaceutical
formulation.
To consider special features of controlled release dosage forms and factors influencing their
formulation.
CONTENT
Sterilised products
Total parenteral nutrition
Sterilisation processes and methods
Controlled release dosage forms
Relevant calculations
Demonstration of hands-on application of principles underlying bulk properties of powders,
dry granulation and angle of repose, flow factor, grinding and sieving, microscopical methods
and the Andreason pipette method to determine particle size.
ASSESSMENT
Written test of 1.5 hours
Practicals
75 %
25 %
RESULT
Percentage mark and grade
LECTURER/DEMONSTRATORS
Maurice Zarb Adami (Co-Ordinator)
Ingrid Ross
READING LIST
Aulton, M. Pharmaceutics: The Science of Dosage Form Design. 2001. Churchill
Livingstone. ISBN 0443055173
Gennaro, A. Remington: The Science and Practice of Pharmacy. 1997. Mack Publishing
Company. (18th edition). ISBN 0912734051.
*Pre-requisites: PHR 1301 and PHR 2304
70
Course Catalogue Year 2009-2010
UNIT CODE:
PHR 3208
8/18/2010
UNIT TITLE:
PHARMACOGNOSY AND
NATURAL PRODUCTS
TYPE
Lectures
NUMBER OF ECTSCREDITS: 4
LEARNING OBJECTIVES
To impart biological, biochemical and agronomic background information relating to natural
drugs and to introduce the student to the locally available crude drugs.
CONTENT
An introduction to the history of the utilization of medicinal plants
The principles and applications of Ethnobotany and Ethnopharmacology
A comprehensive introduction to secondary metabolites mainly terpenoids, alkaloids
flavonoids, tannins, coumarins, glycosides
In vitro and in vivo testing of secondary metabolites from Plants
Phytomedicines used in Modern Therapies
Alternative medicine: Herbal Medicine, Aromatherapy, Apitherapy and Homeopathy
Nutraceuticals
Legislation: Medicine or Food?
Poisonous Plants
ASSESSMENT
Written test of 1 hour
Assignment
60%
40%
RESULT
Percentage mark and grade
LECTURERS
Maurice Zarb Adami (Co-ordinator)
Everaldo Attard
READING LIST
HEINRICH, BARNES, GIBBONS, WILLIAMSON. Fundamentals of Pharmacognosy and
Phytotherapy, Churchill Livingstone, London 2003
LECTURE NOTES: http://staff.um.edu.mt/eatt1/pharmacy.html
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Course Catalogue Year 2009-2010
UNIT CODE:
PHR 3306*
8/18/2010
UNIT TITLE:
PHARMACEUTICS III
TYPE
Lectures, Practicals, Tutorials
NUMBER OF ECTS CREDITS: 4
LEARNING OBJECTIVES
To describe tablet and capsule formulation and manufacturing processes needed to produce
tablets and capsules of high standard in accordance with the specifications laid down by the
BP, USP etc. Problems arising during manufacture and storage will be discussed.
To highlight value of the dissolution test as a method of tablet quality control, including the
effect of various formulation and processing parameters on the dissolution of tablets. The
students will learn the effect of various formulation and processing parameters on the
dissolution of tablets. The unit will also introduce the student to the rationale behind
pharmaceutical quality assurance.
To introduce Good Manufacturing Practice Principles.
CONTENT
Tablet and Capsule Manufacturing
Tablet formulation: diluents, adsorbants, binding agents, disintegrants, colouring and
flavouring
Granulation: dry granulation, slugging, moist granulation, granule drying, lubricants and
glidants
Tablet design: route of administration, dose uniformity, stability and storage, acceptability,
excipients, interactions
Compressed tablets: types of tablets, manufacture of tablets - direct compression, problems
associated with the manufacture of tablets, tablet strength, capping, prevention of capping,
tablet standards - Pharmacopoeial considerations
Coating: reasons for coating tablets, sugar coating, problems of sugar coating, film coating,
problems associated with film coating, fluid bed coating, sustained release coating, enteric
coating
Capsules: raw material, hard gelatin capsules, soft gelatin capsules, advantages of soft
gelatin capsules, formulation, bioavailability aspect, packaging techniques
Dissolution and Quality Control
Physical process of dissolution, Fick’s laws, mathematical description of dissolution, test
parameters.
Effect of processing parameters (compression, mixing, coating) and formulation parameters
(diluents, glidants, disintegrants) on tablet dissolution.
Introducing Good Manufacturing Practice: The importance of Quality Control and Quality
assurance in the pharmaceutical industry. A site visit to a pharmaceutical company.
Practical sessions in the pharmaceutical industry
ASSESSMENT
Written test of 2 hours held at the end of the second semester.
RESULT
Percentage mark and grade
LECTURERS
Maurice Zarb-Adami (Co-ordinator)
Edwina Brejza
READING LIST
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Course Catalogue Year 2009-2010
8/18/2010
The British Pharmacopoeia Vols I & II. The Stationery Office. ISBN 0113222580.
European Department for the Quality of Medicines, Council of Europe. The European
Pharmacopoeia 3rd edition. 1996. ISBN 9287129916.
Lund W. The Pharmaceutical Codex: Principles and Practice of Pharmaceutics. 1994:
Pharmaceutical Press (12th edition) ISBN 0853692904.
British Medical Association and Royal Pharmaceutical Society of Great Britain. The
British National Formulary, No. 45. 2003. Pharmaceutical Press: London. ISBN 0853695555.
Sweetman SC. Martindale: The Complete Drug Reference. London: Pharmaceutical
Press. Latest Edition.
Collett, D., Aulton, M. Pharmaceutical Practice. 1998. Churchill Livingstone. ISBN
044305729X.
Gennaro, A. Remington: The Science and Practice of Pharmacy. 1997. Mack Publishing
Company. (18th edition). ISBN 0912734051.
Martin, A., Bustamente, P., Chun A.H.C. Physical Pharmacy: Physical Chemical
Principles in the Pharmaceutical Sciences. 1993. Lea & Febiger. (4th edition). ISBN
0812114388.
Aulton, M. Pharmaceutics: The Science of Dosage Form Design. 2001. Churchill
Livingstone. ISBN 0443055173.
* Pre-requisites: PHR 1301 and PHR 2304.
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Course Catalogue Year 2009-2010
UNIT CODE: PHR3340
8/18/2010
UNIT TITLE: PHARMACOECONOMICS AND
MANAGEMENT IN PHARMACY
TYPE Lectures and Seminars
NUMBER OF ECTS CREDITS: 2
LEARNING OBJECTIVES
To obtain an appreciation of the impact of medication costs on the financial resources of the
patient and of the country.
To understand the role of management in the efficient provision of pharmacy services, and
the tools that can be used to achieve such efficiency.
CONTENT
The impact of disease on the patient, the family, society, the economy and the state.
Basic concepts of economics as applied to health in general and to pharmaceuticals in
particular.
The major pharmacoeconomic tests that are available to determine the efficiency, utility of
and benefits arising from the use of different medicines and how these can be minimised.
The requirement of regulation in pharmaceutical production, marketing and dispensing, and
the effect that this has on the cost of therapy.
The pharmacoeconomic factors that need to be taken into account along with factors of other
nature when establishing treatment protocols in particular circumstances.
Requirements for running efficient pharmacy services both in the community and in
hospitals.
The link between medicines management and clinical governance, risk management,
forming effective relationships between primary and secondary care and improving financial
planning.
ASSESSMENT
Written test of two hours
RESULT
Percentage mark and grade
LECTURERS/DEMONSTRATORS
Maurice Zarb Adami,
Lilian Wismayer,
Pierre Fava
READING LIST
Kayne SB. Ed. Pharmacy Business Management. London: Pharmaceutical Press, 2005
(ISBN: 978 0 85369 563 9)
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Course Catalogue Year 2009-2010
UNIT CODE:
CPH 3011*
8/18/2010
UNIT TITLE:
PHARMACOLOGY D
TYPE
Lectures and seminars
NUMBER OF ECTS CREDITS: 4
LEARNING OBJECTICES
i.
to understand the basic pharmacology and mode of action of drugs used in
immunopharmacology, oncology and hormones
ii.
to present an overview of the molecular pharmacology of specific drugs, and to
discuss the molecular-based research methodology and tools.
CONTENT
Cell differentiation and Antigen presenting cells
Immune defence mechanisms: T cells and B cells
Cytokines and Methods of immunosuppression
Basic principles of chemotherapy and drugs used in oncology
Oral and injectable hypoglycaemic agents
Thyroid hormones
Male and female sex hormones, contraceptives, HRT
Vitamin D and parathyroid hormone and Calcitonin
Recombinant drugs and Gene therapy
Bioinformatics, online databases, data mining
Specific receptor subtypes e.g. opioid receptors, histamine receptors, insulin receptor,
cytokine receptors
Molecular modes of action of enzyme modifiers e.g. COX-inhibitors, cholinesterase inhibitors
Molecular aspects of discovery of novel drugs and drug targets: The Human Genome
database
Research tools for studying pharmacological actions and pathways: overview of laboratory
tools including PCR, electrophoresis, sequencing, genotyping, molecular cloning, cell
culturing, transfections, expression analysis, microarray technology, transgenic animals
ASSESSMENT
Written test of 2 hours held at end of study unit.
RESULT
Percentage mark and grade
LECTURERS
Roger Ellul Micallef
J J Borg
Frederick Fenech
Janet Mifsud
Anthony Fenech
Mark Micallef
READING LIST
Shargel and Yu. Applied Biopharmaceutics. McGraw-Hill
Brody, Larner, Minneman. Human Pharmacology - Molecular to Clinical.
Mosby, Hardman, Limbird, Molinoff, Rudden and Gilman (Eds). Goodman and Gilman's
The Pharmacological Basis of Therapeutics, Pergamon Press.
Laurence And Bennett. Clinical Pharmacology. Churchill Livingston
Rang, Dale and Ritter. Pharmacology. Churchill Livingstone.
Rowland and Tozer. Clinical Pharmacokinetics: concepts and applications. Lippincott,
Williams & Wilkins.
* Pre-requisites: CPH 2010, CPH 2011 and CPH 3010
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Course Catalogue Year 2009-2010
UNIT CODE:
CHE 3141
8/18/2010
UNIT TITLE:
SEPARATION TECHNIQUES
TYPE
Lectures
NUMBER OF ECTS: 2
LEARNING OBJECTIVES
Identify traditional and modern methods of separation
Distinguish between techniques for analysis and preparation
Apply the techniques for qualitative and quantitative purposes
Be able to select the appropriate technique for specific pharmaceutical laboratory
measurements
CONTENT
Principles and Introduction: Solvent Extraction, Column Chromatography Partition and
Absorption; Thin Layer and Paper; Ion Exchange Chromatography.
Gas Chromatography: Separation efficiency and resolution; Instrumentation Columns and
stationary phases; Universal detectors; Applications.
Liquid Chromatography: Instrumentation; The mobile phase; Columns and stationary
phases; Universal detectors; Applications.
ASSESSMENT
85 % Examination
15 % Progress Test
LECTURER
Claire Shoemake (Co-ordinator)
George Peplow
READING LIST (recommended)
Analytical Chemistry - Approved Text to the Federation of European Chemical Society
Curriculum Society Curriculum, Ed. Robert Kellner. Pub l: Wiley-VCH (1998).
Analytical Chemistry by Gray D. Christian 5th Edn., Wiley (1994).
Supplementary reading
Analytical Chemistry by Douglas A Skoog and Donald M West. 6th Edn.
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Course Catalogue Year 2009-2010
8/18/2010
UNIT CODE: PAT 3322
UNIT TITLE: GENERAL AND PHARMACEUTICAL MICROBIOLOGY III
TYPE:
Lectures
NUMBER OF ECTS :
4
PRE-REQUISITE
General and Pharmaceutical Microbiology I and II
ASSESSMENT
Written, at the end of the first semester
RESULT
Percentage mark and grade
LECTURERS
Prof. Paul Cuschieri (PVC)
Dr. Christopher Barbara (CB)
Dr Michael A. Borg (MB)
This study covers:
Immunisation (Bacterial Preparations) – Prof. Paul Cuschieri (PVC)
Immunisation (Viral Preparations) – Dr Christopher Barbara (CB)
Infection control – Dr Michael A. Borg (MB)
Description
Lectures:
Invasive pneumococcal disease and pneumococcal vaccines
Typhoid and typhoid vaccines
Meningococcal disease and meningococcal vaccines
Invasive Haemophilus influenzae capsular type b infections and
HIB vaccines
Diphtheria and diphtheria toxoid preparations
Tetanus and tetanus toxoid preparations
Whooping cough and Bordetella pertussis vaccines
The routine immunisation schedule
Hepatitis A vaccine
Hepatitis B vaccine
Measles vaccines
Mumps vaccines
Rubella vaccines
Principles of transmission of infectious diseases
Infection control – methods and cost effectiveness
Hand hygiene
Multiresistant organisms and their control
Prevention of multiresistance & judicious use of antibiotics in
hospitals
Prevention of travel associated infections
LEARNING OBJECTIVES
To continue to deal with systematic microbiology where the biological
characteristics of the major genera and species are described, together
with the clinical infections that these organisms cause.
To describe the theoretical and practical aspects of active and passive
immunisation against infectious diseases. Particular attention will be paid
to locally endemic infections and to vaccination programmes.
The basic principles of infection control in the hospital setting are also
covered.
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Course Catalogue Year 2009-2010
Reading List
8/18/2010
Recommended Textbooks:
th
Medical Microbiology by David Greenwood et al; 17 Ed. 2007,
ISBN04443102090, Churchill Livingstone
Lectures:
Invasive pneumococcal disease and pneumococcal vaccines (2 lectures, PVC)
Typhoid and typhoid vaccines (2 lectures, PVC)
Meningococcal disease and meningococcal vaccines (2 lectures, PVC)
Invasive Haemophilus influenzae capsular type b infections and HIB vaccines (1
lecture, PVC)
Diphtheria and diphtheria toxoid preparations (2 lectures, PVC)
Tetanus and tetanus toxoid preparations (2 lectures, PVC)
Whooping cough and Bordetella pertussis vaccines (2 lectures, PVC)
The routine immunisation schedule (1 lecture, PVC)
Hepatitis A vaccine (1 lecture, CB)
Hepatitis B vaccine (1 lecture, CB)
Measles vaccines (1 lecture, CB)
Mumps vaccines (1 lecture, CB)
Rubella vaccines (1 lecture, CB)
Principles of transmission of infectious diseases (1 lecture, MA)
Infection control – methods and cost effectiveness (1 lecture, MA)
Hand hygiene (1 lecture, MA)
Multiresistant organisms and their control (1 lecture, MA)
Prevention of multiresistance & judicious use of antibiotics in hospitals (1 lecture,
MA)
Prevention of travel associated infections (1 lecture, MA)
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Course Catalogue Year 2009-2010
UNIT CODE:
CPH 3010*
8/18/2010
UNIT TITLE:
PHARMACOLOGY C
TYPE
Lectures and seminars
NUMBER OF ECTS: 4
LEARNING OBJECTIVES
I. To understand the disposition of drugs in the body and the effects of drug
metabolising enzymes, and organ clearance mechanisms in PK/PD
II. To understand the basic pharmacology and mode of action of drugs used to treat
neurological and respiratory disorders; pharmacology of steroids
CONTENT
Multi compartment models
Metabolism and biotransformation : Phase I and phase II reactions
Physiological models in pharmacokinetics: Hepatic and renal clearance
Pharmacokinetic principles in oral multiple dosage drug regimens
Infusion drug regimens pharmacokinetics
Basic principles in epilepsy and classification in epilepsy
Traditional antiepileptic drugs and new antiepileptic drugs
Pharmacokinetic principles in prescribing antiepileptic drugs
Drugs used in other chronic neurological and movement disorders;
Parkinson’s disease and Alzheimer’s disease
Drugs affecting the Nitric Oxide pathways
Inflammatory processes in asthma
Drugs used in asthma: beta-adrenergic receptor agonists, anticholinergic agents,
methylxanthines, antileukotriene agents
Drugs used in allergies
Glucocorticoids: models of action at cellular level, regulation of synthesis,
Structure activity relationships, adverse effects
ASSESSMENT
Written test of 2 hours held at end of study unit.
RESULT
Percentage mark and grade
LECTURERS
Roger Ellul-Micallef
Anthony Fenech
Janet Mifsud
Charles Scerri
READING LIST
Brody, Larner, Minneman. Human Pharmacology - Molecular to Clinical.
Mosby, Hardman, Limbird, Molinoff, Rudden and Gilman (Eds). Goodman and Gilman's
The Pharmacological Basis of Therapeutics, Pergamon Press.
Laurence and Bennett. Clinical Pharmacology. Churchill Livingston
Rang, Dale and Ritter. Pharmacology. Churchill Livingstone.
Rowland and Tozer. Clinical Pharmacokinetics: concepts and applications. Lippincott,
Williams & Wilkins.
Shargel and Yu. Applied Biopharmaceutics. McGraw-Hill.
* Pre-requisites: CPH 2010 and CPH 2011.
79
Course Catalogue Year 2009-2010
UNIT NO:
PHR 3030
8/18/2010
UNIT TITLE:
TOTAL QUALITY SYSTEMS I
TYPE
Lectures
NUMBER OF ECTS: 2
LEARNING OBJECTIVES
To provide the student with the ability to formulate strategies for assessing the performance
of processes and the conformance of food to specifications and legislation and to contribute
directly to quality assurance to ensure that production of food conforms with legal
requirements. On successful completion the student will be able to participate in the
development and management of quality assurance systems in the food industry; assess
the value of the various techniques used in quality assurance; participate in the application
of total quality systems; and establish appropriate controls for assessing the conformance of
products to specifications and the performance of production processes.
CONTENT
Introduction to quality control- Definition of quality, Inspection, Quality Assurance, Quality
Control, Design Requirements, Correction of Quality Deficiencies, Quality Data, Quality
Audits, Total Quality Management. Cost of Quality- Quality Costs, Minimum Overall Cost,
Zero Defects, Manufacturing Cost & Quality, Customer Service. Quality of Design- Quality of
Manufactured Part, Quality of Design, Quality of Conformance, Designers' Responsibility for
Quality, Variable and Attributes, Routine Checking of Inspection & Test Equipment, NonVisual Standards, Critical, Major & minor Defects. Control of Incoming Material- Vendor
Appraisal, Principles of Material Control, Buying Specifications, Sources of Supply, Quality
Audits.
ASSESSMENT
Written test of 1 hour held at the end of the second semester
LECTURERS
Claire Shoemake (Co-ordinator)
Stephen Ferrito
80
Course Catalogue Year 2009-2010
UNIT CODE: PAT 3324
TYPE
8/18/2010
UNIT TITLE: ANTIMICROBIAL CHEMOTHERAPY I
Lectures
NUMBER OF ECTS CREDITS
2
PREREQUISITES
PAT1322, PAT2322 and PAT3322
ASSESSMENT
Written, at the end of the second semester
RESULT
Percentage mark and grade
LECTURERS
Prof. Paul Cuschieri (PVC)
Dr Paul Caruana (PFC)
DESCRIPTION
This study unit covers Antibiotics.
Coordinator
Lectures:
Introduction: definitions; historical perspectives; properties of
therapeutically useful antibiotics; classification of antibiotics
Drug combinations, isobolograms
Fusidanes
Nitroimidazoles – metronidazole
Sulphonamides and the diaminopyrimidines
Aminoglycosides
Lincosamides
Macrolides
Tetracyclines
Chloramphenicol
LEARNING OBJECTIVES
These credits are intended to outline the properties of the major groups of
antimicrobial agents on key drugs, discuss their indications, understand
antibiotic selectivity by identifying enzymes, modes of action and apply the
principles underlying their correct usage in treatment and prophylaxis.
Recommended Textbooks:
READING LIST
th
Medical Microbiology by David Greenwood et al; 17 Ed. 2007,
ISBN04443102090, Churchill Livingstone
Goodman and Gillman's The Pharmacological Basis of Therapeutics
th
Laurence L. Brunton et al, 11 Ed, 2006 ISBN 0071422803
Lectures:
Introduction: definitions; historical perspectives; the development of antibiotics;
sources of naturally occurring compounds; the concept of selective toxicity;
properties of therapeutically useful antibiotics; microbicidal and microbistatic effects;
classification of antibiotics; competitive and non-competitive inhibition; lethal
synthesis (2 lectures, PVC)
81
Course Catalogue Year 2009-2010
8/18/2010
Drug combinations, isobolograms (1 lecture, PVC)
Fusidanes (1 lecture, PVC)
Nitroimidazoles – metronidazole (2 lectures, PVC)
Sulphonamides and the diaminopyrimidines (2 lectures, PVC)
Aminoglycosides (3 lectures, PFC)
Lincosamides (1 lecture, PFC)
Macrolides (2 lectures, PFC)
Tetracyclines (1 lecture, PFC)
Chloramphenicol (1 lecture, PFC)
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