Peter M. Cala, Ph.D.
Clinical Interests
Peter M. Cala's broad research interests include membranes and transport with particular emphasis
on the Na/H exchange (NHE1) and its role in cell volume and pH regulation. His current focus is
on establishing structural correlates of NHE1 function based upon studies of NHE1 subtype
chimeras and EPR spectroscopy. His research also includes NMR studies of the basis for hypoxiainduced cell injury using the rabbit heart as model.
Title
Human Physiology and Membrane Biology
Professor and Chair of
Specialty
Department
Education
Pharmacology, Physiology
Physiology and Membrane Biology
Ph.D., Case Western Reserve University School of Medicine, Cleveland, Ohio, 1974
B.A., Case Western Reserve University, Cleveland, Ohio, 1970
Fellowships
Professional Memberships
Duke University Medical Center, Durham, North Carolina, 1974-76
American Physiological Society
Biophysiological Society
Red Blood Cell Club
Society for General Physiology
Select Recent Publications
Ortiz-Acevedo A, Rigor RR, Maldonado HM, Cala PM. Coordinated control of volume regulatory
Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells. Am J Physiol Cell Physiol.
2009 Nov 25. [Epub ahead of print]
Ortiz-Acevedo A, Rigor RR, Maldonado HM, Cala PM. Activation of Na+/H+ and K+/H+ exchange
by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volumeinduced ion flux activity. Am J Physiol Cell Physiol. 2008 Nov;295(5):C1316-25. Epub 2008 Sep
17.
King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by
amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras
of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27):
19716-27. Epub 2007 May 10.
Holt, M.E., S.A. King, P.M. Cala and S.E. Pedersen. Regulation of the Pleuronectes americanus
Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of the Ser/Thre
protein phosphatases. Cell. Biochem. Biophys. 45: 1-18. 2006.
Peter M. Cala, Ph.D.
Pedersen, S.F., M.E. O’Donnell, S.E. Anderson and P.M. Cala. Physiology and pathophysiology of
Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain and blood. Am. J. Physiol.
Regul. Integr. Comp. Physiol. 291: R1-R25. 2006.
Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH,
Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64. 2005.
Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter
M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage,
cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576. 2003.
Ho HS, H. Liu, P.M. Cala and S.E. Anderson. Hypertonic perfusion inhibits intracellular Na and Ca
accumulation in hypoxic myocardium. American Journal of Physiology 278: (Cell Physiol. 47)
C953-C964. 2000.
McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display
altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of
Physiology 278: (Cell Physiol. 47) C676-C688.
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