Robert F. Berman, Ph.D.
Clinical Interests
Dr. Berman's research interests focus on mechanisms of brain injury and recovery,
neurodevelopmental disorders including autism, neuroplasticity, and brain mechanisms of learning
and memory. Current studies in Dr. Berman’s laboratory include the role of calcium in brain injury
and the potential of specific neuronal calcium channel antagonists to protect the brain after injury.
Studies are carried out at the cellular, neurochemical, neuroanatomical and behavioral levels.
Cell/molecular experiments include in vitro measurements of intracellular calcium levels in primary
neuronal and glial cell cultures. Neurotransmitter changes associated with brain injury are assessed
by in vivo microdialysis and HPLC (e.g., catecholamines, excitatory amino acids, purines). Dr.
Berman also examines ultrastructural changes in the brain using standard histological procedures
and stereological quantification of cell numbers. At the behavioral level, memory and learning,
sensory perception, and motor performance are assessed in animals in response to treatment with
novel neuroprotective agents. The overall goals of this research are to understand the cellular
mechanisms that lead to neuronal damage and behavioral disability after brain injury, and to
develop specific treatments that will facilitate recovery and improve neurological outcome. A
second area of interest is the effects of exposure to environmental toxins (e.g., mercury, PCBs,
alcohol) early in development on brain growth and behavior. Dr. Berman is particularly interested
in the possibility that environmental toxins may contribute to the development of
neurodevelopmental disorders such as autism. He is currently developing and using animal models
of neurodevelopmental disorders (e.g., Fragile X premutation, BTBR)to examine brain development
and the expression of complex behaviors, including memory, attention and social communication
after prenatal and neonatal toxin exposure.
Title
Chair of the Graduate Program in Neuroscience
Director of the Neurosciences Lab
Professor and Vice Chair of Research
Specialty
Neurodevelopmental Disorders, Neuroscience Research, Neurotoxicology, Traumatic Brain Injury
Department
Neurological Surgery
Division
Neurological Surgery
Center/Program Affiliation
Center for Neuroscience
UC Davis MIND Institute
Education
Robert F. Berman, Ph.D.
Ph.D., University of Utah School of Medicine, Salt Lake City, Utah, 1976
B.A., University of Utah, Salt Lake City, Utah, 1970
M.S., University of Utah, Salt Lake City, Utah, 1974
Fellowships
Professional Memberships
University of North Carolina, Chapel Hill, North Carolina, 1976-1978
American Society for Neurochemistry (ASN)
International Behavioral and Neural Genetics Society
International Society for Biomedical Research on Alcoholism
National Neurotrauma Society
Research Society on Alcoholism
Society for Neuroscience
Honors and Awards
National Associate of the National Academies (designated lifetime member), 2002
Visiting Scientist Award, Medical Research Council of Sweden, Karolinska Institute, Stockholm,
Sweden, 1995
Visiting Professor, University of Otago, Dunedin, New Zealand, 1992
Select Recent Publications
Berman RF, Murray KD, Arque G, Hunsaker MR, Wenzel HJ. Abnormal dendrite and spine
morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X
premutation. Epilepsia. 2012 Jun;53 Suppl 1:150-60. doi: 10.1111/j.1528-1167.2012.03486.x.
Diep AA, Hunsaker MR, Kwock R, Kim K, Willemsen R, Berman RF. Female CGG knock-in mice
modeling the fragile X premutation are impaired on a skilled forelimb reaching task. Neurobiol
Learn Mem. 2012 Feb;97(2):229-34. Epub 2011 Dec 21.
Tassone F, Greco CM, Hunsaker MR, Seritan AL, Berman RF, Gane LW, Jacquemont S, Basuta K,
Jin LW, Hagerman PJ, Hagerman RJ. Neuropathological, clinical and molecular pathology in female
fragile X premutation carriers with and without FXTAS. Genes Brain Behav. 2012 Mar 30. doi:
10.1111/j.1601-183X.2012.00779.x. [Epub ahead of print]
Hunsaker MR, Arque G, Berman RF, Willemsen R, Hukema RK. Mouse models of the fragile x
premutation and the fragile X associated tremor/ataxia syndrome. Results Probl Cell Differ. 2012;
54:255-69.
Hunsaker MR, Greco CM, Spath MA, Smits AP, Navarro CS, Tassone F, Kros JM, Severijnen LA,
Berry-Kravis EM, Berman RF, Hagerman PJ, Willemsen R, Hagerman RJ, Hukema RK. Widespread
non-central nervous system organ pathology in fragile X premutation carriers with fragile Xassociated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathol. 2011 Oct;122(4):
467-79. doi: 10.1007/s00401-011-0860-9. Epub 2011 Jul 23.
Hunsaker MR, von Leden RE, Ta BT, Goodrich-Hunsaker NJ, Arque G, Kim K, Willemsen R,
Robert F. Berman, Ph.D.
Berman RF. Motor deficits on a ladder rung task in male and female adolescent and adult CGG
knock-in mice. Behav Brain Res. 2011 Sep 12;222(1):117-21. Epub 2011 Mar 31.
Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW,
Berman RF, Jin LW, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the
hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb
8;2(1):2.
Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen
R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the
Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 1;20(1):64-79.
Epub 2010 Oct 8.
Beller JA, Gurkoff GG, Berman RF, Lyeth BG. Pharmacological enhancement of glutamate transport
reduces excitotoxicity in vitro. Restor Neurol Neurosci. 2011 Jan 1;29(5):331-46. doi: 10.3233
/RNN-2011-603.
Fedor M, Berman RF, Muizelaar JP, Lyeth BG. Hippocampal ? dysfunction after lateral fluid
percussion injury. J Neurotrauma. 2010 Sep;27(9):1605-15.
Wenzel HJ, Hunsaker MR, Greco CM, Willemsen R, Berman RF. Ubiquitin-positive intranuclear
inclusions in neuronal and glial cells in a mouse model of the fragile X premutation. Brain Res.
2010 Mar 8;1318:155-66. Epub 2010 Jan 4.
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