New
THIOPURINE DRUG METABOLITES
THIOPURINE DRUG METABOLITES
EFFECTIVE
Jan. 26, 2016
LABSP000574
Effective January 26, 2016, the above test will become orderable. As part of the UCDMC
Choosing Wisely Initiative, this replaces the test formerly sent to Prometheus and is
performed at ARUP laboratories. This test is performed with newer methodology with
greater sensitivity, specificity, and cost-effectiveness.
COLLECT:
EDTA 4.0 mL
TAT:
1-6 days
Methodology:
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Reference Range: 230 to 400 pmol/8 x 108 RBC
Concentrations of 6-thioguanine nucleotide (6-TGN) less than 230 pmol/8 x 108 RBC may
indicate a reduced response to therapy; 6-TGN concentrations greater than 400 pmol/8 x 108
RBC may indicate a higher risk for leukopenia. Concentrations of 6-methyl mercaptopurine
nucleotide (6-MMPN) greater than 5700 pmol/8 x 108 RBC may indicate a higher risk for
hepatotoxicity.
If you have questions or need additional information please contact Laboratory
Client Services at 734-7373 or email pathologyclientservices@ucdmc.ucdavis.edu.
LIS mnemonic: THIOMET
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