17) Xulei Liu, Crawford L, Matthew Shotwell, Wang JP, David Edwards, “Daily risk of
epidural catheter infection.”
18) Lauren Poe, Yangdong Jiang, Travis Hamilton, Vazquez R, Lizdas DE, Lampotang S,
Edwards DA, “A mixed reality simulator augmented with real-time 3D visualization enhances
resident learning of a novel technique and successful placement of difficult epidural catheters.”
Department of Anesthesiology
19) Antonio Hernandez, Liming Luan, Julia Bohannon, Benjamin Fensterheim, Yin Guo,
Naeem Patil, Wang and Edward Sherwood, “Role of MyD88- and Trif-dependent signaling in
MPLA-induced neutrophil mobilization and recruitment.”
20) Christina Crotts, Amanda Lorinc, Maria Sullivan, Amanda Dickert, Ashley Baracz and
Michelle Acton, “Pediatric preoperative handovers: Does a checklist improve information
exchange?”
21) Melissa Bellomy, Bradley Kook and Mark Rice, “Rocuronium-induced anaphylaxis: Attempted reversal with sugammadex.”
ABOUT DR. KHARASCH
Evan D. Kharasch, MD, PhD, is the Russell D. and Mary B. Shelden Professor of Anesthesiology in the Department of Anesthesiology at Washington University in St. Louis. He is also a
professor in the Department of Biochemistry and Molecular Biophysics and holds appointments in the Washington University Pain Center and Siteman Cancer Center. He joined
Washington University in St. Louis in 2005.
12thCompassionate
Annual | Creative | Committed | Collaborative
Research
Symposium
May 6, 2016 | 6:30 am-2:30 pm
Dr. Kharasch leads an active research program in basic, translational, and clinical pharmacology and is a practicing anesthesiologist. His research focuses on anesthetic and analgesic
drugs, drugs of abuse, and addiction therapies, toward the goal of understanding hepatic and
extra-hepatic drug metabolism and drug transport (hepatic, renal, intestinal, and the bloodbrain barrier), pharmacokinetics, pharmacodynamics, pharmacogenetics, toxicity, drug
interactions, and variability in patient response. These are directed toward optimizing drug
disposition, drug safety, clinical effectiveness, and patient satisfaction.
His research also focuses on the development and application of novel noninvasive biomarkers and tests. A major area of focus is noninvasive biomarkers for population screening
and differential diagnosis of kidney cancer. He holds patents for that technology, which is
currently undergoing commercialization. Dr. Kharasch’s research has been continuously
NIH-funded for two decades. He is the author of more than 230 research papers, as well
as book chapters, is the editor of two major textbooks on anesthetic pharmacology, and is
editor-in-chief, elect, of Anesthesiology. Dr. Kharasch is an elected member of the Institute
of Medicine of the National Academy of Sciences.
Dr. Kharasch served as the vice chancellor for Research at Washington University in St.
Louis from 2009 to 2014, where he was responsible for overseeing research and related
administrative and operational activities of the university, including the university’s Office of
Technology Management, which is responsible for the protection and commercialization of
university intellectual property. He also led a university-wide initiative in research innovation and entrepreneurship to expand Washington University’s research culture in research
commercialization.
Dr. Kharasch earned his undergraduate degree (medical science), his medical degree, and his
doctorate (pharmacology) from Northwestern University. He received anesthesiology training at the University of Washington in Seattle, where he remained on faculty for 17 years.
Guest Lecturer
Evan D. Kharasch, MD, PhD
Russell D. and Mary B. Shelden Professor of Anesthesiology
Professor, Biochemistry and Molecular Biophysics
Director, The Center for Clinical Pharmacology
Editor-in-Chief (Elect), Anesthesiology
Washington University School of Medicine, St. Louis, MO
Highlighting the current research of clinical and translational investigators
and basic scientists
POSTER PRESENTATIONS
PROGRAM
6:30 - 7:30 am
BH ROBBINS LECTURE | Evan D. Kharasch, MD, PhD | 214 Light Hall
7:30 - 8:00 am
BREAKFAST
8:00 - 9:30 am
POSTER PRESENTATIONS University Club Hermitage Room
University Club Cumberland Room
SCIENTIFIC PRESENTATIONS | University Club Cumberland Room
Moderator Jerod Denton, PhD
9:30 - 9:45 am
WELCOME | Vice-Chair of Research, Edward Sherwood, MD, PhD
9:45 - 10:00 am
Loren Smith, MD, PhD | “A novel association between high density
lipoprotein levels and the risk of acute kidney injury after cardiac surgery”
10:00 - 10:15 am
Michele Salzman, BS | “Cellular protection through copolymer cell membrane stabilization for ischemia-reperfusion injury”
10:15 - 10:30 am
Teus Kappen, MD, PhD | “Intraoperative hypotension and adverse
outcomes: finding the right threshold”
10:30 - 10:45 am Adam Kingeter, MD | “Responding to bundled payments: Impact of a
clinically based milestone pathway on cost of cardiac valve procedures”
10:45 - 11:00 am COFFEE BREAK
11:00 - 11:15 am Ben Fensterheim, MSTP | “Metabolic reprogramming of macrophages by TLR4 Agonists”
11:15 - 11:30 am Marcos Lopez, MD | “Intraoperative hyperoxia and outcomes”
11:30 - 11:45 pm Joseph Schlesinger, MD/ Katherine Nash, BS | “Acoustic alarm research in the anechoic chamber”
11:45 - Noon
Michael Chi, MD | “ROS-Responsive microspheres for on-demand
therapy of chronic pain”
Noon - 1:00 pm
LUNCH, Poster presentations continue in Hermitage Room
1:00 - 1:15 pm Daniel Kashima, MSTP | “Toll like receptor 4 regulation of motivation and nucleus accumbens synaptic physiology”
1:15 - 1:30 pm
Jason O’Neal, MD | “Exposure to Cardiopulmonary Bypass and delirium in Cardiac Surgery Patients”
1:30 - 1:45 pm
Heidi Smith, MD, MSCI, FAAP | “Pediatric Delirium: risk factors and Outcomes”
1:45 - 2:00 pm
Rebecca Brindley, PhD | “Serotonergic control of adrenal catecholamine secretion”
2:00 - 2:15 pm
BREAK
2:15 - 2:45 pm
AWARDS PRESENTATION & CLOSING REMARKS
1) Sujay Kharade, Haruto Kurata, Corey Hopkins and Jerod Denton, “Kir4.1 (KCNJ10)
inhibition with a newly developed antagonist induces diuresis in rats.”
2) Julia Bohannon, Liming Luan, Antonio Hernandez, Benjamin Fensterheim, Yin Guo and Edward
Sherwood, “Treatment with TLR4 agonists protects against infection after severe burn injury.”
3) Hanyuan Shi, Maxim Terekhov, Jesse Ehrenfeld and Jonathan Wanderer, “The impact of reduction
of testing at a preoperative evaluation clinic: Value added without adverse outcomes.”
4) Hunter Douglas, Michele Salzman and Matthias Riess, “Intralipid protects rat-isolated hearts
against ischemia-reperfusion injury through nitric oxide-mediated pathways.”
5) Liming Luan, Naeem Patil, Yin Guo, Antonio Hernandez, Julia Bohannon, Benjamin
Fensterheim, Jingbin Wang, Pengcheng Lu, Yaomin Xu, Perenlei Enkhbaatar and Edward
Sherwood, “Lipopolysaccharide and monophosphoryl lipid a induce similar transcriptome profiles in
human blood with the exception of proinflammatory genes.”
6) Rebecca Brindley, Mary Beth Bauer, Randy Blakely and Kevin Currie, “An interplay between the
serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in
sympathoadrenal chromaffin cells.”
7) Naeem Patil, Julia Bohannon, Liming Luan, Yin Guo and Edward Sherwood, “Preclinical
evaluation of Flt3 ligand to improve T Cell adaptive immune response during sepsis.”
8) John Meyer, Patrick Henson, Kelly Kohorst, Britany Raymond, William Lasater, Michael Leersnyder and Raj Gupta, “Evaluation of the quality of preoperative handoffs.”
9) Min Fei, James Blair, Mark Rice, David Edwards, Yafen Liang, Michael Pilla, Matthew Shotwell
and Yandong Jiang, “A comparison of the effectiveness of two commonly used two-handed mask ventilation techniques on unconscious apneic obese adults.”
10) Brandon Turner and Brad Grueter, “mGluR-dependent plasticity of cortical connections in the
Nucleus Accumbens shell.”
11) Carrie Reale, Jie Xu and Jason Slagle, “Medication events impact on intensive care nurses’ workload, mood, and task distribution.”
12) Jason Slagle and Matt Weinger, “Patient and clinician reported Non-Routine Events during
periprocedural cardiac catheterization.”
13) Yin Guo, Liming Luan, Jingbin Wang, Naeem Patil and Edward Sherwood, “Interleukin (IL)-15
plays a critical role in the pathogenesis of CLP- and LPS-induced septic shock by maintaining NK
cells.”
14) Yafen Liang, Jason O’Neal, Jennifer Morse, Matthew Shotwell, Andrew Shaw and
Josh Billings, “Association between intraoperative jugular venous congestion and
postoperative delirium.”
15) Bianca Flores, Lynn Wolfe, Rainelli Koumangoye, Cara Schornak, Salma Omer, Barbara Pushy,
Christopher Lau, David Adams and Eric Delpire, “A patient with multiple-organ failure carries a
truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1.”
16) Rainelli Koumangoye and Eric Delpire,“The Ste20 kinases SPAK and OSR1 travel between cells
through exosomes.”