Multidrug Resistance and ABC Transporters
Baltimore, MD
www.abcam.com/Baltimore
Wednesday, November 5, 2008
8:15
Registration
9:00
Welcome and introduction to scope of the meeting — Dr. Suresh Ambudkar
9:10
Keynote speaker: Dr. Michael Gottesman – Current status of MDR and ABC transporters
9:45
Dr. Suresh Ambudkar – Mechanism of action of MDR-linked ABC drug transporters
10:20
Dr. Robert Innis – Positron emission Tomographic imaging of drug efflux transporters
10:55
Coffee Break
11:15
Dr. David Miller – Regulation of P-glycoprotein and other ABC drug transporters at the bloodbrain barrier
11:50
Dr. Demian Park – Zebrafish: A predictive model for assessing modulators of P-glycoprotein
efflux
12:05
Dr. Zhe-Sheng (Jason) Chen – Tyrosine kinase inhibitors as modulators of multidrug resistance
in cancer
12:25
Lunch Break
1:15
Dr. Wilfred Stein – Polymorphisms within PfMDR1 alter the substrate specificity for antimalarial
drugs in Plasmodium falciparum
1:50
Dr. Maria Baer – Clinical and therapeutic implications of multidrug resistance-associated ABC
drug transporters
2:25
Ms. Maria Fabiana De Rosa – Inhibition of MDR1 as possible therapy for Fabry Disease
2:40
Dr. Daotai Nie – The role of PXR in cancer multidrug resistance
3:00
Coffee break
3:20
Dr. Gilbert Burckart – Drug-drug interactions and regulatory implications for membrane
transporter substrates in drug development
3:55
Dr. Anne-Marie Bleau – Loss of PTEN increases ABCG2 activity in glioma tumor stem cells and
contributes to the MDR phenotype
4:10
Dr. Robert Robey – Novel Inhibitors of ABCG2 identified by high-throughput screening analysis
4:25
Dr. Tian-Yong Zhao – Multidrug Resistance-associated Protein 1 (Mrp1) Localizes in Junction of
Cultured HL1 Cells and Mediates Doxorubicin Induced Stress Signal Transmission between Cells
4:40
Reception and poster session