Welcome to Warwick 2012 the third in our series of... We hope you make many new friends and meet fellow...

Welcome to Warwick 2012 the third in our series of polymer chemistry meetings. We hope you make many new friends and meet fellow polymer chemists from around the world. The program is designed for you all to spend social time as well as scientific time and for you all to get out of the meeting what you want. Please ask us or any of the Warwick people for any help you require and we will do our best to make your stay pleasant and successful. Most of all enjoy yourselves and make the most of our Campus and surrounding areas. Dave, Rachel, Stefan, Andrew, Matt and Remzi. 1 MACRO GROUP UK We would like to thank the following for sponsoring or supporting the conference; Platinum Sponsors Agilent Warwick Polymer MSC Course Gold Sponsors The University of Warwick Sigma Aldrich Lubrizol AWM/ERDF Science City Project Polytherics RSC “Polymer Chemistry” RSC “Soft Matter” Infineum CSIRO Lubrizol The Polymer Centre Silver Sponsor Revolymer 2 Social Program Monday Evening Buffet Dinner and “International Quiz Night” Prizes, Prizes, Prizes! Teams of 10/12 required don’t worry we will fix you up in a team – Rootes Social Building Tuesday Evening 1. 7.30 PM Coaches to Royal Leamington Spa “English pub night” Experience the delights of English pubs with your student guides, Coaches return at 11.15 pm to the University. Places limited please sign up 2. 7.30 PM Coaches to Kenilworth, Walk around Kenilworth Castle with guide and “English Cheese and Beer Evening” at a local Kenilworth Hostelry, Coaches return to the University at 10.30-11.30 PM Invitation required as Places limited – please see conference desk and sign up Wednesday Afternoon 2.00 PM Coaches to Stratford upon Avon, home of William Shakespeare Coaches to Warwick Castle – Entrance tickets available price approx. £15 (see conference desk) Coaches to Leamington Spa (Shopping) and Kenilworth Castle Shopping in Birmingham Bullring – Coaches leave to Coventry Railway station, trains take 20-30 minutes. Please sign up for preferred trip, see next page Wednesday Evening Banquet – with dancing until the early hours. (Bar shuts at 12.30) Guest appearance – Polymer Rock Band (if you wish to Jam see desk) Sign up for tables at the conference desk 3 Kenilworth Castle - Grandeur, Glory, Royalty & Romance! 'This lordly place, where princes feasted and heroes fought' Sir Walter Scott England’s finest and most extensive castle ruin. Kenilworth Castle Millenium Trail - a 1.5 mile walk revealing a glorious and beautiful landscape for you to enjoy. Royal Leamington Spa: perfect mix of Georgian & Victorian architecture, tree-lined avenues, terraces & squares. Visit the Royal Pump Rooms Art Gallery, Museum & Gardens (sample the Spa water!) or sample the excellent number and range of small and large shops. Warwick a delightful town steeped in history best known for its magnificent castle - the finest mediaeval castle in England. Stratford-Upon -Avon - beautifully situated on the River Avon, rich in culture and history but most famous for its literary connections relating to the life & works of William Shakespeare. 4 Posters Poster presenters need to be at their posters at both poster sessions. Odd numbers in the first half and even numbers in the second half. There will be a number of poster prizes which will be presented at the banquet. 5 Monday July 9th Monday Theatre 9th 8.30-9.00 9.00 - 9.30 9.30 - 10.00 10.00 - 10.30 10.30 - 11.00 11.00 - 11.30 11.30 - 12.00 12.00 - 12.30 12.30 - 1.00 1.00 - 2.00 2.00 - 2.30 2.30 - 3.00 3.00 - 3.30 PL1 PL2 PL3 PL4 I1 I2 Monday Cinema Monday Conference Room Monday Ensemble Monday Studio Lunch Lunch Lunch Lunch Lunch Van Hest Aldrich Session Harth I3 Klok I4 Coffee Posters Becer Bruker Session Yagci Theato Coffee Posters Vana Thielemans Lansalot Harth Theato Haddleton Agilent Session Welcome Hawker Frechet Stoddart Matyjaszewski I5 I6 Topham Klumperman Coffee Posters I7 I8 Topham I9 I10 Adams Davis I12 Reineke I13 4.05 - 4.20 4.20 - 4.35 4.35 - 4.50 C1 C2 C3 Tovar Bruns Tao C8 W Cheng C9 Lavignac C10 Hutchings C15 Bottle C16 Coelho C17 Roth C22 M Tang C23 Saito C24 Z Yang C29 Saunders C30 de Geest C31 Ramos 4.55 - 5.10 5.10 - 5.25 5.30 - 5.45 5.45 - 6.00 6.00-6.15 6.00 - 6.30 6.30-6.45 6.00 - 7.00 C4 C5 C6 C7 MacKenzie Pomposo Thornton T Smith C11 S Liu C12 Schacher C13 Goldmann C18 C19 C20 C21 C25 C26 C27 C28 C32 C33 C34 C35 Posters Posters Posters Posters Posters Posters Malmstrom Mantovani I11 Q Zhang Irvine Vana Simpson I14 Mantovani Fulton Coffee Posters 3.30 - 4.00 Posters Posters Posters Osborne Adams C Williams Coffee Posters Howse Cotanda Choudhury Thielemans Posters Posters Posters I15 Russell Lansalot Retsch Gortz Zhoa Posters Posters Posters 6 Tuesday July 10th 8.30-9.00 9.00 - 9.30 9.30 - 10.00 10.00 - 10.30 10.30 - 11.00 11.00 - 11.30 11.30 - 12.00 12.00 - 12.30 12.30 - 1.00 1.00 - 2.00 2.00 - 2.30 2.30 - 3.00 3.00 - 3.30 P6 P7 P8 P9 I16 I17 I18 I19 A1 A2 Tuesday Theatre 10th O'Reilly Lubrizol Session Aida Hillmyer Manners Wooley Coffee Schubert Weck Barner Kowollik Du Prez Lunch I20 I21 I22 I23 Howdle MG Award Session Cooper I36 Kinloch I37 Coffee Posters Tuesday Cinema Tuesday Conference Room Tuesday Ensemble Tuesday Studio Klumperman Klok Brocchini Polytherics Session Coffee Alexander Stenzel Lecommandoux Nicolas Lunch Bon Colloids Coffee Van Hest Armes Caruso Ngai Lunch Coffee Lutz Gibson Demirel Cameron Lunch I24 I25 I26 I27 McKeown Heise Pochan Coffee Posters Coffee Spatz Velonia Bulmus Schlaad Lunch I28 I29 I30 I31 Davis I38 I39 Heise Tew Maynard Coffee Posters I32 C I33 C I34 C I35 C Alexander I40 I41 I42 C I43 C 3.30 - 4.00 A3 Howdle MG Award Session Thompson I44 McKeown I45 Hoogenboom I46 Helms I47 Epps Colloids P Li 4.05 - 4.20 4.20 - 4.35 4.35 - 4.50 C36 C37 C38 H Wilson Novoa-Carballal H Xu C43 C44 C45 Edmondson Drockenmuller Spain C50 C51 C52 Basuki Whittell P Wilson C57 C58 C59 Bird Keddie Moatsou C64 C65 C66 Lovell Smeets Ballard 4.55 - 5.10 5.10 - 5.25 5.30 - 5.45 5.45 - 6.00 6.00-6.15 6.00 - 6.30 6.30-6.45 6.00 - 7.00 C39 C40 C41 C42 C49 Fors M Whittaker Daugaard Monge Pham Posters Posters Posters C46 C47 C48 D'Agosto Guillaume Kember C53 C54 C55 C56 C81 Garnier Bednarek Gautrot Billon Kempe Posters Posters Posters C60 C61 C62 C63 Schiller G Chen Behrendt Gianneschi C67 C68 C69 C70 Jaekle Louzao Pernas Blinco Rocha Posters Posters Posters Maynard Scherman M Meier Coffee Posters Meier Lovell Colloids Epps Zetterlund Coffee Posters Posters Posters Posters Posters Posters Posters 7 Wednesday July 11th 8.30-9.00 9.00 - 9.30 9.30 - 10.00 10.00 - 10.30 10.30 - 11.00 PL10 PL11 PL12 PL13 11.00 - 11.30 11.30 - 12.00 12.00 - 12.30 12.30 - 1.00 1.00 - 2.00 I48 I49 I50 I51 Wednesday Theatre 11th Dove Infineum Session Whitesides I Meijer Percec De Simone Coffee Wednesday Cinema Wednesday Conference Room Wednesday Ensemble Wednesday Studio Coffee Coffee Coffee Colloids Coffee Barner Kowollik Bourissou Perrier Becer Moad Lunch Lutz Howdle Kiick Sumerlin Pyun Lunch Excursions I52 I53 I54 I55 I56 I57 I58 I59 Excursions Cameron Grubbs S Rowan Bielaswski Becker Lunch I60 I61 I62 I63 Excursions Gibson DuBois Ayres Lowe Neto Lunch Excursions I64 C I65 C I66 C I67 C Armes Stevens Discher Charleux Asua Lunch Excursions Thursday July 12th Thursday Theatre 12th Becer I68 I69 I70 I71 CSIRO Session Jiang Sawamoto Coffee Kiick Brocchini Emrick Savin Heuts C72 Y Zheng PL14 PL15 Thursday Cinema I72 I73 I74 I75 C73 C74 Coffee Charleux Mahanthapa Tsarevsky Destarac Gohy Thurecht Ott Thursday Conference Room Coffee Fulton I76 Yamamoto I77 Hayward I78 G Chen I79 Pascual C75 Phan C76 Fernandez-Trillo I80 I81 I82 I83 C77 C78 Thursday Ensemble Thursday Studio Coffee Lowe Boyer Mathers Sanyal Sammon Colombani J Du Coffee Becker I84 Hamley I85 Groll I86 Harbron I87 Junkers C79 Ladmiral C80 Madsen 8 Monday July 9th Theatre Agilent session Chair: D.M. Haddleton 10.30-11.00 Professor Craig Hawker Materials Research Laboratory, UCSB PL1 Generating Complex Nanoscale Patterns through Bottom-up Self-Assembly 11.00-11.30 Professor Jean Frechet King Abdullah University of Science and Technology PL2 Northwestern University PL3 Functional macromolecules in energy conversion. 11.30-12.00 Professor Fraser Stoddart Positive Cooperativity in the Template-Directed Synthesis of Monodisperse Macromolecules 12.00-12.30 Professor Krzysztof Matyjaszewski Carnegie Mellon PL4 Vanderbilt University I1 ATRP under biorelevant conditions Aldrich Session Chair: J.C.M. Van Hest 2.00-2.30 Professor Eva Harth Functionalized Polyester and Glycidol Polymers with Control in Branching: Synthesis of Monomers and Supramolecular Network Formation. 2.30-3.00 Professor Harm-Anton Klok Ecole Polytechnique Fédérale de Lausanne (EPFL) I2 Interactive and responsive polymer brushes prepared via surface-initiated polymerization Chair: E.M. Harth 3.30-4.00 Professor Thomas Davis Aus. Centre for NanoMedicine and CAMD, UNSW I11 New Synthesis of Biodegradable Nanoparticles based on Dextran 4.05-4.20 Dr Tim Smith Lubrizol Ltd C1 University of Basel, Department of Chemistry C2 Leading polymer development for the lubricants industry 4.20-4.35 Dr Nico Bruns ATRPases: Enzymes that catalyze atom transfer radical polymerization 4.35-4.50 Dr Lei Tao Tsinghua University C3 Eindhoven Technical University C71 Self-healing hydrogels for bio-applications 4.55-5.10 Dr Beulah McKenzie Complex Polymeric Bicontinuous Nanospheres as Templates for Mineralization 9 5.10-5.25 Professor Jose A. Pomposo University of the Basque Country C5 Durham University C6 Single-Chain Nanoparticles via "Self-Click" Chemistry 5.30-5.45 Dr Paul Thornton The Highly Controlled Synthesis of High Molecular Weight Star Shaped Polypeptides via NCA Ring Opening Polymerisation (NCA ROP) from a Dendritic Core. 5.45-6.00 Professor J. D. Tovar C7 Johns Hopkins University Nano- and macrostructures derived from the supramolecular polymerization of pi-conjugated self-assembling peptides 6.00 – 6.15 Dr Sarah Hehir C14 Durham University Peptide-Based Nanomaterials from N-Carboxyanhydrides Cinema Monday July 9th Bruker Session Chair: C.R. Becer 2.00-2.30 Professor Yusuf Yagci Istanbul Technical University I3 Univ. of Hamburg, Inst. Tech. and Macromol. Chem. I4 Macromolecular synthesis by photochemical methods 2.30-3.00 Professor Patrick Theato New ways of installing single reactive groups along a polymer chain or at the chain end Chair: P. Theato 3.30-4.00 Professor Theresa Reineke University of Minnesota I12 Core-Shell Carbohydrate-Based Block Copolymers Designed for Biological Delivery 4.05-4.20 Professor Wenlong Cheng Monash University C8 Novel Reusable Reversible Polymer via Solid-state Topochemical Polymerization 4.20-4.35 Dr Nathalie Lavignac Medway School of Pharmacy C9 Department of Chemistry, Durham University C10 Poly(disulfide amine) for nucleic acid delivery 4.35-4.50 Dr Lian Hutchings Synthesis of model branched polymers - the advantages of the macromonomer approach 4.55-5.10 Professor Shiyong Liu University of Science & Technology of China C11 Caged Polyelectrolytes: Stimuli-Triggerable Charge-Generation Polymers (CGPs) and Functional Materials 5.10-5.25 Professor Felix Schacher Friedrich-Schiller-University Jena C12 Hierarchical Self-Assembly of Star-Shaped Organometallic Crystalline-Coil Block Copolymers in Solution 10 5.30-5.45 Dr Anja Goldmann C13 Karlsruhe Institute of Technology (KIT) Tailored surface modification of biosubstrates Conference Room Monday July 9th Chair: P. Vana 2.00-2.30 Dr Paul Topham Aston University I5 Stellenbosch University I6 Revolymer Ltd I13 Queensland University of Technology C15 Polymer-Peptide Biohybrids 2.30-3.00 Professor Bert Klumperman Hierarchical Self-Assembly of Poly(Aryl-Triazole)s Chair: P. Topham 3.30-4.00 Dr Victoria Osborne The Science behind Rev7 – The Removable Chewing Gum 4.05-4.20 Professor Steven Bottle Fluorescence Switch On With Profluorescent Nitroxides in Epoxy Resins On Cure 4.20-4.35 Dr Jorge Coelho University of Coimbra C16 Controlled/”Living” Radical Polymerization of non-activated monomers - industrial perspectives for poly(vinyl chloride) 4.35-4.50 Dr Gregory Saunders Agilent C17 Gel Permeation Chromatography of Polymers under Extreme Conditions 4.55-5.10 Mr Qiang Zhang University of Warwick C18 Highly sequence controlled multiblock glycopolymers via Cu(0)-mediated radical polymerizations (SET-LRP) 5.10-5.25 Dr Derek Irvine University of Nottingham C19 Investigation into the Mechanism of Microwave Induced Rate Enhancements in Chain Growth Polymerisation 5.30-5.45 Professor Philipp Vana Univ. of Goettingen - Institute of Physical Chemistry C20 Gold nano-particles and multi-block copolymers from RAFT – a love story 5.45-6.00 Dr Peter Roth CAMD, University of New South Wales C21 UCST-type behaviour of POEGMA in alcohols: Structure Dependence and Applications 11 Ensemble Monday July 9th Chair: W. Thielemans 2.00-2.30 Dr Dave Adams University of Liverpool I7 Dr Charlotte Williams Imperial College London I8 Dipeptide-based Gelators 2.30-3.00 Catalytic activation of renewable resources in polymer synthesis Chair: D.J. Adams 3.30-4.00 Professor Eva Malmström KTH Fiber and polymer technology I14 Telechelic macromonomers by enzyme-catalyzed polymerization for thin film applications 4.05-4.20 Dr Min Tang Imperial College London C22 Synthesis and Characterization of various copolymers from a carbohydrate lactone and their applications in medicine and in cellulose nanocomposites 4.20-4.35 Dr Kei Saito Monash University C23 Novel Reusable Reversible Polymer via Solid-state Topochemical Polymerization 4.35-4.50 Ms Zhongqiang Yang Tsinghua University C24 University of Sheffield C25 University of Warwick C26 The assembly and functions of DNA-dendron hybrid 4.55-5.10 Dr Jonathan Howse In-situ Studies of Spin Coating of Polymer Blends 5.10-5.25 Pepa Cotanda Functionalized organocatalytic nanoreactors: hydrophobic pockets for acylation reactions in water 5.30-5.45 Professor Saad Uddin Choudhury Cotton College State University C27 University of Nottingham C28 Green Composites from Waste Materials 5.45-6.00 Dr Wim Thielemans Surface-initiated polymerisation from cellulose nanocrystals 12 Studio Monday July 9th Chair: M. Lansalot 2.00-2.30 Dr Giuseppe Mantovani University of Nottingham I9 Newcastle University I10 Intelligent polymeric nanocarriers for anticancer therapy 2.30-3.00 Dr David Fulton Introducing Stimuli Responsiveness Into Polymeric Nanoparticles with Dynamic Covalent Bonds Chair: G. Mantovani 3.30-4.00 Professor Thomas Russell University of Massachusetts I15 From Ultradense Arrays of Nanodots to Nanolines: A Route to Addressable Media 4.05-4.20 Dr Brian Saunders University of Manchester C29 One-step preparation of uniform cane-ball shaped water-swellable microgels 4.20-4.35 Dr Bruno De Geest Ghent University C30 Synthetic vaccines - mimicing microbial structure and function 4.35-4.50 Dr Jose Ramos University of the Basque Country UPV/EHU C31 PVCL-based biocompatible nanogels for biomedical applications 4.55-5.10 Dr Muriel Lansalot CNRS - C2P2 C32 Batch RAFT emulsion polymerization mediated by poly(methacrylic acid) macroRAFT agents: one-pot synthesis of selfstabilized particles 5.10-5.25 Dr Markus Retsch University of Bayreuth C33 Optical and Mechanical Properties of Hollow Silica Nanoparticles 5.30-5.45 Dr Verena Gortz University Of York C34 Monodisperse Liquid Crystal Elastomer Particles by Dispersion Polymerisation 5.45-6.00 Professor Hanying Zhao Nankai University C35 Self-assembly of Gold Nanoparticles at Liquid-Liquid Interface and Fabrication of Polymer-Gold nanoparticles Ordered Structures 13 Tuesday July 10th Theatre Lubrizol Session Chair: R.K. O’Reilly 8.30-9.00 Professor Takuzo Aida Dept. of Chemistry and Biotechnology, The University of Tokyo PL6 Functional 'Aqua' Materials -- Development and Applications 9.00-9.30 Professor Marc Hillmyer University of Minnesota PL7 Nanostructured membranes and monoliths from reactive multifunctional block polymers 9.30-10.00 Professor Ian Manners University of Bristol PL8 Functional Nanomaterials via Crystallization-Driven “Living Self-Assembly" 10.00-10.30 Professor Karen Wooley Texas A&M University PL9 Nanoscopic polymer objects of unique shapes and morphologies and well-defined structures and dimensions as controlled drug delivery devices Chair: R.K. O’Reilly 11.00-11.30 Professor Ulrich S Schubert Freidrich-Schiller-University Jena I16 Electrical energy storage: How polymers can replace cobalt and enable printable batteries 11.30-12.00 Professor Marcus Weck New York University I17 Polymer-Supported Catalysis: Synergy Between Catalytic Mechanism and Polymer Design 12.00-12.30 Professor Christopher Barner-Kowollik Karlsruhe Institute of Technology (KIT) I18 Pericyclic Reactions for High Resolution (Bio)Surface Design 12.30-1.00 Professor Filip Du Prez Ghent University I19 One-pot multistep reactions based on thiolactones: extending the realm of thiol-ene chemistry in polymer synthesis Macro Group UK Award Session Chair: S. Howdle 2.00-2.30 Professor Andrew Cooper University of Liverpool A1 Functional Conjugated Microporous Polymers - Sorption, Catalysis and Separation 2.30-3.00 Dr Ian Kinloch University of Manchester A2 Low Dimension Carbons as Functional Fillers and Reinforcements in Polymer Composites 14 Macro Group Award Session Chair: S. Howdle 3.30-4.00 Ms Kate Thompson A3 The University of Sheffield Stabilisation of Pickering emulsions using sphere, worm and vesicle nanoparticles prepared by RAFT aqueous dispersion polymerisation 4.05-4.20 Dr Jonathan Henry Wilson C36 Merck Chemicals Ltd One-Step Synthesis of Shape and Optically Anisotropic Polymer Particles 4.20-4.35 Dr Ramon Novoa-Carballal C37 University of Bayreuth Synthesis of Polysaccharide-b-PEG Block Copolymers by Oxime Click and their use for the formation of interpolyelectrolyte nanogels 4.35-4.50 Dr Huaping Xu C38 Tsinghua University Selenium-containing Polymers: from Molecular Design to Controlled Self-assembly and Disassembly 4.55-5.10 Dr Brett Fors C39 University of California Development of a Photo-Controlled Living Radical Polymerization Process 5.10-5.25 Dr Michael Whittaker Centre for Advanced Macromolecular Design (CAMD), UNSW C40 Living Free Radical Polymerisation in the Presence of Cu(0): Towards Biological Precision 5.30-5.45 C41 Dr Anders Egede Daugaard Technical University of Denmark A Platform for Functional Conductive Polymers 5.45-6.00 Dr Sophie Monge Thermosensitive and complexing copolymers for water treatment 6.00-6.15 Institut Charles Gerhardt - Equipe IAM - Université Montpellier poly(N-n-propylacrylamide)-b-poly((dimethylphosphoryl)ethyl Dr Phuoc Dien Pham C42 acrylamide) Institut Charles Gerhardt - Equipe IAM- Université Montpellier block C49 Oligomerization of Glycerol-Based Monomers and Functionalization Tuesday July 10th Cinema Chair: E. Klumperman 11.00-11.30 Dr Jean-François Lutz Institut Charles Sadron I20 Synthetic Polymers with Controlled Primary Structures: Design, Folding and Function 11.30-12.00 Dr Matthew Gibson Warwick University, Department of Chemistry I21 Interfacing Materials with Biology: Glycoprotein Mimics and Smart Materials 12.00-12.30 Professor A. Levent Demirel Koç University I22 Self-Assembly of Macromolecules into Nanostructures in Solution 12.30-1.00 Professor Neil Cameron Durham University I23 Porous Polymers by Emulsion Templating 15 Chair: N. McKeown 2.00-2.30 Dr Andreas Heise Dublin City University (DCU) I36 University of Delaware I37 Synthetic polypeptides as functional (bio)materials 2.30-3.00 Professor Darrin Pochan Multicompartment/Multicomponent Micelles with Block Copolymer Blending through Kinetic Control of Solution Assembly Chair: A. Heise 3.30-4.00 Professor Neil McKeown I44 Cardiff University New tricks with an old bicycle: Microporous polymers prepared by the formation of Tröger's base 4.05-4.20 Dr Steve Edmondson Department of Materials, Loughborough University C43 ARGET ATRP and Polydopamine Initiators for Versatile Polymer Brush Growth 4.20-4.35 Professor Eric Drockenmuller C44 University of Lyon Polymers from renewable resources and robust, efficient and orthogonal chemistries 4.35-4.50 Dr Sebastian Spain C45 University of Nottingham Development of immunostimulatory polymers for vaccine adjuvants 4.55-5.10 Dr Franck D'Agosto C46 CNRS Preparation of polyethylene (PE) bearing functional chain ends and their use for the design of original PE based materials. 5.10-5.25 Professor Sophie Guillaume Institut des Sciences Chimiques de Rennes, Univ. de Rennes C47 alpha,omega-Dihydroxytelechelic Poly(Trimethylene Carbonate)s: Valuable Precursors to Polyester-b-Polycarbonate and to Non-Isocyanate Poly(Carbonate Urethane)s 5.30-5.45 Dr Michael Kember C48 Imperial College London New Catalysts for epoxide/CO2 copolymerisation: Evidence for a dinuclear mechanism? Tuesday July 10th Conference Room Chair: H.-A. Klok 11.00-11.30 Professor Joachim Spatz Max Planck Institute & Univ. of Heidelberg I24 Dept. of Mat. Sci. and Tech., Univ. of Crete I25 Functional Polymer Interfaces for Switching Cell Fate 11.30-12.00 Professor Kelly Velonia In Situ Hierarchical Formation of Giant Amphiphile nanocarriers, nanocontainers, nanoreactors. 12.00-12.30 Professor Volga Bulmus Izmir Institute of Technology I26 Stimulus-sensitive polymer bioconjugates for nanomedicine applications 12.30-1.00 Dr Helmut Schlaad Max Planck Institute of Colloids and Interfaces I27 Functionalization of Polypeptides via Thiol-X Photochemistry Chair: T.P. Davis 16 2.00-2.30 Professor Gregory Tew Univ. of Massachusetts, Amherst Dept. of Polym. Sci. and Eng. I38 Designing Polymers with Strong Similarity to Biology 2.30-3.00 Professor Heather Maynard I39 University of California at Los Angeles Polymers That Stabilize Proteins and Protein Conjugates to Environmental Stressors Chair: H.A. Maynard 3.30-4.00 Professor Richard Hoogenboom Ghent University I45 Australian Centre for Nanomedicine, UNSW C50 Poly(2-oxazoline)s and beyond 4.05-4.20 Johan Sebastian Basuki Versatile Multi-functionalization of Magnetic Nanoparticles for Biomedical Applications 4.20-4.35 Dr George Whittell C51 Univ. of Bristol, School of Chemistry Solution phase self-assembly of polyferrocenylsilane-containing triblock co-polymers 4.35-4.50 Dr Paul Wilson C52 University of Warwick Polymer Logistics; Smart Polymers for Cargo Transport and Triggered Release. 4.55-5.10 C53 Professor Gill Garnier Polyelectrolytes to engineer biodiagnostics 5.10-5.25 Dr Melania Bednarek Center of Molecular and Macromolecular Studies, PAS C54 Functionalized polylactides by cationic polymerization 5.30-5.45 Dr Julien Gautrot Queen Mary University of London C55 Micro-patterned polymer brushes for cell-based assays: from cell shape to micro-tissue assembly 5.45-6.00 Professor Laurent Billon IPREM EPCP C56 Glycopolymers synthesized by RAFT and NMP for Lectin Recognizable Biomaterials 6.00-6.15 Dr Kristian Kempe Friedrich-Schiller-Universität Jena C81 Tuesday July 10th Ensemble Polytherics Session Chair: S. Brocchini 11.00-11.30 Professor Cameron Alexander University of Nottingham I28 Varying polymer structures for delivering drugs and recognising cell signals 11.30-12.00 Professor Martina Stenzel University of New South Wales I29 Development of a drug delivery system for platinum drugs 12.00-12.30 Professor Sebastien Lecommandoux Université de Bordeaux I30 Smart Polymersomes: from Biomimicry to Smart Drug Delivery 17 12.30-1.00 Dr Julien Nicolas Univ. Paris-Sud I31 Dual Active Targeting Using a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease Chair: C. Alexander 2.00-2.30 Dr Oren Scherman University of Cambridge I40 Cucurbiturils at the Interface between Supramolecular Chemistry and Materials Science 2.30-3.00 Professor Michael Meier Karlsruhe Institute of Technology (KIT) I41 Plant oils: The perfect renewable resource for polymer science? Chair: M.A. Meier 3.30-4.00 Dr Brett Helms The Molecular Foundry - Lawrence Berkeley National Lab. I46 A polymer approach to nanocrystal-based electroactive layers with tailored architectures for advanced energy applications 4.05-4.20 Dr Matthew Bird PolyTherics Ltd C57 CSIRO Materials Science and Engineering C58 TB The Importance of Homogeneity in PEGylated Biologics 4.20-4.35 Dr Daniel Keddie The Effect of the Acid/Base "Switchable" Dithiocarbamate Z-Group Substituent on RAFT Polymerization 4.35-4.50 Dafni Moatsou University of Warwick C59 Monash University C60 Polymer-functionalized Janus silica particles 4.55-5.10 Dr Tara Schiller Photo-initiation for the in-situ formation of hybrid silica-vinyl networks 5.10-5.25 Professor Gaojian Chen Soochow University C61 Novel Boron-containing Vesicles for BNCT, Controlled Drug Release and Diagnostic Imaging 5.30-5.45 Dr Jonathan Behrendt The University of Manchester C62 University of California, San Diego C63 Fluorescent Nanoparticles from PEGylated Polyfluorenes 5.45-6.00 Professor Nathan Gianneschi Programming the Morphology of Nanoparticles with Peptides, DNA and Enzymes 18 Tuesday July 10th Studio - Colloids Chair: S.A.F. Bon 11.00-11.30 Professor Jan van Hest Radboud University Nijmegen I32 University of Sheffield I33 The University of Melbourne I34 Functional Polymersomes via Kinetic Control 11.30-12.00 Professor Steven Armes RAFT Aqueous Dispersion Polymerisation 12.00-12.30 Professor Frank Caruso Engineered Polymer Films and Particles Designed to Interface with Biology 12.30-1.00 Dr To Ngai The Chinese University of Hong Kong I35 University of Delaware I42 Microgels at the oil-water interfaces Chair: P.A. Lovell 2.00-2.30 Professor Thomas Epps Designer Nanoscale Materials: Interfacial Manipulations in Block Copolymer Systems 2.30-3.00 Professor Per Zetterlund The University of New South Wales I43 Miniemulsion Polymerization Using Graphene Oxide as Sole Surfactant Chair: T.H. Epps 3.30-4.00 Professor Pei Li The Hong Kong Polytechnic University I47 Formation of Nanostructured Materials Using Amphiphilic Hollow Particles as Novel Building Blocks 4.05-4.20 Professor Peter Lovell University of Manchester C64 A New Nitroxide for Nitroxide-Mediated Polymerisation at Temperatures Below 100 °C 4.20-4.35 Dr Niels M.B. Smeets McMaster University C65 Hyperbranched Polymers synthesized from Catalytic Chain Transfer Polymerization for Macromolecular Design 4.35-4.50 Nicholas Ballard University of Warwick C66 Rutgers University – Newark C67 Anisotropic Particles as Surfactants 4.55-5.10 Professor Frieder Jaekle Self-Assembled Nanostructures of Luminescent Organoboron Block Copolymers and Star Polymers 5.10-5.25 Dr Iria Louzao Pernas Institute for Molecules and Materials, Radboud University C68 Permeability effects in polymersome-based artificial organelles 5.30-5.45 Dr James Blinco Queensland University of Technology C69 The Design of Profluorescent Nitroxide Based Sensor Materials 5.45-6.00 Dr Nuno Rocha Chemical Engineering Department, University of Coimbra C70 Development of stimuli-responsive hybrid nanoparticles for advanced coatings, based on an ABCD type block copolymer. 19 Wednesday July 11th Theatre Infineum Session Chair: A.P. Dove 8.30-9.00 Professor George Whitesides Harvard University PL10 University of Technology Eindhoven PL11 New Problems for Polymer Scientists 9.00-9.30 Professor Egbert Meijer Non-covalent Synthesis of Functional Supramolecular Systems 9.30-10.00 Professor Virgil Percec PL12 University of Pennsylvania New Synthetic Methods for Macromolecular and Supramolecular Synthesis 10.00-10.30 Professor Joseph DeSimone University of North Carolina at Chapel Hill PL13 Co-opting Moore’s Law: Vaccines, Medicines and Interfacially-Active Particles Made on a Wafer Chair: C. Barner-Kowollik 11.00-11.30 Dr Didier Bourissou I48 University of Toulouse Tailor-made Biodegradable Polymers: New Preparation Routes and Applications in Drug Delivery Systems 11.30-12.00 I49 Professor Sebastien Perrier Key Centre for Polymers & Colloids, Univ. of Sydney Using Molecular Engineering to build Nanostructured Materials 12.00-12.30 Dr Remzi Becer University of Warwick I50 CSIRO I51 Synthesis of glycopolymers and their interactions with lectins 12.30-1.00 Dr Graeme Moad The Scope for RAFT Single Unit Monomer Insertion Wednesday July 11th Cinema Chair: J.F. Lutz 11.00-11.30 Professor Steve Howdle University of Nottingham I52 Supercritical Fluids: A Dispersion Polymerisation Route to Nanostructured Block Copolymer Microparticles 11.30-12.00 Professor Kristi Kiick University of Delaware I53 Biopolymeric conjugates as injectable cardiovascular therapeutics 12.00-12.30 Professor Brent Sumerlin Southern Methodist University I54 Dynamic-covalent branched polymer assemblies 20 12.30-1.00 Professor Jeffrey Pyun I55 University of Arizona Elemental Sulfur: A novel feedstock for polymers and nanomaterials Wednesday July 11th Conference Room Chair: N.R. Cameron 11.00-11.30 Professor Robert B Grubbs Stony Brook University I56 Case Western Reserve University I57 From copolymers to functional materials 11.30-12.00 Professor Stuart Rowan Using the Dynamic Bond to Access Macroscopically Stimuli-Responsive Materials 12.00-12.30 Professor Christopher Bielawski I58 University of Texas at Austin Beyond the Thermal Limit: Twisting & Stretching Molecules Using Mechanical Force 12.30-1.00 Professor Matthew Becker I59 The University of Akron Degradable, Amino Acid-based Poly(ester urea)s for Bone Defect Repair Wednesday July 11th Ensemble Chair: M.I. Gibson 11.00-11.30 Professor Philippe Dubois University of Mons – UMONS I60 From synthesis of biobased polymers by reactive extrusion to high performance durable materials 11.30-12.00 Dr Neil Ayres University of Cincinnati I61 Polymer synthesis incorporating N-alky urea peptoid oligomers 12.00-12.30 Professor Andrew Lowe Centre for Advanced Macromolecular Design, UNSW I62 Thiol-Michael Coupling in Advanced Polymer Synthesis 12.30-1.00 Dr Chiara Neto The University of Sydney I63 Functional patterned surface coatings by dewetting of thin polymer films 21 Wednesday July 11th Studio Chair: S.P. Armes 11.00-11.30 Professor Molly Stevens Imperial College London I64 New biomaterials-based approaches for tissue regeneration and biosensing 11.30-12.00 Professor Dennis Discher Univ. Pennsylvania I65 From self-assembly to self-recognition with nanobio-polymers 12.00-12.30 Professor Bernadette Charleux University Claude Bernard Lyon I66 Rules that determine the final morphology of poly(methacrylic acid-co-PEO methacrylate)-b-polystyrene block copolymer nanoobjects formed in situ by polymerization-induced micellization in water or in water/ organic cosolvent media. 12.30-1.00 Professor José M Asua POLYMAT, University of the Basque Country I67 Opportunities offered by photopolymerization in continuous tubular reactors for the production of waterborne dispersions 22 Thursday July 12th Theatre CSIRO Session Plenary Lecture Session Chair: C.R. Becer 9.00-9.30 Professor Ming Jiang PL14 Fudan University Hybrid Inclusion Complex (HIC) and its Key Role in Constructing New Polymeric Materials 9.30-10.00 Professor Mitsuo Sawamoto Kyoto University PL6 UCL School of Pharmacy and PolyTherics I68 University of Massachusetts I69 Perspective of Precision Radical Polymerization Chair: K.L. Kiick 10.30-11.00 Professor Steve Brocchini Conjugation of polymers to proteins by bis-alkylation 11.00-11.30 Professor Todd Emrick Functional hydrophilic and amphiphilic polymers tailored for encapsulation and delivery. 11.30-12.00 Professor Daniel Savin The University of Southern Mississippi I70 Solution Self-assembly and Responsiveness in Polypeptide-based Block and Star Copolymers 12.00-12.30 Dr Hans Heuts Eindhoven University of Technology I71 Network of Excellence for Functional Biomaterials C72 Exploring the Chemistry of CCT-Derived Macromonomers 12.30-12.45 12.45-1.00 Dr Yu Zheng Single cyclized polymer: Beyond Flory-Stockmayer theory Thursday July 12th Cinema Chair: B. Charleux 10.30-11.00 Professor Mahesh Mahanthappa University of Wisconsin–Madison I72 Molecular Heterogeneity in Self-Assembly: Is Monodispersity Necessary? 11.00-11.30 Professor Nicolay Tsarevsky Southern Methodist University I73 Hyperbranched Polymers with Precisely Placed Functional Groups via ATRP and Conventional Radical Polymerization in the Presence of Efficient Chain Transfer Agents: Synthesis and Applications 23 11.30-12.00 Professor Mathias Destarac University Paul Sabatier, Toulouse I74 RAFT/MADIX-derived hydrophilic/CO2-philic diblock copolymers: synthesis and solubility in supercritical carbon dioxide 12.00-12.30 Professor Jean-François Gohy Catholic University of Louvain I75 AIBN C73 CSIRO Materials Science and Engineering C74 Nanomaterials from photocleavable block copolymers 12.30-12.45 Dr Kristofer Thurecht Hyperbranched polymers for polymer tharanostics 12.45-1.00 Dr Christina Ott Synthesis and Characterization of "Glycopolyurethanes” Thursday July 12th Conference Room Chair: D.A. Fulton 10.30-11.00 Dr Takuya Yamamoto I76 Tokyo Institute of Technology Formation of a Micelle from an Amphiphilic Cyclic Block Copolymer and Determination of the Stability 11.00-11.30 University of Massachusetts Amherst I77 Department of Macromolecular Science, Fudan University I78 Professor Ryan Hayward Patterning growth with photo-crosslinkable copolymer films 11.30-12.00 Dr Guosong Chen Polymeric vesicles mimicking glycocalyx (PVGs) for studying carbohydrate-protein interactions in situ by dynamic light scattering 12.00-12.30 Dr Sagrario Pascual Université du Maine - Institut des Molécules et Matériaux du Mans I79 Well-defined amine-reactive polymers: synthesis and reactivity 12.30-12.45 Dr Trang Phan Aix-Marseille University - Institut de Chimie Radicalaire C75 Free-Standing Nanoporous Materials based on Self-assembled ABA Block Copolymer Micelles 12.45-1.00 Dr Francisco Fernandez-Trillo School of Pharmacy, University of Nottingham C76 Responsive Polymers for Simultaneous Interference with Bacterial Quorum Sensing and Adhesion Thursday July 12th Ensemble Chair: A.B. Lowe 10.30-11.00 Dr Cyrille Boyer Centre for Advanced Macromolecular Design; UNSW I80 Design of Biodegradable Polymeric Nanoparticles for Delivery of Nitric Oxide. A New Hope for Multi-Drug Resistance in Cancer Treatment 11.00-11.30 Professor Robert Mathers Penn State University I81 Cascade Strategies for Polymerizing Renewable Diene Monomers 11.30-12.00 Professor Amitav Sanyal Bogazici University I82 24 Orthogonally Functionalizable Polymeric Materials 12.00-12.30 Dr Chris Sammon I83 Sheffield Hallam University The development of fully injectable hydrogels for the treatment of degenerative disc disease 12.30-12.45 Dr Olivier Colombani PRES LUNAM, Université du Maine C77 Tongji University C78 Frozen to dynamic self-assembled block copolymers 12.45-1.00 Professor Jianzhong Du Design and synthesis of multifunctional polymeric nanoparticles Thursday July 12th Studio Chair: M. Becker 10.30-11.00 Professor Ian Hamley University of Reading I84 University of Würzburg I85 Self-Assembly of Amyloid Peptide/Polymer Conjugates 11.00-11.30 Professor Jürgen Groll Specifically Interacting Biointerfaces 2D vs. 3D: Cell Adhesion and Immune Response 11.30-12.00 Ms Rachel Harbron Imperial College London I86 Responsive polymer-stabilised emulsion droplets: New properties and performance 12.00-12.30 Professor Thomas Junkers Universiteit Hasselt I87 Radical Coupling: Access to midchain functionalized chains 12.30-12.45 Dr Vincent Ladmiral C79 University Of Sheffield Glycopolymer-stabilized nanostructures by aqueous RAFT dispersion polymerisation 12.45-1.00 Dr Jeppe Madsen University of Sheffield C80 Biodegradable stimulus-responsive block copolymers prepared from disulfide-functional cyclic monomers 25 ABSTRACTS 26 PLENARY LECTURES PL1 Generating Complex Nanoscale Patterns through Bottom-up Self-Assembly Professor Craig Hawker Materials Research Laboratory The self-assembly of block copolymers is a promising platform for the “bottom-up” fabrication of nanostructured materials and devices. In designing such nanostructures, the molecular characteristics and functional groups of the block copolymers dictate the self-assembly process and are therefore critical in the formation of various structures. This feature will be illustrated with examples ranging from new strategies for the fabrication of advanced microelectronic devices to novel hydrogels and surface coating inspired by marine organisms. PL2 Functional macromolecules in energy conversion. Two series of oligorotaxanes that contain –CH2NH2+CH2– recognition sites in their dumbbell components have been synthesized employing template-directed protocols. [24]Crown8 rings self-assemble by a clipping strategy around each and every recognition site using equimolar amounts of 2,6pyridinedicarboxaldehyde and tetraethyleneglycol bis(2aminophenyl) ether to efficiently provide up to a [20]rotaxane. In one series, the –NH2+– recognition sites are strategically positioned 3.5 All of the isolated rigid rod-like rotaxanes were pure and monodisperse, despite being constructed from up to 39 individual components. The stepwise yield for imine bond formation in the rigid rod-like rotaxanes was shown to be 99.9%. This maintenance of reaction efficiency can be ascribed to positive cooperativity, that is, when one ring is formed it aids and abets the formation of subsequent rings presumably because of stabilizing extended pi-pi stacking interactions between the arene units. The extended pi-pi stacking interactions in the rigid rod-like series were found to be present in the solid-state structures of the [3]- and [4]rotaxanes; molecular mechanics calculations performed on the entire series of oligomers led to a similar conclusion. In contrast, characterization of the conformationally flexible rotaxanes revealed no cooperativity in their formation. PL4 Professor Jean Frechet King Abdullah University of Science and Technology (KAUST) The design of organic macromolecules for applications in energy conversion is explored. For example organic polymers or blends of polymers and small molecules are attractive for the conversion of light into energy, or energy into light. Therefore, site isolation of light emitting chromophores within block copolymers1 or discrete organic nanoparticles may be used to create organic white light emitting diodes based on a single multichromophoric organic layer. Similarly, light absorbing conjugated macromolecules may be designed for application in photovoltaics. In this instance molecules capable of transporting electrons must be combined with hole transporting molecules in blends for which the required critical control of phase morphology is achieved through molecular design. PL3 Positive Cooperativity in the Template-Directed Synthesis of Monodisperse Macromolecules Professor Fraser Stoddart, Matthew E. Belowich, Cory Valente, Ronald A. Smaldone, Douglas C. Friedman, Johannes Thiel, Leroy Cronin Northwestern University ATRP under biorelevant conditions Professor Krzysztof Matyjaszewski Carnegie Mellon Atom Transfer Radical Polymerization (ATRP) under biorelevant conditions will be presented. PL5 Supramolecular Polymerization Driven by Host-Enhanced Noncovalent Interactions Professor Xi Zhang Tsinghua University Supramolecular polymers are defined as polymeric arrays of monomeric units that are brought together by reversible and highly directional secondary interactions. Although multiple hydrogen bonding has been widely used to drive supramolecular polymerization, we have demonstrated that host-enhanced charge transfer interactions, which possess a high binding constant and orientation selectivity, can be used to construct a supramolecular polymer as well. For this purpose, we have designed and synthesized a multifunctional monomer, containing anthracene-viologen-viologen-anthracene, that is 27 able to form multiple host-enhanced charge transfer interactions. This kind of molecular design can avoid the formation of cyclic species and dimerization. Then supramolecular polymers are formed simultaneously by mixing the multifunctional monomer with cucurbit[8]uril in water. We have shown that the similar concept can be extended to enhance pi-pi interaction and developed a method for supramolecular polymerization on the basis of host-enhanced pi-pi interactions. Therefore, this study enriches the field of supramolecular polymerization with new building blocks and driving. In addition, it is expected to be used a new effective method for fabricating supramolecular materials. PL6 Functional 'Aqua' Materials -- Development and Applications Professor Takuzo Aida Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo Here we report that water and clay (2-5%), upon mixing with a minute amount of a dendritic molecular glue carrying multiple guanidinium ion pendants (< 0.15%), quickly form a transparent hydrogel. This material can be molded into shape-persistent freestanding objects owing to its high mechanical strength, and instantaneously self-heals when destroyed. Furthermore, it preserves biologically active proteins for catalysis. The lecture will highlight some new advances and applications. PL7 Nanostructured membranes and monoliths from reactive multifunctional block polymers Professor Marc Hillmyer University of Minnesota Block polymers can adopt various ordered morphologies with compositional heterogeneities on the nanometer length scale. Selective removal of one block from such structures leads to nanoporous materials that hold tremendous promise in various patterning, separations, and templating applications. Methods for the preparation of mechanically robust nanoporous materials with controlled structures from multicomponent block polymers containing reactive functional groups will be discussed. PL8 Functional Nanomaterials via Crystallization-Driven “Living Self-Assembly" Professor Ian Manners University of Bristol Although chemical synthesis has evolved to a relatively advanced state, the ability to prepare well-defined selfassembled materials of controlled shape, size, and structural hierarchy is still in its relative infancy and currently remains the virtually exclusive domain of biology. In this talk the development of a promising new route to such materials, termed “crystallization-driven living self-assembly”, will be described. This approach was discovered as a result of investigation of the solution self-assembly behavior of block copolymers with crystalline polyferrocenylsilane metalloblocks in collaborative work with Mitch Winnik in Toronto. It offers an interesting and potentially powerful new route to well-defined micelles and hierarchical materials with controlled dimensions and a variety of potential applications and appears to be extendable to a wide range of different crystalline core-forming blocks, including biorelevant and pi-conjugated materials. PL9 Nanoscopic polymer objects of unique shapes and morphologies and well-defined structures and dimensions as controlled drug delivery devices Professor Karen Wooley Texas A&M University This presentation will describe our work over several years to tune the assembly and chemical transformations of di- and triblock graft copolymers into unique bio-functional nanostructures, with emphasis on our most recent efforts that have revealed the exquisite levels of control over drug packaging and release that originate from precisely-defined compositions, structures, dimensions and morphologies. Applications for these nanoscopic materials in the treatment of lung infectious diseases, acute lung injury and cancer will be highlighted. 28 PL10 PL12 New Synthetic Methods for Macromolecular and Supramolecular Synthesis New Problems for Polymer Scientists Professor George Whitesides Professor Virgil Percec Harvard University This talk will summarize research research in several areas— nanofabrication, cell biology, soft robotics, low-cost diagnostics—that use polymers and polymer science, and outline emerging applications that are limited by the availability of appropriate polymers. It is, thus, a talk concerned with currently unsatisfied needs and potential applications in polymer science, rather than a summary of completed research. PL11 Non-covalent Synthesis of Functional Supramolecular Systems Professor Egbert Meijer University of Technology Eindhoven The intriguing prospects of molecular electronics, nanotechnology, biomaterials, and the aim to close the gap between synthetic and biological molecular systems are important ingredients to study the cooperative action of molecules in the self-assembly towards functional complex molecular systems. The design and synthesis of well-defined supramolecular architectures requires a balanced choice between covalent synthesis and the self-assembly of the fragments prepared. The current self-assembly processes are primarily controlled by solvent, temperature or concentration. For synthetic chemists, the non-covalent synthesis of these supramolecular architectures is regarded as one of the most challenging objectives in science: How far can we push chemical self-assembly and can we get control over the kinetic instabilities of the non-covalent architectures made? How can we go from self-assembly to self-organization? In the lecture, a few outlines of these challenges will be given using a number of examples out of our own laboratories, with the aim to come to new strategies for multi-step non-covalent synthesis of functional supramolecular systems. University of Pennsylvania New synthetic methods and strategies for organic, macromolecular and supramolecular synthesis ellaborated recently in our laboratory will be discussed. PL13 Co-opting Moore’s Law: Vaccines, Medicines and Interfacially-Active Particles Made on a Wafer Professor Joseph DeSimone University of North Carolina at Chapel Hill In 1965, Gordon Moore, co-founder of Intel, described the trend that the number of components in integrated circuits had doubled every year since 1958. This trend has continued to today, enabled by advances in photolithography which has taken the minimum feature size of transistors down from about 10 microns in 1970 to 0.045 microns (45 nm) today. In biological terms, this corresponds to going from the size of a red blood cell to the size of a single virus particle! As such, this top-down nano-fabrication technology from the semiconductor industry is, for the first time, in the size range to be relevant for the design of medicines, vaccines and interfacially active Janus particles. This lecture will describe the design, synthesis and efficacy of organic nano- and micro-particles using a top-down nanofabrication technique we developed called PRINT (Particle Replication in Non-wetting Templates). PRINT is a continuous, roll-to-roll, high resolution molding technique that allows the fabrication of precisely defined micro- and nano-particles in a continuous manner with control over chemical composition, size, shape, deformability and surface chemistry. Examples to be described will include the design of PRINT particles useful as vaccines (influenza, H1N1, pneumo), targeted chemotherapy agents, anti-bacterials, inhalation therapeutics and even as an entirely new class of particle-based surfactants. 29 PL14 Hybrid Inclusion Complex (HIC) and its Key Role in Constructing New Polymeric Materials PL15 2012 Macro Group UK Medal for Outstanding Achievement Professor Ming Jiang and Guosong Chen Fudan University Perspective of Precision Radical Polymerization This presentation summarizes recent advances in new soft materials of polymers in which Hybrid inclusion complex (HIC) plays a key role. HIC is composed of a nano-sized inorganic core (quantum dots, silica particles, Au particles and graphene sheets etc.) and surface-attached organic species (surfactants, monomers, homopolymers and block copolymers etc.), where the core and surrounding species are connected by inclusion complexation between the host molecules on the nanoparticles and the guest moiety at the chain end of the organic species. HIC formed micelle-like structure in solution and realized further reversible micelle-vesicle transitions when it¡¯s hydrophobicityhydrophilicity balance was changed under environmental stimuli. For the cases of nano-spherical core, such transition took place much slowly at a temperature higher than the LCST. In addition, the advantages of the inherent reversibility of the inclusion complexation were fully taken in constructing functional hybrid hydrogels which reversely response to environmental stimuli such as temperature, light irradiation and introducing competitive host or guest molecules. Professor Mitsuo Sawamoto Kyoto University Precision or living polymerizations are now ubiquitous, covering nearly all the chain-growth mechanisms, and radical polymerization is not an exception. This lecture will discuss the status quo of these precision processes, particularly focusing on the metal-mediated living radical polymerization that we have been developing over the last decade. Among the current highlights are included abundant active, and functionalitytolerant iron [Fe(II)] catalysts, precision polymerization in water, and the wide-spread use of polar functional monomers that would in turn lead novel polymeric materials. Another is a challenging subject of sequence regulation in artificial macromolecules where desired functionality is placed at welldefined position and order along the backbone to realize functional macromolecules that function as autonomous singlechain molecules. The prospects and the challenges in commercialization of precision polymerizations will also be discussed. 30 AWARD LECTURES A1 Functional Conjugated Microporous Polymers - Sorption, Catalysis and Separation droplets in water. Larger oil droplets are obtained at lower copolymer concentrations for the spheres and vesicles, as expected. However, the worm-like particles exhibit qualitatively different behaviour, with a mean droplet diameter of 50 µm being obtained regardless of the initial copolymer concentration. Professor Andrew Cooper, J.-X. Jiang, S. Ren, R. Dawson, D. J. Adams, A. Laybourn University of Liverpool Conjugated microporous polymers (CMPs) are unique materials because they combine porosity with extended conjugation and the potential to incorporate a wide range of functional groups. In this talk we will show how these materials can be exploited in the areas of sorption, catalysis, and separations, focusing particularly on applications that exploit the conjugated nature of the networks. A2 Low Dimension Carbons as Functional Fillers and Reinforcements in Polymer Composites Dr Ian Kinloch, L. Gong, A. Raju, C. Valles, I. Riaz, R. Jalil, K. Novoselov, N. Wilson, J. Rourke, R.J. Young University of Manchester Understanding and controlling the interface between a nanofiller and the surrounding polymer is essential in order to achieve the full potential of the composite. Model systems have been used to consider two important interfaces in carbon nanotube and graphene polymer composites; the polymernanocarbon interface and the internal interface between the layers of the carbon materials themselves. A unified theory will be developed, identifying the design rules and target properties of these composites. A3 Stabilisation of Pickering emulsions using sphere, worm and vesicle nanoparticles prepared by RAFT aqueous dispersion polymerisation Ms Kate Thompson, Robert Verber, Adam Blanazs and Steven P. Armes The University of Sheffield All-methacrylic diblock copolymer spheres, worms and vesicles are prepared via RAFT aqueous dispersion polymerisation. These particles are effective Pickering emulsifiers for n-dodecane 31 INVITED LECTURES I3 I1 Functionalized Polyester and Glycidol Polymers with Control in Branching: Synthesis of Monomers and Supramolecular Network Formation. Professor Eva Harth Vanderbilt University The current interest in functionalized polyester, as well as polycarbonate systems for biomedical applications have motivated the development of ring-opening polymerization polymerization techniques that are practical and compatible with a wide range of functionalities. Hereby, we will address the control of polymerization with a variety of metal-catalyzed polymerizations as well as easy end-group removal. Functionalized polyesters and polycarbonates are investigated in the formation of nanoparticles utilizing the intermolecular chaincollapse process. The influence of the degree of polymerization and cross-linking densities as control mechanisms to control nanoparticle sizes and their tailored release kinetics are demonstrated. Furthermore, we will report on the kinetic control of the branching in polyglycidol backbones and copolymers to achieve hydrophilic nanosponges with integrated crosslinking units that facilitate H- bonding properties to biological structures. We found that a kinetic control of the branching is possible and we will present the first linear functionalized polyglycidols via ring-opening polymerization. I2 Interactive and responsive polymer brushes prepared via surface-initiated polymerization Professor Harm-Anton Klok Ecole Polytechnique Fédérale de Lausanne (EPFL) This presentation will discuss the preparation and properties of interactive and responsive polymer brushes prepared via postpolymerization modification of reactive precursor films that are obtained via surface-initiated controlled radical polymerization. After discussing different post-modification strategies and the characterization of the location and distribution of functional groups in such ultrathin coatings, their use for the fabrication of bioactive surface coatings or as functional films for microarray or sensory applications will be discussed. Macromolecular synthesis by photochemical methods Professor Yusuf Yagci Istanbul Technical University Light induced reactions in particular polymerizations find applications in many fields such as surface coatings, printing inks, adhesives, microelectronics, printing plates and three dimensional imaging and microfabrication processes. In this presentation, the development of new photoinitiating systems for radical, cationic and step-growth polymerization will be described. Besides curing applications, these methods can also be used in polymer syntheses. For example, block and graft copolymers, hydrogels, and cryogels were sucessfully prepared by using appropriate photochemical reaction and/or polymerizations. Special emphasize will be devoted to the nanocomposite formation through simultaneous redox and polymerization processes. Unconventional light induced reactions such as photoinduced click reactions for surface grafting, preparation of block copolymers and telechelic polymers will also be covered. I4 New ways of installing single reactive groups along a polymer chain or at the chain end Professor Patrick Theato University of Hamburg, Institute for Technical and Macromolecular Chemistry Classical polymer chemistry teaches us that a single functional group does not contribute to the polymer properties, which is true in most cases. However, nature tells us a different story. The photoisomerization of a single retinal molecule inside the protein rhodopsin is the mechanism for the highly sensitive ocular system found in vertebrate photoreceptors. This has motivated us to develop synthetic methods to install single reactive groups along a polymer chain or at the chain end. Thus, by post-polymerization modification single functional units can precisely be introduced. I5 Polymer-Peptide Biohybrids Dr Paul Topham Aston University 32 A novel approach to the synthesis of polymers covalently bound to short oligo-peptide sequences, known as polymer-peptide biohybrids (or conjugates), will be demonstrated and discussed. These biohybrids have been shown to subsequently selfassemble into nanotubes (via beta-sheet formation), which entangle to form three-dimensional networks capable of imbibing large volumes of water (i.e. hydrogels). The potential of such materials as injectable scaffolds will be explored. I6 dinuclear catalysts, based around Zn, Co(II/III) and Fe(II/III) metals, for the copolymerization of epoxides/CO2. These complexes, coordinated by a macrocyclic ancillary ligand, show high turn-over-numbers and turn-over-frequencies for the copolymerization, under very low pressures of CO2 (1 bar). The catalyst structure-activity relationships, kinetics and mechanism will be discussed. Furthermore, the application of the process to prepare new copolymers, with other bio-derived monomers (e.g. lactide) will be presented I9 Hierarchical Self-Assembly of Poly(Aryl-Triazole)s Professor Bert Klumperman, Rueben Pfukwa, Alan E Rowan Intelligent polymeric nanocarriers for anticancer therapy Dr Giuseppe Mantovani, Francesca Mastrotto, Stefano Salmaso, Paolo Caliceti Stellenbosch University Substituted poly(aryl-triazole)s were prepared that exhibit selfassembly into helical conformations when exposed to certain solvent conditions. In one example, the chirality of the sidechains controls the screw sense of the helix. In the case of an achiral side-chain, the screw sense of the helix as well as the length of the stacks of helixes can be controlled by the use of a chiral template. It will be shown that hierarchical control is optimally achieved in a dynamic equilibrium system. I7 University of Nottingham A major goal in cancer research is to develop carriers that can deliver drugs effectively to their target and without side effects. This study aims at engineering ’intelligent’ drug carrier devices based on a novel class of pH-responsive polymethacrylates made by RAFT polymerisation, which are able to release their drug payload in a controlled and predictable way in response to transient changes in pH typical of a range of disease microenvironments. I10 Dipeptide-based Gelators Dr Dave Adams, Lin Chen, Jaclyn Raeburn, Kelly Houton, Kyle Morris, Louise Serpell Introducing Stimuli Responsiveness Into Polymeric Nanoparticles with Dynamic Covalent Bonds University of Liverpool Dr David Fulton Gels can be formed by the supramolecular polymerisation of functionalised dipeptides. The properties of the gels depend critically on both the identity of dipeptide, and also on the process by which the self-assembly is achieved. Here, we will show fine control over the properties of the gels and discuss how this can be used to prepare gels for specific applications. Newcastle University I8 Catalytic activation of renewable resources in polymer synthesis Dr Charlotte Williams, M.R. Kember, A. Buchard, F. Jutz Imperial College London This paper describes new catalysts which facilitate polymer synthesis using renewable resources as the raw materials, including carbon dioxide and biomass derived carbohydrates. It will describe the preparation and properties of a series of new This talk will highlight recent work at Newcastle in which we have incorporated dynamic covalent linkages into a range of stimuli-responsive polymeric nanoparticle architectures, including core cross-linked star polymers, nanogels, micelles and single chain polymer nanoparticles. I11 New Synthesis of Biodegradable Nanoparticles based on Dextran Professor Thomas Davis, Felicity J. Hughes, Hien Duong, James M. Hook, Cyrille Boyer Australian Centre for NanoMedicine and Centre for Advanced Macromolecular Design 33 Soft core-shell polymeric nanoparticles are an area of great research interest, due to their potential advantages in the sustained and targeted delivery of therapeutic payloads including. While these systems can offer significant improvements in the temporal and spatial control of drug delivery, they often consist of synthetic polymers which are nonbiodegradable. This limits the possible dosage due to damaging accumulation of polymers in the body. For this reason, increasing effort has been directed toward developing biodegradable polymeric nanoparticles.In this talk, we present the preparation of nanoparticles using acetalated dextran modified with short PEG block. I12 Core-Shell Carbohydrate-Based Block Copolymers Designed for Biological Delivery Professor Theresa Reineke I14 Telechelic macromonomers by enzyme-catalyzed polymerization for thin film applications Professor Eva Malmström Mats Johansson, Magnus Eriksson, Stacy Trey, Emma Östmark, Karl Hult, Mats Martinelle KTH Fiber and polymer technology Lipase (Novozyme-435) is known to catalyze both the ringopening polymerization of lactones as well as the step-wise polymerization of low molecular weight multifunctional building blocks. Telechelic polymers can be synthesized by the appropriate choice of monomers. However, the kinetics is often challenging; long reaction times are needed to obtain polymers of high molecular weight. The aim of the present work has been to synthesize telechelic oligomers by lipase catalysis, crosslink the oligomers (thermally or photochemically) into thin films and eventually to evaluate the properties of the thin films. University of Minnesota The Reineke Group has developed a library of carbohydratecontaining polymers that encapsulate pDNA and siRNA into polyplexes that facilitate efficient intracellular delivery without toxicity in vitro and in vivo. Our group has also recently developed a series of amphiphilic diblock terpolymers containing carbohydrates for the delivery of small molecule drugs by combining anionic and RAFT polymerization techniques that form micelles that are colloidally stable in physiological salt and serum conditions. To examine the intracellular mechanisms and kinetics of delivery for these vehicles, three dimensional confocal microscopy imaging techniques have been developed. I13 The Science behind Rev7 – The Removable Chewing Gum Dr Victoria Osborne Revolymer Ltd. Chewing gum pollution is an eyesore and costly to clean-up; with UK local councils alone spending £150 million per year to remove gum cuds from pavements. Rev7 gum solves this problem with a novel amphiphilic polymer - the first novel chewing gum base ingredient approved in the last 40 years. This talk will highlight the problem, the science behind Rev7 and the development of test protocols. The talk will cover the story from the idea stage through to commercial reality - a great tasting, groundbreaking gum. I15 From Ultradense Arrays of Nanodots to Nanolines: A Route to Addressable Media Professor Thomas Russell University of Massachusetts As the size scale of features continue to shrink in devices, the use of self-assembly, i.e. a “bottom up” approach, for device fabrication becomes increasingly important. Yet, simple selfassembly alone will not be sufficient to meet the increasing demands place on the registry of structures, particularly nanostructured materials. A simple, versatile approach to the directed self-assembly of block copolymers into a macroscopic array of unidirectionally aligned cylindrical microdomains on reconstructed faceted single crystal surfaces or on flexible, inexpensive polymeric replicas was discovered. High fidelity pattern transfer to a master mold is shown. The exceptional alignment arises from entropic penalties of chain packing in the facets coupled with the bending modulus of the cylindrical microdomains. The atomic crystalline ordering of the substrate is transferred, over multiple length scales, to the block copolymer microdomains, opening avenues to large-scale rollto-roll-type and nanoimprint processing of perfectly patterned surfaces and as templates and scaffolds for nanowire arrays. 34 I16 I18 Electrical energy storage: How polymers can replace cobalt and enable printable batteries Pericyclic Reactions for High Resolution (Bio)Surface Design Professor Ulrich S Schubert Martin D. Hager, Tobias Janoschka, Thomas Jähnert, Bernhard Haeupler, Christian Friebe, René Burges, Andreas Wild, Andreas Winter Professor Christopher Barner-Kowollik Thomas Paulöhrl, Guillaume Delaittre, Michael Kaupp, Thomas Tischer, Anja Goldmann, Nicolas Zydziak Freidrich-Schiller-University Jena Institute for Technical Chemistry and Polymer Chemistry, Karlsruhe Institute of Technology (KIT) Rechargeable batteries, being a crucial element of a multitude of electronic devices, are vital to our technology-oriented and mobile society. A particular (political) challenge in the development of new batteries is going to be the accessibility of modern battery materials, such as cadmium, lithium, and, in particular, cobalt as well as rare earth metals. By utilizing organic, polymeric materials, which are based on readily available resources such as oil, coal; on the long run ; sustainable plant products, that problem can be overcome. I17 Polymer-Supported Catalysis: Synergy Between Catalytic Mechanism and Polymer Design The lecture will describe how light and thermally triggered pericyclic reactions can be utilized for the spatially highly resolved design of biofunctional planar surfaces and three dimensional nano-scaffolds as well as for the rapid modification of micro- and nano-particles, fullerenes and carbon nanotubes for applications ranging from targeted cell attachment to intelligent chromatography phases. The specific chemistries to be addressed include fast, quantitative and mild ligations via photogenerated o-quinodimethanes (photo-enol chemistry), nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) reactions as well as photo-triggered oxime and thiolene chemistries and mild thermally triggered hetero [2+4] cycloadditions. I19 Professor Marcus Weck Yu, Liu, Michael G.C. Kahn, Jie Lv, and Nina Schuchman New York University The development of highly functional group tolerant controlled and living polymerization methods, including controlled radical polymerizations and transition metal catalyzed ring-opening metathesis polymerization, has allowed for tuning the density and structure of the catalyst sites along the polymer chain, thereby enabling the development of structure property relationships between a catalyst and its polymer support. This fine-tuning of the catalyst-support interface in combination with a detailed understanding of catalytic reaction mechanisms has allowed not only for reusable and recyclable polymer-supported catalysts but also facilitated the design and realization of supported catalysts that are significantly more active and selective than their non-supported counterparts. The presentation will describe the basic design principles that have been developed by us for such optimized polymer-catalyst interfaces using polymer-supported metal-salen complexes as examples. In particular, we will present poly(oxazoline)s and poly(cyclooctene)s as unique platforms in supported catalysis both for single and tandem catalysis. One-pot multistep reactions based on thiolactones: extending the realm of thiol-ene chemistry in polymer synthesis Professor Filip Du Prez Pieter Espeel, Fabienne Goethals, Milan Stamenovic, Stefan Reinicke Ghent University The in situ generation of thiols by ring opening of a thiolactone with amines, followed by a variety of thiol-click reactions in a one-pot fashion has been recognized as an accelerated and versatile protocol for the synthesis of numetrous polymeric architectures. A number of straightforward synthetic routes based on readily available thiolactone-containing structures have been developed to successfully assemble functionalized, linear, hyperbranched and cyclic polymers on one hand and a new class of multi-responsive hydrogels on the other hand. 35 I20 I22 Synthetic Polymers with Controlled Primary Structures: Design, Folding and Function Self-Assembly of Macromolecules into Nanostructures in Solution Dr Jean-François Lutz Professor A. Levent Demirel Institut Charles Sadron Koç University Sequence-controlled polymerizations play a key role in nature. Although formed from a rather modest library of monomers, sequence-defined macromolecules such as proteins or nucleic acids are largely responsible for the complexity and diversity of the biological world. By analogy, one may predict that synthetic sequence-defined polymers could play an important role in modern applied materials science. Paradoxically, very little effort has been spent within the last decades for developing sequencespecific polymerization methods. Herein, new approaches for controlling polymer sequences will be discussed. Moreover, the advantages of the formed sequence-controlled polymers will be highlighted. For instance, the preparation of complex macromolecular structures such as 1D macromolecular arrays or folded polymer origamis will be presented. Possible technological applications of these single-chain objects will be also discussed. We have investigated the self-assembly of poly(2-alkyl-2oxazoline)s in aqueous solutions. Above lower critical solution temperature (LCST), the polymer molecules self-assemble into nanofibers. The characterization of these self-assembled structures by microscopy, differential scanning calorimetry and X-ray diffraction indicated that the fibers were formed by a slow crystallization process. For poly(2-ethyl-2-oxazoline)s, the addition of sodium acetate (NaAc) into the solution significantly increased the rate of agglomerate formation, but this was not due to salting-out effect of the CH3COO- ions. I21 Interfacing Materials with Biology: Glycoprotein Mimics and Smart Materials Dr Matthew Gibson Department of Chemistry Interfacing materials with biological systems is crucial to probe underlying process, but to also develop new, functional, biosensors, drug delivery systems, anti-infective treatments etc. Here I will discuss recent progress in the field of glycoprotein mimics and 'smart' materials. Using modern synthetic methodolgies, including tandem post-polymerization modification alongside structural biology information we have developed systems to probe multivalent binding of glycopolymers to lectins, for real healthcare applications. Secondly, the application of 'smart' materials to trigger cellular interactions in response to biochemical stimuli is discussed. I23 Porous Polymers by Emulsion Templating Professor Neil Cameron Durham University There are numerous routes described in the literature for the production of highly porous and permeable polymer materials for use as, for example, catalyst supports, tissue engineering scaffolds and separation media. However, many of these methods result in poorly defined materials with void sizes that are difficult to control and limited connectivity. One method that has the ability to create well-defined porous polymers (foams) is the so-called emulsion templating process, whereby a high internal phase emulsion (HIPE) is used as a precursor to a porous material. The presentation will describe the preparation of HIPEs and the resulting porous polymers (polyHIPEs) together with methods by which the morphology, properties and surface chemistry can be varied. Subsequently, the application of these materials as supports for catalysts and as 3D matrices for in vitro cell culture will be discussed. I24 Functional Polymer Interfaces for Switching Cell Fate Professor Joachim Spatz Max Planck Institute for Intelligent Systems & University of Heidelberg Our approach to engineer cellular environments is based on selforganizing spatial positioning of single signaling molecules 36 attached to inorganic or polymeric supports, which offers the highest spatial resolution with respect to the position of single signaling molecules. This approach allows tuning cellular material with respect to its most relevant properties, i.e., viscoelasticity, peptide composition, nanotopography and spatial nanopatterning of signaling molecule. Such materials are defined as “nano-digital materials” since they enable the counting of individual signaling molecules, separated by a biologically inert background. Within these materials, the regulation of cellular responses is based on a biologically inert background which does not trigger any cell activation, which is then patterned with specific signaling molecules such as peptide ligands in well defined nanoscopic geometries. This approach is very powerful, since it enables the testing of cellular responses to individual, specific signaling molecules and their spatial ordering. Detailed consideration is also given to the fact that protein clusters such as those found at focal adhesion sites represent, to a large extent, hierarchically-organized cooperativity among various proteins. Moreover, “nano-digital supports” such as those described herein are clearly capable of involvement in such dynamic cellular processes as protein ordering at the cell’s periphery which in turn leads to programming cell responses. I25 In Situ Hierarchical Formation of Giant Amphiphile nanocarriers, nanocontainers, nanoreactors. Professor Kelly Velonia, Eleftheria Daskalaki, Evangelos Liamas, Themistoklis Zisis, Kostantinos Chatzimanolis, Benjamin Le Droumaguet Department of Materials Science and Technology, University of Crete Amphiphilic protein-polymer chimeras –the so-called Giant Amphiphiles- are designed to mimic the hierarchical selfassembly displayed in both biological and synthetic material systems over a wide range of lengths. During the last years we synthesized and characterized several such protein-polymer amphiphilic bioconjugates through conceptually different synthetic approaches varying from the direct coupling of endfunctionalized polymers to proteins, to the grafting of polymers from protein macroinitiators. The synthesis, assembly and function of Giant Amphiphiles and biodegradable Giant Amphiphiles and our endeavors toward the construction of the first self-constructing/self-destructing Giant Amphiphile nanocarriers will be comparatively presented. It will be shown that Giant Amphiphiles assemble into well-defined, functional superstructures suitable for a variety of materials applications. The fact that Giant Amphiphiles are polymersomes, with biologically relevant structures, led us to study the possibility that they could also exhibit an increased -compared to synthetic polymersomes- affinity with living systems which could potentially bring them into the active arena of drug delivery or controlled release systems. Our investigations on the application potential of protein-polymer nanocontainers and nanocarriers will be discussed. I26 Stimulus-sensitive polymer bioconjugates for nanomedicine applications Professor Volga Bulmus Izmir Institute of Technology Polymer-biomolecule hybrids with stimulus-sensitive behavior potentially open routes to new strategies and systems for polymer-based nanomedicine applications. This talk will describe pH-responsive polymer-cholestrol conjugates and enzymesensitive polymer-RNA conjugates as potentially new components of intracellular therapeutic delivery systems. I27 Functionalization of Polypeptides via Thiol-X Photochemistry Dr Helmut Schlaad Max Planck Institute of Colloids and Interfaces Well-defined polypeptide homo- and copolymers with pendant carbon-carbon double/triple bonds are obtained by primary amine-initiated ring-opening polymerization of allylglycine and propargylglycine N-carboxyanhydride, respectively. The unsaturated side chains can be functionalized with thiols through irradiation with UVA-light in organic or aqueous solution, depending on the solubility of reactants. Reaction pathways and mechanisms of radical thiol-X photoaddition reactions will be discussed. I28 Varying polymer structures for delivering drugs and recognising cell signals Professor Cameron Alexander, Francisco Fernamdex Trillo, Johannes Magnusson, Sebastian Spain, Aram Saeed, Xuan Xue, Gokcen Yasayan and Martin Redhead University of Nottingham The flexibility inherent to modern polymer synthesis routes allows materials with many different functionalities and sequences to be prepared quickly and easily. The resultant 37 polymers can assemble into dynamic structures and architectures which mimic those of biological systems. In this talk, viral- and cell-mimic structures will be considered, which we have prepared to exhibit properties that enable them to deliver diagnostic or therapeutic cargoes, or even interfere with cell-cell signalling systems. I29 Development of a drug delivery system for platinum drugs Professor Martina Stenzel, Wei Scarano, Vien Huynh, Hien T. T. Duong, Khairil Juhanni Abd Karim, Sandra Binauld, Paul de Souza University of New South Wales The delivery of platinum drugs is hampered by substantial side effects. We developed a micellar drug delivery system by conjugating the drug to the polymer backbone. The uptake of these drug carriers by various cancer cell was found to be dependent on the structure of the polymer. To further enhance drug uptake and to add features to the drug carrier that enable the targeted delivery to the cancer site, folates were conjugated to the nanoparticle using either a permanent linker or a reversible borate ester. I30 Smart Polymersomes: from Biomimicry to Smart Drug Delivery A versatile and efficient functionalization strategy for polymeric nanoparticles has been reported and successfully applied to PEGylated, biodegradable poly(alkyl cyanoacrylate) (PACA) nanocarriers. The relevance of this platform was demonstrated in both the fields of cancer and Alzheimer’s disease (AD). Prepared by copper-catalyzed azide-alkyne cycloaddition (CuAAC) and subsequent self-assembly in aqueous solution of amphiphilic copolymers, the resulting functionalized polymeric nanoparticles exhibited requisite characteristics for drug delivery purposes: (i) a biodegradable core made of poly(alkyl cyanoacrylate), (ii) a hydrophilic poly(ethylene glycol) (PEG) outer shell leading to colloidal stabilization, (iii) fluorescent properties provided by the covalent linkage of a rhodamine Bbased dye to the polymer backbone and (iv) surface functionalization with biologically active ligands that enabled specific targeting. The construction method is very versatile and was illustrated by the coupling of a small library of ligands (e.g., biotin, curcumine derivatives and monoclonal antibody), resulting in high affinity towards: (i) murine lung carcinoma (M109) and human breast cancer (MCF7) cell lines and (ii) the amyloid peptide 1-42 , believed to be the most representative and toxic species in AD, both under its monomeric and fibrillar forms. In the case of AD, the ligand-functionalized NPs exhibited higher affinity toward species comparatively to other kinds of colloidal systems and led to significant aggregation inhibition of toxicity rescue at low molar ratios. This new functional synthetic tool may open an avenue towards efficient cell targeting for a broad variety of diseases, which is still an active challenge in the field due to the lack of appropriate nanoparticulate systems incorporating all the required features. I32 Professor Sebastien Lecommandoux Université de Bordeaux Functional Polymersomes via Kinetic Control Polymer vesicles (polymersomes) are one of the most promising systems for drug delivery applications. In addition to mimic structural biomolecules, the use of peptide and saccharide building blocks in the copolymer structure allows both controlling the self-assembled structure and the resultant biofunctionality. Our recent advances in using “biomimicry approaches” to design complex and compartmentalized materials will be proposed. Professor Jan van Hest, Daniela Wilson, Silvie Meeuwissen, René Brinkhuis, Ruud Peters, Iria Louzao I31 Dual Active Targeting Using a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease Dr Julien Nicolas, Benjamin Le Droumaguet, Davide Brambilla, Andrey Maksimenko, Elisa Salvati, Orfeu Flores, Massimo Masserini, Karine Andrieux, Patrick Couvreur Radboud University Nijmegen Three approaches are discussed in which the unique properties of polymersomes are utilised for the construction of biofunctional nanodevices. In the first part a polymersome system is presented which has been optimized for drug delivery across the blood-brain barrier. In the second part polymersomes are used which are porous for small substrate molecules, but not for enzymes. These nanoreactors are modified to act as artificial organelles. Finally, kinetic control is used to create polymeric stomatocytes, which can be modified into autonomously moving objects. Univ. Paris-Sud 38 I33 RAFT Aqueous Dispersion Polymerisation Professor Steven Armes and Adam Blanazs University of Sheffield Methacrylic AB diblock copolymers are prepared using reversible addition-fragmentation chain transfer (RAFT) chemistry via aqueous dispersion polymerisation. The A block is poly(glycerol monomethacrylate) [PGMA], while the B block is poly(2hydroxypropyl methacrylate) [PHPMA]. The PHPMA chains become hydrophobic as they grow from the PGMA macro-CTA, which drives in situ self-assembly. This versatile approach allows the synthesis of sterically-stabilised spheres, worms or vesicles with good size control at 10-25 % solids. The worms form biocompatible sterilisable gels. I34 Engineered Polymer Films and Particles Designed to Interface with Biology Professor Frank Caruso The University of Melbourne Stimuli-responsive polymers play a central role in the development of particle-based carriers for biomedical applications and biochemical reactions. This presentation will focus on polymer films and capsules assembled through the deposition of engineered polymers with tailored functionalities. New strategies to generate responsive particles through a single polymer adsorption step will also be presented. Utilization of these nanostructured particles for the encapsulation, protection and release of oligonucleotides and peptides to stimulate immune responses will be highlighted. I35 Microgels at the oil-water interfaces Dr To Ngai The Chinese University of Hong Kong Microgels are soft particles that consist of chemically crosslinked three-dimensional polymer networks. Touted as smart materials, they have attracted much research attention in the study of physics and chemistry of soft matter as well as in applied fields. Although the behavior of microgel particles in bulk dispersions has been extensively studied, there have been few reports aimed at improving understanding of their interactions and monolayer structure when adsorbed at liquid interfaces. Due partly to their ability to stabilize droplets in emulsions, leading to so-called Pickering emulsions, there has been a substantial increase in interest in this field during the past few years. Previous studies have shown some discrepancies on the emulsion stabilization/destabilization mechanisms involving microgels. To clarify the correlation between the stabilization of emulsions with the structure of microgels at the oil-water interface, we use a pendant drop tensiometer, to monitor the adsorption kinetics and evaluate the adsorption behavior of microgels at the oil-water interface. A better understanding of this mechanism is fundamental to designing stimuli-sensitive emulsions with desired properties. I36 Synthetic polypeptides as functional (bio)materials Dr Andreas Heise Dublin City University (DCU) Synthetic polypeptides can readily be obtained by ring-opening polymerisation of N-carboxyanhydrides (NCA). In this paper we will present results on our investigation of the temperature and pressure dependence of controlled NCA polymerisation. Moreover, the synthesis of advanced polypeptide architectures like block and star copolymers and their glycosylation by clickchemistry will be presented. Glycosylated polypeptide were further investigated for their self-assembly and interaction with biomolecules. I37 Multicompartment/Multicomponent Micelles with Block Copolymer Blending through Kinetic Control of Solution Assembly Professor Darrin Pochan University of Delaware The combination of charged block copolymers with the kinetic control of solvent processing offers great flexibility for the creation of new assembled morphologies in solution. When charged, acidic blocks are present, assembled structures are tunable in a well-defined way via co-assembly of organic bases with adjustable chain structure and control of the solution assembly pathway. A rich variety of polymeric nanostructures have been made such as toroids, disks, and helical cylinders along with nanoparticles with blends of block copolymers with unlike hydrophobic blocks. 39 I38 Designing Polymers with Strong Similarity to Biology Professor Gregory Tew University of Massachusetts, Amherst Department of Polymer Science and Engineering We are interested in elucidating the rules required to create biomimetics with structure and function rivaling proteins. While scientists have been interesting in polymers for almost 100 years, compared to their biology cousins including proteins and DNA, these molecules remain relatively unsophisticated. Our laboratory has focused on creating novel polymeric molecules with increased functionality in order to enable new properties and applications. In this lecture we will discuss our efforts to design and synthesize macromolecules that are membraneactive including host defense, or antimicrobial, peptide mimics. These novel mimics have potent antimicrobial activity. We will also discuss more recent work on protein transduction domain, or cell penetrating peptide, mimics. These novel mimics allow delivery to immune cells which has previously been impossible. In addition, they enable fundamental studies between macromolecules and the plasma membrane. I39 Polymers That Stabilize Proteins and Protein Conjugates to Environmental Stressors Professor Heather Maynard I40 Cucurbiturils at the Interface between Supramolecular Chemistry and Materials Science Dr Oren Scherman University of Cambridge Our research interests include the development of controlled polymer architectures, hybrid nanoparticle assemblies, and the integration of dynamic supramolecular systems at surfaces. Using cucurbit[n]urils (CB[n]s) we adopt a simple bottom-up approach to achieve sophisticated designs which are directed at the preparation of novel microcapsules, photonic devices, highdensity patterned media, and chemical and biological sensors. Our CB[n] based host-guest systems exhibit dynamic self assembly and are capable of responding to stimuli (photochemical, chemical, and thermal) which allow for external control and function to be built into the materials. Modification of solution viscosity and the formation of ultra-high water content hydrogels using multivalent polymers have been accomplished through dynamic crosslinking in water using CB[n]s to produce colorful hydrogels and hierarchical architectures. Furthermore, polymer-inorganic composite materials can be readily prepared based on the CB[8] coupling of multivalent gold nanoparticles to copolymers. When these systems are attached onto gold surfaces intricate control is achieved over the site-selective immobilization of colloids and peptides. This has great scope for the development of optical materials, chemical sensors and biological separations. I41 University of California at Los Angeles Protein-polymer conjugates are a class of materials widely used as drugs. Covalent attachment of polymer chains to proteins increases therapeutic potential. We have utilized controlled radical polymerizations to prepare polymers for site-specific conjugation to proteins, as well as to polymerize from proteins forming conjugates in situ. Both approaches result in conjugates where the protein viability is retained. In this talk, synthetic strategies, as well as application of the resulting conjugates in medicine will be discussed. Specifically, polymers that are based on natural sugars and stabilize proteins to environmental stressors such as heat, long term storage, acid, and desiccation will be presented. Plant oils: The perfect renewable resource for polymer science? Professor Michael Meier Karlsruhe Institute of Technology (KIT) In ages of depleting fossil reserves and an increasing emission of greenhouse gases it is obvious that the utilization of renewable feedstocks is one necessary step towards sustainability. Especially plant oils bear a large potential for the substitution of currently used petrochemicals, since a variety of value added chemical intermediates can be derived from these resources taking full advantage of nature’s synthetic potential. Here, new approaches for the synthesis of monomers as well as polymers from plant oils as renewable resources will be discussed. 40 I42 Designer Nanoscale Materials: Interfacial Manipulations in Block Copolymer Systems Professor Thomas Epps, Wei-Fan Kuan, Raghunath Roy, Maeva Tureau University of Delaware As future technological progress necessitates the design and control of nanoscale devices, new methods for the facile creation of smaller features must be discovered. Block copolymers provide the opportunity to design materials with attractive chemical and mechanical properties based on their ability to self-assemble into periodic nanoscale structures. To employ block copolymers in many applications, it is essential to understand how interfacial energetics influences the formation and processability of nanostructured materials. Two areas of recent research in our group involve: (1) manipulating the interfacial regions between copolymer blocks to control ordering transitions and self-assembly in network-forming tapered block copolymers, and (2) manipulating block copolymer thin film interfacial interactions using gradient methods to probe free and substrate surface interactions towards the creation of designer neutral (non-preferential) surfaces. I43 Miniemulsion Polymerization Using Graphene Oxide as Sole Surfactant Professor Per Zetterlund Professor Neil McKeown, Mariolino Carta, Matthew Croad, Richard Malpass-Evans, Yulia Rogan, Michael Lee Cardiff University Tröger's base (TB) was first reported by Julius Tröger in 1887 from the reaction between p-toluidene and formaldehyde. Its V-shaped, bicyclic structure and basic tertiary amine sites have made it a much studied building unit in supramolecular chemistry. We have found that by adapting the highly efficient synthesis of TB that polymers of high molecular mass can be prepared from appropriate aromatic diamine monomers. These polymer form robust solvent-cast films that display microporosity and remarkable behaviour for membrane gas separations. I45 Poly(2-oxazoline)s and beyond Professor Richard Hoogenboom Ghent University Poly(2-oxazoline)s are a versatile class of synthetic poly(amide)s that can be prepared by living cationic ring-opening polymerization (CROP). Within this contribution recent progress in the development of functional poly(2-oxazoline)s and their properties, including thermoresponsive behavior and biomedical applications, will be addressed. Further extension of potential of this class of polymers by polymerization of other cyclic imino ether monomers as well as by partial hydrolysis of poly(2oxazoline)s will be discussed. I46 The University of New South Wales Single-layer graphene is the strongest material known to man, and this is accompanied by a range of other extraordinary physical properties such as high thermal- and electrical conductivity. In order to fulfil the potential of polymeric nanocomposites based on graphene, a high degree of dispersion of graphene as individual two-dimensional sheets in the polymer matrix is essential. To this end, miniemulsion polymerization has been conducted using graphene oxide (GO) nanosheets as sole surfactant, exploiting the amphiphilic properties of GO nanosheets. I44 New tricks with an old bicycle: Microporous polymers prepared by the formation of Tröger's base A polymer approach to nanocrystal-based electroactive layers with tailored architectures for advanced energy applications Dr Brett Helms, Evelyn L. Rosen, Raffaella Buonsanti, Teresa E. Pick, Natacha Krins, Lina Zhu and Delia J. Milliron The Molecular Foundry - Lawrence Berkeley National Laboratory Enhancing the performance transition metal oxide (TMO) electrodes used in next generation energy devices - from lithium batteries and super capacitors to electrochromic windows and dye-sensitized solar cells - can be achieved by employing mesoporous films. Faster transport of ions through the network, coupled with strong nanosize effects in the TMO, overcome performance limits encountered with dense TMO thin films. Self-assembly of TMO precursors assisted by amphiphilic structure-directing agents (such as block copolymer or polar surfactants), is one of the classical methods enabling the 41 formation of highly periodic mesoporous nanostructures. The substitution of TMO precursor with pre-synthesized colloidal TMO nanocrystals, on the other hand, would allow for superior control over the crystallinity and composition of the films by separating the crystallization step from the assembly and the structuring agent decomposition. We will describe how a careful manipulation of the chemical affinity between the nanocrystal surface and the templating agent is the key to obtaining longrange ordered hierarchical mesoporous films. Using our tailored block copolymer structure directing agents, we show that different pore sizes and wall thicknesses are obtained by simply changing the molecular weight and the volume fraction of the blocks. The approach is general TMO nanocrystals of various size, shape and composition commonly employed in energy devices (i.e. ITO and CeO2 psuedospherical nanocrystals, or TiO2 nanorods). Our results lead to new design rules for rational, directed assembly of colloidal nanocrystals into mesoporous thin films relevant to energy. I47 Formation of Nanostructured Materials Using Amphiphilic Hollow Particles as Novel Building Blocks Professor Pei Li, Cheng Hao Lee, Kin Man Ho efficiently promote the ROP of lactide in a highly controlled fashion. In this presentation, our efforts in this area, and in particular the dual approach combining a Lewis acidic metal fragment and an organic base, will be presented. The applications of tailored-made polyesters in new drug delivery systems will also be presented. I49 Using Molecular Engineering to build Nanostructured Materials Professor Sebastien Perrier Key Centre for Polymers & Colloids, University of Sydney The lecture will describe new synthetic paths to design macromolecules showing excellent control over their topology and functionality. These synthetic macromolecules are then exploited to directly form functional materials, or associated to biopolymers such as peptides to form natural / synthetic polymer conjugates. The exploitation of these well-defined macromolecules for the design of functional nanostructured materials via molecular self-assembly and self-organization will be discussed, with examples of applications in the material and biomedical fields. The Hong Kong Polytechnic University I50 The formation of nanostructured materials via molecular selfassembly has attracted much attention throughout the past decade, driven by a wide range of possible applications for such materials in science and technology. In these studies, poly(ethyleneimine)-graft-poly(methyl methacrylate) (PEI-gPMMA) hollow particles were first prepared through partial removal of the PMMA cores of the PEI/PMMA core-shell particles. This simple and inexpensive assembly process using amphiphilic hollow particles as the building block is dramatically different from the well-known self-assembly of block copolymers into different nanostructures under equilibrium conditions. I48 Tailor-made Biodegradable Polymers: New Preparation Routes and Applications in Drug Delivery Systems Dr Didier Bourissou, E. Piedra-Arroni, F. Bensaid, A. Amgoune University of Toulouse Biodegradable polymers, and especially PLA, are receiving considerable attention as resorbable biomaterials as well as commodity thermoplastics. Important efforts have been devoted to the development of new catalytic systems that Synthesis of glycopolymers and their interactions with lectins Dr Remzi Becer , D.M. Mitchell, R. Wallis, D.M. Haddleton University of Warwick Glyco code runs the main operations in any living organism and it is crucial to learn and communicate with biological entities using their language. Controlled polymerization techniques and click reactions allow the preparation of glycopolymers with desired macromolecular architectures that can be used to mimic glycoproteins. In this paper, we discuss the effect of polymer architecture and composition on binding to dendritic cell lectins (DC-SIGN) and inhibition of their binding to HIV gp120. I51 The Scope for RAFT Single Unit Monomer Insertion Dr Graeme Moad, Daniel Keddie, Shadi Houshyar, Ezio Rizzardo, John Tsanaktsidis CSIRO 42 The scope for synthesis of new macro-RAFT agents (Z C(=S)S (M) R) by sequential insertion of monomers (M) ‘one at a time’ into an initial RAFT agent (Z-C(=S)S-R) will be explored. Critical factors for success are a high transfer constant for the RAFT agent and a high rate of addition of the radical to monomer relative to further propagation. With these conditions satisfied, the rate of reaction is largely determined by the rate of ; adding to monomer. Initiator-derived by-products (Z-C(=S)S-(M)-I) become an issue when is different from the initiator-derived radical . I52 Importantly, moderate changes in the elastic shear moduli of these heparin-containing materials results in marked differences in the adhesion and proliferation of multiple cardiovascular cell types, as well as phenotypic differences in gene expression. The combination of these results suggests potentially simple strategies for producing injectable cardiovascular therapeutics. We have recently expanded our scaffolds to include elastomeric polysaccharide-binding polypeptides with excellent mechanical properties. Ultimately, our investigations will help elucidate how interactions of specific cells with these materials can be modulated on the basis of mechanical and chemical cues, for development of hydrogels with controlled properties useful for biomaterials applications. Supercritical Fluids: A Dispersion Polymerisation Route to Nanostructured Block Copolymer Microparticles I54 Professor Steve Howdle, James Jennings, Jeremy T. Kennon Dynamic-covalent branched polymer assemblies University of Nottingham Professor Brent Sumerlin, Abhijeet P. Bapat, Soma Mukherjee, Jacob G. Ray, Daniel A. Savin We exploit the unique properties of scCO2 to develop a RAFT controlled dispersion polymerisation route to nanostructured polymeric microparticles formed from block copolymers. The process is efficient, with good control, high yields and requires no additional solvents. The internal structure of the microparticles reveals nanoscale morphologies, including multilayered, curved cylindrical and spherical domains. Control can be exerted by changing the constituent blocks. We also show that selective CO2 sorption influences the block copolymer phase behavior. I53 Biopolymeric conjugates as injectable cardiovascular therapeutics Professor Kristi Kiick University of Delaware We have previously demonstrated that heparin-modified glycopolymers can be assembled into hydrogels via their interaction with heparin-binding peptides and proteins, and that the release of growth-factor crosslinks from these materials provides a novel mechanism for targeted delivery. The addition of covalent crosslinking strategies to these approaches has permitted the facile generation of poly(ethylene glycol)-based hydrogels that are crosslinked via the Michael-type addition of thiol-PEGs to maleimide-functionalized heparins. Gelation and degradation rates can be manipulated based on variations in hydrolysis and thiol-exchange reactions, as indicated via NMR and LC-MS experiments, and growth-factor delivery from these matrices can be controlled. Southern Methodist University Macromolecular stars containing reversible boronic ester linkages were prepared by an arm-first approach by reacting well-defined boronic acid-containing block copolymers with multifunctional 1,2/1,3-diols. Homopolymers of 3acrylamidophenylboronic acid (APBA) formed macroscopic dynamic-covalent networks when cross-linked with multifunctional diols. On the other hand, adding the diol crosslinkers to block copolymers of poly(N,N-dimethylacrylamide (PDMA))-b-poly(APBA) led to nanosized multiarm stars with boronic ester cores and PDMA coronas. The assembly of the stars under a variety of conditions was considered. The dynamiccovalent nature of the boronic ester cross-links allowed the stars to reconfigure their covalent structure in the presence of monofunctional diols that competed for bonding with the boronic acid component. Therefore, the stars could be induced to dissociate via competitive exchange reactions. The star formation–dissociation process was shown to be repeatable over multiple cycles. I55 Elemental Sulfur: A novel feedstock for polymers and nanomaterials Professor Jeffrey Pyun, Woo Jin Chung, Adam Simmonds, Jared Griebel, Eui Tae Kim, Kookheon Char, Yung-Eun Sung Richard Glass University of Arizona 43 We will discuss our recent efforts on the utilization of elemental sulfur as a novel feedstock for novel polymers and nanocomposites for energy storage and optoelectronic materials. A tremendous abundance of sulfur is generated from hydrodesulfurization processes from petroleum refining. However, there are only a limited number of applications, such as, for fertilizers and sulfuric acid, that directly utilize sulfur. Furthermore, there is a clear need to develop chemistry and processing methods to enable utilization of sulfur as an alternative feedstock for materials. Considerable interest in lithium-sulfur (Li-S) batteries has spurred recent efforts toward the preparation of advanced sulfur-based materials for improved cathodes. Additionally, flexible organic materials of high refractive index (n > 2.0) have generated interest for photonic applications as microlens arrays and infrared optical technologies (thermal imaging, IR-optoelectronics). However, the inherent problems of elemental sulfur (poor electrical conductivity and mechanical properties, limited synthetic chemistry) have stifled more extensive efforts to prepare complex materials with a high content of elemental sulfur. We will discuss our recent developments in the chemistry and processing of elemental sulfur to prepare complex nanomaterials and discuss possible material solutions for applications in energy and photonics. I56 From copolymers to functional materials Professor Robert B Grubbs Stony Brook University Copolymers have been extensively investigated as frameworks for functional materials. For example, the block copolymer architecture allows specific particle-coordinating functional groups to be localized at the nanometer scale. Advances in synthetic chemistry have facilitated the preparation of functional materials by broadly expanding the range of functional groups that can be easily incorporated in polymer blocks. We will discuss our efforts to prepare functional copolymer systems, including block copolymers for organization of nanoparticles and stimulus-responsive copolymer assemblies, through the use of controlled polymerization techniques. Progress in the synthesis and characterization of these and other systems will be discussed. I57 Using the Dynamic Bond to Access Macroscopically Stimuli-Responsive Materials Professor Stuart Rowan Case Western Reserve University The reversible nature of the non-covalent bond allows access macroscopically adaptive, stimuli-responsive materials. As such the designed utilization of supramolecular chemistry in the field of polymer science has seen a dramatic growth in the last decade or so. We have been interested in the potential of such systems to access new material platforms and have developed a range of new mechanically stable, supramolecular polymer films that change their properties in response to a given stimulus, such as temperature, light or specific chemicals. I58 Beyond the Thermal Limit: Twisting & Stretching Molecules Using Mechanical Force Professor Christopher Bielawski, Kelly W. Wiggins, Johnathan N. Brantley University of Texas at Austin Mechanochemistry, whereby chemical transformations are facilitated using mechanical force, often induces reactivity that is otherwise inaccessible. In this presentation, we will describe how exogenous forces may be used to surmount thermallyinaccessible isomerization barriers, facilitate retrocycloadditions, and activate coupling or polymerization catalysts. I59 Degradable, Amino Acid-based Poly(ester urea)s for Bone Defect Repair Professor Matthew Becker, Fei Lin, Laura A. Smith Callahan, Mary Beth Wade, Andrew Esterle, Kimberly Stakleff, Brad D. Weiner The University of Akron Segmental bone defects represent a significant problem in orthopedic surgery. Current clinical approaches include scaffolds fabricated from growth factor impregnated polymers and ceramic materials. While these materials have seen instances of success, each has inherent shortcomings. This presentation will outline our efforts to develop a bioactive amino acid-based poly(ester urea) orthopedic scaffold with peptide-based 44 crosslinkers, which will both mechanically enhance the construct and increase natural bone growth in critical-sized defects. I60 I63 Functional patterned surface coatings by dewetting of thin polymer films From synthesis of biobased polymers by reactive extrusion to high performance durable materials Dr Chiara Neto, A.M. Telford, S. C. Thickett, A. Harris, J. Gamble, J. Moses Professor Philippe Dubois, Valérie Lison, Jean-Marie Raquez The University of Sydney University of Mons - UMONS We investigate dewetting in bilayers of thin polymer films, a spontaneous instability which occurs due to unfavourable intermolecular interactions. By finely tuning the physical and chemical properties of the bilayers, we produce functional surface coatings, which can be employed in a variety of biomedical and environmental applications. In this talk I will present two examples of application of this strategy, the first to produce biocompatible micro-patterned coatings for the selective attachment and patterning of endothelial cells, and a the second to produce coatings that capture water from the atmosphere. The first micro-patterned surface has the potential to guide the density and functionality of adsorbed cells, with the aim to improve the biocompatibility of stent surface coatings, while the second surface has the ability to collect considerable amounts of water from the atmosphere, mimicking the example of the Stenocara beetle of the Namib desert. In this contribution, it will be shown how reactive extrusion (REx) technology can serve on the sustainability and future growth of high performance and durable bioplastic materials. Various types of polymerization/functionalization reactions have been studied in twin-screw co-rotating extruders. For instance, both chain- and step-growth polymerizations have been sequentially carried out by REx offering new biobased polymers like high performance semi-crystalline polyester-urethanes. I61 Polymer synthesis incorporating N-alky urea peptoid oligomers Dr Neil Ayres I64 University of Cincinnati N-alkyl urea peptoids are pseudo-peptide oligomers. Significantly, the N-alkyl group is incorporated into the oligomer using an alkyl halide in a simple, high yielding reaction, leading to many possible oligomer permutations. The synthesis of new polymers containing N-alkyl urea peptoid segments will be presented using two strategies. Specific examples of N-alkyl urea peptoid containing polymers containing carbohydrate residues and self-assembling N-alkyl urea peptoid oligomers will be presented. I62 Thiol-Michael Coupling in Advanced Polymer Synthesis Professor Andrew Lowe, Meina Liu, M. Alyse Harvison Centre for Advanced Macromolecular Design New biomaterials-based approaches for tissue regeneration and biosensing Professor Molly Stevens Imperial College London Bio-responsive nanomaterials are of growing importance. Functionalised nanoparticle (NP) aggregates are useful systems as triggered changes in their aggregation states can be monitored. Our recent approaches to real-time monitoring of enzyme action using modular peptide functionalized NPs will be presented. Controlling the topography and chemistry of artificial nanostructured scaffolds that mimic the tissues in the body offer possibilities for stimulating growth of new tissue. Recent developments and novel approaches to in vivo tissue regeneration will be discussed. Thiol-Michael Coupling in Advanced Polymer Synthesis 45 I65 From self-assembly to self-recognition with nanobiopolymers Professor Dennis Discher I67 Opportunities offered by photopolymerization in continuous tubular reactors for the production of waterborne dispersions Professor José M Asua, Vesna Daniloska, Radmila Tomovska Univ. Pennsylvania Amphiphilic block copolymers can be made to assemble into robust morphologies that carry a wide range of drugs and allow in vivo tests of various carrier properties. We will describe polymersome delivery of multiple chemotherapeutics and RNAi using degradable and/or reducible polyester-based diblock systems. Therapeutic efficacy and transformation in degradation also motivate a detailed examination of cylindrical 'filomicelles' in both bio-imaging and delivery. Flexible filaments indeed prove interesting: they circulate a surprisingly long time and open the dosage window for more effective tumor shrinkage than seems possible with spheres of the same composition. Motivated by the benefits of persistent circulation, we will also outline efforts to design, develop and apply a 'Marker of Self' peptide that extends circulation by making immune cells, specifically macrophages, perceive nanoparticles as self rather than foreign. I66 Rules that determine the final morphology of poly(methacrylic acid-co-PEO methacrylate)-bpolystyrene block copolymer nanoobjects formed in situ by polymerization-induced micellization in water or in water/ organic cosolvent media. Professor Bernadette Charleux, Wenjing Zhang, Xuewei Zhang, Olivier Boyron, Franck D’Agosto, Jutta Rieger University Claude Bernard Lyon 1 The polymerization of styrene or benzyl methacrylate in the presence of poly(methacrylic acid-co-PEO methyl ether methacrylate) macroRAFT agents possessing a trithiocarbonate reactive group was studied under various experimental conditions performed in heterogeneous systems. The effect of pH, of the solvent (either water or a mixture of water and a miscible organic cosolvent), of the molar mass of the macroRAFT agent, of its composition and of the target molar mass of the hydrophobic block on the final morphology of the formed selfassembled nanoobjects was examined. POLYMAT, University of the Basque Country Waterborne dispersed polymers are produced by free radical polymerization initiated with thermal and redox initiators. This limits the range of temperatures as the process lacks of reproducibility at low temperature. Photoinitiation overcomes this limitation as it provides a very fast production of radicals at a wide range of temperatures, and spatial and temporal control of the polymerization. This work explores the use of photopolymerization in tubular reactors for the synthesis of waterborne materials such as hybrid PU-acrylic hybrids, nanolatexes and linear polyacrylates I68 Conjugation of polymers to proteins by bis-alkylation Professor Steve Brocchini UCL School of Pharmacy and PolyTherics Protein PEGylation has been around for decades. Much effort is focused to find alternatives to PEGylation. As a general strategy, PEGylation is unrivalled by any approach to improve the efficacy of protein-based medicines. We have developed linking moieties capable of efficient, site-specific conjugation by bisalkylation. This talk will describe what we have learned about the reaction of polymers with proteins using linker moieties that undergo conjugation by bis-alklyation. I69 Functional hydrophilic and amphiphilic polymers tailored for encapsulation and delivery. Professor Todd Emrick, Katrina Kratz, Rachel Letteri, Samantha McRae University of Massachusetts This presentation will describe the synthesis of novel hydrophilic and amphiphilic monomers and polymers that can be utilized in various modes of encapsulation and delivery. Especially emphasized will be novel zwitterionic structures prepared by controlled free radical polymerization, and alternatively ringopening metathesis polymerization. These polymers, depending on their backbone and pendent group characteristics, and 46 relative surfactancy, are useful as polymer micelles, polymer vesicles, and/or polymer pro-drugs in therapeutic applications. have also been used to modify methacrylic macromonomers for use in polyurethane chemistry to generate triblock copolymers. I70 The vinylic functionality of dimers and larger macromonomers of methyl methacrylate (MMA) can be epoxidised using mchloroperoxybenzoic acid. Model studies of the epoxidised dimer of MMA (ME) showed that homopolymerisation of the epoxide results in back-biting of the epoxide, even under cationic ring opening polymerisation conditions. Polymerisation of THF in the presence of ME (using BF3.OEt2 as the initiator) gave surprising results. Solution Self-assembly and Responsiveness in Polypeptide-based Block and Star Copolymers Professor Daniel Savin, Jacob G. Ray, Sandeep S. Naik, Jack Ly The University of Southern Mississippi The self-assembly of amphiphilic block copolymers is dictated primarily by the balance between the hydrophobic core volume and the hydrophilic corona. In these studies, amphiphilic block copolymers containing poly(lysine) (PK) and poly(glutamic acid) (PE) blocks were synthesized and their solution properties studied using dynamic light scattering, circular dichroism spectroscopy and transmission electron microscopy. This talk will present some recent developments in the characterization of peptide-based triblock and star rod-coil block copolymers in solution. First, the effect of morphological changes due to secondary structure transitions will be discussed in the context of interfacial curvature changes with pH and temperature. The second part of this talk will discuss the effect of using ‘click’ chemistry in the synthesis of rod-coil block copolymers in terms of creating interfacial frustration to control solution morphologies. In particular, the use of thiol-alkyne ‘click’ reactions yields materials that behave as polymeric phospholipids through the facile creation of 3-arm star polymers. The solution properties and responsiveness of these novel materials will be discussed. I71 Exploring the Chemistry of CCT-Derived Macromonomers Dr Hans Heuts Gemma Sanders I72 Molecular Heterogeneity in Self-Assembly: Is Monodispersity Necessary? Professor Mahesh Mahanthappa University of Wisconsin–Madison, Department of Chemistry The inherent chain length polydispersity of polymers derived from modern polymerization methods affects their ultimate materials properties and applications. We synthesized a series of poly(styrene-block-1,4-butadiene-block-styrene) triblock copolymers in which a polydisperse center block is flanked by monodisperse end blocks. Our systematic explorations of block polydispersity effects in melt-phase self-assembly show that monodispersity is not a necessary condition for microphase separation into well-defined morphologies. I73 Hyperbranched Polymers with Precisely Placed Functional Groups via ATRP and Conventional Radical Polymerization in the Presence of Efficient Chain Transfer Agents: Synthesis and Applications Rob Duchateau Professor Nicolay Tsarevsky Hongzhang Han, Khang D. Le, DeliaLaura Popescu Eindhoven University of Technology Southern Methodist University Since the discovery of catalytic chain transfer polymerisation (CCTP) in the 1970s, the reactive low molecular weight macromonomers characteristic of this technique have proven to be chemically versatile and easily industrially-scalable. Chain transfer constants for these polymerisations have been determined and detailed 2D NMR analysis was used to reveal that the end group of pSMA is maleic anhydride-based with a vinylic moiety, and for pASMA the end group is predominantly methyl styrene, also with a vinylic moiety. Further postpolymerisation functionalization of pSMA via Diels-Alder and thiol-ene reactions has also been explored. Thiol-ene reactions Hyperbranched polymers containing internal (bio)degradable disulfide or redox-responsive viologen groups as well as multiple alkyl bromide peripheral groups were synthesized by either ATRP of inimers or the copolymerization of monovinyl monomers (styrene, methyl vinyl ketone, or methacrylates) with functional dimethacrylate crosslinkers in the presence of carbon tetrabromide, which served as the source of terminal bromine atoms (via transfer to the propagating radicals). Another approach to hyperbranched polymers relies on the formation of inimers in situ via exchange reactions of the acetoxy groups in (diacetoxyiodo)benzene, PhI(OAc)2, or I- 47 acetoxybenziodoxolinone with acrylic, methacrylic, or 4vinylbenzoic acid in various solvents. The fast exchange of carboxylate ligands at hypervalent iodine centers was also used for the preparation of dynamic-crosslinked materials. I74 RAFT/MADIX-derived hydrophilic/CO2-philic diblock copolymers: synthesis and solubility in supercritical carbon dioxide Professor Mathias Destarac, Etienne Girard, Jean-Daniel Marty, Thierry Tassaing and Bruno Ameduri An ABA-type linear amphiphilic block copolymer was prepared by ATRP of butyl acrylate from a poly(ethylene oxide) macroinitiator and subjected to ring-closing metathesis to form an AB-type cyclic block copolymer. Micelles were formed from the linear and cyclic copolymers, and turbidity measurements were performed using a UV-vis spectrometer to examine the stability. I77 Patterning growth with photo-crosslinkable copolymer films Professor Ryan Hayward University Paul Sabatier, Toulouse III University of Massachusetts Amherst Novel amphiphilic block copolymers comprising a CO2-philic block are presented. RAFT/MADIX polymerization was selected for the production of well-defined block copolymers made of a poly(N,N-dimethylacrylamide) hydrophilic block and a poly(vinyl acetate) or a poly(vinylidene fluoride) (PVDF) CO2-philic block. In particular, the recently reported xanthate-mediated polymerization of VDF is described in detail. Copolymers with different chain lengths and hydrophilic/CO2-philic balance were prepared. Their solubility in sc-CO2 was determined. I75 Nanomaterials from photocleavable block copolymers Professor Jean-François Gohy Catholic University of Louvain This contribution highlights the synthesis of block copolymers containing photocleavable groups either as the junction between the blocks or as pendant groups in one of the blocks. The different synthetic strategies towards those two types of block copolymers are discussed and compared. The accordingly obtained block copolymers are further used for two distinct applications: photo-induced micellization and formation of nanoporous membranes with well-defined chemical functionalities on the pore walls. I76 Formation of a Micelle from an Amphiphilic Cyclic Block Copolymer and Determination of the Stability Dr Takuya Yamamoto, Satoshi Honda, Yasuyuki Tezuka Tokyo Institute of Technology A thin sheet subjected to spatially varying growth will buckle into a three-dimensional shape to lower its elastic energy. Such processes are common in biological morphogenesis, and would provide powerful tools for the design of actuating polymer micro-devices. While the relationship between stretching and the resulting surface curvature has long been understood, many questions remain regarding how a desired three-dimensional shape may be achieved by patterning the growth of a sheet with finite thickness. To address these questions, we have developed a system of patternable, temperature responsive sheets based on photo-crosslinkable poly(N-isopropyl acrylamide) copolymers. A simple grayscale lithographic approach provides access to sheets patterned with a small number of discrete swelling levels, yielding surprisingly rich behavior. Further, we have developed a halftoning approach that allows printing of effectively smooth, arbitrary two-dimensional patterns with only two photo-masks. I78 Polymeric vesicles mimicking glycocalyx (PVGs) for studying carbohydrate-protein interactions in situ by dynamic light scattering Dr Guosong Chen, Lu Su, Yu Zhao, Guosong Chen, Ming Jiang Department of Macromolecular Science, Fudan University Glycocalyx, a carbohydrate coat on cell surface, was proved extremely important in a variety of biological processes. In this work, polymeric vesicles mimicking glycocalyx (PVGs), a simplified model system, are achieved via our NCCM (noncovalently connected micelles) strategy. PVG is composed of hydrophilic glycopolymer and hydrophobic PNIPAM with the outer and inner surface layers of sugars, where the two homopolymers are connected by the dynamic covalent bonds between phenylboronic acid and sugars. The glycopolymers are 48 prepared by RAFT polymerization from novel -D-pyranosyl acrylamide as the monomer. This distinctive anomeric linkage of carbohydrates renders the PVGs the specificities in their interactions with different proteins. Then dynamic light scattering (DLS) has been employed for the first time to monitor the binding process between the sugars on PVGs and the carbohydrate-specific proteins in situ, showing remarkable advantages of DLS as a versatile, label-free and solution-based method. I79 Well-defined amine-reactive polymers: synthesis and reactivity Dr Sagrario Pascual, Hien The Ho, Martin E. Levere, Véronique Montembault, Laurent Fontaine Université du Maine - Institut des Molécules et Matériaux du Mans - UMR CNRS 6283 Strategies and recent developments used to prepare aminereactive polymers based on the azlactone functionality using controlled radical polymerisation (ATRP and RAFT) and thiolMichael addition “click” reaction are summarized. The ability of these well-defined polymers to react with amines is studied under mild conditions without the formation of by-products. Such reactivity makes them promising candidates for bioconjugation methodologies. I80 Design of Biodegradable Polymeric Nanoparticles for Delivery of Nitric Oxide. A New Hope for Multi-Drug Resistance in CancerTreatment Dr Cyrille Boyer, Hien Duong, Sharon Sagnella. Maria Kavallaris, Thomas P. Davis Centre for Advanced Macromolecular Design; The University of New South Wales Soft core-shell polymeric nanoparticles have been widely investigated as potential vectors for the sustained delivery of therapeutic payloads. In this talk, the synthesis of responsive nanoparticles will be shown to deliver consecutively nitric oxide (NO) and the therapeutic agent (doxorubicin) is used for the treatment of multidrug resistant in cancers (MDR). We have demonstrated that the treatment of MDR cells using NO allows the reduction of the production of proteins responsible to the resistance. we have designed biocompatible nanoparticles able to store NO and doxorubicin, and to release specially. Finally, these nanoparticles were tested to treat multidrug resistant in neuroblastoma cells. In-vitro data show promising synergetic effects when NO is combined with an anti-cancer drug. I81 Cascade Strategies for Polymerizing Renewable Diene Monomers Professor Robert Mathers Penn State University Ruthenium-catalyzed cyclization of alkenes in polyunsaturated plant oils (soybean oil, corn oil, and canola oil) provides renewable-dienes. The synthesis of 1,4-cyclohexadiene (1,4CHD) proceeds under nitrogen without the need for organic solvents or plant oil purification. After treating soybean oil with a ruthenium metathesis catalyst, the resulting 1,4-CHD was isomerized with a ruthenium hydride (RuH) catalyst. The isomerization in neat 1,4-CHD to 1,3-CHD was conducted with [1,4-CHD]/[RuH] ratios as high as 5000. Subsequently, polymerization of renewable 1,3-CHD with a nickel(II) catalyst was examined as a two-step sequence and as a one-step cascade reaction. I82 Orthogonally Functionalizable Polymeric Materials Professor Amitav Sanyal Bogazici University Recent years have witnessed an increased interest in the utilization of 'click' reaction based strategies towards efficient multi-functionalization of polymeric materials. Examples highlighting the design and synthesis of polymeric materials that allow efficient 'orthogonal' functionalization will be presented. I83 The development of fully injectable hydrogels for the treatment of degenerative disc disease Dr Chris Sammon, Christine Le Maitre, Victoria Boyes, Becky Barthrop Sheffield Hallam University This paper highlights the development and some of the properties of a recently patented polymer clay hydrogel precursor, which can be held in liquid form indefinitely above 40oC and allows the facile incorporation of mesenchymal stem cells (MSCs) via mixing. The MSC containing hydrogel liquid can be injected through a narrow gauge needle, readily plugs 49 fissures in a degraded (bovine) intervertebral disc (IVD), and then cools to form a gel (with rheological and mechanical properties similar to those of native nucleus pulposus) providing an excellent environment for the proliferation of MSCs. The pesentation will describe the synthetic approach to manufacturing these novel materials, outline our long term goals and show some of our exciting cell viability studies. I84 particularly bioactivation, is the dominant factor for these processes. Our study indicates a dominant role of morphology over surface activation concerning surface antigen expression, gene expression and cytokine release. I86 Responsive polymer-stabilised emulsion droplets: New properties and performance Self-Assembly of Amyloid Peptide/Polymer Conjugates Ms Rachel Harbron Professor Ian Hamley and V.Castelletto Imperial College London University of Reading I will discuss our recent progress concerning the synthesis and application of novel, pH-responsive and architecturally-defined branched copolymers. A focus will be on the use of these new polymers as efficient responsive emulsifiers which can impart new properties to the resulting emulsion droplets. I will discuss how controlling droplet surface functionality via careful polymer design can be used to initiate droplet-interplay events and reversible assembly processes. I will touch on a few highly complex emulsion systems and describe how stable droplets can facilitate phase transitions and the generation of new liquidbased materials. The self-assembly of PEG-peptide conjugates comprising designed amyloid peptide sequences based on Abeta(16-20), KLVFF, from the amyloid beta peptide has been examined using microscopic, scattering and spectroscopic techniques. Aqueous solution self-assembly into fibrils is examined and liquid crystal polymorphism is probed at high concentration in water. Enzyme responsiveness of PEG-peptide nanospheres is demonstrated. Control of beta-strand registry, along with self-assembled polymorphism, is investigated as a function of PEG chain length. I85 I87 Specifically Interacting Biointerfaces 2D vs. 3D: Cell Adhesion and Immune Response Radical Coupling: Access to midchain functionalized chains Professor Jürgen Groll, Karl-Heinz Heffels, Matthias Bartneck, Meike Beer, Kathrin Hahn Professor Thomas Junkers Universiteit Hasselt University of Würzburg We have recently reported a novel technique that allows rapid and reproducible preparation of 3D fibrous scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. This lecture compares 2D vs. 3D specifically bioactivated and interacting surfaces regarding their preparation and the ability of differentiated human primary cells (human dermal fibroblasts) to adhere and proliferate. Moreover, the most important reaction of primary human innate immune cells, blood derived monocytes and macrophages derived thereof, towards these materials is presented and discussed. Immune cells are present in the blood and in resident tissues, and their reaction towards body foreign material such as implants or other biomaterials is decisive for material success or failure. Macrophages may for example be activated to trigger inflammation, or alternatively activated, which supports healing and vascularisation. Especially the trend for 3D scaffolds with increasingly complex composition raises the question whether morphology or surface chemistry, Radical coupling techniques based on the atom transfer radical coupling (ATRC) protocol have received considerable attention as a design tool in advanced macromolecular synthesis. While classical ATRC is limited in its applicability due to occurrence of disproportionation, a wider scope is reached by employing radical spin traps as mediators of the reaction. Not only is radical combination enforced in that manner, also distinct functionalities are introduced at precisely predetermined location, allowing for synthesis of triblock, star or H-shaped polymers or even dendrimers. 50 CONTRIBUTED LECTURES C3 C1 Self-healing hydrogels for bio-applications Leading polymer development for the lubricants industry Dr Lei Tao, Yaling Zhang, Shuxi Li, Yen Wei Dr Tim Smith, David Price, Lindsey Bambra, Barrie Masters Tsinghua University Lubrizol Ltd A dynamic hydrogels is developed using chitosan and dibenzaldehyde PEG as main components. After mixing the telechelic PEG and chitosan solutions, hydrogels (solid 4 ~ 8 % by mass) are formed immediately (20 °C, gelation < 60 s) through Schiff base linkages. Due to the dynamic equilibrium between Schiff bases and reactants, the hydrogels are self-healable and sensitive to many bio-stimuli, such as pH, amino acids and vitamin B6 derivatives. The small molecular and protein incubated in the hydrogel have been successfully released. As futher study, the DNA incubated in the hydrogel could successfully express protein, and the cells grew well on the 2D hydrogel surface, indicating the hydrogel a potential biomaterials for pharmaceutical applications. The Lubrizol Corporation is a world leader in the commercial production of well-defined polymeric additives for the lubricants and personal care industries. This communication will discuss the reasons behind our pursuit of star-shaped polymers and detail our work with academia with particular focus on selfhealing polymers, cross-linking, and alternative controlled radical polymerisation techniques. C2 ATRPases: Enzymes that catalyze atom transfer radical polymerization Dr Nico Bruns, Tilana B. Silva, Marzena K. Kocik, Severin J. Sigg, Kasper Renggli, Farzad Seidi, Himanshu Charan, and Gergerly Kali University of Basel, Department of Chemistry Atom transfer radical polymerization (ATRP) is a powerful synthetic tool that is commonly used in polymer chemistry. This controlled radical polymerization leads to the synthesis of welldefined, end-functionalized polymers with complex molecular architectures. We discovered that heme proteins such as hemoglobin (Hb) and horseradish peroxidase (HRP) catalyze the polymerization of vinyl monomers in the presence of ATRPinitiators and the reducing agent ascorbic acid under conditions typical of activators regenerated by electron transfer (ARGET) ATRP. We call this novel biocatalytic activity ATRPase activity. It yields bromine-terminated polymer chains with polydispersities as low as 1.2. The reaction kinetics were of first order, and for some monomers such as poly(ethylene glycol) methyl ether acrylate (PEGA), the polymers’ molecular weights increased with conversion. These findings show that ATRPase activity is a controlled polymerization that involves reversible bromine-atom transfer between the growing polymer chain and the protein. ATRPases could become `green` alternatives to the transition metal complexes that are currently used as catalysts for ATRP, because proteins are non-toxic, derived from renewable resources, and (e.g. in the case of Hb) cheap and abundantly available. C4 Copper-mediated preparation of alkoxyamines and the SET/ARGET debate Dr Simon Harrisson, Patrick Couvreur, Julien Nicolas Université de Paris Sud XI We present a simple and general technique for the preparation of alkoxyamine initiators for nitroxide-mediated living radical polymerization (LRP) based on trapping radicals generated by reaction between an activated alkyl halide and copper metal. As this method replicates the key step of copper-0 mediated LRP, analysis of the reaction kinetics sheds light on the ongoing debate over the mechanism of this reaction (Single Electron Transfer vs Activators ReGenerated by Electron Transfer). C5 Single-Chain Nanoparticles via "Self-Click" Chemistry Professor Jose A. Pomposo University of the Basque Country Redox initiated RAFT polymerization allows the direct, room temperature synthesis of a variety of single-chain nanoparticle precursors (displaying narrow molecular weight dispersity, Mw / Mn = 1.16 - 1.37 up to Mw = 100 kDa) containing well-defined amounts of naked, unprotected acetylenic functional groups available for rapid and quantitative intrachain crosslinking via metal-catalyzed carbon-carbon coupling (i.e. C-C "click" 51 chemistry or "self-click" chemistry). To illustrate the useful "selfclickable" character of these new unprotected acetylenic precursors, single-chain nanoparticles have been prepared for the first time in a facile and highly-efficient manner by coppercatalyzed alkyne homocoupling (i.e. Glaser-Hay coupling) at room temperature under normal air atmosphere. C6 The Highly Controlled Synthesis of High Molecular Weight Star Shaped Polypeptides via NCA Ring Opening Polymerisation (NCA ROP) from a Dendritic Core. Dr Paul Thornton, Mark Byrne, Andreas Heise Durham University Polypeptides generated by N-carboxyanhydride ring-opening polymerisation (NCA ROP) have shown promise in a variety of biologically significant areas. Utilising a dendritic core to initiate the polymerisation enables to generation of branched architectures of molecular weights significantly greater than the corresponding linear polypeptide, in which instance the degree of polymerisation is limited. pH and enzyme-responsive star shaped polypeptides with potential applicability in controlled payload delivery were generated in a highly controlled manner. C7 Nano- and macrostructures derived from the supramolecular polymerization of pi-conjugated selfassembling peptides Professor J. D. Tovar, Brian D. Wall, Stephen R. Diegelmann, Allix M. Sanders Johns Hopkins University This talk will describe our efforts to synthesize and understand the photophysics of pi-conjugated self-assembling peptides that form one-dimensional electronically delocalized materials under completely aqueous conditions with the aim to bridge the biotic interface electronically. The peptide frameworks encourage the molecular self-association while also influencing solubility or biological interaction, and the pi-electron units can be varied to influence electronic properties. C8 Novel Reusable Reversible Polymer via Solid-state Topochemical Polymerization Professor Wenlong Cheng Monash University “Hard” microelectronics and “soft” biology play with different materials by different rules but they meet at the nanoscale. Thus, the nanoscale regime provides an ideal platform for us to interface electronic materials with biological system to design the powerful nanobionic materials that possess both “nano” and “bio” functions to address the pressing energy, environmental and health issues. In this talk, I will cover our recent discuss our success in manipulating plasmonic nanoparticles into superlattices with DNA and polymer ligands. C9 Poly(disulfide amine) for nucleic acid delivery Dr Nathalie Lavignac and A. M. Giordano Medway School of Pharmacy Gene therapy involves the transfer of genetic material into specific cells of patients. A new SS-PAA was synthesised by Michael polyaddition of cystamine bisacrylamide, 2methylpiperazine and hydroxyethylethylenediamine. The chemical structure was confirmed by 1H-NMR; (ppm): 1.33 (d, 3H, CH3 end chain), 1.43 (d, 3H, CH3 2MP), 2.71-2.77 (m, 16 H, H2C-C=O; CH2S), 3.32-3.86 (m, 31 H, CH2-N, O=CH2-CH2-N, CH2N2MP, CH2 DHE), 3.84-3.88 (CH2OH). The molecular weight was determined by GPC (Mw: 3,700 g/mol, PDI 2). Gel retardation assays demonstrated that the polymer was able to bind pDNA and could protect the plasmid from DNase degradation. Transfection experiments showed that the polymer could promote intracellular delivery of pGL3 plasmids in HEK293 cells with a transfection efficiency comparable to PEI but with lower cytotoxicity. C10 Synthesis of model branched polymers - the advantages of the macromonomer approach Dr Lian Hutchings Department of Chemistry, Durham University The past decade has seen an emerging interest in the design and synthesis of ever more complex, hierarchically branched polymers – often described as dendritically branched polymers. 52 In this presentation we will describe what DendriMacs and HyperMacs are and how we synthesise these branched polymers. We will also Tailored surface modification of biosubstrates • Demonstrate the advantages of the macromonomer approach for the synthesis of model branched polymers. Dr Anja Goldmann, Thomas Tischer, Leonie Barner, Michael Bruns, Hans G. Börner, Christopher Barner-Kowollik • Present rheology results coupled with TGIC data that demonstrate the credentials of DendriMacs as model polymers for structure property correlation studies Karlsruhe Institute of Technology (KIT) C13 • Demonstrate the versatility of the “macromonomer” approach by showing examples of branched polymers made from polystyrene, polybutadiene and PMMA C11 Caged Polyelectrolytes: Stimuli-Triggerable ChargeGeneration Polymers (CGPs) and Functional Materials Professor Shiyong Liu, Jinming Hu, Xiaorui Wang, Changhua Li University of Science & Technology of China We designed a new category of stimuli-responsive polymers termed as Charge-Generation Polymers (CGPs), which possess pendent carbamate-masked amine functionalities and can undergo stimuli-triggered transition from the initially neutral state to charged one in the presence of a specific analyte of interest such as thiols, hydrogen peroxide, enzyme or under photo-irradiation. Novel functional materials for chemo- and bio-sensing, tunable magnetic resonance (MR) imaging contrast effects, and drug delivery and controlled release nanocarriers have been constructed. The present lecture will describe how modular synthetic strategies in polymer chemistry can be employed to obtain tailored surface modified biosubstrates. The specific chemistries to be addressed include fast and mild ligation chemistries. It will be demonstrated how efficient ambient temperature and catalyst-free coupling chemistries are employed to alter the chemical and physical properties of biosubstrates. For instance, an access route to peptide modified cellulose was developed, where the peptide segments constitute specific functions. The route demonstrates that mild and catalyst-free conjugation strategies (i.e. HDA linkage) are ideally suited to ligate sensitive biomolecules to biological substrates such as cellulose. The synthetic efforts will be underpinned by the in-depth characterization of the obtained modified materials via surface sensitive characterization techniques i.e. X-ray photoelectron spectroscopy, scanning electron microscopy, elemental analysis, Fourier transform infrared (FT-IR) spectroscopy as well as Fourier transform infrared microscopy. Especially the visualization of individual modified cellulose fibers via high resolution FT-IR microscopy corroborates the homogeneous distribution of the polymer on the cellulose fibers. These cellulose systems can lead to significant advances in the field of reversible coatings of variable biosurfaces. C14 C12 Hierarchical Self-Assembly of Star-Shaped Organometallic Crystalline-Coil Block Copolymers in Solution Peptide-Based Nanomaterials from NCarboxyanhydrides Dr Sarah Hehir and Neil R. Cameron Professor Felix Schacher and Ulrike Freier Durham University Friedrich-Schiller-University Jena As the incidence of age-related eye disease increases, there is a requirement for materials to facilitate sustained drug delivery to the posterior segment of the eye. Polypeptides are ideal candidates due to their biocompatibility and biodegradability. Using ring opening polymerization of N-carboxyanhydrides, polypeptides possessing tunable properties can be prepared. This work outlines the synthesis of a series of block copolypeptides, peptide hybrid copolymers and photocleavable peptide-based materials and their assembly into various nanostructures. We describe the stepwise hierarchical self-assembly of starshaped organometallic crystalline-coil block copolymers with four arms, poly(ethylene oxide)-blockpoly(ferrocenyldimethylsilane) [PEO50-b-PFDMSx]4, into anisotropic superstructures of up to several µm length. The process takes place in mixtures of a common solvent for both blocks (THF) and a selective co-solvent (acetone, EtOH) and, in both cases, spherical intermediates could be identified via light scattering (DLS) and electron microscopic techniques (TEM, cryo-TEM). 53 C15 Fluorescence Switch On With Profluorescent Nitroxides in Epoxy Resins On Cure Professor Steven Bottle, John M. Colwell, Kathryn E. FairfullSmith, James Allen, Emmanuel Debele and James P. Blinco Queensland University of Technology The presence of profluorescent nitroxide (PFN) additives in polymer materials provides a powerful analytical technique able to deliver information on degradation levels and highlight damage arising from impact events. Incorporation of PFN’s into epoxy resins is an attractive goal, however high temperatures during cure can lead to fluorescence switch on, which reduces the available dynamic range of the response. Herein we report efforts to understand this process and suggest possible solutions. allow the synthesis of co-polymers of well-defined composition such as block co-polymers and structurally complex materials such as stars, brushes and combs. The traditional analytical technique for evaluating a new polymeric material is gel permeation chromatography (GPC), which allows assessment of the molecular weight distribution of a polymer. Advanced forms of the GPC experiment also allow investigation of structural properties in solution and important parameters such as molecular dimensions, making GPC an extremely powerful analytical tool. However, GPC is most suited to the analysis of board polymers of a homogeneous chemical composition – narrow polydispersity materials and those of a complex composition and structure can be difficult to analyze successfully. This presentation briefly discusses GPC analysis of polymers for composition and structure, and describes techniques for getting the best results from narrow polydispersity polymers synthesized by controlled radical polymerization techniques. C18 C16 Highly sequence controlled multiblock glycopolymers via Cu(0)-mediated radical polymerizations (SET-LRP) Controlled/”Living” Radical Polymerization of nonactivated monomers - industrial perspectives for poly(vinyl chloride) Mr Qiang Zhang Dr Jorge Coelho, Carlos M. R. Abreua, Patrícia V. Mendonçaa, Arménio C. Serraa, University of Coimbra Controlled/”living” radical polymerization methods available for vinyl chloride will be discussed from three main standpoints: degree of control over the polymerization, limitations and potential application at industrial scale. The strategy followed to scale-up the production of new block copolymers prepared based on poly(vinyl chloride) (PVC) by CLRP that have the same mechanical and thermal properties as the commercial PVC with external plasticizers will be discussed. C17 Gel Permeation Chromatography of Polymers under Extreme Conditions Dr Greg Saunders and Dr. Ben MacCreath Agilent Technologies Controlled radical polymerization techniques such as atom transfer radical polymerization and reversible addition fragmentation chain transfer have allowed the synthesis of narrow polydispersity materials without the stringent requirements of ionic polymerization. Also, these techniques University of Warwick We report a new approach for the facile synthesis of high-order multiblock glycopolymers. The approach entails sequential addition of different glycomonomers via an iterative single electron transfer - living radical polymerization technique, allowing the sequence control of the glycopolymer in microstructure scale. Different glycomonomers were synthesized through a Cu(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) of azide acrylate monomer with alkyl glycosides, which were first prepared from free sugar through a one pot Fischer type glycosylation reaction. We are aiming to synthesize sequenced controlled multiblock glycopolymers , i.e., sugar A-sugar B-sugar C- etc., through simple iterative addition of different glycomonomers with total or extremely high conversion. Mulitblock Poly (glucose-b-mannose-b-fucose) glycopolymers could be synthesized through iterative addition of glycomonomers after total conversion or equal time period. A new type of multiblock glycopolymers with both proteinconjugated and non-conjugated blocks, i.e., poly (DEGEEA-bsugar-b-DEGEEA-b-sugar-b-DEGEEA-b-sugar), was also synthesized through this approach and will be used for the understanding of glycode in carbohydrate-protein recognition. 54 C19 transition by NMR. This smart behaviour of POEGMA was exploited for self-assembly purposes. Investigation into the Mechanism of Microwave Induced Rate Enhancements in Chain Growth Polymerisation Dr Derek Irvine, Nguyen Nam, Jaouad El Harfi, Kamaruddin Mohd, Ed Greenhalgh,Sam W. Kingman, John P. Robinson University of Nottingham The proposed advantages offered by the use of microwave energy in polymerisations include rapid bulk heating, good temperature homogeneity and selective heating. This paper will report the results of our latest work targeted at defining the actual effects of applying microwave energy to chain growth polymerisations. Data will be presented that demonstrates the key benefits of applying microwaves to these systems. Furthermore, these results will be cross-referenced to the dielectric property predictions. C20 Gold nano-particles and multi-block copolymers from RAFT – a love story Professor Philipp Vana, B. Ebeling, C. Catli University of Goettingen - Institute of Physical Chemistry RAFT-polymers from trithiocarbonate-mediated polymerization of NiPAm strongly bind to uniform gold nano-particles without further end-group modification. The evolved nano-hybrids show pronounced self-assembling behavior resulting in colloidal crystal structures. Multi-block copolymers from RAFT using polytrithiocarbonates bind differently to gold, leading to changes in stability, in interparticle distances, and in self-assembly characteristics. The resulting materials show potentials for sensor applications and catalysis. C21 UCST-type behaviour of POEGMA in alcohols: Structure Dependence and Applications C22 Synthesis and Characterization of various copolymers from a carbohydrate lactone and their applications in medicine and in cellulose nanocomposites Dr Min Tang, Koonyang Lee, Matthew Purcell, Bismarck Alexander, Steve Howdle, Molly M. Stevens, Charlotte K. Williams* Imperial College London We are particularly interested in the preparation of functionalized lactones from renewable resources, such as carbohydrates, due to the sustainability of the raw materials and the ability to take advantage of naturally high degrees of chemical functionality, stereochemistry, hydrophilicity and degradability to metabolites. The carbohydrate used here is Dgluconolactone, which can derive from various biomass sources. The presentation will describe the synthesis and ring-opening polymerization of the carbohydrate derived lactone, obtained in excellent overall yield from D-gluconolactone in two steps. The polymer properties, including its spectroscopic characterization, thermal properties and hydrophilicity will be outlined. Copolymer syntheses and characterizations will be described, including experiments to determine the copolymer’s thermal, surface, degradation rates and biocompatibility. The copolymers are compared with polylactide; they show enhanced degradation rates and superior properties for SaOS cell proliferation and growth. The copolymer is also applied as a compatibiliser to enable the preparation of bacterial cellulose (BC) enforced polylactide nanocomposites. The copolymer’s syntheses, characterizations and super critical CO2 foaming are described. The copolymers are compared with polycaprolactone; they show enhanced foam-ability, indicated by greater porosity, more interconnected pores and larger pore size. The pore size could be controlled by altering the percentage of new lactone in the copolymer, which makes it potentially useful for a range of tissue engineering applications. Dr Peter Roth, Giles B. H. Chua, Thomas P. Davis, Andrew B. Lowe CAMD, University of New South Wales Poly[oligo(ethylene glycol) methylether methacrylate]s show insoluble-soluble (UCST-type) phase transitions in aliphatic alcohols. The dependence of the critical temperature on concentration, alcohol structure and polymer structure was investigated in detail. Diblock copolymers provided the possibility of monitoring molecular events during a phase C23 Novel Reusable Reversible Polymer via Solid-state Topochemical Polymerization Dr Kei Saito, Priscilla Johnston, Dylan Wheldale Monash University 55 Solid-state topochemical polymerization is one way to synthesize novel macromolecular architectures with stereoregular chain structures. Topochemical reactions are attractive, “green” synthetic pathways in material design since they occur in solvent-free conditions, and in response to external stimuli such as heat and light. However, only a limited number of monomers are shown to undergo topochemical polymerization. For the first time, we have used the reversible cycloaddition of a bioinspired bis-thymine monomer to topochemically synthesize a polymer. This polymer can be fully photo-depolymerized to the monomer, and then reversibly and repeatedly photo-polymerized and photo-depolymerized. This is the first demonstration of complete photo-depolymerization and subsequent monomer recycling using this mechanism. This new material could open the field to new classes of topochemical polymers that utilize alternative photo-reversible moieties. C24 The assembly and functions of DNA-dendron hybrid Ms Zhongqiang Yang, Liying Wang,Ping Chen, Yawei Sun, Dongsheng Liu Tsinghua University Combining available components with different structures and functions, for example, biomacromolecules and organic polymers, to get new hybrid molecules is definitely an efficient tool in designing new functional molecules. We have successfully built several DDH systems. A DDH molecular motor based on the i-motif structure was synthesized for the first time and was proven to be able to actively control the association/dissociation of the two attached dendritic macromolecules. Moreover, we also combined the DDH above with the streptavidin-biotin complex and fabricated a dendronDNA-protein hybrid molecular system. It is demonstrated that the size of this molecular system could be reversibly switched due to the pH responsiveness of the i-motif structure. In conclusion, DNA-dendron hybrid as a new supramolecular building block has showed many interesting properties. We have made some progress on this area and other related work is underway. We believe this kind of hybrid will be useful in constructing functional systems and open up a wide range of applications in drug delivery, supramolecular templates, biosensors and so on. C25 In-situ Studies of Spin Coating of Polymer Blends. Dr Jonathan Howse University of Sheffield Spin coating polymer blend thin films provides a method to produce multiphase functional layers of high uniformity covering large surface areas. Two novel in-situ imaging techniques which allow for the direct observation of the phase separation during spin coating will be presented. C26 Functionalized organocatalytic nanoreactors: hydrophobic pockets for acylation reactions in water Mrs Pepa Cotanda, Annhelen Lu, Joseph Patterson, Nikos Petzetakis, Rachel O'Reilly University of Warwick The effect of having 4-dimethylaminopyridine (DMAP) functionality covalently attached to the hydrophobic core of a polymeric micelle in water has been investigated in the context of acylation reactions employing non-water-soluble substrates. For this purpose a novel stimuli-responsive polymeric micelle has been synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization techniques. The reactivity of the tethered organocatalyst within the nanostructure was found to be high, improving in some cases the acylation rates up to 100 times compared to those for unsupported DMAP in organic solvents. Moreover, the catalytic nanorecators have been reused up to 6 times with high activity. C27 Green Composites from Waste Materials Professor Saad Uddin Choudhury, Sonali Bora Hazarika and Ajmol Hussain Barbhuiya Cotton College State University A noble green composites is prepared from betelnut and murta waste available in village of indian subcontinent . It has been characterized by various physical methods like SEM. AFM, etc. Outer part of the betel nut is thrown out without any use. Moreover murtha is not used commercially. The composites we prepared can be used as false ceiling , false partitions etc. C28 Surface-initiated polymerisation from cellulose nanocrystals Dr Wim Thielemans, Marianne Labet, Gaelle Morandi University of Nottingham 56 We have been working on the grafting of cellulose nanocrystals with polymer brushes by surface-initiated ATRP and ROP. We were able to control the polymer brush length and thus the characteristics of the nanoparticle surface. Furthermore, ROP made use of citric acid as a benign catalyst to replace more harmful metal-based catalysts. We also developed a photocleavable linker which showed that the polymer brush characteristics are consistent with those initiated by sacrificial initiator. C29 One-step preparation of uniform cane-ball shaped water-swellable microgels Dr Brian Saunders, Sineenat Thaiboonrod, Francesco Cellesi, Rein Ulijn University of Manchester We report the preparation of a new family of core-shell microgels that are water-swellable and have a morphology that is controllable using particle composition. Monodisperse coreshell poly(N-vinylformamide-co-glycidyl methacrylate) particles were prepared using non-aqueous dispersion polymerisation. The particles had a “cane-ball” like morphology with interconnected ridges which could be controlled. Hydrolysis was used to prepare poly(vinylamine). Remarkably, the shells could be detached from the hydrolysed particles by dispersion in water followed by drying. C30 Synthetic vaccines - mimicing microbial structure and function Dr Bruno De Geest, and Stefaan De Koker Ghent University Many of today’s most effective vaccines are based on parenteral delivery of attenuated variants of pathogens. Here explore electrostatic self-assembly of polypeptide and polysaccharide based polyelectrolytes to design engineered ‘microbial mimicking’ polymeric carriers consisting of a capsular shape, containing the antigen, and bearing immune-stimulatory motifs on their surface. Polymeric multilayer capsules were templated on calcium carbonate microparticles loaded with ovalbumin (OVA) as model antigen. These engineered carriers were then evaluated in mice models for viral infection (i.e. influenza) and cancer (i.e. melanoma) and demonstrated to confer protective immunity, which was not the case for unformulated soluble antigen. Importantly we also developed strategies to reduce the amount of batch steps, required to assemble polyelectrolyte complex particles, in order to allow production on an industrial relevant scale. C31 PVCL-based biocompatible nanogels for biomedical applications Dr Jose Ramos and Jacqueline Forcada University of the Basque Country UPV/EHU Poly(N-vinylcaprolactam) (PVCL) is one of the several nonionic water-soluble polymers that undergo heat-induced phase separation in water. Nanogel particles based on temperaturesensitive polymers undergo reversible volume-phase transitions between swollen and shrunken states in response to changes in temperature, swelling at low temperatures and collapsing at high ones2. This unique behavior makes nanogels attractive for therapeutic and biotechnological applications. Although poly(Nisopropylacrylamide) is the building block of a huge amount of nanogels reported in the literature, PVCL is especially interesting due to the fact that, as commented before, it is very stable against hydrolysis and biocompatible. C32 Batch RAFT emulsion polymerization mediated by poly(methacrylic acid) macroRAFT agents: one-pot synthesis of self-stabilized particles Dr Muriel Lansalot, Isabelle Chaduc, Franck D'Agosto and Bernadette Charleux CNRS - C2P2 The present paper describes the one-pot synthesis of selfstabilized particles composed of amphiphilic block copolymers based on poly(methacrylic acid) (PMAA). First, RAFT polymerization of MAA is performed in water. The resulting hydrophilic macroRAFTs are then chain-extended in situ with a hydrophobic monomer to form amphiphilic copolymer chains of controlled molar masses that self-assemble into stable nanoparticles. Various parameters such as the pH, the length and concentration of the PMAA segments or the nature of the hydrophobic block have been investigated. 57 C33 Optical and Mechanical Properties of Hollow Silica Nanoparticles Dr Markus Retsch, Markus Retsch, Marcus Schmelzeisen, Jie Yin, Jae-Hwang Lee, Hans-Jürgen Butt, Mary C. Boyce, Edwin L. Thomas University of Bayreuth Using monodisperse latex particles as sacrificial template, we fabricate well-defined hollow silica nanoparticles (HSNP) and investigate their optical and mechanical properties. The ultralow refractive index of such powders suppresses multiple light scattering and allows for a direct observation of Mie resonances. Compression of self-assembled HSNP films features a non-linear force-penetration profile and the underlying mechanics are elucidated by theory and modeling on a single particle level. C34 aqueous solution. The cores of micelles (or the walls of vesicles) are composed of hydrophobic PS and the hydriphilic AuNPs are in the shells of micelles (or vesicles).The hydrophilicity of the hybrid polymers plays a key role in the fabrication of the selfassembly structures. C36 One-Step Synthesis of Shape and Optically Anisotropic Polymer Particles Dr Jonathan Henry Wilson, Laura Ramon-Gimenez, Owain Parri, Mark Goulding, Roger Kemp, Louise Farrand Merck Chemicals Ltd One-Step Synthesis of Shape and Optically Anisotropic Polymer Particles C37 Monodisperse Liquid Crystal Elastomer Particles by Dispersion Polymerisation Synthesis of Polysaccharide-b-PEG Block Copolymers by Oxime Click and their use for the formation of interpolyelectrolyte nanogels Dr Verena Gortz, K L Holdsworth Dr Ramon Novoa-Carballal, Axel H.E. Müller University Of York University of Bayreuth D-95440 Bayreuth In lightly crosslinked polymer particles with internal liquidcrystalline order a spherical anisotropic confinement is combined with the properties of elastic polymer networks, allowing the properties of bulk liquid crystal elastomers to be realised on the microscale. We present the synthesis and properties of monodisperse LCE particles prepared using a dispersion polymerisation method. We realised monodisperse spherical and non-spherical particles exhibiting birefringence in polarising optical microscopy which, for spherical particles, is bipolar. Polysaccharides have extraordinary properties as structural materials for drug delivery micro and nanocarriers: they are renewable, inexpensive, biocompatible and biodegradable. C35 Self-assembly of Gold Nanoparticles at Liquid-Liquid Interface and Fabrication of Polymer-Gold nanoparticles Ordered Structures Professor Hanying Zhao, Jia Tian and Xiwen Zhang We show here that the oxime click reaction is a straightforward methodology for the synthesis of poly(ethylene glycol) (PEG)polysaccharide diblock copolymers. The method is applicable to unmodified polysaccharides with a reductive end as demonstrated for dextran, hyaluronic acid and chitosan. Notably the oxime click reaction is applied for the first time to the end modification of polysaccharides. As a proof of concept it is demonstrated that the crosslinking with cabodiimide leads to nanogels with high stability against ionic strength. We believe that the the formation of IPEC nanogels from a charged polysaccharide-b-PEG and a polypeptide (that may be extended to DNA if chitosan-b-PEG is selected) has an enormous potential in drug delivery. Nankai University Polystyrene (PS) with pendant hydrophilic gold nanoparticles (AuNPs) were synthesized by free radical copolymerization of styrene and AuNPs monomer at liquid-liquid interface. The hybrid polymers can self-assemble into micelles or vesicles in 58 C38 Selenium-containing Polymers: from Molecular Design to Controlled Self-assembly and Disassembly Dr Huaping Xu and Xi Zhang biological, structural and chemical properties. Matching this structural control in synthetic polymers is an important goal of macromolecular scientists. Here we report a novel strategy for the synthesis of multiblock copolymers, which comprise very short blocks (on average two monomers units) using Cu(0) mediated LFRP. This is achieved in high yield, with narrow polydispersity and controlled structural complexity. Tsinghua University Redox responsive polymers have attracted wide interest for their promising applications in controllable encapsulation and delivery in physiological environments, where the redox process is constantly and widely present. A series of selenium-containing polymers, including main chain and side chain block copolymers, dendrimers and hyperbranched polymers, have been designed and synthesized for controlled self-assembly and disassembly under various responsive stimuli, which may act as new biomaterials for controlled drug delivery and gene therapy. Among them, the diselenide-containing block copolymers formed aggregates are sensitive to even a low dose of radiation, such as 5 Gy, which is close to the radiation dosage received by patients during a single radiotherapy treatment, thus open an avenue for the combination of radiotherapy and chemotherapy. C39 Development of a Photo-Controlled Living Radical Polymerization Process C41 A Platform for Functional Conductive Polymers Dr Anders Egede Daugaard, Christian Hoffman, Johan Ulrik Lin, Thomas Steen Hanse, Niels B. Larse, Søren Hvilsted Technical University of Denmark Conductive polymers have been studied extensively during recent years. Through selection of reaction conditions it is possible control the depth of the reaction into the polymer film to the upper surface or the entire film. The electrodes have been applied in controlled localized click reactions through ”electroclick” reactions. This enables preparation of both highly functional electrodes as well as gradient surfaces. The system is very versatile in all dimensions and structures and allows for preparation of conductive polymers with very specific properties. Recent results on a grafting from method to modify the surface properties will be presented. C42 Dr Brett Fors and Craig J. Hawker University of California This presentation will detail the development of a living free radical polymerization process that is regulated by an external stimulus (visible light). This new polymerization method displays excellent control over polymer molecular weight and molecular weight distribution and can be efficiently activated/deactivated by visible light. Further, this method exhibits broad functional group compatibility and allows for the synthesis of highly controlled block copolymers. Lastly, insight into the mechanism and controlling factors of this process will be discussed. C40 Living Free Radical Polymerisation in the Presence of Cu(0): Towards Biological Precision Dr Michael Whittaker, Alexander H. Soeriyadi, Fredrik Nystrom, Cyrille Boyer, Per Zetterlund Centre for Advanced Macromolecular Design (CAMD) The specific distribution/placement of monomer units along a biomolecule chain (e.g. protein) confers their remarkable Thermosensitive and complexing poly(N-npropylacrylamide)-b-poly((dimethylphosphoryl)ethyl acrylamide) block copolymers for water treatment Dr Sophie Monge, Alain Graillot, Denis Bouyer, Catherine Faur, Jean-Jacques Robin Institut Charles Gerhardt UMR5253 CNRS - Equipe IAM Université Montpellier 2 The reported work describes the synthesis of original poly(N-npropylacrylamide)-b-poly((dimethylphosphoryl)ethyl acrylamide) block copolymers, prepared by reversible addition-transfer polymerization. Such original materials combined both thermosensitivity and complexing properties from propyl acrylamide and phosphonated moieties, respectively. Both characteristics were employed to achieve water treatment. In particular, removal of metal ions from aqueous effluents was achieved involving these new thermosensitive polymeric sorbent. C43 59 ARGET ATRP and Polydopamine Initiators for Versatile Polymer Brush Growth Here we describe the development of novel polymeric vaccine adjuvants. C46 Dr Steve Edmondson and Bocheng Zhu Department of Materials, Loughborough University Polymer brushes (polymer chains end-tethered to a surface) are a versatile route to modifying surface properties. The broad use of this technology is limited by the need for substrate-specific initiators and the stringent conditions often required for controlled polymerisation. We have developed an initiator based on polydopamine which allows polymer growth from a wide range of substrates. We have also explored the use of ARGET ATRP for rapid polymer film growth under less stringent conditions. C44 Polymers from renewable resources and robust, efficient and orthogonal chemistries Professor Eric Drockenmuller, Pascal Dimitrov-Raytchev, Céline Besset, Jean-Pierre Pascault, Julien Bernard Preparation of polyethylene (PE) bearing functional chain ends and their use for the design of original PE based materials. Dr Franck D'Agosto, Ian German, Jérôme Mazzolini, Edgar Espinosa, Christophe Boisson CNRS UMR 5265 C2P2 LCPP Team In the field of polyolefins, industrial polymerisation techniques (free radical polymerisation under high pressure/high temperature, polymerization using coordination chemistry) do not accommodate chain-end functionalisation. We have recently developed an efficient method to produce well–defined, linear, end-functional polylethylenes via catalytic polymerization followed by high yielding end-group transformations. This paper will present our most recent investigations in this field and their applications including in the field of supramolecular chemistry. Uuniversity of Lyon In the context of fossil fuels rising costs and rarification, materials issued from abundant and renewable agro-resources are highly attractive. In particular, the combination of 1,4:3,6dianhydrohexitols or levulinic acid with different robust, efficient and orthogonal coupling chemistries and polymerization methods afforded a broad library of bio-based polymers interesting for applications where multifunctionality, adhesion, metal complexation or thermal properties are key issues. C45 Development of immunostimulatory polymers for vaccine adjuvants Dr Sebastian Spain, Simon S. Briggs, Kerry Fisher, Len W. Seymour University of Nottingham Vaccination is one of medicine’s great success stories but there is still a need for new safe, stable and effective vaccines for emerging diseases. One major hurdle in the development of new vaccines is that inactivation of the antigen to improve safety and stability also reduces its immunogenicity and thus its efficacy. To alleviate this an additional immunogenic component, known as an adjuvant, is added to the formulation to increase efficacy. C47 alpha,omega-Dihydroxytelechelic Poly(Trimethylene Carbonate)s: Valuable Precursors to Polyester-bPolycarbonate and to Non-Isocyanate Poly(Carbonate Urethane)s Professor Sophie Guillaume, William Guerin, Marion Helou, Jean-Michel Brusson, Martine Slawinski, Jean-Francois Carpentier Institut des Sciences Chimiques de Rennes CNRS - Université de Rennes 1 - UMR 6226 The “immortal” ROP of trimethylene carbonate (TMC) catalyzed by inherently different systems (organocatalyst, Lewis acidic metallic salt such as triflate, discrete metallo-organic complex typically derived from Zn) has been developed. In particular, a,w-dihydroxytelechelic poly(trimethylene carbonate)s (PTMCs) thus synthesized, further allowed access to copolymers featuring polyester segments such as poly(lactide), as well as to poly(carbonate urethane)s as Non-Isocyanate PolyUrethanes (NIPUs). 60 C48 New Catalysts for epoxide/CO2 copolymerisation: Evidence for a dinuclear mechanism? Dr Michael Kember, Dr. Charlotte Williams introduce multiple functionalities, block copolymer with antifouling properties and activated pendent groups has been attached to the surface of IONPs. In-situ modification of the polymer coating has generated a library of multi-functionalized IONPs with moieties like fluorophore and drug complexing agent for specific biomedical application. C51 Imperial College London Using CO2 as a renewable source of chemicals is very attractive. This presentation will describe a series of dicobalt catalysts showing excellent activity for copolymerisation of cyclohexene oxide and CO2 at just 1 bar; amongst the most active reported at this pressure. The catalysts include a variety of neutral and anionic co-ligands, with correlation between donor strength and catalytic activity. This, combined with kinetic (FT-IR) and MS data will be used to propose an intramolecular dinuclear mechanism for the copolymerisation. C49 Oligomerization of Glycerol-Based Monomers and Functionalization Dr Phuoc Dien Pham, Vincent Lapinte, Sophie Monge, Yann Raoul, Jean Jacques Robin Solution phase self-assembly of polyferrocenylsilanecontaining triblock co-polymers Dr George Whittell, Alex Oliver, Paul A Rupar, Ian Manners School of Chemistry ABC triblock co-polymers containing a central poly(ferrocenyldimethylsilane) (PFDMS) segment self-assemble into cylindrical structures in a selective solvent for the end blocks. It is the crystallisation of the core-forming metalloblock that affords the elongated morphology, and also enables the length of the structure to be controlled by epitaxial growth. Unlike the case with PFDMS-containing diblock co-polymers, however, the A and C type coronal chains can microphase separate, leading to cylindrical nanostructures with patchy coronae. C52 Institut Charles Gerhardt UMR5253 - Equipe IAM- Université Montpellier 2 This communication deals with the development of glycerol derivatives: Solketal Acrylate (SolA) and Glycerol Carbonate Acrylate (GCA) in polymer field. The oligomerization by radical telomerization was investigated and using this methodology, several oligo(GC-stat-Sol)s were synthesized by varying GCA/SolA ratio. Otherwise, the orthogonality of the hydrolysis of cyclocarbonate and acetal groups was demonstrated under acidic and basic conditions. The third investigation concerns the functionalization of these polymers by functionalized telogen agents or by the reaction between amine and cyclocarbonate groups under mild condition. Polymer Logistics; Smart Polymers for Cargo Transport and Triggered Release. Dr Paul Wilson and David M. Haddleton University of Warwick A variety of synthetic techniques have been employed in the preparation of polymers designed to possess a molecular level of intelligence. Careful manipulation of polymer architecture leads to desirable attributes such as self assembly and encapsulation. Furthermore, incorporation of labile functional groups permits a degree of targeted, triggered, cargo release. C50 Versatile Multi-functionalization of Magnetic Nanoparticles for Biomedical Applications Mr Johan Sebastian Basuki, Thomas Paul Davis, Cyrille Boyer Australian Centre for Nanomedicine There is considerable interest in further development of superparamagnetic iron oxide nanoparticles (IONPs) for simultaneous multimodal imaging and targeted drug or siRNA delivery. In order to improve their colloidal stability and C53 Polyelectrolytes to engineer biodiagnostics Professor Gill Garnier Polyelectrolytes can increase functionality, sensitivity and selectivity of bio-assays for health applications. The stability of functional colloids in solution and the retention of enzymes, cells and antibodies as stable molecules/aggregates at the biointerface are engineered with polylelectrolyte adsorption. Polymer layer morphology and biointerface functionality are 61 controlled with polyelectrolyte chemical structure, molecular weight, charge density, concentration in solution, solution conditions and adsorption kinetics. 3 examples of bioassay presented. C54 Functionalized polylactides by cationic polymerization Dr Melania Bednarek and Malgorzata Basko Center of Molecular and Macromolecular Studies, PAS Synthesis of polylactide (PLA) functionalized with unsaturated groups have been performed via cationic ring-opening polymerization by activated monomer mechanism. PLAs with predetermined molecular weights containing propargyl or (meth)acrylic end groups at one chain end were effectively coupled with azides and thiols indicating the possibility of further functionalization for biomedical applications. C55 Micro-patterned polymer brushes for cell-based assays: from cell shape to micro-tissue assembly Dr Julien Gautrot, Britta Trappmann, John T. Connelly, Chunming Wang, Fiona M. Watt and Wilhelm T. S. Huck Queen Mary University of London Adhesion to extra-cellular matrix is an important determinant of cell biology, implicated in cell proliferation, differentiation of stem cells and programmed death. Physical parameters (matrix compliance, nano-scale topography, geometry of ligand distribution) modulate such adhesive signals. We explored how the geometry of matrix adhesions controls the differentiation of epidermal stem cells and their assembly in multi-cellular structures (micro-tissues) using polymer brush micro-patterns. C56 Glycopolymers synthesized by RAFT and NMP for Lectin Recognizable Biomaterials Professor Laurent Billon, P. Escale, S.R.S. Ting, L. Rubatat, M. Save, M. Stenzel IPREM EPCP In recent few years glycopolymers (i.e. polymers carrying pendant carbohydrate moieties) have received increasing attention due to the numerous biological mechanisms in which carbohydrates are implicated such as cell to cell recognition, inflammation, signal transmission and infection. These polymers could be also used for drug delivery nanoreactors, radio-labeled sugar-nucleotide donors and cell surface receptor. The purpose of the present study is to synthesize amphiphilic gradient and block copolymers by Reversible Addition Fragmentation Transfer or Nitroxide Mediated Polymerizations using a carbohydrate based galactose monomer (AcGalEA) and styrene (Sty). The final aim is to compare the properties of the copolymers depending on their microstructure to self-assemble into Honeycomb films or in aqueous media. The carbohydrate moiety will provide a bioactivity of the polymer film or micelles and the hydrophobic polystyrene part is required for the honeycomb film formation by the Breath Figure approach or as sticker block for micellization. C57 The Importance of Homogeneity in PEGylated Biologics Dr Matthew Bird PolyTherics Ltd The physicochemical and clinical properties of therapeutic proteins can be enhanced by the covalent attachment of poly(ethylene glycol), PEGylation. Site-specific PEGylation offers a route to homogenous products that are easier to purify and characterise than randomly PEGylated therapeutics. Site-specific conjugation methods are often more efficient than traditional PEGylation techniques potentially lowering manufacturing costs. Presented are three site-specific PEGylation technologies that have been developed to facilitate production of homogeneous conjugates. C58 The Effect of the Acid/Base "Switchable" Dithiocarbamate Z-Group Substituent on RAFT Polymerization Dr Daniel Keddie, Carlos Guerrero-Sanchez, Graeme Moad, Roger J. Mulder, Ezio Rizzardo and San H. Thang CSIRO Materials Science and Engineering Acid/base switchable dithiocarbamates offer a high level of control over polymerization of both MAMs (i.e. MMA, MA, DMAm, S) and LAMs (i.e. VAc, NVC, NVP) and allow access to polyMAM-block-polyLAM copolymers of low dispersity. The study of new agents of this class bearing Z-substituents with differing electronic demand has provided insight into the effect of structure on chain-transfer kinetics and allowed the design of more effective RAFT agents for control over the polymerization of both MAMs and LAMs 62 C59 Polymer-functionalized Janus silica particles Ms Dafni Moatsou and Vamvakaki M University of Crete We herein report the synthesis of sub-micron sized Janus silica particles comprising a polymer-grafted and an aminefunctionalized hemisphere. A hydrophobic, poly(methyl methacrylate), and an ionizable, pH- and temperatureresponsive, poly(2-(dimethylamino)ethyl methacrylate), polymer were grafted from the particles’ surface using surface-initiated atom transfer radical polymerization. The grafted polymer and the asymmetric colloids were characterized by GPC, TGA, DLS and SEM which suggested the formation of acorn- and snowman-like polymer grafted particles. spherical vesicles that was characterized using a range of methods, including laser light scattering, confocal laser scanning microscopy and TEM. The vesicular structure is potentially multifunctional in biomedical applications; namely, serving as a boron neutron capture therapy (BNCT) agent, a hydrophilic drug carrier, and a diagnostic imaging fluorescent probe. As expected, either cleaving the thiol-ene linked PEO chain by esterase or destroying carborane by neutron irradiation results in a dismantlement of such a vesicle structure to release its encapsulated drugs. Its potential biomedical applications have been in vitro and in vivo evaluated. Our preliminary results reveal that these small vesicles can be quickly taken up by cells and have an enhanced stability in blood stream so that their targeting to specific cancer cells becomes feasible. C62 Fluorescent Nanoparticles from PEGylated Polyfluorenes Dr Jonathan Behrendt Yun Wang, Laura Wall, Amita Joshi, Gareth Redmond, Helen Willcock and Michael L. Turner C60 Photo-initiation for the in-situ formation of hybrid silicavinyl networks Dr Tara Schiller, Wayne D. Cook, Cornelis Moorhoff, Loic Le Pluart Quentin Lognone, Linton Graetz, Katie Telavantos Monash University Polymer nanocomposites are integral to coatings, medical and opto-electronic devices. We have formed silica and nanostructures in situ, during the photopolymerization with monomers initiated by photochemical methods. By compositional and initiation control the relative rates of polymer and particle formation are used to guide the nanostructure and the thermal and optical electromagnetic properties of these materials are characterised. C61 Novel Boron-containing Vesicles for BNCT, Controlled Drug Release and Diagnostic Imaging Professor Gaojian Chen, Jingying Yang, Gang Lu, Pi Chu Liu, Qianjin Chen, Zuowei Xie, Chi Wu Soochow University New conjugate polymer was prepared by an efficient thiol-ene coupling of one carborane with a linear PEG chain and was further labeled with a fluorescence rhodamine dye. Such a novel polymer can associate in water to form narrowly distributed The University of Manchester A series of polyfluorenes that possess both hydrophilic (PEG) and hydrophobic (alkyl) solubilising side-chains have been synthesised and their formation into fluorescent nanoparticles via nanoprecipitation has been studied. The PEG/alkyl ratio of the polymers is shown to influence both the size and the optical properties of the nanoparticles formed. The size (>100 nm) and photostability of the nanoparticles make them ideal candidates for cellular delivery/bioimaging applications. C63 Programming the Morphology of Nanoparticles with Peptides, DNA and Enzymes Professor Nathan Gianneschi University of California, San Diego The morphology of nanoscale particles can strongly influence their physical and functional properties. Of great interest in our research is how morphology may be utilized to influence, switch and optimize the in vivo properties of nanoscale delivery vehicles for imaging and therapeutics applications. Therefore, we have set about developing a range of soft materials capable of switching morphology in response to specific biochemical stimuli. Herein, we present an approach that blends synthetic polymers with biopolymers to construct materials that respond selectively to particular enzymes including nucleases, proteases, kinases and phosphatases. 63 C64 A New Nitroxide for Nitroxide-Mediated Polymerisation at Temperatures Below 100 °C Professor Peter Lovell, Bencha Thongnuanchan and Neil R. Cameron C66 Anisotropic Particles as Surfactants Mr Nicholas Ballard and Stefan Bon University of Warwick University of Manchester This paper will describe research into new hydrophobic acyclic nitroxides for effecting NMP in miniemulsion at temperatures below 100 °C, which has led to discovery of a new nitroxide that gives very good control of styrene NMP at 70 °C and butyl acrylate NMP at 90 °C. Data from characterisation of the nitroxide-alkoxyamine dissociation equilibrium will be presented, together with results from homopolymerisations and block copolymerisations performed in solution and miniemulsion at 70–90 °C. C65 Hyperbranched Polymers synthesized from Catalytic Chain Transfer Polymerization for Macromolecular Design Dr Niels M.B. Smeets, Timothy F.L. McKenna and Todd Hoare McMaster University We demonstrate the utility of catalytic chain transfer polymerization (CCTP) for the synthesis of hyperbranched polymers, which can subsequently be used for macromolecular design. Core cross-linked micelle analogues are obtained from the synthesis of amphiphilic poly(methyl methacrylate-co-ethylene glycol dimethacrylate)-b-dextran (poly(MMA-co-EGDMA)-b-DEX) polymers. Injectable hydrogels are obtained from the combination of hyperbranched poly(oligo ethylene glycol methacrylate) (poly(OEGMA) carrying vinyl saturations (e.g. Apolymer) and synthetic or natural polymers carrying thiol functionalities (e.g. B-polymer). The effect of the molecular architecture on the phase transition temperature of the polymer and hydrogel are quantified. This work describes the use of particles as surface active agents in stabilising emulsions and foams. A computational approach to calculating the adhesion energy of particles to liquid-liquid interfaces is described and verified experimentally using chemically and shape anisotropic particles. C67 Self-Assembled Nanostructures of Luminescent Organoboron Block Copolymers and Star Polymers Professor Frieder Jaekle, Fei Cheng, Edward M. Bonder Rutgers University - Newark Luminescent materials are highly useful in optical and electronic devices, chemical sensors, and bioimaging agents. As a result of their novel properties organoborane-functionalized polymers have attracted particular interest. To integrate them into nanostructures is an important endeavor. We will report here on our recent success in the synthesis of luminescent organoboron block copolymers and star polymers via RAFT polymerization and discuss their emission properties and self-assembly into nanostructures, such as micelles, vesicles, and spindle-shape aggregates. C68 Permeability effects in polymersome-based artificial organelles Dr Iria Louzao Pernas, Jan C. M. van Hest Institute for Molecules and Materials, Radboud University Nijmegen Recently, polymersome based nanoreactors proved to be capable of entering cells by decorating the outer surface with targeting peptides. The catalytic activity of a model enzyme was shown to be preserved inside cells. We show the implementation of a therapeutic cascade reaction for counteracting oxidative stress in two types of polymersomes with different permeability. Both enzymes preserved the catalytic activity. However, differences in shell permeability have an influence in the diffusion of molecules across the polymersome membrane, leading to substrate selectivity. 64 C69 The Design of Profluorescent Nitroxide Based Sensor Materials Dr James Blinco, Dr Kathryn Fairfull-Smith copolymers, and discuss the remarkable effects of relative block content and overall molecular weight on the relative domain sizes. The elucidation of their internal structure through 2- and 3D cryoTEM and electron tomography studies will be presented, in addition to investigating the use of these bicontinuous aggregates as a novel polymeric template for biomimetic mineralization. Prof Steven Bottle C72 Queensland University of Technology Nitroxides are stable, free radicals with a number of unique properties. One of their recent applications is to covalently link them to a fluorescent moiety giving a switchable fluorometric probe. The ability of the nitroxide/fluorophore couple to act as a probe arises from the nitroxide’s ability to efficiently quench excited states both inter- and intra-molecularly. This presentation will demonstrate the synthesis of polymeric scaffolds adorned with profluorescent nitroxides that can then be utilised as fluorescent sensors for both chemical and physical changes. C70 Development of stimuli-responsive hybrid nanoparticles for advanced coatings applications, based on an ABCD type block copolymer Dr Nuno Rocha, Arménio C. Serra, Jorge F. J. Coelhoa Chemical Engineering Department, University of Coimbra A four-block copolymer was synthesized, from the combination of living radical polymerization and “click” chemistry reactions, to create innovative nanoparticles prepared via self-assembly for advanced coatings formulations. The copolymer was composed of a steric stabilizer segment, a responsive polymer, and a diblock hydrophobic core capable to coordinate metallic species. The self-assembly performance was evaluated as a function of the copolymer design (composition and molecular weight) and of the medium conditions (concentration, pH, temperature, solvent). C71 Single cyclized polymer: Beyond Flory-Stockmayer theory Dr Yu Zheng, Wenxin Wang Network of Excellence for Functional Biomaterials Controlled/living radical polymerization (CRP) is a widely used technique that allows the synthesis of defined polymer architectures through precise control of molecular weights and distributions. Here, we report the preparation of a new 3D single cyclized polymer chain structure from an in situ deactivation enhanced atom transfer radical polymerization (in-situ DE-ATRP) of multi-vinyl monomers (MVMs), which are conventionally used for the production of branched/cross-linked polymeric materials as defined by P. Flory and W. Stockmayer nearly 70 years ago. We had further developed the knot polymer architecture toward to non-viral gene vector. As numerous reports in literature demonstrate that a higher transfection performance can be achieved through the branched architecture, it can be reasonably hypothesized that the new knotted structure of single cyclized polymer chains will out-perform currently available polymer structures in terms of efficacy, cell viability and scalability. We demonstrate that it is possible to kinetically control both the macromolecular architecture and the critical gel point in the polymerization of MVMs, which is beyond the scope of F_S theory. The broad range of novel nanosize 3D polymeric materials that can be designed and produced from the numerous available multivinyl monomers will have significant applications in a wide range of different fields. These cyclized structures, previously unachievable theoretically and experimentally, will open new avenues for the field of gene delivery. C73 Complex Polymeric Bicontinuous Nanospheres as Templates for Mineralization Hyperbranched polymers for polymer tharanostics Dr Beulah McKenzie, Heiner Friedrich, Fabio Nudelman, Paul Bomans, Simon Holder and Nico Sommerdijk Dr Kristofer Thurecht, Idriss Blakey, Daniel Coles, Oliver Squires, Barbara Rolfe, Cameron Alexander and Andrew K Whittaker Eindhoven Technical University Australian Institute for Bioengineering and Nanotechnology This presentation will present the formation of novel bicontinuous nanospheres from semi-crystalline block 65 We discuss the properties of hyperbranched polymers and show how they offer a unique approach to designing theranostics: they combine many different functionalities (and hence chemistries) into a single molecule; their structural nonuniformity, yet highly controlled size, volume and intramolecular dynamics facilitates structural rearrangements not possible in many other drug delivery analogues. We present the synthesis and characterisation of such polymers and describe both in vitro and in vivo data on the application of these molecules as drug delivery devices and as molecular imaging agents. C74 Synthesis and Characterization of "Glycopolyurethanes Dr Christina Ott, Christopher D. Easton, Thomas R. Gengenbach, Sally L. McArthur, and Pathiraja A. Gunatillake The micelle is composed of a soft corona of PEO enabling slight deformation under compression and a relatively hard core of PSAN, maintaining the micelle’s structural integrity by trapping the copolymer chains in a frozen morphology at room temperature. The links between micelles are formed by ABA triblock copolymer bridges with A blocks localized into two different micelle cores. These spherical micelles arranged in such a fashion so as to have interstitial free volume bringing nanoporosity to the film. Due to deformable nature of the individual micelle combined with dynamic copolymer bridges, the nanomaterial can be reversibly or irreversibly compressed depending on the applied pressure leading to a wide range of accessible porosities. When a perforation mimicking “damage” is created, the compression of the micelle assembly forces the perforation fragments to get back to their original position against the overall pressure, leading to almost 100% recovery of the original performance. CSIRO Materials Science and Engineering C76 Polyurethanes (PU's) have proven to be an essential class of synthetic polymers due to their versatility and ability to tune the material properties by the choice and composition of the starting materials. For this purpose, carefully chosen chain extenders possessing alkene and alkyne functionalies, respectively, were applied for step-growth polymerization processes. Depending on the utilized chain extender, modification of the polymers was achieved by performing either copper catalyzed Huisgen 1,3-dipolar cycloaddition or thiol-ene click reactions. Polyurethanes with glucose and galactose moieties have been prepared and characterized by means of nuclear magnetic resonance spectroscopy, gel permeation chromatography, infrared spectroscopy, X-ray photoelectron spectroscopy and water contact angle measurements. Preliminary cell viability tests have shown that these polymers are non cytotoxic. C75 Free-Standing Nanoporous Materials based on Selfassembled ABA Block Copolymer Micelles Dr Trang Phan, Tyagi, P. ; Deratani, A. ; Bouyer, D. ; Bonniol, G. ; Cot, D. ; Quémener, D. ; Bertin, D. ; Gigmes, D. Aix-Marseille University - Institut de Chimie Radicalaire - UMR 7273 The triblock copolymer poly(styrene-co-acrylonitrile)-bpoly(ethylene oxide)-b-poly(styrene-co-acrylonitrile) (PSAN-bPEO-b-PSAN) was prepared via the Nitroxide Mediated Polymerization method and characterized. The material relies on the 3D dynamic self-assembly of flower-like block copolymer micelles in selective solvent having individual diameter of 50 nm. Responsive Polymers for Simultaneous Interference with Bacterial Quorum Sensing and Adhesion Dr Francisco Fernandez-Trillo, Xuan Xue, Cheng Sui, Nigel Halliday, Klaus Winzer, Steve Howdle, Benjamin G. Davis, Cameron Alexander School of Pharmacy, University of Nottingham Synthetic polymers can be very powerful tools in the field of bacterial infection. For instance, synthetic polymers have been shown to bind and sequester bacteria via multivalent ligand display, while at the same time avoiding selection pressure and resistance invoked in bacteria by antibiotic. Inhibition of QS is itself a potential further method of controlling bacterial infection. We have recently described the synthesis of novel linear polymer with the ability to both bind to the surface of Vibrio Harveyi while at the same time interfere with its AI-2 signalling network. This new materials open the pathway to the development of novel polymeric ;dual-action; antibacterial therapies. In this communication we wish to present our current efforts on the understanding of the precise mechanism by which these materials interfere with bacteria and the effects of material architecture. . C77 Frozen to dynamic self-assembled block copolymers Dr Olivier Colombani, Celine Charbonneau, Christophe Chassenieux, Elise Lejeune, Miriam De Souza Lima, Taco Nicolai PRES LUNAM, Université du Maine 66 Amphiphilic block copolymers self-assemble in water into nanostructured aggregates. However, because of a high interfacial tension between the hydrophobic block and water, “frozen”, i.e. out-of-equilibrium, structures are often formed. By introducing acidic hydrophilic units in the hydrophobic block(s) of amphiphilic diblock and triblock copolymers, frozen aggregates were rendered dynamic. Light scattering and rheology experiments revealed that the aggregation number and dynamics of exchange depend dramatically and reversibly on the pH. C78 Design and synthesis of multifunctional polymeric nanoparticles C80 Biodegradable stimulus-responsive block copolymers prepared from disulfide-functional cyclic monomers Dr Jeppe Madsen Irene Canton, Russell Pearson, Steven P. Armes, Giuseppe Battaglia University of Sheffield Fluorescently labelled biocompatible block copolymers based on poly(2-(methacryloyloxy)ethyl phosphorylcholine) for in vitro and in vivo studies have been prepared using ATRP. Examples of three different labelling strategies are presented here: One approach is to use a fluorescent ATRP initiator, which leads to polymers with one fluorophore per chain. A second approach is to use a fluorescent comonomer. This will give polymers with statistically incorporated fluorophores. A third approach is to attach the fluorophore after polymerisation using thiol-ene ‘click’ chemistry. Professor Jianzhong Du Tongji University We aim to design and synthesize multifunctional nanoparticles by self-assembly of amphiphilic polymers. A new class of effective UV-screening TiO2 nanoparticles have been prepared by sol-gel reactions within the hydrophobic core of triblock copolymer micelles, which also showed good catalytic activities for the degradation of dyes. We also prepared polymer micelles with good antimicrobial activity. Finally, we report the preparation of theranostic nanoparticles which have ultrasensitivity for MRI contrast and the ability for drug delivery with non-cytotoxicity, high biocompatibility and excellent colloidal stability in aqueous media. C79 Glycopolymer-stabilized nanostructures by aqueous RAFT dispersion polymerisation Dr Vincent Ladmiral, M. Semsarilar and S.P. Armes University Of Sheffield Glycopolymer-based nanoparticles are highly desirable for applications in biotechnology. However, only a few preparation methods have been reported so far. We present a new two-step approach to prepare colloidal glycopolymer nanoparticles: (1) RAFT polymerisation of a novel glyco-based methacrylate; (2) chain extension of this glycopolymer precursor using 2hydroxypropyl methacrylate via RAFT aqueous dispersion polymerisation. We also report preliminary results of the interactions of the resulting self-assembled diblock copolymer nano-objects with lectins. C81 Multifunctional poly(2-oxazoline)s - side chain functionalization and polymer post-modification by efficient reactions Dr K Kempe, Richard Hoogenboom, Ulrich S. Schubert Friedrich-Schiller-Universität Jena Poly(2-oxazoline)s are a perfectly suited class of polymers for the preparation of well-defined (co-)polymers, allowing the integration of a wide range of functionalities. The incorporation of manifold conjugation sites in the polymer can be achieved by both side group and end group functionalization, whereby the polymer properties can be tailored by the nature of the side chains. Besides a defined structure design by preparation of hydrophilic and hydrophobic blocks as well as the fine-tuning of the crystallinity, functional groups can be incorporated and exploited for subsequent efficient modification reactions, e.g. for “click chemistry”. In this context a variety of polymer systems could be synthesized encompassing low glass transition materials, triblock terpolymers as well as functional nanoparticles, glycopolymers, and block copolymers. In particular the latter were obtained applying different efficient coupling strategies, such as thiol-ene and Diels-Alder cycloaddition reactions. Thus, the wide scope and the versatility of poly(2-oxazoline)s as a polymer class providing multiple ways for a straightforward tuning of the polymer properties and, thus, the application in various research fields is demonstrated. 67 motivations underpinning the work. This will include their synthesis and analysis of their photo-degradation properties. POSTERS P1 Epoxide Microspheres: A Versatile Material for Various Surface Modifications P4 Functional Redox-Sensitive Hydrogels and Nanogels through Enzymatic Cross-Linking Dr Andrew Vogt Michael Kaupp, Vanessa Trouillet, Alexandra M. Greiner, Udo Geckle, Leonie Barner, Thorsten Hofe, Christopher Barner-Kowollik Smriti Singh, Fuat Topuz, Krystyna Albrecht, Martin Moeller, Juergen Groll Karlsruhe Institute of Technology (KIT) Institute for Interactive Material Research, DWI an der RWTH e.V Porous polymeric microspheres made of glycidyl methacrylate serve as a versatile material for surface modification with various functionalities. The functionalization of polymeric microspheres with molecular boronic acid via direct epoxide ring opening, and functionalization with cyclopentadiene for subsequent RAFT-HDA ligation with glycopolymers will be highlighted. Both quantitative and qualitative analyses were performed on the functionalized microspheres with various techniques. Redox-sensitive materials have dramatically gained interest over the last years.Disulfide cross-linked networks are particularly appealing, as disulfides are structure-forming groups in proteins as well as in natural processes and conditions in cells exist that allow reductive scission of these covalent links. Thiol functionalised linear poly(glycidol) (Mn = 6100 g/mol, HS-PG) and six arm, star shaped prepolymers with copolymerized ethylene oxide and propylene oxide in the ratio 4 to 1 (Mn = 12,900 g/mol, HS-sP(EO-stat-PO)) were chosen as hydrophilic and cytocompatible gel precursors. P2 Functionalised polymers with novel lubricating regimes Athina Anastasaki, T. Smith, D. Price, D.M. Haddleton P5 Synthesis of Copolymers of PEI-b-POEGMA via ATRP Aaron Kliene Simon Holder, Tom Ashton, Nico Sommerdijk, Seyda Bucak, U. Ecem Yarar University of Warwick Oil soluble polymers have been synthesized by CCT polymerisation and functionalised by thio-Michael addition P3 RAFT Hydrogels with Photo-degradable Properties Dr Francesca Ercole, Richard A. Evans, John Forsythe Monash University Polymers that can respond on demand to an external stimulus continue to attracted interest in scientific disciplines. Light is a useful stimulus since it can be localized both in time and space and can be triggered externally. Traditionally an o-nitrobenzyl ester has been used as a photosensitive protective group for carboxylic acids in the synthesis of peptides, polysaccharides and nucleotides. It cleaves irreversibly with UV light (365 nm) to liberate a carboxylic acid and an aromatic nitroso compound. A notable application of its photo-labile chemistry in polymer science is a hydrogel whose cross-linking density and storage modulus can be manipulated externally. In this poster we will highlight some of the strategies that we have used to incorporate o-nitrobenzyl esters into hydrogels and the University of Kent Reaction conditions for amide initiated ATRP of oligo[(ethylene glycol) methyl ether] methacrylate (OEGMA) were optimized introducing control, confirmed by standard first order kinetic plots. This led to the synthesis of copolymers from branched polyethyleneimine (PEI) macroinitiators.PEI-POEGMA copolymers show promise as stabilisers for iron oxide nanoparticles in MRI and also retain DNA comlpexation properties allowing routes to targeted gene delivery. P6 Synthesis and Assembly of Anisotropic Hematite@SilicaPolymer Colloids Adam Morgan and dr. ir. Stefan A.F. Bon The University of Warwick Anisotropic core-shell hematite@silica particles were functionalized with a methacrylate group and used as seed in the dispersion polymerization of styrene, and styrene-co-butyl acrylate. The effect of the reaction conditions on the particle 68 morphology have been investigated, and structure/property relationships of the assembled particles have been studied. P7 P9 Commercial Branched Addition Polymers: their use in Coatings, Inks, Membranes and Emulsifiers Preparation and self-assembly of hybrid polymers containing polyhedral oligomeric silsesquioxane (POSS) Dr Roz Baudry, Paul Findlay, Julien Marquiant, Brodyck Royles, Anne-Laure Sanoner and Neil Simpson Dr Weian Zhang Hydra Polymers Ltd School of Chemistry, University of Leeds Hydra Polymers Ltd is a technology start-up company based in Liverpool which was incorporated to exploit high molecular weight branched addition polymers for commercial applications. These materials are manufactured from commercial grade monomers using standard plant. The main advantages of these polymers stem from their high degree of branching; this imparts low solution or melt viscosity, high solubility, high surface interactions among other benefits. Branched addition polymers have a wide range of applications, including paints & coatings, inks, adhesives, fuel & lubricant additives, water treatment, agrochemicals and pharmaceuticals. Recently, hybrid polymers containing polyhedral oligomeric silsesquioxane (POSS) have attracted great attention due to their unprecedented properties. POSS-containing hybrid polymers with unique architectures can be prepared using advanced polymer synthesis protocols such as living polymerization and “click chemistry”. These hybrid polymers could self-assemble into a rich variety of morphologies. For example, hemi-telechelic POSS-containing hybrid poly(acrylic acid) (PAA) self-assembles in water into a structure that is different from a simple core-shell micelle with POSS molecules as the core and PAA as the shell. Apparently aggregates are formed where the POSS moieties are dispersed in the particle. These POSS-containing hybrid polymers can be potentially applied in drug delivery and many other fields such as catalysis and microelectronics. P8 Directional Freezing and Frozen UV initiated Polymerisation to Prepare Aligned Porous Material with Enhanced Mechanical stability, Conductivity and Functionality. Michael Barrow Dr Ali Entimimi, Dr Adham Ahmed, Prof. Peter Myers, Haifei Zhang University of Liverpool A new method for preparing aligned porous material is demonstrated. Directional freezing and frozen UV initiated polymerization are used to prepare highly cross-linked material with enhanced mechanical stability, conductivity and functionality. The highly cross-linked material has been evaluated as a stationary phase for HPLC and can be further modified with graphene sheets and conducting polymer PEDOTPSS to achieve conductivity of 1.9 x 10-4 S cm-1 and 5.2 x 10-6 S cm-1 respectively. Using various types of methacrylate monomers enables production of aligned porous materials with different functionality such as aligned porous stimuli responsive hydrogels and aligned porous structures coated with silver nanoparticles. P10 Microporous Copolymers for Increased Gas Selectivity Thanchanok Ratvijitvech Robert Dawson, Matthew Corker, Andrew I. Cooper and Dave J. Adams University of Liverpool Microporous organic polymers (MOPs) are a class of porous materials made from organic monomers possessing high thermal and chemical stability and with surface areas up to 6000 m2/g. Friedel-Crafts alkylation of aromatics with formaldehyde dimethyl acetal as crosslinker can produce materials with surface areas over 1000 m2/g from bulk cheaply available chemicals. The co-polymerisation of aniline with benzene produces a series of MOPs for which the surface area and carbon dioxide uptakes can be tuned by statistical copolymerisation leading to enhanced CO2/N2 selectivity. P11 Synthesis and biological investigation of polymer-coated iron oxide nanoparticles for stem cell labelling. Anita Peacock Solène I. Cauët, Arthur W. Taylor, Patricia Murray, Jonathan V. M. Weaver, Dave J. Adams and Matthew J. Rosseinsky University of Liverpool Polymer-coated inorganic nanoparticles were successfully prepared via grafting of well-defined end-functional polymers 69 prepared by ATRP to iron oxide particles. With a high polymer coverage, the nanoparticles demonstrated good dispersability and colloidal stability in PBS, did not elicit any obvious toxic effects and were readily taken up by stem-cells confirming their potential for biological applications in general and cell-labelling in particular. latexes was made via semi-seeded emulsion polymerisation of MMA and BA in varying ratios to adjust the glass transition temperature, Tg. GARField Nprofiling was used to track the water distribution in drying films, and AFM to characterise particle deformation. The results indicate water entrapment in low Tg latexes due to “skin” formation P12 P14 Aluminium quinolinate complexes: New iso-selective initiators for rac-lactide ring-opening polymerisation One-pot, single-component synthesis of emulsiontemplated hybrid inorganic–organic polymer capsules Clare Michelle Bakewell Mike Haaf, Andrew J.P. White, Nick J. Long, Charlotte K. Williams Rachel Harbron, Tom O. McDonald, Steve P. Rannard, Paul. H. Findlay and Jonathan V. M. Weaver Imperial College London Imperial College London Polylactide, PLA, is a commercially produced material showing considerable promise as a sustainable replacement for petrochemicals.1 It is produced by the ring-opening polymerization of lactide. One significant challenge for PLA synthesis is the control of stereochemistry during ring-opening. In particular, producing isotactic PLA from racemic lactide (racLA) is both highly desirable from a practical point of view, as it has better thermal-mechanical properties than atactic PLA, but it is also a significant academic challenge as there are very few iso-selective initiators. This presentation will describe the synthesis, characterization and polymerization catalysis of a series of new aluminium complexes, ligated by quinolate ligands, which are iso-selective initiators. Thus, the preparation and characterization, using spectroscopy and X-ray crystallography, of various new bis(5,7-dihalide-8-oxy-2-methylquinolinate) aluminium ethyl species will be discussed. The new complexes are active initiators for the ring-opening polymerisation of racLA, and show good/moderate isoselectivities (Pi = 0.62-0.76). The initiators’ polymerization kinetics, polymerization control and stereocontrol will be discussed. Various derivatives and the structure-activity relationships will be described, shedding light on the mechanism(s) by which stereocontrol may occur. We describe a robust strategy to encapsulate actives and fabricate hollow micron-sized hybrid polymer capsules. Our capsule fabrication strategy exploits a novel multi-purpose amphiphilic branched copolymer that uniquely serves as both emulsifier and cross-linker. The strategy has the key advantages of: (i) being single-component, (ii) producing stable droplets which can be cross-linked on-demand and (iii) providing additional surface functionalization P13 The effect of polymer viscoelasticity on the drying characteristics of acrylic latexes Farai Carter Malcolm Chainey, Ian Millichamp, Radoslaw M Kowalczyk, Joseph L Keddie University of Surrey P15 Novel Bimetallic Catalysts for CO2/Epoxide Copolymerisation Reactions Prabhjot Saini, Michael R. Kember, Antoine Buchard, Fabian Jutz, Charlotte K. Williams Imperial College London With increasing concerns about fossil fuels not being sustainable in the longer term, recycling waste CO2 to produce polycarbonates is highly desirable. These polymers are used in everyday life (home insulation, fibres, adhesives and construction). This poster presentation will describe a new class of bimetallic complexes coordinated by macrocyclic ligands. These complexes are highly active in CO2/cyclohexene oxide copolymerisation reactions, at 1 bar CO2 pressure. They are also robust and have high selectivities towards polymer formation. P16 Withdrawn Protective coatings are applied over a wide range of climatic conditions, posing a challenge for waterborne systems, which either fail to dry or do so too quickly. This study determines the effect of particle deformation on the water loss. A series of 70 P17 Mechanism and Applications of the Solvent Evaporation Process from Emulsion Droplets Roland H. Staff, David Schäffel, Kaloian Koynov, Katharina Landfester, Daniel Crespy P19 Synthesis and characterization of polyurethanes containing maltose for selective determination of dopamine in the presence of high levels of ascorbic acid and uric acid Busra Aksoy, Suleyman Koytepe, Aziz Pasahan, Turgay Seckin Max Planck Institute for Polymer Research We present here new insights in the preparation and application of the solvent evaporation process from emulsion droplets: - Dual color fluorescence correlation spectroscopy is a suitable method to quantify the coalescence occurring in such systems; New anisotropic and patchy stimuli-responsive nanoparticles can be prepared from crystalline polymers or from block copolymers, for which the effect of confinement on their morphologies was investigated. P18 Surface Functionalization of Carbon Nanotubes for Nanocomposite Professor Turgay Seckin and Ayber Yildirim Inonu University Carbon nanotubes (CNTs) are cylinder-shaped molecules with a few nanometers radius and length up to centimeters. The walls of these tubes are made up of a hexagonal lattice of carbon atoms analogous to the atomic planes of graphite. In this study, single-wall carbon nanotube (SWCNT) composites were prepared and analyzed from various polymers. Firstly, SWCNT was surface modified with sol-gel techniques. Different fonctionalized surfaces (hydroxyl, chloro, bromo and carboxilic acid) achieved by various silane. The functional groups on its surface were characterized by scanic electron microscope, transmission electron microscope and FTIR spectroscopy. In a second step, novel CNT nanocomposites were prepared by reacting the required ratios of surface modified CNTs and various polymers. The prepared nanocomposites were characterized for their structure, morphology, and thermal behavior employing Fourier transform infrared spectroscopy, scanning electron micrograph, X-ray diffraction, and thermal analysis (DTA/TGA/DSC) techniques. A chemical functionalisation of SWCNTs can be a useful tool to improve the dispersion of the nanotubes in an polymer system. These interactions should be strong enough to potentially increase the thermally properties of carbon nanotube reinforced polymer-composites. Inonu University Dopamine (DA) is one of the natural catecholamines. It is an important compound for message transfer in the mammalian central nervous system. In this study, we report the synthesis, characterization and behavior of biodegradable of the polyurethanes containing maltose as a simple, sensitive, reliable and cheap method for the determination of DA in the presence of high concentration of the electroactive AA and UA and non electroactive interferents. A series of biodegradable polyurethanes (PUs) are synthesized by polycondensation of the maltose - ethylene glycol (EG) - diphenylmethane diisocyanate (MDI) system. The voltammetric results demonstrated that polymer electrode by polyurethane solutions containing % 3 maltose was allowed penetration of dopamine while blocking the permeation of high levels of ascorbic acid (AA) and uric acid (UA) through polymeric film in 0.1 M PBS. Therefore, it has been claimed that this polyurethane electrode can be used successfully as a dopamine-selective membrane in the presence of the mentioned electroactive and non-electroactive interferents. P20 Preparation of Polyimide Based Polyoxomethalates and Structural Characterization Sema Vural and Turgay Seckin Inonu University Polyoxometalates (POMs) are anionic d0 metal-oxygen clusters. In the past decades, organic-inorganic hybrids based on polyoxometalates (POMs) and various metal-organic complexes have been reported. In this study new POM compounds have been synthesized from various metal salts and ammonium molybdate under hydrothermal conditions. Then, the modified polyoxometalate was physically blended with poly(amic acid) and the blends were thermally imidized to form polyimidepolyoxometalate composites. The X-ray diffraction (XRD) analysis indicates that the polyoxometalate clusters don’t agglomerate in the composite, suggesting that the blending leads to improved compatibility between the kapton matrix and the polyoxometalate. The SEM and EDX studies on the composite films reveal that the polyoxometalate clusters are 71 well dispersed in the kapton matrix and showed exceptional catalytic properties in oxidation. P21 Metallo-Supramolecular Materials based on TerpyridineFunctionalized Polyhedral Silsesquioxane laser microscopy and scanning electron microscopy (SEM). The experimental results show that PAA was contained inside the poly(St-co-DVB) shell and was released upon the application of mechanical stress. By varying the concentration of surfactant in the oil phase it was possible to obtain both porous and nonporous poly(St-co-DVB) shells and the the ion exchange potential was demonstrated using energy-dispersive X-ray spectroscopy (EDS). Dr Suleyman Koytepe, M. Hurşit Demirelb, Ahmet Gülteka, Turgay Seçkin Inonu University Stimuli responsive materials have gained great interest in recent years since these materials are able to exhibit a dramatic change in their properties in response to the application of an environmental stimulus, such as light, temperature, mechanical stress, pH, ionic strength, solvent polarity, electric fields, biological and chemical analytes, etc. This study, Well-soluble high molecular weight coordination polymers were prepared by complexing terpyridine-functionalized polyhedral silsesquioxane ligand with Ni (II), Co (II) and Cu (II) ions, respectively. A series of stimuli-responsive metallo-supramolecular gels have been prepared from octa-functionalized polyhedral silsesquioxane based on terpyridine. metallo-supramolecular polymers have been developed using the coordination of this ligand monomer to various metal ions(Ni (II), Co (II) and Cu (II) ions), Synthesized materials were characterized by UV-vis and FTIR spectroscopy, viscosity, TGA. The gel morphology, gel structure, stimuliresponsive properties, particularly rheological properties, are examined as functions of metal ion composition, gel concentration, pH and salt content. The behavior of these materials shows extreme sensitivity to their preparation conditions, indicative of their highly stimuli-responsive nature. P22 Hydrophilic-hydrophobic core-shell particles by suspension polymerisation Cristian Menzel Prof S.G.Yeates University of Manchester A novel strategy based on water-in-oil-in-water (W/O/W) double-emulsion templating has been used for the preparation of hydrophilic-hydrophobic core-shell particles with controllable porosity. Specifically polyacrylic acid (PAA) hydrogel was encapsulated into a poly(styrene-co-divinylbenzene) (poly(St-coDVB)) shell using free radical suspension polymerisation. In order to improve the formation of core-shell structures the coalescence of the internal W/O was promoted by means of an osmotic gradient. The spherical microcapsules thus obtained were characterized using Raman confocal microscopy, confocal P23 Synthesis of Poly(phenylene vinylene)s via Ring Opening Metathesis Polymerisation Benjamin Lidster Chin-Yang Yu, Andrew C. Spring, Madeleine Helliwell and Michael L. Turner The University of Manchester A synthetic route to poly(phenylene vinylene)s has been developed involving the living ring opening metathesis polymerisation of highly strained cyclophanediene monomers. The approach produces linear polymers with well defined molecular weights and end groups as well as the absence of any non conjugated defects along the polymer backbone. The living nature of the polymerisation has further been demonstrated in the synthesis of conjugated block copolymers. P24 Synthesis of Alkali-Soluble Resins and their use as Colloid Stabilizers in Emulsion Polymerisations Shicheng Li and Peter A. Lovell University of Manchester Alkali-soluble resins (ASRs) are hydrophobically-modified anionic polyelectrolytes of molecular weight ranging from 500-20,000. Catalytic chain transfer (CCT) polymerization is an efficient way to control molecular weight for the polymerizations of αsubstituted monomers, generating polymers with terminal double-bonds. The paper will report synthesis of ASRs by CCT free-radical polymerizations for use in studies of their behaviour as colloid stabilizers in emulsion polymerizations. P25 TBC Joseph Wheeler University of Manchester TBC 72 P26 with 2-azidoethylamine, a species containing both azide and primary amine functional groups. Controlled synthesis of polymer nano-clusters in nonpolar media Sean Butterworth S.G.Yeates, B.Saunders, H.Wilson, L. Farrand School of chemistry, University of Manchester The field of e-paper / flexible display / digital signage represents a significant growth opportunity for all parts of the display manufacturing value chain with electrophoretic displays being a viable candidate, due to their low power consumption, paperlike appearance and daylight readability. We have developed a new approach to the synthesis of shape heterogeneous monodisperse particles suitable for use in electrophoretic displays as well as in photonic crystals. Here we report the controlled synthesis of poly(methyl methacrylate) nano-clusters in a low k dielectric medium. P27 Reversible addition-fragmentation chain transfer polymerization of vinyl chloride P29 Soft-Soft Nanocomposite Coating Materials produced by Emulsion Polymerisation Elizabeth Eaves and Peter A. Lovell University of Manchester This paper will report on the challenge of applying an innovative ‘soft-soft nanocomposite’ strategy for the design and synthesis of high-performance water-borne pressure-sensitive adhesives to developing robust and durable high-performance waterborne surface coatings. P30 Thermoresponsive Cationic Graft Copolymers Containing 2-(2-Methoxyethoxy)ethyl Methacrylate Side Chain Nur Nabilah Shahidan, Ruixue Liu, Francesco Cellesi, Cameron Alexander , Kevin M. Shakesheff and Brian R. Saunders Carlos Abreu, Patrícia V. Mendonç, Arménio C. Serra, Jorge F. J. Coelho, Anatoliy V. Popo, Ganna Gryn’ova, Michelle L. Coote and Tamaz Guliashvili University of Coimbra - Chemical Engineering Department Controlled/”living” radical polymerization of VC via RAFT process is achieved for the first time. The cyanomethyl methyl(phenyl)carbamodithioate was found to be an efficient RAFT agent enabling the CLRP polymerization of VC monomer under certain experimental conditions. Two different radical initiators, having very distinct half-life times at room temperature, were employed in this study. The “livingness” of the PVC was also confirmed by a successful re-initiation experiment. The suitability of the RAFT agent was also confirmed via high-level ab initio molecular orbital calculations. P28 University of Manchester We report an improved thermoresponsive graft copolymer prepared from 2-(2-methoxyethoxy)ethyl methacrylate using atomic transfer radical polymerization. All copolymers existed as unimolecular micelles at 20°C. The hydrodynamic diameters decreased with temperature (repeating units range: 20-100) and underwent reversible aggregation. Electrostatic repulsion played an important role in dispersion stability at temperatures greater than cloud point temperatures. Our new cationic copolymers retained positive charge and have higher zeta potentials at 37°C. P31 Effects of Trehalose Polycation End-group Functionalization on Plasmid DNA Uptake and Transfection A study of pH-responsive primary amine microgels prepared using click chemistry Dr Kevin Anderson, Antons Sizovs, Mallory Cortez, Theresa M. Reineke Robert Farley and Dr Brian Saunders The University of Minnesota University of Manchester In this study, we have synthesized six analogs of a trehalosepentaethylenehexamine glycopolymer (Tr4) that contain (1A) adamantane, (1B) carboxy, (1C) alkynyl-oligoethyleneamine, (1D) azido trehalose, (1E) octyl, or (1F) oligoethyleneamine end groups and evaluated the effects of polymer end group chemistry on the ability of these systems to bind, compact, and The synthesis of amine functionalised microgels with high amine contents has not yet been achieved. This approach takes advantage of the Cu(I) click chemistry reaction between alkynyl and azide species by reacting an alkynyl functionalised microgel 73 deliver pDNA in cultured HeLa cells. The polymers were all found to bind and compact pDNA at similarly low N/P ratios and form polyplexes with plasmid DNA. This study yields insight into how very subtle structural changes in the polymer chemistry such as end groups can yield very significant differences in the biological delivery efficiency and transgene expression of polymers used for pDNA delivery. P32 Synthesis of poly(dimethyl(methacryloyloxy)methyl phosphonate)-based materials by RAFT Benjamin Canniccioni, Sophie Monge, Ghislain David, JeanJacques Robin Institut Charles Gerhardt UMR5253 CNRS - Equipe IAM Université Montpellier 2 Phosphorus containing copolymers are very promising compounds as their range of applications is broad. To date, only limited examples described the synthesis of phosphorus-based materials by controlled radical polymerization techniques. In this contribution, we reported the synthesis of well-defined poly(dimethyl(methacryloyloxy)methyl phosphonate)-based materials by RAFT, such as poly(methyl methacrylate)-bpoly(dimethyl(methacryloyloxy)methyl phosphonate) (poly(MMA-b-MAPC1)) block copolymers, for instance. Thanks to their high phosphorous content, these new diblock copolymers appeared to be valuable for anticorrosive coating. P34 Synthesis and self-assembly of poly(methyl methacrylate-b-m-triphenylamine) block copolymers Sarah Mastroianni, Joseph P. Patterson, Rachel K. O’Reilly, Thomas H. Epps, III University of Delaware Block copolymers containing poly(m-triphenylamine) (PmTPA) and poly(methyl methacrylate) (PMMA) were synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization. The neat diblock copolymers self-assembled into lamellar and hexagonally packed cylinder morphologies. The melt-state phase behavior of this system was explored further using blends of diblock copolymers and constituent homopolymers. P35 A comparison of conventional vs microwave heating in the oligonerisation of MMA using CCTP Kevin Adlington University of Nottingham A comparison of conventional vs microwave heating in the oligonerisation of MMA using CCTP P36 P33 Self-assembly of poly(vinyl alcohol)-b-poly(vinyl acetate) block copolymers: toward new drug delivery systems? Bacterial Autonemesis Templating Polymers For Cell Sequestration Julien Muller, Sophie Monge, Jean-Jacques Robin Eugene Magennis, Mantovani, G., Alexander, C., Winzer, K., Churchley, D. and Bradshaw, D. Institut Charles Gerhardt - UMR5253 CNRS - Equipe IAM Université Montpellier 2 The University of Nottingham The micellar organization of amphiphilic copolymers in water constitutes a great interest in many fields of application such as drug release, for instance. The reported work deals with the synthesis of poly(vinyl alcohol)-b-poly(vinyl acetate) (PVA-bPVAc) copolymers by combining MADIX polymerization and click chemistry. Both homopolymers were synthesized by MADIX polymerization using new chain transfer agents bearing clickable moieties. PVA-b-PVAc copolymers were finally obtained by Huisgen's reaction using Copper catalysis. Resulting amphiphilic copolymers proved to self-assemble in water. Bacterial Autonemesis Templating Polymers For Cell Sequestration P37 Microwave Mediated Ring-Opening Polymerisdation of Biodegradable Polymers: poly(caprolactone) Edward Greenhalgh, Dr Derek Irvine University of Nottingham Investigation into the effect of mircowave energy on the RingOpening polymerisation of cyclic ester; e-caprolactone. 74 Microwave heating shown to increase rate of reaction. Induction period reduced via faster formation of catalytic species; evidence of superheating of metal centre. Second cyclic ester, D/L-Lactide, introduced to study effect of heating method on copolymer formation. Higher levels of regrowth reported under microwave heating than conventional. P38 Preparation and characterization of a hybrid epoxyacrylic copolymer for high performance coatings application Anabela Carvalho, Veludo, E.b, Machado, J., Coelho, J. F. J. Gil, M. H for the pharmaceutical market. siRNA regulates gene expression by interacting with messenger RNA (mRNA). It can be used to selectively switch off genes. As the human genome is fully sequenced and genome databases are freely available, the mechanism of RNA interference (RNAi) has huge potential in a large number of diseases it could potentially treat. In order to exploit the full potential of siRNA as a therapeutic, delivery vehicles and strategies need to be developed to overcome the current challenges in targeted release of this family of gene therapies. Our current research focuses on the synthesis of a platform of polymers that have potential to complex, stabilise and ultimately deliver siRNA therapies. The technique of controlled radical polymerisation has been employed to generate cationic, well defined polymers with tuneable size and architecture. P41 Chemical Engineering Departement Due to their superior properties, polymeric hybrid materials have been subject of great attention. These materials can be suitable for high performance coatings applications. Epoxyacrylic-silanes are used as protective hybrid coatings, using amines as curing agents presenting good performance. P39 RAFT polymerisation of MMA and Styrene via Supercritical Carbon Dioxide Expanded Phase Simon Bassett, Jianing Li; Jaouad Elharfi, Steven M Howdle, Derek Irvine University of Nottingham Pseudo-bulk polymerisations using supercritical CO2 to expand the reaction mixture has shown both PMMA and PSty powders -1 can be produced at low molecular weight (<10,000 g mol ). High yields were obtained with narrow dispersities achieved via RAFT polymerisation. The lower viscosity of the reaction mixture compared to bulk polymerisations reduces the Trommsdorff effect. Low molecular weight PMMA-b-PSty copolymers have been investigated to illustrate the versatility of the expanded phase technique P40 Engineered platform for siRNA delivery systems Vanessa Locenski, Stephanie Allen, Sebaastian Winkler, Sanyogitta Puri and Giuseppe Mantovani The University of Nottingham Small interfering RNA (siRNA) holds great promise for the development of targeted therapeutics as a treatment paradigm Investigating the Effect of Ionic Liquids on the FRP of MMA Emma Steeds, Jaouad Elharfi, Peter Licence, Derek Irvine University of Nottingham The FRP of MMA in imidazolium based ionic liquids (IL) is investigated and shows changing the IL alkyl chain length impacts on molecular weight. This work shows development of o a two step reaction, where AIBN is heated for 234 h at 80 C, prior to MMA addition. Formation of PMMA provides evidence of an ionic liquid protected radical, and is investigated. The use of CTA, DDM, in these reactions is also explored. This work shows thqat the IL alkyl chain length has an impact on polymerisation of MMA. P42 New protecting groups for the synthesis of polythiols Morgane Le Neindre, Renaud Nicolaÿ and Ilias Iliopoulos ESPCI, Laboratoire Matiere Molle et Chimie Thiol chemistry is one of the most versatile tools for the preparation of functional polymers and materials. In that regards, the use of xanthate, dithiocarbamate and thioacetate moieties as thiol protecting group was investigated. Model reactions were conducted to study the effect of these protecting groups during the controlled radical polymerization of (meth)acrylates and styrenics. The deprotection of these groups by aminolysis was also investigated. Monomers carrying these protecting groups were synthesized and used to prepare various well-defined polythiols. 75 P43 Ricin oil as starting material for the synthesis of renewable semi-crystalline polyesters and poly(esteramide)s Thomas Lebarbé, L. Maisonneuve, B. Gadenne, C. Alfos and H. Cramail University Bordeaux 1- LCPO behavior in aqueous media was studied using different methods, the resulting nanoparticles being analyzed by light scattering and microscopy techniques. P45 The Poly(N-allyl glycine) Platform Joshua Robinson Max Planck Institute of Colloids and Interfaces World-wide potential demands for replacing petroleum-derived raw materials with renewable ones are quite significant from the societal and environmental points of view. One of the solutions proposed to enhance the properties of this type of materials is to increase the number of carbons between two ester functions in order to mimic polyethylene. Another way to achieve this goal is to introduce more cohesive blocks in the polymer structure to yield more robust materials. The selected precursors were synthesized by chemical modification of methyl undecenoate or methyl oleate in a twostep procedure. First a transesterificaton with a diol, or an amidation with a diamine or a combination of both reactions with a hydroxyamine allowed us to design bis-unsaturated diesters, esteramides or diamides, respectively. The second step consisted in the radical addition of thio-ethanol (photo- or thermal- initiation) on the unsaturations leading to various diols. These well-defined diols were reacted with fatty-acid based dimethyl ester in the presence of TBD as a catalyst to prepare polyesters with versatile properties. The so-formed polyesters exhibit enhanced thermo-mechanical properties compared to other bio-based aliphatic polyesters with respect to their melting points, Tg and tensile properties. The structureproperties relationship of the so-formed polyesters will be discussed in the presentation. Standard laboratory bench techniques were utilized in the synthesis of N-allyl glycine N-carboxyanhydride. Ring opening polymerization, under homo- and heterogeneous phase conditions, afforded well-defined polymers with monomodal molecular weight distributions. Short chain polymers were found to be soluble in aqueous medium and exhibited thermoresponsive behavior. High degrees of side chain modifications, with 1-thio-glycerol and thio-glucose, were achieved via photochemical initiated thiol-ene addition. Exceptionally, unprotected thio-glucose could be grafted onto poly(N-allyl glycine) while utilizing environmentally benign conditions. P46 pH responsive nanostructured polymers for the capture and release of bioactive molecules Katherine Sommer, Dr Vitaliy Khutoryanskiy, Professor Howard Colquhoun University of Reading pH responsive nanostructured polymers for the capture and release of bioactive molecules P44 P47 Bioactive self-assembled nanoparticles for cell internalization from polymer-b-peptide chimeras Dye-functionalized fullerenes for application in organic photovoltaics Charlotte Drappier, Olivia Condassamy, Julie Thevenot, Elisabeth Garanger, Sébastien Lecommandoux John Cowart, Chris Liman, Justin Cochran, Fred Wudl, Craig Hawker, Michael Chabinyc Laboratoire de Chimie des Polymères Organiques UMR5629 University of California at Santa Barbara Our project aims at designing polymer-b-peptide chimeras combining a hydrophobic and biodegradable poly(trimethylene carbonate) block and the cell-penetrating TAT peptide also known to facilitate the crossing of the blood-brain barrier. Synthetic strategies developed concern both bioconjugation in solution and solid-phase synthesis. A series of amphiphilic chimeras have been synthesized and their self-assembly In an effort to design fullerenes that enhance light absorption and fullerene/polymer mixing in OPVs, we have developed a series of fullerene-dye adducts. Our approach involves covalently anchoring organic dyes onto fullerene. This promotes an enhanced capacity to harvest visible light, allowing for absorption of photons inaccessible to the polymer alone. These materials are additionally designed to increase thermodynamic 76 control over bulk architectures. The culmination of these features is anticipated to improve power conversion efficiencies in BHJ organic solar cells. P48 Synthesis of Azlactone-functionalized copolymers and their reactivity towards amines Hien The Ho, M.E. Levere, S. Pascual, V. Montembault, L. Fontaine Université du Maine - Institut des Molécules et Matériaux du Mans - UCNRS 6283 Strategies and recent developments used to prepare aminereactive polymers based on the azlactone functionality using controlled radical polymerisation (ATRP and RAFT) and thiolMichael addition “click” reaction are summarized. The ability of these well-defined polymers to react with amines is studied under mild conditions without the formation of by-products. Such reactivity makes them promising candidates for bioconjugation methodologies. P49 Acrylic based emulsions as enhancers of geopolymer properties. Inês Barata, M.H. Gil, Jorge Coelho University of Coimbra - Chemical Engineering Department Geopolymer is a synthetic aluminosilicate material that can be used as a replacement for Portland cement. In order to give enhanced properties (resistance and workability) to geopolymer based facade panels, acrylic emulsions can be incorporated in the formulation. In this work, different acrylic emulsions were developed and characterized. The type of monomer, surfactant and addition method was varied and the influence of these parameters in the particle size, morphology and thermal behavior of the emulsions were evaluated. P50 Improving Polymer Solar Cells with Multifunctional Conjugated Polymers Maxwell Robb, Nancy Eisenmenger, Nathaniel A. Lynd, Kris T. Delaney, Michael L. Chabinyc, Craig J. Hawker University of California The ability to control the properties at the interface of donor and acceptor components in bulk heterojunction organic photovoltaic devices is a paramount goal. We have recently developed a synthetic strategy that enables the preparation of well-defined, p-type low-band-gap polymers containing n-type functional moieties. These multifunctional polymers represent a new class of additives designed to enhance a variety of fundamental properties in the active layer of bulk heterojunction devices. The synthesis and characterization of these novel additives will be discussed along with their influence on charge transport, morphology, and absorption in polymer solar cells. P51 Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery Qiuming Liu Tianbin Ren, Hang Lu, Hongmei Liu, Xin Zhang and Jianzhong Du Tongji University A new class of block copolymer, PEO-b-P(AA-stat-tBA) can selfassemble into polymer vesicles with tuneable sizes at various conditions. The superparamagnetic iron oxide nanoparticle (SPION) was in situ generated within the membrane of the polymer vesicles by nanoprecipitation. Those water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T2 relaxivity, demonstrating ultra-sensitivity for imaging and promising potential applications in nanomedicine. P52 Hydrogels formed by Glycopolymers via dynamic covalent bond with multiple sensitivities lu su Fudan University A novel dual-responsive supramolecular hydrogel composed of two block copolymers poly(acrylamidophenylboronic acid)block-poly(N-isopropylacrylamide) (PAAPBA-b-PNIPAM) and poly(acrylamidogalactose)-block-poly(N-isopropylacrylamide) (PAAGal-b-PNIPAM) have been demonstrated. Based on the dynamic covalent bond between phenylboronic acid and galactose, the two block copolymers form a complex in basic aqueous solution, which is proved by the Dynamic Light Scattering (DLS) and Transmission Electron Microscope (TEM). Hydrogel forms easily upon heating at a concentration of the complex (8wt %) as a result of PNIPAM aggregation occurred above its LCST. The dynamic covalent bond and the domains of the collapsed PNIPAM chains serve as two distinct cross-links 77 and render the hydrogel excellent dual sensitivity to pH and to temperature variations. P53 Rapid and reversible micelle-to-vesicle transition induced by temperature and its further application in self-assembly of nanoparticles Kongchang Wei, Lu Su, Jun Li, Jianghua Liu, Guosong Chen, Ming Jiang Department of Macromolecular Science, Fudan University As a key feature of supramolecular chemistry, reversibility of self-assembly procedures is also important for fabrication of smart materials. Poly(N-isopropyl acrylamide) (PNIPAM) may be the most popular thermo-responsive polymer with the wellknown coil-to-globule transition at the lower critical solution temperature (LCST).Profiting from this property, we studied selfassembly of polymeric and inorganic nanoparticles embedded with PNIPAM and it was found that nanoparticles can selfassembled into vesicles above LCST of PNIPAM, which could disassemble into nanoparticles reversibly below LCST. This morphology transition was shown robust and applicable for other nanoparticles. P54 All-Acrylic Film-Forming Colloidal Polymer/Silica Nanocomposite Particles Prepared by Aqueous Emulsion Copolymerisation The University of Sheffield A glycerol-modified 19 nm aqueous silica sol and cationic azo initiator are used to synthesise poly(methyl methacrylate-co-nbutyl acrylate)/silica nanocomposite particles. Parameters such as the initial silica sol concentration and comonomer ratio are systematically varied to optimise the colloidal stability and glass transition temperature. Particle morphologies are analysed by electron microscopy and SAXS and optical and mechanical properties of nanocomposite films are assessed. P55 David Growney and S.P. Armes University Of Sheffield P56 Efficient Synthesis of Amine-functional Diblock Copolymer Nanoparticles via RAFT Dispersion Polymerization of Benzyl Methacrylate in Alcoholic Media Elizabeth Jones, M. Semsarilar, A. Blanazs, S. P. Armes University Of Sheffield Benzyl methacrylate is polymerized via RAFT chemistry under alcoholic dispersion conditions in ethanol using a poly(2(dimethylamino)ethyl methacrylate) chain transfer agent (CTA) at ;C. A detailed phase diagram was constructed using a PDMA31 macro-CTA by systematically varying both the target DP of the PBzMA block and the total solids concentration of the reaction solution. These PDMA-PBzMA nanoparticles remain colloidally stable when transferred from ethanol into water; aqueous electrophoresis studies confirmed that the particles acquire appreciable cationic character below pH 7 due to protonation of the PDMA chains P57 The Development of Easily Processable Polymer Hydrogels for Biomedical Applications Lee Fielding and Steven P. Armes Effect of temperature on the micellisation of polystyrene-based block copolymers in n-alkanes A near-monodisperse polystyrene-based diblock copolymer prepared via anionic polymerisation forms well-defined polystyrene-core micelles in n-alkanes. The effect of varying the solution temperature from 20oC to 90oC on the micelle dimensions is studied using transmission electron microscopy, dynamic light scattering, 1H Nspectroscopy and small angle x-ray scattering. Victoria Boyes, Chris Sammon*, Subodh Sabnis*, Christine Le Maitre+ Becky Barthrop+ and Jonathan Foulkes *Materials and Engineering Research Institute, Sheffield Hallam University, Howard St, Sheffield, S1 1WB, UK Hydrogels are a class of polymer materials with three dimensional cross-linked hydrophilic network structures which contain and absorb large amounts of water. Human mesenchymal stem cells (MSCs) were labelled with a green fluorescent membrane dye to enable visualisation prior to culture within or on hydrogel systems. Our novel pNIPAM materials exhibit some excellent properties. They have the capacity to be processed routinely using a range of common processing approaches. Our initial biocompatibility studies have shown that MSCs readily proliferate and produce matrix in the presence of the hydrogels and, more importantly, MSCs can be 78 mixed with the hydrogel precursor and injected into a cadaver without any detriment to the cells’ ability to proliferate. Rosemeyre Cordeiro, Nuno Rocha, Arménio C Serra and JFJ Coelho Chemical Engineering Department - University of Coimbra P58 Kinetic Studies of pH-Responsive Latexes: How Fast is the Latex-to-Microgel Transition? Andrew Morse, Damien Dupin and Steven P. Armes The University of Sheffield Lightly cross-linked sterically-stabilised poly[2-vinylpyridine], poly[2-diisopropylamino ethyl methacrylate] and poly[2diethylaminoethyl methacrylate] pH-responsive latexes were prepared via emulsion copolymerisation. In each case the latexto-microgel transition occurred at around the respective pKa of the latex. The kinetics of swelling during a pH jump was studied using a stopped-flow set-up. The rate of swelling was found to be strongly dependent on the copolymer structure. P59 Characterisation of biomimetic materials using dynamic mechanical analysis Dr Kerstin Mader, T. Smallwood, C. Le Maitre, C. Sammon Sheffield Hallam Universtiy Low back pain affects a large portion of the world's population and is a major cause of disability worldwide. Although, IVDs basically consist of only two phases, namely a protein phase and a polysaccharide phase, their structural organisation is complex. The mechanical behaviour of an IVD is heterogeneous and depends on multiple factors such as the protein to polysaccharide ratio and the confirmation and orientation of the individual components. Due to this unique organisation of collagen fibers embedded in hydrated proteoglycan gels IVDs can withstand high mechanical stresses. In order to develop suitable biomimetic gels a thorough characterisation profile that can be used as an aspirational target is essential. In this study we investigate the mechanical properties of native and synthetic material using dynamic mechanical analysis (DMA), showing how by tailoring the structure and composition of these materials we can modify the intrinsic mechanical properties. P60 Synthesis of poly(2-dimethylamino)ethyl methacrylate) by Atom Transfer Radical Polymerization (ATRP) using a mixture of metal catalysts In this work, zero-valent iron Fe(0)) and copper bromide (CuBr2) were used as catalysts for atom transfer radical polymerization (ATRP) of 2-(dimethylamino)ethyl methacrylate using alcohol/water mixtures at ambient temperature. Nuclear magnetic resonance and gel permeation chromatography results confirmed a good conversion and a narrow molecular weight distribution. The results suggest that this system is easier, cheaper and environmental friendly than classical ATRP processes. P61 Hydration properties of synthetic nucleus pulposus candidates Thomas Smallwood and K. Mader, C. Sammon Sheffield Hallam University, Materials and Engineering Research Institute Low back pain affects a large portion of the world's population and is a major cause of disability worldwide. In many cases low back pain has been linked to degenerative changes in the intervertebral disc (IVD). IVDs can be described as having a biphasic construct, the two regions consisting of the softer inner core termed the nucleus pulposus (NP) and the fibrous outer the Annulus Fibrosus (AF). The NPmimetic project aims to develop a minimally invasive therapy to reconstruct and regenerate diseased IVDs in situ by developing gel configurations to mimic native IVD via in vivo and ex vivo studies as well as computational modelling. In addition to this, the scaffold can be further functionalised with anti-inflammatory drugs with a view to a controlled release over time via the biodegradation of the scaffold, providing a pathway to short-term, localised pain relief. P62 Synthesis and Characterization of Novel Polyacid Stabilized Latexes Pengcheng Yang and S. P. Armes Department of Chemistry Macromonomers are polymers that contain at least one polymerizable group that is often located at the chain end. Here we report the synthesis and characterization of a novel polyacid 79 macromonomer based on 2-hydroxypropyl methacrylate (HPMA) prepared by atom transfer radical polymerization (ATRP) via a two-step route. In the first step, a range of welldefined PHPMA homopolymer precursors were synthesized by ATRP using a 2-(dimethylamino)ethyl-2-bromoisobutyrylamide initiator and a Cu(I)Cl/2, 2’-bipyridine (bpy) catalyst in alcoholic media at 50 oC. In the second step, these PHPMA homopolymer precursors were derivatized to produce the corresponding poly(2-(succinyloxy)propyl methacrylate) (PSPMA) macromonomers by complete quaternization of the tertiary amine end-group with 4-vinylbenzyl chloride, followed by esterification of the pendent hydroxyl groups using excess succinic anhydride at 20 oC. These polyacid macromonomers were evaluated as reactive steric stabilizers for the synthesis of polystyrene latex under either aqueous emulsion polymerization or alcoholic dispersion polymerization conditions. P65 Polypyrrole-coated Silica Particles Joseph Lovett, Lee A. Fielding and Steven P. Armes The University of Sheffield Polypyrrole is an organic conducting polymer that can be deposited from aqueous solution onto polystyrene latex. We have extended our earlier studies in order to deposit polypyrrole onto more hydrophilic inorganic oxide particles such as silica. The resulting core-shell silica-polypyrrole particles are characterised in terms of their size distributions, degree of dispersion, polypyrrole contents and surface morphologies. Potential applications for these composite particles are suggested. P63 Sterically-Stabilized Polypyrrole Nanoparticles As Optical Contrast Agent for High Resolution Optical Coherence Tomography Imaging Kin Man Au, Zeng H. Lu,Steven J. Matcher,Steven P. Armes P66 Antibacterial Copolymer Hydrogels Amanda Harvey, Steven P. Armes, C. W. Ian Douglas and Sheila MacNeil University of Sheffield Department of Chemistry, The University of Sheffield Optical coherence tomography (OCT) is a non-invasive optical imaging technique that can be used to diagnose epithelial cancer. However, despite its high resolution, multiple scattering in human tissue often reduces OCT performance. Herein we use sterically-stabilised polypyrrole nanoparticles as a near-infrared absorbing contrast agent for high resolution OCT imaging. The synthesis of these nanoparticles and a preliminary investigation of their in vitro and in vivo performance will be reported. P64 Clay-based Colloidosomes Mark Williams, Steven P. Armes and David W. York The University of Sheffield Poly(ethylene imine) (PEI) is electrostatically adsorbed onto Laponite clay nanoparticles, which are then used to produce oilin-water Pickering emulsions with a range of model oils. Crosslinking is confined within the oil droplets using an oil-soluble polymeric bis-epoxide to produce clay-based colloidosomes. These colloidosomes are sized using laser diffraction and are sufficiently robust to survive removal of the internal oil phase, as judged by optical and fluorescence microscopy. As copolymers have potential biomedical applications, the aim of the current study was to study the relationship between copolymer composition and architecture so as to elucidate their likely antibacterial mechanism. More specifically, the antibacterial activity of various different monomers/copolymers of poly(2-(methacryloyloxy) ethylphosphorylcholine) [PMPC], poly(2-hydroxypropyl methacrylate) [PHPMA] and poly(glycerol monomethacrylate [PGMA] towards Staphylococcus aureus will be examined. PHPMA homopolymer brushes were investigated by growing PHPMA chains from ATRP initiator-coated surfaces, brush thicknesses were characterized via ellipsometry, and antibacterial activity assessed via direct contact. Block copolymers were synthesized using either ATRP or RAFT polymerization and characterized via 1H NMR, GPC and rheology. Anti-bacterial activity was assessed using several wellknown assays, including direct contact, adhesion, minimum inhibitory concentration [MIC] and minimal bactericidal concentration [MBC]. We have also prepared fluorescentlylabeled copolymers using a rhodamine 6G-based ATRP initiator to view their interactions with cells and bacteria. The combination of antimicrobial activity with mammalian cell biocompatibility is unusual and suggests potential biomedical applications for these materials. P67 80 literature reports, very high conversions (92 to 100 %) are obtained within 24 h, as judged by 1H Nspectroscopy. Thus this new formulation for producing bespoke organic nanoparticles is potentially scalable and is expected to have a range of commercial applications. The synthesis of PGMA-b-PHPMA block copolymers using ‘one-pot’ aqueous dispersion polymerisation Liam Ratcliffe and S.P. Armes University Of Sheffield Previous work has shown that glycerol monomethacrylate (PGMA) can be block copolymerised with 2-hydroxypropyl methacrylate (PHPMA) under aqueous dispersion conditions to yield spherical, worm-like and vesicular morphologies.The present work shows that the significantly cheaper commercially available monomer glycidyl methacrylate (GDMA) can be efficiently utilised as a precursor to GMA, thus allowing an entirely ‘one-pot’ synthesis to the aforementioned self assembled structures. P68 The Effect of Varying Hydrophobic Block Lengths on the Microstructure of Vesicles Prepared by Aqueous RAFT Dispersion Polymerisation Dr Nicholas Warren and S. P. Armes Department of Chemistry RAFT aqueous dispersion polymerisation of hydroxypropyl methacrylate (HPMA) using a poly(glycerol monomethacrylate)55 macro chain transfer agent can be used to prepare various nano-objects in-situ such as spherical micelles, wormlike micelles and vesicles. In particular, vesicles can be prepared at 10 wt % by targeting PHPMA DP of > 300. The aim of this study is to assess the effect of increasing the PHPMA degree of polymerisation (DP) to ~2000 on both the copolymer and the vesicle architecture. In particular, we shall attempt to use small angle x-ray scattering to determine the variation in wall thickness at these high DPs. P69 Efficient Synthesis of Sterically-Stabilized Nano-Objects via RAFT Dispersion Polymerization of Benzyl Methacrylate in Alcoholic Media Mona Semsarilar and S.P. Armes University Of Sheffield RAFT dispersion polymerization of benzyl methacrylate in alcohol at 64-70oC using either non-ionic, zwitterionic, polyacid or polybase macromolecular chain transfer agents affords low polydispersity diblock copolymers with well-defined morphologies (e.g. spheres, worms or vesicles). Unlike previous P70 Polysaccharide-Assisted Clustering of Metal Nanoparticles within Colloids Dr Ekaterina Gasilova, Galina Matveeva, Natalia Shevchenko, Galina Aleksandrova, Boris Sukhov, Boris Trofimov Institute of Macromolecular Compounds, Russian Academy of Sciences Metal nanoparticles (NP) functionalized by biomacromolecules are used in a rapidly emerging field of nanobiotechnology. Several polysaccharides have been reported to serve both as nanoreactors reducing metal ions and stabilizing agents in the green colloidal NP synthesis. In particular, NP of various noble metals were obtained by using arabinogalactan (ARB) extracted from Larix Sibirica. Localized surface plasmon resonance of coupled NP within clusters make coupled NP the most efficient scatterers. This effect is interesting for biosensing. DNA- or protein-based recognition elements were used for templating the spatial assembly of NP on a substrate. In order to form the NP clusters within colloids, a capping agent must both allow primary NP to form initial clusters and prevent these clusters from further aggregation. We used scattered light depolarization as an indication of the overall form of NP clusters. Thus, nonzero depolarization of light scattered from the ARB-NP(Au) colloids was attributed to the formation of the NP(Au) dimers. Absence of the scattered light depolarization in the ARB-NP(Pd) colloids indicated a spherically symmetric distribution of Pd nanoparticles within the colloidal aggregate. These findings are in accord with the TEM images of the NP(Au) and NP(Pd) clusters in dried nanocomposites. Enhanced scattering from coupled NP makes dynamic light scattering extremely sensitive to the size of colloids containing the largest NP clusters. P71 Membranes from an unsaturated poly(ester amide) based on glycine and (L)-lactic acid and poly(ethylene glycol): Preparation , Characterization and Biodegradation Studies Ana Fonseca Maria H. Gila and Pedro N. Simõesa Chemical Engineering Department, University of Coimbra 81 Poly(ester amide)s (PEAs) based on -amino acids and -hydroxy acids are a class of polymers with interesting properties for application in biomedical field and whose importance has increased in the last years. In this work, an unsaturated PEA based on glycine and L-lactic acid was synthesized for the first time and used in photopolymerization reactions to form membranes. The swelling capacity, morphology and biodegradation behavior of the membranes were evaluated. The results showed that the properties of the membrane can be tuned by the content of PEA. P72 A Comparison between Grafting from and Grafting to Cellulose via ARGET ATRP Susanne Hansson Thomas Tischer, Anja S. Goldmann, Anna Carlmark, Christopher Barner-Kowollik, and Eva Malmström P74 Fluoro-Containing Nanoparticles as Theranostic Delivery Systems Christian Porsch Yuning Zhang, Andreas Nystrom, Eva Malmstrom KTH Royal Institute of Technology In the present work we employ ARGET ATRP as a synthetic tool to make polymer nanoparticles which function as theranostic delivery systems. Incorporation of fluorinated segments into the polymeric materials provide high resolution traceability of the nanocarriers by 19F-MRI, and offer the possibility to encapsulate therapeutic doxorubicin into the nanoparticle interior. Architectural influence on the theranostic function, therapeutic release, and nanoparticle size and shape is further examined. P75 KTH Royal Institute of Technology Cellulose is a very attractive material owing to its native properties such as biocompatibility, renewability, and good mechanical properties, all combined with a low price. However, it is often necessary to modify cellulose to expand its applicability, e.g. by employing ATRP. In this study, a comparison is made between the grafting to and the grafting from method, two grafting approaches commonly applied when modifying cellulose surfaces. Furthermore, high-resolution FT-IR microscopy (FT-IRM) imaging is employed to visualize the polymer distribution on the cellulose fibers. P73 Dendronized Surfaces for Probing Multivalent Cell Interactions Kim Oberg, Jarmo Ropponen, Anders Lundgren, Mattias Berglin, Michael Malkoch A comparative study of covalent grafting and physical adsorption of PCL onto cellulose Carl Bruce Simon Utsel, Emma Larsson, Linda Fogelström, Lars Wågberg and Eva Malmström KTH Royal Institute of Technology In this study, a comparison between covalent grafting and physical adsorption of PCL onto a nanocellulose model surface was conducted. For the covalent attachment, surface-initiated ring-opening polymerization (SI-ROP) was performed. For the physical attachment, a charged block copolymer consisting of PCL and quaternized PDMAEMA was synthesized by ROP and ATRP, and adsorbed to the cellulose. Finally, differences in between the two substrates were investigated with techniques such as AFM. KTH Royal Institute of Technology Dendronized surfaces were generated by chemisorption of a library of bis-MPA based dendrons generations G1-G3 with varying organosulfur cores and peripheral end-groups (hydroxyl and mannose). Specific focus was devoted to investigating dendron structural factors affecting the spontaneous selfassembly into monolayers. Furthermore, these surfaces were evaluated for bacterial scavenging of uropathogenic E. coli bacteria revealing a higher scavenging capacity of higher generation mannose surfaces. P76 Surface-Initiated Ring-Opening Metathesis Polymerization from Cellulose Fibers Linn Carlsson, Eva Malmström and Anna Carlmark* KTH Royal Institute of Technology, Fibre and Polymer Technology In this work, surface-initiated ring-opening metathesis polymerization (SI-ROMP) of norbornene has been performed from cellulose fibres. Prior to polymerization, hydroxyl groups on the cellulose were immobilized with a Grubbs type catalyst. The grafting was performed at different temperatures; room 82 temperature, 0 °C and -18 °C, and different reaction times; from 1 minute up to 1 hour, respectively. The successful grafting was confirmed by CA measurements, FT-Raman, TGA and FE-SEM. P77 Functional Polymer Nanocomposite for High-Voltage Insultation tert-butyl vinylbenzoate) was tested in sequence-controlled radical copolymerizations in the presence of acceptor comonomers (i.e., N-substituted maleimides). The copolymers were synthesized by nitroxide mediated polymerization using the alkoxyamine BlocBuilder MA. The copolymers obtained showed low polydispersities, controlled molecular weights and controlled monomer sequences. Some of these sequencecontrolled polymers were hydrolyzed into neutral or ionic watersoluble macromolecules. Martin Wåhlander, Anna Carlmark Malkoch P80 Eva Malmström Jonsson Synthesis of sequence-defined segments using tailormade soluble polymer supports. KTH Royal Institute of Technology Properties of nanocomposites, containing inorganic particles, can be significantly affected by particle content, size, dispersability and surface chemistry. In this study, nanoparticles (NP) of Al-oxide are grafted with different chain lengths of PBA by SI-ATRP. The properties and behaviours of the NPs are evaluated with and without a polymeric matrix. Their selfassembly and spontaneous arrangement within a matrix of EBA is of special interest both for the mechanical and electrical properties. P78 Lithium-Ion Conducting Thermoset Electrolytes for Multifunctional Applications Anna Meszynska, J-F. Lutz Institute Charles Cadron This presentation will highlight a method to obtain block copolymers containing sequence-defined segments by usage of soluble polymer supports prepared by ATRP. Well-defined cleavable or non-cleavable soluble polystyrene supports allowed synthesis of peptide-polymer conjugates in a rapid and efficient way. Moreover, the strategy is not limited to bio-hybrid polymeric architectures but can be extended to a wide variety of other synthetic segments. P81 Markus Willgert, Mats Johansson Novel Phthalocyanine and PEG-methacrylates based Temperature-responsive Polymers for Targeted Photodynamic Therapy KTH Royal Institute of Technology The present study is on multifunctional battery electrolytes, where a polymer electrolyte is designed to fulfill two tasks; lithium ion transport and mechanical load carriage. The purpose is to replace load carrying units within the construction of a portable electric device with an actual battery. This is done in order to minimize the parasitic nature of a battery in terms of weight and space. In this project, methacrylated poly(ethylene oxide) as well as thiol compounds are utilized. P79 Synthesis of sequence-controlled water-soluble polymers via copolymerization of donor and acceptor comonomers. Sansanee Srichan Delphine Chan-Seng and Jean-François Lutz Institut charles sadron Jun Li , Weidong Zhang and Gaojian Chen Soochow University A novel multi-targeting nanocarriers for Photodynamic Therapy has been successfully synthesized via the incorporation of SiPcCl2 with PEGMEMA polymers. The synthesized polymers present high singlet oxygen quantum yields upon light irradiation. They assemble into nanoparticles (70 nm) in aqueous solution, with thermo-responsive feature that provides possibility to selectively accumulate at a maligned tissue site upon mild heating. This provides a simple way to synthesize multi-targeting drug carrier system for PDT. P82 Ambient Temperature Rapid ATRP of MA in DMSO with Mixed Transition Metal Catalyst System A series of para-substituted styrene derivatives (i.e., 4methylstyrene, 4-acetoxystyrene, 4-tert-butoxystyrene, and 4- 83 Patrícia Mendonça Arménio C. Serra, Jorge F. J. Coelho, Anatoliy V. Popov, and Tamaz Guliashvili the synthesis of alpha-end-functionalized polymers via one-pot polymerization/alcohol-isocyanate coupling. Department of Chemical Engineering of the University of Coimbra P85 Room temperature atom transfer radical polymerization of methyl acrylate, methyl methacrylate and styrene in the presence of several polar solvents, using a mixed transition metal catalyst system provides a rapid synthesis of polymers with very low polydispersity values and predetermined molecular weights. The catalytic system is based on Fe(0) as initial activator and CuBr2/Me6TREN complex as deactivator. The polymethylacrylate prepared using this novel approach contains high -Br chain-end functionality and can be effectively used for block copolymer synthesis. P83 Reduction-Sensitive Shell-Sheddable Biodegradable Micelles for Intracellular Doxorubicin Delivery Anti-HIV peptide-polymer therapeutics Dr Maarten Danial Maarten Danial, Andy Pötgens, Angela Stauffer, Michael J. Root, Harm-Anton Klok University of Sydney HIV-1 is a pandemic and although 25 different drugs are available, not one offers a cure. One recent addition to anti-HIV1 therapy is the peptide drug T-20, which works by blocking the initial stages of HIV-1 entry into the cell by acting as a membrane fusion inhibitor. Despite its high potency, however, T-20 mainly suffers from low plasma half-life, which is caused by several processes including proteolytic degradation. Through site-specific polymer conjugation to peptides like T-20, we have made novel, biocompatible and effective HIV-1 inhibitors that have enhanced resistance towards proteolysis. Huanli Sun Wei Wang, Fenghua Meng, Ru Cheng, Chao Deng, Zhiyuan Zhong* Soochow University Reduction-sensitive nano-carriers have recently received a tremendous amount of interest for intracellular drug release. In the past couple of years, we have developed novel reductionsensitive shell-sheddable biodegradable micelles based on PEGSS-PCL and Dextran-SS-PCL copolymers for efficient intracellular release of doxorubicin (DOX). Notably, our results have shown that intracellular drug release and anti-tumor activity of DOXloaded PEG-PCL micelles can be precisely controlled by the extent of shell-shedding. P84 In situ generation of isocyanate during the RAFT process. Easy access to alpha-end functionalized polymers in a one-pot fashion. P86 Synthesis and Applications of Functional Nanoparticles via Living Radical Polymerization John Moraes Sebastien Perrier, Kohji Ohno, Yun Huang, Thomas Maschmeyer Key Centre for Polymers and Colloids Hybrid nanoparticles hold great promise for a range of applications such as drug-delivery vectors or colloidal crystals self-assemblies. The challenge of preparing highly monodisperse particles for these applications has recently been overcome by using living radical polymerization techniques. We herein present the preparation and modification of such particles with a variety of functionalities via solid-supported RAFT polymerization. The use of RAFT also allows us to effect postpolymerization modification to afford multifunctional, monodisperse, nano-assemblies. Dr Guillaume Gody, Thomas Maschmeyer, Sebastien Perrier1 P87 Key Centre for Polymers & Colloids Amongst the most used ‘click’ reactions (azide-alkyne, thiolene/yne), the fast and complete addition of nucleophiles (alcohols, thiols and amines) to an isocyanate group appears promising. A new method for the preparation of alpha-endisocyanate polymers is reported. Our novel synthetic strategy is based on the preparation of a carbonyl-azide RAFT agent precursor that re-arranges into an isocyanate in-situ during the RAFT process. The versatility of this method can be applied to Creating Functional Hyperbranched Polymers by a Combination of RAFT Polymerization and Thiol–Yne Reactions Dr Raphael Barbey and Sébastien Perrier Key Centre for Polymers & Colloids - University of Sydney 84 Our group recently developed a strategy for the preparation of hyperbranched polymers based on the UV irradiation of (macro)molecules bearing a thiol moiety at one end and an alkyne group at the other in the presence of trace amount of photoinitiator. Such molecules act as an AB2 monomer where the thiol is the A unit and each of the bond of the alkyne is the B unit. Here we will discuss conditions for the synthesis of these hyperbranched polymers and we will present strategies for their subsequent functionalization. P88 molar ratios showed a decreasing level of control as the SDPP molar fraction (fSDPP) increased, with a satisfactory level of control being achieved for fSDPP = 0.25 (constant concentration of growing “living chains”, linear Mn growth with conversion and low dispersity). Copper-free polymers with different chain lengths were prepared and tested as polymeric ligands in the Rh-catalyzed hydroformylation of 1-octene. The polymeric ligands yielded higher linear/branched selectivity and lower activity relative to PPh3 at the same P/Rh ratio. The selectivity increased slightly as a function of the polymer chain length. P90 N-Heterocyclic-catalyzed synthesis of polyurethanes Dr olivier coutelier Olivier Coutelier, Mohammad El Ezzi, Mathias Destarac, Fabien Bonnette, Tsuyoshi Kato, Antoine Baceiredo, Gopakumar Sivasankarapillai, Yves Gnanou and Daniel Taton Université Paul Sabatier N-heterocyclic carbenes (NHCs) have recently emerged as an outstanding class of organocatalysts that can be used in a broad range of organic reactions. Over the past decade, an increasing number of polymerization systems catalyzed by NHCs have been developed. However, to our knowledge, just a few publications report the use of masked carbene as catalysts for the synthesis of crosslinked polyurethanes. In this communication, we will discuss the role played by a free NHC catalyst during the urethane bond formation and its application for the synthesis of various linear polyurethanes. P89 Antibacterial polymer brushes Shoghik Hakobyan Olena Rzhepishevska, Madeleine Ramstedt Umeå University The aim of the project presented is development of antibacterial surfaces using polymeric films functionalized with e.g. gallium hydrazone complexes. Polymer brushes are prepared using surface-initiated polymerization using atom transfer radical polymerization (ATRP). The thickness of the brush films is generally less than 1 µm. Reference experiments showed a decreased attachment of bacteria to poly anionic brushes, as well as to protein repellent brushes. On poly cationic brushes, an increased attachment as well as apparent influence on bacterial cell processes was observed. P91 TBC Ying Li New polymer-supported phosphine ligands: ATRP synthesis and catalytic performance Dr Florence Gayet Andrés F. Cardozo, Eric Manoury, Carine Julcour, Jean-François Blanco, Henri Delmas, Florence Gayet, Rinaldo Poli University of Illinois, Urbana and Champaign TBC P92 RAFT polymerization of methacrylic acid in water Laboratoire de Chimie de Coordination Owing to the high price of rhodium and to avoid subsequent purification steps of the products, supported or immobilised phosphine ligands for catalysts recovery and recycling is a subject of interest in catalytic hydroformylation process design. In this work, a series of polystyrene supported tertiary phosphine ligands were prepared by copper catalyzed atom transfer radical polymerization (ATRP), involving direct copolymerization of styrene and styryldiphenylphosphine (SDPP). Copolymerization of the two monomers at different Isabelle Chaduc Muriel Lansalot, Franck D'Agosto, Bernadette Charleux CNRS - C2P2 RAFT polymerization of methacrylic acid was successfully performed in water in the presence of a trithiocarbonate, the 4cyano-4-thiothiopropylsulfanyl pentanoic acid, as a RAFT agent. Several parameters such as the temperature, the concentration, the pH, the targeted polymerization degree and the initiator concentration were studied. For pH value below the pKa of 85 MAA, well-defined PMAA chains with different molar mass up to 92 000 g.mol-1 exhibiting low dispersty (Ð < 1.19) were obtained under a broad range of synthetic conditions. be further processed into nanostructured film materials whose physical properties could strongly benefit from the spatial organization of the anisotropic filler. P93 P96 TBC Enhanced Spin Capturing in Polymerization of Ethylene Joana Rita Góis Cedric Dommanget, Christophe Boisson, Franck d’Agosto, Vincent Monteil, Bernadette Charleux, Department of Chemical Engineering of the University of Coimbra Fernande Boisson, Thomas Junkers, Christopher BarnerKowollik, Didier Gigmes TBC P94 Efficient metal-mediated surface-initiated polymerization from raw polymer latex in water. Virginie Chabrol, Didier Léonard, Matthias Zorn, Bernd Reck, Franck D’Agosto, Bernadette Charleux C2P2-LCPP The incorporation of a hydrophilic polymer shell at the surface of latex particles was studied using a grafting from approach based on aqueous copper-mediated radical polymerization. Latexes were synthesized via classical emulsion polymerization and functionalized at their surface with a Br-functional group which played the role of the initiator in the grafting reaction. Conditions under which the grafting could be performed at 25°C, using a real latex (no elimination of the surfactant and of the radical initiator), in the presence of Cu0, CuBr2 and PMDETA were identified. Laboratoire de Chimie, Catalyse, Polymères et Procédés (C2P2) Equipe Chimie et Procédés de Polymérisation (LCPP) The efficiency of enhanced spin capturing polymerization (ESCP) to control molecular weight distributions in ethylene under mild conditions (200 bar, 70°C) has been established for the first time. Midchain alkoxyamine functional polyethylenes were produced. The precise polymers microstructure was fully characterized using Nspectroscopy (1H, 13C, COSY, HSQC). We also take advantage of ESCP to synthesized ABA-type blockcopolymers of ethylene and styrene. P97 TBC Dr Ian Barker The University of Warwick TBC P98 P95 Synthesis of anisotropic polymer-decorated Imogolitelike nanotubes by RAFT-mediated emulsion polymerization Ana Maria Cenacchi Pereira, M. Lansalot, F. D’Agosto, A. M. dos Santos, A. Thill, E. Bourgeat-Lami CPE Lyon - Laboratoire de Chimie, Catalyse, Polymères et Procédés (C2P2) - LCPP group We report the elaboration of anisotropic aluminogermanate (Imogolite)/polymer colloidal nanocomposites by RAFTmediated emulsion polymerization. Hydrophilic macroRAFT copolymers were synthesized and adsorbed on the surface of Imogolite nanotubes. These macroRAFT agents were used to initiate the growth of a hydrophobic monomer forming polymer nodules on the surface. The resulting anisotropic particles can Amphiphilic linear-dendritic block copolymer containing azobenzene and PEG: Self assembly and photoresponse Eva Blasco Milagros Piñol, Luis Oriol. Universidad de Zaragoza-CSIC Amphiphilic block copolymers have been attracting much attention due to the variety of potential applications such as controlled drug delivery, nanoreactors, biomimetics. Firstly, we have studied the self-assembly of this block copolymer in water. The critical aggregate concentration was calculated by using Nile Red, a fluorescence probe. Morphology of the polymeric selfassemblies was checked by TEM and cryo-TEM revealing the presence of vesicles. Size of the aggregates was also evaluated by DLS. The mean hydrodynamic diameter was found to be around 350 nm. 86 In order to study the photoresponsive behaviour, polymeric aggregates solution was irradiated with UV light (365nm). It is described that when some aggregates solutions are irradiated with UV light, trans-to-cis isomerisation takes places producing a change in shape and polarity in azobenzene moieties allowing modification or even disruption of the aggregates. In conclusion, we have synthesized a new amphiphilic linear dendritic block copolymers able to form light-responsive vesicles in water. Fluorescence probes achieve proving that aggregates can be used as a controlled delivery system. P99 Synthesis, Characterization and Tribological Implications of End-Grafted Poly(acrylamide) Films in WaterMethanol Mixtures Professor George Simon Marini Sawawi (Monash) and David Nisbet (ANU, Canberra, ACT, Australia) Monash University In this presentation we report on a new method for producing short, chopped nanofibres from a non-woven electrospun polymer mesh. Such short fibres are ideal for drug release, tissue engineering or for inclusion in all-polymer nanocomposites where increased modulus and toughness is desired. We will show the effect of polymer type, fibre orientation and fibre thickness, along with other processing conditions (including post-processing of the fibres) on the final morphology of the fibres, in particular the final short fibre length. P101 Ang Li Shivaprakash N. Ramakrishna, E. S. Kooij, Rosa M. Espinosa-Marzal, Nicholas D. Spencer New Supramolecular Approaches For Chemotherapeutic Treatments Incorporating Both Remote And Local Controls Handles Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich Dr Xian Jun Loh In this study, thin films of poly(acrylamide) (PAAm) brushes and hydrogels with various crosslinking degrees were fabricated from iniferter-functionalized silicon substrates by UVLEDinitiated photopolymerization and their properties were further studied by means of a variety of analytical methods.The nanotribological properties of surface tethered PAAm films with various crosslinking degrees were also investigated in aqueous methanol mixtures by using colloidal probe atomic force microscopy. Swelling behaviors of these chemically identical films were tuned by means of varying crosslinking degree and composition of the mixture of water (good solvent for PAAm) and methanol (bad solvent for PAAm), i.e. the solvent quality. Crosslinking degree and solvent quality-dependent adhesive features of PAAm films were unveiled by examining their pull-off forces. Furthermore, a series of parameters influencing adhesive properties of films with brush structures at the glass transition – contact area, testing speed and solvent quality – were investigated. By exploring the frictional properties of PAAm films at nanoscale, PAAm films appeared complex tribological behaviors due to the interplay between crosslinking degree, solvent quality and adhesion force. These fundamental insights are of great practical importance for the design of polymer coating with tunable lubricating/adhesion characteristics for applications in aqueous lubrication and stabilization of colloidal particles, amongst others. P100 Ultrasonication as a New Means of Producing Nanofibres from Electrospun Webs University of Cambridge The synthesis of a supramolecular double hydrophilic block copolymer (DHBC)and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of a thermoresponsive block and a pHresponsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuliresponsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers. P102 Dibromomaleimide End Functional Polymers by RAFT Polymerization Without the Need of Protecting Groups Mathew Robin Mathew W. Jones, David M. Haddleton, and Rachel K. O’Reilly University of Warwick A dibromomaleimide (DBM) functional chain transfer agent was utilized to afford well-defined PtBA, PMA and PTEGA by RAFT polymerization without the need for protecting group chemistry. Polymerization of the lower kp monomers NIPAM and styrene with this CTA was severely retarded, with evidence suggesting 87 this was due to reversible trapping of propagating radicals by the DBM group. Highly efficient postpolymerization functionalization of DBM-terminated PMA with a model thiol was also demonstrated. P103 Hollow microspheres from responsive tri-block copolymers for controlled release. Multi-layered micellar interpolyelectrolyte complexes (IPECs) are formed from core-shell-corona micelles of ampholytic ABC triblock terpolymers synthesized by living anionic polymerization. Upon complexation of the micelles with oppositely charged polyelectrolytes, changes in the aggregation number can occur. These processes can be suppressed by crosslinking of the micellar core of the precursors leading to well-defined IPEC particles. Even more, complexation with thermo-responsive and bis-hydrophilic block copolymers yielded “smart” IPECs with an LCST transition. Emily Skinner and Prof Gareth Price P106 University of Bath Hollow polymeric microspheres have applications in controlled delivery and ultrasound imaging. The synthesis and characterization of tri-block copolymers containing poly(methacrylic acid) by RAFT will be described along with their formation into novel, cross-linked, thermo-responsive microspheres via a facile sonochemical method. These have been used to encapsulate and controllably deliver a range of hydrophilic and lipophilic molecules including drugs, polymers and salts. P104 New stimuli-responsive block copolymers with controlled structure for polymer-lipossome complexes Joana Mendes A. C. Serra, Patricia Alves, J.F.J. Coelho, P.N. Simões University of Coimbra - Chemical Engineering Department The incorporation of polymers in liposomes is a very interesting strategy to increase their stability in blood and enhance their performance in drug delivery. In this work, stimuli-responsive block copolymers with a cholesterol terminal group were successfully prepared. The synthetic route combined living radical polymerization methods and click chemistry. The block copolymer presented a controlled structure and narrow molecular weight distribution. The presence of cholesterol ensures the affinity of the polymer to the liposome. P105 Multi-layered Micellar Interpolyelectrolyte Complexes from ABC Triblock Terpolymers Eva Betthausen Felix H. Schacher Axel H. E. Müller University of Bayreuth Study on PEO single crystals at single-molecule level Kai Liu, Yu Song, Wei Feng, Ningning Liu, Wenke Zhang, Xi Zhang Tsinghua University Research on the behaviour of a single polymer chain during the crystallization process and the interchain interactions in polymer single crystals may shed light on the mechanism of polymer crystallization, eventually making it possible to direct polymer crystal engineering. Because of the limitations of detection methods, such investigations have been impossible in the past. In this work, we have successfully extracted a single PEO chain from its single crystal and directly measured the interaction strength between folded polymer fragments to be around 40 pN (at a pulling speed of 2 ¦Ìm/s) by a combination of AFM imaging and single molecule force spectroscopy (SMFS). Further study on the possible recrystallization behaviour of the partially extracted PEO chain is under way. Our current study extends the usefulness of SMFS to the investigation of polymer interactions in their condensed states (e.g., in single crystals). We believe that the method established here can be used to study crystallization of various polymers at the single-molecule level. P107 Polymerization of Methyl Methacrylate using PhotoATRP with Low Copper Catalyst Content Dr Jaroslav Mosnacek Marketa Ilcikova Polymer Institute SAS Well-controlled polymerization of MMA at 35 °C was achieved by photoATRP using a Cu catalyst content as low as 50 ppm. Irradiation at > 350 nm provided both a reduction of initially added Cu(II) catalyst complex to a Cu(I) activator and a sufficient rate of polymerization. PMMA with a narrow dispersity and predictable molar mass was obtained with 2-bromopropionitrile initiator. Successful chain-extension polymerization confirmed the living character of the photopolymerization system. 88 P108 P110 Synthesis and Application of Block Copolymers for Improving Lifetime of Organic Solar Cells Novel Organic Catalysts for the Ring Opening Polymerisation of Lactide Dr Harikrishna Erothu Richard Todd and A.P.Dove The continuous use of fossil fuels (coal, oil, gas) that produce CO2, which increases global warming, is drastically damaging our environment. Current silicon-based solar cell technology is extremely expensive to implement on a global scale. This is the major motivation for the development of organic solar cells (OSCs), which attract much attention due to their low-cost, ﬂexibility, lightweight and also their use in large-area devices.3 The simplest and to date, most successful technique is based on solution-processed bulk heterojunction (BHJ) OSCs composed of electron-donating semiconducting polymers and electronwithdrawing fullerides as active layers.The individual layers play a vital role contributing towards the performance and lifetime of the final solar-powered device. The lifetime of current OSCs can be as low as three years. Our aim is to improve further the efficiency and lifetime of OSCs by creating highly original and industrially viable novel block copolymers. The scientific goal of SYNABCO is to provide just a step-change technology platform. SYNABCOs multidisciplinary solution will exploit polymer nanotechnology and so although it will be ‘smart’ it will also be cheap and readily scaleable. Warwick University P109 A proteomic approach to protein adsorption to antibiofouling polymers Gesine Gunkel and Wilhelm T. S. Huck University of Cambridge To date even the best antibiofouling polymers show some residual adsorption when exposed to plasma. A novel protocol to allow proteomic analysis of adsorbed proteins was established, as precise knowledge of the molecules involved will be instrumental to design superior surface coatings in the future. We provide a catalogue of the proteins that are the main challenge for current antibiofouling polymers. Moreover, we show that different chemical structures have no impact on which proteins bind. A detailed study of one of the key adsorbing proteins revealed new insights into protein adsorption to polymer surfaces. The ring-opening polymerisation of lactide using a cocatalyst system comprised of (-)-sparteine and a thiourea results in polymers with low polydispersities and predictable molecular weights. Furthermore, the polymerization occurs with virtually no transesterfication or epimerisation, yielding poly(lactide) PLA with a well defined microstructure. The lack of commercial availability of (-)-sparteine has led us to investigate alternatives that are able to provide such exquisite control of the resultant molecular parameters of the PLA produced. P111 Encapsulation of CeO2 nanoparticles in acrylic latexes Miren Aguirre Maria Paulis, Jose Ramon Leiza Polymat/ University of the Basque Country UPV/EHU Encapsulation of metal oxide nanoparticles in polymer particles has become of particular interest due to the wide range of application of those hybrid materials in coatings, adhesives, medicine and cosmetics. With the incorporation of inorganic nanoparticles into the polymeric matrix enhanced mechanical, optical or adhesives properties of the hybrid materials and new functionalities and applications have been discovered. Several nanoparticles have been encapsulated such as TiO2, ZnO and Fe3O4 however nobody has been able to encapsulate CeO2 nanoparticles successfully P112 Sweet MRI Contrast agents by grafting glycosylated polypeptides from superparamagnetic iron oxide nanoparticles Tushar Borase Ninjbadgar Tsedev, Antonios Kapetanakis, Dermot Brougham, Andreas Heise Dublin City University Herein we report synthesis of mono disperse SPION’s colloids by grafting glycopeptides onto magnetic nanoparticle surface. In this particular case we have grafted alkyne functional propargyl glutamate onto SPION’s surface and clicked with azido galactose to form glycopeptide superparamagnetic iron oxide nanoparticle 89 (GP-SPION’s) hybrids. GP-SPION’s showed exceptional stability in aqueous suspensions and selective binding to lectins. When analysed by NMRD they revealed high r1 of 16 s-lmM-1 and low r2 of 62 s-lmM-1 at a typical clinical frequency of 61 MHz (1.5 T), giving an r2/r1 ratio of 3.9. These values confirm the applicability of the suspensions for positive or r1–weighted imaging at frequencies up to 60 MHz (MRI contrast agents). It also shows that the polymer chains have minimal effect on the interaction of the magnetic moments with bulk water. P113 Benzospiropyran based polymers: synthesis and photochromic response Claudia Ventura Robert Byrne, Fabrice Audouin, Andreas Heise Dublin City University Photo-responsive polymers have been investigated intensively as important elements for the development of smart materials and devices. In this work we report firstly the synthesis of polymethacrylates (PMMA) with a single BSP terminal unit by atom transfer radical polymerization (ATRP) and the investigation of their light responsive. The second part of this work conists of designing well-defined polymer architectures with high density of BSP in defined positions and studying their photochromic properties and their light-dependent supramolecular behaviour. P114 Mass spectrometry analysis of synthetic polymers from the solid state using a direct ambient ionisation technique. Michael Smith Jackie A Mosely, Neil R Cameron, David Parker, Peter Stokes and Aruna S Prakash Durham University Mass spectrometry analyses of synthetic polymers using MALDI and ESI have a number of shortcomings; including solvent solubility issues and the addition of metal salts to promote ionisation. The Atmospheric pressure Solids Analysis Probe (ASAP) is a relatively new ambient ionisation technique and is applied here to the characterisation of low molecular weight synthetic polymers in the solid state. Optimisation of source parameters established a strong signal without the addition of metal salts. Terminal groups and monomers sequences were confirmed using tandem MS experiments. P115 A new hybrid copolymer, the poly(MMA-n-BA-GMAVTES) Dr Peter Wright Infineum With this work we will present a new hybrid copolymer, the poly(MMA-n-BA-GMA-VTES), for this application. This copolymer was cured with different amine curing agents .Their coating properties were evaluated. P116 Biodegradable Vancomycin- loaded nanoparticles for Ophthalmologic Diseases – Endophthalmitis Pedro Cardoso Anatoliy V. Popovb and Tamaz Guliashvilic University of Coimbra - Chemical Engineering Department The use of drug delivery systems presents advantages, such as: increasing efficacy; safety of the used drug; reduced systemic exposure as well as the necessary drug dose, and increasing therapeutic agent access. Nanoparticles are suitable carriers for drug transport and delivery. In this work, vancomycin, a glycopeptide antibiotic, was physically immobilized in poly(lactid acid) nanoparticles by using a double emulsion technique. The nanoparticle was designed to progressively release the antibiotic. For this purpose, vancomycin-loaded nanoparticles having sizes below 500 nm were prepared and their efficiency was evaluated. P117 Controlling Monomer Sequences in Living Anionic Polymerization Paul Brooks Lian R. Hutchings, Adrian Natalello, John N. Hall, Karina Bley, E. Alex L. Eccles, Solomon M. Kimani Department of Chemistry, Durham University Whilst natural polymers such as proteins and nucleic acids have absolute control of the monomer sequence, controlling the distribution of synthetic polymers is much more limited and has generally been neglected.One method is by using templates to ‘recognize’ the incoming monomers. We will report the results of the copolymerization of styrene and DPE to produce a nearalternating copolymer and the copolymerization of butadiene and DPE to yield a perfect alternating copolymer from an equimolar feed ratio. Examples of copolymerizations with DPE derivatives resulted in significant effects on the 90 copolymerization kinetics and in some cases retarded the reaction to such an extent that only oligomers were obtained. However, serendipitously, in one case an ; telechelic polymer was prepared in a novel one step (co)polymerization. Finally we will also report the results of our attempts to produce a sequence controlled terpolymer via a statistical (simultaneous) terpolymerization of three monomers (styrene, DPE and a DPE derivative). P118 means to functionalize inorganic-organic as well as polymeric 3D microscaffolds in a spatially resolved fashion. Our novel photoenol-mediated conjugation strategy entails high efficiency and speed in solution as well as on surfaces, e.g. for the covalent attachment of polymers, small molecules and peptides. It proceeds in a wide range of solvents and neither a catalyst is required nor by-products are formed. Most importantly, control over time and space is inherent owing to its light-induced nature. P120 High MWt acrylonitrile-butadiene architectures via a combination of RAFT polymerization and orthogonal copper mediated azide-alkyne cycloaddition Cyclopentadienyl end-capped polymers for a one-step functionalization of Carbon Nanotubes Christoph Dürr, Sebastian G. J. Emmerling, Andreas Kaiser, Sven Brandau and Christopher Barner-Kowollik Nicolas Zydziak, Christof Hübner, Michael Bruns and Christopher Barner-Kowollik, Karlsruhe Institute of Technology Karlsruhe Insitute for Technology The herein applied modular ligation technique is a powerful route to allow the synthesis of narrow distributed acrylonitrilebutadiene copolymers within a commercially interesting molecular weight range above 60 000 g mol-1. Our earlier studies showed that acrylonitrile-butadiene rubber with molecular weights higher than 60 000 mol-1 and low polydispersity cannot be obtained via a classical sequential RAFT process. Moreover, the incorporation of alkyne functions into the polymer was proven to be an efficient tool for the controlled cross-linking of linear acrylonitrile-butadiene copolymer strands as well as the introduction of short chain branches, as for example alkyl moieties. These results are providing the first successful approach to apply modular conjugation techniques for the generation of this industrially highly important polymer class. We report on a complete study for characterizing polymer chains grafted to non-modified Single Walled Carbon Nanotubes (CNTs) via a facile Diels-Alder reaction. The functionalization of the CNTs (dienophile) with cyclopentadienyl (diene) end-capped polymers occurs without any preliminary treatment of the CNTs. The reported approach represents a very convenient and facile method for fabricating, in a one-pot reaction, CNTs composites and hybrid materials. P119 Towards regiospecific and micro-/nano-resolved surface biofunctionalization Thomas Pauloehrl, Guillaume Delaittre, Benjamin Richter, Martin Bastmeyer, Christopher Barner-Kowollik Karlsruhe Institute of Technology (KIT) Cell behavior and differentiation are not only influenced by biochemical cues but also by physical properties of the cell environment such as its geometry, topography and stiffness. To investigate these aspects, novel three-dimensionally defined microscaffolds have been developed thanks to direct laser writing (DLW), a two-photon polymerization method. However, the precise spatial distribution of cell-adhesive sites remained a challenge. To address this issue, we have chosen light as a P121 Miktoarm Starpolymers via Cyclodextrin-Driven Supramolecular Self-Assembly Bernhard V.K.J. Schmidt Martin Hetzer, Helmut Ritter and Christopher Barner-Kowollik Karlsruhe Institute of Technology We report the formation of a novel class of supramolecular miktoarm starpolymers via cyclodextrin host/guest chemistry. RAFT polymerization from difunctional guest- or alkynecontaining chain transfer agents and copper(I)-catalyzed azide– alkyne cycloaddition leads to host- and guest-containing acrylamido polymers, namely poly(N,N-dimethylacrylamide) and poly(N,N-diethylacrylamide). Susequently, a supramolecular miktoarm starpolymer is formed and characterized via DLS and 2D ROESY-NMR. 91 P122 Dendronised Polymer Architectures for Fuel Cell Membranes Mads Møller Nielsen, Ivaylo Dimitrov[1], Shogo Takamuku[2], Patric Jannasch[2], Katja Jankova[1] and Søren Hvilsted[1] [1]Department of Chemical and Biochemical Engineering, Danish Polymer Centre, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Technical University of Denmark Hydrogen powered Proton Exchange Membrane (PEM) Fuel Cell cars are scheduled for large-scale commercial launch in 2015 The current PerFluoroSulfonic Acid (PFSA) benchmark membranes need significantly improved performance, cost and durability for the technology to become viable. In an attempt to take a less travelled road, the current study investigates some alkylic dendronised architectures as PEM candidates. Sulfonated dendritic structures are covalently attached by the efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) to a nonfluorous polysulfone (PSU) backbone that has been modified to contain an azidomethyl group at three different degrees of substitution. Initial proton conductivity measurements under wet conditions at room temperature show the potential of the concept. P123 1,3,5-Triazine Based Microporous Organic Polymers Dr Shijie Ren, Robert Dawson, Andrea Laybourn, Jia-xing Jiang, Dave J. Adams, and Andrew I. Cooper P124 Enzyme Responsive Microgels Judith McCann Brian Saunders University of Manchester Exploring methods of producing enzyme responsive systems through NIPAm containing microgels. The focus is on properties related to proportions of copolymer and temperature, and how copolymers can be used to give high concentrations of amine groups dispersed throughout particles. P125 Macromolecular Ruthenium Complexes as Anti-Cancer Agents Bianca Blunden Donald Thomas, Martina Stenzel University of New South Wales Ruthenium anti-cancer agents have shown promise as they possess multiple mechanisms of activation and internalisation within the body. The disadvantages associated with low molecular weight agents can be addressed by incorporating complexes, having anti-cancer activity, into polymer structures. The RAPTA series of complexes were chosen for initial investigation as they provide a site of attachment to the polymer. Due to the complexities of analysing polymer structures, a small molecule model compound was first synthesised and analysed in detail. This model was then used to investigate the attachment of the complex to polymer moieties. P126 University of Liverpool Microporous organic polymers (MOPs) are attracting increasing attention due to their potential applications in areas such as gas adsorption, separation, and heterogeneous catalysis. Compared with their inorganic or hybrid counterparts, such as silica, metal oxides, zeolites, and metal-organic frameworks (MOFs), MOPs have possible advantages in terms of combining wide synthetic diversity with reasonable chemical and thermal stability. 1,3,5Triazine is an interesting building unit with high electron deficiency and spatial coplanarity. In this talk, we will report synthesis and characterizations of a range of triazine-based microporous polymers. Comparison of synthetic methods and gas sorption properties with previously reported MOPs and some other unique properties arising from the incorporation of the triazine unit will be shown. Transition from OLED to OPV Compatible for Hybrid Organic-Inorganic MEHPPV: CdSe Nanocomposites Aarti Mehta Shailesh N Sharma, A K Srivastva, Suresh Chand Natonal Physical lab, India In this work, we demonstrate the effect of surface modification of as-synthesized spherical Cadmium selenide Quantum dots of size (5-7 nm) by using various ligand such as (TOPO, Oleic acid and Oleylamine). The as-prepared CdSe QDs are highly luminescent, monodispersive and exhibit energy transfer effects upon their dispersion in MEH-PPV polymer matrix. Oleylamine capped CdSe QD’s are showing maximum energy transfer as compared to Oleic acid and TOPO capped CdSe QDs. After establishing the Optical and structural properties, we found that these CdSe QDs are greatly applicable Organic light 92 emitting diode application. Now these synthesized quantum dots are treated with a specific chemical treatment. Morphologies of chemically treated CdSe QDs are checked by transmission electron microscopy and photoluminescence quenching experiment shows the enhancement in charge transfer is obtained. This is mainly due to the partial removal of capping ligand attached to the CdSe Core. The bulky group present on the surface of CdSe core creates hindrance in the interaction between polymer and CdSe QDs. Enhancement in charge transfer make compatible to existing CdSe QDs for organic photovoltaic application. solutions, and the equilibration dynamics upon cosolvent removal. The importance of this study is that as-synthesized CdSe QDs show effective energy transfer whereas after chemical treatment, it shows enhanced charge transfer mechanism which makes their corresponding nanocomposites useful for different applications in organic electronic devices such as efficient electroluminescent (OLED) and photovoltaic (OPV) devices respectively. University of Nottingham P127 Synthesis of glycopolymer via ATRP and CuAAC click chemistry Guangzhao Li D.M.Haddleton P129 PEO-PPO-PEO Block Co-Polymers: A Systematic Study into the mechanisms behing their biological effects (Or how I learnt to stop worrying and love the membranes) Martin Redhead Dr. Guiseppe Mantovani, Prof. Cameron Alexander, Dr. Cynthia Bosquillon Here we describe a systematic approach to targeting the structure of PEO-PPO-PEO polymers to cause desirable biochemical responses within cultured cells. We have employed a number of quantitative assays, including cytotoxicty, haemolytic and reporter gene systems. The mechanisms by which these effects have been achieved have also been studied. Polymers with an Mn PPO of around 2 kDa and consisting of 40% PEO by weight were found to have the greatest disruptive effect on biological membranes, this disruption was found to be the cause of their biological effects. University of Warwick P130 A kind of P(TMS-PgMA) polymer was synthesized by ATRP using a disulfide-based bifunctional initiator. Subsequently, a novel series of glycopolymer with different sugar units were successfully prepared by employing the CuAAC “co-click” strategy. P128 Structural changes in block copolymer micelles induced by cosolvent mixtures Elizabeth Kelley Thomas P. Smart, Jonathan E. Seppala, Sarah D. Hann, Millicent O. Sullivan, Thomas H. Epps, III University of Delaware The internal structure of block copolymer micelles was manipulated through the use of cosolvent mixtures. While the micelles remained starlike, the micelle core-corona interfacial tension and micelle size decreased upon cosolvent addition. The detailed effects of the reduced interfacial tension on micelle structure were probed using contrast variations in small angle neutron scattering (SANS) experiments. We are investigating the stability of these solvent-induced structures in aqueous Supercritical fluid foaming: a novel route to polymeric allografts? Matthew Purcell Edward Tayton, Kevin Shakesheff, Steve Howdle, Richard Oreffo University of Nottingham Morselised allograft is the current ‘gold standard’ material used for impaction bone grafting. Expense and risk of disease transmission are drivers for an alternative. Supercriticial CO2 foamed (SCF) PDLLA, and PDLLGA have been investigated as alternatives to allograft: mechanically; in vitro for mesenchymal stem cell adhesion, proliferation, and osteogenic differentiation; and in vivo (murine and ovine) for bone regeneration. SCF PDLLA with hydroxyapatite (10%) showed good cell proliferation, differentiation, and bony like matrix formation was been observed in vivo. 93 P131 Imidazolium Hydrogen Carbonates and Imidazolium Carboxylates as a Genuine Source of N-Heterocyclic Carbenes for Various Room Temperature Organocatalyzed (Macro)molecular Reactions Maréva Fevre, Julien Pinaud, Paul Coupillaud, Alexandre Leteneur, Yves Gnanou, Karinne Miqueu, Jean-Marc Sotiropoulos, Joan Vignolle and Daniel Taton LCPO In the past few decades, N-heterocyclic carbenes (NHCs) have not only emerged as powerful ligands for transition metals but also as true organocatalysts for various (macro)molecular reactions. Next, such [NHC(H)][HCO3] precursors and their NHC-CO2 adducts dehydrated counterparts were independently employed as organic pre-catalysts in selected known NHC-catalyzed reactions of molecular chemistry and polymer synthesis. NHCCO2 adducts were obtained by carboxylation in THF of in situgenerated related free NHCs and were found less stable, both in the solid state and in solution, than the [NHC(H)][HCO3] salts. P132 Novel thermoplastic poly(ester/amide urethane)s from fatty acid methyl esters Lise Maisonneuve, T. Lebarbé, E. Cloutet, B. Gadenne, C. Alfos and H. Cramail Laboratoire de Chimie des Polymères Organiques LCPO World-wide potential demands for replacing petroleum-derived raw materials with renewable ones are quite significant from the societal and environmental points of view. In this present work, new diols containing ester, esteramide and amide linkages from castor and sunflower oils were obtained by transesterification, amidation and thiol-ene reaction. [1][2][3][4][5] The starting biosourced materials used are methyl undecenoate and methyl oleate, 1,3-propanediol, isosorbide and 1,4-diaminobutane. The former three can be respectively obtained from glycerol, starch and glutamic acid. A series of amorphous and semi-crystalline polyurethanes have been obtained by varying the diol structure. The relationship between the diol and diisocyanate structures and properties of the so-formed polyurethanes will be discussed in the presentation in the light of DSC, DMA, TGA and X-ray analyses as well as tensile experiments. P133 Transforming polylactide into value added materials Frank Leibfarth, Nicholas Moreno, Alex Hawker, Justin Shad, and Craig J. Hawker University of California Santa Barbara We report the recycling of commodity polylactide from packaging material into value-added small molecule lactate esters through rapid and quantitative transesterification employing triazabicyclodecene (TBD) as an organocatalyst. Special attention is given to the scope of these reactions, with optimized conditions providing lactate esters at room temperature with full retention of stereochemistry. This methodology is further employed on polyglycolide, displaying its generality toward polyester starting material and its utility in making novel small molecules. P134 ATRP synthesis and catalytic performance of new polymer-supported phosphine ligands Andrés Fernando Cardozo Perez, Eric Manoury, Carine Julcour, Jean-François Blanco, Henri Delmas, Florence Gayet, Rinaldo Poli Laboratoire de Chimie de Coordination Phosphines are common electron donating ligands that can coordinate many important metals in catalysis (e.g. Ru, Rh, Pd); for instance, Wilkinson’s work revealed the potential of rhodium phosphine catalysts for the hydroformylation reaction of alkenes. Owing to the high price of rhodium and to avoid subsequent purification steps of the products, supported or immobilised phosphine ligands for catalysts recovery and recycling is a subject of interest in catalytic hydroformylation process design. In this work, a series of polystyrene supported tertiary phosphine ligands were prepared by copper catalyzed atom transfer radical polymerization (ATRP), involving direct copolymerization of styrene and styryldiphenylphosphine (SDPP). Copolymerization of the two monomers at different molar ratios showed a decreasing level of control as the SDPP molar fraction (fSDPP) increased, with a satisfactory level of control being achieved for fSDPP = 0.25 (constant concentration of growing “living chains”, linear Mn growth with conversion and low dispersity). Copper-free polymers with different chain lengths were prepared and tested as polymeric ligands in the Rh-catalyzed hydroformylation of 1-octene. The polymeric ligands yielded higher linear/branched selectivity and lower 94 activity relative to PPh3 at the same P/Rh ratio. The selectivity increased slightly as a function of the polymer chain length. P135 P137 A new poly(sulfide amine)for nucleic acids delivery Anna Maria Giordano Nathalie Lavignac Polyglutamic acid (PGA) based conjugates for light based in vivo imaging of disease related enzymes Aroa Duro Castaño I. Tranchant2, H.Y. Hu3, M. Vizovišek4, M. Barz1, M. Amoura2, F. Beau2, U. Repnik4, C. Schultz3, U. Wendt3, V. Dive2, B. Turk4, M. J. Vicent1, Centro de Investigación Príncipe Felipe Polyglutamates are highly biocompatible, biodegradable and multifuntional polymers, which have been successfully used as building blocks in polymer drug conjugates and polymeric micelles for various medical applications ranging from cancer to ischemic processes. In this context we report the use of polyglutamates as carriers of highly specific smart probes for specific proteases (MMP-12, cathepsin B and cathepsin S) to enhance site-specific accumulation. The study in animal models is currently under development as well as the combination of these highly specific smart probes with targeting moieties for cancer or osteoarthritis in a polymeric system in order to improve tissue targeting. P136 Precision macromolecular engineering of novel block copolymers for use as stabilisers in non-aqueous dispersion polymerisations Kate Belsey Claire Topping*, Louise Farrand*, Simon Holder *Merck Chemicals Ltd University of Kent Poly(methyl methacrylate)-block-poly(octadecyl acrylate) stabilisers (synthesised via ATRP) were used in the non-aqueous dispersion polymerisation of MMA with cross-linking additives. Well-defined PMMA particles with diameters from 340 nm to 1.2 µm. These colloidal dispersions showed thermo-responsive gelation. Medway School of Pharmacy A new SS-PAA was synthesised by Michael polyaddition of cystamine bisacrylamide, 2-methylpiperazine and hydroxyethylethylenediamine. The chemical structure was confirmed by 1H-N; (ppm): 1.33 (d, 3H, CH3 end chain), 1.43 (d, 3H, CH3 2MP), 2.71-2.77 (m, 16 H, H2C-C=O; CH2S), 3.32-3.86 (m, 31 H, CH2-N, O=CH2-CH2-N, CH2-N2MP, CH2 DHE), 3.843.88 (CH2OH). The molecular weight was determined by GPC (Mw: 3,700 g/mol, PDI 2). Gel retardation assays demonstrated that the polymer was able to bind pDNA and could protect the plasmid from DNase degradation. Transfection experiments showed that the polymer could promote intracellular delivery of pGL3 plasmids in HEK293 cells with a transfection efficiency comparable to PEI but with lower cytotoxicity. P138 L-Proline functionalized polymers as supported organocatalysts Annhelen Lu T. P. Smart, T. H. Epps III, D. A. Longbottom, R. K. O’Reilly UNIVERSITY OF WARWICK A range of well-defined copolymers of styrene and L-proline functionalized styrene (5–11 kDa) using reversible addition– fragmentation chain transfer (RAFT) polymerization techniques have been synthesized. Their uses as supported catalysts have been explored. Upon deprotection of the L-proline functionalities, the solution self-assembly of these copolymers was investigated in mixed solvent systems. The resulting assemblies were characterized by dynamic light scattering, transmission electron microscopy (on graphene oxide substrates, along with cryo-TEM and tomography), and scanning electron microscopy. The application of these functional assemblies as supported catalysts for the aldol condensation reaction was explored using cyclohexanone and 4nitrobenzaldehyde. The rate and selectivity of solution catalysis in this self-assembled system were comparable to those of unsupported L-proline. One significant advantage of our polymeric system was that the polymer support could be utilized at lower catalyst loadings with comparable activity and also could be recycled a number of times while maintaining activity and selectivity. 95 P139 Hierachical structure of polymeric systems in water with cucurbit[8]uril Dr Jesus del Barrio, Eric A. Appel, Xian Jun Loh, Oren A. Scherman contribution the case of asymmetric poly(isoprene-bferrocenylsilane) diblock copolymers will be presented, where the crystallizable block contains a mixture of ferrocenyldimethylsilane and ferrocenyldiethylsilane repeating units. Moreover, the self-assembly behaviour of polylactide and polycaprolactone-based diblock copolymers under various processing conditions will be discussed. P141 University of Cambridge Manipulation of matter at the molecular scale through the self assembly of supramolecular systems is a fascinating and challenging area. There has been considerable effort to develop novel self-organized systems in water. A promising self-assembly motif to address the challenges of molecular self-organization in aqueous media is based on the barrel-shaped cyclic oligomer cucurbit[n]uril CB[n]. Particularly, CB[8] is a remarkable host molecule as it is able to bind two organic guests simultaneously with a high association constant. In this work we show how CB[8] can be utilized to either modify the properties of stimuliresponsive polymers or bring together polymer chains and/or oligopeptides in a reversible manner to obtain hierarchical assemblies. We are exploring fundamental rules that govern reversible polymer aggregation with the aim of producing synthetic materials capable of exerting a specific function in aqueous media. This project addresses major challenges in polymer science such as understanding the factors that determine the binding dynamics of supramolecular polymers in water and exerting reversible control over macromolecular aggregation with impact on substance delivery applications or viscosity modification. P140 Block Copolymer Synthesis in Supercritical Carbon Dioxide - A Route to Nanostructured Microparticles James Jennings Maria Beija, Alexandre Richez, Kristofer Thurecht, Kevin Jack, Steve Howdle University of Nottingham Block copolymers of many structures and properties have been synthesised in a RAFT dispersion polymerisation in supercritical CO2. The resulting particles are found to possess internal nanostructures that are tuneable by changing the volume fractions of the polymers, as expected, but also by changing the chemical nature of the block copolymer. The results strongly suggest a profound effect of CO2 on the phase behaviour, in which it is expected to act as a block selective solvent P142 Well-define polyglutamates with versatile architectures Dr Richard Mark England Aroa Duro1, Inmaculada ConejosSánchez1, Stefan Hoffman2, Karsten Mäder2, Maria J. Vicent1 New Crystalline-Coil Block Copolymers: Synthesis and Self-assembly in Selective Solvents 1 Polymer Therapeutics Lab. Centro Investigación Príncipe Felipe, Valencia, Spain; 2 Martin-Luther-University HalleWittenberg, Institute of Pharmacy, Halle, Germa Dr Vasilios Bellas Felix H. Schacher and Ian Manners Centro de Investigacion Principe Felipe University of Bristol The rational development of an effective drug delivery system requires the understanding of the complex interplay between the drug carrier and the biological system. Here we set out to investigate, characterise and understand the role of controlled macromolecule engineering in biological settings with the specific aim to develop synthetic objects with controllable length-scales and adequate body distribution to be used as polymeric carriers for targeted drug delivery. The synthesis of these materials is achieved from the ring opening polymerisation of the benzyl-L-glutamic acid NCarboxyanhydride (NCA) by nucleophilic initiators. We have established in the laboratory a synthetic strategy to functional polyglutamates with well-defined structure, adjustable molecular weight (Mw) and low dispersity (D = Mw/Mn <1.2) The field of block copolymer cylindrical micelles has been significantly expanded over the last years. The cylindrical geometry is particularly suited for specific technical applications (drug delivery, toughness modifiers) compared to the spherical one. Despite the fascinating properties of cylindrical micelles, it is difficult to access them from coil-coil diblock copolymers, because they form only within a relative narrow composition window. However, cylindrical structures can be generated by a crystallization-driven living self-assembly process of highly asymmetric diblock copolymers, comprised of a much shorter crystalline core-forming block compared to the longer coronaforming coblock, enabling the precise control of micelle length and affording narrowly distributed aggregates. In this 96 applying the ring opening polymerisation (ROP) of Ncarboxyanhydrides (NCA) with novel initiators. P143 Efficient synthesis of organic/inorganic latexes with welldefined morphologies by controlled radical polymerization in aqueous dispersed media Dr Elodie Bourgeat-Lami N. Zgheib, M. Lansalot, F. D'Agosto, X. Qiao, B. Charleux, E. Bourgeat-Lami CPE Lyon - Laboratoire de Chimie, Catalyse, Polymères et Procédés (C2P2) - LCPP group Hydrophilic macroRAFT agents and macroalkoxyamine initiators were used as both control agents and stabilizers to produce a series of waterborne nanostructured organic/inorganic particles by controlled radical polymerization in aqueous dispersed media. Different inorganic materials were investigated including silica and cerium dioxide particles. We report i) the synthesis of the macroRAFT agents and of the macroalkoxyamine initiators, ii) their adsorption on the inorganic particle surface, and iii) the subsequent formation of composite colloids of various morphologies. P144 Colloidal suspensions of pyroelectric polymer particles synthesized by dispersion polymerization in polar medium Dr Julien Parvole, M. Lansalot, B. Charleux, E. Bourgeat-Lami, A. Al-Zein, G. Dezanneau, R. Doherty, J.-F. Hochepied, M.-H. Berger, T. Delahaye CPE Lyon - Laboratoire de Chimie, Catalyse, Polymères et Procédés (C2P2) - LCPP group In the frame of a research work aiming at developing a new method for converting thermal power into electrical power using colloidal suspensions of pyroelectric nanoparticles, polymer lattices based on polyacrylonitrile were synthesized by dispersion polymerization in polar medium. The influence of parameters such as acrylonitrile content or the nature of the stabilizer on the resulting morphologies and suspensions properties (crystallinity, dielectric constant) was investigated, opening the door to a large range of specific ferroelectric colloidal suspensions. P145 Hybrid radical/catalytic mechanisms for the copolymerization of ethylene and polar vinyl monomers Dr Vincent Monteil, Alexandra Leblanc, Etienne Grau, Christophe Boisson, Roger Spitz C2P2 Laboratory / CNRS, University of Lyon, CPE Lyon The incorporation of polar monomers in polyolefins is very important in polymerization chemistry. Commercial processes mainly require radical polymerization, thus limiting the range of materials available. The metal-catalyzed copolymerization of olefins and polar monomers has won some successes but activities remain low. We recently propose hybrid radical/catalytic alternatives using nickel complexes involved simultaneously in radical and coordination-insertion mechanisms. Multiblock copolymers of ethylene and a broad range of polar vinyl monomers are thus prepared. P146 Design of Encapsulation Strategies for the Insertion of Self-Healing Agents in Thermosets Dr Roberto Teixeira Filip Du Prez, Catheline Colard, Alexandre Beirão, Ivo Pais, Patrice Vandendaele, Hubert Rahier, Tania Dey Ghent University, Department of Organic Chemistry, Polymer Chemistry Research Group Matrixes such as thermoset materials undergo damages over time due to external forces such as cyclic stresses and climate conditions. Microcapsules represent reservoirs of healing agents which are dispersed into materials. Upon crack formation, the microcapsules present in the matrix should break (and not debond) and release their reactive liquid content, allowing the material to recover its strength. Innovative strategies for the encapsulation of new designed self-healing agents and its improvements on the healing efficiency of different materials will be discussed. P147 Comparison of different ‘click’ chemistry approaches for functionalization of polyurethane foams Dr Thu Nguyen Jan Devroede, Kathleen Plasschaert, Laura Jonckheere, Nancy Haucourt, Filip E. Du Prez Ghent University Although click chemistry has been widely used in the functionalization of polymeric materials and surfaces, there have 97 been few studies on surface modification using ‘click’ approaches of cellular polymers, such as foams. In this contribution, different ‘click’ reactions, including the copper(I)catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC), thiol-ene and thiol-yne radical addition, and Diels-Alder cycloaddition reactions were explored for click functionalization of polyurethane foams, in a comparable manner, in term of kinetics and conversion. P148 Gd(III)-decorated nanoparticles for MRI Dr Mariana Beija, Yang (Daniel) Li, Sophie Laurent, Andrew B. Lowe, Thomas P. Davis, Cyrille A. Boyer CAMD - UNSW Low molecular Gd(III) chelates are used widely as contrast agents for Magnetic Resonance Imaging (MRI). However, they are efficient only at relatively high doses and at low magnetic fields. To overcome these drawbacks, we developed nanoparticulate systems based on poly(oligoethyleneglycol acrylate) polymers and containing Gd(III) chelates. This strategy leads to relaxivity enhancement and increase of the blood circulation times, making these excellent candidates for blood pool MRI. P149 Synthesis and Characterization of PCM Nanoparticles Suspensions by Miniemulsion Guanhua Zhang, Changying Zhao, Adam Morgan, Nicholas Ballard, Stefan A. F. Bon. School of Engineering, University of Warwick A series of prepared phase change material (PCM) suspensions containing n-octadecane nanoparticles were synthesized via miniemulsion. The mass ratio of PCM to water and surfactant was: 10:90:2, 20:80:2, 30:70:2, 40:60:2 in prepared phase change slurries (PCSs), respectively. The particle morphology was studied by Transmission Electron Microscopy (TEM). Then the thermal conductivity of PCSs was measured by the thermal conductivity meter. The melting/crystallizing temperature and fusion heat/crystallization heat of the PCSs were obtained from a DSC (differential scanning calorimetry) during the heating/cooling process. Physical properties, such as viscosity, diameter and its size distribution of the PCSs were investigated by rheometer and dynamic light scattering (DLS). All PCSs presented narrowly size-distributed and stabled particles. P15 A Study of the Assembly and Catalytic Application of Palladium Containing Homopolymers Joseph Patterson University of Warwick Amphiphilic molecules which self-assemble to form nanostructures are of great interest due to potential applications as nanoreactors, drug delivery vehicles, molecular imaging agents and nano-sized electrical devices.(1) Recently it has been shown that the hydrophobic end groups incorporated into hydrophilic polymer via RAFT can induce the formation of self-assembled structures in water leading to readily accessible nanostructures. (2) Here the self-assembly of hydrophilic polymers (induced via a hydrophobic SCS-pincer ligand) is investigated along with their use as recyclable catalysts for aqueous phase palladium catalysis. P151 Functionalised O-carboxyanhydrides from renewable resources Michael Bennison Dr. Andrew Dove University of Warwick The ring-opening polymerisation (ROP) of 1,3-dioxolane-2,4diones, O-carboxyanhydrides (OCAs) provides an excellent route for the controlled synthesis functionalised poly(ester)s with much greater reaction rates than the equivalently functionalized glycolide monomers. Our work has focused on the synthesis of a range of functional OCAs from renewable sources and mechanistic aspects of the polymerizations. P152 Labeled Polymeric Micellar Nanoparticles Lyndsay Randolph Matthew P. Thompson, Michael E. Hahn, Carrie R. James, Ashley N. Davalos, and Nathan C. Gianneschi University of California, San Diego As synthetic chemists, we increasingly seek methods, techniques and strategies for building complexity into molecular systems. This is especially true and challenging in the context of nanomaterials. Some of the challenges in preparing complex materials include characterization, the ability to track materials 98 once self-assembled and observing their behavior in vivo. With this in mind, ring-opening metathesis polymerization (ROMP) provides a tool for the generation of well-defined polymers of low polydispersity and highly functionalized architectures. In order to incorporate visualizable labels into amphiphilic ROMP polymers, a variety of monomeric units and termination agents have been synthesized, polymerized, and subsequently selfassembled into micellar architectures. The newly formed labeled micellar materials allow for characterization of particle stability with fluorescent lifetime methods and visualization by various spectroscopic techniques. P153 Low Symmetry Poly(ferrocenyldimethylsilane) Block Copolymer Micelles Dr Paul Rupar, Laurent Chabanne, Mitchell A. Winnik, Ian Manners University of Bristol The solution phase crystallization-driven self-assembly of poly(ferrocenyldimethylsilane) (PFS) containing block copolymers enables the creation of cylindrical micelles and block co-micelles of well-defined lengths and length distributions. This talk will discuss the effects of corona crosslinking on the growth of PFS containing micelles and the formation of previously unattainable self-assembled structures, including Janus-like cylindrical micelles and amphiphilic micelles. P155 Modifying polybutadiene surface properties with additives made via living anionic polymerisation Dr Solomon Kimani., Hardman S. J., Thompson R. L., Clark N., Wu J. J. and Hutchings R. L Durham University The ability to control polymer surface properties such as adhesion, wettability, hydrophobicity and biocompatibility while retaining favourable bulk properties is desirable for many applications. One way of achieving this is by blending the host polymer with small amounts of end-functionalised polymer additive that has a similar backbone structure to the matrix, We report here the synthesis of well-defined, polybutadiene additives; chain-end functionalised with either multiple fluorocarbon or hydroxyl groups. Additives containing low surface energy fluorocarbon groups were made by end-capping polybutadienyllithium prepared via living anionic polymerisation, while the high surface energy, hydroxyl functionalised additives were made via a combination of living anionic polymerisation and “click chemistry”. The wettability of pure additives on the surface of a silicon wafer and Teflon™ were also determined by static contact angle measurement. We anticipate that these additives could be utilised to disperse and stabilise nanoparticles in nanocomposites, and enhance the adhesion of polybutadiene onto low and high energy surfaces. P154 P156 Synthesis of Amphiphilic Glycopolymers and their Selfassembly into Giant Vesicles Photo-‘click’ thiol-ene derived polyhipes as biodegradable 3D cell culture scaffolds Dr Ahmed Eissa Prof. Neil R. Cameron Dr David Johnson Prof. Neil R Cameron Durham University M. Didsbury Herein, we present the utilization of CuAAC Click reaction to prepare glycosylated PE–PEO block copolymers. Moreover, we demonstrate the synthesis of novel amphiphilic glycopolymers via post-functionalization with aminoglycosides of preformed well-defined block polymeric activated ester prepared by RAFT polymerization. Durham University The formation of giant vesicles from the prepared amphiphilic glycopolymers via the electro-formation technique is established. The binding interactions of glycopolymers with lectins are currently being conducted. Thiol-ene and thiol-yne photo-‘click’ chemistry, involving multifunctional thiols and acrylates, can be used to prepare polyHIPE materials by step-growth network formation. Fast cure times produce consistent materials despite the HIPEs comparative instability. The materials have tuneable mechanical properties, may be functionalised, and biodegrade in cell culture medium. The materials are shown to be suitable for keratinocyte cell culture and thus are promising scaffolds for tissue engineering. P157 99 Olefin metthesis as a tool for the synthesis and modifcation of defined macromolecules showing the relationships between various assays for assessing multivalent carbohydrate binding. P160 Dr Lucas Montero de Espinosa Michael A. R. Meier Karlsruhe Institute of Technology Olefin metathesis has been used as a tool for the synthesis of defined polymeric structures (via step-growth polymerization), as well as for the modification of polymers with pendant double bonds. Key for this purpose is the high cross-metathesis selectivity between acrylates or vinyl ketones and terminal olefins, which has enabled the synthesis of linear and starshaped polymers and diblock copolymers, and the pendant chain modification of defined polymers using different functional olefins P158 Preparation of functional polycarbonates: from controlled polymer architectures to anti-angiogenic applications Synthesis and Functionalization of Well-Defined Polythiol Copolymers Dr Renaud Nicolay, Morgane Le Neindre and Ilias Iliopoulos ESPCI A simple methodology to prepare well-defined polythiol copolymers by controlled radical polymerization was developed. Monomers carrying various thiol protecting groups were prepared in two high yield steps. Polythiols were obtained by copolymerizing the functional monomers and subsequent aminolysis of the protecting groups. Polythiol copolymers were quantitatively functionalized via thiol;ene addition, Michael addition and thiol;disulfide exchange, exemplifying the potential of polythiol copolymers for the preparation of functional materials. Dr Laetitia Mespouille Michal Kawalec, Géraldine Piel, Brigitte evrard, Denis Mottet, Olivier Peulen, Philippe dubois P161 University of Mons Supramolecular chemistry for control of CNT dispersions Controlled synthesis of functional polycarbonates has gained an increasing attention in reason of their biocompatibility and biodegradability, making them very desirable for biomedical applications as drug delivery devices or as anti-angiogenic vector of 3rd generation in the treatment of cancer. In this particular context, it was found that morpholino and guanidinium-based polycarbonates of various topologies were very efficient in the complexation of SiRNA and to transfect endothelial cells Alexandre Prevoteau, Corinne Soulié-Ziakovic, Ludwik Leibler P159 Detection and inhibition of pathogens using multivalent scaffolds Sarah-Jane Richards Gou, Y.; Jones, M. W.; Hunabun, M. I.; Haddelton, D. M.; Gibson, M. I. The University of Warwick Adhesion to carbohydrates on cell surfaces is often the first step in bacterial infection. Protein-carbohydrate interactions are weak; nature circumvents this by multivalent presentation of the carbohydrate moiety. Glycopolymers have therefore attracted attention as inhibitors of this binding event. Tandem post-polymerisation modification is a powerful tool for creating libraries of glycopolymers. Here we present investigations into the role of linker length with two distinct lectins and data ESPCI, Laboratoire Matiere Molle et Chimie We propose a simple and versatile method to reversibly control dispersion and floculation of CNT through host-guest supramolecular associations. MWCNTs are grafted with Thymine (Thy) using Sandmeyer reaction. We show that host-guest interaction can be used to reversibly end-graft polymers chains on Thy functional groups and control dispersion-floculation and redispersion processes in various solvents and temperature range. P162 pH-Responsive Block Copolymer Vesicles for Intracellular Delivery of Therapeutic Agents Dr Efrosyni Themistou, Giuseppe Battaglia, Steven P. Armes University of Sheffield Biocompatible pH-responsive block copolymers allow effective intracellular delivery of therapeutic agents. We exploit polymerisation-induced self-assembly (PISA) to prepare pHresponsive block copolymer vesicles based on biocompatible 2- 100 (methacryloyloxy)ethyl phosphorylcholine, pH-sensitive 2(diisopropylamino)ethyl methacrylate and 2-hydroxypropyl methacrylate using RAFT chemistry in concentrated aqueous solution at pH 7-8 and 40ºC. Routes for in situ loading of such vesicles are explored. P163 Understanding the function of Ice growth inhibiting macromolecules Tom Congdon University of Warwick Antifreeze proteins found in both plants and animals have many potential applications in healthcare and industrially. However these proteins are not readily available and their mechanism of action is poorly understood. Here we address this challenge by a biomimetic approach using synthetic macromolecules obtained by controlled radical polymerization techniques. These polymers are demonstrated to have unique properties previously only associated with antifreeze proteins. Complementary in silico simulations are used to probe the molecular-level details of this process. P164 The synthesis of branched functional polymers Kayleigh McEwan P165 Automatic Continuous Online Monitoring of Polymerisation Claudia Houben M. A. Liauw, D. M. Haddleton, A. Lapkin University of Warwick Catalytic Chain Transfer Polymerisation (CCTP) is a controlled synthesis for low molecular weight polymers. These polymers find applications in the coatings, detergents and water treatment industries. Furthermore CCTP is readily incorporated into dispersed phase polymerization techniques such as miniemulsion and emulsion polymerization. In this study a CCTP reaction was carried out with glycidyl methacrylate (GMA) as the monomer using V-601 as the initiator and CoBF as a chain transfer agent. The reaction was followed by Automatic Continuous Online Monitoring of Polymerisation (ACOMP). With ACOMP it is possible to obtain information throughout the reaction. A small flow of sample is taken from the reactor continuously, diluted if necessary and finally analysed. The analytical part of the reactor contains several detectors including LS, UV, RI and viscometry detectors, so snapshots of the reaction mixture are obtained as a function of reaction time. With these detectors a lot of useful information can be obtained during the reaction to improve the product and reduce costs. Another goal is to control reaction conditions online to achieve the targeted product. P166 The University of Warwick Catalytic chain transfer polymerisation (CCTP) is a controlled polymerisation technique discovered in 1975, since then it has had extensive use in industry in the coatings and surfactants industry, but has received little academic publicity. An excellent facet of CCTP is the retention of terminal vinyl functionality in the product; in addition the catalytic nature of the cobalt chain transfer agent means that only a small amount (ppm) of cobalt chain transfer agent is required. CCTP has been reported to be useful for the synthesis of hyperbranched polymers from commercially available multivinyl monomers such as ethyleneglycol dimethacrylate (EGDMA). In this current work a number of multivinyl monomers, both commercial and noncommercial, have been employed to create a range of branched polymers, possessing a high level of terminal vinyl functionality. Thio-Michael addition is used to exploit these peripheral vinyl groups creating a range of decorated branched polymers, with a wide scope for functionalisation and potential for application in the field of drug delivery. Synthesis of Phthalocyanine-centered water-soluble polymers Muxiu Li University of Warwick Copper phthalocyanine, first developed in the mid-1930s as a pigment, has a bright greenish-blue colour and is frequently used in dyes and paints. In this work, (copper)phthalocyaninecentered water-soluble polymers can be synthesized using different methods, in order to increase dispersion of copper phthalocyanine in the toothpaste and adhesion on the teeth surface, which can make teeth whiteness last longer. 101 P167 proceeding by chain extension of a macro-RAFT agent deposited on to the particle surface. Core-shell Colloidal particles P170 Andrew Edwards Thermally Reversible Crosslinked Polyesters University of Warwick Core-shell polymer latex particles with pendant acrylate functionality in the outer regions of the colloids were prepared using a two-step emulsion polymerisation approach in which monodisperse seed particles were decorated with a shell of poly(ethylene glycol) basic acrylate functionalized microgels. The morphology of these hybrid structures were studied. The coreshell particles were post-functionalized by thiol-ene click chemistry to create a library of interesting colloidal particles. P168 Christopher Summers Roger Day, Umit Makal and David M. Haddleton University of Warwick Furan functionalised diols have been synthesised using a phosphine mediated thiol-ene click reaction. These diols have been successfully incorporated into polyesters using a low temperature scandium triflate catalysed polycondensation route. The thermally reversible crosslinking of these polyesters in a Diels-Alder reaction with a bismaleimide has been proven by NMR, DSC and GPC studies. Responsive Hybrid Nanocomposite Particles for Controllable Metal-Enhanced Fluorescence Effects Dr Ning Ma Fu Tang, Jianfeng Zhang and Lidong Li University of Science and Technology Beijing The metal-enhanced fluorescence (MEF) effect is a phenomenon whereby fluorescent molecules in close proximity tunable metallic nanostructures (such as Ag, Au), display an increase in the fluorescence intensity. In this presentation, a series of hybrid fluorescent nanocomposite particles functionalized with Ag nanoparticles have been prepared for controlling the MEF effects to the fluorophores such as water-soluble polyfluorene derivatives (PFV) and porphyrin derivatives. For example, poly (N-isopropylacrylamide) (PNIPAM) can be employed as functional shells on the Ag nanoparticle cores to form Ag@PNIPAM nanoparticles and then PFV was assembled by electrostatic interaction. These functional hybrid nanoparticles with tunable MEF effects show a great potential application in the fields of responsive fluorescent sensing and detection. P169 P171 Cryopreservation of cells using peptidomimetic macromolecules. Robert Deller Matthew.I.Gibson University Of Warwick Ice recrystallisation during freeze/thawing of cells is a major contributor to cell damage during cryopreservation. Antifreeze(glyco) proteins (AFGPs) are a naturally occurring class of proteins found in cold-acclimatised species that have a simple polymeric structure that display a strong recrystallisation inhibition (RI) activity. We have developed several biocompatible peptidomimetic molecules that have comparable RI activity to AFGPs and demonstrated their effectiveness at cryopreserving red blood cells at 100x lower concentration than existing cryoprotectants. P172 Encapsulation of calcium carbonate particles within a polymeric shell Facile one-pot fabrication of anisotropic ‘Janus’ polymer colloid particles by bulk seeded emulsion polymerisation. Holly McKenzie dr. ir. Stefan Bon Thomas Skelhon Jack Dong, Stefan A. F. Bon University of Warwick University of Warwick Here we demonstrate two techniques in which we have encapsulated calcium carbonate particles in a polymeric shell. Firstly by precipitation polymerization, proceeding by the heterocoagulation of unstable particles on to the calcium carbonate surface. Secondly by RAFT emulsion polymerization Janus particles have unique properties that express multiple chemical functionalities in addition to their extraordinary morphology. As such, these particles have huge potential in chemical industry. However, bulk manufacture of janus particles with the properties that each application requires has restricted 102 their use in industry. This work presents the facile, large scale manufacture of polymeric janus particles on the nano and micron scale, with tuneable size, surface chemistry and morphology. P173 transitions in response to external stimuli. Sulfobetaine polymers are zwitterionic polymers that can respond to changes in temperature and salt concentration, dependant on their molecular weight and concentration. In this study, RAFT polymerisation has been utilised to synthesise well controlled sulfobetaine polymers and their aqueous solution behaviour is reported. Synthesis of hyperbranched, amphiphilic polymers by Catalytic Chain Transfer Polymerization P176 Jamie Godfrey David M. Haddleton Enzyme Mimics by RAFT Polymerisation University of Warwick Katherine Farrance Dr. R.K. O'Reilly Methacrylic acid and an ethylene glycol dimethacrylate crosslinker were polymerized in aqueous media by CoBF mediated catalytic chain transfer polymerization. The resulting branched polymers contain vinyl groups from chain transfer, as well as unreacted vinyl groups from the cross-linker, which can be functionalized by various strategies. The University of Warwick P174 Smart Microarray Platforms for Understanding Biochemical Interactions Caroline Moore Our group specialises in RAFT polymerisation, this enables the incorporation of monomers with a wide range of monomer units and the formation of a number of different structural scaffolds. This work aims to show how polymers synthesised by RAFT polymerisation are able to mimic well studied enzymes and show comparable activity with improved stability. P177 New Routes to Biodegradable Graft Copolymers Rebecca Williams Andrew P. Dove, Rachel K. O'Reilly University of Warwick University of Warwick Microarrays are used in conjunction with fluorescently-tagged protein targets to understand biological recognition process. Efforts are being made to interface microarrays with whole pathogenic organisms to probe adhesion and spreading mechanisms, aid candidate drug development and as diagnostic platforms. We present here recent developments into the synthesis of surface-functionalised microarrays on glass, silicon and gold, increasing their compatibility with various detection techniques (fluorescence, QCM, SPR). Polymeric tethers allow orthogonal immobilisation of various ligands, whilst providing exquisite control over surface features. P175 RAFT polymerisation of sulfobetaine monomers synthesis, characterisation and responsive behaviour Dr Helen Willcock Dr R.K.O'Reilly University of Warwick Much effort has been focussed on the synthesis of water soluble polymers that undergo conformational changes or phase Polycarbonates have gained increasing attention as materials for biomedical applications as a consequence of their biocompatibility, biodegradation and low toxicity. Advances in the synthesis of cyclic carbonate monomers have enabled the introduction of functionality along the polycarbonate backbone. We have prepared novel polycarbonates with multiple RAFT CTA functionalities and utilised these polymers to prepare welldefined graft copolymers with a biodegradable backbone. P178 Cylindrical micelles with a degradable core: understanding polylactides in self-assembly Nikos Petzetakis Andrew P. Dove Rachel K. O'Reilly University of Warwick Polylactides are hydrophobic polymers that have been long recognized as candidates for numerous applications due to their biodegradability, biocompatibility and tunable mechanical properties. Our recent work presents a number of different 103 concepts regarding micelles containing polylactides as the hydrophobic core. TEM, AFM, WAXD, SANS, fluorometry and light scattering were all applied to understand the behaviour of these assemblies. One of our latest findings is the use of crystallization as a tool to alter the self-assembly rules. The characterization of polylactide based morphologies in solution and in the bulk are discussed. P179 New conjugation methods for the synthesis of DNA block copolymers Tom Wilks P182 TBC Edward Malins, C. Remzi Becer University of Warwick TBC P183 DNA-templated synthesis Chrissie Bartlett-Waddington University of Warwick University of Warwick Previously, synthesis of amphiphilic DNA block copolymers (DBCs) has relied on the use of expensive solid phase DNA synthesis equipment. This work explores the use of different chemical methods for the formation of DBCs in organic solvents. The thiol-ene, copper catalysed azide alkyne cycloaddition, and tetrazine-norbornene inverse electron demand Diels-Alder (TzNb DAinv) ‘click’ reactions were all tested; of these, the Tz-Nb DAinv reaction was found to be the most reliable and efficient. Single stranded DNA has an affinity to hybridize with other complementary single strands of DNA. This property can be utilised to design artificial strands that hybridize, and then can be separated, in sequence. If functional groups are attached to the ends of the interacting strands: chemical reactions can be controlled, and a sequential chain of desired moieties can be produced. Advantages of this process are fine control of the end product and reactions able to occur under low molarities. P180 Cross-linking Polychloroprene P184 Keith Berry Dr. Paul Topham Polymer vesicles when they are exposed to colloidal particles Aston University Rong Chen TBC University of Warwick P181 Synthesis of anisotropic, silica-metal oxide, hybrid particles Alan Dawson Adam Morgan, Dr. ir. Stefan Bon Bon Polymer Colloids Group, University of Warwick Chemistry Department We investigate the behaviour of polymer vesicles when they are exposed to colloidal particles or organic hydrophobic small molecules. In the first case we show that armoured structures can be made, effectively providing the polymersomes with a layer of colloidal armour. In the second case we show that the bilayer under certain circumstances destabilises, leading to intricate more complex colloidal structures than simple bilayer based polymer vesicles Rodlike, silica-metal oxide colloidal particles were synthesised in a one-pot synthesis. These anistropic particles demonstrate a simple route to creating potential micron sized swimming particles. The use of silica over other metal based-systems is beneficial due to wide availability and low cost of reactants. Chemically the particles benefit from resistance to acid/base and show potential for a wide variety of surface functionalisations. 104 P185 P188 TBC Reactions at the polyethylene chain end Chris Waldron Christopher Kay The University of Warwick University of Warwick TBC TBC P186 Various cylindrical micelles prepared from polylactide– containing diblock copolymers based on the living crystallization–driven self-assembly P189 Polymer Peptide Conjugate for Hydrogels Arun Sohdi Paul D. Topham Aston University Liang Sun Department of Chemistry, University of Warwick Various cylinders were prepared based on crystallization-driven self-assembly. Cylinders were obtained by the self-assembly of poly (L-lactide)-b-poly (acylic acid) (PLLA-b-PAA) diblock copolymers with varying semi-crystalline poly (L-lactide) lengths, which were realized by the hydrolysis of poly (L-lactide)-b-poly (tetrahydropyran acrylate) (PLLA-b-PTHPA) diblock copolymers in tetrahydrofuran/water system. The synthesis of PLLA-bPTHPA combined the ring opening polymerization with radical addition-fragmentation chain transfer (RAFT) polymerization. Dynamic light scattering (DLS), transmission electron microscopy (TEM) and wide angle X-ray scattering (WAXS) were utilized to explore the different cylindrical micelles. The stereocomplex morphology of PLLA-b-PAA and PDLA-b-PAA were also studied. P187 The study on RAFT copolymerization of methacrylates containing nucleobase functionality Drug delivery is an essential area of medical science, allowing treatment or long term management of diseases such as cancer, HIV, and diabetes, and minimising the need for invasive surgery. Drugs are normally delivered orally via tablets or directly into the bloodstream via injection, and are dependent on patient compliance. Furthermore, levels of drugs in the body will depend on administration time, which can lead to either toxicity or lack of effectiveness. Development of new delivery methods uses natural peptides and polymers to form materials known as hydrogels. P190 TBC Silvia Amabilino Department of chemistry TBC P191 Yan Kang Department of Chemistry, University of Warwick Chemical polymers containing nucleobases can be prepared by the robust and broad convergence of synthetic and polymer chemistries. To the best of our knowledge, the majority of chemical polymers used in the previous polymerization studies are coded with a single type of nucleobase. Hence, we plan to expand the chemical polymers to incorporate multiple nucleobase functionalities and allow for access to a range of specific and sequential polymers. In our studies, RAFT copolymerization was used to make controlled copolymer containing nucleobases. Dr Ian Barker The University of Warwick TBC P192 A library of responsive polymers from a single scaffold Kay Doncom Dr R. K. O'Reilly University of Warwick 105 The aim of this work is to prepare a library of stimuli responsive polymers from a pentafluorophenyl acrylate-methyl acrylate diblock copolymer scaffold by utilising the reactivity of the activated ester towards a variety of primary amines. The stimuliresponse and resulting self- assembly behaviour of these copolymers has been studied. P193 Responsive materials to trigger cell membrane interactions Daniel Phillips Gibson, M. I. University of Warwick The application of stimuli-responsive polymers to triggering membrane and cellular interactions is an intriguing challenge in biochemical and macromolecular science. Our work focusses on the synthesis of protein-inspired polymeric materials containing functionalities capable of responding to biochemical signals. Here we will present new methodologies for incorporating redox-responsive, linkages for specific intracellular degradation, release of cargoes and as a switch to control lipophilicity. P194 The development of multifunctional, defined RAFT polymers for applications as supported acid scavengers biomimetic segregation/templating approach to synthetic radical polymerization. P196 Preparation of polytryptophan and the study of its interaction with 1'1-bi-2-napthol Beth Moore Rachel K. O'Reilly University of Warwick This poster will highlight the synthesis of a chiral monomer based on the amino acid tryptophan, the difficulty in polymerising this monomer directly by RAFT and the eventual synthesis of a controlled polymer of tryptophan for the first time using post-polymerisation functionalisation. This monomer and polymer was then studied in the presence of 1'1-bi-2-napthol (BINOL) and the interactions for L and D-tryptophan and R and SBINOL have been investigated. P197 Controlling the synthesis of polychlorprene - RAFT polymerisation Nikki Pullan and Dr. Paul D. Topham Aston University TBC Daniel Wright P198 University of Warwick The development of multifunctional, defined RAFT polymers for applications as supported acid scavengers P195 Biomimetic Radical Polymerization via Cooperative Assembly of Segregating Templates Dr Ronan McHale Joseph P. Patterson, Per B. Zetterlund, Rachel K. O'Reilly Warwick Segregation and templating approaches have been honed by billions of years of evolution to direct many complex biological processes. Nature uses segregation to improve biochemical control by organising reactants in defined, well-regulated environments, while transfer of genetic information is a primary function of templating. The ribosome, wherein messenger RNA is translated into polypeptides, combines both techniques to allow for ideal biopolymer synthesis. Herein will be presented a Synthesis of Macromolecules by DNA templated chemistry Dr Phillip Milnes Mireya McKee, Jonathan Bath, Eugen Stulz, Andrew Turberfield, Rachel O’Reilly Warwick University Using DNA templated chemistry we have prepared sequence defined decamers with tuneable functionality. This optimized DNA strand exchange mechanism allows for ready access to long oligomers synthesis in impressive overall yields and highlights the applicability of DNA-templated chemistries in the preparation of macromolecules with advanced properties. 106 P199 High internal phase emulsion gels with quadruple hydrogen bond functionality Yunhua Chen Nicholas Ballard, Stefan Bon The University of Warwick candidates for the introduction of a primary alcohol and amine functionality to the polymer via the methodology proposed. Thiol–ene click chemistry may be utilised to functionalise and cross-link unsaturated polyester obtained by enzymatic ROP of macrolactones. This approach therefore readily enables the highly efficient and chemically simplistic (bio)functionalisation of a aliphatic polyester and polyester films to yield significant products of potential biomedical importance. We demonstrate here a convenient route to organogels templated by high internal phase emulsions. Key is the use of a waterborne polymer latex loaded with a multiple hydrogen bond (MHB) functionality that becomes disentangled and transfers across the oil–water interface forming a gel network in the oil phase via hydrogen bond interactions. P200 Gabit Nurumbetov University of Warwick We demonstrate that by using a syringe needle, plastic tubing, two glass capillaries and epoxy glue a microfluidic device can be fabricated straightforwardly that allows for the production of double emulsions, or in other words the generation of dropletsin-droplets. The device in essence is a serial combination of droplet generation by co-flow and a T-junction. To reduce potential issues with channel wetting, we established that an “obstructed” T-junction outperformed a conventional Tjunction. We illustrate the versatility of our device through production of a range of polymer microcapsules, including ones that contain a waterborne dispersion of colour changing pigment, and microcapsules with compartmentalized ferrofluidic segments, that is capsules that contain more than one droplet of ferrofluid. P201 Functional Films from Unsaturated Polyesters from Macrolactones via Thiol-ene Click Chemistry Zeliha Ates Paul D. Thornton, Andreas Heise Dublin City University P202 Amphiphilic poly(4-vinylpyridine-b-methyl methacrylate) block copolymers for metal binding application Nurulsaidah Abdul Rahim Fabrice Audouin, Brendan Twamley, Johannes G. Vos, Andreas Heise School of Chemical Sciences, Dublin City University Controlled radical polymerisation (CRP) offers the ability to prepare a wide variety of well-defined polymer architectures. Here we reported well-defined poly(4-vinylpyridine)(P4VP) synthesized using BlocBuilder MAMA-SG1 at 110°C in NMP. These block copolymer spontaneously self-assemble in THF into spherical inverse micelles with critical micelle concentrations of 0.1 mg/mL for poly(4VP190-b-MMA91) and 0.01 mg/mL for poly(4VP190-b-(MMA57-co-S18)). The size of micelles measured by DLS was in the range of 70 to 130 nm depending on the block copolymer composition. P203 Biodegradable PolyHIPE's from Photo-‘Click’ Thiol-ene and Thiol-yne Chemistry Matthew Didsbury Dr David Ward Johnson, Elaine Lovelady, Sally Caldwell, Prof Stefan A. Przyborski, Prof Neil R. Cameron. Durham University Fast cure times (<5min) associated with photo-polymerisation allow consistent polyHIPEs to be produced from unstable HIPEs. Recently we have demonstrated that thiol-ene and thiol-yne photo-‘click’ chemistry, can produce polyHIPE materials. Surface chemistry can be altered by tuning the ratio of thiol to acrylate. Excess thiol groups can surface functionalize the polyHIPE via photo ‘clicking’ of acrylates. Thiol-ene polyHIPEs biodegrade in cell culture medium making them of interest. Cell culture requires tuning the mechanical and morphological properties of the scaffold. Aliphatic polyesters, prepared by ring opening polymerization (ROP) of lactones, posses good mechanical properties, biocompatibility and biodegradation. 6-Mercapto-1-hexanol (MH) and N-acetylcysteamine (nACA) were selected as suitable 107 P204 Generation of Giant Unilamellar Vesicles via Electroformation Method Artur Kubilis, Dr. Ahmed M. Eissa and Prof. Neil R. Cameron Durham University In the present work, we develop the electro-formation methodology for producing giant unilamellar vesicles from natural phospholipids and synthetic polymer amphiphiles. Correlation of various electro-formation factors with shape, size and distribution of vesicles is also investigated. 1,2-Dioleoyl-snglycero-3-phosphocholine (DOPC) was employed in this study as a model natural lipid. Within our group, we are developing different synthetic methodologies for preparing amphiphilic glycopolymers, synthetic polymers containing pendant carbohydrate units, which are currently being engaged in the electro-formation to produce polymersomes. The properties of the generated liposomes and polymersomes will be compared and studied in detail. hydrophobicity, differ to that of the bulk. In the case of polymers such as poly(styrene) and poly(isoprene), end-capping with fluoroalkyl groups derived from a novel perfluorinated initiator species can be introduced via controlled living anionic polymerisation As pCBT end-groups are supplied only by the titanate ligands during initiation, molecular weight control is dependent on the mol. % of initiator. Furthermore the polymerisation remains active at the propagating end. Addition of perfluorinated alcohol therefore provides a route to termination. We believe that endcapping takes place via an alcohol-ester exchange process, with transesterification adding a perfluorinated end-group that effectively terminates the propagation of the polymer chain. We intend to introduce isophthalic monomers to the reaction mixture in order to reduce the crystallinity and solvent resistance of the product polymer. We also wish to blend endcapped pCBT polymer with other polyesters to observe blend miscibility and assess whether surface migration of the perfluorinated end-groups occurs in a similar fashion to the studies mentioned previously. P207 P205 The Application of PolyHIPEs for 3D Hepatocyte Culture Sythesis and Self-Assembly of Block Copolypeptides from N-Carboxyanhydides Adam Hayward Alexander Groenen Sarah Hehir, Neil R. Cameron Durham University Durham University In vitro hepatocyte models are used in drug discovery for toxicity predictions. However, traditional models using 2D plastic substrates can lead to unrealistic cell architectures and jeopardise predictive accuracy. Alvetex is a commercial polyHIPE that has been developed as a scaffold for 3D cell culture. Here we show the application of alvetex to create a more representative 3D hepatocyte model towards improved predictive accuracy. We also discuss developments in novel galactose-functionalised alvetex for further improvements in hepatocyte in vitro function. Sythesis and Self-Assembly of Block Copolypeptides from NCarboxyanhydides P206 In-situ synthesis of end-functionalised aromatic polyester – the effect of perfluorinated groups on surface hydrophobicity Christopher D. James, Lian. R. Hutchings, Solomon M. Kimani, Richard. L. Thompson Durham University Much research has been conducted into functionalising polymers so that their surface properties, such as P208 "RAFT-Mediated Polymerizations in thermoresponsive Nanoreactors" Khaled Sebakhy The Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland Nanoreactors of poly(N-isopropylacrylamide-bdimethylacrylamide-Co-butylacrylate) were used with a 4-arm poly(N-isopropyl acrylamide) (PNIPAM) to synthesize for the first time 4-arm star polystyrene in water using reversible-addition fragmentation chain transfer (RAFT). The nanoreactors when heated above their LCST self-assemble forming self-stabilized nanoparticles which behave as the loci for the polymerization. This surfactant-free emulsion polymerization showed good control over molecular weights and particle size distributions. Polydispersity indexes for molecular weights were in most cases 108 below 1.30 indicating that star-star coupling reactions do not play a role or participate in the polymerization mechanism. Monomer conversions were very high reaching almost full conversions in a timely manner. The stability of the aqueous dispersion was also improved by increasing the concentration of the nanoreactor. The particle diameters increased with increasing conversion whereas the number of particles (Nc) were almost constant ranging from 1016-1017 particles/L showing that the polymerization mechanism resembles a typical emulsion polymerization. P209 Architectually complex branched block copolymers hyperblocks poly (caprolactone) were synthesized in one-step by simultaneous free radical polymerization of styrene (St) and ROP of caprolactone (CL) in the presence of the soluble polymeric oil macroperoxide. The principal parameters such as monomer concentration, initiator concentration, and polymerization time that affect the one-step polymerization reaction were evaluated. The polymers obtained were characterized by proton nuclear magnetic resonance (1H NMR), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), and gel permeation chromatography (GPC) techniques. Copolymerization kinetic was also evaluated. P211 Serena Agostini and Lian R. Hutchings Synthesis and Characterization of Thermoresponsive Graft Copolymers Containing Polymeric Linoleic Acid/Linolenic Acid Durham University Dr Abdulkadir Allý, Sema Allý and Baki Hazer We describe the synthesis of a new class of hyperbranched polymers named HyperBlocks. A single sample of HyperBlock has been studied in a previous work and it demonstrated the possibility of being a new class of branched thermoplastic elastomers. The HyperBlocks result from the coupling reaction of these macromonomers. The coupling has been done using two different methodologies: Williamson coupling reaction and azide-alkyne click reaction. The reactions demonstrated good conversion of the precursors in both methodologies. The second methodology was shown to be comparably faster and less sensitive to impurities. Characterisation of the solid state morphologies and mechanical properties of HyperBlocks is ongoing. University of Düzce P210 Synthesis and Characterization of Polystyrene-g-Poly (Linoleic Acid)-g-Poly (caprolactone) Graft Copolymers Sema Alli, Abdulkadir Alli and Baki Hazer University of Düzce One-step synthesis of graft copolymers by ring-opening polymerization (ROP) and free radical polymerization by using polymeric linoleic acid peroxide (PLina) is reported. PLina were obtained by the autoxidation of linoleic acid (Lina). The autoxidation of Lina under air at room temperature rendered waxy soluble polymeric peroxide, having a soluble fraction in chloroform of more than 91 wt% and containing up to 1.0 wt% of peroxide. The soluble polymeric oil macroperoxide was used to initiate the free radical polymerization of styrene (St) and ROP of -caprolactone (CL) resulting in PSt-g- PLina-g-PCL graft copolymers. The graft copolymers comprised polystyrene and Polymeric linoleic acid peroxide (PLina) and polymeric linolenic acid peroxide (PLinl) were obtained by the autoxidation of linoleic acid (Lina) and linolenic acid (Linl), respectively. The autoxidation of Lina and Linl under air at room temperature rendered waxy soluble polymeric peroxide, having a soluble fraction in chloroform of more than 91 wt% and containing up to 1.0 wt% of peroxide. The soluble polymeric oil macroperoxide was used to initiate the free radical polymerization of N-isopropylacrylamide, NIPAM, resulting in PLina-g-PNIPAM and PLinl-g-PNIPAM graft copolymers, respectively. The PNIPAM content of the graft copolymers was calculated using the elemental nitrogen analysis of graft copolymers. Thermal analysis, FT-IR, 1H NMR, and SEM techniques were used in the characterization of the products. The hydrophobic effect of the fatty acid macro peroxides on the thermal response rate of the graft copolymers was investigated by means of swelling-deswelling behaviors in response to temperature change. They have a thermoresponsive character and exhibit a volume phase transition at approximately 30 oC, which is 4 oC lower than that of pure PNIPAM. P212 Development of Optimized Autonomous Self-Healing Systems for Epoxy Materials Based on Maleimide Chemistry Stijn Billiet, Wim Van Camp, Xander K.D. Hillewaere, Hubert Rahier and Filip E. Du Prez Ghent University 109 Maleimide chemistry involving amines and thiols is presented and evaluated for the design of autonomous self-healing epoxy materials. The maleimide conjugation reaction with residual amines in the epoxy material ensures chemical bonding of the newly formed network with the original materials during crack healing, while in the crack plane, multifunctional thiols react with difunctional maleimides to fill the crack area. Healing efficiencies are evaluated using the tapered double cantilever beam (TDCB) test method with manual injection of the healing agents. P213 Towards smart materials based on oppositely charged triblock copolymers Lenny Voorhaar, Richard Hoogenboom P215 Synthesis of hyperbranched polymers via thiol-yne chemistry Sofie Wallyn, P. Espeel, R. Hoogenboom, F. Du Prez Ghent University The last years, more and more attention goes out to the synthesis of hyperbranched polymers because of their unique chemical and physical properties. The aim of this work is to synthesize and evaluate hyperbranched polymers via new routes by making use of the versatile and metal-free thiol-yne click reaction and the controlled radical polymerization technique RAFT. For the synthesis of the hyperbranched polymers, thiolyne click chemistry is used based on thiol-alkyne AB2 oligomers. These building blocks are synthesized via two strategies. Ghent University Oligomeric triblock copolymers with an uncharged middle block and charged outer blocks are synthesized via RAFT polymerization using a bifunctional chain transfer agent. The polymerization kinetics are studied in detail to optimize the preparation of well defined oligomeric triblock structures, eventually leading to polydispersity indices around 1.2. These triblock copolymers will be studied as basis for a range of smart materials, such as hydrogels, in which the electrostatic interaction between the charged blocks is envisioned to provide the material with adaptive properties. P214 Exploration of the reactivity of a thiolactone moiety in polymer synthesis and modification Dr Pieter Espeel, Fabienne Goethals, Milan M. Stamenovic, Lionel Petton, Filip E. Du Prez Ghent University The in situ generation of thiols by aminolysis of a thiolactone, followed by a UV-initiated radical thio-ene reaction in a one-pot fashion, has been evaluated as an accelerated and versatile protocol for the synthesis of functional, linear polymers and networks via a radical photopolymerization process. Narrow polydisperse poly(thiolactones) have been synthesized via controlled copolymerization of vinyl monomers with a thiolactone containing monomer. Subsequently, a double modular modification (aminolysis and thiol-X) yields welldefined, multi-functional polymers. P216 Tetrazine-Norbornene click reactions: applications in polymeric materials and assemblies Claire Hansell, Milan Stamenovi, Pieter Espeel, Ian A. Barker, Andrew Dove, Filip Du Prez, Rachel K. O'Reilly University of Warwick “Click” as a concept needs virtually no introduction, such is its prevalence across nearly all fields in chemistry. The inverse electron demand Diels-Alder reaction (DAinv) between tetrazines and strained alkenes (Figure 1) such as norbornene (Nb) has recently found application in chemical biology due to its fast reaction kinetics, high conversions and orthogonality to other functionalities, all criteria used when defining a click reaction. The advantages of this reaction over others are that it is irreversible, driven by the loss of nitrogen and requires no stimulus or catalyst (metal or otherwise), simplifying purification procedures considerably when compared to other methodologies. We have demonstrated that the inverse electron demand DielsAlder between tetrazine and norbornene is a viable method of polymer-polymer conjugation and functionalization. The reaction does not require the addition of any further reagent aside from the two functional polymers in equimolar amounts, or stimulus to proceed, is easily monitored using a distinctive colour change from purple to orange, and the coupled product needs no purification following the reaction. We have also used the orthogonality of the tetrazinenorbornene click reaction to the CuAAC click reaction to 110 orthogonally functionalise a single polymeric scaffold/nanostructure with two different moieties, in tandem. P217 (particle size, CMC, drug loading efficiency, and drug release profiles) were compared to their analogs formed by linear or star shaped amphiphilic block copolymers containing ecaprolactone units. P220 Enzyme responsive microgels Daniela Kalafatovic, Brian R. Saunders and Rein V. Ulijn Sortase A: A Molecular Stapler for use in Conjugation University of Strathclyde Thomas Waller The expression levels of enzymes dictate the difference between health and disease in many cases, including cancer. It is the objective of this work to develop an enzyme responsive system based on microgels as attractive starting point towards the control of such diseases. The current focus is on changing the peptide sequence, resulting in responsiveness to different enzymes. This is attractive prospect as it could result in a system applicable to any kind of enzyme, either in drug delivery or as diagnostic tool. A successful outcome of these systems and moving towards in vitro and in vivo testing is a chance to improve the potential for future applications in medicine. University of Surrey P218 Transition metal catalysts immobilised on block comicelles David Lunn, Paul G. Pringle and Ian Manners University of Bristol Block comicelles could potentially provide excellent supports to spatially isolate orthogonal catalysts and allow the preparation of new tandem catalytic systems. Polyferrocenylsilane based diblock copolymers undergo crystallisation-driven self-assembly in block selective solvents to form block comicelles. The use of a polymethylvinylsiloxane coblock allows us to phosphinefunctionalise the micelle coronas, coordinate transition metals and investigate the catalytic activity of these materials. P219 Preparation and characterization of nanoparticles containing indomethacin or quercetin. Katarzyna Bury, Filip Du Prez, Dorota Neugebauer Silesian University of Technology A series of CLMA based amphiphilic graft copolymers with different number and length of side chains were used in formation of nano-scale particles for drug delivery systems. As a model drugs Indomethacin and Quercetin were incorporated into hydrophobic core of nanoparticles. Properties of micelles Unmodified proteins have been used within medicine for a number of years. However, by joining these proteins to a large molecule like a polymer it is possible negates these problems by providing a secure anchor point and a shield for the protein to prevent degradation and increase availability. Modification of proteins has historically involved chemical reactions with amino acids. However, producing polymer-protein conjugates in this way results in a number of sites of modification on the protein, a loss of protein activity and undesired protein cross-linking. A new synthetic route employs an enzymatic methodology using S. aureus Sortase A enzyme to conjugate selectively to any protein containing a short sequence with amino acids to molecules that contains di-Gly amino group. This provides a general, robust, and gentle approach to the selectively immobilize of proteins onto a range materials. This is being investigated in the synthesis of protein-polymer conjugates containing GFP modified with diGly containing polymers of OEGMA. P221 Utilizing Polymer Topology for Unique Assembly and Responsive Behavior in Polypeptide-based Amphiphiles Jacob Ray, Sandeep S. Naik, Jack Ly, Daniel A. Savin The University of Southern Mississippi Stimuli-responsive copolymers demonstrate diverse aggregation behavior in aqueous solution. In general, the molecular architecture and the balance of hydrophilic and hydrophobic volumes influence morphology. This study involves polypeptidebased ABA and BAB linear triblock copolymer as well as AB2 star copolymer (structurally resemble phospholipids) amphiphiles. Model systems for this study are poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine)(PLys-b-PPO-b-PLys, abbreviated KPK) ABA triblocks, PPO-b-PLys-b-PPO (PKP) BAB triblocks, and poly(Lglutamate) (PE)-based star copolymers. Both KPK and PKP assemblies have demonstrated morphology transitions with pH, a behavior driven by the helix-coil transition of the polypeptide As a model study, doxorubicin (DOX), a chemotherapeutic, was loaded and released from certain polypeptide assembles; UV- 111 visible spectrometry was used to measure the percent encapsulation and release of DOX based on its peak absorbance at 483 nm. P222 Ultraselective Fluorescence Sensing of Mercury Ions over a Broad Concentration Range Based on Polymeric Micelles Jinming Hu, Tao Wu, Guoqing Zhang, Shiyong Liu University of Science & Technology of China We constructed a novel type of polymeric fluorescent Hg(II) ion probe covering a broad effective concentrations range from nM to mM levels and exhibiting excellent detection selectivity. It integrates two kinetically resolved fluorophore decaging reactions, namely, Hg(II)-induced ring- opening reaction of RhBHA residues and Hg(II)-catalyzed hydrolysis of caged HCMA moieties, and utilizes mixed diblock copolymer micelles as the scaffold. This sensing platform also allows for the fluorescent ratiometric sensing of Cu(II) ions. P223 Biocompatible, biodegradable Giant Amphiphiles Eleftheria Daskalaki, E.Daskalaki, K. Velonia Department of Chemistry, University of Crete The chimeric supramolecular assemblies which are designed to merge the catalytic and structural/functional properties of biomolecules, with those of polymers have been in the focus of research for more than three decades due to their increased application potential. We focused on the development of methods that would efficiently lead to well defined, amphiphilic protein-polymer conjugates with improved polydispersity and were able to synthesize libraries of such chimeric bioconjugates that assemble into well-defined superstructures. Herein, our efforts to lead this research to a conceptually new direction that of the “green”/enzymatic synthesis of polymer-protein amphiphiles comprising proteins with biocompatible and biodegradable polymeric tails will be discussed. We will focus on the synthesis, study of assembly and function of the resulting biodegradable chimeras and our endeavors toward the construction of the first self-constructing/self-destructing Giant Amphiphile nanocarriers. P224 “One Pot Synthesis of Clickable Polymers by Group Transfer Polymerisation” Dr Theoni Georgiou, Mark A. Ward and Theoni K. Georgiou University of Hull Propargyl methacrylate, PAMA was polymerised using a living polymerisation technique, specifically Group Transfer Polymerisation, GTP. For PAMA homopolymers the synthesis was successful to produce low MW polymers when the temperature was kept at around 15°C. When it was sequential copolymerized the synthesis was successful only when the PAMA added last. Simultaneous copolymerisation of the PAMA with poly(ethylene glycol) methacrylate, PEGMA produced a random copolymer with a narrow polydispersity (PDI=1.16). This PAMA-co-PEGMA was successfully clicked with 4-azido benzoic acid. Thus well-defined clickable polymers can be prepared using one pot GTP synthesis. P225 High Performance Solvent-Free Coatings Designed by RAFT Polymerization Marion Chenal, Jutta Rieger, Costantino Creton, Laurent Bouteiller University Pierre et Marie Curie - Laboratoire de Chimie des Polymères The development of latexes, i.e. colloidal dispersions of polymer particles in water, opened a new era in the field of coating . This study investigates the influence of nanostructuration on the mechanical properties of latex films. A controlled radical emulsion polymerization was performed without using surfactants in order to control the monomers incorporation during polymerization and obtain core-shell particles. In more details, a poly(acrylic acid) macro-RAFT agent was first synthesized in solution before being used in a second step in water to control the emulsion polymerization of butyl acrylate. Thus, the amphiphilic block copolymers synthesized in water (PAA-b-PAbu) self-assemble in situ to yield highly stable welldefined core-shell particles composed of a soft poly(butyl acrylate) core and a hard poly(acrylic acid) shell. After drying, a cohesive film is obtained. Elongational rheology measurements performed on the film indicate that the poly(acrylic acid) shell is responsible for a significant rise of the Young modulus, which can be explained both by hydrogen bonding between particle surfaces and by a 112 higher Tg in the interfacial region. These results show that the nanostructuration of the films clearly improves their macroscopic mechanical properties. P226 Synthesis of well controlled polyacrylates containing hydrogen bonding moieties for adhesion The temperature-responsive behavior makes oligo(ethylene glycol)-grafted polymers potentially useful tools for a variety of applications including bio(nano)technological applications, (e.g. bioconjugates and biosensors). Considering this, we have investigated the effect of end-group modifications on the phase transition temperature of the random copolymers of diethyleneglycol methacrylate and oligoethyleneglycol methacrylate, synthesized by reversible-addition fragmentation chain transfer polymerization. Cécile Fonteneau, Xavier Callies, Cyril Vechambre, Guylaine Ducouret, Constantino Creton, Jean Marc Chenal, Laurent Chazeau, Sandrine Pensec, Laurent Bouteiller P229 Dextran-graft-poly(ethylene imine) for Gene Delivery – Structure-activity Relationships Laboratoire de chimie des Polymères Low Tg polymers incorporating hydrogen bonding moieties in the chain has shown some interesting adhesive properties on steel and silicone surfaces. In this context, we have synthesized controlled polyacrylates via ATRP from urea containing initiator. We have demonstrated the influence of the strength of the hydrogen bonding groups and of the length of the polymer on the self-assembled structure in bulk and the rheological and adhesive properties. P227 Iron-containing Heteroarm Star Polymers for use in Nanolithography Antje Vollrath, S. Ochrimenko, K. Kempe, L. Tauhardt, S. Schubert, D. Fischer, U. S. Schubert Organische Chemie Friedrich-Schiller-Universität Jena Linear poly(ethylene imine), which was synthesized by acidic hydrolysis of poly(2-ethyl-2-oxazoline), was grafted onto dextran from Leuconostoc mesenteroides (M = 60,000 g/mol) by different synthetic routes. In order to determine structureactivity relationships of the dextran-graft-PEIs, the linker unit, the molar mass of the LPEI, as well as the degree of substitution were varied. DNA binding capacities and the transfection efficiency of the dextran modifications were analyzed. P230 Adam Nunns, Dr. Hong Choi, Prof. Ian Manners, Prof. Caroline Ross Poly(2-Alkyl-Oxazolines) of different Architecture via Macromolecular Conjugation Reactions University of Bristol The influence of block lengths on the solid-state self-assembly of ABC star polymers has been investigated. A range of Star (polystyrene-polyisoprene-poly(ferrocenylsilane)) terpolymers have been prepared via a “core-first” route, utilising copper(I) catalysed azide-alkyne cycloaddition reactions, and a chlorosilane route. Bulk- and thin-film self-assembly experiments of these materials has enabled the elucidation of their morphologies, which have demonstrated a diverse range, from lamellae with alternating beads at the interface, to novel Archimedean tiling patterns. P228 Effect of end group modification on phase transition of oligo(ethylene glycol)-grafted polymers Tobias Rudolph, Kristian Kempe, Ulrich S. Schubert, Felix H. Schacher Friedrich-Schiller-University Jena We describe the synthesis of functionalized poly(2-alkyloxazolines) of different architecture via living cationic ringopening polymerization, followed by macromolecular conjugation reactions of thiol-ene or azide-alkyne type. In that way, linear, star-shaped, and cyclic block copolymers of different composition are formed. The solution self-assembly in response to external stimuli like temperature or the actual solvent mixture was investigated using light-scattering (DLS) and electron microscopic techniques (TEM, cryo-TEM). Ekrem Ozer, Volga BULMUS Izmir Institute of Technology 113 P231 Dehydroalanine-based Nanoparticles via Miniemulsion Polymerization core and the shell of the microgels was investigated as a function of the degree of ionization of the ionizable monomer repeat units. The complex uptake and release profiles of small ionic molecules from the core and the shell of the microgels was studied by UV/vis spectroscopy. Ulrike Freier, Michael Böhme, Felix H. Schacher P234 Friedrich-Schiller-University Jena We present the synthesis and characterization of polymer nanoparticles via miniemulsion polymerization of methyl-2((tert-butoxycarbonyl)amino)acrylate (Dehydroalanine) in water. Stable emulsions with particles in the range of Rh = 20 - 40 nm were obtained, modified by polymer-analogue reactions and characterized using light-scattering (DLS) and electron microscopic techniques (TEM, cryo-TEM). P232 Photochemical modular strategies for modification of various polymeric substrates and surfaces Dr Guillaume Delaittre, Thomas Pauloehrl, Mathias Dietrich, Michael Bruns, James P. Blinco, Martin Bastmeyer, Christopher Barner-Kowollik KIT (Karlsruhe Institute of Technology) - Preparative Macromolecular Chemistry To gain temporal and spatial control over materials functionalization, we present a range of phototriggered modular ligations which we applied to polymeric chains in solution as well as on (bio)surfaces: i) photocleavage of o-nitrobenzylthioether and subsequent Michael addition, ii) photocleavage of onitroveratrylacetal for further oxime ligation, iii) photolysis of diaryl tetrazoles yielding nitrile imines reactive in 1,3-dipolar cycloadditions, iv) photoisomerization of o-methylphenyl aldehydes and ketones and subsequent Diels-Alder [4+2] cycloadditions, and v) photolysis of a radical initiator followed by nitroxide-mediated radical trapping. P233 Microgel Nano-Colloid Dispersions of Core-Shell Topology Fanourios Krasanakis, Christodoulakis K. E., Vamvakaki M. University of Crete, Chemistry Dept. pH-responsive microgels of core-shell topology comprising basic and acidic monomer repeat units were synthesized following a two step emulsion polymerization process. The colloids were characterized by dynamic light scattering, scanning and transmission electron microscopy. The swelling behavior of the Synthesis and Characterization of Janus Nanoparticles Panagiotis Falireas and Moatsou D, Vamvakaki M University Of Crete We report the synthesis of Janus nanoparticles comprising an inorganic core and polymeric chains which are selectively grafted from one part of the particle surface. First, initiator functionalized Janus particles (D = 100 nm) have been synthesized via a pickering emulsion approach. Next, ATRP was used to grow well defined polymer chains from the nanoparticles’ surface. The Janus character of the particles was confirmed by scanning and transmission electron microscopy whereas, dynamic light scattering was used to investigate the solution properties of the anisotropic particles. P235 Merrifield Resin Appended Calixarenes for Adsorption of p-Nitrophenol from Aqueous Solutions Farabi Temel, Begum Tabakci, Mustafa Tabakci, Vahti Aladagli Selcuk University Organic compound pollution has become a major concern in the production of safe drinking water and in many countries there are strict regulations that limit the concentration of these compounds. According to our knowledge, there are no studies with calixarenes as adsorbent though various studies have been carried out about adsorption of the p-nitrophenol in the literature. Thus we have prepared Merrifield resin appended calixarenes containing different functional groups and investigated their adsorption properties for p-nitrophenol in this work. P236 Immobilized Calixarenes onto Silica Support for Adsorption of Phenolic Substances from Aqueous Solutions Professor Mustafa Tabakci, Farabi Temel, Begum Tabakci, Gulsevil Gok Selcuk University 114 Phenol is one of the most frequent contaminants in industrial waste and potable water. It is highly toxic, corrosive, and narcotic. Removal of phenol and phenolic compounds from industrial waste and potable water seems to be very essential. In our previous works, we have also synthesized several polymeric calixarenes and it has been investigated their extraction or adsorption properties for ions and neutral molecules. On the other hand, various studies have been carried out about adsorption of the phenolic substances, but there are no studies with calixarenes as adsorbent in this regard according to our knowledge. Thus we performed immobilization of several calixarenes containing different functional groups onto silica support and investigated adsorption properties for phenolic substances. P237 Switching the Morphology of Micellar Nanoparticles with Enzymes Ti-Hsuan Ku and Nathan Gianneschi University of California, San Diego In biology, stimuli-responsive multisubunit assemblies are ubiquitous, and mimicking these systems via synthetic approaches is of increasing interest. Interfacing such synthetic materials with biological systems is particularly promising for a range of biomedical applications including targeted drug delivery and molecular diagnostics. Within this class of materials are particles capable of changing morphology in response to stimuli. Enzymes are attractive and unique stimuli with great potential in this regard, as they propagate an amplified response via catalytic reactions, can be highly substrate specific, and have expression patterns sometimes associated with disease states. Nanoscale assemblies of block copolymer amphiphiles are well-suited for the development of functional, stimuli-responsive systems because changes in the chemical or physical nature of the amphiphile can lead to formation, destruction, or morphological transformations. Herein, we describe a range of enzymatic switches of micellar morphology utilizing peptide polymeric nanoparticles. P238 Programming Nanoparticles with DNA, Peptides and Enzymes Miao-Ping Chien, Nathan Gianneschi biomolecular stimuli are expected to have broad utility in a range of settings including targeted drug delivery, pharmacokinetic control, metal templation and detection or diagnosis strategies. Herein, we describe several strategies developed to incorporate nucleic acids, peptides, proteins, and enzymes into novel polymeric synthetic materials with the aim of programming morphology and function. Enzyme-responsive peptide polymeric nanoparticle systems, with fluorogenic labels will be described together with nucleic acid based materials capable of undergoing tunable changes in circulation and accumulation in vivo. P239 Synthesis of non-natural amino acids and their polymerisation Ms Dafni Moatsou and Rachel K. O'Reilly University of Warwick The synthesis of amino acids containing novel non-natural functionalities is drawing attention due to the higher order architectures and possible technological applications that arise from the incorporation of such amino acids into polypeptides. This work focuses on the synthesis of norbornene-functional amino acids and their polymerisation by N-carboxyanhydride ring opening polymerisation (NCA ROP), as well as the study of the properties of the resulting materials. P240 Catechol terminated polymers as an adhesion promoter for non-stick coatings Mr Andrew Ross University of Warwick Inspired by the adhesion of mussels, much effort has been directed to characterising and mimicking these properties. The adhesive proteins have been found to contain high levels of DOPA, a catecholamine. This catechol functionality provides adhesion through coordination of 1,2-hydroxyl groups to a surface. By functionalising polymer chains with catechol containing groups a primer layer for high temperature cured coatings can be formulated. This would allow adhesion of the coating to naked steel which oxidises at high temperature curing o (>320 C) causing conventional adhesion to fail. University of California, San Diego Nanoscale particles programmed to undergo dramatic, reversible and defined changes in morphology in response to 115 P241 P243 Single-Chain Nanoparticles Driven by Enamine Formation Chemistry Discovering new polymeric colloidal stabilisers for liquid crystalline nanostructured drug delivery particles Ana Sanchez-Sanchez, José A. Pomposo and David Fulton Boyd, Ben J. Chong, Josephine Y. T. ; Mulet, Xavier ; 2 Drummond, Calum J. ; Centro de Física de Materiales (CSIC, UPV/EHU) 1, 1,2 1,2 1 Single-chain polymeric nanoparticles are emerging soft nano-objects showing dimensions below 10 nm displaying promising properties for different end-use applications such as processing additives, blend compatibilizers, artificial enzymes, photostable bio-imaging agents and drug/siRNA-delivery systems. Significant efforts have been devoted in recent years to open new routes to unimolecular nanoparticles relying on efficient synthetic methods for the efficient intrachain crosslinking of individual polymer chains. In this work we focused on the construction of single-chain nanoparticles by metal-free enamine formation chemistry in organic solvents starting with alkyl diamines and appropriate precursor polymers containing beta-ketoester units. Monash Institute of Pharmaceutical Science, Monash University, 2 Parkville, Australia ; CSIRO Materials Science & Engineering, Clayton, Australia Complex internally structured lipid particles, such as cubosomes and hexosomes, are increasingly of interest for drug delivery. We have applied high throughput synthetic and evaluation techniques to synthesise a range of amphiphilic brush copolymers to rapidly determine essential features for steric stabilization of cubosomes. Varying PEG length and the hydrophobic anchoring group yielded a range of polymers of varying structure and function as effective stabilisers in these systems. P244 P242 Bespoke PMMA Nanoparticles Designed via Radical Dispersion Polymerization in Non-Polar Solvent: Size and Polydispersity Control Dr Alexandre Richez Designer stabilisers for multifunctional drug and imaging delivery vehicles 1 1,2 1,2 Boyd, Ben J. Chong, Josephine Y. T. ; Mulet, Xavier ; 2 Drummond, Calum J. ; 1 University of Leeds Typically used in polar solvents, radical dispersion polymerizations in non-polar media are much less common. Herein, we present a systematic one pot synthesis to prepare well-controlled PMMA latex nanoparticles using dispersion polymerization in a non-polar solvent. Crucial parameters to control particle properties are explored. Particle size and polydispersity are studied by SEM. Radical dispersion polymerizations in non-polar solvents have recently been revisited due to their potential application to prepare particles for use in emerging display technologies. Herein, we study the effect of different crucial parameters on the size and polydispersity of PMMA latex particle using this polymerization method. Radical dispersion polymerization is performed in dodecane using a stabilizer, MMA, initiator and a chain transfer agent. After reaction, the colloidal dispersions are purified and characterized.Our studies revealed that changing concentration and ratios of materials allows tuning the final size of the PMMA latex particles. Effects of the monomer, stabilizer and charge transfer agent on particle diameter are presented. Herein, we showed that it was possible via dispersion polymerization in non-polar solvent to design particles with narrow polydispersity and chosen size. Monash Institute of Pharmaceutical Science, Monash University, 2 Parkville, Australia; CSIRO Materials Science & Engineering, Clayton, Australia We previously determined the optimal structural parameters for polymeric stabilisers for nanostructured liquid crystalline particles, cubosomes, using a high throughput approach. The structure-function ‘lessons’ have been applied to design highly effective amphiphilic co-polymers using RAFT to enable the preparation of monodisperse bio-functionalised steric stabilisers that will impart function to cubosomes as cellular targeting agents in drug delivery and bioimaging applications. That’s all folks 116 Delegate List Ms Nurulsaidah Abdul Rahim Mr Carlos Abreu Dr Dave Adams Mr Kevin Adlington Ms Serena Agostini Ms Miren Aguirre Professor Takuzo Aida Ms Busra Aksoy Mr William Alexander Professor Cameron Alexander Ms Sema Allý; Dr Abdulkadir Allý Ms Silvia Amabilino Ms Athina Anastasaki Dr Kevin Anderson Professor Steven Armes Professor José M Asua Ms Zeliha Ates Mr Kin Man Au Dr Neil Ayres Ms Clare Michelle Bakewell Mr Nicholas Ballard Mr Kuldeep Bansal Ms Inês Barata Dr Raphael Barbey Dr Ian Barker Professor Christopher Barner-Kowollik Ms Bianca Barros Mr Michael Barrow Mrs Chrissie Bartlett-Waddington Mr Simon Bassett Mr Johan Sebastian Basuki Dr Roz Baudry Dr Remzi Becer Professor Matthew Becker Mr Steve Bedder Dr Melania Bednarek Dr Jonathan Behrendt Dr Mariana Beija Dr Vasilios Bellas Ms Kate Belsey Mr Michael Bennison Mr Keith Berry Ms Eva Betthausen Dr Raj Bhardwaj Professor Christopher Bielawski Mr Stijn Billiet Professor Laurent Billon Dr Matthew Bird Ms Eva Blasco Dr James Blinco Ms Bianca Blunden Mr Tushar Borase Professor Steven Bottle Dr Elodie Bourgeat-Lami Dr Didier Bourissou Dr Ben Boyd Dr Cyrille Boyer Ms Victoria Boyes Mr Ruairi Brannigan Dr Daniel Bratton Professor Steve Brocchini Mr Paul Brooks Mrs Magali Bousquie School of Chemical Sciences, Dublin City University University of Coimbra University of Liverpool University of Nottingham Durham University Polymat/ University of the Basque Country UPV/EHU The University of Tokyo Inonu University University of Nottingham University of Nottingham University of Düzce University of Düzce Department of chemistry University of Warwick The University of Minnesota University of Sheffield POLYMAT, University of the Basque Country Dublin City University The University of Sheffield University of Cincinnati Imperial College London University of Warwick The University of Nottingham University of Coimbra Key Centre for Polymers & Colloids - University of Sydney The University of Warwick Karlsruhe Institute of Technology (KIT) University of Coimbra University of Liverpool University of Warwick University of Nottingham Australian Centre for Nanomedicine, UNSW Hydra Polymers Ltd University of Warwick The University of Akron Vertellus Biomaterials Limited Center of Molecular and Macromolecular Studies, PAS The University of Manchester CAMD - UNSW University of Bristol University of Kent University of Warwick Aston University University of Bayreuth Agilent Technologies UK td University of Texas at Austin Ghent University IPREM EPCP PolyTherics Ltd Universidad de Zaragoza-CSIC Queensland University of Technology University of New South Wales Dublin City University Queensland University of Technology CPE Lyon - Laboratoire de Chimie University of Toulouse Monash Institute of Pharmaceutical Science CAMD, The University of New South Wales Materials and Engineering Research Institute University of Warwick Illumina UCL School of Pharmacy and PolyTherics Department of Chemistry, Durham University MFP Michelin nurulsaidah.abdulrahim2@mail.dcu.ie carlosbreu@gmail.com d.j.adams@liverpool.ac.uk pcxka@nottingham.ac.uk serena.agostini@durham.ac.uk miren.aguirre@ehu.es aida@macro.t.u-tokyo.ac.jp mbusraaksoy@gmail.com pcxwha@nottingham.ac.uk cameron.alexander@nottingham.ac.uk semaalli@gmail.com abdulkadiralli@duzce.edu.tr s.amabilino@warwick.ac.uk A.Anastasaki@warwick.ac.uk bkanders@umn.edu s.p.armes@sheffield.ac.uk jm.asua@ehu.es zeliha.ates2@mail.dcu.ie K.M.Au@shef.ac.uk ayresni@ucmail.uc.edu c.bakewell10@imperial.ac.uk n.ballard@warwick.ac.uk paxkkb@nottingham.ac.uk inesbarat@hotmail.com r.barbey@chem.usyd.edu.au I.A.Barker@warwick.ac.uk christopher.barner-kowollik@kit.edu biancabarros@msn.com m.barrow@liv.ac.uk c.s.r.waddington@warwick.ac.uk pcxsb2@nottingham.ac.uk johan.basuki@student.unsw.edu.au ruth.jones@hydrapolymers.com c.r.becer@warwick.ac.uk becker@uakron.edu sbedder@vertellus.com bednarek@cbmm.lodz.pl anna.chan@manchester.ac.uk m.beija@unsw.edu.au vbellas@yahoo.com kb357@kent.ac.uk m.j.bennison@warwick.ac.uk Berryki@aston.ac.uk eva.betthausen@uni-bayreuth.de raj.bhardwaj@agilent.com bielawski@cm.utexas.edu stijn.billiet@ugent.be laurent.billon@univ-pau.fr matthew.bird@polytherics.com eblasco@unizar.es j.blinco@qut.edu.au bianca@student.unsw.edu.au tusharborase123@gmail.com s.bottle@qut.edu.au bourgeat@lcpp.cpe.fr dbouriss@chimie.ups-tlse.fr Ben.Boyd@monash.edu cboyer@unsw.edu.au vlboyes@my.shu.ac.uk R.Brannigan@warwick.ac.uk dbratton@illumina.com steve.brocchini@pharmacy.ac.uk p.p.brooks@durham.ac.uk magali.bousquie@fr.michelin.com 117 Mr Carl Bruce Dr Nico Bruns Professor Volga Bulmus Dr James Burns Ms Katarzyna Bury Mr Sean Butterworth Professor Neil Cameron Mr Benjamin CANNICCIONI Mr Davide Caramelli Mr Pedro Cardoso Mr Andrés Fernando Cardoza Perez Ms Linn Carlsson Dr Kim Carmichael Mr Farai Carter Professor Frank Caruso Ms Anabela Carvalho Ms Solene Cauet Ms Ana Maria Cenacchi Pereira Mrs Virginie CHABROL Mrs Isabelle Chaduc Professor Bernadette Charleux Ms Menglu Chen Mr Rong Chen Professor Gaojian Chen Dr Guosong Chen Mr Yunhua Chen Ms Marion Chenal Professor Wenlong Cheng Ms Miao-Ping Chien Ms Gwen Chimonides Professor Saad Uddin Choudhury Dr Jorge Coelho Mr David Cole Mr Oliver Coleman Dr Olivier Colombani Dr Patrick Colver Mr Tom Congdon Professor Andrew Cooper Ms Rosemeyre Cordeiro Mrs Pepa Cotanda Dr olivier coutelier Mr John Cowart Mr John Cowart Mr David Cressey Dr Hilary Crichton Ms Joana Crisóstomo Silva Dr Franck D'Agosto Dr Maarten Danial Ms Eleftheria Daskalaki Dr Anders Egede Daugaard Dr Liz Davies Professor Thomas Davis Mr Alan Dawson Dr Bruno De Geest Dr Peter Deakin Dr Jesus del Barrio Dr Guillaume Delaittre Mr Robert Deller Professor A. Levent Demirel Professor Joseph DeSimone Dr Christina Despotopoulou Professor Mathias Destarac Mr Matthew Didsbury Dr Anne-Cecile Dingwall Professor Dennis Discher Mr Cedric Dommanget Ms Kay Doncom Ms Charlotte Drappier Professor Eric Drockenmuller KTH Royal Institute of Technology University of Basel, Department of Chemistry Izmir Institute of Technology University of Warwick Silesian University of Technology School of chemistry, University of Manchester Durham University Université Montpellier 2 Warwick University University of Coimbra Laboratoire de Chimie de Coordination KTH Royal Institute of Technology, Croda University of Surrey The University of Melbourne Chemical Engineering Departement University of Liverpool CPE Lyon - Laboratoire de Chimie C2P2-LCPP CNRS - C2P2 University Claude Bernard Lyon 1 University of Warwick University of Warwick Soochow University Fudan University The University of Warwick University Pierre et Marie Curie Monash University University of California, San Diego Aston University Cotton College State University University of Coimbra Durham University University of Warwick PRES LUNAM, Université du Maine Croda Europe Ltd University of Warwick University of Liverpool University of Coimbra University of Warwick Université Paul Sabatier University of California at Santa Barbara University of California at Santa Barbara Lubrizol Ltd Journal of Applied Polymer Science University of Coimbra, Chemical Engineering Department CNRS UMR 5265 C2P2 LCPP Team University of Sydney Department of Chemistry, University of Crete Technical University of Denmark Royal Society of Chemistry University of New South Wales University of Warwick Chemistry Department Ghent University Sigma-Aldrich Co Ltd University of Cambridge KIT (Karlsruhe Institute of Technology) University Of Warwick Koç University University of North Carolina at Chapel Hill Henkel Ireland Limited University Paul Sabatier, Toulouse III Durham University Illumina Univ. Pennsylvania Equipe Chimie et Procédés de Polymérisation (LCPP) University of Warwick Lab. de Chimie des Polymères Organiques UMR5629 Uuniversity of Lyon cbruce@kth.se nico.bruns@unibas.ch volgabulmus@iyte.edu.tr j.a.burns@warwick.ac.uk katarzyna.bury@polsl.pl sean.butterworth@postgrad.manchester.ac.uk n.r.cameron@durham.ac.uk benjamin.canniccioni@univ-montp2.fr d.caramelli@warwick.ac.uk pedromlcardoso@hotmail.com andres.cardozo@lcc-toulouse.fr linnca@kth.se Kim.Carmichael@croda.com f.carter@surrey.ac.uk fcaruso@unimelb.edu.au annabelacarvalho@gmail.com s.cauet@liverpool.ac.uk ana.cenacchi@lcpp.cpe.fr virginie.chabrol@lcpp.cpe.fr chaduc@lcpp.cpe.fr charleux@lcpp.cpe.fr msplaf@warwick.ac.uk rong.chen@warwick.ac.uk gchen@suda.edu.cn guosong@fudan.edu.cn yunhua.chen@warwick.ac.uk marion.chenal@gmail.com wenlong.cheng@monash.edu m1chien@ucsd.edu chimongf@aston.ac.uk succcg@hotmail.com jcoelho3@gmail.com d.p.cole@durham.ac.uk o.coleman@warwick.ac.uk olivier.colombani@univ-lemans.fr Patrick.Colver@Croda.com t.r.congdon@warwick.ac.uk aicooper@liv.ac.uk rose@eq.uc.pt m.j.cotanda-santapau@warwick.ac.uk coutelier@chimie.ups-tlse.fr jcowart@chem.ucsb.edu jcowart@chem.ucsb.edu dave.cressey@lubrizol.com hcrichton@wiley.com joanacrisostomo@hotmail.com dagosto@lcpp.cpe.fr maarten.danial@sydney.edu.au d_omi_no@hotmail.com adt@kt.dtu.dk daviesea@rsc.org t.davis@unsw.edu.au Alan.Dawson@warwick.ac.uk br.degeest@ugent.be peter.deakin@sial.com jd529@cam.ac.uk guillaume.delaittre@kit.edu r.c.deller@warwick.ac.uk ldemirel@ku.edu.tr desimone@unc.edu christina.despotopoulou@henkel.com destarac@chimie.ups-tlse.fr m.p.didsbury@durham.ac.uk amortamet@illumina.com discher@seas.upenn.edu cedric.dommanget@cpe.fr K.E.B.Doncom@warwick.ac.uk cdrappier@enscbp.fr eric.drockenmuller@univ-lyon1.fr 118 Professor Jianzhong Du Professor Filip Du Prez Professor Philippe Dubois Ms Aroa Duro Castaño Mr Christoph Dürr Ms Elizabeth Eaves Dr Steve Edmondson Mr Andrew Edwards Dr Ahmed Eissa Dr Sarah Elliott Professor Todd Emrick Dr Richard Mark England Professor Thomas Epps Dr Francesca Ercole Dr Harikrishna Erothu Mr Panagiotis Falireas Mr Robert Farley Ms Katherine Farrance Dr Francisco Fernandez-Trillo Ms Maréva Fevre Mr Lee Fielding Dr Paul Findlay Mrs Ana Fonseca Ms Cécile Fonteneau Dr Brett Fors Prof John Forsythe Ms Nora Francini Professor Jean Frechet Ms Ulrike Freier Dr David Fulton Dr Ekaterina Gasilova Dr Julien Gautrot Dr Florence Gayet Professor Gill Garnier Dr Theoni Georgiou Professor Nathan Gianneschi Ms Anna Maria Giordano Mr Jamie Godfrey Dr Guillaume Gody Professor Jean-François Gohy Mrs Joana Rita Góis Dr Anja Goldmann Dr Verena Gortz Mr Edward Greenhalgh Dr Anthony Grice Mr Alexander Groenen Professor Jürgen Groll Mr David Growney Professor Robert B Grubbs Professor Sophie Guillaume Ms Gesine Gunkel Ms Shoghik Hakobyan Professor Ian Hamley Ms Claire Hansell Ms Susanne Hansson Ms Rachel Harbron Dr Robin Harrison Professor Eva Harth Ms Noor Aniza Harun Ms Amanda Harvey Professor Craig Hawker Mr Adam Hayward Professor Ryan Hayward Dr Sarah Hehir Dr Andreas Heise Dr Brett Helms Dr Hans Heuts Professor Marc Hillmyer Mr Hien The Ho Tongji University Ghent University University of Mons - UMONS Centro de Investigación Príncipe Felipe Karlsruhe Institute of Technology University of Manchester Department of Materials, Loughborough University University of Warwick Durham University Bruker UK Ltd University of Massachusetts Centro de Investigacion Principe Felipe University of Delaware Monash University Aston University University Of Crete University of Manchester The University of Warwick School of Pharmacy, University of Nottingham LCPO The University of Sheffield Hydra Polymers Ltd Chemical Engineering Department, University of Coimbra Laboratoire de chimie des Polymères University of California Monash University The University of Nottingham King Abdullah University of Science and Technology) Friedrich-Schiller-University Jena Newcastle University Russian Academy of Sciences Queen Mary University of London Laboratoire de Chimie de Coordination Monash University University of Hull University of California, San Diego Medway School of Pharmacy University of Warwick Key Centre for Polymers & Colloids Catholic University of Louvain University of Coimbra Karlsruhe Institute of Technology (KIT) University Of York University of Nottingham Warwick University Durham University University of Würzburg University Of Sheffield Stony Brook University Université de Rennes 1 - UMR 6226 University of Cambridge Umeå University University of Reading University of Warwick KTH Royal Institute of Technology Imperial College London Synthomer Vanderbilt University Newcastle University University of Sheffield Materials Research Laboratory Durham University University of Massachusetts Amherst Durham University Dublin City University (DCU) The Molecular Foundry - Lawrence Berkeley Nat. Lab. Eindhoven University of Technology University of Minnesota Université du Maine jzdu@tongji.edu.cn filip.duprez@ugent.be philippe.dubois@umons.ac.be Aroa.Duro@gmail.com christoph.duerr@kit.edu elizabeth.eaves@postgrad.manchester.ac.uk s.edmondson@lboro.ac.uk Andrew.R.Edwards@warwick.ac.uk a.m.eissa@durham.ac.uk sarah.elliott@bruker.co.uk todd.emrick@gmail.com rengland@cipf.es thepps@udel.edu francesca.ercole@monash.edu h.erothu@aston.ac.uk pfalir@iesl.forth.gr robert.farley@student.manchester.ac.uk msrlbd@warwick.ac.uk francisco.fernandez-trillo@nottingham.ac.uk fevre@enscbp.fr l.a.fielding@shef.ac.uk ruth.jones@hydrapolymers.com ana.clo.fonseca@gmail.com cecile.fonteneau@upmc.fr fors@mrl.ucsb.edu john.forsythe@monash.edu paxnf@nottingham.ac.uk frechet1@gmail.com ulrike.freier@uni-jena.de d.a.fulton@ncl.ac.uk Katja.Gasilova@gmail.com j.gautrot@qmul.ac.uk florence.gayet@ensiacet.fr gil.garnier@monash.edu t.georgiou@hull.ac.uk ngianneschi@ucsd.edu amg31@kent.ac.uk jamie.godfrey@warwick.ac.uk gody_g@chem.usyd.edu.au Jean-francois.gohy@uclouvain.be joanagois@gmail.com anja.goldmann@kit.edu verena.gortz@york.ac.uk pcxeg3@nottingham.ac.uk a.j.grice@warwick.ac.uk a.j.j.groenen@durham.ac.uk juergen.groll@fmz.uni-wuerzburg.de d.growney@sheffield.ac.uk robert.grubbs@stonybrook.edu sophie.guillaume@univ-rennes1.fr gg318@cam.ac.uk shoghik.hakobyan@chem.umu.se I.W.Hamley@reading.ac.uk C.F.Hansell@warwick.ac.uk sushan@kth.se rlh10@imperial.ac.uk robin.harrison@synthomer.com eva.harth@vanderbilt.edu n.a.harun@ncl.ac.uk hawker@mrl.ucsb.edu a.s.hayward@durham.ac.uk rchayward@gmail.com sarah.hehir@durham.ac.uk andreas.heise@dcu.ie bahelms@lbl.gov j.p.a.heuts@tue.nl hillmyer@umn.edu Thehien.Ho.Etu@univ-lemans.fr 119 Professor Richard Hoogenboom Dr Ben Hornby Ms Claudia Houben Professor Steve Howdle Dr Jonathan Howse Mr Jinming Hu Dr Lian Hutchings Dr Cecilia Ieong Dr Derek Irvine Professor Frieder Jaekle Mr Chris James Dr Adam Jarvis Mr James Jennings Dr Yan Ji Professor Ming Jiang Dr David Johnson Mrs Elizabeth Jones Ms Fanny Joubert Professor Thomas Junkers Ms Daniela Kalafatovic Ms Yan Kang Mr Christopher Kay Dr Daniel Keddie Ms Elizabeth Kelley Dr Michael Kember Dr Kristian Kempe Dr Ezat Khoshdel Professor Kristi Kiick Dr Solomon Kimani Mr Peter King Dr Ian Kinloch Ms Cathrin Kirchhoefer Mr Aaron Kliene Professor Harm-Anton Klok Professor Bert Klumperman Dr Marzena Kocik Dr Suleyman Koytepe Mr Fanourios Krasanakis Mr Ti-Hsuan Ku Mr Artur Kubilis Ms Isil Kurtulus Ms Emily Kynaston Dr Vincent Ladmiral Dr Muriel Lansalot Dr Nathalie Lavignac Ms Morgane Le Neindre Mr Thomas Lebarbé Professor Sebastien Lecommandoux Mr Frank Leibfarth Dr Ken Lewtas Professor Pei Li Ms Jun Li Mr Guangzhao Li Mr Shicheng Li Ms Ying Li Mr Ang Li Ms Muxiu Li Mr Benjamin Lidster Dr Adam Limer Ms Qiuming Liu Mr Kai Liu Professor Shiyong Liu Mrs Vanessa Locenski Dr Xian Jun Loh Mr Brooke Longbottom Dr Iria Louzao Pernas Dr Donald Loveday Professor Peter Lovell Mr Joseph Lovett Ghent University Infineum UK Ltd University of Warwick University of Nottingham University of Sheffield University of Science & Technology of China Durham University University of Warwick University of Nottingham Rutgers University - Newark Durham University Unilever University of Nottingham Tsinghua University Fudan University Durham University University Of Sheffield Durham university Universiteit Hasselt University of Strathclyde University of Warwick University of Warwick CSIRO Materials Science and Engineering University of Delaware Imperial College London Friedrich-Schiller-Universität Jena Unilever University of Delaware Durham University Durham University University of Manchester University of Warwick University of Kent Ecole Polytechnique Fédérale de Lausanne (EPFL) Stellenbosch University The University of Sheffield Inonu University University of Crete University of California, San Diego Durham University Izmir Institute of Technology University of Bristol University Of Sheffield CNRS - C2P2 Medway School of Pharmacy ESPCI, Laboratoire Matiere Molle et Chimie University Bordeaux 1- LCPO Université de Bordeaux University of California Santa Barbara Infineum Ltd The Hong Kong Polytechnic University Soochow University University of Warwick University of Manchester University of Illinois, Urbana and Champaign ETH Zurich University of Warwick The University of Manchester Unilever Research & Developement Tongji University Tsinghua University University of Science & Technology of China The University of Nottingham University of Cambridge University of Warwick Radboud University Nijmegen CSIRO University of Manchester The University of Sheffield richard.hoogenboom@ugent.be ben.hornby@infineum.com c.houben@warwick.ac.uk steve.howdle@nottingham.ac.uk j.r.howse@sheffield.ac.uk hjm85@mail.ustc.edu.cn l.r.hutchings@durham.ac.uk n.s.ieong@warwick.ac.uk derek.irvine@nottingham.ac.uk fjaekle@rutgers.edu christopher.james@dur.ac.uk adam.jarvis@unilever.com pcxjj2@nottingham.ac.uk jiyan@mail.tsinghua.edu.cn mjiang@fudan.edu.cn d.w.johnson@dur.ac.uk cha07erj@sheffield.ac.uk joubert.fanny@durham.ac.uk thomas.junkers@uhasselt.be daniela.kalafatovic@strath.ac.uk Y.Kang@warwick.ac.uk christopher.kay@warwick.ac.uk daniel.keddie@csiro.au ekelley@udel.edu m.kember07@imperial.ac.uk kristian.kempe@uni-jena.de ezat.khoshdel@unilever.com kiick@udel.edu s.m.kimani@durham.ac.uk p.a.king@durham.ac.uk Ian.Kinloch@manchester.ac.uk C.Kirchhoefer@warwick.ac.uk ak415@kent.ac.uk harm-anton.klok@epfl.ch bklump@sun.ac.za m.kocik@sheffield.ac.uk suleyman.koytepe@inonu.edu.tr fanisk@iesl.forth.gr tiku@ucsd.edu artur.kubilis@durham.ac.uk isilkurtulus@iyte.edu.tr Emily.Kynaston@bristol.ac.uk v.ladmiral@sheffield.ac.uk lansalot@lcpp.cpe.fr n.lavignac@kent.ac.uk morgane.le-neindre@espci.fr lebarbe@enscbp.fr lecommandoux@enscbp.fr Frank.Leibfarth@gmail.com Ken.Lewtas@infineum.com bcpeili@polyu.edu.hk 371932245@qq.com guangzhao.li@warwick.ac.uk Shicheng.Li@postgrad.manchester.ac.uk yingli5@illinois.edu ang.li@mat.ethz.ch Muxiu.Li@warwick.ac.uk anna.chan@manchester.ac.uk adam.limer@unilever.com liuqiuming220@163.com liukai1234a@163.com sliu@ustc.edu.cn paxvl@nottingham.ac.uk xjl21@cam.ac.uk B.Longbottom@warwick.ac.uk L.Iria@science.ru.nl donald.loveday@csiro.au pete.lovell@manchester.ac.uk cha08jl@shef.ac.uk 120 Professor Andrew Lowe Ms Annhelen Lu Mr David Lunn Dr Jean-François Lutz Dr Ning Ma Dr Ben MacCreath Dr Kerstin Mader Dr Jeppe Madsen Mr Eugene Magennis Professor Mahesh Mahanthappa Ms Lise Maisonneuve Ms Hiteshri Makwana Mr Edward Malins Professor Eva Malmström Professor Ian Manners Dr Giuseppe Mantovani Dr Geoff Marks Ms Sarah Mastroianni Professor Robert Mathers Dr Matthew Matthew Gibson Professor Krzysztof Matyjaszewski Professor Heather Maynard Ms Judith McCann Ms Kayleigh McEwan Dr Ronan McHale Ms Holly McKenzie Dr Beulah McKenzie Professor Neil McKeown Ms Aarti Mehta Professor Michael Meier Professor Egbert Meijer Ms Joana Mendes Mrs Patrícia Mendonça Mr Cristian Menzel Dr Laetitia Mespouille Ms Anna Meszynska Dr Phillip Milnes Dr Graeme Moad Ms Dafni Moatsou Dr Sophie Monge Dr Vincent MONTEIL Dr Lucas Montero de Espinosa Ms Beth Moore Ms Caroline Moore Mr John Moraes Dr David Moreton Mr Adam Morgan Mr Andrew Morse Dr Jaroslav Mosnacek Mr Julien Muller Dr Chiara Neto Dr To Ngai Dr Thu Nguyen Dr Julien Nicolas Dr Renaud Nicolay Mr Mads Møller Nielsen Dr Ramon Novoa-Carballal Mr Adam Nunns Mr Gabit Nurumbetov Mr Kim Oberg Mr Patrik Olsson Dr Victoria Osborne Dr Christina Ott Mr Ekrem Ozer Dr Julien Parvole Dr Sagrario Pascual Mr Joseph Patterson Ms Anita Peacock Professor Virgil Percec CAMD, Universty of New South Wales UNIVERSITY OF WARWICK University of Bristol Institut Charles Sadron University of Science and Technology Beijing Agilent Sheffield Hallam Universtiy University of Sheffield The University of Nottingham University of Wisconsin–Madison Laboratoire de Chimie des Polymères Organiques LCPO The University of Nottingham University of Warwick KTH Fiber and polymer technology University of Bristol University of Nottingham Lubrizol Limited University of Delaware Penn State University The University of Warwick Carnegie Mellon University of California at Los Angeles University of Manchester The University of Warwick The University of Warwick The University of Warwick Eindhoven Technical University Cardiff University Natonal Physical lab, India Karlsruhe Institute of Technology (KIT) University of Technology Eindhoven University of Coimbra the University of Coimbra University of Manchester University of Mons Institute Charles Cadron Warwick University CSIRO The University of Warwick Université Montpellier 2 C2P2 Laboratory / CNRS, University of Lyon, CPE Lyon Karlsruhe Institute of Technology The University of Warwick The University of Warwick Key Centre for Polymers and Colloids Lubrizol Limited The University of Warwick The University of Sheffield Polymer Institute SAS Université Montpellier 2 The University of Sydney The Chinese University of Hong Kong Ghent University Univ. Paris-Sud ESPCI Technical University of Denmark University of Bayreuth D-95440 Bayreuth University of Bristol University of Warwick KTH Royal Institute of Technology The University of Warwick Revolymer Ltd. CSIRO Materials Science and Engineering Izmir Institute of Technology CPE Lyon - Laboratoire de Chimie Université du Maine The University of Warwick University of Liverpool University of Pennsylvania a.lowe@unsw.edu.au A.lu@warwick.ac.uk david.lunn@bristol.ac.uk jflutz@unistra.fr nma@ustb.edu.cn ben.maccreath@agilent.com k.mader@shu.ac.uk p.madsen@sheffield.ac.uk paxpm2@nottingham.ac.uk mahesh@chem.wisc.edu maisonneuve@enscbp.fr paxhm2@nottingham.ac.uk e.l.malins@warwick.ac.uk mavem@kth.se ian.manners@bristol.ac.uk giuseppe.mantovani@nottingham.ac.uk gpm@lubrizol.com smastro@udel.edu rtm11@psu.edu m.i.gibson@warwick.ac.uk km3b@andrew.cmu.edu maynard@chem.ucla.edu judith.mccann@postgrad.manchester.ac.uk k.a.mcewan@warwick.ac.uk r.mchale@warwick.ac.uk h.mckenzie@warwick.ac.uk B.E.McKenzie@tue.nl mckeownnb@cardiff.ac.uk aks302117@gmail.com m.a.r.meier@kit.edu e.w.meijer@tue.nl jpachecomendes@gmail.com patmend@gmail.com cristian.menzel@postgrad.manchester.ac.uk laetitia.mespouille@umons.ac.be meszynska@unistra.fr p.j.milnes@warwick.ac.uk graeme.moad@csiro.au d.moatsou@warwick.ac.uk sophie.monge-darcos@univ-montp2.fr monteil@lcpp.cpe.fr lucas.espinosa@kit.edu b.moore@warwick.ac.uk c.moore.3@warwick.ac.uk john.moraes@sydney.edu.au david.moreton@lubrizol.com Adam.Morgan@warwick.ac.uk chp09ajm@shef.ac.uk jaroslav.mosnacek@savba.sk julien.muller@etud.univ-montp2.fr chiara.neto@sydney.edu.au tongai@cuhk.edu.hk Thu.Nguyen@ugent.be julien.nicolas@u-psud.fr renaud.nicolay@espci.fr mon@kt.dtu.dk ramon.novoa-carballal@uni-bayreuth.de an5783@bristol.ac.uk g.nurumbetov@warwick.ac.uk kimober@kth.se p.k.a.olsson@warwick.ac.uk vicky.osborne@revolymer.com christina.ott@csiro.au ekremozer@iyte.edu.tr parvole@lcpp.cpe.fr sagrario.pascual@univ-lemans.fr J.P.Patterson@Warwick.ac.uk Anita.Peacock@Liverpool.ac.uk percec@sas.upenn.edu 121 Professor Sebastien Perrier Mr Nikos Petzetakis Ms Robin Pflughaupt Dr Phuoc Dien Pham Dr Trang Phan Dr Marisa Phelan Mr Daniel Phillips Professor Darrin Pochan Professor Jose A. Pomposo Mr Christian Porsch Mr Alexandre Pprevoteau Dr David Price Ms Nikki Pullan Mr Matthew Purcell Professor Jeffrey Pyun Dr Jose Ramos Professor Madeleine Ramstedt Mr Rajan Randev Ms Lyndsay Randolph Mr Liam Ratcliffe Ms Thanchanok Ratvijitvech Mr Jacob Ray Dr Georgina Rayner Mr Martin Redhead Professor Theresa Reineke Dr Shijie Ren Dr Markus Retsch Ms Sarah-Jane Richards Dr Alexandre Richez Mr Maxwell Robb Mr Mathew Robin Mr Joshua Robinson Dr Nuno Rocha Mr Andrew Ross Dr Peter Roth Professor Stuart Rowan Mr Tobias Rudolph Mr Thomas Ruhland Dr Paul Rupar Professor Thomas Russell Dr Aram Saeed Ms Prabhjot Saini Dr Kei Saito Dr Kei Saito Dr Chris Sammon Professor Amitav Sanyal Mrs Luana Sasso Dr Brian Saunders Professor Daniel Savin Dr Greg Saunders Professor Mitsuo Sawamoto Professor Felix Schacher Dr Mike Schellekens Ms Anna Sanchez-Sanchez Dr Oren Scherman Dr Tara Schiller Dr Helmut Schlaad Mr Bernhard V.K.J. Schmidt Professor Ulrich S Schubert Mr Khaled Sebakhy Professor Turgay Seckin Mrs Mona Semsarilar Professor Arménio Serra Mrs Nur Nabilah Shahidan Dr Peter Shaw Dr Andrew Shooter Ms Giovanna Sicilia Mr Fabio Simoes Professor George Simon Key Centre for Polymers & Colloids The University of Warwick The University of Warwick Université Montpellier 2 Aix-Marseille University Henkel University of Warwick University of Delaware University of the Basque Country KTH Royal Institute of Technology ESPCI, Laboratoire Matiere Molle et Chimie Lubrizol Ltd Aston University University of Nottingham University of Arizona University of the Basque Country UPV/EHU Umeå University The University of Warwick University of California, San Diego University Of Sheffield University of Liverpool The University of Southern Mississippi The University of Warwick University of Nottingham University of Minnesota University of Liverpool University of Bayreuth The University of Warwick University of Leeds University of California The University of Warwick Max Planck Institute of Colloids and Interfaces University of Coimbra The University of Warwick CAMD, University of New South Wales Case Western Reserve University Friedrich-Schiller-University Jena The University of Warwick University of Bristol University of Massachusetts The University of Nottingham Imperial College London Monash University Monash University Sheffield Hallam University Bogazici University University of Nottingham University of Manchester The University of Southern Mississippi Agilent Technologies Kyoto University Friedrich-Schiller-University Jena DSM Coating Resins Centro de Física de Materiales (CSIC, UPV/EHU) University of Cambridge Monash University Max Planck Institute of Colloids and Interfaces Karlsruhe Institute of Technology Freidrich-Schiller-University Jena AIBN, The University of Queensland Inonu University University Of Sheffield University of Coimbra University of Manchester Synthomer Lubrizol The University of Nottingham University of Nottingham Monash University sebastien.perrier@sydney.edu.au N.petzetakis@warwick.ac.uk R.L.Pflughaupt@warwick.ac.uk pdpham@univ-montp2.fr trang.phan@univ-amu.fr marisa.phelan@henkel.com daniel.phillips@warwick.ac.uk pochan@udel.edu josetxo.pomposo@ehu.es porsch@kth.se alexandre.prevoteau@espci.fr david.price@lubrizol.com pullann@aston.ac.uk pcxmp@nottingham.ac.uk jpyun@email.arizona.edu jose.ramos@ehu.es madeleine.ramstedt@chem.umu.se rajan.randev@warwick.ac.uk lrandolp@ucsd.edu chp10lpr@sheffield.ac.uk thr@liv.ac.uk Jacob.Ray@usm.edu g.rayner@warwick.ac.uk paxmr@nottingham.ac.uk treineke@umn.edu shijier@liverpool.ac.uk markus.retsch@uni-bayreuth.de S-J.Richards@warwick.ac.uk a.p.m.richez@leeds.ac.uk mrobb@umail.ucsb.edu m.p.robin@warwick.ac.uk joshua.robinson@mpikg.mpg.de nrocha@eq.uc.pt andrew.ross@warwick.ac.uk P.Roth@unsw.edu.au stuart.rowan@case.edu tobias.rudolph@uni-jena.de thomas.ruhland@uni-bayreuth.de paul.rupar@gmail.com tom.p.russell@gmail.com aram.saeed@nottingham.ac.uk ps507@ic.ac.uk kei.saito@monash.edu kei.saito@monash.edu c.sammon@shu.ac.uk amitav.sanyal@boun.edu.tr paxls@nottingham.ac.uk brian.saunders@manchester.ac.uk daniel.savin@usm.edu greg.saunders@agilent.com sawamoto@star.polym.kyoto-u.ac.jp felix.schacher@uni-jena.de mike.schellekens@dsm.com ana_sanchez@ehu.es oas23@cam.ac.uk tara.schiller@monash.edu schlaad@mpikg.mpg.de bernhard.schmidt@kit.edu ulrich.schubert@uni-jena.de k.sebakhy@uq.edu.au turgay.seckin@inonu.edu.tr m.semsarilar@sheffield.ac.uk armenio.serra@gmail.com nur.shahidan@postgrad.manchester.ac.uk peter.shaw@synthomer.com andrew.shooter@lubrizol.com paxgs3@nottingham.ac.uk paxfs2@nottingham.ac.uk george.simon@monash.edu 122 Dr Gregory Simpson Ms Smriti Singh Mr Thomas Skelhon Mrs Emily Skinner Mr Thomas Smallwood Dr Niels M.B. Smeets Mr Michael Smith Dr Tim Smith Mr Arun Sohdi Ms Katherine Sommer Dr Sebastian Spain Professor Joachim Spatz Ms Sansanee Srichan Mr Roland H. Staff Ms Emma Steeds Professor Martina Stenzel Professor Molly Stevens Professor Fraser Stoddart Ms lu su Mr Cheng Sui Professor Brent Sumerlin Mr Christopher Summers Ms Huanli Sun Mr Liang Sun Professor Mustafa Tabakci Dr Min Tang Dr Lei Tao Dr Roberto Teixeira Mr Farabi Temel Professor Gregory Tew Professor Patrick Theato Dr Efrosyni Themistou Dr Wim Thielemans Ms Kate Thompson Dr Paul Thornton Dr Kristofer Thurecht Mr Richard Todd Ms Tugba Toker Dr Paul Topham Professor J. D. Tovar Dr Scott Trenor Dr Vinh Truong Professor Nicolay Tsarevsky Professor Mike Turner Professor Jan van Hest Dr Jan Hein van Steenis Professor Philipp Vana Professor Kelly Velonia Ms Claudia Ventura Dr Andrew Vogt Ms Antje Vollrath Ms Lenny Voorhaar Ms Tanja Voss Mrs Sema Vural Mr Martin Wåhlander Mr Chris Waldron Mr Thomas Waller Ms Sofie Wallyn Dr Nicholas Warren Dr Carl Waterson Professor Marcus Weck Mr Kongchang Wei Dr Jonathan Wever Mr Joseph Wheeler Professor George Whitesides Dr Michael Whittaker Dr George Whittell Mr Tom Wilks Dr Helen Willcock CSIRO DWI an der RWTH e.V The University of Warwick University of Bath Sheffield Hallam University McMaster University Durham University Lubrizol Ltd Aston University University of Reading University of Nottingham Max Planck Inst. for Intelligent Systems Institut charles sadron Max Planck Institute for Polymer Research University of Nottingham University of New South Wales Imperial College London Northwestern University Fudan University The University of Nottingham Southern Methodist University University of Warwick Soochow University Department of Chemistry, University of Warwick Selcuk University Imperial College London Tsinghua University Ghent University Selcuk University University of Massachusetts University of Hamburg University of Sheffield University of Nottingham The University of Sheffield Durham University AIBN, The University of Queensland Warwick University Izmir Institute of Technology Aston University Johns Hopkins University Milliken and Company University of Warwick Southern Methodist University University of Manchester Radboud University Nijmegen Synthomer Deutschland GmbH University of Goettingen - Institute of Physical Chemistry University of Crete Dublin City University Karlsruhe Institute of Technology (KIT) Organische Chemie Friedrich-Schiller-Universität Jena Ghent University BASF SE Inonu University KTH Royal Institute of Technology The University of Warwick University of Surrey Ghent University Department of Chemistry Innospec Inc New York University Fudan University Imperial College London University of Manchester Harvard University CAMD, University of New South Wales University of Bristol University of Warwick University of Warwick jackie.xavier@csiro.au singh@dwi.rwth-aachen.de t.s.skelhon@warwick.ac.uk E.K.Skinner@bath.ac.uk tcsmallw@my.shu.ac.uk nmbsmeets@gmail.com m.j.p.smith@durham.ac.uk timothy.smith@lubrizol.com sohdiaa@aston.ac.uk ws026905@reading.ac.uk sebastian.spain@nottingham.ac.uk spatz@is.mpg.de sansanee.srichan@etu.unistra.fr staff@mpip-mainz.mpg.de pcxes2@nottingham.ac.uk M.Stenzel@unsw.edu.au m.stevens@imperial.ac.uk stoddart@northwestern.edu 09110440006@fudan.edu.cn paxcs1@nottingham.ac.uk bsumerlin@smu.edu c.j.summers@warwick.ac.uk sunhuanli669@163.com Liang.Sun@warwick.ac.uk mtabakci@gmail.com min.tang05@imperial.ac.uk leitao@mail.tsinghua.edu.cn Roberto.Teixeira@Ugent.be farabitemel42@hotmail.com greg.tew@umass.edu theato@chemie.uni-hamburg.de e.themistou@sheffield.ac.uk wim.thielemans@nottingham.ac.uk k.l.thompson@shef.ac.uk paul.d.thornton@gmail.com k.thurecht@uq.edu.au richard.todd@warwick.ac.uk tugbatoker@std.iyte.edu.tr p.d.topham@aston.ac.uk tovar@jhu.edu scott.trenor@milliken.com V.X.Truong@warwick.ac.uk nvt@smu.edu michael.turner@manchester.ac.uk j.vanhest@science.ru.nl heike.wellmann@synthomer.com pvana@uni-goettingen.de velonia@materials.uoc.gr claudia.ventura2@mail.dcu.ie andrew.vogt@kit.edu antje.vollrath@uni-jena.de lenny.voorhaar@ugent.be tanja.voss@basf.com sema.vural@inonu.edu.tr wahla@kth.se c.s.waldron@warwick.ac.uk t.waller@surrey.ac.uk sofie.wallyn@ugent.be n.warren@shef.ac.uk carl.waterson@innospecinc.com mw125@nyu.edu 081044009@fudan.edu.cn j.weaver@imperial.ac.uk Joseph.Wheeler@postgrad.manchester.ac.uk mikey.whittaker@unsw.edu.au g.whittell@bristol.ac.uk t.r.wilks@warwick.ac.uk h.willcock@warwick.ac.uk 123 Mr Markus Willgert Dr Charlotte Williams Mr Mark Williams Ms Rebecca Williams Dr Paul Williams Mr James Wilson Dr Jonathan Henry Wilson Dr Paul Wilson Mr Craig Wood Dr John Woods Professor Karen Wooley Dr Peter Wright Mr Daniel Wright Dr Huaping Xu Mrs Shi Xiujuan Professor Yusuf Yagci Dr Takuya Yamamoto Mr Pengcheng Yang Ms Zhongqiang Yang Ms Gokcen Yasayan Professor Per Zetterlund Professor Xi Zhang Mr Guanhua Zhang Mr Qiang Zhang Dr Weian Zhang Professor Hanying Zhao Dr Yu Zheng Dr Matthias Zorn Mr Nicolas Zydziak KTH Royal Institute of Technology Imperial College London The University of Sheffield University of Warwick Warwick Effect Polymers University of Warwick Merck Chemicals Ltd University of Warwick Crown Paints Henkel Corporation Texas A&M University Infineum University of Warwick Tsinghua University Soochow University Istanbul technical university Tokyo Institute of Technology Department of Chemistry Tsinghua University University of Nottingham The University of New South Wales Tsinghua University School of Engineering, University of Warwick University of Warwick School of Chemistry, University of Leeds Nankai University Network of Excellence for Functional Biomaterials BASF SE KIT - Karlsruhe Insitute for Technology markuswi@kth.se c.k.williams@imperial.ac.uk chp10mw@shef.ac.uk rebecca.j.williams@warwick.ac.uk paul.williams@polytherics.com J.Wilson.3@warwick.ac.uk henry.wilson@merckgroup.com p.wilson.1@warwick.ac.uk craig.wood@crownpaints.co.uk john.woods@us.henkel.com wooley@chem.tamu.edu peter.wright@infineum.com D.B.Wright@warwick.ac.uk xuhuaping@mail.tsinghua.edu.cn shixiujuan23@gmail.com yusuf@itu.edu.tr yamamoto.t.ay@m.titech.ac.jp n.warren@shef.ac.uk zyang@tsinghua.edu.cn paxgy@nottingham.ac.uk p.zetterlund@unsw.edu.au xi@mail.tsinghua.edu.cn g.h.zhang@warwick.ac.uk Qiang.Zhang@warwick.ac.uk wazhang@ustc.edu hyzhao@nankai.edu.cn sakuragiangel@hotmail.com matthias.zorn@basf.com nicolas.zydziak@kit.edu 124

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