Inflammatory Pain
Keratinocytes
Tissue
injury
Keratinocytes
PAF
F
Platelet
Cytokine
release
Keratinocytes
Keratinocytes
Kerati
Fibroblasts
Mast cell
degranulation
TNF_
+
IL-1`
Neutrophil
Macrophage
NGF
NGF
ATP
LIFR
IL-1R
P2X3
IL-6R
ASIC3
A2
Histamine
mGluR1,55
iGluR
Laminae I-II
of the dorsal horn
H1
PLCa
PIP2
P
Cytokine
release
TRPV1
TrkA
P
Central
Sensitization
Endorphin
receptors
Endorphins
Substance P
release
B1/B2
CB1
2-AG
N v1.8
Na
5-HT
D
P
5-HT2A
SSTR2A
5-HT3
PKC
No
Discover more at abcam.com/biochemicals
cice
p
NGF
tor t
er min
a
TRPV1
Nav1.8
ce P
Substance
BDNF
CGRP
l root gan
sa
gl
io
or
GiRK
PGE2
Bradykinin
IP3
Plasma
extravasation
vasodilation
EP
PKA
DAG
M2
Inhibitory
pathways
Adenosine Glutamate
H+
IL-6
LIF
n
IL-1`
Hyperalgesia
Spinal
cord
Retrograde transport
ls
CGRP
BDNF
Substance P
Inflammatory Pain
Ion channel modulators:
• Calcium
• Sodium
• Potassium
• TRP
Enzyme inhibitors and Signaling tools:
• Cytokines
• TNFα
• PIP2, IP3, DAG and PKC
Glutamate receptor agonists and antagonists
Product
D-AP5
NBQX disodium salt
DL-AP5
CNQX disodium salt
(R)-CPP
Biological action
Competitive NMDA glutamate site antagonist
Potent, selective and competitive AMPA/kainate receptor antagonist
Competitive NMDA glutamate site antagonist
Potent, competitive AMPA / kainate receptor antagonist
Highly potent, competitive NMDA antagonist
Purity
>99%
>98%
>99%
>99%
-
Product code
ab120003
ab120046
ab120004
ab120044
ab120159
Biological action
α7 nicotinic acetylcholine receptor agonist
Subtype-selective α7 nAChR antagonist Purity
>98%
>99%
Product code
ab120560
ab120542
Biological action
Serotonin-norepinephrine reuptake inhibitor
Standard selective 5-HT1a receptor agonist; affinity for 5-HT7 receptors
Highly potent, selective 5-HT2B antagonist
Selective 5-HT3 antagonist
Endogenous neurotransmitter, 5-HT receptor agonist
Potent, selective, silent 5-HT1A receptor antagonist
Fluorescent 5-HT1B antagonist
Purity
>99%
>99%
>99%
>98%
>99%
>98%
>97%
Product code
ab120715
ab120582
ab120546
ab120134
ab120528
ab120550
ab118650
Biological action
Potent, selective CB1 agonist
Endogenous cannabinoid in water soluble emulsion
Purity
>98%
>98%
Product code
ab120096
ab120429
Biological action
Bradykinin receptor agonist
Selective competitive antagonist of CGRP receptors
Sensory neuropeptide
Purity
>98%
>95%
>95%
Product code
ab120470
ab142492
ab120170
Nicotinic receptor agonists and antagonists
Product
GTS-21 dihydrochloride (DMBX-A)
α-Bungarotoxin
Serotonin agonists and antagonists
Product
Venlafaxine hydrochloride
8-Hydroxy-DPAT hydrobromide
LY 272015 hydrochloride
Ondansetron
Serotonin hydrochloride (5-HT)
WAY-100635 maleate
ZM549865 Fluorescent ligand (Red)
Cannabinoid agonists and antagonists
Product
ACEA (ethanol solution)
Anandamide (in water soluble emulsion)
Neuropeptides
Product
Bradykinin α-Calcitonin Gene Related Peptide (8-37)
Substance P Discover more at abcam.com/biochemicals
Potent, selective
and reversible,
use-dependent inhibitor of
voltage-dependent sodium
channels. TTX citrate is
water soluble.
Purity: >98%
Novel light-sensitive RuBi
caged ligands
• Activated by visible
wavelengths of light
• No harmful UV light of
expensive quartz optics
• Fast uncaging speeds –
single photochemical step
High quality, exceptional
value range
• Receptor agonists
and antagonists
• Ion channel modulators
• Enzyme inhibitors
• Cell signaling
pathway tools
Excellent supporting data now available for
many products
Copyright © 2013 Abcam, All Rights Reserved.
269b_13_TJ
Receptor agonist and antagonists:
• Adenosine & Purinergics
• Chemokines
• Glutamate
• Histamine
t
u c ts
od h
Pr hlig
g
hi
Increase synaptic
transmission with
Tetrodotoxin citrate
Study inflammatory pain pathways with our exceptional quality range including: