THE SCRIPPS RESEARCH INSTITUTE
I0666 NORTH TORREY PINES ROAD
LA JOLLA, CALIFORNIA 920]7
6t9 455-9tOO
FOR IMMEDIATE
#080792-02
RELEASE
For Information:
Sue Pondrom
(619) 554-8290 office
(619) 4s0-0s20 home
NTII AWARDS $1 ffiLLION
LA JOLLA, cALrF Aug.
Blood
Institute
$1 nirrion
to
Institute
blood
of
to
cells
the
factor,
Arthough
future
grant,
research
irnplications
shock
syndrome,
blood
damage.
stroke
intervene
focuses
totals
at
has awarded
Research
in
circulating
to
the
in
blood
basic-science
focus
on
coagulation.
revel,
the
and treatment
of
septic
tissue
factor
is
expressed
in
event
attack.
individual,
limit
wilr
91,o7B ,4s7,
prevention
for
and heart
rocalized
rrour research
in
Lung and
bleeding
expression
the
prevents
of
vessel
inappropriate
rr Mackman says.
coagulation,
factor
Health
The scripps
gene involved
still
healthy
vessers
This
of
of
Heart,
gene regulation
which
is
are
rrrn a nornal,
around
fnstitutes
factor
a cell-surface
the
The National
monocytes.
The five-year
tissue
National
tissue
called
L992 --
7,
Mackman, ph.D.
Niger
study
TO SCRIPPS RESEARCHER
disease
in
goal
is
situationsr
the
disease
understand
So that
process,
on two main diseases
arteriosclerosis
to
the
eventually
rr he notes.
septic
.
ITTORE
role
of
we'Il
tissue
be able
Mackmants research
shock and
to
PAGE 2
septic
shock
responsible
This
for
syndrome
disorders
factor
80,000
is
including
fibrin
Mackman says
tissue
factor
against
research,
the
diseases
rrWe believe
factor
that
are probably
expressed
coagulation
attacks
strokerrf
rrrn our
moder to
in
a rnajor
Tissue
mediator
of
blood
failure.
inhibiting
protected
antibody
shock.
in
rn his
pathways
regulatory
septic
a number of
attacks
that
shock.
blood
vessel
and stroke.
complications
associated
circulating
fat-laden
w€'re
blood
monocytes
occlude, the
using
regulation
Mackman says.
of
the
within
artery,
tissue
with
contacting
the
Ieading
monocyte
may allow
the
level
gene expression.
us to
factor
gene expression
rrUnd.erstanding
the
of
infection.
Mackman is
due to
could
clinical
plaque.
to
heart
Mackman explains.
research,
understand
monocyterrr
interests
heart
of
septic
factor
thrombotic
Subsequent
or
tissue
includes
in
the
is
states.
inappropriate
a monoclonar
that
which
culminating
atherosclerosis
of
is
that
united
have shown that
investigate
disease
arterioscrerosis,
to
a baboon model of
in
expression
The other
tissue
with
the
and viral
and organ
studies
Maekman will
control
leads
disease
variety
vasculature
deposition
activity
in
a wide
sepsis
which
recent
letharity
with
the
shock
multisystem
annually
bacterial
within
bacteremic
coagulation,
deaths
associated
expression
fatal
a comprex,
is
intervene
rl
UORE
in
the
the
in
molecular
disease
gene as a
the
events
in
process
at
-l
PAGE 3
Born in Rustington,
in genetics
at the university
arso was a postdoctoral
Scripps
England, Mackman received
of Leicester,
ferrow
Research Institute
1989 became an assistant
Last winter,
for
was given
his
two years.
doctorate
where he
He came to The
fellow
and in
member of the Departrnent of Immunology.
Mackman was named the first
research
prize
winner
of the
Louis N. Katz Basic Science Research
Young Investigators.
for
England,
in 1987 as a research
American Heart Associationts
Prize
for
his
The prestigious
on tissue
###
factor
national
award