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I4AY 18
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SINGLE TREJAT}TENTWITE EXPERITTENAAIJDRUG
GEITERATES SIGNIFICANT EAIRY CEIJIJ IJEUKEIIIA REI'IISSIODIS
SAN DIEGO, CALIF.
developed
and tested
La Jolla,
Calif.
--
remissions
Scripps
at
with
a single
rare
but
and bone marrovr, hairy
cell
with
As the
drug
some 500 to
pri-ncipar
at
11 a.m.
society
of
clinicar
presentation
noted
intravenous
obtained
three
Foundation
a high
number of
of
in
complete
treatment
in
Lawrence piro,
that
infusion
(two percent)
except
fatal
leukemia
M.D.,
hairy
cerl
director
of
investigator
today
at
the
in
2-CdA.
response,
not
two are
seen in
clj-nical
piro
annual
of
about
the
blood
6'000
neeting
of
carif.
CeII
received
a single
L4g,
MORE
the
trial
American
of
Following
2-
seven-day
L26 (85 percent)
Following
today.
the
the
Leukemia. rt
18 (L2 percent)
respond.
of
The title
Cornplete Remissions
Of the
alive
trials
presented
san Diego,
in Hairy
t-48 patients
did
is
for
(2-cdA),
(2-CdA)
of
rnalignancy
600 new cases each year.
was rrProlonged
a complete
L48 patients
and Research
usually
oncology
Chlorodeoxyadenosine
Piro
Clinic
to
2-ihlorodeoxyadenosine
results
his
drug
Green Cancer Center.
A relatively
Arnericans
A nehr cancer
course
according
Clinic's
Lggz --
Scripps
has generated
patients,
reukemia
May 18,
a partiar
treatment,
response,
all
PAGE 2 --
2-CdA
Fever
drug.
FOR IIAIRY
was the
only
Wtrereas other
nausea,
vomiting,
abnormal
liver
seen with
significant
forms
hair
of
loss,
or kidney
side
and his
two years
ago in
early
chenotherapy
function,
skin
with
significant
rash
no significant
the
or
reactions
were
in
first
New Enqland
with
reported
Journal
of
population
a much larger
with
Medicine.
z-CdA
since
ttwerve been able
t2 patients,
only
success
the
efficacy
of
to
2-CdA for
ceJ.l leukemia, rr he said.
hairy
Additional
Center
in
rnedical
Houston,
centers,
Texas;
and Northwestern
York;
including
Long Island
University
in
tested
z-CdA rrand have confirmed
our
highly
effective
Piro
and durable
M.D.
Jewish
Anderson
Hospital
Chicago,
Illinois
observations
treatment
for
in
New
have
that
hairy
cancer
cell
this
is
a
leukemia,
rr
added.
The National
investigate
ttthis
that
called
cancer
additionat
drug
Institute
is
apprications
represents
nucleosides,
which
one type
also
sponsoring
piro
of
2-cdA,
of
a new group
have had significant
trials
said,
of
impact
to
noting
drugs
in
cancer
rl
treatment.
Aruong the
46-year-o1d
Scripps
Clinic,s
rrthanks
to
the
noted
can cause
conjunctivitis,
colleagues
the
trials
demonstrate
is
effect
z-CdA.
Piro
those
CEIJL LEUKEMIA
patients
Cheryt
Nichols
more recent
2-cdA,
University
whorve
of
r've
just
Southern
responded
to
of Mission
treatment
graduated
California.rl
I{ORE
the
2-CdA treatment
Viejo,
Catif.
recipients,
from
the
One of
she says
masters
progran
at
PAGE 3 --
*
2CAA FOR HAIRY
Last
fall,
Nichols
rrbut r was married,
work
job,
what
noticed
a mother,
and trying
was tiredr,t
CELL LEUKE}TIA
to
synptoms
fatigug
and headache,
down a part-time
holding
finish
of
my rnasterrs
degree.
social
No wonder
r
she said.
convi-nced
concentrate
on her
her
to
see a doctor
studies.
rt
got
was her
so bad that
inabirity
to
she had to
drop
and suggested
she
classes.
Her doctor
be treated
returned
at
to
social
work
cancer
social
diagnosed
scripps
schoor
hairy
cell
crinic.
After
and graduated
degree.
work to
Nichols
said
utilize
her
this
###
leukemia
treatment
month
she hopes
with
to
experiences.
in
December,
a master
find
she
of
emplolment
in