Product datasheet
Anti-LPHN1 antibody - N-terminal ab140825
1 Image
Overview
Product name
Anti-LPHN1 antibody - N-terminal
Description
Rabbit polyclonal to LPHN1 - N-terminal
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applications
IHC-P
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Hamster, Cow, Pig, Monkey, Gorilla, Opossum
Immunogen
Synthetic peptide, containing 16 amino acids, from the N-terminal extracellular region of Human
LPHN1.
Positive control
Human brain (neurons and glia) tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C.
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab140825 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
IHC-P
Abreviews
Notes
Use a concentration of 8 µg/ml. Perform heat mediated antigen retrieval before
commencing with IHC staining protocol.
Target
1
Function
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin
present in black widow spider venom which triggers massive exocytosis from neurons and
neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact
and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis.
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.
Domain
The extracellular domain coupled to the a single transmembrane region are sufficient for full
responsiveness to alpha-latrotoxin.
Post-translational
modifications
Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane
subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the
endoplasmic reticulum or in the early compartment of the Golgi apparatus.
Cellular localization
Cell membrane. Cell projection > axon. Cell projection > growth cone. Cell junction > synapse.
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > synaptosome.
Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals
near synaptic clefts.
Anti-LPHN1 antibody - N-terminal images
Immunohistochemical analysis of formalinfixed, paraffin-embedded Human brain
(neurons and glia) tissue labelling LPHN1 with
ab140825 at 8 ug/ml.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - Anti-LPHN1
antibody - N-terminal (ab140825)
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Terms and conditions
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