John Tyrell
Department of Chemistry & Biochemistry
University of North Carolina Wilmington
910-962-7299
tyrellj@uncw.edu
Education
1/75 - 1/78
Ph.D. Organic Chemistry University of Massachusetts
"Intramolecular Reactions of Reissert Compounds" Research
involving new synthetic routes to heterocycles.
9/70 - 5/74
B.S. Chemistry
Boston College
"Scholar of the College" Award
2002
Self-taught in patent law. Passed the bar exam of the U.S. Patent
Office.
Teaching Experience
8/00 – Present
University of North Carolina Wilmington
With others, began Corporate MS Chemistry program; developed
into online program; graduate coordinator for 50 distance graduate
students.
Courses Taught:
CHM 485, 585
CHM 101
MGT 350
CHM 211
CHM 211L
CHM 212
CHM 516
CHM 586
Industrial and Polymer Chemistry
General Chemistry
Principles of Management
Organic Chemistry
Organic Chemistry Laboratory
Organic Chemistry
Advanced Organic Chemistry
Fundamentals of Heterocycles with an Emphasis on Pharmaceuticals
John Tyrell
9/94-12/96
Erie County Community College
Taught one evening lecture course each semester and also the
accompanying laboratory courses. Courses taught include
“Organic Chemistry”, “Introductory Chemistry”, and “General,
Organic and Biochemistry”, a one semester course for nursing and
health care students.
Miscellaneous
While in industry worked with many graduate and undergraduate
students - internships; co-ops; summer jobs
Laboratory instructor as a senior and each year as a graduate
student
Industrial Experience
9/90 – 7/00
OxyChem Technology Center; Grand Island, NY
Leadership positions that involved the conception, development and commercialization
of technologies new to OxyChem.
3/98 – 7/00
Promoted to Technical Director. Led a group of 37 scientists (16
Ph.D.s) dedicated to developing new chemistries and processes.
Support business objectives in chemical intermediates for
pharmaceutical and agricultural applications. Responsible for all
technical aspects from idea through successful plant scale up. Key
interface with manufacturing and business areas.
10/96 - 3/98
Report to the Senior Vice-President of Technology. Responsible
for the identification for new business areas and entry strategy.
This included the identification and justification of acquisition
targets. This grew from an individual effort to leading a group of
people assembled from marketing, business development and
commercial information. Focus on sulfur compounds and polymer
additives.
9/93 - 9/96
Proposed new research areas that impacted OxyChem core
businesses of polyethylene and polyvinylchloride. After concept
development, gained support from business areas that previously
had not worked with the Technology Center and led joint efforts in
these programs. Led research effort in metallocene catalysis that
was hailed by trade journals (Catalyst Monitor; Plastics World) as
changing paradigms about single site catalysis.
John Tyrell
9/90 - 8/93
Technical Manager for OxySIM, a specialty polyimidesiloxane
for microelectronic applications. Responsible for all technical
aspects of program as we went from a laboratory curiosity to what
is now a joint venture with annual sales in excess of $10 million.
Responsibilities included invention, application research, technical
service, technical marketing to include design and preparation of
brochures and trade show booths. Presentations at 1991
International Electronic Manufacturing Technology Symposium in
Tokyo. Received Management Award for success of the project.
10/79-9/90
GE Plastics; Mt. Vernon, IN and Pittsfield, MA
Eleven years of technical and managerial experience, using
technical innovation and teamwork to enable manufacture of
identified products and the invention of new products to fulfill
market needs. Continuous progression of responsibilities in the
areas of polycarbonate, polyester and copolymer research.
Conception, laboratory development, piloting and manufacturing
scale-up of novel polyetheresters which are the basis of the
Lomod product line. Responsible for all polymer and blend
modifications, as well as the interface for marketing,
manufacturing and the EPA.
Invention and implementation of stabilization system that enabled
U.S. production of GE's largest volume product.
Manager of analytical department during start-up of new eighty
million dollar plant. Responsible for R&D / Manufacturing
support, competitive analyses, QC methods and technician
training, and troubleshooting startup problems.
Fourth person to attain the status of Senior Scientist (highest
technical level in GE Plastics).
Jaquiss Award recipient - $7,500 management award for the
technologist with the biggest impact on GE marketing.
2/78-9/79
American Cyanamid; Bound Brook, NJ
Laboratory development and plant scale-up of new syntheses of
pharmaceuticals and fine chemicals.
John Tyrell
Publications and Presentations
Fundamentals of Industrial Chemistry, Wiley, 2014, John Tyrell
Orthorhombic Polymorphs of 1-Phenyl-3-(3-Hydroxyphenyl)-2Propen-1-One, Geremia Jennings, Mark D. Smith. Shan-Ming Kuang,
L. Mark Hodges, John Tyrell, R. Thomas Williamson, and Pamela Seaton, J
Chem Crystallogr., 2012, Volume 42, Number 2, Pages 159-164
Fundamentals of Heterocyclic Chemistry, Wiley, 2010, Louis Quin and John
Tyrell
“Diclofenac Salts”, presentation at the 2008 American Association of
Pharmaceutical Scientists (AAPS) Annual Meeting November 2008, and
Exposition in Atlanta by John Burke, Elsie Melsopp, G. Brooks Avery Jr., and
John Tyrell.
“E-Learning Chemistry”, March 2007 233rd ACS National Meeting, James H.
Reeves and John Tyrell
The Removal of Cremephor® EL from Paclitaxel for Quantitative Analysis by
HPLC-UV J of Pharmaceutical and Biomedical Analysis 41 (2006) 117-123 by
James D. Perdue, Pamela J. Seaton, John A. Tyrell and Daniel R. DeVido
“Development of a Complementary Chemiluminescence / HPLC Method for
Predicting the Chemical Fate of 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4dione.” poster presented at the 54th Southeast Regional Meeting of the American
Chemical Society in Charleston, SC (2002) by Jennifer M. Jones, Stephen A.
Skrabal and John Tyrell.
“A Study of the Regioselectivity of Zeolite-Assisted Nitration of Toluene.” poster
presented at the 54th Southeast Regional Meeting of the American Chemical
Society in Charleston, SC (2002) by Joel M. Barden III and John Tyrell.
“Comparison of Various Chiral Stationary Phases for the Chromatographic
Separation of Chiral Pharmaceuticals” poster presented at the 7th UNCW
Symposium on Chemistry and Biochemistry (2004) by Sherry E. Layton, Dean
Shirazi, John Tyrell, and Ned Martin
“Analytical Method Development of a Multi-active Pharmaceutical Formulation
using a Scientific Approach.” poster presented at the 7th UNCW Symposium on
Chemistry and Biochemistry (2004) by Katherin Schlipp, Dean Shirazi, John
Tyrell, and Ned Martin
John Tyrell
“Analytical Method Development of a Multi-Active Separation using a
Mathematical Approach” poster presented at the November 9, 2004 AAPS in
Baltimore by Katherin Schlipp, Dean Shirazi, Tania Toney-Parker, John Tyrell,
and Ned Martin
Choi, J.O.; Rosenfeld, J.C.; Tyrell, J.A.; Yang, J.H.; Jeng, S.; Xu, M.; Kwok, H.S.
“Photosensitive Polyimidesiloxanes” Proceedings of the Ninth International
Technical Conference on Photopolymers 1991.
Choi, J.O.; Rosenfeld, J.C.; Tyrell, J.A.; Yang, J.H.; Rojstaczer, S.R.; Takeda, T.
“Novel Photosensitive Polyimidesiloxanes” Proceedings of the 1991 Japan
International Electronic Manufacturing Technology Symposium.
Rojstaczer, S.R.; Tyrell, J.A.; Takeda, T. “New Advances in Polyimidesiloxanes
for Microelectronic Applications” Proceedings of the 1991 Japan International
Electronic Manufacturing Technology Symposium.
Jeng, S.; Kwok, H.S.; Tyrell, J.A. “Reactive Ion Etching of Polyimidesiloxanes in
Fluorine-Containing Discharges” J. Vac. Sci. Technol., A (1992), 10(4, Pt. 1),
1124-7. Rojstaczer, S. R.; Tyrell, J.A.; Tang, D.Y. “Recent Advances in
Polyimidesiloxanes for Microelectronics Applications” Fifth International SAMPE
Electronic Materials and Processes Conference (1991), 310-14.
Jeng, S.; Xu, M.; Kwok, H.S.; Tyrell, J.A. “Photoablation of Polyimidesiloxanes
under Deep UV Irradiation.” Fifth International SAMPE Electronic Materials
and Processes Conference (1991), 342-6.
Choi, J.O.; Rosenfeld, J.C.; Tyrell, J.A.; Yang, J.H.; Rojstaczer, S.R.; Jeng, S.
“Photosensitive Polyimidesiloxanes” Polym. Eng. Sci. (1992), 32(21), 1630-3.
Tyrell, J.A. “Intramolecular Reactions of Reissert Compounds” Univ.
Massachusetts, Amherst, Mass., USA. Avail. Univ. Microfilms Int., Order No.
7820386. (1978) From: Diss. Abstr. Int. B 1978, 39(5), 2318-19.
Tyrell, J.A.; McEwen, W.E. “Intramolecular Reactions of Reissert Compounds” J.
Org. Chem. (1981), 46(12), 2476-9
68 Issued U.S. patents
S. M. Cooper, S. J. Shafer, and J. A. Tyrell, "Polycarbonates Stabilized with
Sulfolane Derivatives", U.S. Pat. No. 4,362,829 (1982)
N. R. Rosenquist and J. A. Tyrell, "Flame Retardant Polycarbonates", U.S. Pat.
No. 4,371,650 (1983)
John Tyrell
J. A. Tyrell and G. Freimiller, " Carbonate Copolymers Prepared from Imide
Reactants",
U.S. Pat. No. 4,393,190 (1983)
V. Mark and J. A. Tyrell, "Stabilized Polycarbonate Compositions", U.S. Pat. No.
4,403,054(1983)
S. M. Cooper, S. J. Shafer, and J. A. Tyrell, "Stabilized Polycarbonate
Compositions",
U.S. Pat. No. 4,407, 996 (1983)
J. A. Tyrell, P.Y. Liu, and G. Freimiller, "Composition Comprising a Polyolefin and
a Block Copolymer of a Dihydric Phenol Monomer, a Carbonate Precusor and a
Polyphenylene Oxide Resin", U.S. Pat. No. 4,463,132 (1984)
J. A. Tyrell, O. M. Boutni, and G. Freimiller, "Composition Comprising Graft
Polycarbonates", U.S. Pat. No. 4,469,852 (1984)
N. R. Rosenquist and J. A. Tyrell, "Compatibilization of Polycarbonate Blends",
U.S. Pat. No. 4,496,693 (1985)
D. B. G. Jaquiss, R. J. McCready, and J. A. Tyrell, "Stabilized PolycarbonatePolyester Compositions" U.S. Pat. No. 4,532,290 (1985)
N. R. Rosenquist and J. A. Tyrell, "Flame Retardant Polycarbonate", U.S. Pat.
No. 4,535,108 (1985)
N. R. Rosenquist and J. A. Tyrell, "Compatibilization of Polycarbonate Blends",
U.S. Pat. No. 4,552,924 (1985)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Ester
Elastomers", U.S. Pat. No. 4,556,688 (1985)
J. A. Tyrell, "Stabilized (Poly)Ester/(Poly)Carbonate Blend", U.S. Pat. No.
4,560,722 (1985)
J. A. Tyrell and V. Mark, "Copolyetheresters from Caprolactone", U.S. Pat. No.
4,569,973 (1986)
J. A. Tyrell and G. Freimiller, "Hydrolytically Stabilized Polycarbonate", U.S. Pat.
No. 4,576,982 (1986)
J. A. Tyrell and G. Freimiller, "Aromatic Polycarbonate Containing Thieno-2-one5,5 dioxide Terminal Groups", U.S. Pat. No. 4,595,733 (1986)
John Tyrell
J. A. Tyrell and G. Freimiller, "Polycarbonate End-Capped with Vinylene
Carbonate Compound", U.S. Pat. No. 4,661,567 (1986)
R. J. McCready and J. A. Tyrell, " Polyetherimide Esters", U.S. Pat. No.
4,711,933 (1988)
R. J. McCready and J. A. Tyrell, " Translucent Polyetherimide Ester
Compositions", U.S. Pat. No. 4,711,947 (1988)
R. J. McCready and J. A. Tyrell, " Polyetherimide Esters Exhibiting Improved
Tensile Elongation", U.S. Pat. No. 4,711,948 (1988)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Ester Elastomers
Exhibiting Improved Hydrolytic Stability", U.S. Pat. No. 4,714,753 (1988)
R. J. McCready and J. A. Tyrell, “Polyetherimide Esters", U.S. Pat. No. 4,714,754
(1988)
R. J. McCready and J. A. Tyrell, “Thermoplastic Polyetherimide Ester Elastomers
Exhibiting Improved Thermal Properties", U.S. Pat. No. 4,714,755 (1988)
R. J. McCready and J. A. Tyrell, "Block Polyetherimide Ester Polymers", U.S.
Pat. No. 4,732,947 (1988)
R. J. McCready and J. A. Tyrell, "Solid Phase Polycondensation Process for the
Production of High Molecular Weight Polyetherimide Ester Polymers", U.S. Pat.
No. 4,732,948 (1988)
R. J. McCready and J. A. Tyrell, "Crosslinked Polyetherimide Ester Polymers",
U.S. Pat. No. 4,740,563 (1988)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Esters", U.S. Pat.
No. 4,740,564 (1988)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Ester Polymers
having Hydroxy - Terminated Polylactone Component", U.S. Pat. No. 4,740,565
(1988)
J. A. Tyrell, R.J. Axelrod, and D.B.G. Jaquiss, "Flame Retardant Compounds and
Thermoplastic Compositions Containing the Same", U.S. Pat. No. 4,743,637
(1988)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Ester Polymers
Exhibiting High Flexural Modulus ", U.S. Pat. No. 4,760,112(1988)
John Tyrell
J. A. Tyrell and O.M. Boutni, "Thermoplastic Molding Compositions Exhibiting
Improved Melt Flow Properties", U.S. Pat. No. 4,778,855(1988)
R. J. McCready and J. A. Tyrell, "Thermoplastic Polyetherimide Ester Polymers
Exhibiting Improved Flexibility ", U.S. Pat. No. 4,795,790(1989)
J. A. Tyrell, N. Liu and R. J. McCready, "Flame Retardant Polyetherimide Ester
Elastomers", U.S. Pat. No. 4,798,858(1989)
R. J. McCready and J. A. Tyrell, "Polyetherimide Amide from Polyoxyalkylene
Diimide Dicarboxylic Acid", U.S. Pat. No. 4,861,862(1989)
J. A. Tyrell and L.R. Wallace, "Polyesters with Agents for Reducing Melt
Viscosity", U.S. Pat. No. 4,882,375(1989)
R. J. McCready and J. A. Tyrell, "Polyoxyalkylene Polyimide Polymers", U.S.
Pat. No. 4,929,716(1990)
J. A. Tyrell, R.J. Axelrod, and D.B.G. Jaquiss, "Flame Retardant Compounds and
Thermoplastic Compositions Containing the Same", U.S. Pat. No.
4,959,481(1990)
J. A. Tyrell, M.R. McCormick, T.A. Morelli, W.J. Peascoe, S.F. Rasch, and M.T.
Wong, "Copolyetherester Elastomeric Blends", U.S. Pat. No. 4,992,506(1991)
J. A. Tyrell, P.D. Sybert, C.Y. Han, S.B. Brown, D.J. McFay, W.L. Gately and
R.A. Florence, "Polyphenylene ether-polyester Copolymers, Precursors therefor,
Compositions Containing Said Copolymers, and Methods for Their Preparation",
U.S. Pat. No. 5,015,698(1991)
J. A. Tyrell and J. Willey, "Polyester Compositions Exhibiting Enhanced Melt
Viscosity", U.S. Pat. No. 5,026,790(1991)
J. A. Tyrell, T.A. Morelli, W.J. Peascoe, and S.F. Rasch, "Copolyetherester
Elastomeric Compositions", U.S. Pat. No. 5,112,915(1991)
J. A. Tyrell, J. Rosenfeld, J. Choi, and D.Y. Tang, "Diamines and Photosensitive
Polyimides made Therefrom", U.S. Pat. No. 5,177,181(1993)
J. A. Tyrell and J. Choi, "Photocrosslinkable Polyimide Ammonium Salts", U.S.
Pat. No. 5,241,041(1993)
J. A. Tyrell and J. Willey, "Copolyetherimide Ester Compositions", U.S. Pat. No.
5,254,640(1993)
John Tyrell
J. A. Tyrell and J. Willey, "Blow-moldable Copolyetherimide Ester Compositions
with Salts of Aliphatic Polycarboxylic Acids", U.S. Pat. No. 5,262,493(1993)
J. A. Tyrell, S.R. Rojstaczer, and D.Y. Tang, "Polyimidesiloxane Solution and
Method of Coating Substrates", U.S. Pat. No. 5,317,049(1994)
J. A. Tyrell and W.J. Peascoe, "Polyetherimide Ester Elastomeric Compositions",
U.S. Pat. No. 5,338,797(1994)
J. A. Tyrell and G.F. Smith, "Amine-Functionalized Polyester", U.S. Pat. No.
5,384,387(1995)
J. A. Tyrell and G.F. Smith, "Amine-Functionalized Polyester", U.S. Pat. No.
5,519,107(1996)
J. A. Tyrell, J. Choi, and P. Dubell, "Forming Polyimide Coatings by Screen
Printing", U.S. Pat. No. 5,554,684(1996)
J. A. Tyrell, ; S. Nagy, R. Krishnamurti, L.Cribbs, and M. Cocoman,
“Polymerization of Alpha-olefins with Transition Metal Catalysts based on
Bidentate Ligands containing Pyridine or Quinoline Moiety”, U.S. Pat. No.
5,637,660 (1997)
J. A. Tyrell, and S. Nagy, “Supported Catalyst”, U.S. Pat. No. 5,744,417(1998)
J. A. Tyrell, and S. Nagy, “Polysiloxane Supported Metallocene Catalysts”, U.S.
Pat. No. 5,747,404(1998)
J. A. Tyrell, S.Nagy, R. Krishnamurti and B.P. Etherton, “Alpha-Olefin
Polymerization Catalysts”, U.S. Pat. No. 5,756,611(1998)
J. A. Tyrell, S. Nagy, R. Krishnamurti, and B.P. Etherton, “Olefin Polymerization
Catalysts containing Benzothiazole”, U.S. Pat. No. 5,914,408(1999)
J. A. Tyrell, S. Nagy, and B.P. Etherton, “Sulfonyl Catalysts and method of Using
the Same”, U.S. Pat. No. 6,008,394 (1999)
J. A. Tyrell, S. Nagy and Leonard V.Cribbs , "Catalyst System Containing
Reaction Product of Liquid Silicone and Polyamine", U.S. Pat. No. 6,077,806
(2000)
J. A. Tyrell, ; S. Nagy, R. Krishnamurti, and B.P. Etherton, “Polymerization-Stable
Anionic Ancillary Ligand Containing Alkylimido Catalysts and Method of using the
Same”, U.S. Pat. No. 6,114,270 (2000)
J. A. Tyrell, S. Nagy and Leonard V.Cribbs, " Modified Polysiloxane Catalysts
and a Method of using the Same ", U.S. Pat. No. 6,121,183 (2000)
John Tyrell
J. A. Tyrell, S. Nagy, R. Krishnamurti, and B.P. Etherton "Olefin Polymerization
Catalysts Containing Amine Derivatives", U.S. Pat. No. 6,204,216 (2001)
J. A. Tyrell, and S. Nagy, "Method of Polymerizing Vinyl Chloride Monomer using
an Organocobalt (III) Catalyst", U.S. Pat. No. 6,218,486 (2001)
J. A. Tyrell, S.R. Rojstaczer, and J.C. Rosenfeld, "Polyimidesiloxane Adhesive",
U.S. Pat. No. 6,218,496(2001)
J. A. Tyrell, S. Nagy, R. Krishnamurti, and B.P. Etherton "Single-site Catalysts for
Olefin Polymerization", U.S. Pat. No. 6,232,260 (2001)
J. A. Tyrell, S. Nagy, R. Krishnamurti, and B.P. Etherton "Olefin polymerization
catalysts containing amine derivatives ", U.S. Pat. No. 6,281,308 (2001)
J. A. Tyrell, S. Nagy, B.P. Etherton and R. Krishnamurti "Single-Site Catalysts
for Olefin Polymerization", U.S. Pat. No. 6,376,629 (2002)
J.A. Tyrell and S. Nagy “Method of Polymerizing Vinyl Chloride Monomer”, U.S.
Pat. No. 6,462,153 (2002)
J. A. Tyrell, S. Nagy, B.P. Etherton, L.V. Cribbs, M. Cocoman and R.
Krishnamurti “ Transition Metal Catalysts Containing Bidentate Ligands and
Method of Using and Preparing Same”, U.S. Pat. No. 6,759,493 (2004)
J. A. Tyrell, S. Nagy, B.P. Etherton, L.V. Cribbs, M. Cocoman and R.
Krishnamurti “ Transition Metal Catalysts Containing Bidentate Ligands and
Method of Using and Preparing Same”, U.S. Pat. No. 6,790,918 (2004)
John Tyrell